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Journal articles on the topic 'Latent membrane protein one'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhang, Yujiao, Yinzhong Shen, Lin Yin, et al. "Plasma Membrane Proteomic Profile Discovers Macrophage-capping Protein Related to Latent HIV-1." Current HIV Research 17, no. 1 (2019): 42–52. http://dx.doi.org/10.2174/1570162x17666190506155222.

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Background:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely.Objective:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines.Method:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 cells, A7 cells) and its parental cell line (Jurkat cells) were used. The plasma membrane (PM) fraction from cultured cells was enriched through aqueous two-phase partition. PM proteins were extracted and then separated using two-dimensional electrophoresis (2DE). Differentially expres

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Diduk, S. V., K. V. Smirnova, and V. E. Gurtsevitch. "THE INFLUENCE OF POINT MUTATIONS IN THE EPSTEIN-BARR VIRUS LMP1 ONCOGENE ON THE CELL CYTOSKELETON AND ACTIVATION OF INDUCIBLE FORM OF NO SYNTHASE." Annals of the Russian academy of medical sciences 67, no. 3 (2012): 62–67. http://dx.doi.org/10.15690/vramn.v67i3.187.

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One of the latent proteins encoded by the Epstein−Barr virus (EBV), the latent membrane protein 1 (LMP1), plays a key role in developing of EBV-associated human malignancies. Polymorphism of LMP1 protein is its characteristic feature. Some specific mutations in LMP1 genome have previously been detected in different geographic regions, however, the influence of these mutations on functional activity of LMP1 was not still determined. In this study we demonstrated for the first time the significance of individual point mutations among common ones observed in LMP1 and their combination on activati

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Murray, R. J., M. G. Kurilla, J. M. Brooks, et al. "Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies." Journal of Experimental Medicine 176, no. 1 (1992): 157–68. http://dx.doi.org/10.1084/jem.176.1.157.

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Epstein-Barr virus (EBV), a human herpes virus with oncogenic potential, persists in B lymphoid tissues and is controlled by virus-specific cytotoxic T lymphocyte (CTL) surveillance. On reactivation in vitro, these CTLs recognize EBV-transformed lymphoblastoid cell lines (LCLs) in an HLA class I antigen-restricted fashion, but the viral antigens providing target epitopes for such recognition remain largely undefined. Here we have tested EBV-induced polyclonal CTL preparations from 16 virus-immune donors on appropriate fibroblast targets in which the eight EBV latent proteins normally found in

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Liebowitz, D., R. Kopan, E. Fuchs, J. Sample, and E. Kieff. "An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes." Molecular and Cellular Biology 7, no. 7 (1987): 2299–308. http://dx.doi.org/10.1128/mcb.7.7.2299-2308.1987.

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The Epstein-Barr virus (EBV) latent infection membrane protein (LMP) is likely to be an important mediator of EBV-induced cell proliferation, since it is one of the few proteins encoded by the virus in latent infection and since production of this protein in Rat-1 cells results in their conversion to a fully transformed phenotype. LMP was previously noted to localize to patches at the cell periphery. In this paper we examine the basis of LMP patching in EBV-infected, transformed lymphocytes. Our data indicate that LMP is associated with the cytoskeletal protein vimentin. Although LMP is fully

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Liebowitz, D., R. Kopan, E. Fuchs, J. Sample, and E. Kieff. "An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes." Molecular and Cellular Biology 7, no. 7 (1987): 2299–308. http://dx.doi.org/10.1128/mcb.7.7.2299.

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The Epstein-Barr virus (EBV) latent infection membrane protein (LMP) is likely to be an important mediator of EBV-induced cell proliferation, since it is one of the few proteins encoded by the virus in latent infection and since production of this protein in Rat-1 cells results in their conversion to a fully transformed phenotype. LMP was previously noted to localize to patches at the cell periphery. In this paper we examine the basis of LMP patching in EBV-infected, transformed lymphocytes. Our data indicate that LMP is associated with the cytoskeletal protein vimentin. Although LMP is fully

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Engels, Niklas, Mark Merchant, Rajita Pappu, Andrew C. Chan, Richard Longnecker, and Jürgen Wienands. "Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module." Journal of Experimental Medicine 194, no. 3 (2001): 255–64. http://dx.doi.org/10.1084/jem.194.3.255.

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In latently infected B lymphocytes, the Epstein-Barr virus (EBV) suppresses signal transduction from the antigen receptor through expression of the integral latent membrane protein 2A (LMP2A). At the same time, LMP2A triggers B cell survival by a yet uncharacterized maintenance signal that is normally provided by the antigen receptor. The molecular mechanisms are unknown as LMP2A-regulated signaling cascades have not been described so far. Using a novel mouse model we have identified the intracellular adaptor protein Src homology 2 (SH2) domain–containing leukocyte protein (SLP)-65 as a critic

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Kaykas, Ajamete, Kathleen Worringer, and Bill Sugden. "LMP-1's Transmembrane Domains Encode Multiple Functions Required for LMP-1's Efficient Signaling." Journal of Virology 76, no. 22 (2002): 11551–60. http://dx.doi.org/10.1128/jvi.76.22.11551-11560.2002.

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ABSTRACT The latent membrane protein-1 (LMP-1) of Epstein-Barr virus (EBV) contributes to the proliferation of infected B lymphocytes by signaling through its binding to cellular signaling molecules. It apparently mimics members of the tumor necrosis factor receptor family, in particular, CD40, by binding a similar set of cellular molecules as does CD40. LMP-1 differs dramatically in its structure from CD40. LMP-1 has six membrane-spanning domains as opposed to CD40's one. LMP-1 also differs from CD40 in its apparent independence of a ligand for its signaling. We have examined the role of LMP-

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Lee, Song Hee, Katie Caviness, Emily R. Albright, et al. "Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency." Journal of Virology 90, no. 20 (2016): 9483–94. http://dx.doi.org/10.1128/jvi.01547-16.

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ABSTRACTThe UL133–138 locus present in clinical strains of human cytomegalovirus (HCMV) encodes proteins required for latency and reactivation in CD34+hematopoietic progenitor cells and virion maturation in endothelial cells. The encoded proteins form multiple homo- and hetero-interactions and localize within secretory membranes. One of these genes, UL136 gene, is expressed as at least five different protein isoforms with overlapping and unique functions. Here we show that another gene from this locus, the UL138 gene, also generates more than one protein isoform. A long form of UL138 (pUL138-L

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Moskalev, Alexander V., Boris Yu Gumilevsky, Vasiliy Ya Apchel, and Vasiliy N. Tsygan. "The role of viruses in cell transformation and oncogenesis." Bulletin of the Russian Military Medical Academy 25, no. 1 (2023): 133–44. http://dx.doi.org/10.17816/brmma121327.

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The data of modern scientific literature characterizing individual mechanisms of transformation of normal cells and various stages of oncogenesis associated with viruses were analyzed. The data of sequencing of tumor genomes and amino acid sequences indicate that most tumors are a consequence of the accumulation of sequential mutations, a significant contribution to the formation of which was made by oncogenic viruses. Processes that alter or impair the functioning of signaling pathways can contribute to transformation and oncogenesis. The phosphorylation of the ribosomal protein S6 by protein

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Dudziak, Diana, Arnd Kieser, Ulrike Dirmeier та ін. "Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway". Journal of Virology 77, № 15 (2003): 8290–98. http://dx.doi.org/10.1128/jvi.77.15.8290-8298.2003.

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ABSTRACT Epstein-Barr virus (EBV) infects human resting B cells and transforms them in vitro into continuously growing lymphoblastoid cell lines (LCLs). EBV nuclear antigen 2 (EBNA2) is one of the first viral proteins expressed after infection. It is able to transactivate viral as well as cellular target genes by interaction with cellular transcription factors. EBNA2 target genes can be studied easily by using an LCL (ER/EB2-5) in which wild-type EBNA2 is replaced by an estrogen-inducible EBNA2. Since the cell surface molecule CD83, a member of the immunoglobulin superfamily and a marker for m

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Murthy, M. S., and S. V. Pande. "Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes." Biochemical Journal 248, no. 3 (1987): 727–33. http://dx.doi.org/10.1042/bj2480727.

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Recent evidence has shown that the outer, overt, malonyl-CoA-inhibitable carnitine palmitoyltransferase (CPTo) activity resides in the mitochondrial outer membrane [Murthy & Pande (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 378-382]. A comparison of CPTo activity of rat liver mitochondria with the inner, initially latent, carnitine palmitoyltransferase (CPTi) of the mitochondrial inner membrane has revealed that the presence of digitonin and several other detergents inactivates CPTo activity. The CPTi activity, in contrast, was markedly stimulated by various detergents and phospholipid liposo

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Tang, Xiaoli, Huafei Lu, Patrick M. Tarwater, David L. Silverberg, Christoph Schorl та Bharat Ramratnam. "Adeno-Associated Virus (AAV)-Delivered Exosomal TAT and BiTE Molecule CD4-αCD3 Facilitate the Elimination of CD4 T Cells Harboring Latent HIV-1". Microorganisms 12, № 8 (2024): 1707. http://dx.doi.org/10.3390/microorganisms12081707.

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Combinatorial antiretroviral therapy (cART) has transformed HIV infection from a death sentence to a controllable chronic disease, but cannot eliminate the virus. Latent HIV-1 reservoirs are the major obstacles to cure HIV-1 infection. Previously, we engineered exosomal Tat (Exo-Tat) to reactivate latent HIV-1 from the reservoir of resting CD4+ T cells. Here, we present an HIV-1 eradication platform, which uses our previously described Exo-Tat to activate latent virus from resting CD4+ T cells guided by the specific binding domain of CD4 in interleukin 16 (IL16), attached to the N-terminus of

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Babinska, Anna, Michael V. Hogan, Tomasz Sobocki, Malgorzata B. Sobocka, Yigal H. Ehrlich, and Elizabeth Kornecki. "Identification of ecto-PKC on surface of human platelets: role in maintenance of latent fibrinogen receptors." American Journal of Physiology-Heart and Circulatory Physiology 278, no. 6 (2000): H2008—H2019. http://dx.doi.org/10.1152/ajpheart.2000.278.6.h2008.

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Human platelets express a protein phosphorylation system on their surface. A specific protein kinase C (PKC) antibody, monoclonal antibody (MAb) 1.9, which binds to the catalytic domain of PKC and inhibits its activity, causes the aggregation of intact platelets while inhibiting the phosphorylation of platelet surface proteins. Photoaffinity labeling with 100 nM 8-azido-[α32P]ATP identified this ecto-PKC as a single surface protein of 43 kDa sensitive to proteolysis by extracellular 0.0005% trypsin. Inhibition of the binding of 8-azido-[α32P]ATP to the 43-kDa surface protein by MAb 1.9 identif

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Sato, Hitoshi, Lesley Pesnicak, and Jeffrey I. Cohen. "Varicella-Zoster Virus Open Reading Frame 2 Encodes a Membrane Phosphoprotein That Is Dispensable for Viral Replication and for Establishment of Latency." Journal of Virology 76, no. 7 (2002): 3575–78. http://dx.doi.org/10.1128/jvi.76.7.3575-3578.2002.

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ABSTRACT Varicella-zoster virus (VZV) encodes six genes that do not have homologs in herpes simplex virus. One of these genes, VZV open reading frame 2 (ORF2), was expressed as a 31-kDa phosphoprotein in the membranes of infected cells. Unlike equine and bovine herpesvirus type 1 ORF2 homologs that are associated with virions, VZV virions contained no detectable ORF2 protein. The ORF2 deletion mutant established a latent infection in cotton rats at a frequency and with a number of VZV genomes similar to that of the parental virus. ORF63 transcripts, a hallmark of latent infection, were present

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Endo, K., S. Kondo, J. Shackleford, et al. "Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration." Oncogene 28, no. 14 (2009): 1725–35. http://dx.doi.org/10.1038/onc.2009.20.

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Fotheringham, J. A., S. Mazzucca та N. Raab-Traub. "Epstein-Barr virus latent membrane protein-2A-induced ΔNp63α expression is associated with impaired epithelial-cell differentiation". Oncogene 29, № 30 (2010): 4287–96. http://dx.doi.org/10.1038/onc.2010.175.

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Pollock, A. M., M. Toner, M. McMenamin, J. Walker, and C. I. Timon. "Absence of Epstein-Barr virus encoded RNA and latent membrane protein (LMP1) in salivary gland neoplasms." Journal of Laryngology & Otology 113, no. 10 (1999): 906–8. http://dx.doi.org/10.1017/s0022215100145542.

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AbstractA series of 55 (42 benign and 13 malignant) salivary gland tumours were investigated by immunohistochemistry, to detect Epstein-Barr virus (EBV) latent membrane protein (LMP1) and byin situhybridization for EBV-encoded RNA. Non-neoplastic gland from all the patients with tumours and 15 control glands were also examined. All cases, both neoplastic and non-neoplastic were negative for LMP1 and failed to show any positive signal byin situhybridization for EBV RNA. One undifferentiated carcinoma from a European patient was included in the group. These results confirm previous reports of an

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Prince, Stuart, Sinead Keating, Ceri Fielding, Paul Brennan, Eike Floettmann, and Martin Rowe. "Latent Membrane Protein 1 Inhibits Epstein-Barr Virus Lytic Cycle Induction and Progress via Different Mechanisms." Journal of Virology 77, no. 8 (2003): 5000–5007. http://dx.doi.org/10.1128/jvi.77.8.5000-5007.2003.

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ABSTRACT Epstein-Barr virus (EBV) is a potent growth-transforming agent of human B cells. It has previously been shown that viral latent membrane protein 1 (LMP1) is essential for EBV-induced transformation of normal B cells and contributes to maintenance of latency in vitro. Using the EBV-positive Burkitt's lymphoma line P3HR1-c16, which lacks LMP1 during latency and which can readily be activated into virus-productive lytic cycle, we found that LMP1 inhibits lytic cycle induction via the transcription factor NF-κB. In addition, LMP1 inhibits lytic cycle progress via two distinct NF-κB-indepe

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Repic, Allison M., Mingxia Shi, Rona S. Scott, and John W. Sixbey. "Augmented Latent Membrane Protein 1 Expression from Epstein-Barr Virus Episomes with Minimal Terminal Repeats." Journal of Virology 84, no. 5 (2009): 2236–44. http://dx.doi.org/10.1128/jvi.01972-09.

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ABSTRACT The major oncogene of the Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1), can be expressed from either of two promoters, ED-L1 or L1-TR, producing mRNAs of 2.8 kb or 3.5 kb, respectively. L1-TR, active in nasopharyngeal carcinoma and Hodgkin's lymphoma, is located within the first of a highly variable reiteration of terminal repeat (TR) sequences that are joined by random recombination upon circularization of the linear genome at entry into cells. To determine whether the resultant TR number affects LMP1 promoter activity, we isolated single-cell clones bearing episomes of

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Burton, Eric M., Davide Maestri, Shaowen White, et al. "Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism." PLOS Pathogens 21, no. 5 (2025): e1013092. https://doi.org/10.1371/journal.ppat.1013092.

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Epstein-Barr virus (EBV) is associated with multiple types of cancers, many of which express the viral oncoprotein Latent Membrane Protein 1 (LMP1). LMP1 contributes to both epithelial and B-cell transformation. Although metabolism reprogramming is a cancer hallmark, much remains to be learned about how LMP1 alters lymphocyte oncometabolism. To gain insights into key B-cell metabolic pathways subverted by LMP1, we performed systematic metabolomic analyses on B cells with conditional LMP1 expression. This approach highlighted that LMP highly induces de novo purine biosynthesis, with xanthosine-

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Taniere, P., A. Manai, R. Charpentier, et al. "Pyothorax-associated lymphoma: relationship with Epstein-Barr virus, human herpes virus-8 and body cavity-based high grade lymphomas." European Respiratory Journal 11, no. 3 (1998): 779–83. http://dx.doi.org/10.1183/09031936.98.11030779.

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Pyothorax-associated lymphoma (PAL) is a newly-described entity developing several decades after artificial pneumothorax treatment for pulmonary or pleural tuberculosis. It is known to be associated with Epstein-Barr virus (EBV) with constant expression of the two latent membrane proteins: latent membrane protein (LMP)-1 and EBV-associated nuclear antigen (EBNA)-2. We are reporting three new cases of PAL. All of the tumours were of B-cell lineage and classified as large-cell diffuse lymphomas according to the International Working Formulation for the Classification of Lymphomas. The EBV genome

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Kusano, Shuichi, and Nancy Raab-Traub. "An Epstein-Barr Virus Protein Interacts with Notch." Journal of Virology 75, no. 1 (2001): 384–95. http://dx.doi.org/10.1128/jvi.75.1.384-395.2001.

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ABSTRACT The Epstein-Barr virus (EBV) BamHI A mRNAs were originally identified in cDNA libraries from nasopharyngeal carcinoma, where they are expressed at high levels. The RNAs are differentially spliced to form several open reading frames and also contain the BARF0 open reading frame at the 3′ end. One cDNA, RK-BARF0, included a potential endoplasmic reticulum-targeting signal peptide sequence. The RK-BARF0 protein is shown here to interact with the Notch4 ligand binding domain, using yeast two-hybrid screening, coimmunoprecipitation, and confocal microscopy. This interaction induces translo

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Swanson-Mungerson, Michelle, Rebecca Bultema, and Richard Longnecker. "Epstein-Barr Virus Latent Membrane Protein 2A protects B cells from MYC-induced apoptosis and accelerates tumor development (45.14)." Journal of Immunology 182, no. 1_Supplement (2009): 45.14. http://dx.doi.org/10.4049/jimmunol.182.supp.45.14.

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Abstract Despite its initial isolation from Burkitt's lymphoma (BL) tumors over 40 years ago, the exact contribution of Epstein-Barr Virus (EBV) to BL is undefined. EBV encodes for multiple proteins in latently-infected B cells that affect B cell survival and activation. Due to the ability of one of these latency proteins, latent membrane protein 2A (LMP2A) to protect B cells from apoptosis, we tested if LMP2A protects B cells from apoptosis induced by aberrant c-MYC expression that precedes and dominates BL. We crossed LMP2A-transgenic mice (LMP2A-Tg) in which all B cells express LMP2A to a t

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Swanson-Mungerson, Michelle A., Robert G. Caldwell, Rebecca Bultema, and Richard Longnecker. "Epstein-Barr Virus LMP2A Alters In Vivo and In Vitro Models of B-Cell Anergy, but Not Deletion, in Response to Autoantigen." Journal of Virology 79, no. 12 (2005): 7355–62. http://dx.doi.org/10.1128/jvi.79.12.7355-7362.2005.

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ABSTRACT A significant percentage of the population latently harbors Epstein-Barr virus (EBV) in B cells. One EBV-encoded protein, latent membrane protein 2A (LMP2A), is expressed in tissue culture models of EBV latent infection, in human infections, and in many of the EBV-associated proliferative disorders. LMP2A constitutively activates proteins involved in the B-cell receptor (BCR) signal transduction cascade and inhibits the antigen-induced activation of these proteins. In the present study, we investigated whether LMP2A alters B-cell receptor signaling in primary B cells in vivo and in vi

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Šimičić, Petra, Margarita Batović, Anita Stojanović Marković, and Snjezana Židovec-Lepej. "Deciphering the Role of Epstein–Barr Virus Latent Membrane Protein 1 in Immune Modulation: A Multifaced Signalling Perspective." Viruses 16, no. 4 (2024): 564. http://dx.doi.org/10.3390/v16040564.

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The disruption of antiviral sensors and the evasion of immune defences by various tactics are hallmarks of EBV infection. One of the EBV latent gene products, LMP1, was shown to induce the activation of signalling pathways, such as NF-κB, MAPK (JNK, ERK1/2, p38), JAK/STAT and PI3K/Akt, via three subdomains of its C-terminal domain, regulating the expression of several cytokines responsible for modulation of the immune response and therefore promoting viral persistence. The aim of this review is to summarise the current knowledge on the EBV-mediated induction of immunomodulatory molecules by th

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Zhang, Jun, Subash C. Das, Catherine Kotalik, Asit K. Pattnaik, and Luwen Zhang. "The Latent Membrane Protein 1 of Epstein-Barr Virus Establishes an Antiviral State via Induction of Interferon-stimulated Genes." Journal of Biological Chemistry 279, no. 44 (2004): 46335–42. http://dx.doi.org/10.1074/jbc.m403966200.

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Epstein-Barr virus (EBV) infection is associated with several human cancers. Latent membrane protein 1 (LMP-1) is one of the key viral proteins required for transformation of primary B cellsin vitroand establishment of EBV latency. In this report, we show that LMP-1 is able to induce the expression of several interferon (IFN)-stimulated genes (ISGs) with antiviral properties such as 2′-5′ oligoadenylate synthetase (OAS), stimulatedtrans-acting factor of 50 kDa (STAF-50), and ISG-15. LMP-1 inhibits vesicular stomatitis virus (VSV) replication at low multiplicity of infection (0.1 pfu/cell). The

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Alexander, D. R., J. M. Hexham, and M. J. Crumpton. "The association of type 1, type 2A and type 2B phosphatases with the human T lymphocyte plasma membrane." Biochemical Journal 256, no. 3 (1988): 885–92. http://dx.doi.org/10.1042/bj2560885.

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Several putative plasma-membrane-associated components of the T-lymphocyte signal-transduction pathway are phosphorylated during the initial events of cellular activation. Little is known about the control of dephosphorylation of these components. We have shown by immunoblotting that the type 1 phosphatase, the type 2A phosphatase and type 2B phosphatase (calcineurin) are associated with the plasma membrane of normal human T lymphoblasts and the human T leukaemic cell line Jurkat 6. The type 1 phosphorylase phosphatase activity is present in a latent form which can be stimulated synergisticall

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Incrocci, Ryan, Rosalinda Monroy Del Toro, Grace Devitt, Melody Salimian, Kamaljit Braich та Michelle Swanson-Mungerson. "Epstein–Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances ATP Production in B Cell Tumors through mTOR and HIF-1α". International Journal of Molecular Sciences 25, № 7 (2024): 3944. http://dx.doi.org/10.3390/ijms25073944.

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Epstein–Barr Virus (EBV) exists in a latent state in 90% of the world’s population and is linked to numerous cancers, such as Burkitt’s Lymphoma, Hodgkin’s, and non-Hodgkin’s Lymphoma. One EBV latency protein, latency membrane protein 2A (LMP2A), is expressed in multiple latency phenotypes. LMP2A signaling has been extensively studied and one target of LMP2A is the mammalian target of rapamycin (mTOR). Since mTOR has been linked to reprogramming tumor metabolism and increasing levels of hypoxia-inducible factor 1 α (HIF-1α), we hypothesized that LMP2A would increase HIF-1α levels to enhance AT

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Penkert, Rhiannon R., and Robert F. Kalejta. "Nuclear Localization of Tegument-Delivered pp71 in Human Cytomegalovirus-Infected Cells Is Facilitated by One or More Factors Present in Terminally Differentiated Fibroblasts." Journal of Virology 84, no. 19 (2010): 9853–63. http://dx.doi.org/10.1128/jvi.00500-10.

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ABSTRACT Herpesviral virions contain a tegument layer that consists primarily of viral proteins. The delivery of fully functional proteins to infected cells upon virion envelope fusion to the plasma membrane allows herpesviruses to modulate cellular activities prior to viral gene expression. Certain tegument proteins can also regulate viral processes. For example, the pp71 tegument protein encoded by the UL82 gene of human cytomegalovirus (HCMV) stimulates viral immediate early (IE) gene expression and thus acts to initiate the productive lytic infectious cycle. In terminally differentiated fi

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Angrayany Sapar, Puput, Hamsu Kadriyan, and Didit Yudhanto. "Preliminary Study On Latent Membrane Protein-1 (LMP-1) And Bcl-2 Associated X (BAX) In Exosomes Of Patients With Nasopharingeal Cancer In NTB Provincial Hospital." KESANS : International Journal of Health and Science 1, no. 2 (2021): 117–30. http://dx.doi.org/10.54543/kesans.v1i2.9.

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Nasopharyngeal cancer is one of the most common types of cancer in Indonesia, especially head and neck cancer. One of the etiology of this cancer is infection with Epstein-Barr virus. Early diagnosis is difficult to establish because the early signs and symptoms of nasopharyngeal carcinoma are not specific. Examination of latent membrane protein-1 (LMP1) oncogene expression and BCL2-associated X (BAX) gene expression proved to be useful in the identification of nasopharyngeal cancer. LMP1 oncogene is an oncogene that functions as a tumor necrosis factor receptor (TNFR), so that apoptosis does

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Priti, Dipa Anesha, Ali Firoz, and Tiwari Abhishek. "Advances in Human Milk Fortification with Added Supplements." International Journal of Innovative Science and Research Technology 8, no. 1 (2023): 2467–75. https://doi.org/10.5281/zenodo.7677201.

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Humans require a variety of critical nutrients, and milk is one of the most significant sources of these nutrients. Farm animal milk, whether in the form of cheese, curd, butter, or other fermented or biotransformed products, is a common source of nutrients. Proteins and lipids are important components of milk's functional component, and studying them is a difficult task. Caseins, a type of protein found in milk, help to produce micelles that vary in size and casein content depending on the species;They play a significant role in the MFGM (Milk Fat Globule Membrane), a topic of recent, int

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Caldwell, Robert G., R. Clark Brown та Richard Longnecker. "Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic Mice". Journal of Virology 74, № 3 (2000): 1101–13. http://dx.doi.org/10.1128/jvi.74.3.1101-1113.2000.

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ABSTRACT Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgenic mouse lines (EμLMP2A) with B-cell lineage expression of LMP2A were generated in this study to analyze the importance of LMP2A expression in vivo. These animals can be grouped into EμLMP2ABCR+ (TgB, Tg6, and TgC) and EμLMP2ABCR− (Tg7 and TgE) lines based on B-cell pheno

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Redchenko, I. V., and A. B. Rickinson. "Accessing Epstein-Barr Virus-Specific T-Cell Memory with Peptide-Loaded Dendritic Cells." Journal of Virology 73, no. 1 (1999): 334–42. http://dx.doi.org/10.1128/jvi.73.1.334-342.1999.

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ABSTRACT The conventional means of studying Epstein-Barr virus (EBV)-induced cytotoxic T-lymphocyte (CTL) memory, by in vitro stimulation with the latently infected autologous lymphoblastoid cell line (LCL), has important limitations. First, it gives no information on memory to lytic cycle antigens; second, it preferentially amplifies the dominant components of latent antigen-specific memory at the expense of key subdominant reactivities. Here we describe an alternative approach, based on in vitro stimulation with epitope peptide-loaded dendritic cells (DCs), which allows one to probe the CTL

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Swanson-Mungerson, Michelle, Ryan Incrocci, Molly McCormack, and Caroline Leof. "Effects of Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) on cytokine production in primary and transformed B cells (105.40)." Journal of Immunology 188, no. 1_Supplement (2012): 105.40. http://dx.doi.org/10.4049/jimmunol.188.supp.105.40.

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Abstract Epstein-Barr Virus (EBV) latently-infected B cells are precursors of EBV-associated malignancies. However, the transition from a latently-infected cell to a malignant tumor cell is poorly understood. Studies show that EBV modulates pro-survival and anti-inflammatory cytokine levels in EBV-transformed cell lines. However, gene expression in these cell lines may not reflect gene expression found in latent B cells and lymphomas. One EBV protein, LMP2A, is consistently detected in both latently-infected resting B cells, as well as in EBV-associated malignancies. Therefore, we hypothesized

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Joske, DJ, A. Emery-Goodman, E. Bachmann, F. Bachmann, B. Odermatt, and H. Knecht. "Epstein-Barr virus burden in Hodgkin's disease is related to latent membrane protein gene expression but not to active viral replication." Blood 80, no. 10 (1992): 2610–13. http://dx.doi.org/10.1182/blood.v80.10.2610.2610.

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Abstract The Epstein-Barr virus (EBV) has been increasingly detected in Hodgkin's disease (HD), but its role in pathogenesis remains uncertain. We analyzed 20 specimens of HD known to contain EBV DNA by a sensitive reverse transcriptase polymerase chain reaction (RT-PCR). The cases were assessed for the presence of RNA transcripts of the BNLF1 gene (coding for the viral latent membrane protein [LMP]) and the late replicative gene BLLF1 (coding for the principle envelope glycoprotein [gp220/350]). LMP RNA transcripts were found in 9 of 20 (45%) cases, mostly those containing many copies of vira

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Joske, DJ, A. Emery-Goodman, E. Bachmann, F. Bachmann, B. Odermatt, and H. Knecht. "Epstein-Barr virus burden in Hodgkin's disease is related to latent membrane protein gene expression but not to active viral replication." Blood 80, no. 10 (1992): 2610–13. http://dx.doi.org/10.1182/blood.v80.10.2610.bloodjournal80102610.

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The Epstein-Barr virus (EBV) has been increasingly detected in Hodgkin's disease (HD), but its role in pathogenesis remains uncertain. We analyzed 20 specimens of HD known to contain EBV DNA by a sensitive reverse transcriptase polymerase chain reaction (RT-PCR). The cases were assessed for the presence of RNA transcripts of the BNLF1 gene (coding for the viral latent membrane protein [LMP]) and the late replicative gene BLLF1 (coding for the principle envelope glycoprotein [gp220/350]). LMP RNA transcripts were found in 9 of 20 (45%) cases, mostly those containing many copies of viral DNA and

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37

Steinbrück, Lisa, Montse Gustems, Stephanie Medele, Thomas F. Schulz, Dominik Lutter, and Wolfgang Hammerschmidt. "K1 and K15 of Kaposi's Sarcoma-Associated Herpesvirus Are Partial Functional Homologues of Latent Membrane Protein 2A of Epstein-Barr Virus." Journal of Virology 89, no. 14 (2015): 7248–61. http://dx.doi.org/10.1128/jvi.00839-15.

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ABSTRACTThe human herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are associated with Hodgkin's lymphoma (HL) and Primary effusion lymphomas (PEL), respectively, which are B cell malignancies that originate from germinal center B cells. PEL cells but also a quarter of EBV-positive HL tumor cells do not express the genuine B cell receptor (BCR), a situation incompatible with survival of normal B cells. EBV encodesLMP2A, one of EBV's viral latent membrane proteins, which likely replaces the BCR's survival signaling in HL. Whether KSHV encodes a viral BCR

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Mansourizadeh, A., and K. Mansourizadeh. "Book Review Hollow Fiber Membrane Contactors: Module Fabrication, Design and Operation, and Potential Applications." Journal of Applied Membrane Science & Technology 27, no. 2 (2023): 115–23. http://dx.doi.org/10.11113/amst.v27n2.272.

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The latest developments and applications of hollow fiber membrane contactors (HFMCs) were discussed in this recent published book. Membrane contactor provides gas–liquid or liquid–liquid contact without dispersion of one phase in another, which gives a higher mass transfer coefficient compared to the conventional contactors. Using a microporous hydrophobic or hydrophilic membrane, one of the fluids is immobilized in the pores where the mass transfer is occurred based on the concentration gradient. HFMC technology has been implemented in various applications including gas separation, fermentati

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Yang, C.-F., G.-D. Yang, T.-J. Huang, et al. "EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop." Oncogene 35, no. 26 (2015): 3419–31. http://dx.doi.org/10.1038/onc.2015.402.

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Hay, David C., Graham D. Kemp, Catherine Dargemont та Ronald T. Hay. "Interaction between hnRNPA1 and IκBα Is Required for Maximal Activation of NF-κB-Dependent Transcription". Molecular and Cellular Biology 21, № 10 (2001): 3482–90. http://dx.doi.org/10.1128/mcb.21.10.3482-3490.2001.

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ABSTRACT Transcriptional activation of NF-κB is mediated by signal-induced phosphorylation and degradation of its inhibitor, IκBα. NF-κB activation induces a rapid resynthesis of IκBα which is responsible for postinduction repression of transcription. Following resynthesis, IκBα translocates to the nucleus, removes template bound NF-κB, and exports NF-κB to the cytoplasm in a transcriptionally inactive form. Here we demonstrate that IκBα interacts directly with another nucleocytoplasmic shuttling protein, hnRNPA1, both in vivo and in vitro. This interaction requires one of the N-terminal RNA b

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Shibata, D., LM Weiss, AM Hernandez, BN Nathwani, L. Bernstein, and AM Levine. "Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus [see comments]." Blood 81, no. 8 (1993): 2102–9. http://dx.doi.org/10.1182/blood.v81.8.2102.2102.

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Abstract Lymphoproliferations associated with Epstein-Barr virus (EBV) commonly arise in settings of immune dysfunction, including human immunodeficiency virus (HIV) infection. In this study, EBV was associated with 39 of 59 (66%) HIV-related systemic lymphomas. Unlike the lymphoproliferations that arise in the setting of transplantation, the HIV-related lymphomas were monoclonal, as evaluated by Ig heavy chain rearrangements and EBV termini analysis, and associated (40%) with c-MYC rearrangements. Furthermore, analysis of multiple lymphoma tissues from one autopsy showed evidence that a singl

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Shibata, D., LM Weiss, AM Hernandez, BN Nathwani, L. Bernstein, and AM Levine. "Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus [see comments]." Blood 81, no. 8 (1993): 2102–9. http://dx.doi.org/10.1182/blood.v81.8.2102.bloodjournal8182102.

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Lymphoproliferations associated with Epstein-Barr virus (EBV) commonly arise in settings of immune dysfunction, including human immunodeficiency virus (HIV) infection. In this study, EBV was associated with 39 of 59 (66%) HIV-related systemic lymphomas. Unlike the lymphoproliferations that arise in the setting of transplantation, the HIV-related lymphomas were monoclonal, as evaluated by Ig heavy chain rearrangements and EBV termini analysis, and associated (40%) with c-MYC rearrangements. Furthermore, analysis of multiple lymphoma tissues from one autopsy showed evidence that a single lymphom

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Bollard, Catherine M., Maja Stanojevic, Ann M. Leen, et al. "Complete Tumor Responses in Lymphoma Patients Who Receive Autologous Cytotoxic T Lymphocytes Targeting EBV Latent Membrane Proteins." Blood 112, no. 11 (2008): 230. http://dx.doi.org/10.1182/blood.v112.11.230.230.

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Abstract EBV-associated Hodgkin’s Lymphoma (HL) and some non-Hodgkins lymphoma (NHL) have type II viral latency expressing the subdominant EBV antigens EBNA1, LMP1 and LMP2. These antigens may serve as targets for immunotherapy approaches and in previous studies, we used polyclonal EBV-specific CTL in patients with relapsed EBV +ve HL obtaining 2 complete and 1 partial response in 11 patients. Analyses of EBV-CTL lines showed that small populations of T cells reactive against the tumor-associated antigen LMP2 were present in the majority of the infused lines, with some expansion in the periphe

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Faumont, Nathalie, Talal Al Saati, Pierre Brousset, Claudie Offer, Georges Delsol, and Fabienne Meggetto. "Demonstration by single-cell PCR that Reed–Sternberg cells and bystander B lymphocytes are infected by different Epstein–Barr virus strains in Hodgkin’s disease." Journal of General Virology 82, no. 5 (2001): 1169–74. http://dx.doi.org/10.1099/0022-1317-82-5-1169.

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Epstein–Barr virus (EBV) is associated with Hodgkin’s disease (HD). However, EBV-positive Reed–Sternberg (RS) cells and EBV-positive B lymphocytes co-exist in the same EBV-positive lymph node affected by HD. In a previous report, using total lymph node DNA, the presence of two distinct EBV strains was demonstrated, but their cellular localization (i.e. RS cells vs B lymphocytes) could not be determined. To address this question, three patients with EBV-associated HD were selected in the present study and single-cell PCR of the latent membrane protein-1 (LMP-1) gene from isolated RS cells was p

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Camilleri-Broet, S., F. Davi, J. Feuillard, et al. "High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas." Blood 86, no. 2 (1995): 432–35. http://dx.doi.org/10.1182/blood.v86.2.432.bloodjournal862432.

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Nearly all primary brain lymphomas in acquired immunodeficiency syndrome (AIDS) patients are associated withEpstein-Barr virus (EBV). The role of EBV in lymphomagenesis is not totally elucidated. One possible mechanism is the overexpression of the BCL-2 oncoprotein, because the latent membrane protein 1 (LMP1) has been reported to transactivate the bcl-2 gene in vitro. To study the interrelationship beetween LMP1 and BCL-2 in vivo, we have analyzed and compared their expression in 11 AIDS-related primary brain lymphomas and 57 AIDS- related systemic lymphomas by immunoperoxidase technique on f

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Palefsky, Joel M., Jennifer Berline, Deborah Greenspan, and John S. Greenspan. "Evidence for trafficking of Epstein–Barr virus strains between hairy leukoplakia and peripheral blood lymphocytes." Journal of General Virology 83, no. 2 (2002): 317–21. http://dx.doi.org/10.1099/0022-1317-83-2-317.

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Hairy leukoplakia (HL), an epithelial lesion found on the side of the tongue in immunocompromised individuals, is characterized by high-level replication of Epstein–Barr virus (EBV) and multiple EBV strains. The source of these strains and their relationship to peripheral blood lymphocyte (PBL) strains has not previously been characterized. Using matched pairs of HL scrapings and PBL from 16 HIV-positive men, variation in EBV strain identity was characterized by detection of a 30 nucleotide deletion of the EBV latent membrane protein (LMP)-1 gene, variation in the LMP-1 repeat region and typin

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Samir, Safia, Hend Okasha Ahmed, Tarek M. Diab, et al. "Rate of Epstein-Barr Virus in Gastric Adenocarcinoma in Egyptian Patients in View of the WHO Classification and Correlation with p16 Immunoreactivity." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 1218–25. http://dx.doi.org/10.3889/oamjms.2022.9700.

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BACKGROUND AND AIM: Gastric cancer (GC) is one of the top causes of cancer-related deaths worldwide. According to the Cancer Genome Atlas, there are four subtypes of GC, with the Epstein-Barr virus (EBV) subtype accounting for about 10% of cases. EBV infection causes EBV-associated GC (EBVaGC). The previous research suggested that the presence of the EBV viral genome in gastric carcinomas could be used as a surrogate marker for targeted therapy and optimal GC treatment. AIM: We aimed to explore the rate of EBV involvement in gastric carcinogenesis from molecular perspective view and to evaluat

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Conacher, Margaret, Robin Callard, Karen McAulay, et al. "Epstein-Barr Virus Can Establish Infection in the Absence of a Classical Memory B-Cell Population." Journal of Virology 79, no. 17 (2005): 11128–34. http://dx.doi.org/10.1128/jvi.79.17.11128-11134.2005.

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ABSTRACT Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that persists in the body for life after primary infection. The primary site of EBV persistence is the memory B lymphocyte, but whether the virus initially infects naïve or memory B cells is still disputed. We have analyzed EBV infection in nine cases of X-linked hyper-immunoglobulin M (hyper-IgM) syndrome who, due to a mutation in CD40 ligand gene, do not have a classical, class-switched memory B-cell population (IgD− CD27+). We found evidence of EBV infection in 67% of cases, which is similar to the infection rate found in

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Abdullah, Zahraa, Ahmed Abdulamir, and Faiq Gorial. "The Possible Role of Epstein Barr Virus and Its Latent Proteins in Systemic Lupus Erythematosus Patients." Iraqi Journal of Medical Sciences 18, no. 1 (2020): 4–11. http://dx.doi.org/10.22578/ijms.18.1.2.

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Background:Systemic lupus erythematosus is a chronic, systemic, idiopathic autoimmune disease. One of the suggested environmental factors that lead to development of systemic lupus erythematosus is infection with Epstein-Barr virus. Objective: First, detection and quantification of Epstein-Barr virus in peripheral blood of systemic lupus erythematosus patients compared to control. Second, estimation of mRNA level of latent and lytic genes and compare them with control groups. Methods: This a case-control study conducted on systemic lupus erythematosus patients during the period from (December

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Kelly, Gemma L., Julianna Stylianou, Andrew I. Bell, Wenbin Wei, Martin Rowe, and Alan B. Rickinson. "Three Restricted Forms of Epstein-Barr Virus Latency Counteracting Apoptosis in c-Myc Expressing Burkitt Lymphoma Cells." Blood 110, no. 11 (2007): 1572. http://dx.doi.org/10.1182/blood.v110.11.1572.1572.

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Abstract Epstein-Barr virus (EBV) is aetiologically linked with Burkitt Lymphoma (BL) but its contribution to lymphomagenesis, versus that of the chromosomal translocation activating c-myc expression, remains unclear. This is in part because the full virus growth transforming programme that is expressed when EBV infects normal resting B cells, is not expressed in BL. Instead EBV in BL normally exhibits a restricted Latency I form of infection characterised by expression of only one latent antigen EBNA1 from the BamHI Q promoter. Here we describe an endemic BL, Awia, which uniquely is heterogen

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