Relevant bibliographies by topics / Langerhans cells (LC)

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Langerhans cells (LC)'

Author: Grafiati
Published: 31 May 2025
Last updated: 31 July 2025

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Journal articles on the topic "Langerhans cells (LC)"

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MONTERO, A. J., C. M. DÍAZ-MONTERO, A. MALPICA, P. T. RAMIREZ, and J. J. KAVANAGH. "Langerhans cell histiocytosis of the female genital tract: A literature review." International Journal of Gynecologic Cancer 13, no. 3 (2003): 381–88. http://dx.doi.org/10.1136/ijgc-00009577-200305000-00021.

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Langerhans cell histiocytosis (LCH) is a rare malignant disease involving the accumulation of a monoclonal proliferation of cells in various organs, that phenotypically resemble Langerhans cells (LC). LCH is not merely a hyperplasia of LC, as it typically affects organs that are outside of their normal physiologic distribution. Normal Langerhans cells are bone marrow-derived dendritic cells that populate the epidermis and are distinguished by the presence of Birbeck granules and cell surface protein CD1a. LC act as sentinels; they recognize, internalize, and process antigens encountered in the
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Tazi, Abdellatif, Joelle Moreau, Anne Bergeron, Stéphane Dominique, Allan J. Hance, and Paul Soler. "Evidence That Langerhans Cells in Adult Pulmonary Langerhans Cell Histiocytosis Are Mature Dendritic Cells: Importance of the Cytokine Microenvironment." Journal of Immunology 163, no. 6 (1999): 3511–15. http://dx.doi.org/10.4049/jimmunol.163.6.3511.

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Abstract Because Langerhans cells (LC) in peripheral tissues are generally “immature” cells with poor lymphostimulatory activity, the contribution of immune responses initiated by LC to the pathogenesis of pulmonary LC histiocytosis (LCH) has been uncertain. In this study we demonstrate that LC accumulating in LCH granulomas are phenotypically similar to mature lymphostimulatory dendritic cells present in lymphoid organs. LC in LCH granulomas intensely expressed B7-1 and B7-2 molecules, whereas normal pulmonary LC and LC accumulating in other pathologic lung disorders did not express these cos
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Barrett, A. W., A. T. Cruchley, and D. M. Williams. "Oral Mucosal Langerhans' Cells." Critical Reviews in Oral Biology & Medicine 7, no. 1 (1996): 36–58. http://dx.doi.org/10.1177/10454411960070010301.

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Langerhans' cells (LC) are dendritic, antigen-presenting cells present within the epithelium of skin and mucosa, including that of the oral cavity. This article reviews the literature on the phenotypic and functional features of oral mucosal Langerhans' cells, and speculates on other aspects by extrapolating from data on their epidermal counterparts.
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Kang, K., M. Kubin, K. D. Cooper, S. R. Lessin, G. Trinchieri, and A. H. Rook. "IL-12 synthesis by human Langerhans cells." Journal of Immunology 156, no. 4 (1996): 1402–7. http://dx.doi.org/10.4049/jimmunol.156.4.1402.

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Abstract IL-12 is a 70-kDa heterodimeric cytokine composed of a p35 chain and p40 chain. This cytokine exerts a powerful positive regulatory influence on the development of Th1 helper T-cell immune responses and is a potent inducer of IFN-gamma production and cytotoxic T cell differentiation and function. Because epidermal Langerhans cells (LC) are important members of the dendritic APC lineage family critical for initiating cell mediated immune responses, we examined LC for their ability to produce IL-12. Epidermal cell (EC) suspensions obtained from volunteers were enriched for, or depleted
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Wang, Jie, Nirmal Parajuli, Qiyan Wang, et al. "MiR-23a Regulates Skin Langerhans Cell Phagocytosis and Inflammation-Induced Langerhans Cell Repopulation." Biology 12, no. 7 (2023): 925. http://dx.doi.org/10.3390/biology12070925.

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Langerhans cells (LCs) are skin-resident macrophage that act similarly to dendritic cells for controlling adaptive immunity and immune tolerance in the skin, and they are key players in the development of numerous skin diseases. While TGF-β and related downstream signaling pathways are known to control numerous aspects of LC biology, little is known about the epigenetic signals that coordinate cell signaling during LC ontogeny, maintenance, and function. Our previous studies in a total miRNA deletion mouse model showed that miRNAs are critically involved in embryonic LC development and postnat
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Reis e Sousa, C., P. D. Stahl, and J. M. Austyn. "Phagocytosis of antigens by Langerhans cells in vitro." Journal of Experimental Medicine 178, no. 2 (1993): 509–19. http://dx.doi.org/10.1084/jem.178.2.509.

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Dendritic cells (DC) isolated from lymphoid tissues are generally thought to be nonphagocytic in culture. It has therefore been unclear how these cells could acquire particulate antigens such as microorganisms for initiation of primary immune responses. Lymphoid DC derive in part from cells that have migrated from nonlymphoid tissues, such as Langerhans cells (LC) of skin. The ability of LC to internalize a variety of particles was studied by electron, ultraviolet, phase, and differential interference contrast microscopy, and by two-color flow cytometry. Freshly isolated LC in epidermal cell s
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Geissmann, Frederic, Yves Lepelletier, Sylvie Fraitag, et al. "Differentiation of Langerhans cells in Langerhans cell histiocytosis." Blood 97, no. 5 (2001): 1241–48. http://dx.doi.org/10.1182/blood.v97.5.1241.

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Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease. In bone and chronic lesions, LCH cells had immature phenotype and function. They coexpressed LC antigens CD1a and Langerin together with monocyte antigens CD68 and CD14. Class II antigens were intracellular and LCH cells almost never expressed CD83 or CD86 or dendritic cell (DC)–Lamp, despite their CD40
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Schuler, G., and R. M. Steinman. "Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro." Journal of Experimental Medicine 161, no. 3 (1985): 526–46. http://dx.doi.org/10.1084/jem.161.3.526.

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Murine epidermal Langerhans cells (LC) have been studied in tissue culture and compared to spleen dendritic cells (DC). LC comprised 3% of the starting cell suspensions and were distinguished from keratinocytes by cytology and reactivity with anti-Ia and anti-Mac-1 monoclonal antibodies. The LC were nonadherent, had a low buoyant density, did not proliferate, and could be enriched to 10-50% purity. LC continued to exhibit Ia and Mac-1 antigens for 4 d in culture. However, LC rapidly lost Birbeck granules, Fc receptors, F4/80 antigen, and cytochemical reactivity for nonspecific esterase and mem
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Hamada, M., M. Takechi, and C. Itakura. "Langerhans' Cells in Equine Cutaneous Papillomas and Normal Skin." Veterinary Pathology 29, no. 2 (1992): 152–60. http://dx.doi.org/10.1177/030098589202900208.

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Langerhans' cells (LC) were investigated immunohistochemically and electron microscopically in normal equine epidermis and 133 equine cutaneous papillomas experimentally induced in five 2-year-old Thoroughbred horses. Class II major histocompatibility complex antigen-positive dendritic LC were found in the normal epidermis and ultrastructurally had the characteristic Birbeck's granules. In the developing phase of the papillomas, LC were significantly decreased in number and size, indicative of a hypofunctional state. In the regressing phase of the papillomas, LC were markedly increased in numb
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Caux, C., C. Massacrier, C. Dezutter-Dambuyant, et al. "Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen." Journal of Immunology 155, no. 11 (1995): 5427–35. http://dx.doi.org/10.4049/jimmunol.155.11.5427.

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Abstract Earlier studies have concluded that fresh Langerhans cells (LC) are able to capture and process native Ags, whereas cultured LC have lost these functions while acquiring the capacity to prime naive T cells. Herein we studied the functions of human dendritic/Langerhans cells (d-Lc) generated in vitro by culturing CD34+ hemopoietic progenitor cells in the presence of granulocyte-macrophage CSF (GM-CSF) + TNF-alpha. Less than 50 d-Lc were found to strongly stimulate the proliferation of 2.5 x 10(4) allogeneic naive CD4+ T cells. Furthermore, six to 50 d-Lc induced half-maximal proliferat
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Dissertations / Theses on the topic "Langerhans cells (LC)"

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Gerber--Tichet, Elina. "Le rôle des cellules de Langerhans (LCs) au cours du processus de vaccination basé sur les adénovirus humains." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2025. https://ged.scdi-montpellier.fr/florabium45/jsp/nnt.jsp?nnt=2025UMONT003.

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Les cellules de Langerhans (LCs) sont des cellules présentatrices d'antigènes (APCs) professionnelles résidentes de certains tissus ou muqueuses et font partie de notre première ligne de défense. Les LCs se trouvent non seulement dans certaines muqueuses et autres tissus lymphoïdes, mais aussi dans la peau, l'une des principales voies d'entrée des agents pathogènes. Impliquées dans de nombreuses réponses antivirales, les LCs sont capables de scanner l'environnement à la recherche d'agents pathogènes grâce à leurs projections cytoplasmiques. Outre la détection des pathogènes, les LCs jouent éga
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Book chapters on the topic "Langerhans cells (LC)"

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Caux, C., B. Vanbervliet, C. Massacrier, et al. "Characterization of Human CD34+ Derived Dendritic/Langerhans Cells (D-Lc)." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1971-3_1.

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Rowden, G. "Human Immunodeficiency Virus (HIV) and its Interactions with Epidermal Langerhans Cells (LC)." In Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3942-1_10.

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Journal articles
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