Relevant bibliographies by topics / Iron overload

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Iron overload'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Iron overload"

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Zhabyeyev, Pavel, Subhash K. Das, Ratnadeep Basu, et al. "TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease." American Journal of Physiology-Heart and Circulatory Physiology 314, no. 5 (2018): H978—H990. http://dx.doi.org/10.1152/ajpheart.00597.2017.

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Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3−/−) and wild-type (WT) mice to 12 wk of chronic iron overload. Whereas WT mice with iron overload developed diastolic dysfunction, iron-overloaded Timp3−/− mice showed worsened cardiac dysfunction coupled with systolic dysfunction. In the heart, loss of Timp3 w
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Marfil-Rivera, L. J. "Iron overload." Medicina Universitaria 17, no. 69 (2015): 240–42. http://dx.doi.org/10.1016/j.rmu.2015.08.001.

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Siah, Chiang W., Debbie Trinder, and John K. Olynyk. "Iron overload." Clinica Chimica Acta 358, no. 1-2 (2005): 24–36. http://dx.doi.org/10.1016/j.cccn.2005.02.022.

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Hulihan, Mary M., Cindy A. Sayers, Scott D. Grosse, Cheryl Garrison, and Althea M. Grant. "Iron Overload." American Journal of Preventive Medicine 41, no. 6 (2011): S422—S427. http://dx.doi.org/10.1016/j.amepre.2011.09.020.

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Tsay, Jaime, Zheiwei Yang, F. Patrick Ross, et al. "Bone loss caused by iron overload in a murine model: importance of oxidative stress." Blood 116, no. 14 (2010): 2582–89. http://dx.doi.org/10.1182/blood-2009-12-260083.

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AbstractOsteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. The exact role of iron in the development of osteoporosis in these disorders is not established. To define the effect of iron excess in bone, we generated an iron-overloaded mouse by injecting iron dextran at 2 doses into C57/BL6 mice for 2 months. Compared with the placebo group, iron-overloaded mice exhibited dose-dependent increased tissue iron content, changes in bone composition, and trabecular and cortical thinning of bone accompanied by increas
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Eka Sari, Retno, and Wahyudi. "Iron Overload Cardiomyopathy." Sumatera Medical Journal 7, no. 3 (2024): 159–67. http://dx.doi.org/10.32734/sumej.v7i3.17796.

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Iron overload cardiomyopathy is a condition of excessive iron accumulation in cardiomyocytes due to abnormal iron absorption or repeated blood transfusion. In the early stages, the patient may be asymptomatic with good ventricular systolic function. Iron deposit in ventricular cause dyspnea on effort due to left ventricular systolic dysfunction then in atrial cause atrioventricular block and supraventricular arrhythmic. For severe symptom due to dilated cardiomyopathy is characterized by left ventricular dilatation and risk of sudden cardiac death. Diagnosis of iron overload cardiomyopathy can
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Mangaonkar, Abhishek, Niren Patel, Hongyan Xu, et al. "Plasma Biomarkers of Iron Regulation, Overload, and Inflammation in Sickle Cell Disease." Blood 124, no. 21 (2014): 1380. http://dx.doi.org/10.1182/blood.v124.21.1380.1380.

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Abstract Transfusional iron overload has been increasingly recognized among patients with sickle cell disease (SCD) over the past two decades. We recently reported on the prevalence of iron overload among 635 adult SCD patients followed at our center and found that 80 patients (12%) had developed iron overload as a result of repeated blood transfusions. Fifty six (70%) of these subjects developed iron overload as a result of episodic, mostly unnecessary transfusions at outlying hospitals. There have been reports of association of increased morbidity and mortality among iron overloaded SCD pati
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Jacobs, Allan, and A. V. Hoffbrand. "Iron deficiency and iron overload." Critical Reviews in Oncology/Hematology 3, no. 2 (1985): 143–86. http://dx.doi.org/10.1016/s1040-8428(85)80023-8.

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Díez-López, Carles, Josep Comín-Colet, and José González-Costello. "Iron overload cardiomyopathy." Current Opinion in Cardiology 33, no. 3 (2018): 334–40. http://dx.doi.org/10.1097/hco.0000000000000511.

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Camaschella, Clara. "Treating Iron Overload." New England Journal of Medicine 368, no. 24 (2013): 2325–27. http://dx.doi.org/10.1056/nejmcibr1304338.

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Dissertations / Theses on the topic "Iron overload"

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Chua-anusorn, Wanida. "Iron oxide deposits in iron overload diseases." Thesis, Chua-anusorn, Wanida (1997) Iron oxide deposits in iron overload diseases. PhD thesis, Murdoch University, 1997. https://researchrepository.murdoch.edu.au/id/eprint/52151/.

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Iron overload diseases such as thalassaemia are a major public health problem in many parts of the world. Excess iron deposited in such tissues occurs in the form of ultrafine particles of iron oxyhydroxide. At low levels of iron loading, the iron(III) oxyhydroxide particles are mostly found in the iron storage protein, ferritin. At higher levels of loading, iron(III) oxyhydroxide particles are found in insoluble aggregates known as haemosiderin. Three different structures of these iron deposits are known: (i) ferrihydrite (5Fe203.9H20), (ii) poorly crystalline goethite (α-FeOOH), and (iii) no
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Baptista-Hon, Daniel Tomas. "Cellular substrates of iron overload cardiomyopathies." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/15878.

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Cardiomyopathies and arrhythmias are major causes of death in untreated hereditary haemochromatosis, acute iron poisoning and during secondary iron overload resulting from repeated blood transfusions in β-thalassaemia. Iron overload cardiomyopathies are associated with systolic and diastolic dysfunction, suggesting that Ca2+ homeostasis is impaired. However, the cellular mechanisms of these dysfunctions are unknown. The data presented in this thesis establishes for the first time iron effects on cardiomyocyte Ca2+ handling, as well as the potential cellular substrates responsible for this impa
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Sarmento, Carlos V. 1980. "Assessment of new iron chelating agents for treatment of iron-overload." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116063.

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Patients with acquired iron overload require chelation therapy using either Desferal or Exjade. Iron in excess may promote free radical formation in the Fenton reaction resulting in severe injuries of heart, liver and endocrine organs. Che1ators that bind ferric iron (Fe+3) in a 1:1 complex (Desferal) sequester it more efficiently than those che1ators that form 2:1 (Exjade) complexes. We initiated synthesis of new chelators derived from the tridentate chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogs. The aim of the synthesis was to generate chelators that bind iron in a 1:1 com
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Ward, Roberta J. "Tissue damage in iron overload and alcohol toxicity." Thesis, King's College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304198.

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Mouralian, Cindy. "Evaluation of novel iron chelators for therapeutic use in secondary iron overload disorders." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33071.

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Pyridoxal isonicotinoyl hydrazone (PIH) has been described as an orally effective Fe chelator. It is both membrane permeable and plasma soluble, and has a high affinity for Fe, making it an ideal model on which to base future chelators. Ten novel ligands have been synthesized based on these attributes. Characterization experiments were performed to determine the ligands' selectivity and binding affinity for iron, their lipophilicity as both free and Fe-ligand complexes, and their stoichiometric relationship with iron. Efficacy of the chelators has been determined through their ability to effec
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Baffour, Richard. "The development of iron exchange system for the treatment of chronic iron overload /." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63195.

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Kilbarger, Amy K. "The effect of iron overload on osteoblast function in cell culture." Greensboro, N.C. : University of North Carolina at Greensboro, 2007. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=146.

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Thesis (M.S.)--University of North Carolina at Greensboro, 2007.<br>Title from PDF t.p. (viewed Feb. 29, 2008). Directed by Deborah Kipp; submitted to the School of Human Environmental Sciences. Embargoed until Dec. 20, 2008. Includes bibliographical references (p. 47-56).
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Hamilton, Jasmine La Juanie. "Innovative polymeric iron chelators with iron binding affinity and biocompatibility for the treatment of transfusional iron overload." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52624.

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Desferrioxamine (Desferal®, DFO), deferiprone (Ferriprox®, L1) and desferasirox (Exjade®, ICL-670) are clinically approved iron chelators used to treat transfusion associated iron overload, a common condition in patients with severe hemoglobin disorders like β-thalassemia, sickle-cell disease and the myelodysplastic syndromes. The poor pharmacokinetics and inefficacy of iron chelators necessitate administration of almost maximum tolerated doses to achieve adequate iron removal. This causes toxicity ranging from neurological dysfunction in DFO users, agranulocytosis and neutropenia in L1 users,
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Liu, Zu Dong. "Design of orally active iron(II) chelators." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266259.

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Stuart, Katherine Anne. "Iron overload in end-stage liver disease : mechanisms and pathophysiological significance /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18503.pdf.

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Books on the topic "Iron overload"

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Yehuda, Shlomo, and David I. Mostofsky, eds. Iron Deficiency and Overload. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-59745-462-9.

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(undifferentiated), David Smith. Iron overload and birth defects. De Montfort University, 1993.

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Barton, James C., Corwin Q. Edwards, Pradyumna D. Phatak, Robert S. Britton, and Bruce R. Bacon, eds. Handbook of Iron Overload Disorders. Cambridge University Press, 2009. http://dx.doi.org/10.1017/cbo9780511777035.

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C, Barton James, ed. Handbook of iron overload disorders. Cambridge University Press, 2010.

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Christos, Kattamis, and International Conference on Thalassemia and the Hemoglobinopathies (2nd : 1987 : Herakleion, Crete), eds. Iron overload and chelation in thalassaemia. H. Huber Publishers, 1989.

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Yehuda, Shlomo. Iron deficiency and overload: From basic biology to clinical medicine. Humana Press, 2010.

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Stobie, Shannon Blaire. The novel oral iron chelator, L1, in acute and chronic iron overload. National Library of Canada, 1993.

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1939-, Weinberg Hedy, ed. Living with hemochromatosis: Answers to questions about iron overload. Healthy Living Books, 2003.

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Handelsman, Harry. Hemoperfusion in conjunction with deferoxamine for the treatment of aluminum toxicity or iron overload in patients with end-stage renal disease. National Center for Health Services Research and Health Care Technology Assessment, U.S. Dept. of Health and Human Services, Public Health Service, 1987.

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Handelsman, Harry. Hemoperfusion in conjunction with deferoxamine for the treatment of aluminum toxicity or iron overload in patients with end-stage renal disease. National Center for Health Services Research and Health Care Technology Assessment, U.S. Dept. of Health and Human Services, Public Health Service, 1987.

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Book chapters on the topic "Iron overload"

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Angelucci, Emanuele. "Iron Overload." In The EBMT Handbook. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02278-5_46.

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Wick, Manfred, Wulf Pinggera, and Paul Lehmann. "Iron Overload." In Clinical Aspects and Laboratory — Iron Metabolism, Anemias. Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0087-5_9.

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Angelucci, Emanuele, and Anna Maria Raiola. "Iron Overload." In The EBMT Handbook. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_46.

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AbstractIron overload/toxicity is an unavoidable consequence in several diseases characterized by anemia and red blood cell transfusion requirement. Iron toxicity can impact on transplant outcome by increasing oxidative stress. Impact of iron toxicity is different in the different stages of HCT.
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Camaschella, Clara, A. Victor Hoffbrand, and Maria Domenica Cappellini. "Iron Overload." In Postgraduate Haematology. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118853771.ch4.

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Beck, Norman. "Iron Overload." In Diagnostic Hematology. Springer London, 2009. http://dx.doi.org/10.1007/978-1-84800-295-1_20.

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Wick, Manfred, Paul Lehmann, and Wulf Pinggera. "Iron Overload." In Clinical Aspects and Laboratory Iron Metabolism, Anemias. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3719-2_9.

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Camaschella, Clara, and A. Victor Hoffbrand. "Iron Overload." In Postgraduate Haematology. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444323160.ch4.

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Godbold, Michael, and Patrick D. McFarland. "Iron Overload." In Essentials of Blood Product Management in Anesthesia Practice. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-59295-0_45.

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Adams, Paul, and Heinz Zoller. "Iron Overload States." In Sherlock's Diseases of the Liver and Biliary System. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119237662.ch26.

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Adams, Paul. "Iron Overload States." In Sherlock's Diseases of the Liver and Biliary System. Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444341294.ch26.

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Conference papers on the topic "Iron overload"

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Lamtenzan-Marcos, Diego, Pilar Castellote-Huguet, Juan Antonio Romero-Martín, et al. "Multiparametric Liver Biomarker Analysis Using MR Elastography and MRI for Non-Invasive Assessment of Fibrosis, Steatosis, and Iron Overload in Patients with Non-Alcoholic Fatty Liver Disease." In 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2024. https://doi.org/10.1109/embc53108.2024.10782294.

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Lu, Q., Mf Gittos, K. Govender, and V. Kumar. "Effect of Iron Content on Corrosion Resistance of Ni-Cr-Mo Alloy Weld Overlays in H2S-containing Environments." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07629.

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Abstract Corrosion tests were carried out to determine the effect of iron content on localised corrosion and stress corrosion cracking (SCC) resistance of Ni-Cr-Mo alloy weld overlays (i.e. Alloy 625) in H2S environments. In addition, the influence of iron content on the fatigue crack growth rate (FCGR) of the weld overlay in both air and a sour environment was investigated. Weld overlays with a range of iron contents (5–36%), were examined. These weld overlays were manufactured using gas metal arc/metal inert gas (GMA/MIG) welding and gas tungsten arc/tungsten inert gas (GTA/TIG) welding tech
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Brennan, Michael S., and Roland C. Gassmann. "Laser Cladding of Nickel and Iron Base Alloys on Boiler Waterwall Panels and Tubes." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00235.

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Abstract Three industries (power generation, paper and steel) have been faced with finding means to protect and extend the operating cycles of their boilers due either to the fuel they burn, method of combustion, and/or the impact of environmental regulations. A common method to protect these tube surfaces is to use weld overlays. In coal-fired boilers with tangential or wall mounted Low NOx burners, corrosion resistant overlays are being used to lower wastage rates caused by the reduced environment above the burners. Also, in some cases high ash levels have resulted in the need for erosion re
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Bakker, W. T. "Corrosion of Iron Aluminides in HCL Containing Coal Gasification Environments." In CORROSION 1998. NACE International, 1998. https://doi.org/10.5006/c1998-98185.

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Abstract Iron aluminides, both in the form of diffusion coatings on low alloy steels, as well as in alloy or weld overlay form have generally shown excellent corrosion resistance in laboratory tests simulating gasifier and other reducing environments in energy conversion systems. However, the performance of aluminized coatings in gasifiers has generally been unacceptable. Coatings, containing up to 30%Al near the surface, were quite often totally destroyed in 2000-5000 hrs exposure. Here we report on laboratory corrosion tests to elucidate this discrepancy. Both high pressure (41 atm) and atmo
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Bryant, Jon R., and Manfred B. Rockel. "The Influence of Iron Pick-Up on the Corrosion Properties of Nicu30FE / Steel Clad Materials." In CORROSION 1989. NACE International, 1989. https://doi.org/10.5006/c1989-89066.

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Abstract The influence of iron pick-up on the corrosion properties of overlay and butt welds to NiCu30Fe/steel clad materials was investigated by electrochemical tests in aerated artificial sea water (ASTM Standard D1141-75) at 25, 50 and 80 deg. C and by exposure to sea water in a sea water test rig on Helgoland. NiCu30Fe plates with defined Fe contents between 0 and 14% were used for comparison. When the Fe was distributed homogeneously, no negative influence of the Fe on the pitting resistance was noted in aerated artificial sea water of 25 deg. C up to an Fe content of 10%. The pitting res
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Banovic, S. W., J. N. DuPont, and A. R. Marder. "Corrosion Resistance of Weldable Fe-Al Alloys in Reducing Environments." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99059.

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Abstract Low aluminum Fe-Al alloys are being investigated for use as protective coatings in reducing environments. Intermetallic compositions have already demonstrated excellent high temperature corrosion resistance in both oxidation and sulfidation environments, however, they are limited in use due to low room temperature ductility and poor weldability arising from hydrogen embrittlement Using Gas Tungsten Arc and Gas Metal Arc Welding processes, without the use of pre-heat and post weld heat treatments, a weldability regime below approximately 10 wt% Al in the overlay has been found. The hig
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Maligas, M. N., J. C. Vicic, D. C. Agarwal, and M. Köhler. "Use of a New 16% Moly Alloy for Weld Surfacing in Sour Environments." In CORROSION 1994. NACE International, 1994. https://doi.org/10.5006/c1994-94063.

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Abstract Special low iron Ni-Cr-Mo alloy 625 as a weld overlay material on low alloy steel for well head applications has been successfully used and continues to be used in the sour corrosive environments of the oil/gas industry. The presence of high chlorides, carbon dioxide and hydrogen sulfide combined with high pressures and temperatures necessitated the use of an alloy with a Pitting Resisting Equivalent as defined by PRE = % Cr + 3.3 x % (Mo) of at least 50 or greater. However, in certain sour environments and higher temperatures, alloy 625 reaches its limits and failures have been repor
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Paul, Larry, Gregg Clark, and Michael Eckhardt. "Laboratory and Field Corrosion Performance of a High Chromium Alloy for Protection of Waterwall Tubes from Corrosion in Low NOx Coal Fired Boilers." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06473.

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Abstract The use of corrosion–resistant weld overlays is now commonly used to reduce corrosion of boiler tubes in low NOx coal fired boilers. Alloys with higher chromium contents are the most resistant to corrosion in this type of service. A new alloy with high chromium has recently been introduced and has shown excellent resistance to corrosion in low NOx coal-fired environments. The new material is Alloy 33 (UNS R20033) and contains approximately 33% chromium, 32% iron and 31% nickel. The improved corrosion resistance of Alloy 33 should result in longer life of the weld overlay used to prote
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Islam, Md Aminul, Jiaren (Jimmy) Jiang, and Yongsong Xie. "Erosion-Corrosion Performance Evaluation of Different Materials for Oil Sand Application." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17748.

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Abstract Material loss due to erosion-corrosion decreases the throughput and useful life of the equipment. Simultaneous action of erosion and corrosion is responsible for the high degradation of the hydro-transport equipment. To minimize the operational cost, based on the degradation severity in a specific operation, different classes of materials are being used for different applications. Pipeline steels (i.e. plain carbon, API steels), for example, are relatively cheap and do not provide good wear resistance. These types of steels are typically used for less severe applications such as taili
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Agarwal, D. C., and W. R. Herda. "Solving Critical Corrosion Problems in Marine Environments by an Advanced Ni-Cr-Mo Alloy 59 UNSN06059." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00635.

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Abstract Even though several stainless steels and a few nickel based alloys have shown promise and are used in marine environments, under very severe crevice corrosion conditions, most of these have suffered from localized crevice attack. The search for alloys that are essentially immune to crevice corrosion attack in marine environment led the industry to increase the alloy content of nickel based alloys primarily in chromium and molybdenum. One such alloy, alloy 59 (UNS N06059) having a typical chemical composition of 59% nickel, 23% chromium, 16% molybdenum and iron levels of less than 1% a
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Reports on the topic "Iron overload"

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Yang, Ming, Youwei Wu, Tao Wang, and Wentao Wang. Iron overload, Infectious Complications and Survival In Liver Transplant Recipients: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.11.0022.

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Review question / Objective: Iron overload conditions is a well-established risk factor for infection of pathogens. The possible association of iron overload with infectious complications and prognosis of patients receiving transplants are not well understood. Condition being studied: Liver transplantation often represents a life-saving treatment for an increasing number of patients with end-stage liver disease. With the improvements in surgical techniques, immunosuppression strategies, and post-LT management of complications, the recipient mortality has steadily declined after LT. The surviva
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Templin, F., ed. The Internet Routing Overlay Network (IRON). RFC Editor, 2011. http://dx.doi.org/10.17487/rfc6179.

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Tortorelli, P. F., G. M. Goodwin, M. Howell, and J. H. DeVan. Weld-overlay iron-aluminide coatings for use in high-temperature oxidizing/sulfidizing environments. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/102150.

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Horwitz, Benjamin A., and Barbara Gillian Turgeon. Fungal Iron Acquisition, Oxidative Stress and Virulence in the Cochliobolus-maize Interaction. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7709885.bard.

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Our project focused on genes for high affinity iron acquisition in Cochliobolus heterostrophus, a necrotrophic pathogen of maize, and their intertwined relationship to oxidative stress status and virulence of the fungus on the host. An intriguing question was why mutants lacking the nonribosomal peptide synthetase (NRPS) gene (NPS6) responsible for synthesis of the extracellular siderophore, coprogen, are sensitive to oxidative stress. Our overall objective was to understand the mechanistic connection between iron stress and oxidative stress as related to virulence of a plant pathogen to its h
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Brenan, J. M., K. Woods, J. E. Mungall, and R. Weston. Origin of chromitites in the Esker Intrusive Complex, Ring of Fire Intrusive Suite, as revealed by chromite trace element chemistry and simple crystallization models. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328981.

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To better constrain the origin of the chromitites associated with the Esker Intrusive Complex (EIC) of the Ring of Fire Intrusive Suite (RoFIS), a total of 50 chromite-bearing samples from the Black Thor, Big Daddy, Blackbird, and Black Label chromite deposits have been analysed for major and trace elements. The samples represent three textural groups, as defined by the relative abundance of cumulate silicate phases and chromite. To provide deposit-specific partition coefficients for modeling, we also report on the results of laboratory experiments to measure olivine- and chromite-melt partiti
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Horwitz, Benjamin, and Barbara Gillian Turgeon. Secondary Metabolites, Stress, and Signaling: Roles and Regulation of Peptides Produced by Non-ribosomal Peptide Synthetases. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696522.bard.

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Fungal pathogens of plants produce a diverse array of small molecules. Often referred to as secondary metabolites because they were thought to be dispensable for basic functions, they may indeed have central roles as signals for the fungal cell, and in interactions with the host. We have identified more than a dozen genes encoding nonribosomal peptide synthetases (NPS) in Cochliobolusheterostrophus, the agent of southern corn leaf blight. The aim of this project was to identify roles of these genes in stress responses and signaling. The first objective was to test a complete collection of C. h
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