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Dissertations / Theses on the topic 'LC-MS/MS detection'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wong, Chun-kit Jack. "Application of immunochemical and LC/MS/MS techniques in the detection of sulfonamide residues in livestock /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36886294.

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2

Gómez, Castellà Cristina 1985. "Improving detection capabilities of doping agents by identification of new phase I and phase II metabolites by LC-MS/MS." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/132539.

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Metabolic studies of doping agents have been traditionally performed by using gas chromatography coupled to mass spectrometry (GC-MS). In the last years, liquid chromatography coupled to mass spectrometry (LC-MS) has demonstrated to offer new possibilities to perform metabolic studies. The objective of this thesis was to study the metabolism (phase I and phase II) of different doping agents by LC-MS/MS in order to improve the detection capabilities of the studied substances. For mesocarb, a thermolabile compound, the parent drug 19 metabolites were detected in urine including mono-, di- and t

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3

Planinc, Ana. "Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/241427/4/Table.pdf.

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Biopharmaceuticals are becoming one of the most promising drugs on the market mainly due to their successful treatment of a vast array of serious diseases, such as cancers, immune disorders, and infections. Structurally, biopharmaceuticals are proteins and it is important to mention that more than 60 % of biopharmaceuticals are glycosylated. Glycosylation is one of the most common posttranslational modifications. It is also the most demanding and the most complex posttranslational modification. The research showed that glycosylation can significantly impact on the safety, efficiency, and quali

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4

Jora, Manasses. "Higher-energy Collisional Dissociation (HCD) as a Complementary Tool for Expanding the Detection and Discovery of Modified Ribonucleosides by LC-MS/MS." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613747846885246.

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5

Alberts, P. "Development of a novel LC-MS/MS method for the detection of adulteration of South African sauvignon blanc wines with 3-alkyl-2-methoxypyrazines." Thesis, Link to the Internet, 2008. http://hdl.handle.net/10019/805.

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6

Methling, Maximilian [Verfasser]. "Detection of psychoactive substances (antidepressants, antipsychotics, benzodiazepines, alcohol) in human hair and other matrices using liquid chromatography-mass spectrometry (LC-MS/MS) / Maximilian Methling." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1217251324/34.

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7

Strayer, Kraig Edward. "A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317.

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8

NOBILE, MARIA. "DEVELOPMENT AND VALIDATION OF METHODS FOR THE DETECTION OF RESIDUES IN UNCONVENTIONAL AND INNOVATIVE MATRICES THROUGH LC-MS/MS ANALYSES FOR SAFETY OF FOOD OF ANIMAL ORIGIN." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/547683.

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Successful animal growth depends on a combination of many factors related to health, management and nutrition. The use of veterinary drugs in food-producing animals for therapeutic purposes is regulated (corticosteroids, antibiotics) or banned (anabolic steroids) in the European Union; however, their use as growth promoters cannot be excluded. Moreover, the eventual presence of residues in food constitutes a fraud and a health issue for the consumers. For these reasons the need to find new accumulation matrices and new sensitive, specific and robust methods that are able to reveal the presence

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9

Wei, Li. "Part I: Oxidative Modification of Ethanolamine Phospholipids by Isolevuglandins: Detection by LC-MS/MS in Vitro and in Vivo Part II: Total Synthesis of C22-11-isolevuglandin E4." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251210773.

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10

Carlin, Michelle. "Development and evaluation of an LC-ESI-MS method for the simultaneous detection of five major opium alkaloids." Thesis, Northumbria University, 2015. http://nrl.northumbria.ac.uk/27317/.

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The aim of this work was to establish an analytical method for the simultaneous detection of five major opium alkaloids in poppy seeds by liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS). Once opium alkaloids were detected in poppy seeds, toxicological studies were carried out to establish if these compounds were detected in oral fluid (OF) of participants who ingested muffins containing poppy seeds. It is known that the ingestion of poppy seeds has caused positive opiate drug test results and much work has been reported in the scientific literature in the last 20 ye

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11

Shi, Jianzheng. "Nitrosation studies of tolazoline, an antihypertensive drug and LC/MS detection of DNA adducts derived from N-nitrosotolazoline /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074442.

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12

Wynn, Michelle Arelia Ann. "Biology and Detection of Pregnanes During Late Gestation in the Mare." UKnowledge, 2017. http://uknowledge.uky.edu/gluck_etds/28.

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Progesterone in the mare declines to almost undetectable concentrations in late gestation. It’s metabolized into several pregnanes, some circulating at very high concentrations. Although the function of many pregnanes remains unclear, 5α-dihydroprogesterone and allopregnanolone are bioactive. Measurements of pregnanes in late gestation are typically by immunoassay, although results are confounded by cross-reactivity with related pregnanes. Conversely, liquid chromatography tandem mass spectrometry (LC-MS/MS) allows differentiation of individual pregnanes. The purposes of these studies were: 1)

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13

Li, Meihui. "A comprehensive study of natural organic dyes in historical mediterranean textil by liquid chromatography with photodiode array and mass spectrometric detection." Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/27739.

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Thesis involves an optimized chromatographic and spectroscopic study of textiles, dyed with natural organic dyestuffs, aiming at the identification of chromophore constituents and their possible degradation products. Liquid chromatography - mass spectrometry coupled with photodiode array detection has been applied for the samples’ analyses after the selective extraction of chromophores from the substrate. The under investigation natural organic dyes are those with a particular cultural value since they have been widely used for textiles staining in the Mediterranean region since Antiquit

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14

Höfig, Carolin. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16645.

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Thyronamine (TAM) sind eine neue Molekülklasse, die endokrinologische und metabolische Prozesse miteinander vereinen. Der biologisch aktive Metabolit 3-Iod-L-Thyronamin (3-T1AM) wird durch eine kombinierte Deiodierung und Decarboxylierung von Schilddrüsenhormonen (TH) gebildet. Existierende Methoden zum Nachweis und zur Quantifizierung von 3-T1AM im menschlichen Serum sind immer noch umstritten. Auch die an der Biosynthese vermutlich beteiligte TH-Decarboxylase konnte noch nicht identifiziert werden. Für die Identifizierung und Quantifizierung von TH und TAM Profilen wurde die Flüssigchromatog

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15

Barreras, Garcia Alvaro. "Food safety: developement of new methods for marine algal toxins detection." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8644.

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2011/2012<br>SUMMARY Biotoxins produced by harmful algae during their proliferation can be accumulated by filter feeding organisms, such as bivalve shellfish, within their flesh. Furthermore, these toxins gradually are transferred to the higher trophic levels in the food chain, posing a threat to human health, after consumption of contaminated seafood. Filter-feeding invertebrates are organisms in which the toxin accumulation is a well-known phenomenon, especially during harmful algal blooms. Mussels, cockles, oysters, and scallops feed on toxic dinoflagellates, transferring them from the

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16

Alothaim, Ibrahim. "Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=29531.

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Inflammatory bowel disease (IBD) is a chronic inflammation of all parts of the gastrointestinal tract and is represented by two major variations, ulcerative colitis (UC) and Crohn's disease (CD). It is diagnosed based on the pattern of inflammation. In order to understand the pathology of the disease better urine and saliva samples were collected from patients with IBD, patients in remission and a control group. The metabolomes of the urine and saliva samples were profiled by carrying out chromatography on a ZICpHILIC column in combination with high resolution mass spectrometry. It was possibl

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17

Esquivel, López Argitxu 1989. "Control of anabolic steroids misuse in sport : potential of direct detection of phase II metabolites." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665719.

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Anabolic androgenic steroids (AAS) are widely used by athletes to enhance sports performance. In this thesis, different studies were performed to evaluate the potential of the direct detection of phase II metabolites by LC-MS/MS to improve the detection of AAS misuse in sport. First, the direct detection of glucuronide metabolites was investigated using metandienone, allowing the detection of thirteen glucuronides, one of them resistant to enzymatic hydrolysis. The proposed analytical strategy provides a comprehensive approach and it is recommended to be used for metabolic studies of other

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18

Höfig, Carolin [Verfasser], Werner [Akademischer Betreuer] Kloas, Josef [Akademischer Betreuer] Köhrle, and Dagmar [Akademischer Betreuer] Führer-Sakel. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis / Carolin Höfig. Gutachter: Werner Kloas ; Josef Köhrle ; Dagmar Führer-Sakel." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1029763844/34.

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19

Dennehy, Michelle K. "Studies on the role of nitrosamines in carcinogenssis : Part I, LC-ESI-MS trace detection of glyoxal-deoxyguanosine and O⁶-hydroxyethyldeoxyguanosine ; Part II, Nitrosation reactions of a methaqualone drug analog /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091917.

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20

Wong, Chun-kit Jack, and 蔣蔚宜. "Application of immunochemical and LC/MS/MS techniques in the detectionof sulfonamide residues in livestock." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45011084.

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21

Larabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.

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L’objectif de ce travail a été de développer deux approches analytiques dédiées à l’analyse toxicologique des nouveaux produits de synthèse (NPS) dans différentes matrices biologiques (sang, urine et cheveux). La première est basée sur le criblage non ciblé par chimiluminescence sur biopuces et chromatographie liquide couplée à la spectrométrie de masse haute résolution (LC-HRMS) et la deuxième correspond à un criblage ciblé par spectrométrie de masse en tandem (LC-MS/MS). Ces deux approches ont ensuite été appliquées dans des études observationnelles pour évaluer la consommation de NPS dans d

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22

GOSETTI, FABIO. "Methods of analysis and control in food chemistry by chromatographic techniques with UV-Vis and mass spectrometry detections." Doctoral thesis, Università degli Studi del Piemonte Orientale, 2005. http://hdl.handle.net/10281/255650.

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Investigation in food science and technology, both by the food industry and governmental agencies, is based on the evaluation of food composition and characteristics. All food products require analysis as part of a quality management program that involves the development, the production processes and the control of the commercial product. The chemical composition and physical properties of food are necessary to evaluate the nutritive value, the functional characteristics and the acceptability of the food product. The nature of the sample and the specific use of the analysis dictate the choice

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23

Broecker, Sebastian. "Aufbau und Anwendung einer Methode zur Identifizierung und Quantifizierung von Giften und deren Metaboliten in Blut und Haaren in der Systematischen Toxikologischen Analyse mittels Flüssigchromatographie-Quadrupol-Flugzeitmassenspektrometrie-Kopplung (LC-QTOF-MS)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16461.

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Die Systematische Toxikologische Analyse (STA) stellt auf Grund der großen Vielfalt und der ständigen Zunahme an toxikologisch relevanten Substanzen eine der größten Herausforderungen in der chemischen Analyse dar. In der vorliegenden Arbeit wurde daher die Eignung der Flüssigchromatographie in Kombination mit der Hybrid-Quadrupol-Flugzeitmassenspektrometrie (LC-QTOF-MS) für diesen Zweck untersucht. Dazu wurden eine Datenbank mit über 7360 und eine CID-Spektrenbibliothek mit mehr als 2720 toxikologisch relevanten Substanzen erstellt und geeignete Probenvorbereitungsmethoden entwickelt. Die Erp

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24

Johnson, Renee Michelle. "Determining the analytical figures of merit from LC-MS/MS data." Thesis, 2017. https://hdl.handle.net/2144/26678.

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Synthetic drugs such as piperazines are among the most commonly abused drugs and are typically consumed by younger populations. Because of their popularity, developing optimized analytical strategies designed to improve detection and interpretation of synthetic piperazines is of interest to the forensic community. To improve the likelihood that a substance of interest is detected, careful evaluation into the mass spectrometry signal is required. However, with all analytical pursuits, there is a limit at which the substance cannot be detected with certainty; thus a threshold is commonly referre

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Huang, Shih-Yen, and 黃詩雁. "Quantitative detection of aloin in aloe drinks using LC-MS/MS method." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/87102055253558448724.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>103<br>Aloe has been extensively used for health drinks, external ointments, toiletries and cosmetics. Its physiologically active substances included aloe emodin, saponin and aloin, of which aloin possessed antioxidant capacity and diarrhea effect. The domestic beverage shops and supermarkets offer a variety of aloe drinks and related products, of which the product aloe juice with honey is the most popular. Little information of aloe drinks has been available. The purpose of this study was to investigate the contents of aloin in aloe drinks and related products purch

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Lin, Yi-Zhun, and 林怡諄. "Detection of Pyrrolizidine Alkaloids in Emilia sonchifolia (L.) DC. by LC/MS/MS." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/44508469133042738700.

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碩士<br>亞洲大學<br>保健營養生技學系<br>102<br>Emilia sonchifolia (L.) DC. (Lilac tasselflower, yi dain hong, Asteraceae). It’s effectiveness has anti-inflammatory, detoxifying, antipyretic , anti-fever and other effects. In this study, we have investigated the hepatotoxic and tumorigenic pyrrolizidine alkaloids (PAs) contained in Emilia sonchifolia (L.) DC. collected from several towns in Taiwan. Two structural types of PAs were identified from the ground whole plant by liquid chromatography (HPLC) method：otonecine bases，e.g. otosenine, petasitenine, desacetyldoronine, neosenkirkine, senkirkine, crotafolin

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Jen, Hsiao-Chin, and 任曉晶. "Studies on application of LC-MS and LC-MS/MS methods for determining tetrodotoxin and paralytic shellfish poison and application of surface enhanced Raman scattering detection for determining tetrodotoxin." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/96867317801588081542.

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博士<br>國立臺灣海洋大學<br>食品科學系<br>97<br>Among marine biotoxins, tetrodotoxin (TTX) and paralytic shellfish poisons (PSP) are well known as sodium channel blocking neurotoxins. Recently, TTX and PSP associated with food poisoning incidents have caused human fatalities and many illnesses in Taiwan. Four food poisoning incidents due to ingesting unknown gastropod and scallop occurred in Taiwan during 2005-2008. There were total of 9 victims inclusive of 1 brain died in Liuchiu Island, Tainan, Kaohsiung and Penghu counties. Based on the data of toxin analysis, gastropods Nassariidae Nassarius papillosus

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28

Lee, Daniel. "Detection and quantitation of 17 synthetic cannabinoids in human whole blood using LC-MS/MS following supported liquid extraction." Thesis, 2018. https://hdl.handle.net/2144/33037.

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Synthetic cannabinoids have become a growing concern in society. The extensive list of synthetic cannabinoids and the abuse rate has drawn the attention by government agencies throughout the world. These synthetic cannabinoids can adopt a number of different structures, while still acting on endogenous cannabinoid (CB1 and CB2) receptors. In addition, due to structural modifications of these synthetic cannabinoids, many of these compounds can bind to CB1 and CB2 receptors with greater affinity causing severe adverse and life-threatening effects. Because of their structural dissimilarity to the

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Ke, Yiling. "Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS." Thesis, 2020. https://hdl.handle.net/2144/41277.

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The opioid epidemic has become a serious public health problem in the United States. The increasing abuse of synthetic opioids has raised concerns in the society. Fentanyl is a synthetic opioid analgesic which has resulted in an increasing number of drug overdoses since 2013. In addition, fentanyl analogs, originally manufactured for use as analgesics or animal tranquilizers, have emerged in the United States drug market. Fentanyl and its analogs, similar to other opioids, work as full µ-agonists, binding with µ-receptors in the brain. Fentanyl and its analogs elicit more potent effects compar

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ZHUANG, YAO-WEI, and 莊曜瑋. "Magnetic Dispersive Solid-Phase Extraction Based on a Novel Adsorbent for the Detection of Azobenzene Dye in Foodstuffs by LC-DAD and LC-MS/MS." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/g66zsy.

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碩士<br>輔仁大學<br>化學系<br>105<br>Magnetic solid phase extraction (MSPE) is one of the most interesting sample preparation techniques developed in recent years. In this study, a new, rapid, and efficient MSPE by LC-DAD and LC-MS/MS were established for the extraction and sensitive detection of sunset yellow, Curcumin, methyl red, methyl orange, dimethyl yellow, diethyl yellow, Sudan I, and Sudan III in foodstuff samples. Therefore, several major factors, namely, the type of solvent using as the matrix for extraction, the type of desorption solvent and desorption time, the amount of sorbent, the amou

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Po-YiPeng and 彭柏頤. "Detection of estrogenic compounds in Taiwanese rivers by a yeast-based reporter gene assay in combination with LC-MS/MS." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/31833999403112009194.

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Mella, Malorie Ann. "Detection of cocaine and its major metabolites in bone following outdoor decomposition after chronic cocaine administration using 2D-LC/MS/MS." Thesis, 2017. https://hdl.handle.net/2144/20788.

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In the field of forensic toxicology, several challenges exist with quantification analysis of cocaine and metabolites in post mortem samples. Cocaine can prove difficult to detect and quantify in blood, urine, and soft tissues following extensive decomposition. Alternative matrices, such as hair, nails, and bone could prove useful in detecting chronic drug use in post-mortem toxicology cases. Detection and quantification of drugs in complex matrices is difficult to accomplish due to time-consuming extraction processes, and inability to detect an analyte at trace levels. Further, analysis of dr

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Violette, A., D. F. Cortes, J. A. Bergeon, Robert A. Falconer, and I. Toth. "Optimized LC-MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as penetration enhancers." 2008. http://hdl.handle.net/10454/4619.

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No<br>Piperacillin, a potent ß-lactam antibiotic, is effective in a large variety of Gram+ and Gram¿ bacterial infections but its administration is limited to the parenteral route as it is not absorbed when given orally. In an attempt to overcome this problem, we have synthesized a novel series of charged liposaccharide complexes of piperacillin comprising a sugar moiety derived from d-glucose conjugated to a lipoamino acid residue with varying side-chain length (cationic entity) and the piperacillin anion. A complete multiple reaction monitoring LC¿MS/MS method was developed to detect and cha

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Gardner, Jenna Elizabeth. "Detection and quantitation of cannabidiol and delta(9) tetrahydrocannabinol in oral fluid of a therapeutic-use cannabidiol donor using the QSight 220 CR LC-MS/MS." Thesis, 2020. https://hdl.handle.net/2144/41241.

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Cannabidiol (CBD) is one of over 80 active cannabinoids found in Cannabis Sativa and is the second most abundant cannabinoid derived from the plant following d(9)-Tetrahydrocannabinol (THC). As opposed to THC, CBD does not appear to have any psychotropic effects, rather CBD is often utilized for its therapeutic properties, which include effects such as antinociception, anti-convulsion, and anti-inflammation. During the extraction of CBD from plant material, THC may be co-extracted. Therefore, screening and quantitating potential THC levels in individuals using CBD products is important in inst

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Fang, Szi-Han, and 方思涵. "Development Detection System Using Fiber-Optic Particle Plasmon Resonance (FOPPR) Coupled with Liquid Chromatography-Mass Spectrometry (LC-MS)." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/35674804736023010260.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>101<br>(1) Determination of illicit drugs methamphetamine (MA) Use of illicit drugs often causes addictions, resulting in severe harms to health. Illicit drugs have also been responsible for a recent surge of diverse crimes and a series of social problems in Taiwan. In this study, we aim to integrate FOPPR biosensor with LC-MS to develop a detection system for illicit drug determination as an alternative method to standard protocols which are not able to carry out fast screening test of large amount of suspected samples and confirmation test of much smaller amou

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Law, Ka Kiu Natalie. "Comparison of standard operating procedures used for the detection of opioids in blood." Thesis, 2020. https://hdl.handle.net/2144/41289.

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In forensic toxicology, opioids are frequently associated with drug abuse or drug-related death cases. An optimal method for use in the identification and quantification of opioids in a complex blood matrix is of paramount importance. Along with the ability to identify and quantitate opioids, this method should be accurate, sensitive, and selective. The application of sample pre-treatment and solid-phase extraction are common to purify and concentrate the target analytes before analyzing with liquid chromatography-tandem mass spectrometry. The purpose of this study was to compare the perfor

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Chen, Pei-Zhen, and 陳姵蓁. "Development of A Microfluidic Device Integrated with A LC-MS/MS System for Detecting Psychoactive Substance." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5tx286.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>107<br>How to rapidly analyze the drug compound is an emerging demand and this study intends to integrate a microfluidic chip with a LC-MS/MS system to address this issue. Since the operation pressure of compound separation in a microchannel is relatively high and how to completely seal the separation particle inside the microchannel is quite difficult, chip manufacturing is quite challenging. Two approaches were used, (1) ethanol solution and wall structure with UV glue were used to bond the chip with securing the particles inside the microchannel; (2) C-type fixtur

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Po-YuChen and 陳柏佑. "Detecting the variations of (anti-)estrogenic, (anti-)androgenic, and (anti-)mineralocorticoid activities in Taiwanese wastewater treatment plants using bioassays and LC-MS/MS." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/99942170710568299001.

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碩士<br>國立成功大學<br>環境工程學系<br>104<br>SUMMARY Endocrine disrupting chemicals (EDCs) are synthetic or naturally chemicals which can effect endocrine system of organisms. Different kinds of EDCs would show various kinds of activities, such as estrogen receptor (ER) disrupting activities, androgen receptor (AR) disrupting activities, or mineralocorticoid receptor (MR) disrupting activities, etc. In this work, recombinant yeast bioassays were used to identify ER, AR, and MR disrupting activities in samples collected from wastewater treatment plants (WWTPs) in Taiwan. Also, chemical analysis was carried

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