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Journal articles on the topic 'Isatina'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Silva, Bianca N. M. da, Renato S. Bastos, Bárbara V. Silva, and Angelo C. Pinto. "Síntese de 5-nitro-isatina e 5-cloro-isatina a partir da isonitrosoacetanilida." Química Nova 33, no. 10 (2010): 2279–82. http://dx.doi.org/10.1590/s0100-40422010001000043.

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2

Karla, Leonardo Eremita, Chagas da Silveira Vivian, and Antonio Favero Filho Luiz. "AVALIAÇÃO DA ATIVIDADE ANTIMICROBIANA DE COMPLEXOS DE ISATINA." Revistaft 28, no. 132 (2024): 30. https://doi.org/10.5281/zenodo.10800830.

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<em>O crescente número de bactérias resistentes a antibióticos e o surgimento constante de novas doenças, tem sido motivo de muita preocupação no mercado químico-farmacêutico. A busca por novos compostos que possam atuar contra essas resistentes bactérias é emergencial, diante disso, esse projeto testou o complexo de Isatina em duas formulações: complexos (S)-4-metilbenzil cisteína + Isatina + Perclorato de cobre e complexo (S)-4-clorobenzil cisteína + Isatina + Perclorato de cobre,  frente a

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3

Justo-Cousiño, Lorenzo A., Lilian Faro, and Rafael Durán. "Isatina, un compuesto endógeno a considerar en la Enfermedad de Parkinson." Revista Peruana de Investigación en Salud 5, no. 2 (2021): 140–41. http://dx.doi.org/10.35839/repis.5.2.928.

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4

Sonawane, Ratnamala P., and Rahul R. Tripathi. "The Chemistry and Synthesis of 1H-indole-2,3-dione (Isatin) and its Derivatives." International Letters of Chemistry, Physics and Astronomy 12 (September 2013): 30–36. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.12.30.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds. In this, a convenient method has been developed for the conversion of Indoles into Isatins and some heterocyclic derivative were synthesised such as 5- nitro-1H-indole-2,3-dione, 2-methylquinoline-4-carboxylic acid which may be used as raw material for drug synthesis. The general process utilizes the effective method for synthesis of Isatin from Indole is bromination and oxidation with an N-bromosuccinimide-dimethyl sulfoxide reagent. The nitration of Isatin at

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5

Sonawane, Ratnamala P., and Rahul R. Tripathi. "The Chemistry and Synthesis of 1H-indole-2,3-dione (Isatin) and its Derivatives." International Letters of Chemistry, Physics and Astronomy 12 (April 20, 2013): 30–36. http://dx.doi.org/10.56431/p-8lif75.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds. In this, a convenient method has been developed for the conversion of Indoles into Isatins and some heterocyclic derivative were synthesised such as 5- nitro-1H-indole-2,3-dione, 2-methylquinoline-4-carboxylic acid which may be used as raw material for drug synthesis. The general process utilizes the effective method for synthesis of Isatin from Indole is bromination and oxidation with an N-bromosuccinimide-dimethyl sulfoxide reagent. The nitration of Isatin at

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6

Fonseca, Alexandra de Souza, Gisele Louro Peres, Tomás Garcia Storino, et al. "Síntese e caracterização estrutural do ligante isatina-3-(N4-benziltiossemicarbazona) e do seu complexo de mercúrio(II)." Química Nova 33, no. 7 (2010): 1453–56. http://dx.doi.org/10.1590/s0100-40422010000700006.

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7

Mehreen, Saba, Aman Ullah, Humaira Nadeem, Necmi Dege та Muhammad Moazzam Naseer. "Synthesis, solid state self-assembly driven by antiparallel π⋯π stacking and {⋯H–C–C–F}₂ dimer synthons, and in vitro acetyl cholinesterase inhibition activity of phenoxy pendant isatins". RSC Advances 12, № 3 (2022): 1788–96. http://dx.doi.org/10.1039/d1ra08286h.

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The phenoxy pendant isatins were observed to be highly potent inhibitors of acetylcholinesterase. In addition, the solid-state structure of a phenoxy pendant isatin showed an intriguing 1D-supramolecular self-assembled structure.

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8

Tripathi, Rahul R., and Ratnamala P. Sonawane. "An Extraction of the Isatin from the Couroupita guianesis (Cannon Ball Tree) and a Novel Synthesis of the N,N'-(2-oxo-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazole]-3',5'-diyl]diacetamidefrom the Isatin." International Letters of Chemistry, Physics and Astronomy 15 (September 2013): 119–25. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.15.119.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of Isatins and heterocyclic compounds. In this, the isatin were extracted from the floral material of Couroupita guianesis commonly known as an Cannon ball tree. After that, a novel heterocyclic spiro derivative having an IUPAC name N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthesized , which may be used as raw material for drug synthesis. A spiro compound N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthe

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9

Tripathi, Rahul R., and Ratnamala P. Sonawane. "An Extraction of the Isatin from the <i>Couroupita guianesis</i> (Cannon Ball Tree) and a Novel Synthesis of the N,N'-(2-oxo-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazole]-3',5'-diyl]diacetamidefrom the Isatin." International Letters of Chemistry, Physics and Astronomy 15 (June 29, 2013): 119–25. http://dx.doi.org/10.56431/p-h7k957.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of Isatins and heterocyclic compounds. In this, the isatin were extracted from the floral material of Couroupita guianesis commonly known as an Cannon ball tree. After that, a novel heterocyclic spiro derivative having an IUPAC name N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthesized , which may be used as raw material for drug synthesis. A spiro compound N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthe

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10

Tabatabaeian, Khalil, Manouchehr Mamaghani, Nosratollah Mahmoodi, and Alireza Khorshidi. "Ruthenium-catalyzed efficient routes to oxindole derivatives." Canadian Journal of Chemistry 87, no. 9 (2009): 1213–17. http://dx.doi.org/10.1139/v09-098.

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Ruthenium-catalyzed preparation of oxindoles from one-pot trimerization of indoles under oxidative conditions and from electrophilic substitution reaction of indoles with isatins or isatin-derived imines under very mild reaction conditions is reported.

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11

Ortiz-Espinoza, Jesús, and Manuel Aguilar-Vega. "Modificación estructural de polímeros bifenilen-isatina y su aplicación en membranas CMM: Efecto en las propiedades de transporte." Transdigital 4, no. 8 (2023): 1–16. http://dx.doi.org/10.56162/transdigital220.

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Las membranas de Carbón de Malla Molecular (MCMM) presentan excelentes propiedades químicas y térmicas, superan fácilmente la típica compensación entre permeabilidad y selectividad en procesos de separación de gases. Sin embargo, el rendimiento y los mecanismos de transporte involucrados en la separación no están muy claros. Los principales polímeros precursores para la síntesis de MCMM están limitados a resinas fenólicas, poliimidas y estructuras altamente aromáticas. Lo anterior, abre la oportunidad para explorar nuevos materiales poliméricos como precursores. Por ejemplo, las diferentes var

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12

Gandhi, Priyanka V., Shubham R. Burande, Manoj S. Charde, and Rita D. Chakole. "A REVIEW ON ISATIN AND ITS DERIVATIVES: SYNTHESIS, REACTIONS AND APPLICATIONS." Journal of Advanced Scientific Research 12, no. 04 (2021): 1–11. http://dx.doi.org/10.55218/jasr/2021.12401.

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Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin in 1840, before it was discovered in nature. It is versatile and distributed in tissues and body fluids. Isatins have also been detected in mammalian tissue, and their function as a biochemical process modulator has been the focus of many debates. The isatin moiety also shows some important chemical reactions such as oxidation, N-Acylation, Friedel-Crafts reaction, N-Halogenation, etc. Antitumor, antimicrobial, anti-inflammatory, anticonvulsant,

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13

Salvanna, N., Perla Ramesh, K. Santosh Kumar, and Biswanath Das. "Copper-catalyzed aerobic oxidative intramolecular amidation of 2-aminophenylacetylenes: a domino process for the synthesis of isatin." New Journal of Chemistry 41, no. 22 (2017): 13754–59. http://dx.doi.org/10.1039/c7nj02441j.

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A novel CuI-catalyzed oxidative amidation of 2-aminophenylacetylenes leading to the formation of isatins by using open air as an oxygen source has been developed. The reaction proceeded smoothly and provided a variety of isatin derivatives in good yields.

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14

Zhao, Hong-Wu, Xiao-Qin Chen, Zhao Yang, et al. "Highly diastereoselective synthesis of imidazolidine-dispirooxindoles via three-component [3 + 2] cycloadditions of isatins, 2-(aminomethyl)pyridine and isatin-based imines." RSC Advances 5, no. 125 (2015): 103116–22. http://dx.doi.org/10.1039/c5ra21995g.

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In the presence of Et<sub>3</sub>N, the [3 + 2] cycloaddition of isatins, 2-(aminomethyl)pyridine and isatin-based imines proceeded readily, and furnished novel imidazolidine-dispirooxindoles in up to 84% yield with up to >99 : 1 diastereoselectivity.

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15

G., Nagaraju 1. *. Dr. Anil Kumar 2. "SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITIES OF OXADIAZOLE DERIVATIVE." Journal of Pharma Research 7, no. 6 (2018): 96–98. https://doi.org/10.5281/zenodo.1291605.

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<strong><em>ABSTRACT</em></strong> <strong><em>I</em></strong><em>satin chemically known as 1H-indole-2,3-dione. It is a unique molecule possessing both amide and keto carbonyl groups. Isatin and its derivatives having several pharmacological actions. In the present study some Isatins derivatives have been synthesized.  The chemical structures of the synthesized compounds were confirmed by using spectral and elemental analysis methods and developed some pharmacological evaluations.</em> <strong><em>KEY WORDS:</em></strong><em> Isatins, Pharmacological actions,<strong> </strong>Oxadiazole

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16

Santoso, Mardi, Arif Fadlan, Muhammad Riza Ghulam Fahmi, and Ardhana Rahmayanti. "Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line." Open Chemistry 19, no. 1 (2021): 199–204. http://dx.doi.org/10.1515/chem-2021-0023.

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Abstract This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.

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17

Bogdanov, Andrei V., Margarita Neganova, Alexandra Voloshina, et al. "Anticancer and Antiphytopathogenic Activity of Fluorinated Isatins and Their Water-Soluble Hydrazone Derivatives." International Journal of Molecular Sciences 24, no. 20 (2023): 15119. http://dx.doi.org/10.3390/ijms242015119.

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A series of new fluorinated 1-benzylisatins was synthesized in high yields via a simple one-pot procedure in order to explore the possible effect of ortho-fluoro (3a), chloro (3b), or bis-fluoro (3d) substitution on the biological activity of this pharmacophore. Furthermore, the new isatins could be converted into water-soluble isatin-3-hydrazones using their acid-catalyzed reaction with Girard’s reagent P and its dimethyl analog. The cytotoxic action of these substances is associated with the induction of apoptosis caused by mitochondrial membrane dissipation and stimulated reactive oxygen sp

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18

Pathak, Ashutosh, P. Malairajan Arti Gautam, and Shibu Das. "Isatin: A Short Review of their Antimicrobial Activities." International Journal of Current Microbiology and Applied Sciences 11, no. 1 (2022): 61–77. http://dx.doi.org/10.20546/ijcmas.2022.1101.009.

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Isatin(2, 3-dioxindate), a particularly effective scaffold with a variety of pharmacological actions, has been developed due to its therapeutic significance in organic and medicinal chemistry. Many researchers have been drawn to this skeleton because of its diverse biological response profile and its multiple possibilities against a variety of activities. Sandmeyer's and Stolle processes are two typical ways for synthesizing isatin derivatives. Many researchers have taken advantage of the isatin moiety by using NH at the first position, C2 and C3 carbonyl positions for the creation of numerous

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19

Cheke, Rameshwar S., Vaishali M. Patil, Sandip D. Firke, et al. "Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery." Pharmaceuticals 15, no. 3 (2022): 272. http://dx.doi.org/10.3390/ph15030272.

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Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, anticonvulsant, anti-HIV, and so on. Many research chemists take advantage of the gentle structure of isatins, such as NH at position 1 and carbonyl functions at positions 2 and 3, for designing biologically active analogues via different approaches. Literature surveys

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20

Ma, Zhiyuan, Feng Ni, Grace H. C. Woo та ін. "An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines". Beilstein Journal of Organic Chemistry 8 (6 червня 2012): 829–40. http://dx.doi.org/10.3762/bjoc.8.93.

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Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.

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21

Bogdanov, A. V., A. D. Voloshina, S. K. Amerkhanova, et al. "Biologically active symmetric and asymmetric dicationic <i>bis</i>-isatinhydrazones: which is better - complicing or simplifying the structure of the spacer?" Журнал органической химии 59, no. 11 (2023): 1387–409. http://dx.doi.org/10.31857/s0514749223110010.

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The interaction of bis-isatins containing a 1,-ω-alkylene, arylene, or alkyluracil spacer with ammonium acetohydrazides yielded a series of dicationic isatin-3-acylhydrazones with symmetric and asymmetric structures. It was shown that the antimicrobial activity of the new compounds depends on the structure of the spacer and the nature of the substituent in the aromatic fragment. Derivatives based on 5-substituted isatins, in which heterocyclic fragments are linked by an alkylene chain of 9 and 10 carbon atoms, exhibit a bactericidal effect against resistant strains of Staphylococcus aureus at

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22

Kosaraju Lahari and Raja Sundararajan. "Isatin – a potent anti-microbial agent." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 955–70. http://dx.doi.org/10.26452/ijrps.v10i2.367.

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From many years in hospitalized and ambulatory patients, it is observed that increased antibiotic resistance in both Gram-positive and Gram-negative bacteria. For global health, a significant threat was found to be quick development of resistance by various microorganisms against anti-microbial drugs. In addition, multidrug-resistant organisms also developing rapidly which further complicated the situation. Hence it is necessary to develop and find out novel anti-microbial agent urgently. In the field of organic chemistry important role was played by heterocyclic compounds. They are acquiring

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23

Nazeer, Elham, Aswany U R, and Shaiju S Dharan. "2, 3-Dioxoindoline Derivatives: Synthesis, Reactions and Exploring Pharmacological Activities." International Journal of Research and Review 9, no. 12 (2022): 109–23. http://dx.doi.org/10.52403/ijrr.20221212.

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Heterocyclic compounds represent an important class of organic compounds having vivid biological and pharmacological properties. These heterocyclic moieties, either individually or in fused form, are continuously used by researchers for the creation of new drugs due to their extensive biological profile. Isatin (1 H - indole-2,3-dione), also known as (2,3- dioxoindoline, indole quinine and indenedione), exhibits a broad range of biological activity and is therefore regarded as a bio-active heterocyclic moiety. Isatin derivatives are synthesized by using two common methods such as Sandmeyer’s a

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24

Shanmugam, Ponnusamy, and Vadivel Vaithiyanathan. "Activation of the NC–H bond of Morita–Baylis–Hillman adducts of N-substituted isatins with cerium ammonium nitrate (CAN) and alcohol (ROH)." Canadian Journal of Chemistry 87, no. 4 (2009): 591–99. http://dx.doi.org/10.1139/v09-020.

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A study on the activation of the NC–H bond of Morita–Baylis–Hillman adducts of N-substituted isatin with cerium ammonium nitrate (CAN) and saturated and unsaturated alcohols have been carried out. The choice of a Morita–Baylis–Hillman adduct for this study is screened with a number of adducts. A comparative and reactivity pattern study on NC-H activation of Morita–Baylis–Hillman adducts of N-substituted isatin derivatives viz. N-methyl, N-ethyl, N-methyl acetate, N-benzyl, N-propargyl, and N-isopropyl isatins have been carried out. Effect of aryl ring substitution has also been investigated. A

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25

Fu, Qin, and Chao-Guo Yan. "Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction." Beilstein Journal of Organic Chemistry 9 (May 13, 2013): 918–24. http://dx.doi.org/10.3762/bjoc.9.105.

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A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst. When two equivalents phenacyl bromides were used in the reaction, the N-substitution reaction of isatin also finished with the formation of spiro-oxirane-oxindoles.

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26

Jagadeesh, R. "Mechanistic investigations of oxidation of isatins by sodium N-chlorobenzenesulfonamide in alkaline medium: A kinetic study." Open Chemistry 3, no. 3 (2005): 482–501. http://dx.doi.org/10.2478/bf02479277.

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AbstractOxidation of isatins (isatin, 5-methylisatin, 5-bromoisatin and 5-nitroisatin) to their anthranilic acids was performed efficiently with sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) in alkaline medium at 35±0.1°C. The reactions follow identical kinetics for all the isatins, being first-order dependence each in [CAB]o and [Isatin]o and inverse fractional-order on [NaOH]. Addition of halide ions and benzenesulfonamide, reduction product of CAB, do not significantly affect the rate. Variation of ionic strength of the medium had no effect on the rate, while the dielectric effect

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27

Wang, Qinggang, Xianhui Zhang, Li Zhou, Qaiser Mahmood, Mengmeng Zhao, and Xiaowu Wang. "1,5,7-Triazabicylodec-5-ene-Promoted Direct Vinylogous Aldol Reaction for the Synthesis of 3-Hydroxy-2-oxoindole Derivatives." Synlett 30, no. 05 (2019): 573–76. http://dx.doi.org/10.1055/s-0037-1612107.

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A simple and efficient method has been developed for the synthesis of 3-hydroxy-2-oxoindole derivatives through a direct vinylogous aldol reaction of allylic esters with isatins, catalyzed by 1,5,7-triazabicyclodec-5-ene. This method affords a variety of 3-hydroxy-2-oxoindole derivatives in moderate to excellent yields with high regioselectivities. An asymmetric version of this reaction catalyzed by Corey’s chiral guanidine proceeded with moderate enantioselectivity. The protocol can also be used to synthesize isatin spiro ethers.

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28

Arvind, Umarkar, Rathi Radhika, Parhad Pravin, Mapari Mangesh, and Shah Sapan. "Isatin as a Novel Anticancer Agent: Mechanisms and Potential in Breast Cancer Treatment." Journal of Research and Reviews in Yoga & Ayurvedic Sciences 2, no. 2 (2025): 1–12. https://doi.org/10.5281/zenodo.15423991.

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<em>Isatin (1H-indole-2,3-dione) is a naturally occurring molecule having </em>a range of<em> </em><em>pharmacological alterations, especially anti-cancer effects. Recent research has emphasized its potential as an anti-breast cancer drug, owing </em><em>to</em> <em>ability to decrease tumor cell growth, induce apoptosis, and modify critical signaling pathways involved in cancer progression. Isatin works through a range of processes, including angiogenesis inhibition, metastasis suppression, and cell cycle control. Furthermore, its capacity to interact with biological pathways such as the PI3K

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29

Sluyter, Ronald, та Kara L. Vine. "N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1βRelease from Murine Macrophages". Mediators of Inflammation 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2097219.

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Extracellular adenosine 5′-triphosphate (ATP) activates the P2X7 receptor channel to induce the rapid release of the proinflammatory cytokine, interleukin- (IL-) 1β, from macrophages. Microtubule rearrangements are thought to be involved in this process. Some isatin derivatives alter microtubules and display anticancer activities. The current study investigated the effect of isatin and seven structurally diverse isatin derivatives on P2X7-mediated IL-1βrelease from murine J774 macrophages. ATP-induced IL-1βand lactate dehydrogenase (LDH) release were assessed by specific colorimetric assays. P

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30

Xiao, Zi-Ying, Jing Sun, and Chao-Guo Yan. "Molecular diversity of the reactions of MBH carbonates of isatins and various nucleophiles." Beilstein Journal of Organic Chemistry 21 (February 6, 2025): 286–95. https://doi.org/10.3762/bjoc.21.21.

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In this paper, the nucleophilic substitution reactions of various N- and P-containing nucleophiles to MBH carbonates of isatins were investigated. Diverse functionalized 3-substituted oxindole derivatives were successfully prepared in satisfactory yields and with high diastereoselectivity. In addition, the base-promoted dimerization of MBH carbonates of isatin afforded the ethylene-bridged bis(3-methylene)oxindole derivatives with nearly 4:1 diastereomeric ratios. The relative configurations of the various polycyclic compounds were clearly elucidated by determination of several single crystal

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31

Hassanzadeh, Farshid, Seyed Hossein Hejazi, Elham Jafari, Atefeh Mohammadi fard, and Hojjat Sadeghi-aliabadi. "Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities." Research in Pharmaceutical Sciences 19, no. 2 (2024): 238–50. http://dx.doi.org/10.4103/rps.rps_244_22.

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Background and purpose: Isatin derivatives have excited attention due to their biological attractions, especially, anticancer properties. Isatin analogs such as semaxanib and sunitinib were exposed to tyrosine kinase inhibitory properties. N-substituted isatins were reported to show cytotoxic activity. On the other, the extension of impressive and cost-effective agents against leishmaniasis is necessary in third-world countries. The capability of isatin derivatives to create novel anticancer and anti-leishmanial compounds has been identified in medicinal chemistry research. The current study a

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32

Hudák, Alexander, Adam Košturiak, Alexander Hanudeľ, and Pavol Meľuch. "Cathodic Reduction of Isatin-3-oxime." Collection of Czechoslovak Chemical Communications 58, no. 8 (1993): 1803–12. http://dx.doi.org/10.1135/cccc19931803.

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The molecule of isatin-3-oxime was studied polarografically over the region of pH 1 to 13. Cathodic reduction within the region of pH 1 to 10.5 gives rise to a single four-electron polarographic wave due to the reduction of the oxime group, whereas two polarographic waves are observed at pH 10.5 to 13: one is due to the reduction of the isatin-3-oxime anion, the other, more negative wave is associated with the reduction of the oxime group in the α-oxime isatinic acid anion, which is the product of hydrolytic cleavage of the isatin ring in the basic pH region. The experimental results give evid

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33

Pradana, Radiktya Surya, and Muhammad Salman Fareza. "Isatin come on the stage of CDK4/6 inhibitor." Pharmacy Reports 2, no. 2 (2022): 12. http://dx.doi.org/10.51511/pr.12.

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Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved the prognosis for patients with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer, including those with metastatic or advanced breast cancer (mBC/ABC). Recent research has focused on developing CDK4/6 inhibitors with diverse structural frameworks, including isatin-based compounds. Isatin and its derivatives have shown promise in inhibiting CDK4/6, with potential efficacy against breast cancer cell lines. Studies have also indicated that isatinyl-2-aminobenzoylhydra

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34

Mustafa Mahmood Mukhlif and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, and Preliminary Antimicrobial Evaluation of New Schiff Bases and Mannich Bases of Isatin." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Suppl. (2023): 156–63. http://dx.doi.org/10.31351/vol32isssuppl.pp156-163.

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Till now, isatin derivatives have received a lot of interest in organic and medicinal chemistry due to their significant biological and pharmacological activities. Schiff’s and Mannich bases of isatins are an effective group of heterocyclic derivatives that play a significant role in medicinal chemistry as antimicrobial agents. In light of these facts, new Schiff bases and Mannich bases of isatin were synthesized. The monomer Mannich bases; 3(a-e) have been synthesized by reacting isatin with different secondary amines, piperidine, morpholine, and pyrrolidine, dimethylamine, diphenylamine, sep

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Abdulkadir, Maadh Q., Abdulhafeedh H. Abdulwahab, and May M. J. Al-Mudhafar. "Synthesis and Evaluating the Antimicrobial Activities of Various Adducts Prepared from Isatins and Proline." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (2022): 682–87. http://dx.doi.org/10.25258/ijddt.12.2.38.

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characteristic tissues and cells, exerting their pharmacological aspects and alleviating a lot of diseased processes. Accordingly, this research is about introducing some isatins to be nucleophilically attacked at C3 forming products of azomethine ylide functionality. These iminium compounds were made by allowing certain isatins to be reacted with the secondary amino acid, proline, at acetic acid and methanol medium and then collected after purification to be identified with total Leukocyte count (TLC) and melting point. The structural characterization was performed by fourier-transform infrar

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Hala Ayad Mohamed Rasheed and Suaad M. H. Al-Majidi. "Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 33, no. 2 (2024): 36–48. http://dx.doi.org/10.31351/vol33iss2pp36-48.

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Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid. 1HNMR and 13CNMR nuclear magnetic resonance spectroscopies, as well as Fourier-transform infrared spectroscopy, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin are of interest to us due to their potential antioxidant and anticancer properties. The MTT assay ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium B

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Thakur, Pramod B., та Harshadas M. Meshram. "An Exploration of Organocatalyst 1,4-Diazabicyclo[2.2.2]octane in the Direct Regioselective and Chemoselective γ-Addition of β-Keto Amide on Isatin to Afford Structurally Diverse Molecular Frameworks". Australian Journal of Chemistry 68, № 3 (2015): 453. http://dx.doi.org/10.1071/ch14239.

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An efficient protocol promoted by 1,4‐diazabicyclo[2.2.2]octane is described for the regioselective and chemoselective γ-addition of β-keto amides on isatins to afford γ-(3-hydroxy-2-oxindole)-β-keto amide structural framework under metal-free conditions. The developed method is mild, generates high yields, and is applicable for a variety of isatin electrophiles as well as β-keto amides. Moreover, the procedure is very handy and environmentally benign in nature, and provides direct access for the synthesis of diverse functionalized 3-β-keto amide-substituted 3-hydroxy-2-oxindole structural sca

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Rao, Narra Laxmana, Kolakuluri Chaguruswamy, Mohan Lakshmi Punna Rao Alapati, and Vemulapalli Vandana. "Non-metallic catalyzed synthesis of substituted [3,3':3',3''-terindolin]-2'-ones and 3,3'- (phenylmethylene)bis(1H-indoles)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 209. https://doi.org/10.59467/ijhc.2025.35.209.

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Camphor sulfonic acid (CSA) was found to be a low-cost, readily available, and efficient non-metallic catalyst for the electrophilic substitution reaction of a substituted indole with various isatins and aryl aldehydes in 30% MeCN-H2O solvent to afford the corresponding [3,3':3',3''-terindolin]-2'-one and 3,3'-(phenylmethylene)bis(1H-indole) with higher yields at room temperature. This new procedure has remarkable features, such as experimental simplicity, less expensive, high conversions, good to excellent yields, shorter reaction times, and simple work-up procedures.. KEYWORDS :Camphor sulfo

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Black, DS, N. Chaichit, BM Gatehouse, and GI Moss. "Metal Template Reactions. XXV. N-Acyl Isatin Precursors for the Synthesis of Malonamido Macrocyclic Metal Complexes." Australian Journal of Chemistry 40, no. 10 (1987): 1745. http://dx.doi.org/10.1071/ch9871745.

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Reaction of sodium isatide with dimethylmalonyl dichloride yielded the oxazinoindole (6) rather than the expected product (4). The glyoxylamide (8), which served as a precursor to the macrocyclic complex (15), was therefore prepared by a sequence involving compounds (9), (10) and (7). Such a route makes use of the reactivity of N-acyl isatins and the protecting capacity of the benzyloxycarbonyl group. The structure of compound (6) was established by X-ray crystallography.

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Bjerregaard-Andersen, Kaare, Theis Sommer, Jan Jensen, Bjarne Jochimsen, Michael Etzerodt, and Jens Preben Morth. "A proton wire water channel revealed in the crystal structure of isatin hydrolase." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1792. http://dx.doi.org/10.1107/s2053273314082084.

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Two high resolution crystal structures of isatin hydrolase (IH) from the Baltic seabed bacteria Labrenzia aggregata are presented. The crystals structure capture both the apo and the product state. This hydrolase present a new fold and the first metal-dependent hydrolase with this fold to be functionally characterized[1]. The Isatin hydrolase catalyze the reaction that convert isatin to isatinate and belongs to a novel family of metalloenzymes that include bacterial kynurenine formamidase (KynB) also recently published, however hoste a binclear zink site in the active site[2] as compared to a

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Thakur, Pramod B., Jagdeesh B. Nanubolu, and Harshadas M. Meshram. "DABCO Promoted Regioselective Synthesis of New Diversely Functionalized 3-Hydroxy-2-Oxindole Scaffolds." Australian Journal of Chemistry 67, no. 5 (2014): 768. http://dx.doi.org/10.1071/ch13580.

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An efficient and highly regioselective γ-addition of β-keto sulfones on isatins has been achieved in the presence of a catalytic amount of 1,4-diazabicyclo[2.2.2]octane (DABCO) to afford a γ-(3-hydroxy-2-oxindole)-β-keto sulfone structural framework. The scope of the method is tested by screening a series of isatin electrophiles as well as β-keto sulfones. The described method was found to be very handy and provides straightforward access for the diversely functionalized 3-β-keto sulfone substituted-3-hydroxy-2-oxindole structural scaffolds in very good yields from readily available starting m

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Antol, Ivana, Petar Štrbac, Yasujiro Murata, and Davor Margetić. "Theoretical Study of the Mechanism of the Formation of Azomethine Ylide from Isatine and Sarcosine and Its Reactivity in 1,3-Dipolar Cycloaddition Reaction with 7-Oxabenzonorbornadiene." International Journal of Molecular Sciences 25, no. 12 (2024): 6524. http://dx.doi.org/10.3390/ijms25126524.

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The reaction mechanism of tthe formation of azomethine ylides from isatins and sarcosine is addressed in the literature in a general manner. This computational study aims to explore the mechanistic steps for this reaction in detail and to assess the reactivity of formed ylide in a 1,3-dipolar cycloaddition reaction with 7-oxabenzonorbornadiene. For this purpose, density functional theory (DFT) calculations at the M06-2X(SMD,EtOH)/6-31G(d,p) level were employed. The results indicate that CO2 elimination is the rate-determining step, the activation barrier for 1,3-dipolar cycloaddition is lower,

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Tokushige, Keisuke, Shota Asai, and Takumi Abe. "Molecular Iodine-Catalyzed Synthesis of 3,3-Disubstituted Isatins: Total Synthesis of Indole Alkaloid, 3,3-Dimethoxy-2-oxindole." Chemistry 7, no. 2 (2025): 43. https://doi.org/10.3390/chemistry7020043.

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3,3-Dialkoxy-2-oxindoles are prevalent in natural products and exhibit unique biological activities. Among them, acyclic alkoxy analogues show instability in acidic conditions, making access to acyclic isatin ketals highly challenging. Conventional methods for the synthesis of 3,3-dialkoxy-2-oxindoles usually require strongly acidic and harsh reaction conditions, resulting in a low overall efficiency. Herein, we report on an acid- and metal-free protocol for the synthesis of 3,3-dialkoxy-2-oxindoles from isatins through an iodine-catalyzed ketalization. This photochemical protocol does not req

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Alpana, K. Gupta, and S. Sindal Rajendra. "Cyclic voltammetric behaviour of isatin on HMDE in different conditions." Journal of Indian Chemical Society Vol. 84, Jul 2007 (2007): 688–92. https://doi.org/10.5281/zenodo.5824366.

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Department of Chemistry, Jai Narayan Vyas University, Jodhpur-342 001, Rajasthan, India <em>E-mail </em>: alpanakr@rediffmail.com Ma<em>nuscript received 26 December 2006, revised 30 March 2007, accepted 25 April 2007</em> The electrochemical behaviour of isatin on the Hanging Mercury Drop Electrode (HMDE) in aqueous KNO<sub>3, </sub>1<em>N</em> H<sub>2</sub>SO<sub>4</sub> and acetate buffer of varying pH was investigated using Cyclic Voltammetry (CV) technique. Influence of pH, scan rate and concentration of isatin was studied on the voltammetric response in different supporting electrol

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Jamali, Muhammad Fahad, Ekta Gupta, Anuj Kumar, Ruchir Kant, and Kishor Mohanan. "Ag‐Catalyzed Trifluoromethylative Ring Expansion of Isatins and Isatin Ketimines with Trifluorodiazoethane." Chemistry – An Asian Journal 15, no. 6 (2020): 757–61. http://dx.doi.org/10.1002/asia.201901799.

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Hossain, Mohammad Mamun, Sukanta Kumar Shaha, and Foysal Aziz. "Antioxidant potential study of some synthesized N-heterocycles." Bangladesh Medical Research Council Bulletin 35, no. 2 (2009): 49–52. http://dx.doi.org/10.3329/bmrcb.v35i2.2564.

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Nitrogen containing heterocyclic compounds such as oxindoles especially isatins and their derivatives have excellent biological properties such as anti-inflammatory, antimicrobial, anticancer activity. In addition, this is first time ever we would like to report the antioxidant properties of the said class of compounds. To determine such an important bioactivity a number of halogenated oxindoles 1-3, their diaza-biphenyl derivatives (4-6), ring extended biphenyl (7) and bis-amide (8) were synthesized by classical heating method. The antioxidant activity of all the synthesized compounds was scr

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Alpana, K. Gupta, and S. Sindal Rajendra. "Comparative voltammetric behaviour of isatin and some of its Schiff bases at a solid electrode." Journal of Indian Chemical Society Vol. 85, Apr 2008 (2008): 417–24. https://doi.org/10.5281/zenodo.5814956.

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Department of Chemistry, Jai Narayan Vyas University, Jodhpur-342 001, Rajasthan, India <em>E-mail : </em>alpanakr@rediffmail.com <em>Manuscript received 20 September 2007, revised 17 December 2007, accepted 17 December 2007</em> The electrochemical behaviour of isatin (1) and its Schiff base, 3-arylimino-2<em>H</em>-indol-2-ones (2a-g), has been investigated and compared using cyclic (CV) and differential pulse voltammetry (DPV) techniques at glassy carbon electrode (GCE) in different solvent systems. CV of isatin (1) solution in DMF in 0.1 <em>M</em> LiCI showed two irreversible reduction st

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Zaghari, Zahra, та Javad Azizian. "Synthesis of Novel α-amidino Carboxylic Acids and their Use as H-Bond Catalysts in Strecker Reaction". Combinatorial Chemistry & High Throughput Screening 21, № 8 (2018): 609–14. http://dx.doi.org/10.2174/1386207321666181114110039.

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Aim and Objective: A wide variety of synthesized amidine derivatives are bioactive compounds. They show a vast range of medical properties. Therefore, a simple route for synthesis of novel class of amidine derivatives called amidino carboxylic acids and their use as catalysts in Strecker reaction has been reported in the current work. The stability, local charge density and hydrogen bond parameters were calculated for eight derivatives with different substituents. Materials and Methods: In order to synthesize these amidino carboxylic acids, we initially prepared Knovenogel condensation product

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Al-Majid, Abdullah Mohammed, M. Ali, Mohammad Shahidul Islam, et al. "Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents." Molecules 26, no. 20 (2021): 6305. http://dx.doi.org/10.3390/molecules26206305.

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A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c, 5-nitroisatin, 3d, 5-methoxyisatin, 3e, and 5-methylisatin, 3f, and (2S)-octahydro-1H-indole-2-carboxylic acid 2, in situ azomethine ylides reacted with the cyclohexanone based-chalcone 1a–f to afford the target di-spirooxindole compounds 4a–n. This one-pot method provided diverse structurally complex molecules, with biologically relevant spiro

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Dowlatabadi, Reza, Ali Khalaj, Sima Rahimian, et al. "Impact of Substituents on the Isatin Ring on the Reaction Between Isatins with Ortho-Phenylenediamine." Synthetic Communications 41, no. 11 (2011): 1650–58. http://dx.doi.org/10.1080/00397911.2010.491596.

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