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1

Eke, M., and F. Adiri. "Cross-sectional Study of the knowledge, attitude, and preventive practices towards Lassa fever among Residents of Karu, Abuja, Nigeria." Tropical Journal of Health Sciences 31, no. 4 (2025): 01–11. https://doi.org/10.4314/tjhc.v31i4.1.

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Lassa fever is associated with high morbidity and mortality with several laboratory-confirmed cases and deaths reported in Nigeria and the Federal Capital Territory (FCT-Abuja). This study assessed the knowledge, attitude, and preventive practices towards Lassa fever among residents of Karu, Abuja, Nigeria. A cross-sectional study design, using a multistage sampling technique, to select 210 consenting adults was used. A structured, self-administered, pre-coded, pre-tested questionnaire was used to collect data on socio-demographic characteristics, knowledge, attitude, and preventive practices
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2

Ebenezer, Abdullahi, and Samuel Adesewa. "LASSA FEVER MITIGATION: COMBATTING AN EMERGING INFECTIOUS DISEASE THREAT." Global Journal of Medical and Pharmaceutical Sciences 02, no. 04 (2023): 01–07. http://dx.doi.org/10.55640/gjmps-abcd05.

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Lassa fever, caused by the Lassa virus, is a severe viral hemorrhagic fever with significant public health implications in West Africa. The disease poses a substantial burden on affected communities, leading to high morbidity and mortality rates. As an emerging infectious disease threat, Lassa fever presents challenges in terms of prevention, diagnosis, and control. This paper explores strategies for mitigating the risk of Lassa fever transmission and outbreak escalation. Key components of Lassa fever mitigation efforts include public health education, community engagement, surveillance and ea
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McCormick, Joseph B., Isabel J. King, Patricia A. Webb, et al. "Lassa Fever." New England Journal of Medicine 314, no. 1 (1986): 20–26. http://dx.doi.org/10.1056/nejm198601023140104.

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4

Coyle, Amanda L. "Lassa fever." Nursing 46, no. 7 (2016): 69–70. http://dx.doi.org/10.1097/01.nurse.0000482873.70955.7b.

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5

Roberts, Amy, and Charles Kemp. "Lassa Fever." Journal of the American Academy of Nurse Practitioners 14, no. 7 (2002): 289–90. http://dx.doi.org/10.1111/j.1745-7599.2002.tb00127.x.

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6

Banatvala, J. E. "Lassa fever." BMJ 293, no. 6557 (1986): 1256–57. http://dx.doi.org/10.1136/bmj.293.6557.1256.

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7

Bannister, B. "Lassa fever." BMJ 302, no. 6768 (1991): 114. http://dx.doi.org/10.1136/bmj.302.6768.114-b.

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8

Asogun, Danny A., Stephan Günther, George O. Akpede, Chikwe Ihekweazu, and Alimuddin Zumla. "Lassa Fever." Infectious Disease Clinics of North America 33, no. 4 (2019): 933–51. http://dx.doi.org/10.1016/j.idc.2019.08.002.

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9

Ossai, Edmund Ndudi, Ogah Emeka Onwe, Nnaemeka Philips Okeagu, Amarachi Laura Ugwuoru, Thankgod Kelechi Eze, and Augustine Sunday Nwede. "Knowledge and preventive practices against Lassa fever among heads of households in Abakaliki metropolis, Southeast Nigeria: A cross-sectional study." Proceedings of Singapore Healthcare 29, no. 2 (2020): 73–80. http://dx.doi.org/10.1177/2010105819899120.

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Background: Lassa fever is associated with high morbidity and mortality. Objectives: This study aimed to determine the knowledge and preventive measures against Lassa fever among heads of households in Abakaliki metropolis, Southeast Nigeria. Methods: This was a descriptive cross-sectional study. A four-stage sampling design was used to select 420 respondents from Abakaliki metropolis. A good knowledge of Lassa fever was determined by the proportion of respondents scoring ⩾50% in 15 variables. Good preventive practices against Lassa fever were determined by the proportion of respondents obtain
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10

Patassi, Akouda Akessiwe, Dadja Essoya Landoh, Agballa Mebiny-Essoh Tchalla, et al. "Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016." Case Reports in Infectious Diseases 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/8242313.

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Background. Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo. Case Presentation. The two first Lassa fever cases occurred in two expatriate’s health professionals working in Togo for more than two years. The symptoms appeared among two health professionals of a clinic located in Oti district in the north of the country. The absence of clinical improvement after antimalarial treatment and the worsening of clinical symptoms led to the medical evacuation. The de
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11

Egejuru, Ngozi Chidozie, Oluwatobiloba Victor Omotayo, Omanma Chidima Uche,, and Sarumi Olusegun Ajibola. "Development of a Fuzzy Logic Predictive Model for Lassa Fever Risk Detection." Advances in Multidisciplinary and scientific Research Journal Publication 10, no. 3 (2022): 83–100. http://dx.doi.org/10.22624/aims/maths/v10n2p7.

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Abstract- Although there is no vaccine to prevent Lassa fever, symptomatic therapy increases the patient's chances of survival. The antiviral medicine Ribavirin demonstrated being effective when administered early enough in the illness. Lassa fever clinical research is difficult. To lower the mortality and morbidity of Lassa fever, urgent research is underway. Through a search of pertinent literature and organized interviews with medical professionals, risk factors for Lassa fever were discovered. Fuzzy Logic Toolbox, MATLAB® R2009a, was used to create and simulate the model for predicting Las
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12

Ekuma AE and Akpan IS. "Lassa fever and infection control: Knowledge, attitudes and practice in a University Teaching Hospital in Uyo, Nigeria." Ibom Medical Journal 10, no. 1 (2017): 40–47. http://dx.doi.org/10.61386/imj.v10i1.145.

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Context: Lassa fever is a deadly viral hemorrhagic disease that is endemic in Nigeria with recurrent outbreaks that often affect healthcare workers. Hospital infection control can potentially limit the impact of outbreaks of this disease in healthcare settingsObjective: To determine the knowledge attitudes and practices toward Lassa fever and infection control among medical doctors and students in Uyo, Nigeria.Methods: This was a cross sectional survey of knowledge attitude and practice among medical students, house officers and resident doctors undergoing training in the University of Uyo Tea
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13

Obekpa, Isaiah Obekpa, Chibueze Ezema Godian, Tariemi Adika David, et al. "Psychiatric Symptoms in People with Probable or Confirmed Lassa Fever in a Military Hospital in North Central Nigeria: A Case Series." Trop J Med Res 21, no. 1 (2022): 247–52. https://doi.org/10.5281/zenodo.7120667.

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<strong>ABSTRACT</strong> Lassa fever (LF) is an important public health disease in West Africa, where it is endemic. The early phase of the disease is characterised by non-specific symptoms mimicking malaria and other common febrile illnesses. Neuro-psychiatric symptoms are not commonly reported and psychiatrists are not usually part of the management team. Surviving Lassa fever patients with psychiatric symptoms tend to have long hospital stays. The study is aimed at describing the pattern of neuropsychiatric symptoms in people with probable or confirmed Lassa fever at the 161 Nigerian Air f
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14

Ifejube, O. J., S. O. Babalola, I. O. Mukaila, and A. O. Badewa. "A GIS-BASED APPROACH TO RISK MAPPING OF LASSA FEVER OUTBREAK IN AKURE SOUTH LOCAL GOVERNMENT AREA, NIGERIA." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-4/W3-2021 (January 10, 2022): 147–53. http://dx.doi.org/10.5194/isprs-archives-xlvi-4-w3-2021-147-2022.

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Abstract. Lassa fever is an acute viral illness, which is endemic in some counties in West Africa, including Guinea, Liberia, Sierra Leone and parts of Nigeria. It is caused by the Lassa virus, which is primarily hosted by multi-mammate rats that live in and around houses. This study sees the need to enhance public awareness by producing risk maps of Lassa fever for the study area. In a bid to understand and predict the prevalence of the disease in Akure South Local Government Area. Temporal and spatial analyses of Lassa fever cases were carried out, information about related environmental var
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15

Alenoghena, I., and V. Omuemu. "Perception of Risk for Lassa Fever among Residents of a Rural Community in Edo State, Nigeria." Journal of Epidemiological Society of Nigeria 4, no. 1 (2021): 29–38. http://dx.doi.org/10.46912/jeson.40.

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Background: The prevention and control of Lassa fever depends on the adoption of appropriate behavioural practices. The expected changes are best explained using the Health Belief Model. The study investigated respondents’ perception of their risk for Lassa fever infection and its associated factors in Akhalowa community of Edo State.&#x0D; Methods: This cross-sectional study was conducted among eligible heads of households using a structured interviewer-administered questionnaire. Data were analyzed using descriptive and inferential statistics on IBM SPSS version 22.0. A p-value &lt; 0.05 at
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Oye, Modupe Jokotola, Adewale Oladayo Akinpelu, and Ayobami Susan Oyedeji. "Lassa Fever Disease: Knowledge of Aetiology and Prevention Practices in Rural Communities in Ado Local Government Area of Ekiti State, Nigeria." Research and Reviews in Intensive and Critical Care Nursing 2, no. 1 (2024): 12–25. https://doi.org/10.5281/zenodo.10553847.

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<em>Recently, Nigeria has been experiencing</em><em> significant public health challenges from</em><em> infectious disease outbreaks including Lassa fever, Ebola, yellow fever, measles, monkey pox and COVID-19 among others</em><em>. Lassa Fever Disease (LFD) is an acute viral hemorrhagic and a life-threatening condition causing morbidity and mortality. </em><em>This study investigated the knowledge of etiology and preventive practices of Lassa Fever Disease in rural communities in Ado local government area of Ekiti State in other to reduce the disease burden.</em><em> </em><em>A cross-sectiona
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Amoo, Olufemi Samuel, Joseph Shaibu, Olumuyiwa Salu, et al. "Comparative Assessment of Knowledge, Attitude/Practices and Prevention of Lassa fever among Community Dwellers and Contacts of Confirmed Patients in Endemic Areas of Ondo State, Nigeria." European Journal of Medical and Health Sciences 3, no. 4 (2021): 137–44. http://dx.doi.org/10.24018/ejmed.2021.3.4.962.

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Background: The current resurgence and transmission dynamics of Lassa fever (LF) within an endemic community in Nigeria calls for concern. Lassa fever virus is known to be transmitted from rodents to humans as well as from human to human. This study aims to compare the knowledge, attitude/practices and prevention of Community dwellers (CD) and Contacts of confirmed Lassa fever patients (CCP) with respect to LF in an endemic area in Nigeria. Methodology: This is a comparative cross-sectional study conducted between 2018 and 2019 during an outbreak of LF disease in Ondo State, Nigeria. A total o
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18

Fisher-Hoch, Susan P., and Joseph B. McCormick. "Lassa fever vaccine." Expert Review of Vaccines 3, no. 2 (2004): 189–97. http://dx.doi.org/10.1586/14760584.3.2.189.

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19

Bhadelia, Nahid. "Understanding Lassa fever." Science 363, no. 6422 (2019): 30. http://dx.doi.org/10.1126/science.aav8958.

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20

Daboer, JC, OY Sodipo, L. Okoro, et al. "Comparison of Lassa fever prevention practices between public and private primary health care facilities in Jos, Plateau state, Nigeria." Journal of Epidemiological Society of Nigeria 2 (July 18, 2020): 79–90. http://dx.doi.org/10.46912/jeson.26.

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Background: Lassa fever is endemic in Nigeria and health care workers are at a high risk of contracting and transmitting the infection. This study compares Lassa fever prevention practices among health care providers in public and private Primary Health Care facilities in Jos.Methods: The study used a comparative cross-sectional design to study health care workers in 29 Primary Health Care facilities selected using a two-stage sampling technique. All health care workers who attended to patients were interviewed using a semistructured interviewer-administered questionnaire. Data were analysed u
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21

Popova, O. D., O. V. Zubkova, T. A. Ozharovskaia, et al. "Review of candidate vaccines for the prevention of Lassa fever." Problems of Virology 66, no. 2 (2021): 91–102. http://dx.doi.org/10.36233/0507-4088-33.

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The Lassa virus one of the main etiological agent of hemorrhagic fevers in the world: according to WHO estimates, it affects 100,000 to 300,000 people annually, which results in up to 10,000 deaths [1]. Although expansion of Lassa fever caused by this pathogen is mostly limited to the West African countries: Sierra Leone, Liberia, Guinea and Nigeria, imported cases have been historically documented in Europe, the United States of America (USA), Canada, Japan, and Israel [2]. In 2017, WHO included the Lassa virus in the list of priority pathogens in need of accelerated research, development of
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Khare, Basant, Dolly Jain, Monika Jain, Sameeksha Jain, Pushpendra Kumar Khangar, and Deepak Kumar Jain. "An Overview of Lassa fever, an Rising Old World Haemorrhagic Viral Disease." Asian Journal of Dental and Health Sciences 2, no. 1 (2022): 20–26. http://dx.doi.org/10.22270/ajdhs.v2i1.12.

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Lassa fever is an acute immunosuppressive illness of increasing public health concern causing severe morbidity and significant mortality especially in epidemic cases. Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting, chest and abdominal pain. The virus exhibits persistent, asymptomatic infection with profuse urinary virus excretion in the ubiquitous rodent vector, Mastomys natalensis. Lassa fever is endemic in West Africa and has been re
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Musa, Adesola, Kazeem Osuolale, Dayo Lawal, et al. "Modelling Seasonal Variation and Lassa Fever Outbreak in Nigeria: A Predictive Approach." International Journal of Data Science and Analysis 10, no. 5 (2024): 100–108. https://doi.org/10.11648/j.ijdsa.20241005.12.

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&amp;lt;i&amp;gt;Background&amp;lt;/i&amp;gt;: Lassa fever, a severe viral hemorrhagic fever caused by the Lassa virus, is a significant public health concern in West Africa, particularly in Nigeria. First identified in the 1950s, Lassa fever has been a persistent threat, causing outbreaks annually. This study investigates the temporal patterns and trends of Lassa fever outbreaks in Nigeria between 2017 and 2023, leveraging a comprehensive dataset from the Nigerian Centre for Disease Control (NCDC). &amp;lt;i&amp;gt;Objective&amp;lt;/i&amp;gt;: The goal of this study is to analyze the seasonal
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Sattler, Rachel A., Slobodan Paessler, Hinh Ly, and Cheng Huang. "Animal Models of Lassa Fever." Pathogens 9, no. 3 (2020): 197. http://dx.doi.org/10.3390/pathogens9030197.

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Lassa virus (LASV), the causative agent of Lassa fever, is estimated to be responsible for up to 300,000 new infections and 5000 deaths each year across Western Africa. The most recent 2018 and 2019 Nigerian outbreaks featured alarmingly high fatality rates of up to 25.4%. In addition to the severity and high fatality of the disease, a significant population of survivors suffer from long-term sequelae, such as sensorineural hearing loss, resulting in a huge socioeconomic burden in endemic regions. There are no Food and Drug Administration (FDA)-approved vaccines, and therapeutics remain extrem
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Lafoux, Blaise, Gustave Fourcaud, Jimmy Hortion, et al. "Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever." PLOS Pathogens 21, no. 4 (2025): e1013111. https://doi.org/10.1371/journal.ppat.1013111.

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Lassa fever is a highly lethal hemorrhagic fever endemic to West Africa. In the absence of efficient prophylactic or therapeutic countermeasures, it poses a substantial threat to public health in this region. The pathophysiological mechanisms underlying the severity of the disease are poorly known because Lassa virus (LASV), its causative agent, has to be handled in BSL-4 laboratories and access to clinical samples is difficult. The control of Lassa fever is associated with a rapid and well-balanced immune response and viral clearance. However, severe disease is characterized by uncontrolled i
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Izekor, O. B., A. I. Kenneth, and G. F. Koledoye. "The Mythical Construction of the Spread of Lassa Fever among Garri Marketers: Empirical Evidence from Edo State, Nigeria." Asian Journal of Science and Applied Technology 13, no. 1 (2024): 1–4. http://dx.doi.org/10.70112/ajsat-2024.13.1.4077.

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Lassa fever (LF) is prevalent in Edo State, where garri, the most important cassava product, is processed and marketed. The disease spreads through practices influenced by the beliefs and traditions of garri marketers. The study examines the mythical beliefs people hold about Lassa fever. A simple random sampling procedure was used to select 192 garri marketers. A structured interview schedule was employed to elicit quantitative data, while in-depth interviews were conducted to collect qualitative data. Gross Margin was used to determine profitability, and the qualitative data were transcribed
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Izekor, O. B., A. I. Kenneth, and G. F. Koledoye. "The Mythical Construction of the Spread of Lassa Fever among Garri Marketers: Empirical Evidence from Edo State, Nigeria." Asian Journal of Science and Applied Technology 13, no. 1 (2024): 1–4. http://dx.doi.org/10.51983/ajsat-2024.13.1.4077.

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Lassa fever (LF) is prevalent in Edo State, where garri, the most important cassava product, is processed and marketed. The disease spreads through practices influenced by the beliefs and traditions of garri marketers. The study examines the mythical beliefs people hold about Lassa fever. A simple random sampling procedure was used to select 192 garri marketers. A structured interview schedule was employed to elicit quantitative data, while in-depth interviews were conducted to collect qualitative data. Gross Margin was used to determine profitability, and the qualitative data were transcribed
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28

Dwalu, Emmanuel, Hannock Tweya, Mher Beglaryan, et al. "Epidemiological characteristics and hospital outcomes of hospitalized Lassa fever cases during the 2022-2023 outbreak in Liberia." F1000Research 13 (June 19, 2024): 661. http://dx.doi.org/10.12688/f1000research.150743.1.

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Background Lassa fever is an endemic and immediately notifiable disease in Liberia, and one laboratory confirmed case constitutes an outbreak. We described the epidemiological characteristics and hospital outcome of Lassa fever cases hospitalized during the 2022-2023 outbreak in Liberia. Methods A cohort study was conducted using routine Lassa fever surveillance data from the 2022-2023 outbreak in Liberia. Descriptive statistics were used to summarize the data and log binomial regression to assess the association between epidemiological characteristics and mortality. Results A total of 439 sus
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ter Meulen, J., K. Koulemou, T. Wittekindt, et al. "Detection of Lassa Virus Antinucleoprotein Immunoglobulin G (IgG) and IgM Antibodies by a Simple Recombinant Immunoblot Assay for Field Use." Journal of Clinical Microbiology 36, no. 11 (1998): 3143–48. http://dx.doi.org/10.1128/jcm.36.11.3143-3148.1998.

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The nucleoprotein of Lassa virus, strain Josiah, was expressed inEscherichia coli as an N-terminally truncated, histidine-tagged recombinant protein. Following affinity purification the protein was completely denatured and spotted onto nitrocellulose membrane. A total of 1 μg of protein was applied for detection of Lassa virus antibodies (LVA) in a simple immunoblot assay. Specific anti-Lassa immunoglobulin M (IgM) antibodies could be detected by increasing the amount of protein to 5 μg. A panel of 913 serum specimens from regions in which Lassa virus was endemic and from regions in which Lass
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Osho P. Olanrewaju, Osho E. Omosalewa, Lawrence Okoro, and Ojo-Rowland Olawale. "Co-epidemics: implications of COVID-19 outbreak associated with human immune-deficiency virus, tuberculosis and Lassa fever in a low resource economy-a call for proactive measures." International Journal Of Community Medicine And Public Health 10, no. 2 (2023): 824–32. http://dx.doi.org/10.18203/2394-6040.ijcmph20230246.

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As the global struggle to combat the quadruple burden of COVID-19, human immunodeficiency virus, tuberculosis and Lassa fever continues to increase, Sub-Saharan Africa has been the most affected region, especially Nigeria. There is a close interaction between these four diseases and a clear understanding of each of these diseases is very crucial. People living with chronic medical conditions such as HIV, TB and Lassa fever are more likely to experience poor outcomes from COVID-19 even though there are still some unknown facts as regards the burden of COVID-19 on patients with TB, Lassa fever a
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Chiosi, John, Jeffrey Shaffer, and John Schieffelin. "965. Applying Clinical Prediction Tools to Patients with Lassa Fever." Open Forum Infectious Diseases 5, suppl_1 (2018): S35. http://dx.doi.org/10.1093/ofid/ofy209.081.

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Abstract Background Clinical prediction tools such as the Quick Sequential Organ Failure Assessment (qSOFA) and the Modified Early Warning Score (MEWS) have been used to predict mortality from sepsis in high-income countries, but their application to low- and middle-income countries have been limited. Lassa fever is a viral hemorrhagic fever endemic to West Africa with a case fatality ratio for hospitalized patients of up to 69%. The purpose of this study was to evaluate existing clinical prediction tools for critical illness in predicting adverse outcomes in patients with Lassa fever. Methods
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Hugonnet, S., Hugo Sax, and D. Pittet. "Management of viral haemorrhagic fevers in Switzerland." Eurosurveillance 7, no. 3 (2002): 42–44. http://dx.doi.org/10.2807/esm.07.03.00340-en.

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Over the past years, there have been very few imported cases of VHF in Switzerland: one confirmed and four suspected cases of Ebola fever in Basel in 1994, two suspected cases of Ebola and Lassa fevers in Lausanne in 2000, and in the same year, six suspected cases of Lassa fever in Geneva. Given the considerable diversity in the management of patients with suspected or confirmed VHF, national guidelines are needed, as well as the establishment of a national reference centre.
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Olowookere, S. A., C. A. Adegbenro, A. Idowu, et al. "Knowledge Attitude and Practices Toward Lassa Fever Control and Prevention Among Residents of Ile-Ife, Southwest Nigeria." International Quarterly of Community Health Education 37, no. 2 (2017): 107–12. http://dx.doi.org/10.1177/0272684x17701261.

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Lassa fever had been reported as a cause of death especially in endemic parts of Nigeria. This study assessed the knowledge, attitude, and practices toward Lassa fever control and prevention among residents of Ile-Ife, southwest Nigeria. Descriptive cross-sectional study was conducted among consenting randomly selected adults using an interviewer administered questionnaire. Data were analyzed using descriptive and inferential statistics. A total of 400 questionnaires with completed data were analyzed (response rate 96%). Majority, 207 (51.8%), were males while 193 (48.2%) were females. Most, 2
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Alenoghena, I. "Profile of Confirmed Cases during Lassa fever Outbreak in Etsako West Local Government Area, Edo State." Journal of Medicine and Biomedical Research 22, no. 2 (2024): 54–60. http://dx.doi.org/10.4314/jmbr.v22i2.8.

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Background: Lassa fever (LF) is an acute viral haemorraghic fever caused by the Lassa virus. The objective of this study was to describe the profile of confirmed cases of Lassa fever during an outbreak in Etsako West Local Government Area, Edo State.&#x0D; Methods: A descriptive review of records of cases of Lassa fever between 1st of January to 4th of March, 2019 was done. Confirmation of cases was done using reverse transcriptase polymerase chain reaction. Data analysis was by Statistical Package for Social Science (SPSS) version 20 and descriptive statistics was done.&#x0D; Results: Out of
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Umoke, MaryJoy, Prince Christian Ifeanachor Umoke, Chioma Adaora Nwalieji, et al. "Assessment of Knowledge and Sources of Information on Lassa Fever Infection Among the Undergraduate Students of Ebonyi State University, Nigeria." SAGE Open 11, no. 1 (2021): 215824402110063. http://dx.doi.org/10.1177/21582440211006382.

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Lassa fever is a zoonotic disease characterized by acute viral hemorrhagic fever, endemic in West Africa including Nigeria. The study assessed the knowledge and sources of information on Lassa fever infection among the undergraduate students of Ebonyi State University, Nigeria. This was a descriptive cross-sectional survey conducted among a sample of 389 students (18 years above). A self-administered questionnaire was used to collect data. Data were analyzed with SPSS (Version 20), and hypotheses were tested at p &lt; .05 level of significance. Results showed that the majority of the students
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Dalhat, Mahmood M., Adebola Olayinka, Martin M. Meremikwu, et al. "Epidemiological trends of Lassa fever in Nigeria, 2018–2021." PLOS ONE 17, no. 12 (2022): e0279467. http://dx.doi.org/10.1371/journal.pone.0279467.

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Background Lassa fever is a viral haemorrhagic fever endemic in Nigeria. Improved surveillance and testing capacity have revealed in an increased number of reported cases and apparent geographic spread of Lassa fever in Nigeria. We described the recent four-year trend of Lassa fever in Nigeria to improve understanding of its epidemiology and inform the design of appropriate interventions. Methods We analysed the national surveillance data on Lassa fever maintained by the Nigeria Centre for Diseases Control (NCDC) and described trends, sociodemographic, geographic distribution, and clinical out
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Akafa, Tensaba Andes, Artu Ishishen John, Gloria Omonefe Oladele, and Isaac John Umaru. "Persistent Threat of Lassa Fever in Nigeria: Epidemiology, Challenges, and Strategies for Effective Management." African Journal of Medicine, Surgery and Public Health Research 2, no. 2 (2025): 270–81. https://doi.org/10.58578/ajmsphr.v2i2.5517.

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Lassa fever is a viral hemorrhagic disease that poses a significant public health threat in Nigeria and West Africa. This review assesses the epidemiological trends, health impacts, and socioeconomic consequences of Lassa fever in Nigeria while proposing strategies for effective management and prevention. The natural reservoir of the Lassa virus, the multimammate rat (Mastomys natalensis), is prevalent in Nigerian households, facilitating transmission through direct contact with the rodents or their excreta, which often contaminates food. Consumption of these rats as a delicacy further exacerb
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Fisher-Hoch, S. P., L. Hutwagner, B. Brown, and J. B. McCormick. "Effective Vaccine for Lassa Fever." Journal of Virology 74, no. 15 (2000): 6777–83. http://dx.doi.org/10.1128/jvi.74.15.6777-6783.2000.

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ABSTRACT Lassa fever has been estimated to cause 5,000 deaths annually in West Africa. Recently, war in the zone where Lassa fever is hyperendemic has severely impeded control and treatment. Vaccination is the most viable control measure. There is no correlation between antibody levels and outcome in human patients, and inactivated vaccines produce high titers of antibodies to all viral proteins but do not prevent virus replication and death in nonhuman primates. Accordingly, we vaccinated 44 macaques with vaccinia virus-expressed Lassa virus structural proteins separately and in combination,
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Grace, John-Ugwuanya A., Ifunanya J. Egoh, and Nnenna Udensi. "Epidemiological trends of Lassa fever in Nigeria from 2015-2021: A review." Therapeutic Advances in Infectious Disease 8 (January 2021): 204993612110582. http://dx.doi.org/10.1177/20499361211058252.

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Introduction: Lassa fever is a viral haemorrhagic fever with non-specific symptoms that has shown an upward trend in Nigeria and other West African countries, which is depicted by high incidence and case fatality in recent years. There are different reports on the yearly case burden of Lassa fever from the Federal Ministry of Health in Nigeria, through the regulatory body – Nigeria Centre for Disease Control (NCDC). Being the epicentre of the disease, Lassa fever has been exported from Nigeria to both neighbouring and distant countries.Methods: The aim of this review was to carry out a retrosp
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Raabe, Vanessa, and Jeffrey Koehler. "Laboratory Diagnosis of Lassa Fever." Journal of Clinical Microbiology 55, no. 6 (2017): 1629–37. http://dx.doi.org/10.1128/jcm.00170-17.

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ABSTRACTLassa virus remains an important cause of illness in West Africa and among the travelers returning from this region with an acute febrile illness. The symptoms of Lassa fever can be nonspecific and mimic those of other endemic infections, especially early in illness, making a clinical diagnosis difficult; therefore, laboratory testing is needed to confirm the diagnosis. An early identification of Lassa fever is crucial for maximizing the benefit of available antiviral therapy, as treatment efficacy rapidly decreases following the clinical onset of the disease. This minireview provides
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Kunz, Stefan. "The role of the vascular endothelium in arenavirus haemorrhagic fevers." Thrombosis and Haemostasis 102, no. 12 (2009): 1024–29. http://dx.doi.org/10.1160/th09-06-0357.

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SummaryViral haemorrhagic fevers (VHF) caused by arenaviruses are among the most devastating emerging human diseases.The most important pathogen among the arenaviruses is Lassa virus (LASV), the causative agent of Lassa fever that is endemic to West Africa. On the South American continent, the New World arenavirus Junin virus (JUNV), Machupo (MACV), Guanarito (GTOV), and Sabia virus (SABV) have emerged as causative agents of severe VHFs. Clinical and experimental studies on arenavirus VHF have revealed a crucial role of the endothelium in their pathogenesis. However, in contrast to other VHFs,
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Denwigwe, Chiaka Patience, and Maria E. Ngwu. "Personal variables and attitude of youths to Lassa fever preventive practices in Bwari area Council Abuja, Nigeria: Counselling implications." Global Journal of Educational Research 21, no. 1 (2022): 17–25. http://dx.doi.org/10.4314/gjedr.v21i1.3.

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The study investigated the influence of personal variables on the attitude of Youths in Bwari Area Council Abuja, Nigeria to Lassa fever preventive practices. The study used the descriptive survey design. Using the snowball sampling technique proposed by Jones (1997) and used by Denwigwe and Ezekwe (2017), a sample of 200 youths was selected from the study area. Four hypotheses were formulated for the study and tested at 0.05 level of significance. A researcher-made questionnaire known as the personal variables and attitude to Lassa fever preventive practices questionnaire (PVALPPQ) was used a
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Ilori, Adetunji, Adeyeye Awogbemi, Adebisi Michael, Toyosi Adebambo, Kole Emmanuel, and Dayo Kayode. "Effects of Early Treatment of Lassa Fever and Symptoms in Nigeria." International Journal of Biomedical Materials Research 13, no. 1 (2025): 1–9. https://doi.org/10.11648/j.ijbmr.20251301.11.

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Lassa fever is an acute viral disease characterized by a broad range of clinical symptoms. This study presents a comprehensive analysis of Lassa fever cases in Nigeria, focusing on demographic patterns, symptomatology, geographic distribution, and factors influencing outcomes of patients. Using secondary data collected from the Nigeria Centre for Disease Control (NCDC) from 2018 to 2021, Geographically, Edo and Ondo States accounted for the majority of cases, contributing 49.1% and 23.6% of recoveries, respectively, highlighting the regional concentration of Lassa fever burden. Factor analysis
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Onah, Ifeanyi Sunday, and Obiora Cornelius Collins. "Dynamical System Analysis of a Lassa Fever Model with Varying Socioeconomic Classes." Journal of Applied Mathematics 2020 (November 18, 2020): 1–12. http://dx.doi.org/10.1155/2020/2601706.

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Lassa fever is an animal-borne acute viral illness caused by Lassa virus. It poses a serious health challenge around the world today, especially in West African countries like Ghana, Benin, Guinea, Liberia, Mali, Sierra Leone, and Nigeria. In this work, we formulate a multiple-patch Lassa fever model, where each patch denotes a socioeconomic class (SEC). Some of the important epidemiological features such as basic reproduction number of the model were determined and analysed accordingly. We further investigated how varying SECs affect the transmission dynamics of Lassa fever. We analysed the r
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Francis, Bright Chukwudi. "Lassa fever situation report for week 1 to week 15 from 2021 to 2023 in Nigeria: a review." Journal of Health, Applied Sciences and Management 6, no. 3 (2023): 134–38. http://dx.doi.org/10.4314/johasam.v6i3.16.

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Lassa fever is a viral hemorrhagic fever caused by Lassa virus. The Lassa virus is an enveloped single-stranded, non-lytic bi-segmented negative-stranded RNA virus belonging to the family Arenaviridae. Lassa fever is relatively common or endemic in West Africa or particularly in countries such as Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, and Nigeria. Humans usually become infected with the virus through exposure to food or household items contaminated with the urine or faeces of infected multimammate rat while spread of the disease between or among persons is by direct contact. The di
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Liman, Yakubu Attahiru, and Faima Ishay. "Scourge of Lassa fever pandemic in Nigeria: The roles of library and information professionals in mitigating the spread of the disease." Library and Information Perspectives and Research 5, no. 3 (2023): 149–56. http://dx.doi.org/10.47524/lipr.v5i3.150.

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The paper explored the Lassa fever pandemic which is currently the most deadly disease ravaging most part of Nigeria. While it is disturbing that adequate environmental cautions were not been taken to inhibit its seasonal outbreak, it is more worried that 54 years after discovery of Lassa fever disease in Nigeria, stakeholders have failed to produce vaccines against the disease making it the worst in the history of the country. The disease has also spread rapidly in some part of West African countries. Literatures revealed that in the first quarter of 2023, Lassa fever have killed 203 persons
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Roberts, Leslie. "A spiking fever." Science 383, no. 6685 (2024): 810–16. http://dx.doi.org/10.1126/science.ado7079.

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Wiwanitkit, Viroj. "Lassa viral hemorrhagic fever." Medical Journal of Dr. D.Y. Patil Vidyapeeth 13, no. 1 (2020): 28. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_144_19.

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Yun, Nadezhda E., and David H. Walker. "Pathogenesis of Lassa Fever." Viruses 4, no. 10 (2012): 2031–48. http://dx.doi.org/10.3390/v4102031.

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Glover, S. C., and SusanP Fisher-Hoch. "MANAGEMENT OF LASSA FEVER." Lancet 326, no. 8468 (1985): 1359. http://dx.doi.org/10.1016/s0140-6736(85)92651-0.

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