Academic literature on the topic 'Jphb'

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Journal articles on the topic "Jphb"

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Lehnart, Stephan E., and Xander H. T. Wehrens. "The role of junctophilin proteins in cellular function." Physiological Reviews 102, no. 3 (2022): 1211–61. http://dx.doi.org/10.1152/physrev.00024.2021.

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Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR). Tethering of these membrane structures results in the formation of highly organized subcellular junctions that play important signaling roles in all excitable cell types. There are four JPH isoforms, expressed primarily in muscle and neuronal cell types. Each JPH protein consists of six membrane occupation and recognition nexus (MORN) motifs, a joining region connecting these to another set of two MORN motifs, a putative alp
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Rossi, Daniela, Angela Maria Scarcella, Enea Liguori, et al. "Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers." Proceedings of the National Academy of Sciences 116, no. 31 (2019): 15716–24. http://dx.doi.org/10.1073/pnas.1820980116.

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In adult skeletal muscles, 2 junctophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum (SR) to transverse tubule (T-tubule) membranes, generating stable membrane contact sites known as triads. JPHs are anchored to the membrane of the SR by a C-terminal transmembrane domain (TMD) and bind the T-tubule membrane through their cytosolic N-terminal region, which contains 8 lipid-binding (MORN) motifs. By combining expression of GFP-JPH1 deletion mutants in skeletal muscle fibers with in vitro biochemical experiments, we investigated the molecular determinants of JPH1 recruitment at tr
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Garbino, Alejandro, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens. "Molecular evolution of the junctophilin gene family." Physiological Genomics 37, no. 3 (2009): 175–86. http://dx.doi.org/10.1152/physiolgenomics.00017.2009.

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Junctophilins (JPHs) are members of a junctional membrane complex protein family important for the physical approximation of plasmalemmal and sarcoplasmic/endoplasmic reticulum membranes. As such, JPHs facilitate signal transduction in excitable cells between plasmalemmal voltage-gated calcium channels and intracellular calcium release channels. To determine the molecular evolution of the JPH gene family, we performed a phylogenetic analysis of over 60 JPH genes from over 40 species and compared conservation across species and different isoforms. We found that JPHs are evolutionary highly cons
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Kanazawa, Yuji, Tatsuo Takahashi, Mamoru Nagano, Satoshi Koinuma, and Yasufumi Shigeyoshi. "The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice." International Journal of Molecular Sciences 25, no. 4 (2024): 2148. http://dx.doi.org/10.3390/ijms25042148.

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The pathogenesis of sarcopenia includes the dysfunction of calcium homeostasis associated with the sarcoplasmic reticulum; however, the localization in sarcoplasmic reticulum-related factors and differences by myofiber type remain unclear. Here, we investigated the effects of aging on sarcoplasmic reticulum-related factors in the soleus (slow-twitch) and gastrocnemius (fast-twitch) muscles of 3- and 24-month-old male C57BL/6J mice. There were no notable differences in the skeletal muscle weight of these 3- and 24-month-old mice. The expression of Atp2a1, Atp2a2, Sln, and Pln increased with age
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Muangrod, Pratchaya, Wiriya Charoenchokpanich, Vilai Rungsardthong, et al. "Effect of pepsin hydrolysis on antioxidant activity of jellyfish protein hydrolysate." E3S Web of Conferences 302 (2021): 02010. http://dx.doi.org/10.1051/e3sconf/202130202010.

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Edible jellyfish have been consumed as food for more than a century with offering high protein and crunchy texture. The pepsin hydrolysis of jellyfish protein yields jellyfish protein hydrolysate (ep-JPH), reported for potential bioactivities such as antioxidant activity or antihypertensive activities. Due to the substantial number of by-products generated from jellyfish processing, the by-products were then selected as a raw material of JPH production. This research aimed to evaluate the effect of the hydrolysis time of pepsin on the antioxidant activity of ep-JPH. The dried desalted jellyfis
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Gross, Polina, Jaslyn Johnson, Carlos M. Romero, et al. "Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca 2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca 2+ Dynamics." Circulation Research 128, no. 1 (2021): 92–114. http://dx.doi.org/10.1161/circresaha.119.315715.

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Rationale: Ca 2+ -induced Ca 2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are redistributed from the T-tubules to disrupt CICR. The molecular mechanism responsible for LTCCs recruitment to and from the T-tubules is not well known. JPH (junctophilin) 2 enables close
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Feng, Yu, Yan Chen, Binrui Yang, et al. "Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat." BioMed Research International 2019 (July 1, 2019): 1–12. http://dx.doi.org/10.1155/2019/7465272.

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In parallel with the prevalence metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in most countries. It features a constellation of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma. There are no approved drugs for effective management of NAFLD and NASH. Jianpi Huoxue formula (JPHX) mainly consists of Atractylodes macrocephal(Baizhu), Salvia miltiorrhiza (Danshen), Rasux Paeonia Alba (Baishao), Rhizoma Alismatis (Zexie), and Fructus Schisandrae Chinensis (Wuweizi), which may
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Pritchard, Harry A. T., Caoimhin S. Griffin, Evan Yamasaki, et al. "Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility." Proceedings of the National Academy of Sciences 116, no. 43 (2019): 21874–81. http://dx.doi.org/10.1073/pnas.1911304116.

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Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in many types of cells, as typified by junctophilin-2 (JPH2), which is necessary for the formation of the cardiac dyad. Here, we report that JPH2 is the most abundant junctophilin isotype in native smooth muscle cells (SMCs) isolated from cerebral arteries and that acute knockdown diminishes the area of sites of interaction between the SR and plasma membrane. Superresolution microscopy revealed nanometer-scale colocalization of JPH2 clusters with type 2 ryanodine recepto
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Huang, Yajing, Cheng Zhou, Huihong Wen, et al. "Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the RASSF1A Gene." Integrative Cancer Therapies 19 (January 2020): 153473541990080. http://dx.doi.org/10.1177/1534735419900804.

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The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. In this article, we employed an orthotopic transplantation model in nude mice to explore whether JPHY could inhibit the development of HCC by regulating miR-602, which targets the Ras association domain-containing protein 1A (RASSF1A) pathway. HCC SMMC-7721 cells were treated with JPHY to test whether the RASSF1A gene as mediated by miR-602 affected the proliferation and apoptosis of tumor cells. We
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Siham, Muhammed Ali. "Evaluating the functional and genomic analysis of pathogenic junctophilin-2 variants and their association with the pathogenesis of cardiomyopathy to understand their molecular impact on cardiac calcium homeostasis and disease phenotypes." Annals of Pediatric Cardiology 17, no. 6 (2024): 401–7. https://doi.org/10.4103/apc.apc_173_24.

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ABSTRACT The growing body of evidence suggests that junctophilin-2 (JPH2) variants hold significant potential for diagnostic and therapeutic interventions, particularly within the framework of personalized medicine and genetic screening across diverse populations. Mutations in JPH2 have been associated with a range of clinical phenotypes including early-onset heart failure and cardiomyopathies, a diverse group of diseases affecting heart muscle structure and function that contribute to heart failure and sudden cardiac death. While traditional understanding has centered on sarcomeric gene mutat
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Dissertations / Theses on the topic "Jphb"

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Caterina, Amato. "Evaluation of JPH1 protein interactors by the “Proximity-dependent Labelling with BioID2” approach." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1106621.

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In skeletal muscle, several proteins are organized at typical membrane contact sites (MCSs) between the plasma membrane (PM) and the sarcoplasmic reticulum (SR), known as triads. Interactions between proteins at triads are essential to organize the macromolecular complex that mediates the mechanism of excitation-contraction coupling (E-C coupling), which links nerve-induced depolarization with calcium release from sarcoplasmic reticulum, resulting in activation of contraction. In order to identify novel interactions among triadic proteins, the enzyme-mediated labelling technique Proximity-de
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Börjesson, Sara, and Kim Fogelström. "Framtagning avproduktivitetshöjande åtgärder på produktionslina Scania : Utvärdering samt rekommendationer baseratpå produktivitetsmått och nulägesanalys." Thesis, KTH, Industriell produktion, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278154.

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Kamaxeln är en mekaniskt roterande komponent som återfinns i de flesta motorer och somtillverkas på avdelningen DM på Scania Södertälje. Scania lägger stor vikt vid produktivitet och trots goda resultat når linan ännu inte upp till de av företaget uttalade produktivitetsmålen. Arbetets syfte var att undersöka detta och föreslå produktivitetshöjande åtgärder. Centralt för arbetet var de tre måtten OPE, OEE samt JPH. De två tidigare är mycket lika varandra och är representationer av hur väl linan producerar mot sin teoretiska kapacitet medan det senare är ett mått på denna kapacitet. Vikt lades
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Roberts, Robert. "JPH2 Mutant Gene Causes Familial Hypertrophic Cardiomyopathy : A Possible Model to Unravel the Subtlety of Calcium-Regulated Contractility." Elsevier, 2017. http://hdl.handle.net/10150/623244.

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Melo, Rafael de Araújo. "Recursos linguísticos orais no telejornalismo: estratégias de audiência no texto do JPB 1ª edição." Universidade Federal da Paraíba, 2017. http://tede.biblioteca.ufpb.br:8080/handle/tede/9598.

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Submitted by Vasti Diniz (vastijpa@hotmail.com) on 2017-09-20T14:24:43Z No. of bitstreams: 1 arquivototal.pdf: 1658203 bytes, checksum: c44b0ebc3d2bab82509c5708b45bea4b (MD5)<br>Made available in DSpace on 2017-09-20T14:24:43Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1658203 bytes, checksum: c44b0ebc3d2bab82509c5708b45bea4b (MD5) Previous issue date: 2017-03-30<br>This paper discusses the update of the journalistic text Television analyzing oral language resources that are used. It started from the hypothesis that language is used not only to inform, but especially, to seek identifica
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Melo, Rostand de Albuquerque. "Telejornalismo e Cotidiano: a construção de enquadramentos sobre a vida urbana no JPB 1ª edição." Universidade Federal da Paraí­ba, 2010. http://tede.biblioteca.ufpb.br:8080/handle/tede/4495.

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Made available in DSpace on 2015-05-07T14:46:47Z (GMT). No. of bitstreams: 1 parte1.pdf: 2187075 bytes, checksum: b523a96e2976438221d433adddcc1943 (MD5) Previous issue date: 2010-04-16<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Considering the journalism while a way of specific knowledge with an own logic of perception about the everyday life, this dissertation purpose is understand the relationships between the common sense knowledge and the apprehension forms of the social reality adopted in the news production process. For so much, the theoretical perspective of Alf
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Souza, Bruna Fernandes de. "Um estudo sobre a busca pelo personagem do telejornal JPB 1ª edição da TV Cabo Branco." Universidade Federal da Paraíba, 2017. http://tede.biblioteca.ufpb.br:8080/handle/tede/9587.

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Submitted by Vasti Diniz (vastijpa@hotmail.com) on 2017-09-20T12:54:30Z No. of bitstreams: 1 arquivototal.pdf: 2540614 bytes, checksum: be63a9cf1230d85ce8c83ca97d246545 (MD5)<br>Made available in DSpace on 2017-09-20T12:54:30Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2540614 bytes, checksum: be63a9cf1230d85ce8c83ca97d246545 (MD5) Previous issue date: 2017-04-20<br>It is usual to watch on the news ordinary people, who are not experts or authorities, providing testimony, telling facts of their lives, talking about different topics. They are the characters that support and humanize the rep
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Souza, Denise Helena Delmiro de. "Tensões midiáticas (ou conflitos de mediação) entre a comunidade e a gestão pública – A agenda do Calendário JPB." Universidade Estadual da Paraíba, 2016. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2622.

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Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2016-10-13T14:44:32Z No. of bitstreams: 1 PDF - Denise Helena Delmiro de Souza.pdf: 2401179 bytes, checksum: 4a6d944273e8f164f69b4c9913d2b4b3 (MD5)<br>Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-10-17T13:33:47Z (GMT) No. of bitstreams: 1 PDF - Denise Helena Delmiro de Souza.pdf: 2401179 bytes, checksum: 4a6d944273e8f164f69b4c9913d2b4b3 (MD5)<br>Made available in DSpace on 2016-10-17T13:33:47Z (GMT). No. of bitstreams: 1 PDF - Denise Helena Delmiro de Souza.pdf: 2401179 bytes, checksum: 4a6d944273e8f164f6
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Duarte, Zuila Frutuoso David. "Processos de Reconstrução Identitária do Telejornal Local da Globo em Tempos de Concorrência e Convergência Midiática: modos de dizer, interagir e circular do JPB 1ª edição." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/7976.

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Submitted by Viviane Lima da Cunha (viviane@biblioteca.ufpb.br) on 2016-03-14T12:17:38Z No. of bitstreams: 1 arquivototal.pdf: 3587012 bytes, checksum: 60a01c4f97d7f7a2499b985683b26616 (MD5)<br>Made available in DSpace on 2016-03-14T12:17:39Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3587012 bytes, checksum: 60a01c4f97d7f7a2499b985683b26616 (MD5) Previous issue date: 2015-09-25<br>This paper aims at analyzing the renovation process of the identity of JPB 1st Edition of Globo TV. Taking into consideration that this local television news reformulates its identification strategies with
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Eikenbusch, Benjamin. "Strukturelle und funktionale Veränderungen der atrialen Kalzium-Freisetzungseinheit im Herzinsuffizienzmodell durch Junctophilin-2-Knockdown." Doctoral thesis, 2021. http://hdl.handle.net/21.11130/00-1735-0000-0005-1597-9.

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Books on the topic "Jphb"

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Garcia, Angel Muñoz. Cursus philosophicus: Antonij Jphi Suaretij de Urbina. Universidad del Zulia, 1995.

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JPH political science . Jiwan publishing , 2020.

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BOTELLA, Jean-Pierre. JPB-Art Gallery - Patrice Racois, Sculpteur. Blurb, 2018.

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lilley, p. j. New Developments in Anarchist Studies. punctum books, 2015.

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Book chapters on the topic "Jphb"

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Nozaki, Shoko, Norie Sawada, Yutaka J. Matsuoka, Ryo Shikimoto, Masaru Mimura, and Shoichiro Tsugane. "Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study." In Handbook of Prevention and Alzheimer’s Disease. IOS Press, 2024. http://dx.doi.org/10.3233/aiad230011.

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Background: The relationship between midlife dietary habits and risk of dementia remains unclear. Objective: To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life. Methods: This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45–64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA
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Conference papers on the topic "Jphb"

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"Libro de resúmenes-IVJPB." In IV Jornadas Paraguayas de Botánica. Facultad de Ciencias Exactas y Naturales. Universidad Nacional de Asunción, 2021. http://dx.doi.org/10.56152/libroresumen_ivjpb_2021.

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"Libro de Resumen de las IV Jornadas Paraguayas de Botánica." In IV Jornadas Paraguayas de Botánica. FACEN, 2021. http://dx.doi.org/10.56152/libroresumen_ivjpb_2024.

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"Libro de Resumen de las V Jornadas Paraguayas de Botánica." In V Jornadas Paraguayas de Botánica. FACEN, 2024. http://dx.doi.org/10.56152/libroresumen_vjpb_2024.

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Ugai, Tomotaka, Keitaro Matsuo, Norie Sawada, et al. "Abstract 2282: Smoking and alcohol and the risk of myelodysplastic syndrome: The JPHC study." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2282.

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Raju, Gokul, Amlan Roy, Shishir Sahu, Gowtham Raj Palavelathan, Nagireddi Jagadeesh, and Seshadri Chava. "Efficient Robot Roller Hemming Process Using Turntable over Linear Setup." In 11th SAEINDIA International Mobility Conference (SIIMC 2024). SAE International, 2024. https://doi.org/10.4271/2024-28-0164.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Hemming is an incremental joining technique used in the automotive industry, it involves bending the flange of an outer panel over an inner panel to join two sheet metal panels. Different hemming methods are available such as Press die hemming, Table-top hemming and Robot roller hemming. Robot roller hemming is superior to press hemming and tabletop hemming because of its ability to hem complex-shaped parts and is typically used in low-volume automotive production lines. For higher production volumes, such as 120 Jobs pe
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Vujnović, Larisa, and Nevena Milošević. "Serbian Journal of Public Health as an interdisciplinary resource in meeting public health challenges: A thematic analysis." In Proceedings of the International Congress Public Health - Achievements and Challenges. Institute of Public Health of Serbia "Dr Milan Jovanović Batut", 2024. http://dx.doi.org/10.5937/batutphco24200v.

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Background: Major public health challenges of the 21st century: aging population, non-communicable diseases with the associated risk factors, mental health conditions, emerging and established communicable diseases, antimicrobial resistance, environmental crises, increasingly frequent public health emergencies, infodemics, vaccine mistrust and rapid development of technology call for accessible, vetted information and knowledge exchange among scientists, policy-makers and practitioners. Peer-reviewed journals offer reliable information and may be a key resource. Serbian Journal of Public Healt
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