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Journal articles on the topic 'LDV'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

van den Broek, M. F., R. Spörri, C. Even, et al. "Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity." Journal of Immunology 159, no. 4 (1997): 1585–88. http://dx.doi.org/10.4049/jimmunol.159.4.1585.

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Abstract Viruses have developed various strategies to coexist with vertebrate hosts. Lactate dehydrogenase-elevating virus (LDV) is a highly cytopathic virus exhibiting an extraordinary rate of replication; LDV nevertheless establishes a persistent infection without harming the host. The cytotoxic and helper T cell responses to LDV were monitored in mice with different genetic backgrounds. LDV-specific cytotoxic and helper T cells were found in all strains tested. These responses persisted for at least up to 250 days despite high levels of LDV in the blood. Thus, the cytopathic LDV induces and

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2

Stokes, William, Carol Fenton, Fiona Clement, Matthew James, Paul Ronksley, and Karen L. Tang. "The Efficacy and Safety of 12 Weeks of Sofosbuvir and Ledipasvir versus Sofosbuvir, Ledipasvir, and Ribavirin in Patients with Chronic Hepatitis C, Genotype 1, Who Have Cirrhosis and Have Failed Prior Therapy: A Systematic Review and Meta-Analysis." Canadian Journal of Gastroenterology and Hepatology 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/6468309.

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Background.The recommended therapy for patients with chronic hepatitis C (CHC), genotype 1, who have cirrhosis and have failed prior therapy is 12 weeks of sofosbuvir (SOF), ledipasvir (LDV), and ribavirin (RBV). This recommendation is based on expert opinion, and the efficacy of 12 weeks of SOF/LDV compared to SOF/LDV/RBV in this patient population has not yet been established.Methods. We conducted a systematic review and meta-analysis. Two investigators independently searched electronic databases and relevant conference proceedings for randomized controlled trials comparing rates of sustaine

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Plagemann, Peter G. W., Quentin A. Jones, and William A. Cafruny. "N-Glycans on the short ectodomain of the primary envelope glycoprotein play a major role in the polyclonal activation of B cells by lactate dehydrogenase-elevating virus." Journal of General Virology 81, no. 9 (2000): 2167–75. http://dx.doi.org/10.1099/0022-1317-81-9-2167.

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The common biologically cloned isolates of lactate dehydrogenase-elevating virus (LDV-P and LDV-vx) invariably cause a polyclonal activation of B cells in immunocompetent mice. It is recognized by an at least 10-fold increase in plasma IgG2a levels and the de novo formation of immune complexes that most likely consist of autoantibodies and their antigens. The present study indicates that three closely spaced N-glycans on the short ectodomain of the primary envelope glycoprotein, VP-3P, of LDV-P/vx, play a major role in inducing the polyclonal proliferation of B cells. IFN-γ then seems to media

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Kiel, J. W., G. L. Riedel, G. R. DiResta, and A. P. Shepherd. "Gastric mucosal blood flow measured by laser-Doppler velocimetry." American Journal of Physiology-Gastrointestinal and Liver Physiology 249, no. 4 (1985): G539—G545. http://dx.doi.org/10.1152/ajpgi.1985.249.4.g539.

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To determine the feasibility of measuring gastric mucosal blood flow by laser-Doppler velocimetry (LDV), we utilized two LDV flowmeters to monitor blood flow in mucosa and serosa of chambered canine stomach. In isolated, nonautoregulating gastric segments vasodilated with isoproterenol, LDV mucosal and muscularis blood flows were both linearly related to total electromagnetic blood flow during step increases in perfusion pressure. To assess the depth of the LDV measurement, we recorded reactive hyperemia following arterial occlusion. Reactive hyperemia was frequently registered in the mucosa b

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Arechvo, Irina, Nikoloz Lasurashvili, Matthias Bornitz, Zurab Kevanishvili, and Thomas Zahnert. "Laser Doppler vibrometry of the middle ear in humans: derivation dependence, variability, and bilateral differences." Medicina 45, no. 11 (2009): 878. http://dx.doi.org/10.3390/medicina45110113.

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Objective. Derivation dependence, inter- and intrasubject/intertest variability, bilateral differences of the eardrum vibration characteristics have been investigated using laser Doppler vibrometry (LDV). Material and methods. A total of 31 normally hearing adults were examined. In each subject, both ears were consecutively stimulated by the chirp acoustic stimulus that covered 500–3700-Hz frequencies. The laser beam was directed to and the reflection was consecutively picked up from the tympanic membrane surface. Results. LDV curves derived from different eardrum loci possessed dissimilar cha

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6

Cheng, Guofeng, Yang Tian, Brian Doehle, et al. "In VitroAntiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir." Antimicrobial Agents and Chemotherapy 60, no. 3 (2016): 1847–53. http://dx.doi.org/10.1128/aac.02524-15.

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Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, includingin vitropotency,in vitroresistance profile, and activity in combination with other anti-HCV agents. LDV has picomolar antiviral activity against genotype 1a and genotype 1b replicons with 50% effective concentration (EC50) values of 0.031 nM and 0.004 nM, respectively. LDV is also active against HCV genotypes 4a, 4d, 5a, and 6a with EC50values of 0.11 to 1.

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Li, Yanlu, Emiel Dieussaert, and Roel Baets. "Miniaturization of Laser Doppler Vibrometers—A Review." Sensors 22, no. 13 (2022): 4735. http://dx.doi.org/10.3390/s22134735.

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Laser Doppler vibrometry (LDV) is a non-contact vibration measurement technique based on the Doppler effect of the reflected laser beam. Thanks to its feature of high resolution and flexibility, LDV has been used in many different fields today. The miniaturization of the LDV systems is one important development direction for the current LDV systems that can enable many new applications. In this paper, we will review the state-of-the-art method on LDV miniaturization. Systems based on three miniaturization techniques will be discussed: photonic integrated circuit (PIC), self-mixing, and micro-e

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8

Robertson, Shelly J., Christoph G. Ammann, Ronald J. Messer, et al. "Suppression of Acute Anti-Friend Virus CD8+ T-Cell Responses by Coinfection with Lactate Dehydrogenase-Elevating Virus." Journal of Virology 82, no. 1 (2007): 408–18. http://dx.doi.org/10.1128/jvi.01413-07.

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ABSTRACT Friend virus (FV) and lactate dehydrogenase-elevating virus (LDV) are endemic mouse viruses that can cause long-term chronic infections in mice. We found that numerous mouse-passaged FV isolates also contained LDV and that coinfection with LDV delayed FV-specific CD8+ T-cell responses during acute infection. While LDV did not alter the type of acute pathology induced by FV, which was severe splenomegaly caused by erythroproliferation, the immunosuppression mediated by LDV increased both the severity and the duration of FV infection. Compared to mice infected with FV alone, those coinf

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9

Luchins, Kerith R., Darya Mailhiot, Betty R. Theriault, and George P. Langan. "Detection of Lactate Dehydrogenase Elevating Virus in a Mouse Vivarium Using an Exhaust Air Dust Health Monitoring Program." Journal of the American Association for Laboratory Animal Science 59, no. 3 (2020): 328–33. http://dx.doi.org/10.30802/aalas-jaalas-19-000107.

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Lactate dehydrogenase elevating virus (LDV) continues to be one of the most common contaminants of cells and cell byproducts. As such, many institutions require that tumor cell lines, blood products, and products derived or passaged in rodent tissues are free of LDV as well as other pathogens that are on institutional exclusion lists prior to their use in rodents. LDV is difficult to detect by using a live-animal sentinel health monitoring program because the virus does not reliably pass to sentinel animals. After switching to an exhaust air dust health monitoring system, our animal resources

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Casadevall, M., J. Panes, J. M. Pique, J. Bosch, J. Teres, and J. Rodes. "Limitations of laser-Doppler velocimetry and reflectance spectrophotometry in estimating gastric mucosal blood flow." American Journal of Physiology-Gastrointestinal and Liver Physiology 263, no. 5 (1992): G810—G815. http://dx.doi.org/10.1152/ajpgi.1992.263.5.g810.

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This study investigated the accuracy of laser-Doppler flowmetry (LDV) and reflectance spectrophotometry (RS) measurements as an index of blood flow in the gastric mucosa of the rat, in experimental conditions such as pharmacologically induced vasoconstriction, hypoxia, hyperoxia, and acute normovolemic anemia. Hydrogen gas clearance was used as a reference method. After vasopressin infusion, LDV signal and indexes of hemoglobin (IHb) and oxygen (ISO2) content in the gastric mucosa estimated by RS significantly decreased in parallel with the reduction of gastric mucosal blood flow (GMBF). Neith

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Yonemura, Shinji, Lin Zhou, and Frank E. Talke. "An Investigation of Slider Vibrations in Near Contact Recording Using a Digital Laser Doppler Vibrometer." Journal of Tribology 125, no. 3 (2003): 571–75. http://dx.doi.org/10.1115/1.1540124.

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At a flying height of 10 nanometers, contacts between slider and disk are likely to occur, and control of contact-induced slider vibrations is an important design consideration. In this study, slider vibrations during contact are investigated using a digital laser Doppler vibrometer (LDV). The noise level of the digital interferometer is compared with that of a conventional analog LDV. In addition, acoustic emission (AE) sensors are used to evaluate the contact behavior of the slider. A comparison of AE and LDV data is performed. The results show that the noise level of the digital LDV is lowe

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12

Kvietys, P. R., A. P. Shepherd, and D. N. Granger. "Laser-Doppler, H2 clearance, and microsphere estimates of mucosal blood flow." American Journal of Physiology-Gastrointestinal and Liver Physiology 249, no. 2 (1985): G221—G227. http://dx.doi.org/10.1152/ajpgi.1985.249.2.g221.

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In autoperfused preparations of feline jejunum, blood flow was measured from the mucosal surface with laser-Doppler velocimetry (LDV) and hydrogen gas (H2) clearance techniques while blood flow was altered by intra-arterial infusions of isoproterenol. LDV and H2 clearance estimates of blood flow were compared with total-wall and mucosal-submucosal blood flows measured with the radiolabeled microsphere technique. Over the range (26.3–73.6 ml X min-1 X 100 g-1) of blood flows attained, a series of direct linear relationships were obtained among LDV, H2 clearance, and microsphere estimates of jej

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13

Hasheminejad, Navid, Cedric Vuye, Wim Van den bergh, Joris Dirckx, and Steve Vanlanduit. "A Comparative Study of Laser Doppler Vibrometers for Vibration Measurements on Pavement Materials." Infrastructures 3, no. 4 (2018): 47. http://dx.doi.org/10.3390/infrastructures3040047.

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A laser Doppler vibrometer (LDV) is a noncontact optical measurement device to measure the vibration velocities of particular points on the surface of an object. Even though LDV has become more popular in road engineering in recent years, their signal-to-noise ratio (SNR) is strongly dependent on light scattering properties of the surface which, in some cases, needs to be properly conditioned. SNR is the main limitation in LDV instrumentation when measuring on low diffusive surfaces like pavements; therefore, an investigation on the SNR of different LDV devices on different surface conditions

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14

Huynh, Linh Quang, Hieu Sy Dau, Tien Van Tran, and Long Ba Chu. "LASER DOPPLER VELOCITY MEASUREMENT SYSTEM." Science and Technology Development Journal 13, no. 4 (2010): 84–90. http://dx.doi.org/10.32508/stdj.v13i4.2180.

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Laser Doppler Velocimetry technique (LDV) isa measuring technique which has been developed since early 1980s. LDV has many advantages such as non-invasive measurement of one or all three components of velocity vector, measured dimensional vector of velocity, high accuracy, high resolution, wide measurement range ... Commercial Equipment based on LDV principle was applied to measure flow in industrial applications, in biomedical applications, etc. ... However, most of them are the specialized equipment which have high cost. In terms of technical training and education, LDV experiment is one of

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15

Hawkins, Kelsey L., and Ives Hot. "Retrospective Cohort Study: Ledipasvir-Sofosbuvir With/Without Ribavirin for Chronic Hepatitis C Post–Liver Transplant in a Real-World Population." Journal of Pharmacy Technology 34, no. 5 (2018): 199–203. http://dx.doi.org/10.1177/8755122518782478.

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Background: Liver damage caused by hepatitis C virus (HCV) is the number one indication for liver transplantation in the United States and Europe. Patients with a detectable HCV level at time of transplant will universally develop a recurrent infection, which can lead to increased morbidity and mortality. Objective: To assess the sustained virologic response rate post end-of-treatment (SVR) in HCV-infected, post–liver transplant patients at the University of Washington Medical Center (UWMC) treated with ledipasvir-sofosbuvir (LDV/SOF). Methods: This retrospective, cohort study of HCV-positive,

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16

van den Broek, Maries F., Roman Spörri, Chen Even, et al. "Lactate dehydrogenase-elevating virus (LDV): Lifelong coexistence of virus and LDV-specific immunity." Immunology Letters 56 (May 1997): 300. http://dx.doi.org/10.1016/s0165-2478(97)86210-4.

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17

van den Broek, M. "Lactate dehydrogenase-elevating virus (LDV): Lifelong coexistence of virus and LDV-specific immunity." Immunology Letters 56, no. 1-3 (1997): 300. http://dx.doi.org/10.1016/s0165-2478(97)88048-0.

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18

Wang, Mengmeng, Fengju Zhang, Christine Carole Copruz, and Longhui Han. "First Experience in Small Incision Lenticule Extraction with the Femto LDV Z8 and Lenticule Evaluation Using Scanning Electron Microscopy." Journal of Ophthalmology 2020 (September 26, 2020): 1–8. http://dx.doi.org/10.1155/2020/6751826.

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Purpose. To evaluate the specifications and technique properties of the new Femto LDV Z8 in creating intrastromal refractive lenticules during small incision lenticule extraction (SMILE). Methods. Six enucleated porcine eyeballs were equally divided into two groups (Femto LDV Z8 or VisuMax) and were randomly assigned to three experienced refractive surgeons who performed SMILE on each group. Five intraoperative time parameters and surgeons’ satisfaction on the surgical procedure were compared between two groups. Postoperatively, the roughness of the lenticule surfaces and the irregularity of e

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Schewe, Marvin, Mohamed A. A. Ismail, Robin Zimmermann, Umut Durak, and Christian Rembe. "Flyable Mirror: Airborne laser Doppler vibrometer for large engineering structures." Journal of Physics: Conference Series 2698, no. 1 (2024): 012007. http://dx.doi.org/10.1088/1742-6596/2698/1/012007.

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Abstract Large engineering structures are subjected to extreme loads that may lead to early damage and hazards for the national economy and public safety. The laser Doppler vibrometer (LDV) has been widely used for conducting ambient vibration testing (AVT) of large structures, such as towers and historical buildings. Its superior sensitivity and the possibility to measure at hard-to-reach locations make it a versatile tool. However, two challenges limit LDV performance significantly for AVTs of large structures: (a) optically inaccessible surfaces in which the LDV beam cannot reach the spot o

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Maru, Koichi, and Yusaku Fujii. "Laser Doppler Velocimetry Using Integrated Waveguide Technology." Applied Mechanics and Materials 36 (October 2010): 323–28. http://dx.doi.org/10.4028/www.scientific.net/amm.36.323.

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Integrated laser Doppler velocimeters (LDVs) using integrated waveguide technology are reviewed. LDVs have been widely used to measure the velocity of a fluid flow or rigid object in various research and industries. However, bulk optical systems used in conventional measurement need special care from temperature change and vibration, which become the expected sources of uncertainty in measurement, due to large optical path length. Therefore, the optical system should be more compact. The LDV can be drastically reduced by using a planar lightwave circuit (PLC). The possibility for realizing sev

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Liu, Hao, Junhua Li, Duanrong Zhou, et al. "Impact of dormancy periods on some physiological and biochemical indices of potato tubers." PeerJ 11 (August 28, 2023): e15923. http://dx.doi.org/10.7717/peerj.15923.

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Background Storage of potato tubers is an essential stage of the supply chain, from farm to consumer, to efficiently match supply and demand. However, the quality and yield of potatoes are influenced by physiological changes during storage. Methods This study tested the physiological and biochemical indices in three potato varieties (YunSu 108, YunSu 304 and YunSu 306) during their dormancy periods. Results Three potato varieties with different dormancy periods were used to follow changes in starch, protein and several enzymes during storage. The starch and sugar content of the long-dormant va

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Markine-Goriaynoff, Dominique, Xavier Hulhoven, César L. Cambiaso, et al. "Natural killer cell activation after infection with lactate dehydrogenase-elevating virus." Journal of General Virology 83, no. 11 (2002): 2709–16. http://dx.doi.org/10.1099/0022-1317-83-11-2709.

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Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-γ), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced IFN-γ message expression and cytolysis, was observed. LDV triggered

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23

Shen, Peng, Chongyang Gao, Minghui Lu, Siwen Qian, Xuejun Yan, and Yao Wang. "A comparative study of non-contact acoustic emission monitoring using laser doppler vibrometer in CFRP tensile testing." Journal of Physics: Conference Series 2954, no. 1 (2025): 012084. https://doi.org/10.1088/1742-6596/2954/1/012084.

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Abstract This study aims to explore the feasibility of using a Laser Doppler Vibrometer (LDV) as a non-contact acoustic emission (AE) monitoring tool in the tensile testing of carbon fiber reinforced polymer (CFRP) composites. By comparing the performance of conventional piezoelectric AE sensors with LDV, the strengths and limitations of both techniques in damage monitoring were investigated. The experimental results show that LDV not only effectively captures high-frequency damage signals such as microcracks and fiber fractures but also exhibits significant advantages in high-frequency respon

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Antognoli, Luca, Sara Moccia, Lucia Migliorelli, Sara Casaccia, Lorenzo Scalise, and Emanuele Frontoni. "Heartbeat Detection by Laser Doppler Vibrometry and Machine Learning." Sensors 20, no. 18 (2020): 5362. http://dx.doi.org/10.3390/s20185362.

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Background: Heartbeat detection is a crucial step in several clinical fields. Laser Doppler Vibrometer (LDV) is a promising non-contact measurement for heartbeat detection. The aim of this work is to assess whether machine learning can be used for detecting heartbeat from the carotid LDV signal. Methods: The performances of Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF) and K-Nearest Neighbor (KNN) were compared using the leave-one-subject-out cross-validation as the testing protocol in an LDV dataset collected from 28 subjects. The classification was conducted on LDV sig

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Sitte, B., and C. Egbers. "LDV-measurements on baroclinic waves." Physics and Chemistry of the Earth, Part B: Hydrology, Oceans and Atmosphere 24, no. 5 (1999): 473–76. http://dx.doi.org/10.1016/s1464-1909(99)00031-3.

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26

Bischoff, Martin. "LDV/SOF im Praxistest erfolgreich." MMW - Fortschritte der Medizin 158, S2 (2016): 62. http://dx.doi.org/10.1007/s15006-016-8334-6.

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Tirabassi, Mario, and Steve J. Rothberg. "Scanning LDV using wedge prisms." Optics and Lasers in Engineering 47, no. 3-4 (2009): 454–60. http://dx.doi.org/10.1016/j.optlaseng.2008.06.003.

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Doga, A. V., I. A. Mushkova, A. N. Karimova, and E. V. Kechin. "In Vivo Histomorphologic Structure of Cornea after FemtoLASIK Using Various Femtosecond Laser Systems." Ophthalmology in Russia 15, no. 3 (2018): 264–72. http://dx.doi.org/10.18008/1816-5095-2018-3-264-272.

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Purpose:to compare in vivo histomorphologic structure of cornea after the FemtoLASIK procedure using femtolaser systems Femto Visum (Russia) and Femto LDV Z6 (Switzerland).Patients and methods:The study was carried for 70 eyes from 70 patients with low to moderate myopia after FemtoLASIK procedure. Group 1 (Femto Visum) included 36 eyes (n = 36) there the flap were formed using femtolaser Femto Visum («Optosystems», Russia), group 2 (Femto LDV Z6) included 34 eyes (n = 34) and Femto LDV Z6 was used («Ziemer Ophthalmic Systems AG», Switzerland). The excimer laser ablation was performed with Mic

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Rau, Mark, Julius O. Smith, and Doug L. James. "Augmenting a single-point laser Doppler vibrometer to perform scanning measurements." Journal of the Acoustical Society of America 151, no. 4 (2022): A157. http://dx.doi.org/10.1121/10.0010962.

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Laser Doppler vibrometers (LDV) are used for non-contact vibration measurements of various structures and are frequently used for stringed instrument measurements. Single-point LDVs can be used with the roving hammer or LDV method for mode shape measurements, but this is time-consuming and requires constant attention. Scanning LDVs exist but are expensive and often out of reach of musical acoustics researchers. An inexpensive apparatus to modify a common single-point LDV such that it can perform automated scanning measurements is presented. The augmentation consists of a mirror galvanometer, i

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Schewe, M., M. A. A. Ismail, and C. Rembe. "Towards airborne laser Doppler vibrometry for structural health monitoring of large and curved structures." Insight - Non-Destructive Testing and Condition Monitoring 63, no. 5 (2021): 280–82. http://dx.doi.org/10.1784/insi.2021.63.5.280.

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Laser Doppler vibrometry is an important sensing technology for many structural health monitoring (SHM) methods, such as modal analysis. However, when it comes to large civil structures, for example historic structures and bridges, the applicability of laser Doppler vibrometry is significantly constrained by inaccessible remote surfaces. Some of these surfaces are fully inaccessible to a ground-mounted laser Doppler vibrometer (LDV), while others are partially inaccessible, and measurements are only possible for low incident angles. Consequently, LDV measurements are either impossible or have

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Even, C., and P. G. Plagemann. "Pseudotype virions formed between mouse hepatitis virus and lactate dehydrogenase-elevating virus (LDV) mediate LDV replication in cells resistant to infection by LDV virions." Journal of virology 69, no. 7 (1995): 4237–44. http://dx.doi.org/10.1128/jvi.69.7.4237-4244.1995.

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Wayner, E. A., and N. L. Kovach. "Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin." Journal of Cell Biology 116, no. 2 (1992): 489–97. http://dx.doi.org/10.1083/jcb.116.2.489.

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It has been shown that the alpha 4 beta 1 integrin is the lymphocyte receptor for the carboxy terminal cell-binding domain of fibronectin which comprises adhesion sites in Hep 2 and a high affinity site, CS-1, in the type III connecting segment or V (for variable) region. In the present studies, using a series of peptides derived from CS-1, we identify the tripeptide leu-asp-val (LDV), as the minimal peptide capable of supporting stable lymphocyte or melanoma cell adhesion. However, only cells which expressed an active form of the alpha 4 beta 1 complex were capable of attaching to and spreadi

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Lombarde, Washington, and Neide Maria Michellan Kiouranis. "A ALQUIMIA NOS LIVROS DIDÁTICOS DE QUÍMICA APROVADOS PELO PROGRAMA NACIONAL DO LIVRO DIDÁTICO." Ensino de Ciências e Tecnologia em Revista – ENCITEC 13, no. 3 (2023): 301–29. http://dx.doi.org/10.31512/encitec.v13i3.460.

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Considerando a importância da Alquimia e seu contexto histórico, a presente pesquisa teve como objetivo compreender como a Alquimia é explorada nas obras didáticas aprovadas pelo Programa Nacional do Livro Didático (PNLD) de 2018. Trata-se de uma pesquisa de natureza qualitativa. Para análise dos livros didáticos, utilizamos como critério as marcas da historiografia tradicional apontadas por Beltran, Saito e Trindade (2014), e os livros didáticos foram identificados pelas letras LD, seguidas por um código numérico: LD1, LD2, LD3, LD4, LD5, LD6. Pela análise dos livros didáticos, identificaram-

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Kislovskiy, Yasaswi, Catherine Chappell, Emily Flaherty, et al. "Experiences and Perspectives From Women Taking Investigational Therapy for Hepatitis C Virus During Pregnancy." Substance Abuse: Research and Treatment 15 (January 2021): 117822182110462. http://dx.doi.org/10.1177/11782218211046261.

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Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy. Methods: We conducted semi-structured, in-depth interviews within an open-label, phase 1 study of LDV/SOF therapy among pregnant people with chronic HCV infection. Participants took 12 weeks of LDV/SOF and were interviewed at enrollment and again at the end of treatment. We transcribed the interviews verbatim and coded them with NVivo software for subsequent inductive thematic analysis. Results: Nine pregnant people completed

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Schwarz, S., B. Hartmann, J. Sauer, et al. "Contactless Vibrational Analysis of Transparent Hydrogel Structures Using Laser-Doppler Vibrometry." Experimental Mechanics 60, no. 8 (2020): 1067–78. http://dx.doi.org/10.1007/s11340-020-00626-0.

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Abstract Background Investigating the mechanical properties of biological and biocompatible hydrogels is important in tissue engineering and biofabrication. Atomic force microscopy (AFM) and compression testing are routinely used to determine mechanical properties of tissue and tissue constructs. However, these techniques are slow and require mechanical contact with the sample, rendering in situ measurements difficult. Objective We therefore aim at a fast and contactless method for determining the mechanical properties of biological hydrogels and investigate if an optical method, like Laser-Do

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Zheng, Haoyang, Tong Guo, Guoliang Zhi, and Zhiwei Hu. "A Novel Debonding Damage Identification Approach of Hidden Frame-Supported Glass Curtain Walls Based on UAV-LDV System." Applied Sciences 14, no. 13 (2024): 5412. http://dx.doi.org/10.3390/app14135412.

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This study introduces a novel Unmanned Aerial Vehicle-mounted (UAV-mounted) Laser Doppler Vibrometer (LDV) system for detecting debonding damage in Hidden Frame-Supported Glass Curtain Walls (HFSGCW). The established system enables UAVs to transport the LDV to high altitudes for operation. The vibration signals acquired by the UAV-LDV system are decomposed into different energy bands by wavelet packet analysis, and then the occurrence and location of the damage are identified by the Sum of Squared Differences (SSD) of the wavelet packet bands’ energy. This paper investigates the potential fact

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Wei, Jie, Karmon Vongsy, Olga Mendoza-Schrock, and Chi-Him Liu. "Vehicle Engine Classification Using Spectral Tone-Pitch Vibration Indexing and Neural Network." International Journal of Monitoring and Surveillance Technologies Research 2, no. 3 (2014): 31–49. http://dx.doi.org/10.4018/ijmstr.2014070102.

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As a non-invasive and remote sensor, the Laser Doppler Vibrometer (LDV) has found a broad spectrum of applications in various areas such as civil engineering, biomedical engineering, and even security and restoration within art museums. LDV is an ideal sensor to detect threats earlier and provide better protection to society, which is of utmost importance to military and law enforcement institutions. However, the use of LDV in situational surveillance, in particular vehicle classification, is still in its infancy due to the lack of systematic investigations on its behavioral properties. In thi

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Su, Dan, Thao Le-Thi-Phuong, and Jean-Paul Coutelier. "Modulation of lipopolysaccharide receptor expression by lactate dehydrogenase-elevating virus." Journal of General Virology 93, no. 1 (2012): 106–12. http://dx.doi.org/10.1099/vir.0.037218-0.

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Lactate dehydrogenase-elevating virus (LDV) exacerbates mouse susceptibility to endotoxin shock through enhanced tumour necrosis factor (TNF) production by macrophages exposed to lipopolysaccharide (LPS). However, the in vivo enhancement of TNF production in response to LPS induced by the virus largely exceeds that found in vitro with cells derived from infected animals. Infection was followed by a moderate increase of Toll-like receptor (TLR)-4/MD2, but not of membrane CD14 expression on peritoneal macrophages. Peritoneal macrophages from LDV-infected mice unresponsive to type I interferons (

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Gaitan, Michael, Jon Geist, Benjamin J. Reschovsky, and Ako Chijioke. "Characterization of laser Doppler vibrometers using acousto-optic modulators." ACTA IMEKO 9, no. 5 (2020): 361. http://dx.doi.org/10.21014/acta_imeko.v9i5.1001.

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We report on a new approach to characterize the performance of a laser Doppler vibrometer (LDV). The method uses two acousto-optic modulators (AOMs) to frequency shift the light from an LDV by a known quantity to create a synthetic velocity shift that is traceable to a frequency reference. Results are presented for discrete velocity shifts and for sinusoidal velocity shifts that would be equivalent to what would be observed in an ideal accelerometer vibration calibration. The method also enables the user to sweep the synthetic vibration excitation frequency to characterize the bandwidth of an

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Smedby, O¨, L. Fuchs, and N. Tillmark. "Separated Flow Demonstrated by Digitized Cineangiography Compared With LDV." Journal of Biomechanical Engineering 113, no. 3 (1991): 336–41. http://dx.doi.org/10.1115/1.2894892.

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In order to demonstrate separated flow in vivo, a method for the computerized analysis of cineangiographies has been developed, tested in vitro, and compared with LDV. A pulsatile flow was created in a glass model bifurcation, and velocity profiles were obtained with LDV at several phase angles. The flow was cinefilmed during contrast injection and the images were digitized. The computer then transformed the image sequence into parametric images representing arrival times of the contrast. The separation regions demonstrated with LDV were identified as areas with delayed contrast arrival. A pre

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Legrain, Sarah, Dan Su, Mélanie Gaignage, et al. "Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia." International Journal of Molecular Sciences 22, no. 16 (2021): 9027. http://dx.doi.org/10.3390/ijms22169027.

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Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced anemia, which suggests a protective effect of these cytokines, partly through the control of type II interferon production. The development of anemia requires the expression of Fcγ receptors (FcγR) I, III, and IV. Whereas LDV infection decreases FcγR III expression, it enhances FcγR I and IV expression

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Feng, Jianjun, F. K. Benra, and H. J. Dohmen. "Comparison of Periodic Flow Fields in a Radial Pump among CFD, PIV, and LDV Results." International Journal of Rotating Machinery 2009 (2009): 1–10. http://dx.doi.org/10.1155/2009/410838.

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The interaction between the impeller and the diffuser is considered to have a strong influence on the unsteady flow in radial pumps. In this paper, the unsteady flow in a low specific speed radial diffuser pump has been simulated by the CFD code CFX-10. Both Particle Image Velocimetry (PIV) and Laser Doppler Velocimetry (LDV) measurements have been conducted to validate the CFD results. Both the phase-averaged velocity fields and the turbulence fields obtained from different methods are presented and compared, in order to enhance the understanding of the unsteady flow caused by the relative mo

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Tanishima, K., T. Hayashi, M. Matsushima, and Y. Mochikawa. "Activity of lactate dehydrogenase isoenzymes LD1 and LD2 in serum as determined by using an inhibitor of the M-subunit." Clinical Chemistry 31, no. 7 (1985): 1175–77. http://dx.doi.org/10.1093/clinchem/31.7.1175.

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Abstract To measure activities of lactate dehydrogenase (EC 1.1.1.27) isoenzymes LD1 and LD2 in serum, we developed a method involving 1,6-hexanediol as specific inhibitor of the M-subunit. Addition of hexanediol, 0.6 mol/L, to five LD isoenzyme fractions purified from human liver and heart homogenates resulted in complete loss of activities of LD4 and LD5, and partial loss of LD2 and LD3. The activity of LD1, which is composed of the H-subunit only, was not affected. In studying what conditions would allow only the activities of LD1 or LD1 + LD2 to be expressed in serum, we found that the res

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Oyama, B. S., M. F. Andrade, P. Herckes, U. Dusek, T. Röckmann, and R. Holzinger. "Vehicular emissions of organic particulate matter in Sao Paulo, Brazil." Atmospheric Chemistry and Physics Discussions 15, no. 23 (2015): 33755–88. http://dx.doi.org/10.5194/acpd-15-33755-2015.

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Abstract. Vehicular emissions have a strong impact on air pollution in big cities. Many factors affect these emissions: type of vehicle, type of fuel, cruising velocity, and brake use. This study focused on emissions of organic compounds by Light (LDV) and Heavy (HDV) duty vehicle exhaust. The study was performed in the city of Sao Paulo, Brazil, where vehicles run on different fuels: gasoline with 25 % ethanol (called gasohol), hydrated ethanol, and diesel (with 5 % of biodiesel). The vehicular emissions are an important source of pollutants and the principal contribution to fine particulate

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Gilbert, Taidinda, Francis Olaolorun, Amany Ladagu, Funmilayo Olopade, Olumayowa Igado, and James Olopade. "Neurobehavioural and Histological Study of the Effects of Low-Dose and High-Dose Vanadium in Brain, Liver and Kidney of Mice." Nigerian Journal of Physiological Sciences 38, no. 1 (2023): 47–56. http://dx.doi.org/10.54548/njps.v38i1.8.

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Vanadium is a ubiquitous transition metal that has been generating contrasting research interest. Therapeutically, vanadium possess antidiabetic, antitumor, antiparasitic and even neuroprotective activities. On the flip side, vanadium has been reported to cause multisystemic toxicities with a strong predilection for the nervous system. Despite several reports on potential benefits of low-dose vanadium (LDV) and toxic effects of high-dose vanadium (HDV), there are no comparative studies done thus far. This study therefore explored the comparative effects of LDV and HDV exposure in mice during p

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Ivanchenko, Oleksandr, Ergin Esirgemez, and Semih Ölçmen. "A miniature three-component LDV probe." Measurement Science and Technology 18, no. 7 (2007): 2014–20. http://dx.doi.org/10.1088/0957-0233/18/7/030.

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IKEDA, Yuji, Noboru KURIHARA, and Tsuyoshi NAKAJIMA. "Burst Digital Correlator for LDV Signal Processing. 3rd Report. Burst Detection of LDV by Correlation Method." Transactions of the Japan Society of Mechanical Engineers Series B 58, no. 548 (1992): 1192–99. http://dx.doi.org/10.1299/kikaib.58.1192.

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Soe, Pyone Pyone, Mélanie Gaignage, Mohamed F. Mandour, Etienne Marbaix, Jacques Van Snick, and Jean-Paul Coutelier. "Lactate Dehydrogenase-Elevating Virus Infection Inhibits MOG Peptide Presentation by CD11b+CD11c+ Dendritic Cells in a Mouse Model of Multiple Sclerosis." International Journal of Molecular Sciences 25, no. 9 (2024): 4950. http://dx.doi.org/10.3390/ijms25094950.

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Infections may affect the course of autoimmune inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis (MS). Infections with lactate dehydrogenase-elevating virus (LDV) protected mice from developing experimental autoimmune encephalomyelitis (EAE), a mouse counterpart of MS. Uninfected C57BL/6 mice immunized with the myelin oligodendrocyte glycoprotein peptide (MOG35–55) experienced paralysis and lost weight at a greater rate than mice who had previously been infected with LDV. LDV infection decreased the presentation of the MOG peptide by CD11b+CD11c+ dendritic c

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Manning, Thomas O., Nancy A. Monteiro-Riviere, David G. Bristol, and J. Edmond Riviere. "Cutaneous laser-Doppler velocimetry in nine animal species." American Journal of Veterinary Research 52, no. 12 (1991): 1960–64. http://dx.doi.org/10.2460/ajvr.1991.52.12.1960.

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SUMMARY The assessment of cutaneous microcirculation by laser-Doppler velocimetry (ldv) has been primarily limited to human studies. The purpose of this investigation was to establish normal values in various species and anatomic sites for blood flow, velocity, and volume as determined by ldv. Microcirculation was measured with a laser-Doppler velocimeter in 54 animals, 6 healthy animals from each of 9 species. The standard sites used were the buttocks, convex surface of the ear, metacarpal pad, humeroscapular junction, thoracolumbar junction, ventral portion of the abdomen, dorsal metacarpus

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Ciancio, Alessia. "Ledipasvir/sofosbuvir: the fixed dose combination in the new era of treatment for HCV." Reviews in Health Care 6, no. 3 (2015): 87–98. http://dx.doi.org/10.7175/rhc.v6i3.1178.

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Interferon-based treatment is not suitable for many patients with hepatitis C virus (HCV) infection because of contraindications, other reasons for ineligibility and side-effects. The fixed dosed combination ledipasvir/sofosbuvir (LDV / SOF) is the first approved regimen that doesn’t require administration with interferon or ribavirin. LDV / SOF is also the first single-pill approved for the treatment of chronic HCV genotype 1 in both treatment-naïve and treatment-experienced patients. The results of the phase III studies demonstrate the combination has been very well tolerated and SVR rates c

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