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Journal articles on the topic 'LC-MS/MS detection'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wicka, Mariola, Piotr Chołbiński, Dorota Kwiatkowska, and Andrzej Pokrywka. "Detection of psychotropic substances in the blood by LC/MS/MS." Issues of Forensic Science 284 (2014): 60–69. http://dx.doi.org/10.34836/pk.2014.284.3.

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Year on year, one can observe an increase in the use of addictive substances. This leads to occurring the problem of addiction as well as the use of psychoactive substances as a serious hazard to road users. The Regulation of the Minister of Health on agents acting similarly to alcohol and the conditions and manner of conducting research on their presence in the human body, requires adequate benchmarks for performing these tests. An importantfactor, from consultative point of view, is the knowledge of the chemical structure of substances belonging to different groups of drugs of abuse, their m

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Mohammed, Navaziya. "HPLC Hyphenations in Advanced Analytical World." Journal of Physical Chemistry & Biophysics 12, no. 2 (2022): 5. https://doi.org/10.5281/zenodo.14604252.

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Traditional analytical approaches of HPLC found to be insufficient for solving upcoming challenges in species specificity and sensitivity analysis. Modern analytical hybrid techniques which are referred as hyphenations have been introduced from the traditional techniques to overcome the challenges in the analysis of components. Hyphenated approaches combine separation and detection procedures through the use of chromatographic and spectroscopic techniques. The various hyphenations of that are developed until now are LC-MS, LC-NMR, LC-IR, LC-DAD and it also includes multi hyphenations like LC-M

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Yun, So-Mi, Jun-Ho Jang, Il-Shik Shin, Jong-Ok Lee, and Jong-Soo Lee. "Detection of Diarrhetic Shellfish Poisons by LC-MS/MS." Journal of the Korean Society of Food Science and Nutrition 36, no. 7 (2007): 926–31. http://dx.doi.org/10.3746/jkfn.2007.36.7.926.

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Chiou, Ling Jan, Tai Sheng Yeh, and Jiing Chuan Chen. "LC-MS/MS method for the detection of multiple classes of shellfish toxins." Czech Journal of Food Sciences 37, No. 3 (2019): 173–79. http://dx.doi.org/10.17221/125/2018-cjfs.

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Marine shellfish toxins are seafood safety problems of global concern. Herein the analysis of six shellfish toxins, regulated by European Union, with one single run by LC-MS/MS with acidic mobile phase was developed. After 80% methanol extraction of the shellfish toxins, the crude extract was subjected to HLB SPE cleanup before LC-MS/MS analysis. The method was validated according to Commission Decision 2002/657/EC. For azaspiracid-1 (AZA1), domoic acid (DA), dinophysistoxin-1 (DTX1), okadaic acid (OA), pectenotoxin-2 (PTX2), and yessotoxin (YTX) toxins the recovery rate was 99.4, 92.7, 114.1,

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Dello, Simon A. W. G., Hans M. H. van Eijk, Evelien P. J. G. Neis, Mechteld C. de Jong, Steven W. M. Olde Damink, and Cornelis H. C. Dejong. "Ophthalmate detection in human plasma with LC–MS–MS." Journal of Chromatography B 903 (August 2012): 1–6. http://dx.doi.org/10.1016/j.jchromb.2012.06.023.

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Krajčová, A., V. Schulzová, J. Lojza, L. Křížová, and J. Hajšlová. "Phytoestrogens in bovine plasma and milk – LC-MS/MS analysis." Czech Journal of Food Sciences 28, No. 4 (2010): 264–74. http://dx.doi.org/10.17221/138/2010-cjfs.

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Phytoestrogens belong to a group of polyphenolic plant metabolites which induce biological responses, based on their structural similarity to 17&beta;-estradiol. In order to investigate the relationship between the levels of these biologically active compounds and beneficial health effects, it is neccesary to quantify accurately their levels in foods and biological fluids. In this study, HPLC-MS/MS method for the determination of isoflavones genistein, daidzein, and estrogenic metabolite-equol in bovine plasma and milk was optimised and validated. The method allowed low limits of detection

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Kahl, Kristin W., Joshua Z. Seither, and Lisa J. Reidy. "LC-MS-MS vs ELISA: Validation of a Comprehensive Urine Toxicology Screen by LC-MS-MS and a Comparison of 100 Forensic Specimens." Journal of Analytical Toxicology 43, no. 9 (2019): 734–45. http://dx.doi.org/10.1093/jat/bkz066.

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Abstract Toxicology laboratories commonly employ immunoassay methodologies to perform an initial drug screen on urine specimens to direct confirmatory testing. Due to limitations of immunoassay testing and the need to screen for a broader range of drugs with lower limits of detection at a lower cost, mass spectrometry screening techniques have gained favor in the toxicology field. A liquid chromatography–tandem mass spectrometry (LC-MS-MS) urine screening panel was developed and validated for 52 drugs and metabolites. A simple dilute-and-shoot with enzymatic hydrolysis technique was utilized t

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Esquivel, Argitxu, Oscar J. Pozo, Lorena Garrostas, et al. "LC-MS/MS detection of unaltered glucuronoconjugated metabolites of metandienone." Drug Testing and Analysis 9, no. 4 (2016): 534–44. http://dx.doi.org/10.1002/dta.1996.

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Downs, Melanie L., and Philip Johnson. "Target Selection Strategies for LC-MS/MS Food Allergen Methods." Journal of AOAC INTERNATIONAL 101, no. 1 (2018): 146–51. http://dx.doi.org/10.5740/jaoacint.17-0404.

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Abstract The detection and quantitation of allergens as contaminants in foods using MS is challenging largely due to the requirement to detect proteins in complex, mixed, and often processed matrixes. Such methods necessarily rely on the use of proteotypic peptides as indicators of the presence and amount of allergenic foods. These peptides should represent the allergenic food in question in such a way that their use is both sensitive (no false-negatives) and specific (no false-positives). Choosing such peptides to represent food allergens is beset with issues, including, but not limited to, s

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Weinmann, W., M. Bohnert, A. Wiedemann, M. Renz, N. Lehmann, and S. Pollak. "Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS." International Journal of Legal Medicine 114, no. 4-5 (2001): 252–58. http://dx.doi.org/10.1007/s004140000178.

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Dewi, Kifayati Rosiyanti, Feri Kusnandar, Nancy Dewi Yuliana, et al. "Application of LC-MS/MS Coupled with Various Digestion Methods for the Identification of Porcine Gelatin Markers in Confectionery Matrices." Indonesian Journal of Halal Research 5, no. 2 (2023): 53–66. http://dx.doi.org/10.15575/ijhar.v5i2.21191.

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Gelatin is a high-risk ingredient in terms of its halal status. Liquid chromatography combined with mass spectrometry (LC-MS/MS) was used to identify the source of gelatin based on marker peptides and proved to deliver higher reliability than other methods. However, the digestion method is essential before LC-MS/MS analysis. This research evaluated different digestion methods against selected porcine gelatin marker peptides and assessed LC-MS/MS sensitivity through adulteration experiments in various mixed matrices. The study involved three digestion methods (conventional, microwave, and ultra

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Zrzavy, Tobias, Alice Wielandner, Lukas Haider, et al. "FLAIR2 post-processing: improving MS lesion detection in standard MS imaging protocols." Journal of Neurology 269, no. 1 (2021): 461–67. http://dx.doi.org/10.1007/s00415-021-10833-x.

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Abstract Background Technical improvements in magnetic resonance imaging (MRI) acquisition, such as higher field strength and optimized sequences, lead to better multiple sclerosis (MS) lesion detection and characterization. Multiplication of 3D-FLAIR with 3D-T2 sequences (FLAIR2) results in isovoxel images with increased contrast-to-noise ratio, increased white–gray-matter contrast, and improved MS lesion visualization without increasing MRI acquisition time. The current study aims to assess the potential of 3D-FLAIR2 in detecting cortical/leucocortical (LC), juxtacortical (JC), and white mat

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Venkateshwarlu, Punna, and Mehul M. Patel. "Method development and validation of cabozantinib by LC-MS/MS." Pharmacia 69, no. (2) (2022): 407–13. https://doi.org/10.3897/pharmacia.69.e82684.

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The objective of this method is to be simple, precise, and economical performed by LC-MS/MS instrument. The mass spectrometric determination was performed using electrospray ionization in the positive mode with multiple reaction monitoring (MRM) mode and precursor to product ion transition to product ion of m/z 502.2 > 323 for cabozantinib. The effective separation of cabozantinib was achieved X-Bridge (2.1 mm × 100 mm, 3.5 µ) column and the mobile phase composition is 0.2% formic acid: acetonitrile (40:60 v/v), pumped at 0.12 ml/min flow rate. The Rt of cabozantinib was found to be 1.34 mi

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Balas, Laurence, Justine Bertrand-Michel, Fanny Viars, et al. "Regiocontrolled syntheses of FAHFAs and LC-MS/MS differentiation of regioisomers." Organic & Biomolecular Chemistry 14, no. 38 (2016): 9012–20. http://dx.doi.org/10.1039/c6ob01597b.

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Dmitrovic, Jasna, and David A. Durden. "Analysis of Fumagillin in Honey by LC-MS/MS." Journal of AOAC INTERNATIONAL 96, no. 3 (2013): 687–95. http://dx.doi.org/10.5740/jaoacint.12-174.

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Abstract An LC/MS/MS method has been optimized and validated for the quantification and confirmation of fumagillin in honey. Fumagillin is isolated and concentrated by RP polymeric SPE. Final extracts are analyzed using electrospray ionization LC/MS/MS in positive mode with a formic acid and ammonium formate–acetonitrile mobile phase. Method uncertainty was determined using two analytical systems from different manufacturers. The validation of this LC/MS/MS method for the detection of fumagillin demonstrated overall recovery of 99.3%, precision of 5.9%, expanded uncertainty of 13.2%, and LOD o

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Zhang, Kai. "Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A." Toxins 13, no. 8 (2021): 547. http://dx.doi.org/10.3390/toxins13080547.

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Two methods for measuring ochratoxin A in corn, oat, and grape juice were developed and compared. Flow injection (FI) and on-line liquid chromatography (LC) performances were evaluated separately, with both methods using a triple quadrupole tandem mass spectrometer (MS/MS) for quantitation. Samples were fortified with 13C uniformly labeled ochratoxin A as the internal standard (13C-IS) and prepared by dilution and filtration, followed by FI- and LC-MS/MS analysis. For the LC-MS/MS method, which had a 10 min run time/sample, recoveries of ochratoxin A fortified at 1, 5, 20, and 100 ppb in corn,

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Riswahyuli, Riswahyuli, Loise RS, and Niza Nemara. "Multi Mycotoxins Analysis in Rice Using LC-MS/MS." MPI (Media Pharmaceutica Indonesiana) 1, no. 2 (2017): 77–84. http://dx.doi.org/10.24123/mpi.v1i2.189.

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Multi mycotoxins analysis in this research has the purpose to develop method of analysisfor rice sample with a simple and fast preparation and novel technology using LC-MS/MS. Several blankrice samples were spiked with standards of 8 classes of mycotoxins (Aflatoxin B1, Aflatoxin B2, AflatoxinG1, Aflatoxin G2, Deoxynivalenol, Zearalenon, T-2, and HT-2). Parameter of linearity, precision, recovery,limit of detection and limit of quantification were obtained and calculated. The result shows that all thevalidation parameters comply with criteria of method validation. Sonication method that was ch

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Hoefig, Carolin Stephanie, and Josef Köhrle. "LC–MS/MS detection of thyroid hormone metabolites in tissue samples." Expert Review of Endocrinology & Metabolism 7, no. 5 (2012): 511–13. http://dx.doi.org/10.1586/eem.12.48.

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19

EL-Helbawy, S. M. "Detection of benzodiazepines in hair by FPIA and LC–MS–MS." Toxicology Letters 205 (August 2011): S200. http://dx.doi.org/10.1016/j.toxlet.2011.05.688.

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Eghlimi, Ryan, Xiaojian Shi, Jonathan Hrovat, Bowei Xi, and Haiwei Gu. "Triple Negative Breast Cancer Detection Using LC–MS/MS Lipidomic Profiling." Journal of Proteome Research 19, no. 6 (2020): 2367–78. http://dx.doi.org/10.1021/acs.jproteome.0c00038.

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21

Wang, Jinglan, Yangjun Zhang, Hong Jiang, Yun Cai, and Xiaohong Qian. "Phosphopeptide detection using automated online IMAC-capillary LC-ESI-MS/MS." PROTEOMICS 6, no. 2 (2006): 404–11. http://dx.doi.org/10.1002/pmic.200500223.

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Wang, Jinglan, Yangjun Zhang, Hong Jiang, Yun Cai, and Xiaohong Qian. "Phosphopeptide detection using automated online IMAC-capillary LC-ESI-MS/MS." PROTEOMICS 6, no. 4 (2006): 1371. http://dx.doi.org/10.1002/pmic.200690023.

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Akbaba, Murat, and Aysun Baransel Isir. "Concordance of Biochip-Based and LC-MS/MS Methods in Urine and Blood Samples in Screening for Amphetamine and Methamphetamine." Diagnostics 15, no. 3 (2025): 269. https://doi.org/10.3390/diagnostics15030269.

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Objectives: This study aimed to evaluate the efficacy and reliability of LC-MS/MS and biochip-based screening in detecting narcotics from blood and urine samples. Materials and Methods: In this single-center study, a total of 250 subjects provided urine and/or blood samples: 234 provided urine and blood samples, and 16 provided only blood samples. Biochip-based narcotics screening was performed on 234 urine and 16 blood samples, and all samples were analyzed using tandem liquid chromatography-mass spectrometry (LC-MS/MS). Results: The two most prevalent narcotics were methamphetamine and amphe

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Heick, Julia, Markus Fischer, Sandra Kerbach, Ulrike Tamm, and Bert Popping. "Application of a Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Detection of Seven Allergenic Foods in Flour and Bread and Comparison of the Method with Commercially Available ELISA Test Kits." Journal of AOAC INTERNATIONAL 94, no. 4 (2011): 1060–68. http://dx.doi.org/10.1093/jaoac/94.4.1060.

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Abstract To protect the allergic consumer, analytical methods need to be capable of detecting allergens in fnished products that typically contain multiple allergens. An LC/MS/MS method for simultaneous detection of seven allergens was developed and compared with commercially available ELISA kits. The detection capabilities of this novel method were demonstrated by analyzing incurred material containing milk, egg, soy, peanut, hazelnut, walnut, and almond. Bread was chosen as a model matrix. To assess the inﬂuence of baking on the method’s performance, analysis was done before and after baking

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Trip, Hein, Katrin Mende, Joanna A. Majchrzykiewicz-Koehorst та ін. "Simultaneous Identification of Multiple β-Lactamases in Acinetobacter baumannii in Relation to Carbapenem and Ceftazidime Resistance, Using Liquid Chromatography-Tandem Mass Spectrometry: TABLE 1". Journal of Clinical Microbiology 53, № 6 (2015): 1927–30. http://dx.doi.org/10.1128/jcm.00620-15.

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Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect β-lactamases in clinicalAcinetobacter baumanniiisolates. The correlation of the detection of β-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS in antimicrobial susceptibility testing.

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Mahmoud A. Alabdalla and Abdelqader S. As’ad. "Analysis of Drugs of Abuse in Hair Sample by LC/MS-MS." Indian Journal of Forensic Medicine & Toxicology 19, no. 2 (2025): 67–74. https://doi.org/10.37506/668rky88.

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Due to its prolonged detection window, hair has become an important material for drug analysis. It is suitable for the detection of frequent drug abuse (DOA) dependence and other toxicological considerations. The advancement in chromatographic techniques especially liquid chromatography-tandem mass spectrometry (LC/MS-MS) makes detecting even traces of a drug in hair possible. Therefore, LC/MS-MS is progressively replacing gas chromatographic techniques as a tool for screening and confirmation making it the method of choice for hair analysis. In the present study, a method to determine common

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T. Farmaan, C. Hima Bindu, and T. Reshma. "LC-MS in Proteomics and Biomarker Discovery." International Journal of Science and Research Archive 14, no. 3 (2025): 900–913. https://doi.org/10.30574/ijsra.2025.14.3.0753.

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Liquid chromatography-mass spectrometry (LC-MS) has emerged as a powerful analytical tool in the field of proteomics and biomarker discovery. LC-MS combines the high separation efficiency of liquid chromatography (LC) with the sensitive and specific detection capabilities of mass spectrometry (MS), enabling the identification and quantification of complex protein mixtures in biological samples. In proteomics, LC-MS facilitates the characterization of post-translational modifications, protein-protein interactions, and differential protein expression in health and disease states. The technique's

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Vuković, Gorica, Vojislava Bursić, Tijana Stojanović, et al. "LC-MS/MS Determination of Tropane Alkaloids in Maize Crop." Contemporary Agriculture 67, no. 3-4 (2018): 221–26. http://dx.doi.org/10.1515/contagri-2018-0032.

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Summary The undemanding LC-MS/MS method was developed for the synchronized analysis of atropine and scopolamine in maize crop. The dSPE was carried out with 1% acetic acid in acetonitrile/water and a mixture of magnesium sulphate, sodium chloride and sodium citrate. The analytes were separated on a Zorbax XDB C18 column using methanol/water as the mobile phase in gradient mode. The detection was done using a tandem masss spectrometry (MS/MS) in the positive ESI. The tropane alkaloids exhibited excellent linearity in the range of 2-20 µg/kg with the LOQ of 5 µg/kg for maize. The extraction reco

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Netzel, Brian C., Kendall W. Cradic, Eric T. Bro, et al. "Increasing Liquid Chromatography–Tandem Mass Spectrometry Throughput by Mass Tagging: A Sample-Multiplexed High-Throughput Assay for 25-Hydroxyvitamin D2 and D3." Clinical Chemistry 57, no. 3 (2011): 431–40. http://dx.doi.org/10.1373/clinchem.2010.157115.

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BACKGROUND The limits of chromatographic speed and mechanical frontend capabilities have been reached for many high-volume liquid chromatography–tandem mass spectrometry (LC-MS/MS) tests, curtailing the maximal achievable sample throughput. To overcome these boundaries, we developed and validated a derivatization-based sample-multiplex LC-MS/MS assay for detection of 25-hydroxyvitamins D2 and D3 [25(OH)D2 and 25(OH)D3], which increased sample throughput 5-fold. METHODS After separate derivatization with 1 of 5 different triazoline-diones (TADs), 5 calibrators, controls, or patient specimens we

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Grocholska, Paulina, Andrzej Konieczny, Zuzanna Kaźmierczak, et al. "Peptide Charge Derivatization as a Tool for Early Detection of Preeclampsia by Mass Spectrometry—A Comparison with the ELISA Test." Molecules 26, no. 23 (2021): 7102. http://dx.doi.org/10.3390/molecules26237102.

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Early detection of any preeclampsia biomarkers may lower the risk of mortality, both for a mother and a child. Our study focuses on techniques for preeclampsia biomarker identification by comparing the results of a method using liquid chromatography mass spectrometry in multiple reaction monitoring mode (LC-MS/MS) with those by the enzyme-linked immunosorbent assay (ELISA) test, as well as by comparing the obtained results with clinical data. In the proposed LC-MS/MS method a tryptic digest peptide charge derivatization strategy was used as a tool for sensitive detection of podocin, i.e., a pr

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Zhao, Yuwen, Jerry Cao, Yuan-Shek Chen, et al. "Detection of tetrahydrobiopterin by LC–MS/MS in plasma from multiple species." Bioanalysis 1, no. 5 (2009): 895–903. http://dx.doi.org/10.4155/bio.09.77.

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Lock, Stephen. "Gluten Detection and Speciation by Liquid Chromatography Mass Spectrometry (LC-MS/MS)." Foods 3, no. 1 (2013): 13–29. http://dx.doi.org/10.3390/foods3010013.

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Iancu, Vasile Ion, Toma Galaon, Marcela Niculescu, and Carol Blaziu Lehr. "Neonicotinoids Detection by new LC-MS/MS Method in Romanian Surface Waters." Revista de Chimie 68, no. 8 (2017): 1716–22. http://dx.doi.org/10.37358/rc.17.8.5751.

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Increasing and widespread use of neonicotinoid insecticides in all world, together with their highly toxicity to invertebrates and environmental persistence mean that surface waters need to be monitored for these compounds. In the 2015, neonicotinoid insecticides have been incorporated in the watch list of substances for a European Union monitoring program (495/2015/ EU). A new method using automated solid phase extraction (SPE) with polymeric cartridges (OASIS HLB) followed by LC-MS/MS provided good separation of the most common neonicotindoid compounds. The method was developed for the deter

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Miller, E. I., F. M. Wylie, and J. S. Oliver. "Detection of Benzodiazepines in Hair Using ELISA and LC-ESI-MS-MS." Journal of Analytical Toxicology 30, no. 7 (2006): 441–48. http://dx.doi.org/10.1093/jat/30.7.441.

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Althaus, John S., Kari R. Schmidt, Scott T. Fountain, et al. "LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels." Free Radical Biology and Medicine 29, no. 11 (2000): 1085–95. http://dx.doi.org/10.1016/s0891-5849(00)00350-6.

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Kaufmann, Eckhard, and Andreas Alt. "Detection of ethyl glucuronide in dried human blood using LC-MS/MS." International Journal of Legal Medicine 122, no. 3 (2008): 245–49. http://dx.doi.org/10.1007/s00414-007-0219-x.

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Pitt, J. J. "Improving the detection of inborn errors of metabolism using LC–MS/MS." Clinica Chimica Acta 411, no. 11-12 (2010): 906. http://dx.doi.org/10.1016/j.cca.2010.02.038.

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Ketha, Hemamalini, Rajiv Kumar, and Ravinder J. Singh. "LC-MS/MS for Identifying Patients with CYP24A1 Mutations." Clinical Chemistry 62, no. 1 (2016): 236–42. http://dx.doi.org/10.1373/clinchem.2015.244459.

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Abstract BACKGROUND Patients have been described with loss-of-function CYP24A1 (cytochrome P450, family 24, subfamily A, polypeptide 1) mutations that cause a high ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D [25(OH)D/24,25(OH)2D], increased serum 1,25-dihydroxyvitamin D, and resulting hypercalcemia, hypercalciuria and nephrolithiasis. A 25(OH)D/24,25(OH)2D ratio that can identify patients who are candidates for confirmatory CYP24A1 genetic testing would be valuable. We validated an LC-MS/MS assay for 24,25(OH)2D (D3 and D2) and determined a 25(OH)D/24,25(OH)2D cutoff to identify c

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Rutuja, V. Pagare, and Phadtare Dipti. "An Overview of The Hyphenated Separation Technology and its Application in the Pharmacy." Int. J. in Pharm. Sci. 1, no. 1 (2021): 1–11. https://doi.org/10.5281/zenodo.5483833.

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Traditional analytical approaches, including high performance liquid chromatography (HPLC), gas chromatography (GC), and ultraviolet (UV) detection, cannot effectively address the emerging problems of species specificity and sensitivity analysis. A modern analytical technique called transferring is depend upon the traditional use of specific detection of molecules or elements in electrophoresis or chromatography. Currently, the most common methods for the estimation of trace elements include a combination of separation methods and more sensitive detection methods. Previously, this binding meth

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Stout, Steven J., Enaksha Wickremesinhe, Adrian R. daCunha, and Alisa Khunachak. "Confirmation of Moxidectin Residues in Cattle Fat by Liquid Chromatography/Mass Spectrometry." Journal of AOAC INTERNATIONAL 83, no. 6 (2000): 1446–50. http://dx.doi.org/10.1093/jaoac/83.6.1446.

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Abstract Moxidectin, a potent new endo- and ectoparasitic agent, is determined in cattle tissues by liquid chromatography (LC) with fluorescence detection. The original confirmatory method for moxidectin in cattle fat, the target tissue for regulatory purposes, was LC with mass spectrometry (MS) using thermospray (TSP) ionization and selected ion monitoring. As newer ionization techniques for LC/MS made TSP obsolete and with the availability of a new generation of benchtop LC/MS instrumentation, the confirmation of moxidectin in cattle fat was re-evaluated. The ionization techniques of atmosph

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Lowe, Rachel, Eden P. Go, Grace C. Tong, Nicolas H. Voelcker, and Gary Siuzdak. "Monitoring EDTA and endogenous metabolite biomarkers from serum with mass spectrometry." Spectroscopy 19, no. 3 (2005): 137–46. http://dx.doi.org/10.1155/2005/428672.

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We describe a quantitative method for the determination of ethylenediaminetetraacetic acid (EDTA) in human serum by gas chromatography mass spectrometry (GC-MS), liquid chromatography electrospray ionisation tandem mass spectrometry (LC-ESI-MS/MS), and desorption ionisation on silicon mass spectrometry (DIOS-MS). In the initial stages of the analysis, endogenous metabolites (1-palmitoyl-sn-glycero-3-phosphocholine and 1-stearoyl-sn-glycero-3-phosphocholine) were readily observed in LC-ESI-MS and DIOS-MS however, direct analysis of the EDTA free acid had limited sensitivity. In order to improve

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Mahabee-Gittens, E. Melinda, Matthew J. Mazzella, John T. Doucette, et al. "Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children." International Journal of Environmental Research and Public Health 17, no. 4 (2020): 1157. http://dx.doi.org/10.3390/ijerph17041157.

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Objective: Cotinine is the preferred biomarker to validate levels of tobacco smoke exposure (TSE) in children. Compared to enzyme-linked immunosorbent assay methods (ELISA) for quantifying cotinine in saliva, the use of liquid chromatography tandem mass spectrometry (LC-MS/MS) has higher sensitivity and specificity to measure very low levels of TSE. We sought to compare LC-MS/MS and ELISA measures of cotinine in saliva samples from children overall and the associations of these measures with demographics and TSE patterns. Method: Participants were nonsmoking children (N = 218; age mean (SD) =

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Patel, Nirali G., D. A. Dhale, and Mayuri C. Rathod. "Analysis of Pesticide Residue in Fruit Using the QuEChERS Method Coupled With LC-MS/MS Detection." Current Agriculture Research Journal 12, no. 2 (2024): 865–72. http://dx.doi.org/10.12944/carj.12.2.29.

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Identifying pesticide residues in fruits is essential to both regulatory compliance and food safety. For this use, liquid chromatography combined with tandem mass spectrometry, or liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), is an advanced analytical method that provides excellent sensitivity and specificity. This work offers a thorough procedure for employing LC-MS/MS to extract, clean up, and quantify various pesticide residues in fruit samples.The QuEChERS technique, which uses acetonitrile and a salting-out step for effective partitioning, first homogenizes the fru

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Pang, Bingyao, Ying Zhu, Longqing Lu, Fangbing Gu, and Hailong Chen. "The Applications and Features of Liquid Chromatography-Mass Spectrometry in the Analysis of Traditional Chinese Medicine." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/3837270.

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With increasingly improved separation of complex samples and detection of unknown material capabilities, liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in traditional Chinese medicine (TCM) research. This article describes the principles of liquid chromatography (LC) and mass spectrometry (MS) and their advantages and disadvantages in qualitative and quantitative analysis of TCM. We retrieved research literatures about the application of LC-MS in TCM published during the past five years at home and abroad. To better guide the analysis of TCM, this review main

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Vaiano, Fabio, Giovanni Serpelloni, Martina Focardi, Alessia Fioravanti, Francesco Mari, and Elisabetta Bertol. "LC–MS/MS and GC–MS methods in propofol detection: Evaluation of the two analytical procedures." Forensic Science International 256 (November 2015): 1–6. http://dx.doi.org/10.1016/j.forsciint.2015.07.013.

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Moldoveanu, Serban C., Thomas Poole, and Wayne A. Scott. "An LC-MS Method for the Analysis of Some Organic Acids in Tobacco Leaf, Snus, and Wet Snuff." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 28, no. 1 (2018): 30–41. http://dx.doi.org/10.2478/cttr-2018-0004.

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SummaryThe present study describes the analysis of several organic acids in tobacco and smokeless tobacco products using a liquid chromatography (LC) method with mass spectrometric (MS) detection (LC-MS). Prior to the application of the LC-MS method, a qualitative analysis for the identification of the organic acids in tobacco and oral tobacco products was performed. The qualitative method used direct silylation of the plant material followed by GC-MS separation and detection. For the acids’ quantitation, a novel LC-MS method has been developed and validated. The acids of interest for quantita

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da Mota Castelo Branco, Daniel, Noely Camila Tavares Cavalcanti Bedor, Carolina Santos Silva, Danilo César Galindo Bedor, Maria Fernanda Pimentel, and Davi Pereira de Santana. "Quality by design applied to olanzapine and quetiapine LC-MS/MS bioanalysis." Journal of Chromatographic Science 58, no. 2 (2020): 117–26. http://dx.doi.org/10.1093/chromsci/bmz083.

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Abstract One major challenge in quantifying drugs in biological matrices is to manage interfering compounds. A technique such liquid chromatography coupled to mass spectrometry in tandem (LC-MS/MS) is especially suitable for this application due to its high sensitivity and selectivity in detecting low concentrations of analytes in a complex system. Due to the complexity of LC-MS/MS systems, a number of experimental parameters must be optimized to provide an adequate separation and detection of the analyte. In the present work, a design of experiments approach was developed to optimize an LC-MS

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Beyer, Jochen, Frank T. Peters, Thomas Kraemer, and Hans H. Maurer. "Detection and validated quantification of toxic alkaloids in human blood plasma—comparison of LC-APCI-MS with LC-ESI-MS/MS." Journal of Mass Spectrometry 42, no. 5 (2007): 621–33. http://dx.doi.org/10.1002/jms.1191.

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Zhang, Zhi-Yi. "LC/MS/MS warfarin assay − An emerging tool for the early detection of cytochrome P450-associated drug−drug interactions in drug discovery." Spectroscopy 17, no. 2-3 (2003): 491–502. http://dx.doi.org/10.1155/2003/285309.

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The LC/MS/MS warfarin assay, combining stereo- and regioselective cytochrome P450 (CYP) form-specific warfarin hydroxylation with sensitive and specific LC/MS/MS detection technique, is emerging to be a promising tool for the study of CYP-associated drug−drug interactions for new chemical entities (NCEs) during drug discovery process.

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Klijnstra, Mirjam, and Arjen Gerssen. "A Sensitive LC-MS/MS Method for Palytoxin Using Lithium Cationization." Toxins 10, no. 12 (2018): 537. http://dx.doi.org/10.3390/toxins10120537.

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Palytoxin (PlTX) and analogues are produced by certain dinoflagellates, sea anemones, corals and cyanobacteria. PlTX can accumulate in the food chain and when consumed it may cause intoxication with symptoms like myalgia, weakness, fever, nausea, and vomiting. The analysis of PlTXs is challenging, and because of the large molecular structure, it is difficult to develop a sensitive and selective liquid chromatography-mass spectrometry (LC-MS/MS) method. In this work, an LC-MS/MS method was developed to analyse PlTXs with use of lithium iodine and formic acid as additives in the mobile phase. Fo

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