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Dissertations / Theses on the topic 'Latent membrane protein one'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Patsos, Georgios. "Epstein-Barr virus latent membrane protein 2A." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399923.

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2

Chen, Fu. "Epstein-Barr virus (EBV) latent membrane protein LMP2A /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-589-5/.

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3

Johansson, Pegah. "Regulation of the Epstein-Barr virus latent membrane protein 1 expression /." Göteborg : Göteborg University, Institute of Biomedicine, Dept. of Clinical Chemistry and Transfusion Medicine, 2007. http://hdl.handle.net/2077/8509.

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4

Lin, San-san, and 林新新. "Mechanism of Epstein-Barr virus latent membrane protein 1-regulated cytokine expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30152033.

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5

Marshall, Neil A. "The role of EBV latent membrane protein 1 induced regulatory T-cells in latent infection and Hodgkin lymphoma." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430397.

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Healthy EBV seropositive donors tested for the ability to mount Th responses against LMP1 responded with secretion of high levels of the immunosuppressive cytokine IL-10 which was secreted from cells phenotypically analogous to the Tr1 class of regulatory T-cells. The epitopes inducing this IL-10 secretion were clustered in the hydrophobic, transmembrane half of the protein that corresponded to a cluster of high affinity MHC class II binding domains. Since the LMP1 induced TO cells could effectively suppress immune responses in an IL- 10 dependent manner, it seems likely that the induction o

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6

Liu, Yu, and 劉鈺. "Biological properties of EBV-encoded latent membrane protein 1 in nasopharyngeal epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31242078.

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7

McLean, Adele. "An investigation into the early stages of latent membrane protein 1 induced carcinogenesis." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437951.

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8

Curran, John Andrew. "The oncogenic activity of the latent membrane protein of EBV in transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388552.

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9

Vaysberg, Maria. "Characterization of latent membrane protein 1 induced signal transduction in B cell lymphomas /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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10

Liu, Yu. "Biological properties of EBV-encoded latent membrane protein 1 in nasopharyngeal epithelial cells /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23001008.

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11

Li, Hoi-ming, and 李海明. "Functional studies of Epstein-Barr virus latent membrane protein 1 in nasopharyngeal epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29503085.

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12

Faucher, Sylvie. "Cyno-EBV, a cynomolgus monkey EBV-like virus, and its latent membrane protein 1 oncogene." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6109.

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Epstein-Barr virus (EBV) and its oncogene, the latent membrane protein 1 (LMP1), are associated with many human malignancies. Likewise, EBV-like viruses have been associated with lymphomas in immunosuppressed cynomolgus monkeys. This study characterizes the biology of Cyno-EBV, a cynomolgus monkey EBV-like virus, including the structural proteins, antigenic relatedness to EBV and molecular and functional analysis of its LMP1 homologue. Cyno-EBV infection is ubiquitous in its host species. In vitro , Cyno-EBV immortalized cynomolgus monkey but not human B cells. The electrophoretic profile of C

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13

Wan, Jun. "Elucidation of the JNK pathway mediated by Epstein-Barr virus encoded latent membrane protein 1 /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20WAN.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 105-128). Also available in electronic version. Access restricted to campus users.

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14

Tsang, Wai-hung. "The transcription regulation of Epstein-Barr virus latent membrane protein gene in nasopharyngeal carcinoma cell line /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21185566.

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15

Wu, Liming. "Elucidation of the NF-kB pathway mediated by Epstein - Barr virus-encoded latent membrane protein 1 (LMP1) /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20WU.

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16

Tsang, Wai-hung, and 曾偉雄. "The transcription regulation of Epstein-Barr virus latent membrane protein gene in nasopharyngeal carcinoma cell line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221774.

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17

Jia, Junying. "The role of latent membrane protein 2 in the pathogenesis of Epstein-Barr virus associated malignancy." Thesis, University of Wolverhampton, 2006. http://hdl.handle.net/2436/88495.

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18

Blake, Sarah Madeline Stares. "An investigation of the signalling pathways activated by Epstein-Barr virus-encoded latent membrane protein 1." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394163.

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19

Morris, Mhairi Anne. "An investigation into the function of the EBV-encoded latent membrane protein (LMP1) in nasopharyngeal carcinoma (NPC)." Thesis, University of Birmingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532297.

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Approximately 15-20% of global cancer incidence is causally linked to viral infection. Although a number of these viruses are implicated in the aetiology of lymphomas or leukaemias, the vast majority are associated with malignancies of epithelial cells. In epithelial tissues, several classes of proteins are involved in maintaining tissue architecture, including those that promote cell-cell adhesion and others which mediate cell-matrix interactions. Previous studies have shown that the EBV-encoded oncogene, latent membrane protein-l (LMPl), altered the morphology of SCC12F cells in vitro, downr

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20

Ye, Weihua. "One key to two doors : Dual targeting peptides and membrane mimetics." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-116817.

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A targeting peptide at the N-terminus of a precursor protein usually directs the protein synthesized in the cytosol to a specific organelle in the cell. Interestingly, some targeting peptides, so-called dual targeting peptides (dTPs) can target their protein to both mitochondria and chloroplasts. In order to understand the mechanism of dual targeting, a dTP from threonyl tRNA synthetase (ThrRS-dTP) was investigated as a model dTP in this thesis work. The results suggest that ThrRS-dTP is intrinsically disordered in solution but has an α-helical propensity at the N-terminal part. Tom20 and Toc3

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21

Yang, Xinhai, and 楊新海. "Latent membrane protein 1 of Epstein-barr virus induces cell proliferation and participates in the inhibition of replicativesenescence." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241256.

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22

George, Juliet Helen. "Studies on the effects of Epstein-Barr virus-encoded latent membrane protein 2 (LMP2) on human epithelial cells." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393819.

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23

Macdiarmid, Jennifer. "The role of the latent membrane protein 1 of Epstein-Barr virus in the genesis of nasopharyngeal carcinoma." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394961.

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24

Böhm, Daniela [Verfasser]. "Investigation of the mechanism of Epstein-Barr virus Latent Membrane Protein 1 mediated NF-kB activation / Daniela Böhm." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/102450249X/34.

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25

Ardila-Osorio, Héctor. "Étude de la contribution des complexes riches en glycolipides et en cholestérol à l'activité biologique d'une oncoprotéine du virus d'Epstein-Barr : la LMP1 (Latent Membrane Protein 1)." Paris 6, 2001. http://www.theses.fr/2001PA066387.

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26

Wang, Ling, Yujia Wang, Juan Zhao та ін. "The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6529.

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Recently, linear ubiquitin assembly complex (LUBAC)-mediated linear ubiquitination has come into focus due to its emerging role in activation of NF-κB in different biological contexts. However, the role of LUBAC in LMP1 signaling leading to NF-κB and interferon regulatory factor 7 (IRF7) activation has not been investigated. We show here that RNF31, the key component of LUBAC, interacts with LMP1 and IRF7 in Epstein-Barr virus (EBV)-transformed cells and that LUBAC stimulates linear ubiquitination of NEMO and IRF7. Consequently, LUBAC is required for LMP1 signaling to full activation of NF-κB

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27

Zamzami, Omar M. "Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1) peptides as inducers of regulatory cells to treat autoimmune haemolytic anaemia." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until May, 2014, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=59565.

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28

Zhang, Xiangning. "Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1): implications for nasopharyngeal carcinoma /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-405-8/.

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29

黃麗敏 and Lai-man Wong. "A study of the biological effect of Epstein-Barr virus encoded latent membrane protein 1 (LMP1) in human epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221932.

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30

Wong, Lai-man. "A study of the biological effect of Epstein-Barr virus encoded latent membrane protein 1 (LMP1) in human epithelial cells /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2130113X.

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31

Li, Pui-yue. "The roles of latent membrane protein 1 of Epstein-Barr virus in cell growth, proliferation and survival in a rat fibroblast cell line /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2084329X.

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32

李佩瑜 and Pui-yue Li. "The roles of latent membrane protein 1 of Epstein-Barr virus in cell growth, proliferation and survival in a rat fibroblast cell line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221385.

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33

Glasier, Mary-Ann M. "A role for SHP-1 and Vav in the abrogation of B cell receptor signal transduction by latent membrane protein 2 (LMP2)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29258.pdf.

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34

Gao, Xiao. "The role of oxidative stress and chitinase like proteins in Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenesis." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7855/.

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Latent membrane protein 1 (LMP1) is regarded as the primary Epstein-Barr virus (EBV) oncogene, and is expressed in several EBV associated malignancies, including BL, HD and NPC. In order to understand the role of LMP1 in EBV associated epithelial malignancies, our lab generated transgenic mice expressing LMP1 in the epidermis. This mice display an age progressive inflammatory phenotype in the skin, progress to carcinogenesis. In order to investigate the rold of reactive oxygen species (ROS) in the phenotype, mice were treated with the antioxidant N-acetyl-L-cysteine (NAC). The treatment inhibi

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35

Arcipowski, Kelly Marie. "Molecular mechanisms of TRAF6 function in signaling pathways of the oncogenic viral mimic of CD40, LMP1." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3560.

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Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays important roles in EBV-mediated B cell transformation, development of EBV-associated malignancies, and exacerbation of certain autoimmune conditions. LMP1 functionally mimics tumor necrosis factor receptor (TNFR) superfamily member CD40, but LMP1 signals are amplified and sustained compared to those induced by CD40. CD40 and LMP1 rely on TNFR-associated factors (TRAFs) to mediate signaling, but use TRAFs differently. TRAF6 is important for CD40 signaling, and was implicated in LMP1 signaling in non-B cells. Here, we addres

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36

Forrester, Megan Amy. "Identification of interleukin-10 producing cells specific for Epstein-Barr virus latent membrane protein 1 and the involvement of interleukin-27 in their induction." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167956.

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During latent Epstein-Barr virus (EBV) infection, the T helper cell response to the EBV latent membrane protein (LMP)1 is dominated by the production of IL-10, but by IFN- γ during acute EBV infection. The purpose of this thesis was to develop methods for the enumeration and characterisation of the IL-10 producing CD4+ T cells that respond to peptides of the EBV protein LMP1, and to investigate the possible involvement of IL-27 in the development of these cells. It was found that some human donors have very high concentrations of IL-27 within serum, which is not dependent on EBV infection stat

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37

Sterz, Kai Raphael [Verfasser], Arnd [Akademischer Betreuer] Kieser, and Bernhard [Akademischer Betreuer] Küster. "A Systematical Analysis of the Signal Transduction Pathways Induced by the Latent Membrane Protein 1 (LMP1) of Epstein-Barr Virus / Kai Raphael Sterz. Gutachter: Bernhard Küster ; Arnd Kieser. Betreuer: Arnd Kieser." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1061125955/34.

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38

Ouk, Tan-Sothéa. "Rôle de la protéine LMP1 dans la balance survie/apoptose des cellules infectées par le virus d'Epstein-Barr." Limoges, 2008. https://aurore.unilim.fr/theses/nxfile/default/e0773f8b-990b-46fb-983c-9e953f8732d5/blobholder:0/2008LIMO4028.pdf.

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Le virus d’Epstein-Barr (EBV) est un herpèsvirus humain qui infecte 90% de la population, mais l’infection est, le plus souvent, asymptomatique. Après infection, le virus établit une latence virale caractérisée par l’expression restreinte de gènes viraux, appelés gènes de latence permettant au virus de persister tout au long de la vie. On définit trois latences virales (I, II et III) selon le profil d’expression des gènes de latence codant les antigènes EBNAs (-1, -2, -3 et -LP) et les protéines membranaires LMPs (-1 et -2). L��immortalisation in vitro des lymphocytes B aboutit à des lignées

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39

Brocqueville, Guillaume. "Dualité fonctionnelle de LMP1 : implication dans l'apoptose et la transformation cellulaire." Phd thesis, Université du Droit et de la Santé - Lille II, 2011. http://tel.archives-ouvertes.fr/tel-00769919.

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Le virus d'Epstein-Barr (EBV) est un herpèsvirus humain qui infecte plus de 90% de la population généralement de façon bénigne et asymptomatique. Cependant, de nombreuses données démontrent que ce virus peut également contribuer à certains processus de cancérisation. En effet, l'EBV est associé à de nombreuses pathologies malignes telles que le lymphome de Burkitt, le lymphome hodgkinien et le carcinome du nasopharynx. Dans la grande majorité de ces cancers associées à ce virus, l'EBV exprime un programme de latence de type II durant lequel la protéine LMP1 est exprimée. Elle est décrite comme

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40

Brocqueville, Guillaume. "Dualité fonctionnelle de LMP1 : implication dans l’apoptose et la transformation cellulaire." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S030/document.

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Le virus d’Epstein-Barr (EBV) est un herpèsvirus humain qui infecte plus de 90% de la population généralement de façon bénigne et asymptomatique. Cependant, de nombreuses données démontrent que ce virus peut également contribuer à certains processus de cancérisation. En effet, l’EBV est associé à de nombreuses pathologies malignes telles que le lymphome de Burkitt, le lymphome hodgkinien et le carcinome du nasopharynx. Dans la grande majorité de ces cancers associées à ce virus, l’EBV exprime un programme de latence de type II durant lequel la protéine LMP1 est exprimée. Elle est décrite comme

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41

Faumont, Nathalie. "Implication du virus d'Epstein-Barr dans la maladie de Hodgkin-classique : rôle du polymorphisme du gène viral LMP-1-BNLF1 sur les propriétés oncogéniques de la protéine LMP-1." Toulouse 3, 2003. http://www.theses.fr/2003TOU30228.

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42

Chiou, Che-Hao, and 邱哲豪. "Studies on Canine Tumor-derived Latent Membrane Protein 1." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/18542784959683904813.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>99<br>Epstein-Barr virus (EBV) is widespread in the human population and has been associated with multiple human malignancies. Previously, we and others reported the presence of EBV or EBV-related viral signals in pet dogs. However, whether EBV may be associated with canine tumors is still unknown. In this study, we cloned cDNA of EBV latent membrane protein 1 (LMP1) from an EBV-positive canine tumor sample and investigated its influence on EBV negative cells. In addition, we compared the LMP1 sequence of this canine tumor variant with that of B95-8 strain. The

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43

Chen, Pei Chen, and 陳珮琛. "The transrepression function of EBV latent membrane protein 1." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/76753010987434521969.

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44

Li, Rui-Nian, and 李瑞年. "FUNCTIONAL ANALYSIS OF LATENT MEMBRANE PROTEIN 1 OF EPSTEIN－BARR VIRUS." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/63154765323679795733.

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45

Wang, Chun-Ju, and 王濬儒. "Regulation of IFP35 by Epstein-Barr Virus Latent Membrane Protein 1." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/00990560785182068492.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>97<br>Interferon-induced proteins (IFPs) contribute a wild spectrum of IFN’s function, including suppression of virus replication, induction of MHC class II expression in antigen presenting cells, and activation of macrophages, dentritic cells and NK cells. However, the roles of IFN-independent IFP induction in many tumor cells are not fully characterized. Epstin-Barr virus (EBV) is an oncogenic gamma-herpesvirus that persistently infects over 95% of the human population. One of the strong oncognic potencies for EBV is its ability to immortalize human B cells into ly

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46

劉武明. "The Transrepression and Transactivation Functions of EBV Latent Membrane protein 1." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/88739314019894596412.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>85<br>Epstein-Barr virus (EBV) is an enveloped herpes virus which contains a linear double-stranded DNA. After infects cells, it usually establishes latency in the cells. EBV has been reported to be associated with many diseases, including T-cell lymphoma, Burkitt''s lymphoma, chronic fatigue syndrome, lymphoepithelioma, rheumatoid arthritis, and nasopharyngeal carcinoma (NPC) etc. . Since NPC is one of the ten leading cancers in Taiwan, the elucidation of its mechanism in causing the disease thus becomes very important. The Epstein-Barr virus (EBV) latent inf

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47

Chen, Ming-jhe, and 陳明哲. "A Functional Study on Canine Tumor Variants of Latent Membrane Protein 1." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/awnzwx.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>101<br>Epstein-Barr virus (EBV) has been infecting more than 90% of the world''s adult population. It is a gammaherpesvirus that is associated with multiple malignancies. In a previous study, we first discovered EBV infection in pet dogs. Other teams later confirmed the presence of Epstein-Barr virus signal in pet dogs. Recently, we and other group found herpes virus-like particles in canine tumors. In addition, we detected EBV-specific BamHI W sequence and, gene expressions of latent membrane protein 1 (LMP1) in several EBV positive canine tumors. In

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48

Yeh, Te-Shien, and 葉德賢. "Functional study of truncated latent membrane protein-1 of epstein-barr virus." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/17058907573843308264.

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49

huang, Zoo-Hzu, and 黃如玉. "Expression of the Epstein-Barr virus latent membrane protein 1 in human placenta." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/44974093237376983348.

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碩士<br>國立中山大學<br>生物科學系研究所<br>90<br>In normal pregnant women, reactivation of Epstein-Barr virus (EBV) frequently occurs. Cellular immune response is apparently supperessed, but the antibodies cross the placenta and protect the infant against primary infection for many months. The Epstein—Barr virus (EBV) encoded latent membrane protein 1 (LMP1) which plays a crucial role in the long-term persistence of this virus within the cells of the immune system. Not only is this protein critical for the transformation of resting B cells by EBV, it also displays pleiotropic effects on various cellular prot

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50

陳秀玲. "Differentially Expressed Proteins in Epstein - Barr virus latent membrane protein 1-expressing cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/20545749487069411275.

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碩士<br>長庚大學<br>基礎醫學研究所<br>92<br>Latent membrane protein 1(LMP-1), an oncogene of Epstein-Barr virus (EBV), can induce transformation of cells. Since the entry of cell cycle is controlled by G1 to S phase, which is regulated by expression level of cyclin D1. Several reports showed that over-expression of cyclin D1 was found in nasopharyngeal carcinoma (NPC) tissues. Besides, cyclin D1 is regulated by p52 transcriptional factor, which is the downstream signaling mediator of no canonical NF-B signaling pathway. LMP1 promoted the p100 to p52 processing via its C-terminus CTAR1 domain. However, the

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