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Journal articles on the topic 'Liposome structure'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Kumar, Amit, Madhu Gupta, and Simran Braya. "Liposome Characterization, Applications and Regulatory landscape in US." International Journal of Drug Regulatory Affairs 9, no. 2 (2021): 81–89. http://dx.doi.org/10.22270/ijdra.v9i2.474.

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Liposomes are lipid based drug carrier whose therapeutic performance depends on their structure. Liposomes offer several advantages over the conventional drug like target drug delivery, reduced toxicity, and extended pharmacokinetics. Characterization and Identification of critical attribute of liposomal formulation and suitable strategies for control during product development is important for quality of the liposomal drug product. This paper discusses the current status of the liposomal drug product and strategy used in regulating liposome product. Despite of lack of regulatory guidelines ma

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2

Al Badri, Yaqeen Nadheer, Cheng Shu Chaw, and Amal Ali Elkordy. "Insights into Asymmetric Liposomes as a Potential Intervention for Drug Delivery Including Pulmonary Nanotherapeutics." Pharmaceutics 15, no. 1 (2023): 294. http://dx.doi.org/10.3390/pharmaceutics15010294.

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Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic drugs) and large drug molecules (peptides, proteins, and nucleic acids). They have unique characteristics, such as a self-assembling bilayer vesicular structure. There are several FDA-approved liposomal-based medicines for treatment of cancer, bacterial, and viral infections. Most of the FDA-approved liposomal-based therapies are in the form of conventional “symmetric” liposomes and they are administered mainly by injection.

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Dhillon, Anjali, RituVinay Singh, and Kishna Ram Senwar. "An Extensive Review on Novel Liposomes : Classification, Methodology, Characterization, Current Formulations." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1842–52. http://dx.doi.org/10.25258/ijddt.14.3.83.

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Liposomes are vesicles consisting of a phospholipid, hydrophobic drug, hydrophobic tail, hydrophilic tail, cholesterol, targeting agents, positive and negatively charged lipids, and a drug encapsulated in the center of the phospholipid group having a spherical shape. The phospholipid consists of an equal number of aqueous membranes, making the liposomes an important nanocarrier for the drug delivery to the targeted site. Various liposome-based products have recently been approved and are in clinical trials. This review will discuss the structure, classification, types, and method of liposome p

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Nalawade, Vishwajit, and Kunal Patil. "Liposome: A Novel Drug Delivery System." International Journal of Research Publication and Reviews 04, no. 01 (2022): 1795–801. http://dx.doi.org/10.55248/gengpi.2023.4148.

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Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are u

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Tretiakova, Daria, Maria Kobanenko, Irina Le-Deygen, et al. "Spectroscopy Study of Albumin Interaction with Negatively Charged Liposome Membranes: Mutual Structural Effects of the Protein and the Bilayers." Membranes 12, no. 11 (2022): 1031. http://dx.doi.org/10.3390/membranes12111031.

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Liposomes as drug carriers are usually injected into the systemic circulation where they are instantly exposed to plasma proteins. Liposome–protein interactions can affect both the stability of liposomes and the conformation of the associated protein leading to the altered biodistribution of the carrier. In this work, mutual effects of albumin and liposomal membrane in the course of the protein’s adsorption were examined in terms of quantity of bound protein, its structure, liposome membrane permeability, and changes in physicochemical characteristics of the liposomes. Fluorescence spectroscop

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Mursheda*1, Ajith Chandran2 Anagha S. Raj3 Jasnath. P. "Perspectives On Liposomes: Recent Developments, Clinical Uses, And Prospects." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1073–84. https://doi.org/10.5281/zenodo.12739742.

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Liposomes are widely recognized as a significant nanoscale drug delivery method with appealing characteristics, including an easy-to-prepare bilayer structure that assembles the cellular membrane and high biocompatibility. Over the past few decades, a great deal of work has gone into developing liposome-based drug delivery systems. Numerous drug candidates have been investigated for their potential to reduce toxicity and prolong the duration of therapeutic effect by encapsulating them in liposomes. A growing number of liposomal-based therapeutics, with a variety of uses in antiviral, anticance

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Toopkanloo, Sahar Pakbaten, Tai Boon Tan, Faridah Abas, Mohammad Azam, Imededdine Arbi Nehdi, and Chin Ping Tan. "Improving Vesicular Integrity and Antioxidant Activity of Novel Mixed Soy Lecithin-Based Liposomes Containing Squalene and Their Stability against UV Light." Molecules 25, no. 24 (2020): 5873. http://dx.doi.org/10.3390/molecules25245873.

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In order to improve the membrane lipophilicity and the affinity towards the environment of lipid bilayers, squalene (SQ) could be conjugated to phospholipids in the formation of liposomes. The effect of membrane composition and concentrations on the degradation of liposomes prepared via the extrusion method was investigated. Liposomes were prepared using a mixture of SQ, cholesterol (CH) and Tween80 (TW80). Based on the optimal conditions, liposome batches were prepared in the absence and presence of SQ. Their physicochemical and stability behavior were evaluated as a function of liposome cons

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Adler-Moore, Jill, and Richard T. Proffitt. "AmBisome: liposomal formulation, structure, mechanism of action and pre-clinical experience." Journal of Antimicrobial Chemotherapy 49, suppl_1 (2002): 21–30. http://dx.doi.org/10.1093/jac/49.suppl_1.21.

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Abstract Amphotericin B is the treatment of choice for life-threatening systemic fungal infections such as candidosis and aspergillosis. To improve this drug's efficacy and reduce its acute and chronic toxicities, several lipid formulations of the drug have been developed, including AmBisome, a liposomal formulation of amphotericin B. The liposome is composed of high transition temperature phospholipids and cholesterol, designed to incorporate amphotericin B securely into the liposomal bilayer. AmBisome can bind to fungal cell walls, where the liposome is disrupted. The amphotericin B, after b

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Ayush, S. Jaiswal*1 Rekha Gaukande2 Gajanan Sanap3. "A Review On Liposomes As Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 926–36. https://doi.org/10.5281/zenodo.10442217.

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Liposomes are composed of phospholipids and lipids, forming spherical or multilayered vesicles with a lipid bilayer structure in aqueous solutions due to self-assembly of diacyl chain phospholipids. The number of bilayers and the size of vesicles influence the amount of drug encapsulation in liposomes, a crucial factor in determining their circulation half-life. This method involves coating a medication and a lipid onto a soluble carrier to create a pro-liposome, which is free-flowing and granular. When hydrated, it forms an isotonic liposomal solution. This pro-liposome approach serves as a m

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Maneri, Karishma Y* Inagle Sanjay Baride komal Latpate Manisha B. "Liposomal Nanomedicines In Cancer Therapy." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1537–52. https://doi.org/10.5281/zenodo.13997934.

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As nanocarriers, liposomes have long been studied for their ability to deliver medications to their sites of action while lowering toxicity.Nanotechnology is among the most exciting new technologies of the twenty-first century.Phospholipids give liposomes their form. Anticancer medications, among other medications, can be delivered by liposome encapsulation. Liposomes can include both hydrophilic and hydrophobic medicines. Once closed lipid bilayer vesicles were discovered, the name liposomes was first used in 1960. As medication carriers, liposomes are helpful, but making them using organic s

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Varga, Zoltán, András Wacha, and Attila Bóta. "Osmotic shrinkage of sterically stabilized liposomes as revealed by time-resolved small-angle X-ray scattering." Journal of Applied Crystallography 47, no. 1 (2014): 35–40. http://dx.doi.org/10.1107/s1600576713030513.

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Time-resolved synchrotron small-angle X-ray scattering (SAXS) was used to study the structural changes during the osmotic shrinkage of a pharmacologically relevant liposomal drug delivery system. Sterically stabilized liposomes (SSLs) with a diameter of 100 nm and composed of hydrogenated soy phosphocholine, cholesterol and distearoyl-phosphoethanolamine-PEG 2000 prepared in a salt-free buffer were mixed with a buffered 0.3 MNaCl solution using a stopped flow apparatus. The changes in the liposome size and the bilayer structure were followed by using SAXS with a time resolution of 20 ms. A lin

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Hudiyanti, Dwi, Sherllyn Meida Christa, Nur Hanna Mardhiyyah, Daru Seto Bagus Anugrah, Tatik Widiarih, and Parsaoran Siahaan. "Dynamics insights into aggregation of phospholipid species with cholesterol and vitamin C." Pharmacia 69, no. 2 (2022): 385–91. http://dx.doi.org/10.3897/pharmacia.69.e81435.

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This paper provides dynamic insight into the aggregation profile of systems containing six different phospholipid species, cholesterol, and vitamin C thru Coarse-Grain Molecular Dynamics (CGMD) simulations. The simulation used 42 systems, and each system was composed of 220 molecules of each phospholipid species, a varied number of cholesterol molecules (0, 11, 22, 33, 66, 88), and 10 vitamin C molecules. The phospholipid species were DLPE, DOPE, DLiPE, DOPS, DLiPS, and DLiPC. We found curved bilayer, toroidal bilayer, concave micelle, disc-like bilayer, planar bilayer, and liposome structures

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Hudiyanti, Dwi, Sherllyn Meida Christa, Nur Hanna Mardhiyyah, Daru Seto Bagus Anugrah, Tatik Widiarih, and Parsaoran Siahaan. "Dynamics insights into aggregation of phospholipid species with cholesterol and vitamin C." Pharmacia 69, no. (2) (2022): 385–91. https://doi.org/10.3897/pharmacia.69.e81435.

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This paper provides dynamic insight into the aggregation profile of systems containing six different phospholipid species, cholesterol, and vitamin C thru Coarse-Grain Molecular Dynamics (CGMD) simulations. The simulation used 42 systems, and each system was composed of 220 molecules of each phospholipid species, a varied number of cholesterol molecules (0, 11, 22, 33, 66, 88), and 10 vitamin C molecules. The phospholipid species were DLPE, DOPE, DLiPE, DOPS, DLiPS, and DLiPC. We found curved bilayer, toroidal bilayer, concave micelle, disc-like bilayer, planar bilayer, and liposome structures

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Roeding, J. F. "Fast imaging method for native liposomes: cryo Electron Microscopy for use in research and quality monitoring." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 744–45. http://dx.doi.org/10.1017/s0424820100155694.

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Because of their high affinity to biological membranes liposomes are used in cosmetics and pharmaceuticals. Encapsulated active agents can be transported through biological barriers into cells. Apart from chemical properties, the physical characteristics of liposomes determine their ability of penetration and resorption: Vesicle size, lamellarity (number of membranes) and homogeneity are criterias for the quality of liposome-formulations and usually can be measured with laser-light-scattering combined with e.g. NMR-spectroscopy. Classification of liposomes in type (lamellarity) and size or dif

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Hayashi, Keita, Madoka Kiriishi, Keishi Suga, Yukihiro Okamoto, and Hiroshi Umakoshi. "Investigation of Fatty Acid Ketohydrazone Modified Liposome’s Properties as a Drug Carrier." Journal of Drug Delivery 2015 (November 16, 2015): 1–7. http://dx.doi.org/10.1155/2015/481670.

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pH-responsive liposomes were prepared by modifying the liposome with acid-cleaving amphiphiles. Palmitic ketohydrazone (P-KH) or stearic ketohydrazone (S-KH), composed of hydrophilic sugar headgroup and hydrophobic acyl chain, was used as a modifier of the DMPC liposome. Because the ketohydrazone group of P-KH or S-KH was cleaved at low pH conditions (<pH 5.0), the delivery of the P-KH modified liposomes was observed probably via an endocytic pathway. The membrane properties of these liposomes were characterized, focusing on the variation of both polarity (measured by Laurdan) and membrane

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Rudolph, Alan S., and Ronald R. Price. "Video real-time imaging of artificial membranes during freeze-drying by cryo-electron microscopy." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 16–17. http://dx.doi.org/10.1017/s042482010010216x.

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We have employed cryoelectron microscopy to visualize events that occur during the freeze-drying of artificial membranes by employing real time video capture techniques. Artificial membranes or liposomes which are spherical structures within internal aqueous space are stabilized by water which provides the driving force for spontaneous self-assembly of these structures. Previous assays of damage to these structures which are induced by freeze drying reveal that the two principal deleterious events that occur are 1) fusion of liposomes and 2) leakage of contents trapped within the liposome [1].

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Zaske, Ana-María, Delia Danila, Michael C. Queen, Eva Golunski, and Jodie L. Conyers. "Biological Atomic Force Microscopy for Imaging Gold-Labeled Liposomes on Human Coronary Artery Endothelial Cells." Journal of Pharmaceutics 2013 (February 21, 2013): 1–8. http://dx.doi.org/10.1155/2013/875906.

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Although atomic force microscopy (AFM) has been used extensively to characterize cell membrane structure and cellular processes such as endocytosis and exocytosis, the corrugated surface of the cell membrane hinders the visualization of extracellular entities, such as liposomes, that may interact with the cell. To overcome this barrier, we used 90 nm nanogold particles to label FITC liposomes and monitor their endocytosis on human coronary artery endothelial cells (HCAECs) in vitro. We were able to study the internalization process of gold-coupled liposomes on endothelial cells, by using AFM.

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ENARU, Bianca, Anca FĂRCAŞ, Andreea STĂNILĂ, Sonia SOCACI, and Zoriţa DIACONEASA. "Novel Methods for Liposome Formulation: Advancements and Innovations." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology 80, no. 2 (2023): 1–13. http://dx.doi.org/10.15835/buasvmcn-fst:2023.0004.

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Liposomes are nanoscale spheroidal vesicles, predominantly composed of phospholipids, that offer a hydrophilic core surrounded by a hydrophobic bilayer. Their unique structure endows them with excellent biocompatibility and the ability to house both hydrophilic and lipophilic agents, making them exceptionally suited for targeted delivery applications. This versatility has seen liposomes gain widespread use in various industries, including medicine, pharmaceuticals, and nutraceuticals. This comprehensive review meticulously examines the spectrum of liposome fabrication techniques, providing ins

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Cevenini, Armando, Christian Celia, Stefania Orrù, et al. "Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy." Pharmaceutics 12, no. 6 (2020): 559. http://dx.doi.org/10.3390/pharmaceutics12060559.

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Mesoporous silicon microparticles (MSMPs) can incorporate drug-carrying nanoparticles (NPs) into their pores. An NP-loaded MSMP is a multistage vector (MSV) that forms a Matryoshka-like structure that protects the therapeutic cargo from degradation and prevents its dilution in the circulation during delivery to tumor cells. We developed an MSV constituted by 1 µm discoidal MSMPs embedded with PEGylated liposomes containing oxaliplatin (oxa) which is a therapeutic agent for colorectal cancer (CRC). To obtain extra-small liposomes able to fit the 60 nm pores of MSMP, we tested several liposomal

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Gao, Shuxin, Xiangzhou Yi, Xia Gao та ін. "Stabilization of β-Carotene Liposomes with Chitosan–Lactoferrin Coating System: Vesicle Properties and Anti-Inflammatory In Vitro Studies". Foods 14, № 6 (2025): 968. https://doi.org/10.3390/foods14060968.

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Liposomes serve as an effective delivery system capable of encapsulating a variety of bioactive substances. However, their structural integrity is susceptible to damage from various environmental factors, which can result in the leakage of the encapsulated bioactive agents. Consequently, identifying effective strategies to enhance the stability of liposomes has become a central focus of contemporary liposome research. Surface modification, achieved by introducing a protective layer on the liposome surface, effectively reduces liposome aggregation and enhances their stability. To this end, we d

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Amnuaikit, Thanaporn, Rajeev Shankar Rajagopal, Krisana Nilsuwan, and Soottawat Benjakul. "Enhancement of Physical Appearance, Skin Permeation, and Odor Reduction Using Liposome of Hydrolyzed Salmon Collagen for Cosmetic Products." Scientifica 2024 (April 24, 2024): 1–14. http://dx.doi.org/10.1155/2024/7843660.

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Hydrolyzed collagen (HC) derived from salmon (Oncorhynchus nerka) skin possesses properties that can nourish the skin, and it is one of the active ingredients used in cosmeceutical products for moisturizing the facial skin. However, HC solution gives off a fishy odor and it is gray in color that makes the product unacceptable for cosmetic purposes. This study aimed to use liposome-encapsulated hydrolyzed salmon collagen to improve its physical appearance, skin permeation, and eliminate the fishy odor. Two percent of HC and vitamin B3 (VitB3) were used as active ingredients to incorporate into

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Yang, Shuoye. "Preparation, in vitro Characterization and Pharmacokinetic Study of Coenzyme Q10 Long-Circulating Liposomes." Drug Research 68, no. 05 (2017): 270–79. http://dx.doi.org/10.1055/s-0043-121876.

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AbstractLong-circulating liposomal delivery systems of encapsulated Coenzyme Q10 (CoQ10), a ubiquinone anti-cataract agent, were developed with different molar ratios of PEGylated lipids and/or cholesterol. The resulting samples were contrasted through observation of morphology, analysis of particle size and Zeta potential, and in vivo pharmacokinetics. A protamine aggregation method with high selectivity was developed to determine the encapsulation efficiency (EE), after which the liposome formulation was further optimized by applying a Box Behnken design (BBD) using EE as the evaluation inde

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Wang, Zian, Yang Liu, Yifei Jiang, Peng Wang, and Min Ji. "Preparation and Characterization of Active Targeting Dual-Functionalized Liposome with Anti-Tumor Ability and Optimized Fluorescent Intensity." Journal of Nanoscience and Nanotechnology 20, no. 9 (2020): 5305–12. http://dx.doi.org/10.1166/jnn.2020.17859.

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Although the preparation of Indocyanine Green (ICG) liposomes obtained stronger performance than free ICG. With increase in depth of tissue, ICG exhibits limited background (SBR) and blurs structure characteristics. In this research, a Stearylamine-Bearing cationic liposome was prepared for improved fluorescence performance (higher SBR and deeper imaging depth). In addition, the effect of ICG and lipid interactions was explored. Hyaluronic acid is subsequently modified on the liposomes for prolonging blood circulation time and active tumor targeting. In vitro study confirmed that the liposome

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Liao, Yukun, Huiting Jiang, Yangrui Du, Xiaojing Xiong, Yu Zhang, and Zhiyu Du. "Using Convolutional Neural Network as a Statistical Algorithm to Explore the Therapeutic Effect of Insulin Liposomes on Corneal Inflammation." Computational Intelligence and Neuroscience 2022 (July 31, 2022): 1–9. http://dx.doi.org/10.1155/2022/1169438.

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Aiming at the disadvantages of easy recurrence of keratitis, difficult eradication by surgery, and easy bacterial resistance, insulin-loaded liposomes were prepared, and convolutional neural network was used as a statistical algorithm to build SD rat corneal inflammation model and study insulin-loaded liposomes, alleviating effect on corneal inflammatory structure in SD rats. The INS/PFOB@LIP was developed by means of thin-film dispersive phacoemulsification, its structure was monitored using a transmission electron microscope, particle size and appearance potential were monitored using a Malv

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Maggi, Stefano, Giulia Mori, Luigi Maglie, et al. "Activity of Membrane-Permeabilizing Lpt Peptides." Biomolecules 14, no. 8 (2024): 994. http://dx.doi.org/10.3390/biom14080994.

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Herein, we investigated the toxicity and membrane-permeabilizing capabilities of Lpt and Lpt-like peptides, belonging to type I toxin–antitoxin systems carried by plasmid DNA of Lacticaseibacillus strains. These 29 amino acid peptides are predicted to form α-helical structures with a conserved central hydrophobic sequence and differently charged hydrophilic termini. Like Lpt, the expression of Lpt-like in E. coli induced growth arrest, nucleoid condensation, and cell membrane damage, suggesting membrane interaction as the mode of action. The membrane permeabilization activity of both peptides

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Tatiara Régis, Luciana Knop, Bruna Machado, and Valter de Senna. "Liposome Drug Delivery in Cancer Chemotherapy: Review and Multifactorial Analysis." JOURNAL OF BIOENGINEERING OF AND TECCHNOLOGY applied to Health 2, no. 2 (2019): 59–69. http://dx.doi.org/10.34178/jbth.v2i2.58.

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We reviewed the use of liposomes for cancer therapy using computational biostatistics. We used virtual libraries, such as PubMed, LILACS, National Health Institute (NHI) and the Food Drug Administration (FDA) to conduct the review. Cluster analysis and correlation were developed using the Tanimoto coefficient (TC) of 0.7 using the modeling tool ChemMine Tools from databases (PubChem, DailyMed, DrugBank, Drug @ FDA). The results pointed fifteen molecules in the pharmaceutical form of liposome for the oncological clinic. Of these, 13 are classified by size into small-molecules and were analyzed

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Németh, Zsófia, Edina Pallagi, Dorina Gabriella Dobó, Gábor Kozma, Zoltán Kónya, and Ildikó Csóka. "An Updated Risk Assessment as Part of the QbD-Based Liposome Design and Development." Pharmaceutics 13, no. 7 (2021): 1071. http://dx.doi.org/10.3390/pharmaceutics13071071.

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Liposomal formulation development is a challenging process. Certain factors have a critical influence on the characteristics of the liposomes, and even the relevant properties can vary based on the predefined interests of the research. In this paper, a Quality by Design-guided and Risk Assessment (RA)-based study was performed to determine the Critical Material Attributes and the Critical Process Parameters of an “intermediate” active pharmaceutical ingredient-free liposome formulation prepared via the thin-film hydration method, collect the Critical Quality Attributes of the future carrier sy

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Tayal, Shivam, Pradyumn Tiwari, Vinod Sahu, and Shivang Sharma. "Role of Liposome as Novel Carrier Molecule." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 3 (2023): 141–50. http://dx.doi.org/10.48165/ijppronline.2023.14312.

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Liposomes were discovered by Alec D Bangham in the year 1960.The term liposome means lipid body. They are categorized as a drug delivery system in which drug is targeted to a particular tissue. Liposomes can range from 25nm to 500nm in size. Usually, they have a sphere shape vesicles. They may be having one phospholipid bi- layer or more. They are widely used as drug targeting delivery system because they can penetrate tissues more precisely than free drugs and they have similarity between their lipid bilayer and cell membrane. They are also preferred more because of their drug entrapment effi

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Izumi, Kayano, Chihiro Saito, and Ryuji Kawano. "Liposome Deformation Induced by Membrane-Binding Peptides." Micromachines 14, no. 2 (2023): 373. http://dx.doi.org/10.3390/mi14020373.

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This paper presents an investigation of liposome deformation and shape distortion using four membrane-binding peptides: TAT and C105Y as cell-penetrating peptides (CPPs), and melittin and ovispirin as antimicrobial peptides (AMPs). Liposome deformation was monitored utilizing fluorescent microscopy, while the binding of peptides to the DOPC membrane was estimated through capacitance measurements. The degree of liposome deformation and shape distortion was found to be higher for the CPPs compared to the AMPs. Additionally, it was observed that C105Y did not induce liposome rupture, unlike the o

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Kim, Hyo-Tae, Jiseon Lee, Yeon-Ji Jo, and Mi-Jung Choi. "Application of Liposome Encapsulating Lactobacillus curvatus Extract in Cosmetic Emulsion Lotion." Materials 14, no. 24 (2021): 7571. http://dx.doi.org/10.3390/ma14247571.

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Probiotic extracts have various positive attributes, such as antioxidant, tyrosinase inhibitory, and antimicrobial activity. Lactobacillus curvatus produces bacteriocin, which activates the lipid membrane structure and has potential as a natural preservative for cosmetic emulsions. In this study, L. curvatus extract was encapsulated in liposomes and formulated as an oil-in-water (O/W) emulsion. Radical scavenging activity, tyrosinase inhibition, and challenge tests were conducted to confirm the liposome activity and the activity of the applied lotion emulsion. The liposome-encapsulated extract

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Harshesh, P. Vyas, R. Kumbhani Kerul, and H. Jagani Ravi. "ENHANCED ACTIVITY OF ANTIBIOTICS BY LIPOSOMAL DRUG DELIVERY." ENHANCED ACTIVITY OF ANTIBIOTICS BY LIPOSOMAL DRUG DELIVERY 1, no. 1 (2015): 01–11. https://doi.org/10.5281/zenodo.4047697.

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Liposome are the most widely used and the most extensively marketed nano-formulation that is being manufactured by pharmaceutical industries. Liposome can be modified in different size and structure. Conjugation of ligend with liposome surface increase the target specificity and changes the pharmacokinetic distribution of encapsulated drug. Different methods of preparation can produce different types of liposomes. Many marketed formulations are available as liposome and has proved to be more useful than the conventional formulations. Antibiotics of different classes such as quinolones, aminogl

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Suryawanshi, Yogita* Waghmare Vyankatesh Swami bhujayya durgadas Shaikh shirin fatema maulana Wangawar pallavi. "Preparation And Application of Liposome." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2615–24. https://doi.org/10.5281/zenodo.15091173.

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Made of the same substance as a cell membrane, a liposome is a tiny bubble, or vesicle. Drugs for cancer and other illnesses can be delivered using liposomes that have been loaded with medication. At the Babraham Institute in Cambridge, British haematologist Dr. Alec D. Bangham FRS initially described liposomes in 1961 (published 1964). They were found when Bangham and R. W. Horne added negative stain to dry phospholipids in order to test the institute's new electron microscope. The microscope images provided the first concrete proof that the cell membrane is a bilayer lipid structure, and the

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Gunda, Raghavendra Kumar, J. N. Suresh Kumar, G. Bhargavi, et al. "A Review on Formulation and Evaluation of Liposomal Drugs." British Journal of Multidisciplinary and Advanced Studies 4, no. 4 (2023): 31–44. http://dx.doi.org/10.37745/bjmas.2022.0268.

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A liposome is the drug delivery system used for the administration of various types of drugs or active substances essential for the treatment of various types of diseases. They play a major role in the target delivery of the drug to particular tissue without affecting the other body parts. Hence it is also called targeted drug delivery system. The term liposome means lipid body. It has been derived on the basis of name of subcellular particles, ribosome. Liposomes were first made by the British scientist Alec Bangham and colleagues at Babraham Cambridge in the mid- 1960s and they first publish

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Sangeeta, Sinku, Kumar Sharma Gaurav, and Singh Kushwaha |. Dr. Kaushal K. Chandrul Rahul. "Review on Assesment of Permeability of Enhancement Property of Hyaluronic Acid as Compare to Peg in Core Gel Liposome." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): International Journal of Trend in Scientific Research and Development. https://doi.org/10.31142/ijtsrd23313.

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New controlled transdermal drug delivery systems TDDS technologies electrically based, structure based and velocity based have been developed and commercialized for the transdermal delivery of troublesome drugs. The use of solvents that affect the skin barrier function is one of the classic strategies of penetration enhancement. The liposomes as a delivery system for hydrophobic and hydrophilic drugs is well recognized Standardized poly ethylene glycol modified PEGylated liposomes, which have been widely used in research as well as in pre clinical and clinical studies. The aim of present work

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Koehler, Jonas K., Lars Gedda, Leonie Wurster, et al. "Tailoring the Lamellarity of Liposomes Prepared by Dual Centrifugation." Pharmaceutics 15, no. 2 (2023): 706. http://dx.doi.org/10.3390/pharmaceutics15020706.

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Dual centrifugation (DC) is a new and versatile technique for the preparation of liposomes by in-vial homogenization of lipid-water mixtures. Size, size distribution, and entrapping efficiencies are strongly dependent on the lipid concentration during DC-homogenization. In this study, we investigated the detailed structure of DC-made liposomes. To do so, an assay to determine the ratio of inner to total membrane surfaces of liposomes (inaccessible surface) was developed based on either time-resolved or steady-state fluorescence spectroscopy. In addition, cryogenic electron microscopy (cryo-EM)

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Melnikova, E. V., D. V. Goryachev, A. A. Chaplenko, M. A. Vodyakova, A. R. Sayfutdinova, and V. A. Merkulov. "Development of liposomal drug formulations: quality attributes and methods for quality control." NANOMEDICINE, no. 6 (December 31, 2018): 33–39. http://dx.doi.org/10.24075/brsmu.2018.092.

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The use of nanostructured components in drug manufacturing and, more specifically, targeted drug delivery has recently become a major trend in the pharmaceutical industry. Nanodrugs encompass a wide range of pharmaceutical agents containing dendrimers, nanocrystals, micelles, liposomes, and polymer nanoparticles. Liposomes are the most well-studied nanoparticles and effective drug carriers. However, the more complex their structure is, the more process controls are needed and the more quality attributes have to be monitored, including the chemical properties of the liposomal fraction such as t

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Tanashyan, M. M., R. B. Medvedev, O. V. Lagoda, et al. "The state of cognitive functions after angioreconstructive operations on the carotid arteries." IMMUNO-ONCOLOGY, no. 5 (September 16, 2019): 65–71. http://dx.doi.org/10.24075/brsmu.2019.059.

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The use of nanostructured components in drug manufacturing and, more specifically, targeted drug delivery has recently become a major trend in the pharmaceutical industry. Nanodrugs encompass a wide range of pharmaceutical agents containing dendrimers, nanocrystals, micelles, liposomes, and polymer nanoparticles. Liposomes are the most well-studied nanoparticles and effective drug carriers. However, the more complex their structure is, the more process controls are needed and the more quality attributes have to be monitored, including the chemical properties of the liposomal fraction such as t

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Bartnikowska, Agnieszka, Barbara Pytel, and Dariusz Man. "The Impact of Propanol, N-Butanol and Pentanol on Aqueous Dispersions of Sonicated Liposomes. EPR Study." Ecological Chemistry and Engineering S 29, no. 4 (2022): 565–79. http://dx.doi.org/10.2478/eces-2022-0032.

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Abstract This paper presents the effect of selected alcohols on the fluidity of liposome membranes obtained in sonication of DPPC lecithin. Using the EPR technique, the duality of propanol, n-butanol and pentanol on the behaviour of the aqueous dispersion of liposomes was demonstrated. It was shown that after exceeding a certain concentration, these alcohols initiate dispersion foaming, leading to phase separation: liposome dispersion - lipid foam. The influence of the shape of the molecule and the length of hydrocarbon chains on the effectiveness of destabilisation of the structure of lipid m

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Zasadzinski, J. A., L. E. Scriven, and H. T. Davis. "Liposome structure and defects." Philosophical Magazine A 51, no. 2 (1985): 287–302. http://dx.doi.org/10.1080/01418610.1985.12069163.

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Aarti, Nimse* Dr. Sachin Kale Rutuja Giram Ashvini Kakad. "A Comprehensive Review on Liposomes: As A Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 3476–87. https://doi.org/10.5281/zenodo.14582120.

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This review explores the potential applications of liposomes as a drug delivery system, focusing on their structure, formulation methods, advantages, limitations, and recent breakthroughs. It also discusses the diverse range of drugs and therapeutic agents that can be encapsulated within liposomes and their clinical applications in targeting specific diseases. The review provides an in-depth analysis of liposome-based drug delivery.

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Attia, Mohamed Ahmed, Ebtessam Ahmed Essa, Toka Tarek Elebyary, Ahmed Mostafa Faheem, and Amal Ali Elkordy. "Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines." Pharmaceuticals 14, no. 11 (2021): 1173. http://dx.doi.org/10.3390/ph14111173.

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Vaccination is the most effective means of preventing infectious diseases and saving lives. Modern biotechnology largely enabled vaccine development. In the meantime, recent advances in pharmaceutical technology have resulted in the emergence of nanoparticles that are extensively investigated as promising miniaturized drug delivery systems. Scientists are particularly interested in liposomes as an important carrier for vaccine development. Wide acceptability of liposomes lies in their flexibility and versatility. Due to their unique vesicular structure with alternating aqueous and lipid compar

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Al-Amin, MD, Federica Bellato, Francesca Mastrotto, et al. "Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges." International Journal of Molecular Sciences 21, no. 5 (2020): 1611. http://dx.doi.org/10.3390/ijms21051611.

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Liposomes have been one of the most exploited drug delivery systems in recent decades. However, their large-scale production with low batch-to-batch differences is a challenge for industry, which ultimately delays the clinical translation of new products. We have investigated the effects of formulation parameters on the colloidal and biopharmaceutical properties of liposomes generated with a thin-film hydration approach and microfluidic procedure. Dexamethasone hemisuccinate was remotely loaded into liposomes using a calcium acetate gradient. The liposomes produced by microfluidic techniques s

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De Leo, Vincenzo, Francesco Milano, Angela Agostiano, and Lucia Catucci. "Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles." Polymers 13, no. 7 (2021): 1027. http://dx.doi.org/10.3390/polym13071027.

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Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility of liposomes has been exploited for the development of various carriers for the topical or systemic delivery of drugs and bioactive molecules, with the possibility of increasing their bioavailability and stability, and modulating and directing their release, while limiting the side effects at the same time. Nevertheless, first-generation vesicles suffer from some limitations including physical instability, short in vivo circulation lifetime, reduced payload, u

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Efimova, Аnna А., Svetlana A. Sorokina, Kseniya S. Trosheva, Alexander A. Yaroslavov, and Zinaida B. Shifrina. "Complexes of Cationic Pyridylphenylene Dendrimers with Anionic Liposomes: The Role of Dendrimer Composition in Membrane Structural Changes." International Journal of Molecular Sciences 24, no. 3 (2023): 2225. http://dx.doi.org/10.3390/ijms24032225.

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In the last decades, dendrimers have received attention in biomedicine that requires detailed study on the mechanism of their interaction with cell membranes. In this article, we report on the role of dendrimer structure in their interaction with liposomes. Here, the interactions between cationic pyridylphenylene dendrimers of the first, second, and third generations with mixed or completely charged pyridyl periphery (D16+, D215+, D229+, and D350+) with cholesterol-containing (CL/Chol/DOPC) anionic liposomes were investigated by microelectrophoresis, dynamic light scattering, fluorescence spec

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Gadekar, Utkarsha* Ulka Mote. "Liposome-Novel Drug Delivery Systems." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1146–52. https://doi.org/10.5281/zenodo.14211476.

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Because liposomes are highly biocompatible, biodegradable, and immunogenicity-free, they are now thought to be the most widely employed nanocarriers for a variety of hydrophobic and hydrophilic compounds that have the potential to be active. Moreover, liposomes have demonstrated improved drug solubility, regulated dispersion, and surface modification ability for focused, extended, and sustained release. Liposomes can be thought of as having developed from traditional, long-circulating, immune-system-targeting liposomes to actively targeted liposomes that respond to stimuli based on their compo

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Mulyadi, Nur Aini, Helmy Yusuf, and Noorma Rosita. "Solid State Characterization of Dried Liposomes in The Presence of Sucrose and HPMC as Dispersing Matrix." Bangladesh Pharmaceutical Journal 21, no. 1 (2018): 16–23. http://dx.doi.org/10.3329/bpj.v21i1.37901.

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Disaccharides, such as sucrose, have been reported to protect phospholipid membranes during drying, while HPMC is used as gel matrix to inhibit recrystallization. We have investigated the solid state characterization of dried liposome formulation (air-dried and freeze-dried) which was preserved in the presence of sucrose and dispersed in HPMC matrix. The dried liposomal featured cationic dimethyldioctadecylammonium (DDA) was produced to overcome detrimental phase separation in phospholipid membranes during manufacturing process. The effect of sucrose and HPMC on lipid phase behavior during deh

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Szebeni, Janos, Lajos Baranyi, Sandor Savay, et al. "Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction." American Journal of Physiology-Heart and Circulatory Physiology 279, no. 3 (2000): H1319—H1328. http://dx.doi.org/10.1152/ajpheart.2000.279.3.h1319.

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Intravenous injection of liposomes can cause significant pulmonary hypertension in pigs, a vasoconstrictive response that provides a sensitive model for the cardiopulmonary distress in humans caused by some liposomal drugs. The reaction was recently shown to be a manifestation of “complement activation-related pseudoallergy” (CARPA; Szebeni J, Fontana JL, Wassef NM, Mongan PD, Morse DS, Dobbins DE, Stahl GL, Bünger R, and Alving CR. Circulation 99: 2302–2309, 1999). In the present study we demonstrate that the composition, size, and administration method of liposomes have significant influence

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Ustinova, Tatiana M., Nikolai Vengerovich, and Mikhail A. Judin. "Experimental study of the liposomal form of fenoterol after improving the method of obtaining it." Pharmacy Formulas 2, no. 2 (2020): 30–37. http://dx.doi.org/10.17816/phf34272.

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The effect of different concentrations of cryoprotector (sucrose) on the efficiency of fenoterol inclusion in the lipid matrix during lyophilization has been studied. It has been shown that the liposomal form with the content of cryoprotector in the internal environment of liposomes 2.5 % and in the external environment equal to 2 % provides long-term preservation of the drug in the liposome cavity. Under these conditions, it is possible to achieve a monodisperse distribution of particles with an average diameter of 4.281.62 m. The assumed quantitative composition of the cryoprotector ensures

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M., Ravi* Dr. A. Srinu Naik B. Kasturi Bhai. "LIPOSOMAL GEL FOR TRANSDERMAL APPLICATION FOR THE TREATMENT OF TOPICAL INFECTIONS." Journal of Pharma Research 07, no. 12 (2018): 300–307. https://doi.org/10.5281/zenodo.7417371.

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<strong>Abstract</strong> <strong>Liposomes as artificial colloidal vesicular structure having hydrophilic core in a lipid bilayer membrane became one of the most tremendously explored drug delivery system. These spherical vesicles consist of amphiphilic molecule like cholesterol, sterols and can be used to deliver both hydrophilic drugs as well as lipophilic drug. These vesicles are differentiated on the basis of size, composition, method of preparation and application. Liposomes are biodegradable, non-immunogenic, biocompatible, provide targeted and prolonged release, change pharmacokinetic

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Zhang, Julia, Anna Froelich, and Bozena Michniak-Kohn. "Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches." Pharmaceutics 12, no. 3 (2020): 282. http://dx.doi.org/10.3390/pharmaceutics12030282.

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The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. For microemulsions, particle size, electrical conductivity and viscosity studies were performed to assess the structure of the investigated systems. An ex vivo skin permeation study has been conducted to compare these formulations. The dermal and transdermal delivery of meloxicam using these formul

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