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Dissertations / Theses on the topic 'Lassa fever'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Wilkinson, Ann. "The process and practice of diagnosis : innovations in diagnostics for Lassa fever in Sierra Leone." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/47209/.

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This thesis is about the process and practice of diagnosis and the implications of new diagnostic technologies in low resource settings. As a setting and a disease which has seen significant investment in diagnostics, Lassa fever in Sierra Leone has been selected as a case study to examine these themes. In this thesis, 'new diagnostic technologies' refers to laboratory-based diagnostics which are fast, reliable, accurate and can be used in low income settings. The starting point of this thesis is a narrative surrounding such technologies which suggests that they will revolutionise low income h
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2

Krasilnikova, Lydia A. "Metagenomic investigation of co-infections of Ebola virus disease and Lassa fever patients." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/106113.

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Thesis: M. Eng. in Computer Science and Molecular Biology, Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 37).<br>Sequencing followed by metagenomic analysis is an extremely promising method for broad, unbiased disease profiling of patients for disease surveillance and diagnosis. Here, we use two popular metagenomics tools in union, k-mer-based Kraken with reads and BLAST- and LCAbased MEGAN with assembled contiguous sequence. We analyze sequence from 4
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3

Baillet, Nicolas. "Pathologie comparée de la fièvre de Lassa chez le singe cynomolgus : mécanismes pathogéniques précoces, réponses immunitaires et marqueurs d’infection." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1307.

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Le virus Lassa entraine une fièvre hémorragique endémique en Afrique de l’Ouest et représente un problème de santé publique. Les connaissances sur la pathogénèse et les réponses immunitaires associées à la maladie sont partielles. Nous avons suivi les paramètres pathologiques, virologiques et immunologiques associés aux infections létales et non létales du LASV chez le singe cynomolgus. Le tableau clinique a été caractérisé par une dépression, une anorexie, une perte de poids et une asthénie chez les animaux survivants, tandis que ces mêmes symptômes ont été accompagnés de fièvre, de difficult
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4

Cedergren, Linda. "Expression of recombinant protein including an His-tag to facilitate purification for diagnosis of CCHF and Lassa Viruses." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7064.

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<p>Abstract</p><p>Crimean-Congo Hemorrhagic Fever virus (CCHF) and Lassa virus are giving sources illness to humans. In addition to zoonotic transmission, CCHF and Lassa virus can spread from person to person. After a short incubation period, CCHF and Lassa virus infections are characterized by a sudden onset of high fever, chills, headache and cough just like flu. Even some people are vomiting and have diarrhoea. After a few days of illness hemorrhagic manifestations occur. Treatment options for CCHF and Lassa viruses are limited, and there is no vaccine available for use in humans. The purpo
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5

Duvignaud, Alexandre. "Aspects cliniques, biologiques et pronostiques de la fièvre de Lassa en contexte endémo-épidémique en Afrique de l’Ouest : exemple du Nigeria." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0254.

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La fièvre de Lassa, maladie endémique à recrudescence épidémique saisonnière, est avec 300 000 cas et 5000 décès annuels estimés à travers toute l’Afrique de l’Ouest considérée comme une priorité en terme de recherche. Ces dernières années, le Nigeria a rapporté un nombre de cas annuel en constante augmentation, dépassant désormais le millier. Mais cinquante ans après sa découverte, les connaissances sur la maladie restent parcellaires et la recherche clinique peu structurée. L’efficacité du seul traitement recommandé, la ribavirine, est aujourd’hui remise en cause. Il apparait donc urgent de
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6

Qi, Xiaoxuan. "Structural and functional studies of novel mechanisms of Lassa fever virus nucleoprotein in immune suppression, viral RNA transcription and replication." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3601.

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Lassa fever virus is one of the most dangerous viruses of arenaviridae family, causing more than 500,000 infections per year in Africa. The fatality rate for hospitalized patients is as high as 20%. Due to the high fatality and lack of efficient licensed drugs and vaccines to treat and prevent, Lassa fever virus is classified as a Category A priority pathogen and biosafety level-4 agent by the Centers for Disease Control and Prevention of the USA. Cases were also found in the Americas and European countries, highlighting its potency to be a bioterrorism weapon. Like other areanaviruses, Lassa
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7

Port, Julia Rebecca [Verfasser], Lars [Akademischer Betreuer] Redecke, and Tamás [Akademischer Betreuer] Laskay. "Implications of T-lymphocyte homing in Lassa fever pathogenesis and transmission / Julia Rebecca Port ; Akademische Betreuer: Lars Redecke, Tamás Laskay." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1228017913/34.

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8

Wallat, Gregor D. "Structure determination of the major outer membrane protein from Campylobacter jejuni, &, Structural and functional studies of the endonuclease from Lassa virus." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/8112.

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The major outer membrane protein, MOMP, is the main protein in the outer membrane of pathogenic Campylobacter bacteria. Infection with Campylobacter is the principle cause of severe enteritis and untreated may result in non-trauma related paralysis. Studies have shown, that MOMP can act as antigen and thus has the potential to provide protection by induced humoral immunity. In our study, we expressed recombinant MOMP in Escherichia1coli, developed an alternative method to extract the outer membrane protein from its lipid environment and solved and characterised its crystal structure. The infor
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9

Offor, Joy. "Lassa fever epidemic outbreak causing maternal mortality on pregnant women : A statistical and systematic review on prevalence and occurrence of maternal mortality in Nigeria." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-42026.

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Introduction/background: Epidemics of infectious diseases (ID) are re-occurring now more often and spreads faster into many different parts of the world due to globalization. The increasing evidence of climate change and man-made events have shown impacts to increase the emergency and re-emerging of animal- borne IDs. Studies claims that background factors of these IDs are biological, environmental and human-lifestyle related changes. The pathogen Lassa fever virus (LASV) is a zoonotic organismthat circulates in rodent reservoirs, and the animal´s hosts are rodent species (rats) of the genus M
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10

Schaeffer, Justine. "Étude in vitro et ex vivo de la réponse des cellules dendritiques à l’infection par le virus Lassa." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1249/document.

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Le virus Lassa (LASV) induit une fièvre hémorragique chez l’homme et est responsable de 3 000 à 5 000 décès par an. Aucun vaccin ou traitement efficace contre LASV n’est disponible, et les mécanismes de pathogenèse de la fièvre de Lassa sont encore mal compris. Des études chez l’homme et le primate suggèrent que la réponse interféron de type I (IFN-I) et de la réponse T sont critiques pour la survie de l’hôte. Nous nous sommes intéressés à la réponse des cellules dendritiques (DC) à LASV, car elles peuvent à la fois produire des IFN-I et induire la réponse T. Nous avons étudié les DC plasmacyt
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11

Russier, Marion. "Cellules NK et fièvres hémorragiques virales : étude de leur rôle dans la mise en place des réponses immunes et dans la pathogenèse lors de l'infection par les virus Lassa et Ebola." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-00835079.

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Les fièvres hémorragiques à virus Lassa (LASV) et Ebola (EBOV) représentent un important problème de santé publique en Afrique. Les réponses immunes et la pathogenèse associées à ces maladies sont peu connues. Les cellules NK ont un rôle important dans la réponse immune innée par leurs propriétés cytotoxiques, mais également dans l'induction des réponses adaptatives par leur production de cytokines et leurs interactions avec les cellules dendritiques (DC) et les macrophages. Ce projet s'attache à comprendre le rôle des cellules NK dans le contrôle de la réplication virale et dans l'induction d
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12

"Characterization of arenaviral soluble glycoprotein biosynthesis and evaluation of Lassa virus-like particles as vaccine candidates for Lassa hemorrhagic fever." Tulane University, 2010.

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Lassa hemorrhagic fever is a disease endemic to Western and Central Africa. It is also the most commonly imported hemorrhagic fever disease with numerous cases reported in travelers to the region throughout the forty one years since its first characterization in Nigeria. Lassa fever afflicts an estimated 300,000 or more people in Western Africa each year, with approximately 5,000 fatalities. These statistics may underreport the actual number of infections and overall fatality rate from the disease; in that modern, highly sensitive, specific, and rapid recombinant protein-based diagnostics rece
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13

"Untargeted Lcms Serum Metabolomics Of The Sierra Leonean Lassa Fever Patient And Metaanalysis Of The Virion Proteome." 2016.

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14

"Knowledge, attitude, and practices of Lassa fever transmission and perceived risk increase likelihood of rodent control activities and reduction in homes." Tulane University, 2021.

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15

Mota, Tiago José Abreu. "Development of a Lassa/Rabies virus vaccine based on the rabies vector." Doctoral thesis, 2019. http://hdl.handle.net/1822/66881.

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Tese de Doutoramento em Medicina<br>Lassa fever (LF), is a viral hemorrhagic fever caused by Lassa virus (LASV), for which neither an approved vaccine or effective treatment is available. LASV is an endemic virus in western Africa and a major health and economic burden, causing an estimate 100,000-300,000 infections yearly, with the number of reported infections increasing in the last years. This thesis describes the development of LASSARAB, a dual LF and rabies vaccine based on recombinant rabies vector. Rabies is another equally important disease in Africa that is estimated to cause th
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16

Smit, Andre-Karl. "Genetic variation in two morphologically similar South African Mastomys species (Rodentia : Muridae)." Thesis, 2012. http://hdl.handle.net/10210/7157.

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M.A.<br>Two species of multimammate mouse, Mastomys coucha and M. natalensis are common, and widely distributed in southern Africa, occurring sympatrically in some areas, and allopatrically in others. The limits of their distribution are only provisional so far. As they share a high degree of morphological similarity, they are, as yet, impossible to identify with certainty in the field. Each species of multimammate mouse carries important diseases: with M. coucha being a carrier for the bacterium causing plague, and M. natalensis carrying the virus causing Lassa fever. In many areas, multimamm
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17

"Development Of Rapid Diagnostic Tests For The Point-of-care Detection Of Lassa And Ebola Viral Hemorrhagic Fevero." 2015.

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