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Journal articles on the topic 'L1210-leukemia'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Saprykina, N. S., L. M. Borisova, M. P. Kiseleva, et al. "Antitumor activity of Ormustine against transplanted leukemia in mice." Russian Journal of Biotherapy 15, no. 2 (2016): 24–31. http://dx.doi.org/10.17650/1726-9784-2016-15-2-24-31.

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Objective: Evaluation of antitumor activity of a novel alkylnitrosoureas derivative Ormustine (an alkylnitrosocarbamoyl L-ornithine) in mouse lymphoid leukemia models. Materials and methods Antitumor activity of Ormustine has been evaluated in B6D2F1 mice with ascites form of leukemia (L1210, L1210/arenosa, L1210/citrullin and P388) and the solid (P388) form. In this study we used preparations from the alkylnitrosourea group: Ormustine, Aranoza and Lizomustine. Treatment of animals was started 24 hours after inoculation of leukemia intraperitoneally, and 48 hours after inoculation subcutaneous

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2

Miller, Merrill C., Anup Sood, Bernard F. Spielvogel, Ken Bastow, and Iris H. Hall. "Cytotoxic Action of Carboxyborane Heterocyclic Amine Adducts." Metal-Based Drugs 4, no. 4 (1997): 229–41. http://dx.doi.org/10.1155/mbd.1997.229.

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The heterocyclic carboxyborane amines were found to be potent cytotoxic agents in the murine L1210 lymphoid leukemia and human HeLa suspended carcinoma cells. These agents were observed to inhibit HeLa DNA topoisomerase II activity ~ 200 μM and L1210 topoisomerase II activity ≥ 100 μM. These agents did not cause DNA protein linked breaks themselves, but upon incubation for 14-24 hr did enhance the ability of VP-16 to cause cleavable complexes. The heterocyclic amineboranes inhibited DNA synthesis and caused DNA strand scission. They were additive with VP-16 in affording these results as well a

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3

Chekhun, V. F., A. Mokhir, S. Daum, et al. "PHARMACOLOGICAL EFFECT OF AMINOFERROCENE IN MICE WITH L1210 LEUKEMIA." Experimental Oncology 37, no. 2 (2015): 120–25. http://dx.doi.org/10.31768/2312-8852.2015.37(2):120-125.

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Aim: To study the cytostatic and some biological effects of aminoferrocene using mice with L1210 lymphoid leukemia. Materials and Methods: Experiments were performed on BDF1 male mice (DBA/2, female × C57Bl/6, male) with transplantable L1210 lymphoid leukemia. Determination of antitumor activity of Benzyl-Fc Boron (Bn), it was injected intraperitoneally 6 times daily, starting on day 2 after L1210 leukemia cell transplantation. Doses of Bn such as 26; 260 and 2600 μg/kg were used. The determination of intracellular content of cardiolipin, thiols, reactive oxygen species (ROS) and also analysis

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4

Kawiak, J., T. Skorski, A. Ciechanowicz, et al. "Cytochemical Characterization of Mouse L1210 Leukemia." Immunological Investigations 17, no. 6-7 (1988): 543–50. http://dx.doi.org/10.3109/08820138809030587.

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5

Graczyk, Julita, Grzegorz Guzowski, and Izabella Kręźel. "Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate." Pteridines 9, no. 4 (1998): 217–21. http://dx.doi.org/10.1515/pteridines.1998.9.4.217.

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Summary In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia.

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6

Vilpo, J. A., L. M. Vilpo, D. E. Szymkowski, A. O'Donovan, and R. D. Wood. "An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells." Molecular and Cellular Biology 15, no. 1 (1995): 290–97. http://dx.doi.org/10.1128/mcb.15.1.290.

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One of the most widely used antitumor drugs is cis-diamminedichloroplatinum(II) (cisplatin), and mechanisms of cisplatin resistance have been investigated in numerous model systems. Many studies have used mouse leukemia L1210/0 as a reference wild-type cell line, and cisplatin-resistant subclones have been derived from it. Increased DNA excision repair capacity is thought to play a key role in the acquired cisplatin resistance, and this has influenced development of drugs for clinical trials. We report here that the L1210/0 line is in fact severely deficient in nucleotide excision repair of da

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7

Winarno, Hendig, and Ermin Katrin W. "BENZOPHENONE GLUCOSIDE ISOLATED FROM THE ETHYL ACETATE EXTRACT OF THE BARK OF MAHKOTA DEWA [Phaleria macrocarpa (Scheff.) Boerl.] AND ITS INHIBITORY ACTIVITY ON LEUKEMIA L1210 CELL LINE." Indonesian Journal of Chemistry 9, no. 1 (2010): 142–45. http://dx.doi.org/10.22146/ijc.21576.

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Isolation and elucidation of benzophenone glucoside from ethyl acetate extract of Phaleria macrocarpa bark and its inhibitory activity test against leukemia L1210 cell line have been done. The Phaleria macrocarpa bark were macerated using n-hexane, ethyl acetate, and ethanol, respectively. The ethyl acetate extract was then chromatographed on silica gel column and gradiently eluted by n-hexane - ethyl acetate - ethanol with the composition from 20:1:0 until 0:0:1, gave eight fractions. Separation of fraction 6 using semipreparative HPLC on reverse phase column (Capcell Pak C-18 SG120, 15 mm I.

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8

Katiyar, Arpit, Mahesh Hegde, Sujeet Kumar, et al. "Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents." RSC Advances 5, no. 56 (2015): 45492–501. http://dx.doi.org/10.1039/c5ra01528f.

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New N′-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH, K562 and CEM and human cervix carcinoma, HeLa cells.

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9

Basir, Dasril, and Julinar Julinar. "THE RESTORATIVE COSMETIC CONSTITUENTS OF Fragraea fragrans FRUITS." Indonesian Journal of Chemistry 12, no. 1 (2012): 84–88. http://dx.doi.org/10.22146/ijc.21376.

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This paper describes 3-hydroxyurs-12-en-28-oic acid and its structural isomer 3-hydroxyolean-12-en-28-oic acid isolated from Fragraea fragrans fruits and their biological activities; anti-tumor, anti-inflammation, anti-microbial, and anti-fungal included their ultra violet photo-protective effect after exposed under sunlight radiation. They are useful for cosmetic ingredient. The above triterpenes are very promoting compounds for leukemia L1210 anti-tumor due to limited reports dealing with this type triterpenoid anti-tumor test. They significantly gave IC50 value of 5.78 µg/mL against leukemi

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10

Brtko, J., P. Filipčík, J. Knopp, and V. Sedláková. "Thyroid hormone responsiveness of the L1210 murine leukemia cell line." Acta Endocrinologica 126, no. 4 (1992): 374–77. http://dx.doi.org/10.1530/acta.0.1260374.

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The presence of saturable and high affinity 3,5,3′-triiodothyronine (T3) binding sites was demonstrated in LI 210 murine leukemia cell nuclei. Scatchard analysis revealed one class of receptors for T3 with Ka = 2.187 × 109l/mol and a maximum binding capacity (Bmax) of 3.96 fmol/106 cells. The effects of T3 on protein phosphorylation and growth rate of L1210 cells were investigated in a medium containing T3-depleted fetal calf serum. T3 was observed to be effective in enhancing protein phosphorylation (153.06%±5.99 sd) compared to cells grown in the absence of T3 (81.49%±13.50 sd). Moreover, in

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11

Stoika, Rostyslav, Mariya Yakymovych, Serhiy Souchelnytskyi, and Ihor Yakymovych. "Potential role of transforming growth factor beta1 in drug resistance of tumor cells." Acta Biochimica Polonica 50, no. 2 (2003): 497–508. http://dx.doi.org/10.18388/abp.2003_3702.

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Acquired drug resistance of tumor cells is frequently observed in cancer patients undergoing chemotherapy. We studied murine leukemia L1210 cells sensitive and resistant to the cytotoxic action of cisplatin and showed that cisplatin-resistant leukemia cells were also refractory to TGF beta1-dependent growth inhibition and apoptosis. Addressing the question about the mechanisms responsible for the cross-resistance to cisplatin and TGF beta1, we found that cisplatin- and TGF beta1-resistant L1210 cells possessed a decreased expression of type I TGF beta1 receptor, while the expression of type II

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12

Hromas, Robert A., James A. North, and C. Patrick Burns. "Decreased cisplatin uptake by resistant L1210 leukemia cells." Cancer Letters 36, no. 2 (1987): 197–201. http://dx.doi.org/10.1016/0304-3835(87)90091-7.

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13

Burns, C. Patrick, Bradley N. Haugstad, and James A. North. "Membrane transport of mitoxantrone by L1210 leukemia cells." Biochemical Pharmacology 36, no. 6 (1987): 857–60. http://dx.doi.org/10.1016/0006-2952(87)90176-6.

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14

Bilyy, R. O., and R. S. Stoika. "Lectinocytochemical detection of apoptotic murine leukemia L1210 cells." Cytometry 56A, no. 2 (2003): 89–95. http://dx.doi.org/10.1002/cyto.a.10089.

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15

Šereš, Mário, Lucia Pavlíková, Viera Boháčová, et al. "Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum." Cells 9, no. 4 (2020): 890. http://dx.doi.org/10.3390/cells9040890.

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P-glycoprotein (P-gp, ABCB1 member of the ABC (ATP-binding cassette) transporter family) localized in leukemia cell plasma membranes is known to reduce cell sensitivity to a large but well-defined group of chemicals known as P-gp substrates. However, we found previously that P-gp-positive sublines of L1210 murine leukemia cells (R and T) but not parental P-gp-negative parental cells (S) are resistant to the endoplasmic reticulum (ER) stressor tunicamycin (an N-glycosylation inhibitor). Here, we elucidated the mechanism of tunicamycin resistance in P-gp-positive cells. We found that tunicamycin

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16

Wang, Fei, Amy E. Warren, Cheryl R. Barnes, and Iris H. Hall. "Cytotoxicity of Poly(Phenolic)Sulfonates and Their Sodium Salts in L1210 Lymphoid Leukemia Cells." Metal-Based Drugs 5, no. 3 (1998): 147–60. http://dx.doi.org/10.1155/mbd.1998.147.

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Poly(phenolic)-sulfonates demonstrated very good cytotoxicity against the growth of tumor cell lines (L1210, Tmolt-3, HeLa-S3) and are comparable in potency with typical clinically used anticancer drugs. Four of the most active compounds, i.e. GL-2021, GL-2029, GL-2041 and GL-2063, were selected for a mode of action study in L1210 lymphoid leukemia cells at concentration of 25μM to 100μM for 60 min. The agents did not alkylate bases of ct-DNA, cause intercalation between base pairs, produce cross linking of ct-DNA strands or generate free radicals although L1210 DNA fragmentation was observed

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17

Crawford, Charles R., Carol E. Cass, James D. Young, and Judith A. Belt. "Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line." Biochemistry and Cell Biology 76, no. 5 (1998): 843–51. http://dx.doi.org/10.1139/o98-074.

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Previous studies of nucleoside transport in mammalian cells have identified two types of activities: the equilibrative nucleoside transporters and concentrative, Na+-nucleoside cotransporters. Characterization of the concentrative nucleoside transporters has been hampered by the presence in most cells and tissues of multiple transporters with overlapping permeant specificities. With the recent cloning of cDNAs encoding rat and human members of the concentrative nucleoside transporter (CNT) family, it is now possible to study the concentrative transporters in isolation by use of functional expr

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18

Chasani, Mochamad, Eva Vaulina, Ponco Iswanto, and Yayu Rahayu. "HIDRASI IKATAN RANGKAP C7-8 SENYAWA KALANON DAN UJI SITOTOKSISITASNYA TERHADAP SEL LEUKEMIA L1210." Molekul 5, no. 1 (2010): 41. http://dx.doi.org/10.20884/1.jm.2010.5.1.75.

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Calanone is anticancer compound that is isolated from species Calophyllum. The biological activity of calanone againts leukemia cell L1210 is relatively low showed by IC50 value at 59.4 μg/mL. A compound have a high biological activity if the value of IC50 under 10 μg/mL. This research aimed to obtained calanone hydrat compound which has a higher activity to inhibit leukemia L1210 cancer cell growth. Calanone hydrat compound is got through with two step reaction, first step was protonated double bond by acetic acid reagent and the second step is nucleophilic addition by water. Initial analysis

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19

Momparler, Richard L., and Louise F. Momparler. "Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2?-deoxycytidine and 3-deazauridine." Cancer Chemotherapy and Pharmacology 25, no. 1 (1989): 51–54. http://dx.doi.org/10.1007/bf00694338.

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20

Lyons, S. D., M. E. Sant, and R. I. Christopherson. "Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia." Journal of Biological Chemistry 265, no. 19 (1990): 11377–81. http://dx.doi.org/10.1016/s0021-9258(19)38603-x.

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21

Dagnino, L., L. L. Bennett, and A. R. P. Paterson. "Sodium-dependent nucleoside transport in mouse leukemia L1210 cells." Journal of Biological Chemistry 266, no. 10 (1991): 6308–11. http://dx.doi.org/10.1016/s0021-9258(18)38118-3.

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22

Sant, Melissa E., Anthony Poiner, Michael C. Harsanyi, Stephen D. Lyons, and Richard I. Christopherson. "Chromatographic analysis of purine precursors in mouse L1210 leukemia." Analytical Biochemistry 182, no. 1 (1989): 121–28. http://dx.doi.org/10.1016/0003-2697(89)90728-8.

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23

Katrin, Ermin, Siva Fauziah, Susanto Susanto, and Hendig Winarno. "Kemampuan Sitotoksik dan Profil Kromatogram Umbi Sarang Semut (Myrmecodia Pendans Merr. & Perry) Setelah Diiradiasi Gamma." Jurnal Ilmiah Aplikasi Isotop dan Radiasi 11, no. 2 (2016): 137. http://dx.doi.org/10.17146/jair.2015.11.2.2800.

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Umbi sarang semut (Myrmecodia pendans Merr. & Perry) memiliki aktivitas sitotoksik. Salah satu usaha pengawetan simplisia umbi sarang semut dilakukan dengan iradiasi gamma. Penelitian ini bertujuan untuk mempelajari pengaruh iradiasi gamma pada sitotoksisitas dan profil kromatogram fraksi aktif dari umbi sarang semut. Serbuk kering umbi sarang semut diiradiasi gamma dengan beberapa macam dosis radiasi yaitu : 0 (kontrol); 5; 7,5; 10; dan 15 kGy. Percobaan dilakukan dengan dua kali ulangan untuk masing-masing dosis. Setelah iradiasi, serbuk dimaserasi bertahap berdasarkan tingkat kepolarann

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24

Graczyk, Julita. "Effect of Folate-deficient Diet and 5-Fluorouracil Treatment In the zn VlVO Model of Mice L1210 Leukemia." Pteridines 5, no. 3 (1994): 107–10. http://dx.doi.org/10.1515/pteridines.1994.5.3.107.

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Summary The present study investigated the effect of reduced folic acid content in the organism, due to deficient diet, on the survival time of mice with L1210 leukemia, treated with fluorouracil. One of the mechanisms of the cytotoxic effect of fluorouracil is the inhibition of thymidylate synthase by binding fluorodeoxyuridylate, a 5-fluorouracil metabolite. Tetrahydrofoliane factor, for which folic acid is the substrate, takes part in this process. From the presented study it follows that the synthetic diet prepared without the addition of folic acid caused significantly lower blood serum f

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25

Šereš, Mário, Lucia Pavlíková, Zdena Sulová, and Albert Breier. "Lectin detection of cell surface saccharides remodeling induced by development of P-glycoprotein mediated multidrug resistance phenotype in L1210 leukemia cells." Acta Chimica Slovaca 7, no. 1 (2014): 52–56. http://dx.doi.org/10.2478/acs-2014-0010.

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Abstract P-glycoprotein is an ATP dependent drug efflux pump the expression of which is responsible for strong depression of cell sensitivities to large group of structurally unrelated substances in neoplastic cells. We found that the expression of this protein in mice leukemia cells L1210 is associated with massive remodeling of cell surface saccharides. This remodeling is consistent with the alteration of cellular contents of UDP-sugars, glycogen and glycoproteins when P-gp positive and P-gp negative L1210 cell variants were compared. The current paper is focused on bringing the state of art

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26

Kikuchi, Takashi, Rina Okada, Yu Harada, et al. "Cucurbitane-type Triterpenes from Citrullus Lanatus (Watermelon) Seeds." Natural Product Communications 8, no. 10 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801006.

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Two new cucurbitane-type triterpenes, 24-hydroperoxycucurbita-5,25-dien-3β-ol (1) and 25-hydroperoxycucurbita-5,23-dien-3β-ol (2), were isolated from a MeOH extract of Citrullus lanatus seeds. Compounds 1 and 2 exhibited moderate cytotoxic activities with IC50 values of 33.4–52.4 μM against HL-60 (human leukemia), P388 (murine leukemia), and L1210 (murine leukemia) cells. Compound 1 showed melanogenesis inhibitory activity (melanin content 80.0 %) with low cytotoxicity (cell viability 97.6 %) at a low concentration (10 μM).

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27

Harper, Benjamin W. J., and Janice R. Aldrich-Wright. "The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(ii) complexes." Dalton Transactions 44, no. 1 (2015): 87–96. http://dx.doi.org/10.1039/c4dt02773f.

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Dinuclear (2,2′:6′,2′′-terpyridine)platinum(ii) complexes were synthesised by tethering either thiol or pyridine based linkers. The cytotoxicity of the complexes was determined against human ovarian carcinoma cells (A2780) and its cisplatin-resistant sub-line A2780cis, as well as L1210 murine leukemia cells.

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28

Marelli, Ornella, Paola Franco, Gianfranco Canti, Nancy Prandoni, and Laura Ricci. "Induction of New Antigenic Properties on Dtic-Treated L1210 Clones." Tumori Journal 74, no. 4 (1988): 387–92. http://dx.doi.org/10.1177/030089168807400403.

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In vivo treatment of mouse leukemia L1210 with DTIC can induce new antigens on tumor cells that are not detectable on parental cells and that are transmissible as a genetic character. Moreover, L1210/DTIC is rejected by syngeneic hosts. The aim of this study was to investigate whether DTIC selects pre-existing immunogenic clones rather than inducing ex novo new antigenic determinants and to verify the number of induced antigens. L1210 leukemia was cloned in vitro and 4 clones were treated in vivo with DTIC. All the treated clones displayed antigenic properties since they were rejected by synge

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29

Su, Xiaomin, Yan Chen, Xiaobing Wang, et al. "PpIX induces mitochondria-related apoptosis in murine leukemia L1210 cells." Drug and Chemical Toxicology 37, no. 3 (2013): 348–56. http://dx.doi.org/10.3109/01480545.2013.866135.

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30

ISHIZUKA, MASAAKI, TORU MASUDA, SHIGETOSHI MIZUTANI, et al. "Induction of antitumor resistance to mouse leukemia L1210 by spergualins." Journal of Antibiotics 39, no. 12 (1986): 1736–43. http://dx.doi.org/10.7164/antibiotics.39.1736.

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31

Novotný, Ladislav, Eliška Balážová, Jozef šandula, Viliam Ujházy, and Vladimír Kéry. "Treatment of leukemia L1210 and P388 by arabinosylcytosine-polysaccharide conjugates." International Journal of Cancer 47, no. 2 (1991): 281–84. http://dx.doi.org/10.1002/ijc.2910470218.

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32

Kessel, D., and J. Zemlicka. "Accumulation and Metabolism of Adenallene by Murine Leukemia L1210 Cells." Archives of Biochemistry and Biophysics 308, no. 1 (1994): 222–25. http://dx.doi.org/10.1006/abbi.1994.1031.

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33

Simizu, Siro, Masaya Imoto, and Kazuo Umezawa. "Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells." Bioscience, Biotechnology, and Biochemistry 58, no. 9 (1994): 1549–52. http://dx.doi.org/10.1271/bbb.58.1549.

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34

Baker, Ayse, and Jeffrey R. Kanofsky. "QUENCHING OF SINGLET OXYGEN BY BIOMOLECULES FROM L1210 LEUKEMIA CELLS." Photochemistry and Photobiology 55, no. 4 (1992): 523–28. http://dx.doi.org/10.1111/j.1751-1097.1992.tb04273.x.

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35

KODAMA, Hiroshi, and DENSO. "Antitumor Effect of Humus Extract on Murine Transplantable L1210 Leukemia." Journal of Veterinary Medical Science 69, no. 10 (2007): 1069–71. http://dx.doi.org/10.1292/jvms.69.1069.

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36

McFadyen, W. David, Laurence P. G. Wakelin, Ian A. G. Roos, and Virginia A. Leopold. "Activity of platinum(II) intercalating agents against murine leukemia L1210." Journal of Medicinal Chemistry 28, no. 8 (1985): 1113–16. http://dx.doi.org/10.1021/jm00146a026.

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37

Hromas, Robert A., Paul A. Andrews, Michael P. Murphy, and C. Patrick Burns. "Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells☆." Cancer Letters 34, no. 1 (1987): 9–13. http://dx.doi.org/10.1016/0304-3835(87)90067-x.

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38

Moha, Rico. "Chemotherapy medication of Vincristine and Vinblastine." Cancer Research and Cellular Therapeutics 1, no. 1 (2017): 01–02. http://dx.doi.org/10.31579/2640-1053/007.

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Cancers treated with Vincristine and vinblastine include: acute leukemia, Hodgkin's and non- Hodgkin's lymphoma, neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma, Wilms' tumor, multiple myeloma, chronic leukemias, thyroid cancer, brain tumors, non-small cell lung cancer, bladder cancer, melanoma, and testicular cancer andIt is also used to treat some blood disorders. It is given by injection into a vein. Vincristine and vinblastine exhibit differential activity against tumors and normal tissues. In this work, a number of cultured cell lines were assayed for their sensitivity to the antiprolife

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39

Hogue, Douglas L., Kevin C. Hodgson, and Carol E. Cass. "Effects of inhibition of N-linked glycosylation by tunicamycin on nucleoside transport polypeptides of L1210 leukemia cells." Biochemistry and Cell Biology 68, no. 1 (1990): 199–209. http://dx.doi.org/10.1139/o90-026.

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Membrane polypeptides (relative mass (Mr) 48 000 – 55 000) associated with the equilibrative transport of nucleosides were identified in cultured murine leukemia (L1210/C2) cells by site-specific photolabeling with [3H]nitrobenzylthioinosine ([3H]NBMPR). Growth of cells in the presence of tunicamycin resulted in the gradual conversion of 3H-labeled polypeptides to a form that migrated more rapidly (Mr 42 000 – 47 000) during sodium dodecyl sulfate (SDS) – polyacrylamide gel electrophoresis. When plasma membrane fractions were photolabeled and incubated with O-glycanase or endoglycosidase F, th

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40

Leroy, Elisabeth, Donatella Lattuada, Claudia Casnicl, Paola Franco, and Ornella E. A. Marelli. "Down Regulation of Qa Gene Expression on Drug-Modified Tumor Cells." Tumori Journal 79, no. 6 (1993): 439–43. http://dx.doi.org/10.1177/030089169307900614.

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Background Mouse leukemia, L1210, strongly enhances its immunogenicity following in vivo treatment with 5-(3-3′-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC). Previous experiments have shown that transformed cells elicit a cell-mediated response accountable for rejection and resistance to a subsequent injection of parental tumor into a syngeneic host. L1210 expresses classical H-2 class I molecules, and since it has been shown that DTIC treatment does not modify the expression of these molecules, this is a suitable model to study nonclassical class I antigens, such as Qa2 glycoproteins,

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Kushev, Daniel, Galina Gorneva, Svetoslav Taxirov, Nadejda Spassovska, and Konstantin Grancharov. "Synthesis, Cytotoxicity and Antitumor Activity of Platinum(II) Complexes of Cyclopentanecarboxylic Acid Hydrazide." Biological Chemistry 380, no. 11 (1999): 1287–94. http://dx.doi.org/10.1515/bc.1999.164.

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Abstract New platinum(II) complexes of cyclopentanecarboxylic acid hydrazide (cpcah) were prepared, characterized by elemental analysis, IR and 1H NMR spectra, and evaluated for in vitro cytotoxicity in Friend leukemia (FL) and A2780 ovarian tumor cells, induction of apoptosis in FL cells, as well as for in vivo antitumor activity toward murine L1210 leukemia and Lewis lung carcinoma. The spectral analyses indicated a cissquare planar structure of the complexes with hydrazide ligand coordinated via the NH2 group. The compounds exerted significantly lower in vitro and in vivo toxicities as comp

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Kubíčková, Jana, Katarína Elefantová, Lucia Pavlikova, et al. "Screening of Phenanthroquinolizidine Alkaloid Derivatives for Inducing Cell Death of L1210 Leukemia Cells with Negative and Positive P-glycoprotein Expression." Molecules 24, no. 11 (2019): 2127. http://dx.doi.org/10.3390/molecules24112127.

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We describe the screening of a set of cryptopleurine derivatives, namely thienoquinolizidine derivatives and (epi-)benzo analogs with bioactive phenanthroquinolizidine alkaloids that induce cytotoxic effects in the mouse lymphocytic leukemia cell line L1210. We used three variants of L1210 cells: i) parental cells (S) negative for P-glycoprotein (P-gp) expression; ii) P-glycoprotein positive cells (R), obtained by selection with vincristine; iii) P-glycoprotein positive cells (T), obtained by stable transfection with a human gene encoding P-glycoprotein. We identified the most effective deriva

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Yamada, Takeshi, Haruka Kogure, Minami Kataoka, Takashi Kikuchi, and Tomoya Hirano. "Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp." Marine Drugs 18, no. 6 (2020): 320. http://dx.doi.org/10.3390/md18060320.

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Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia,

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Witter, Ludwig, Timm Anke, and Olov Sterner. "A New Inhibitor of Synovial Phospholipase A2 from Fermentations of Penicillium Sp. 62-92." Zeitschrift für Naturforschung C 53, no. 1-2 (1998): 60–64. http://dx.doi.org/10.1515/znc-1998-1-212.

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AbstractPenidiamide, a new tripetide containing dehydrotryptamine, glycine and anthranilic acid linked together by two amide bonds, and oxindole were isolated from submerged cultures of Penicillium sp. 62-92 . Both compounds preferentially inhibited human synovial phospholipase A2, penidiamide with an IC50 of 30 μᴍ and oxindole of 380 μᴍ. With the exception of U 937 cells (leukemia, human), no cytotoxic activities were detected against HL-60- (leukemia, human), HeLa S3- (epitheloid carcinoma, human), BHK 21- (kidney fibroblasts, hamster), and L1210-cells (leukemia, mouse). No antimicrobial act

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Ahmad, S., L. Okine, B. Le, P. Najarian, and D. T. Vistica. "Elevation of glutathione in phenylalanine mustard-resistant murine L1210 leukemia cells." Journal of Biological Chemistry 262, no. 31 (1987): 15048–53. http://dx.doi.org/10.1016/s0021-9258(18)48136-7.

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Schmid, Franz A., Glenys M. Otter, and Ikuo Hirano. "L1210 leukemia hybrids isolated after fusion of alkylating agent-resistant sublines." Leukemia Research 12, no. 1 (1988): 67–70. http://dx.doi.org/10.1016/s0145-2126(98)80010-6.

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Burns, C. Patrick, James A. North, Craig J. Mossman, and Leah M. Ingraham. "Modification of the fatty acid composition of L1210 leukemia subcellular organelles." Lipids 23, no. 6 (1988): 615–18. http://dx.doi.org/10.1007/bf02535607.

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Crawford, C. R., C. Y. Ng, L. D. Noel, and J. A. Belt. "Nucleoside transport in L1210 murine leukemia cells. Evidence for three transporters." Journal of Biological Chemistry 265, no. 17 (1990): 9732–36. http://dx.doi.org/10.1016/s0021-9258(19)38732-0.

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Cory, A. H., I. A. Shibley, J. M. Chalovich, and J. G. Cory. "Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity." Journal of Biological Chemistry 268, no. 1 (1993): 405–9. http://dx.doi.org/10.1016/s0021-9258(18)54165-x.

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Schoettle, Sarah L., Leesa B. Crisp, Eve Szabados, and Richard I. Christopherson. "Mechanisms of Inhibition of Amido Phosphoribosyltransferase from Mouse L1210 Leukemia Cells†." Biochemistry 36, no. 21 (1997): 6377–83. http://dx.doi.org/10.1021/bi962598m.

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