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Relevant bibliographies by topics / Isoquinoline derivatives

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Academic literature on the topic 'Isoquinoline derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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Journal articles on the topic "Isoquinoline derivatives"

1

Yang, Chunmei, Guoqing Zhang, Senling Tang, Yang Pan, Huawu Shao, and Wei Jiao. "Dess–Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide." Molecules 28, no. 3 (2023): 923. http://dx.doi.org/10.3390/molecules28030923.

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Dess–Martin periodinane (DMP) is a broadly applicable oxidant in chemical synthesis. In this work, an efficient and convenient synthesis of N-substituted isoquinolinone derivatives mediated by DMP was achieved through the oxidative coupling reaction of functionalized isoquinoline with readily available benzyl bromide, which is a metal-free, mild, and practical method for synthesizing isoquinoline-1,3-dione or isoquinoline-1,3,4-trione derivatives in excellent yields. The H2O18-labeling experiment was performed to gain insight into the possible mechanism for this reaction.

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Wu, Wei, Yan Wang, Jing Guo та ін. "Asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)phosphonate and diazoacetate catalyzed by chiral Brønsted acids". Chemical Communications 56, № 76 (2020): 11235–38. http://dx.doi.org/10.1039/d0cc03201h.

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Yang, Xiaobo, Jiyang Jie, Haoyi Li та Meihui Piao. "Ir(iii)-catalyzed synthesis of isoquinolines from benzimidates and α-diazocarbonyl compounds". RSC Advances 6, № 62 (2016): 57371–74. http://dx.doi.org/10.1039/c6ra10045g.

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We report herein a tandem Ir(iii)-catalyzed C–H activation and annulation reactions for the synthesis of isoquinolines. This novel method affords an alternative strategy for the construction of diverse and useful isoquinoline derivatives.

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Balewski, Łukasz, Franciszek Sączewski, Maria Gdaniec, Anita Kornicka, Karolina Cicha, and Aleksandra Jalińska. "Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives." Molecules 24, no. 22 (2019): 4070. http://dx.doi.org/10.3390/molecules24224070.

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Isoquinoline derivatives have attracted great interest for their wide biological and fluorescent properties. In the current study, we focused on the synthesis of a series of novel isoquinoline derivatives substituted at position 3 of the heteroaromatic ring. Compounds were obtained in a Goldberg–Ullmann-type coupling reaction with appropriate amides in the presence of copper(I) iodide, N,N-dimethylethylenediamine (DMEDA), and potassium carbonate. The structures of novel isoquinolines were confirmed by IR, NMR, and elemental analysis, as well as X-ray crystallography. In the course of our resea

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Clark, Robin D., Jahangir, and James A. Langston. "Heteroatom-directed lateral lithiation: synthesis of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines." Canadian Journal of Chemistry 72, no. 1 (1994): 23–30. http://dx.doi.org/10.1139/v94-005.

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Methodology for the preparation of isoquinoline derivatives from N-(tert-butoxycarbonyl)-2-methylbenzylamines (1) was developed. Conversion of 1 to the dilithio species followed by condensation with DMF afforded Boc-3-hydroxy-1,2,3,4-tetrahydroisoquinolines 3, which could be dehydrated to 1,2-dihydroisoquinolines 4. Hydrogenation of dihydro compounds 4 afforded the corresponding tetrahydroisoquinolines 5. Treatment of the dilithio species from 1 with N-methoxy-N-methylamides afforded ketones 14, which were converted to 3-substituted dihydro-isoquinoline 15, tetrahydroisoquinolines (16, 17), or

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Sloop, Joseph C. "Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress." Journal of Chemistry 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/2860123.

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Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the inco

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Bremner, JB, CL Raston, GL Rowbottom, AH White, and KN Winzenberg. "A Ring Destruction Approach to Some Benzo-Fused Medium-Sized Heterocycles by Means of Cyanogen-Bromide Under Solvolytic Conditions - X-Ray Structure of a '1h-2,6-Benzoxazecine-6-Carbonitrile and a '2h-3,6-Benzoxazecine-6-Carbonitrile Derivative." Australian Journal of Chemistry 39, no. 6 (1986): 893. http://dx.doi.org/10.1071/ch9860893.

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Reaction of the reduced pyrrolo [2,1-a] isoquinoline amine (1a) with cyanogen bromide in the presence of methanol gave the medium-ring cyanamide derivative 7,9,10-trimethoxy-2,3,4,5,6,7-hexahydro-1H-3- benzazonine-3-carbonitrile (2a). Analogous products were also obtained from reaction of the reduced 5H-oxazolo[2,3-a] isoquinoline , 2H- benzo [a] quinolizine , 2H,6H-[1,3] oxazino [2,3-a] isoquinoline and [1,4] oxazino [3,4-a] isoquinoline derivatives (1b-e), whereas the reduced 3H-oxazolo[4,3-a] isoquinoline and 5H-oxazolo[2,3-a] isoquinoline derivatives (1f) and (8) gave 1-(2,4-dioxapentyl)-6

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8

Gouda, Moustafa A., Hanan I. Althagbi, Nourah A. Al Zahrani, Ameen A. Abu-Hashem, Tahah A. Ameen, and Alshymaa Z. Al-Mokadem. "Synthesis, reactions and applications of pyrimido[2,1-a]isoquinolines derived from 1, 2-difunctionalized pyrimidine derivatives (Part V)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 1. https://doi.org/10.59467/ijhc.2025.35.1.

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Pyrimido[2,1-a]isoquinolines (Py-[2,1-a]isoQs) are a class of heterocyclic compounds that have gained significant attention in the fields of organic chemistry, medicinal chemistry, and materials science. (Py-[2,1-a]isoQs) consist of a pyrimidine ring fused to an isoquinoline ring. This unique structure imparts distinct electronic and steric properties, making them attractive for various applications. They have been explored as potential therapeutic agents for treating cancer, and infectious diseases; their planar structure and conjugation make them suitable for applications in organic electron

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Pearson, Stuart, Shaun Fillery, Kristin Goldberg, et al. "Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions." Synthesis 50, no. 24 (2018): 4963–81. http://dx.doi.org/10.1055/s-0037-1610223.

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Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

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Hammouda, M., A. S. El-Ahl, Y. M. El-Toukhee, and M. A. Metwally. "Reactions of Ketonic Mannich Bases with Malononitrile and Malononitrile dimer." Journal of Chemical Research 2002, no. 2 (2002): 89–94. http://dx.doi.org/10.3184/030823402103171258.

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The reaction of malononitrile with the tertiary Mannich base hydrochloride derived from acetophenone and some related compounds 1, 3, 5 and 7, in piperidine at 50°C afforded the pyrido[1,2-a]pyrimidine derivatives 2, tetrahydronaphthalene derivative 4 substituted quinolines 6 and benzopyran derivatives 8. While the condensation of malononitrile dimer with acetophenone, cyclohexanone and/ or α-tetralone Mannich bases hydrochloride 1, 3 and 9 gave the pyridine, isoquinoline and benzo[f]isoquinoline derivatives 10–12 in moderate to good yield.

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Dissertations / Theses on the topic "Isoquinoline derivatives"

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McNaught, Kevin St Patrick. "The neurotoxic potential of isoquinoline derivatives structurally related to the Parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321681.

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Charpentier, Langlois Patricia. "Activation d'une réaction entre un acide et une amine par reconnaissance moléculaire. Synthèse d'un récepteur d'amine." Rouen, 1995. http://www.theses.fr/1995ROUES027.

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Notre objectif a été de définir un récepteur hétérocyclique susceptible de faciliter, de manière générale, la réaction entre un acide carboxylique et une amine afin de conduire à un amide. La première partie de ce travail a consisté en l'examen de diverses stratégies d'approche de la partie tricyclique du récepteur. Nous nous sommes notamment intéressés à des dérivés de la tétrahydroisoquinoléine. A cette occasion, nous avons été amenés à apporter une contribution intéressante à la chimie de ce type de dérivés. Dans une seconde partie, nous nous sommes attachés à synthétiser la partie simplifi

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3

Berk, Mujde. "Development Of New Synthetic Methodologies For Isoquinolone And Isoindolinone Derivatives." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612145/index.pdf.

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ABSTRACT DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES FOR ISOQUINOLONE AND ISOINDOLINONE DERIVATIVES M&uuml<br>jde, Berk M.Sc., Department of Chemistry Supervisor: Prof. Dr. Metin Balci July 2010, 146 pages Due to the wide range of physiological activities, heterocycles containing nitrogen and oxygen have always attracted the interest of chemists. The objective of this research is to develop new synthetic routes to the synthesis of isoquinolone and isoindolinone derivatives starting from 2-(2-carboxyethyl)benzoic acid and homophthalic acid, respectively. The half ester produced from 2-(2-carboxy

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Liu, Shih-I., and 劉士毅. "Synthesis of Tetrahydroisoquinoline Derivatives Molecular Library and Gold-Assisted Synthesis of Isoquinolino[1,2-a]isoquinoline Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/22843163564865086291.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>105<br>Use Pictet-Spengler reaction to synthesize tetrahydroisoquinoline then react with isocyanate, isothiocyanate, isoselenocyanate via [3 + 2] cycloaddition to obtain imidazo[1,5-b]isoquinoline, or react with chloroacetyl chloride then follow by primary amine to obtain pyraz[1,2-b]isoquinoline, and build up the molecular libraries. Gold-Assisted one-pot two-step synthesis of isoquinolino[1,2-a]isoquinoline. First step undergo Pictet-Spengler reaction, then second step follow by gold catalyze 6-endo-dig cyclization to give the isoquinolino[1,2-a]isoquinoline.

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Yu-Chen, Wu, and 吳育真. "Nickel-Catalyzed Synthesis of Isoquinoline Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/91992194016068934547.

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6

Yang, Huei-Ting, and 楊惠婷. "Synthesis of Benzofuran, Fused Isoindolinone and Isoquinoline Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/28459742252781734765.

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碩士<br>國立臺灣師範大學<br>化學系<br>104<br>The content of the thesis is divided into two parts. The first part focuses on the chemistry of the nitro alkenes and its application in the synthesis of naphthofuran derivatives. The methodology is based on one-pot base mediated tandem reaction of β-nitrostyrene derivatives and 2-naphthol, 1,4-Michael addition and intramolecular cyclization. A wide variety of naphthofuran derivatives were synthesized in relatively good yields under mild condition. The second part describes about the synthesis of fused isoindolinone and isoquinoline derivatives in two step proc

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Chen, Chih-Jen, and 陳致壬. "Synthesis of Isoquinoline via Aerobic Oxidation of Indene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/h3wbqg.

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碩士<br>中原大學<br>化學研究所<br>102<br>The purpose of this study was to investigate the synthesis of isoquinolines, from indene derivatives with urea and oxygen via one-pot reaction. It was found that the best yield was obtained by using of a 3:2 mixture of 1,4-dioxane and toluene as solvent. Transition metal catalyst was not needed in this reaction. Previausly reported syntheses of isoquinoline derivatives were carried out in acidic conditions or needed a transition metal as catalyst in the reaction. In this research, out method is metal-free and the reaction condition is relativily mild.

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Chen, Ying-Hui, and 陳盈惠. "Novel Synthesis of 1-Phenyl-4-hydroxy-isoquinoline Derivatives." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/z8dggr.

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碩士<br>中國醫藥大學<br>藥學系碩士班<br>101<br>For many years isoquinolines have been an interesting structural class of compounds, and their derivatives, 4-hydroxyisoquinolines, exhibited a range of physiological activities. Due to its wide applications in the field of pharmaceuticals, this type of compounds has attracted our attention. We developed an efficient method to synthesize 4-hydroxy-1-phenylisoquinolines from methyl N-(diphenylmethylene)glycinates via the loss of methanol followed by intramolecular electronic cyclization. A series of 3-substituted 4-hydroxy-1-phenylisoquinolines was synthesized,

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Kuo, Reen-Yen, and 郭荏耘. "Chemical and Biological Studies on the Constituents of Rollinia mucosa Baill. and the Synthesis of Isoquinoline Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/84767661870035281015.

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博士<br>高雄醫學大學<br>藥學研究所<br>91<br>In the continuing research of Formosan Annonaceous plants, the methanolic extracts of leaves and stems of Rollinia mucosa Baill. were investigated for their chemical constituents and biological activities, respectively. Fifty-one compounds were isolated including twenty-eight alkaloids, three flavonoids, six lignans, five steroids, one acetogenin, one pyrrole, and seven benzenoids. Among these compounds, eight of them including (-)-artabonatine A (AP-10), romucosine A-D (AP-13~16), promucosine (PA-2), rollipyrrole (PY-1) and romucosine I (PH-1) are isolated as ne

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Wu, Jian-Lin, and 吳建霖. "Quinoline and Isoquinoline Derivatives as Red and Green Phosphorescent Iridium Complexes and Their Application in Organic Electroluminescent Devices." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/92436570960687309743.

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博士<br>國立清華大學<br>化學系<br>97<br>Abstract The thesis includes three parts that focuses on synthesizing various red and green phosphorescent iridium complexes. In the first part, the alkenylquinoline and alkenylisoquinoline derivatives were prepared by two different procedures. The iridium(III) complex cyclometalated with alkenylquinoline or alkenylisoquinoline ligangs as red-light emitters for OLED application. Those complexes show deep red phosphorescent emissions. The optimed device structure is NPB(10nm)/TCTA(20nm)/Dopants(5%):CBP(or o-CzOXD)(30nm)/BCP (10nm)/Alq(50nm)/LiF(1nm)/Al(100nm). When

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Books on the topic "Isoquinoline derivatives"

1

Ring-opening and nitrene insertion reactions in isoquinoline derivatives. University of Northumbria, 1993.

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Stanley, Alan Leslie. Ring-opening and nitrene insertion reactions in isoquinoline derivatives. 1993.

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Book chapters on the topic "Isoquinoline derivatives"

1

Niwa, Toshimitsu, Mitsuharu Kajita, and Toshiharu Nagatsu. "Isoquinoline Derivatives." In Pharmacology of Endogenous Neurotoxins. Birkhäuser Boston, 1998. http://dx.doi.org/10.1007/978-1-4612-2000-8_1.

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Neusch, Clemens, and Andreas Moser. "Monoamine Oxidase: Interaction with Isoquinoline Derivatives." In Pharmacology of Endogenous Neurotoxins. Birkhäuser Boston, 1998. http://dx.doi.org/10.1007/978-1-4612-2000-8_11.

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Popp, F. D., and F. F. Duarte. "Isoquinoline Carboxylic Acids and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187128.ch2.

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Nair, M. D., and M. S. Premila. "Halogenated and Metallated Isoquinolines and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187128.ch1.

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Dyke, S. F., and R. G. Kinsman. "Properties and Reactions of Isoquinolines and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187111.ch1.

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Bunting, J. W. "Isoquinolines Containing Oxidized Nitrogen Functions and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187128.ch4.

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Mathison, I. W., and W. E. Solomons. "Isoquinolines Containing Basic Functions at the Ring and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187128.ch3.

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Balasubramanian, Marudai, and Eric F. V. Scriven. "Isoquinoline and its derivatives." In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds. Elsevier, 1991. http://dx.doi.org/10.1016/b978-044453347-0.50191-9.

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Lu, S. M., and Y. G. Zhou. "Catalytic Asymmetric Hydrogenation of Isoquinoline Derivatives." In Stereoselective Synthesis 1 Stereoselective Reactions of Carbon—Carbon Double Bonds. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-201-00161.

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Margaryan, Eduard A., Asya A. Aghekyan, Zhasmina S. Arustamyan, Ruzanna E. Margaryan, Levon Sh Pirdjanov, and Hambardzum G. Khachatryan. "Synthesis of Tetrahydrobenzazepine and Isoquinoline Derivatives Possessing of Anticholinesterase Action." In 19th International Congress on Heterocyclic Chemistry. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50225-2.

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Conference papers on the topic "Isoquinoline derivatives"

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Silva, Wanderson Amaral da, Vinícius Rangel Campos, Angela Cristina P. B. dos Santos, et al. "The Ultrasound-accelerated Synthesis of New 7- Aminocarbohydrate-isoquinoline-5,8-quinone Derivatives." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0253-2.

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Cahlíková, L., A. Al Mamun, O. Janďourek, et al. "Short Lecture “Isoquinoline alkaloids and their derivatives as a new class of antimycobacterial drugs”." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758970.

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Blasko, Gy, G. Blasko, G. Sas, and Cs Szantay. "MODULATION OF THROMBIN-MEDIATED REACTIONS IN HAEMOSTASIS- BY TREQUINSIN AND ITS ANALOGUES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643432.

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A new pyrimido/6,1-a/-isoquinoline derivative ,/Ref.1 / developed by Hoechst and named Trequinsine has been reported to be a powerful inhibitor of cAMP phosphodiesterase and platelet aggregation having a potency nearly similar to prostacyclin. We synthesized Trequins-in (1), its indole derivative (4) , as well as their precursors (2 3) and subjected them to a study in order to evaluate their effects on haemostasis. Surprisingly they exhibited a modulatory effect only on reactions mediated mainly by thrombin. They inhibited platelet aggregation (ICc:q for Trequinsin: 13 + 2.5 ng/ml, for indole

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Aranzamendi Uruburu, Eider, Nuria Sotomayor, and Esther Lete. "Brønsted acid catalyzed enantioselective inter and intramolecular α-amidoalkylation reactions in the synthesis of isoquinoline derivatives." In MOL2NET 2016, International Conference on Multidisciplinary Sciences, 2nd edition. MDPI, 2016. http://dx.doi.org/10.3390/mol2net-02-h003.

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O'Donnell, Ryan M., Autumn E. Moore, Jianmin Shi, et al. "Iridium complexes containing nitro-derivatized isoquinoline ligands for photonic applications." In Organic Photonic Materials and Devices XXI, edited by Christopher E. Tabor, François Kajzar, and Toshikuni Kaino. SPIE, 2019. http://dx.doi.org/10.1117/12.2508772.

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Montagnoli, Alessia, Sonia Rainoldi, Stefania Mazzoleni, et al. "Abstract 3259: Novel isoquinolinone derivatives with dual PARP-1/PARP-3 inhibitory activity are highly active against pTEN mutated colorectal cancer and glioblastoma models.." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3259.

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