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Dissertations / Theses on the topic 'Isatina'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Miguel, Rodrigo Bernardi. "Alvos intracelulares e mecanismos de ação de complexos de cobre(II) ou zinco(II) oxindolimínicos com atividade antitumoral." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-20072018-091019/.

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No presente trabalho foram realizados estudos da atividade biológica de complexos imínicos de Cu(II) e Zn(II) derivados da isatina, principalmente frente a células tumorais HeLa. Sabe-se que estes complexos se ligam ao DNA, podendo causar clivagens simples e duplas na sua estrutura, em presença de peróxido de hidrogênio, através de um mecanismo predominantemente oxidativo. Os complexos de Cu(II) geram espécies reativas de oxigênio (EROs) e, além disto, atuam sobre a mitocôndria como agentes desacopladores. Sabe-se ainda que esses compostos interagem com proteínas específicas, como por exemplo
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2

Santos, Neto Messias Simões dos. "Um estudo renal das interações entre uroguanilia, urodilatina e bradicinina na presença dos bloqueadores da guanilato ciclase isatin e ODQ." reponame:Repositório Institucional da UFC, 2008. http://www.repositorio.ufc.br/handle/riufc/3727.

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SANTOS NETO, Messias Simoes. Um estudo renal das interações entre uroguanilia, urodilatina e bradicinina na presença dos bloqueadores da guanilato ciclase isatin e ODQ. 2008. 189 f. Tese (Doutorado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2008.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-09-04T16:45:44Z No. of bitstreams: 1 2007_tese_mssantosneto.pdf: 8132448 bytes, checksum: 9ad02a09231aaec89ee52dd6686537a9 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-09-05T11:32:15Z (GMT) No. of bitstr
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3

Cândido-Bacani, Priscila de Matos. "Citotoxicidade, genotoxicidade, mutagenicidade e potencial apoptótico da isatina em células de mamíferos." Universidade Estadual de Londrina. EMBRAPA. IAPAR. Centro de Ciências Biológicas. Prog. Pós-Graduação em Genética e Biologia Molecular, 2010. http://www.bibliotecadigital.uel.br/document/?code=vtls000160075.

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A isatina (1H-indole-2,3-dione) é uma molécula sintética versátil, encontrada em várias espécies de plantas medicinais. Várias propriedades farmacológicas e biológicas que podem ser benéficas à saúde humana têm sido atribuídas a isatina, incluindo anticolinesterase, anticonvulsiva, anti-inflamatóra, anti-hipertensiva, anti-hipóxia, antimicrobiana, antiviral e anticâncer. O objetivo do presente estudo foi avaliar a isatina quanto aos seus potenciais citotóxico, genotóxico e mutagênico em testes in vivo e as possíveis atividades citotóxica, mutagênica, apoptótica e antiproliferativa em testes in
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4

Monteiro, Matheus Morais de Oliveira. "Novos derivados da isatina causam vasorrelaxamento em artéria mesentérica cranial de ratos Wistar." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8067.

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Submitted by Clebson Anjos (clebson.leandro54@gmail.com) on 2016-03-30T18:39:51Z No. of bitstreams: 1 arquivototal.pdf: 1445770 bytes, checksum: 93635c33711265255604ec58e14b9042 (MD5)<br>Made available in DSpace on 2016-03-30T18:39:51Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1445770 bytes, checksum: 93635c33711265255604ec58e14b9042 (MD5) Previous issue date: 2015-08-27<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The process of discovering new drugs that act on the smooth
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5

PEREIRA, William. "Estudos cin?ticos de isatina e algumas cetonas arom?ticas frente a novas fosforilidrazonas." Universidade Federal Rural do Rio de Janeiro, 2009. https://tede.ufrrj.br/jspui/handle/jspui/1439.

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Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-02-15T17:02:45Z No. of bitstreams: 1 2009 - William Pereira.pdf: 3794972 bytes, checksum: 64fbf9758bbf44329031caf3b369b79a (MD5)<br>Made available in DSpace on 2017-02-15T17:02:45Z (GMT). No. of bitstreams: 1 2009 - William Pereira.pdf: 3794972 bytes, checksum: 64fbf9758bbf44329031caf3b369b79a (MD5) Previous issue date: 2009-10-22<br>CAPES<br>The present study has two specific phases: Early, was studied the isathine irradiation with the presence of diisopropil-phosphoril-dimethylidrazone (diisopfh), in chloroform, at room temperatu
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6

Zampirolli, Leticia Silotti. "Dialquilfosforilidrazonas derivadas de isatinas N - substitu?das com potencial atividade biol?gica." Universidade Federal Rural do Rio de Janeiro, 2009. https://tede.ufrrj.br/jspui/handle/jspui/2077.

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Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2017-10-05T11:53:08Z No. of bitstreams: 1 2009 - Leticia Silotti Zampirolli.pdf: 25893124 bytes, checksum: bd44115917dd331e511dc65cd22738a1 (MD5)<br>Made available in DSpace on 2017-10-05T11:53:08Z (GMT). No. of bitstreams: 1 2009 - Leticia Silotti Zampirolli.pdf: 25893124 bytes, checksum: bd44115917dd331e511dc65cd22738a1 (MD5) Previous issue date: 2009-05-27<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES, Brasil.<br>A series of new dialkylphosphorylhydrazones (phosphorohydrazidic acid, N?-[1,2-dihydro-2- oxo-(R1)-3H
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7

GOMES, Paulo André Teixeira de Moraes. "Planejamento estrutural, síntese e avaliação das propriedades farmacológicas de inéditas tiazolil-hidrazonas derivadas da ftalimida e da isatina." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18462.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2017-03-30T18:26:28Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE PAULO ANDRÉ.pdf: 12707088 bytes, checksum: 1ef366976f050b974da19aa9ed860831 (MD5)<br>Made available in DSpace on 2017-03-30T18:26:29Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE PAULO ANDRÉ.pdf: 12707088 bytes, checksum: 1ef366976f050b974da19aa9ed860831 (MD5) Previous issue date: 2016-07-27<br>FACEPE<br>A identificação e utilização de estruturas priv
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8

Barcelos, Rômulo Pillon. "AVALIAÇÃO DA ATIVIDADE DA ISATINA-3-N4-BENZILTIOSSEMICARBAZONA (IBTC) COMO ANTIOXIDANTE NA PROTEÇÃO DA LDL CONTRA A OXIDAÇÃO." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11203.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Several lines of evidence support the hypotheses that the oxidation of low density lipoprotein (LDL) is a proatherogenic factor. Oxidative stress is one of the causes of the overproduction of reactive species that increase the formation of oxidized LDL. Thiosemicarbazones are compounds used in anticancer, antiviral and antifungal therapy; however, their redox activities have been controversial. Thus, we tested, in vitro, the possible antioxidant activity of a thiosemicarbazone derivate, the isatin-3-N4-benzilthiosemicarbazone (IBTC
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9

Vasconcelos, Valeria de Assis. "Adição de aliltricloroestananas quirais a metilcetonas e isatinas." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248464.

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Orientador: Luiz Carlos Dias<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-14T14:19:47Z (GMT). No. of bitstreams: 1 Vasconcelos_ValeriadeAssis_M.pdf: 7596682 bytes, checksum: 65276fd66a14ce257adec53a54afb9cc (MD5) Previous issue date: 2009<br>Resumo: A preparação de álcoois homoalílicos através da adição de um reagente organometálico alílico a aldeídos é um dos processos mais importantes em síntese orgânica. O objetivo desse trabalho foi investigar o comportamento das aliltricloroestananas quirais (1, 2 e 3) em reaç
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10

Neto, Messias SimÃes dos Santos. "Um estudo renal das interaÃÃes entre uroguanilia, urodilatina e bradicinina na presenÃa dos bloqueadores da guanilato ciclase isatin e ODQ." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2231.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>IntroduÃÃo: Guanilinas, peptÃdeos natriurÃticos (ANP e urodilatina) e bradicinina estÃo implicados na fisiopatologia, com potencial terapÃutico, do metabolismo do sal e da hipertensÃo. Objetivo: Estudar o mecanismo de aÃÃo e possÃveis interaÃÃes destes peptÃdeos, pelo emprego de inibidores da guanilato ciclase isatina e ODQ. MÃtodo: Foram realizadas experiÃncias no rim isolado e perfundido de rato com ferramentas farmacolÃgicas, isatina (IS; 0,3 ou 10&#956;M) ou com ODQ (37&#956;M), nos estudos com uroguanilina (UGN; 0,3 ou 0,6&#
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11

Lima, Junior Claudio Gabriel. "Investigação da reação de Morita-Baylis-Hillman em reator de micro-ondas usando aldeídos aromáticos e isatina como eletrófilos: avaliação da atividade citotóxica em linhagem de células de leucemia promielocítica humanas (HL-60)." Universidade Federal da Paraí­ba, 2012. http://tede.biblioteca.ufpb.br:8080/handle/tede/7080.

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Made available in DSpace on 2015-05-14T13:21:18Z (GMT). No. of bitstreams: 1 Arquivototal.pdf: 11661227 bytes, checksum: e157f4398306766375669b2e52ab9310 (MD5) Previous issue date: 2012-11-14<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>In this work, we describe the investigation of the Morita-Baylis-Hillman reaction in microwave reactor, under closed vessel conditions to prepare 40 adducts, six novel, using 30 aromatic aldehydes and isatin as electrophiles and acrylonitrile (62a) , methyl acrylate (2), hydroxyethyl acrylate (62b), 2,2-dimethyl-1 ,3-dioxalyl a
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12

Gomes, Juliana Cristina 1983. "Novos catalisadores bifuncionais para a reação de Morita-Baylis-Hillman." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250245.

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Orientador: Fernando Antonio Santos Coelho<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-26T03:26:42Z (GMT). No. of bitstreams: 1 Gomes_JulianaCristina_D.pdf: 10331708 bytes, checksum: ab47fef95625c8a9b0232f0e3db6d428 (MD5) Previous issue date: 2014<br>Resumo: A reação de Morita-Baylis-Hillman (MBH) é um método atrativo para a formação de ligação carbono-carbono. Esta transformação tem atraído a atenção devido ao fato dela ser seletiva (quimio-, régio-, diastereo-, e enantio-) e ser também um método com alta economia de á
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13

Soulignac, Cécile. "Modification de l'Isatine pour la fabrication de biocapteurs." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR027/document.

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Pseudomonas Aeruginosa est un pathogène opportuniste qui adapte son comportement aux molécules présentes dans son milieu. Il augmente en virulence lorsqu’il détecte des peptides natriurétiques dans son environnement. L’isatine est une molécule qui bloque cet effet. Pour mieux comprendre sur quel récepteur l’isatine agit, la conception d’un biocapteur a été menée. Un biocapteur est un outil alliant un bioélément, réagissant spécifiquement avec une cible biologique, et un support physique permettant la transduction du signal pour le rendre mesurable. Les travaux de thèse suivants décrivent la pr
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14

Bonfiglioli, Matteo. "Addizione viniloga enantioselettiva di ossindoli a isatine." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8599/.

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In questo lavoro di tesi è stata studiata la reazione di addizione viniloga enantioselettiva di 3-alchilidenossindoli a isatine catalizzata da derivati di alcaloidi della cincona bifunzionali attraverso base catalisi e H-bonding catalisi.
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15

Gorugantula, Sobha Priyadarshini. "Syntheses of fused pyrroloheterocycles, isatins, approach towards the indole fragment of nosiheptide and a base-mediated formation of 3-hydroxycarbazoles." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10483.

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Thesis (Ph. D.)--West Virginia University, 2009.<br>Title from document title page. Document formatted into pages; contains xx, 242 p. : ill. Includes abstract. Includes bibliographical references (p. 137-145).
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16

Ijaz, A. S. "The synthesis of oxindole and isatin derivatives with potential radiosensizer activity." Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378349.

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17

Cresawn, Steven Gaines. "Genetic inquiry into vaccinia virus intermediate and late gene regulation." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010102.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 150 pages. Includes Vita. Includes bibliographical references.
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18

Weidner, Ingo. "Diastereoselektive Darstellung und Reaktionen von Tricarbonylchrom(0)-Indanon- und Tricarbonylchrom(0)-Isatin-Derivaten." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97124085X.

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19

Ntuli, Nelson Axe. "New aminoquinoline antimalarial cysteine protease inhibitors based on the isatin natural product scaffold." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/6352.

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Includes bibliographical references (leaves 120-125).<br>Many antimalarial drugs including chloroquine are no longer effective against the disease, as their efficacy has been decreased by the spread of drug resistant strains. This loss has been a major barrier to the effective treatment of malaria and has necessitated an urgent need to discover new antimalarial drugs. New 4-aminoquinoline isatin derivatives have been designed and synthesised. Isatin was used as a biologically validated starting point for the design of chemical libraries directed at the intended target due to its privileged nat
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20

Abdallah, Hagar Mahmoud. "Small Molecule Caspase Inhibitors Using Isatin and Oxindole Scaffolds and a Combinatorial Approach." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292600063.

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21

Pettinato, Alessandra. "Sintesi di nuovi diidropiranoni-spiroossindoli attraverso una sequenza tandem organocatalizzata di alchilidenossindoli ed isatine." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10010/.

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Questo studio ha condotto allo sviluppo di una nuova e altamente efficiente metodologia per la sintesi di diidropiranoni-spiroossindoli, in alte rese ed eccellenti eccessi enantiomerici. In particolare è stata condotta l’addizione viniloga enantioselettiva tra sistemi 3-alchilidenossindolici e isatine, sfruttando un catalizzatore chirale bifunzionale derivante dalla cincona, in grado di attivare mediante catalisi basica la posizione gamma del suddetto ossindolo e attraverso legame idrogeno l’isatina elettrofilica. Successivamente a questo stadio, in cui si ha la formazione del centro chirale,
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22

Chiyanzu, Idan. "Synthesis and biological evaluation of antiparasitic Cysteine protease inhibitors based on the Isatin Scaffold." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/6300.

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Includes bibliographical references.<br>Widespread drug resistance, loss of efficacy and toxicity has limited the full utilization of the current available drugs against malaria and other parasitic diseases. This necessitates the development of new drugs. Meanwhile, the cysteine protease family of enzymes has been identified as potential targets for new modes of chemotherapy due to the numerous critical roles they play in the disease-causing agents. In this project, a non-peptidic and low molecular weight isatin (indole-2, 3-dione) possessing a wide range of pharmacological properties was used
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Clay, Charles Michael. "Synthesis of Isatin Derivatives Used for the Inhibition of Pro-Apoptotic Jurkat T Cells." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1315518391.

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24

Bredenkamp, Angela [Verfasser]. "Methoden zur Synthese von 1,3-Polyolen und Isatinen / Angela Bredenkamp." Wuppertal : Universitätsbibliothek Wuppertal, 2015. http://d-nb.info/1081329076/34.

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25

Bahhitti, Meryem. "Extraction, séparation et identification des principes tinctoriaux du pastel (Isatis Tinctoria L. )." Toulouse, INPT, 1997. http://www.theses.fr/1997INPT009G.

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L'objectif de ce travail est l'extraction et la separation de deux molecules colorantes isomeres : l'indigotine et l'indirubine, issues des feuilles de pastel (isatis tinctoria l. ). Au cours de la separation sur colonne ouverte de gel de silice de ces deux molecules, le suivi de leur apparition a ete fait par hplc a detecteur uv. L'identification des deux structures moleculaires a ete faite par differentes techniques d'analyse spectroscopiques, ultra-violet, infra-rouge, rmn de proton et par spectrometrie de masse. En fin, l'etude de la solidite au lavage et a la lumiere a permis de conclure
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Fuller, Ann T. "An Autecological Study of Dyers Woad (Isatis tinctoria L.) on Utah Rangeland." DigitalCommons@USU, 1985. https://digitalcommons.usu.edu/etd/6395.

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Northern Utah rangelands have become infested with dyers woad (Isatis tinctoria L.) and control is needed. Mechanical and chemical control on rangelands produce undesirable effects. A possible alternative is biological control, but information is not available on plant response to this control method. This autecological study and simulation of control methods examined dyers woad phenology, seed endurance and response to simulated grazing, hand rogueing and plowing. The phenology study documented dyers woad growth patterns from May 1982 to November 1983. During the first year, 65 percent of the
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Selchow, Sabine U. "The 'global'-isation of politics : a theorisation of the omnipresence of 'global' in contemporary discourses." Thesis, London School of Economics and Political Science (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599955.

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Uribe, Ordonez Lalita Shaki [Verfasser]. "Molecular dynamics study of the mechanical properties of foldamers and the metal specificity of an isatin hydrolase / Lalita Shaki Uribe Ordonez." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1123040125/34.

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Montaut, Sabine. "Composition phytochimique et évaluation de potentialités biologiques des fruits de Isatis tinctoria L. (Brassicaceae)." Toulouse, INPT, 1999. http://www.theses.fr/1999INPT004C.

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Isatis tinctoria l. Ou pastel (brassicaceae) est une plante tres commune dans le sud de la france et dans les pays mediterraneens. Cette plante est connue, depuis des siecles, pour sa propriete tinctoriale bleue due a des precurseurs d'indigo : isatan b et indican. La premiere partie bibliographique donne une breve presentation des brassicaceae, de isatis tinctoria l. , de ses utilisations, de la composition chimique et des proprietes de la plante. La deuxieme partie est consacree a une analyse phytochimique des fruits du pastel. Nous avons isole et identifie, grace aux donnees spectrales uv,
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Matadamas-Ortiz, Elías-Jaime. "Étude et caractérisation des matières colorantes du pastel (Isatis tinctoria L. ) : détermination des conditions optimales d'extraction pour leur utilisation à l'échelle industrielle." Toulouse, INPT, 2002. http://www.theses.fr/2002INPT038G.

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Fréchard, Antoine. "Contribution à l'étude des glucosinolates de Isatis tinctoria L. Et de Cardaria draba (L. ) Desv." Toulouse, INPT, 2002. http://www.theses.fr/2002INPT010A.

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Ce Travail est consacré à l'étude des glucosinolates de deux espèces végétales : Isatis tinctoria L. Et Cardaria draba (L. ) Desv. Ces métabolites secondaires de plante sont des thioglucosides sulfatés à l'origine de l'odeur et du goût piquant de certains légumes tels que le chou ou le radis. Parmi les dix glucosinolates isolés et identifiés des graines de Isatis tinctoria L. , quatre sont des produits naturels nouveaux : la glucoisatisine, l'épi-glucoisatisine, la 3'-hydroxyglucoisatisine et la 3'-hydroxyépi-glucoisatisine. Ils combinent un aglycone aliphatique et indolique, et peuvent être,
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32

Farah, Kassim O. "Autecological and Grazing Control Studies of Dyers Woad (Isatis tinctoria L.) on Northern Utah Rangelands." DigitalCommons@USU, 1987. https://digitalcommons.usu.edu/etd/6448.

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Dyers woad (Isatis tinctoria L.) is a noxious weed on northern Utah rangelands. Chemical and mechanical means of control are unsuitable for rangelands. A potential alternative, biological control, is difficult due to a lack of basic ecological information. To remedy this, some aspects of the population biology and autecolgy of dyers woad were studied. The feasibility of controlling dyers woad by early spring grazing was also investigated via clipping experiments. A population study followed the survivorship of experimentally established populations over two years. Fall germinating individuals
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33

Lander, Dorothy Agnes. "Telling tales out of school : author-ising the university as a service organ-isation for first year students." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339604.

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34

Stoker, Kerry G. "The cultivation of woad (Isatis tinctoria) for production of natural indigo : agronomy, extraction and biochemical aspects." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389423.

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35

Sagwan-Barkdoll, Laxmi. "Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/dissertations/1553.

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Plants are abundant in cytochrome P450s constituting about 1% of their protein coding genes. Some of these P450s catalyze oxidation reactions in metabolic pathways that lead to valuable compounds, like the anticancer drug paclitaxel, the blue pigment indigo and the promising antileukemic agent indirubin. The promiscuous nature of P450 catalysis enables simultaneous production of indirubin and indigo from a common substrate, but it also decreases the yield of paclitaxel in both plants and heterologous hosts, respectively. In this thesis, the catalytic promiscuity of CYP725A4 from Taxus cuspidat
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Multani, Parminder Singh. "PRODUCTION OF INDIGOIDS BY ESCHERICHIA COLI EXPRESSING TRYPTOPHAN SYNTHASE-LIKE AND P450 GENES FROM ISATIS TINCTORIA L." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1684.

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Isatis tinctoria L. (woad) is a natural source of the anticancer compound indirubin, as well as the related precursors for this and other indigoid compounds like indigo. Indirubin and indigo are produced from the dimerization of indoxyl molecules, which are products of hydrolysis of glycosylated indigoid precursors present in woad and other indigo-producing plants. The plant biosynthesis of indigoid precursors is not yet completely understood due to the lack of information on enzymes responsible for formation and oxidation of indole, which is the starting molecule for indigoid biosynthesis. Th
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MELO, Maria Carolina de Araújo. "Estudo teórico conformacional da delta-toxina e teórico-experimental da interação de complexos de cobre-base de Schiff com o canal iônico da alfa-toxina de Staphylococcus aureus/." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17167.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-06-28T17:52:25Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Melo-MCA_dissertacao.pdf: 6271738 bytes, checksum: ce55245b114aac78286d16fa3cabf5d4 (MD5)<br>Made available in DSpace on 2016-06-28T17:52:25Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Melo-MCA_dissertacao.pdf: 6271738 bytes, checksum: ce55245b114aac78286d16fa3cabf5d4 (MD5) Previous issue date: 2015-07-12<br>CAPES<br>O Staphylococcus (S.) aureus é responsável por i
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38

Ding, Kai. "DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS AGAINST BOTH HUMAN AND MOUSE MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 ENZYMES." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/102.

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As the principal pro-inflammatory prostanoid, prostaglandin E2 (PGE2) serves as mediator of pain and fever in inflammatory reactions. The biosynthesis of PGE2 starts from arachidonic acid (AA). Cyclooxygenase (COX)-1 and/or COX-2 converts AA to prostaglandin H2 (PGH2), and PGE2 synthases transform PGH2 to PGE2. Current mainstream approach for treating inflammation-related symptoms remains the application of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and selective COX-2 inhibitors (coxibs). As both categories shut down the biosynthesis of all downstream prostanoids, their appli
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Ulker, Emine Buket. "Stochastic Approach In Reserve Estimation." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/1091669/index.pdf.

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Geostatistics and more specifically stochastic modeling of reservoir heterogeneities are being increasingly considered by reservoir analysts and engineers for their potential in generating more accurate reservoir models together with usable measures of spatial uncertainty. Geostatistics provides a probabilistic framework and a toolbox for data analysis with early integration of information. The uncertainty about the spatial distribution of critical reservoir parameters is modeled and transferred all the way to a risk conscious reservoir management. The stochastic imaging (modeling) algorithms
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40

Nguyen, Thi Kieu Oanh. "Analyse métabolomique de Isatis tinctoria L. Et de Datura innoxia Mill. : utilisation des réseaux de corrélation pour l'étude de la biosynthèse de molécules à usage pharmaceutique." Amiens, 2013. http://www.theses.fr/2013AMIE0107.

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Datura innoxia Mill. Et Isatis tinctoria L. Sont deux plantes médicinales d'intérêt pharmaceutique. Chez D. Innoxia Mill. , notre étude métabolomique a porté sur les racines de plantes entières ayant subi ou non une co-culture préalable avec Agrobacterium rhizogenes. Nos analyses GC-MS et UPLC-MS ont permis l'identification de 50 alcaloïdes connus et 2 nouveaux. L'analyse des réseaux de corrélation entre métabolites a révélé des étapes contrôlant la vitesse dans la biosynthèse de l'hyoscyamine et de la scopolamine et des alcaloïdes dérivés. Des spécificités induites par la transformation génét
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41

Iba, Naïma. "Les esters d'acides gras polyinsaturés d'Isatis tinctoria (pastel) : mise au point d'une technique de séparation : généralisation à différentes huiles insaturées." Toulouse, INPT, 1990. http://www.theses.fr/1990INPT023G.

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La mise au point d'une technique de separation des esters methyliques d'acides gras polyinsatures issus de l'huile de pastel, sur des resines echangeuses d'ions sous forme ag#+ en presence de differents solvants comme eluants, fait l'objet du present travail. Apres une approche bibliographique sur le role biologique des acides gras polyinsatures, l'etude de l'extraction et de la neutralisation de l'huile par esterification in situ des acides gras libres en presence de resines echangeuses d'ions et du methanol anhydre, suivie de la transesterification a montre que l'huile de pastel peut constit
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42

Thomas, Elizabeth. "Expression Analysis of Plant Defense Responses during the Establishment of Biotrophy and Role of Abiotic Stress in the Infection of Dyer’s Woad (Isatis tinctoria) by Puccinia thlaspeos." DigitalCommons@USU, 2008. https://digitalcommons.usu.edu/etd/122.

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The kinetics and amplitude of the salicylic acid-responsive pathogenesis-related (PR) genes and the cytochrome P450 gene ItCYP79B2 in the compatible interaction between Puccinia thlaspeos and dyer’s woad (Isatis tinctoria) during the first 72 hours of inoculation were examined. Immediately following penetration of the host by the rust pathogen, there was a modest up-regulation of PR genes but a significant down-regulation of ItCYP79B2 expression. During haustoria formation, a significant pathogen-mediated suppression of PR genes was observed with a corresponding up-regulation of ItCYP79B2. Thi
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Kruger, Johanna Aletta. "Die begeleidingsrol van ouers met kinders wat leerobstruksies ondervind / Johanna Aletta Kruger." Thesis, North-West University, 2003. http://hdl.handle.net/10394/7848.

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Every person (also the learner) has a need to fulfill his full potential. To be successful in fulfilling one's potential, the learner needs the accompaniment of an adult, as no person can reach selfactualisation without this accompaniment. The way in which the adult (parent) accompanies the learner, is of utmost importance. If the parent commits an educational error by not putting the educational essences into practice, it can lead to intrinsic barriers to learning, which manifests as learning problems, or specific educational needs, in a learner. Research was conducted to determine the accomp
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Stucchi, M. "MULTICOMPONENT APPROACHES TO THE SYNTHESIS OF SMALL BIOACTIVE MOLECULES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330951.

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In this PhD thesis, we exploited the potentialities of four different multicomponent reactions (MCRs), namely Ugi four-component reaction (U-4CR), N-split Ugi reaction (N-split U-4CR), van Leusen three-component reaction (vl-3CR) and Biginelli reaction (Bg-3CR), developing five different approaches to the synthesis of small bioactive molecules. In particular, we successfully applied the build/couple/pair strategy obtaining a small library of ketopiperazine-based minimalist peptidomimetics, by means of diastereoselective U-4CR/post-cyclization sequences, employing optically pure amino acid-de
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Khodabocus, Nooreeda. "Grammaire de l'infinitif injonctif." Thesis, Artois, 2016. http://www.theses.fr/2016ARTO0012.

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L’infinitif est souvent présenté comme un mode qui ne présente ni les marques de temps, ni de personne, ni de nombre. De ce fait, la grammaire traditionnelle le classe parmi les formes non personnelles du verbe avec le gérondif et le participe. Cependant, l’infinitif sert à exprimer un ordre, un conseil, une interdiction, entre autres actes directifs. On le retrouve dans les modes d’emploi de divers produits, dans les recettes de cuisine, dans le code de la route, dans les libellés de conseil, pour ne citer que quelques exemples. Selon les grammaires, dans cet emploi, l’infinitif serait utilis
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Fernandes, Isabel Patrícia Garrido. "Mecanismos eletroquímicos de derivados da isatina e de proteínas membranares calmodulina e caveolinas." Doctoral thesis, 2017. http://hdl.handle.net/10316/42245.

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Tese de doutoramento em Química, na especialidade de Eletroquímica, apresentada ao Departamento de Química da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Os mecanismos eletroquímicos da isatina e de trinta compostos indólicos derivados da isatina, que possuem um amplo perfil farmacológico, e das proteínas membranares calmodulina e caveolinas 1, 2, 3, foram investigados utilizando técnicas voltamétricas, no elétrodo de carbono vítreo. Estas moléculas estão interligadas ao nível biológico, uma vez que a calmodulina, que tem um papel fundamental na sinalização e regulação dos
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Fernandes, Isabel Patrícia Garrido. "Mecanismos redox e electroanálise de fármacos: Temozolomida, Clioquinol, Daidzéina e Azo-derivados da isatina." Master's thesis, 2012. http://hdl.handle.net/10316/20505.

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O objetivo deste trabalho foi investigar o comportamento redox de compostos farmacêuticos, nomeadamente a temozolomida (TMZ), o clioquinol (CQ), a daidzeína (DZ) e de um grupo de compostos azotados derivados da isatina (ISA), todos com diferentes aplicações farmacoterapêuticas, entre as quais antineoplásicas, antifúngicas e antioxidantes, utilizando um elétrodo de carbono vítreo (GCE) e os métodos voltamétricos de voltametria cíclica, de impulso diferencial e de onda quadrada. O mecanismo de redução da TMZ é um processo controlado por difusão, irreversível, dependente do pH e ocorre num
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Liu, Pei-Jun, and 柳沛君. "Phosphine-Catalyzed Reaction of Ynenoates with Isatins." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/r4rt5h.

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Li, Chia-Hsiu, and 李佳修. "Study toward Isatin Derivatives by Multicomponent Reactions." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/69wy3t.

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Muschalek, Bianka [Verfasser]. "Tricarbonylchrom(0)-Komplexe des Isatins und strukturverwandter Stoffe / von Bianka Muschalek." 2008. http://d-nb.info/992044898/34.

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