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Journal articles on the topic 'Lipospheres'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Shubhra Rai, Gopal Rai, and Ashish Budhrani. "Development, Optimisation and Evaluation of Ketoprofen Lipospheres." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1853–63. http://dx.doi.org/10.26452/ijrps.v11ispl4.4389.

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Lipospheres represent a novel type of fat-based encapsulation system produced for the topical drug delivery of bioactive compounds. The goal of this research work was to develop lipospheres, including ketoprofen applied for topical skin drug delivery. Ketoprofen lipospheres were formulated by melt emulsification method using stearic acid and Phospholipon® 90G. The lipospheres were analysed in terms of particle size and morphology, entrapment efficiency, Differential scanning calorimetry, In-vitro drug release, In-vivo (Anti-inflammatory activity). Outcomes of research revealed that particle si

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Saini, Sarika, and Aman Mittal. "Formulation and in-vitro evaluation of Glipizide (Anti diabetic drug) Liposphere." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 116–19. http://dx.doi.org/10.22270/jddt.v8i6-s.2096.

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Objective- The aim of the present study was to formulate and in- vitro study of glipizide liposphere by using melt dispersion technique. Methods- Glipizide Liposphere system composed of paraffin wax, Stearic acid as lipid phase and sodium lauryl sulphate as surfactant. Glipizide lipospheres were prepared by using melt dispersion technique. Formulation of Glipizide was evaluated such as organoleptic properties, particle size, drug content, entrapment efficiency in-vitro study and stability of the lipospheres. Result- The formation of glipizide lipospheres by using melt dispersion te

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3

Tanwar, Rajni, Arshdeep Singh Brar, and Puja Gulati. "Norfloxacin-Loaded Lipospheres: A Novel Lipid-Based Approach for Enhanced Solubility, Stability and Bioavailability." Journal of Neonatal Surgery 14, no. 7S (2025): 618–32. https://doi.org/10.52783/jns.v14.2462.

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Norfloxacin, a second-generation fluoroquinolone exhibits potent antibacterial activity but suffers from poor oral bioavailability due to limited solubility, permeability and extensive first-pass metabolism. Liposphere-based drug delivery systems offer a promising approach to overcoming these limitations by encapsulating norfloxacin in lipid matrices enhancing its solubility, stability and controlled release. This review explores the formulation strategies, characterization and evaluation of norfloxacin-loaded lipospheres. Various preparation techniques including solvent evaporation, melt disp

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4

Momoh, MA, FC Kenechukwu, MS Gwarzo, and PF Builders. "Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery." Dhaka University Journal of Pharmaceutical Sciences 14, no. 1 (2015): 17–27. http://dx.doi.org/10.3329/dujps.v14i1.23730.

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Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for in vitro and in vivo performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and in vitro drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%

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Kajal, Bilgaiyan* Kaushelendra Mishra Kajal Sharma Parul Mehta. "Development And Characterization Of Liposphere Of Antidiabetic Drug Nateglinide For Enhance Bioavailability." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 177–86. https://doi.org/10.5281/zenodo.12617074.

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The aim of this study was to develop and characterize lipospheres of the antidiabetic drug. Nateglinide to enhance its bioavailability. Nateglinide, a poorly water-soluble drug, poses challenges in achieving optimal therapeutic effects due to its limited solubility and bioavailability. Lipospheres, lipid-based drug delivery systems, offer a promising approach to overcome these challenges by enhancing drug solubility and bioavailability. In this research, lipospheres of Nateglinide were prepared using a solvent evaporation method with various lipids and surfactants. The formulated lipospheres w

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6

Neeraj, Kumar Rathour* Ajay Singh Saurabh Mishra. "A Review on Orally Administration of Lipospheres for Enhancement of Solubility." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1634–52. https://doi.org/10.5281/zenodo.15044972.

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Lipospheres are lipid-based drug delivery systems designed to enhance the solubility and bioavailability of poorly water-soluble drugs. These colloidal carriers consist of a solid hydrophobic lipid core stabilized by a phospholipid layer, offering advantages such as high drug entrapment, controlled release, and improved drug stability. Lipospheres are particularly beneficial for the oral administration of Biopharmaceutics Classification System (BCS) Class II drugs, including cyclosporine A, by improving their dissolution rate and gastrointestinal absorption. Various preparation techniques, inc

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7

Zaki, Randa Mohammed, Mohammed F. Aldawsari, Manal A. Alossaimi, et al. "Brain Targeting of Quetiapine Fumarate via Intranasal Delivery of Loaded Lipospheres: Fabrication, In-Vitro Evaluation, Optimization, and In-Vivo Assessment." Pharmaceuticals 15, no. 9 (2022): 1083. http://dx.doi.org/10.3390/ph15091083.

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A liposphere system for intranasal delivery of quetiapine fumarate (QTF) was created to assess the potential for enhanced drug delivery. We investigated the effects of particle size, entrapment effectiveness, poly dispersibility index, and pluronic incorporation percentage on these variables. The optimal formula was examined using a TEM, and investigations into DSC, XRD, and FTIR were made. Optimized liposphere formulation in vitro dissolution investigation with a mean diameter of 294.4 ± 18.2 nm revealed about 80% drug release in 6 h. The intranasal injection of QTF-loaded lipospheres showed

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8

Nnamani, Petra Obioma, Edith Obioma Diovu, Ikechukwu Emmanuel Peter, et al. "Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract." Processes 11, no. 9 (2023): 2557. http://dx.doi.org/10.3390/pr11092557.

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Purpose: Inflammation of various degrees is common among humans. There are associated side effects with orthodox delivery systems and anti-inflammatory agents; hence, the study investigated the characteristics of herbal lipospheres and the anti-inflammatory potency of the lipospheres formulated from Pentaclethra macrophylla with the view to having a drug with a better delivery system and lesser side effects. Methods: Herbal lipospheres were formulated using solidified reverse micellar solutions (SRMS) of P90H and goat fat and characterized for particle size and morphology, pH time dependent an

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9

Kumar, Anil, Umesh K. Jain, and Ajay Patel. "Formulation Development and Evaluation of Liposphere of Poor Water Soluble Drug for Hyperlipidemia." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 23–30. http://dx.doi.org/10.22270/jddt.v11i2.4578.

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Lipospheres offer a new approach to improve an aqueous solubility of BCS class-II drugs. Simvastatin is a third generation fibric acid derivative belonging to this class, employed clinically as a hypolipidemic agent to lessen the risk caused by atherosclerosis. An attempt was made to improve aqueous solubility of Simvastatin by aid of stearic acid and Paraffin oil. The factorial batches of the Simvastatin lipospheres were formulated by melt dispersion technique using 32 factorial design with variables X1- concentration of stearic acid and X2- concentration of paraffin oil and responses Y1 - %

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10

Elgart, Anna, Irina Cherniakov, Yanir Aldouby, Abraham J. Domb, and Amnon Hoffman. "Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds." Chemistry and Physics of Lipids 165, no. 4 (2012): 438–53. http://dx.doi.org/10.1016/j.chemphyslip.2012.01.007.

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11

UNGER, EVAN C., THOMAS P. McCREERY, ROBERT H. SWEITZER, VERONICA E. CALDWELL, and YUNQIU WU. "Acoustically Active Lipospheres Containing Paclitaxel." Investigative Radiology 33, no. 12 (1998): 886–92. http://dx.doi.org/10.1097/00004424-199812000-00007.

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12

Novakovic, Valerie A., James D. Baleja, and Gary E. Gilbert. "The Factor VIIII C2 Domain Shows Stereospecificity for Phosphatidyl-L-Serine and Increases Factor IXa Activity." Blood 112, no. 11 (2008): 3090. http://dx.doi.org/10.1182/blood.v112.11.3090.3090.

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Abstract Background: Factor VIII is an essential cofactor in the blood coagulation cascade and shows greatly increased activity when bound to phospholipid membranes. While high proportions of various negatively-charged phospholipids support binding of factor VIII, only phosphatidyl-L-serine (Ptd-L-Ser) supports stereospecific affinity when present at physiologically relevant proportions. Factor VIII binds to phospholipid membranes primarily through its C2 domain, but binding is also mediated by the C1 domain (Meems et al., abstract ASH 2008). However, the membrane-binding properties of the iso

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13

Cavalli, Roberta, Otto Caputo, and Maria Rosa Gasco. "Solid lipospheres of doxorubicin and idarubicin." International Journal of Pharmaceutics 89, no. 1 (1993): R9—R12. http://dx.doi.org/10.1016/0378-5173(93)90313-5.

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14

Bekerman, Tania, Jacob Golenser, and Abraham Domb. "Cyclosporin Nanoparticulate Lipospheres for Oral Administration." Journal of Pharmaceutical Sciences 93, no. 5 (2004): 1264–70. http://dx.doi.org/10.1002/jps.20057.

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15

Toongsuwan, Siriporn, Luk-Chiu Li, Bryan K. Erickson, and Hung-Chih Chang. "Formulation and characterization of bupivacaine lipospheres." International Journal of Pharmaceutics 280, no. 1-2 (2004): 57–65. http://dx.doi.org/10.1016/j.ijpharm.2004.04.020.

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16

Galkin, Mikhail, Harlan Bradford, and Sriram Krishnaswamy. "Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?" Blood 126, no. 23 (2015): 2267. http://dx.doi.org/10.1182/blood.v126.23.2267.2267.

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Abstract Membrane binding by factors Xa and Va plays an essential role in facilitating their interaction to yield membrane-bound prothrombinase. This concept is backed by a large body of biochemical work using synthetic phospholipid vesicles typically composed of 25% phosphatidylserine (PS) and 75% phosphatidylcholine (PC). However, it remains uncertain whether kinetic and thermodynamic findings with these membranes can be extrapolated to explain the assembly of prothrombinase on cell surfaces relevant to coagulation in the vasculature. We examined the binding of fluorescent derivatives of Xa

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17

Barakat, Nahla S., and Alaa Eldeen B. Yassin. "In Vitro Characterization of Carbamazepine-Loaded Precifac Lipospheres." Drug Delivery 13, no. 2 (2006): 95–104. http://dx.doi.org/10.1080/10717540500313661.

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18

Cortesi, R. "Production of lipospheres as carriers for bioactive compounds." Biomaterials 23, no. 11 (2002): 2283–94. http://dx.doi.org/10.1016/s0142-9612(01)00362-3.

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19

Tursilli, Rosanna, Alberto Casolari, Valentina Iannuccelli, and Santo Scalia. "Enhancement of melatonin photostability by encapsulation in lipospheres." Journal of Pharmaceutical and Biomedical Analysis 40, no. 4 (2006): 910–14. http://dx.doi.org/10.1016/j.jpba.2005.08.025.

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20

Morel, Silvia, Maria Rosa Gasco, and Roberta Cavalli. "Incorporation in lipospheres of [d-Trp-6]LHRH." International Journal of Pharmaceutics 105, no. 2 (1994): R1—R3. http://dx.doi.org/10.1016/0378-5173(94)90466-9.

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21

Amselem, Shimon, Carl R. Alving, and Abraham J. Domb. "Polymeric biodegradable lipospheres™ as vaccine delivery systems." Polymers for Advanced Technologies 3, no. 6 (1992): 351–57. http://dx.doi.org/10.1002/pat.1992.220030611.

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22

Pandit, Sachin S., and Arun T. Patil. "Formulation andin vitroevaluation of buoyant controlled release lercanidipine lipospheres." Journal of Microencapsulation 26, no. 7 (2009): 635–41. http://dx.doi.org/10.3109/02652040802593908.

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23

Natarajan, Satheesh, and Prabakaran Laksmanan. "Formulation of Ofloxacin Loaded Lipospheres with Improved Oral Bioavailability." Pharmaceutical Nanotechnology 1, no. 4 (2013): 306–15. http://dx.doi.org/10.2174/221173850104131209164546.

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24

Maheen, Safirah, and Akhtar Rasul. "Formulation, characterization and statistical optimization of enalapril-loaded lipospheres." Bioinspired, Biomimetic and Nanobiomaterials 9, no. 4 (2020): 202–12. http://dx.doi.org/10.1680/jbibn.19.00065.

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25

Yalavarthi, PrasannaRaju, ThusharaBindu Dudala, NagaLakshmi Mudumala, et al. "A perspective overview on lipospheres as lipid carrier systems." International Journal of Pharmaceutical Investigation 4, no. 4 (2014): 149. http://dx.doi.org/10.4103/2230-973x.143112.

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26

Motawee, Abeer, Elsayed Khafagy, Ahmed Gardouh, and Mamdouh Ghourab. "Lipospheres and Pro-Nanolipospheres: Advancements in Drug Delivery Systems." Records of Pharmaceutical and Biomedical Sciences 7, no. 3 (2023): 41–50. http://dx.doi.org/10.21608/rpbs.2023.190694.1209.

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27

Bloem, Esther, Henriet Meems, Maartje van den Biggelaar, Koen Mertens, and Alexander B. Meijer. "Factor VIII Region 1811–1818 Is Involved in Factor IXa Binding and Factor VIIIa Stability." Blood 120, no. 21 (2012): 3357. http://dx.doi.org/10.1182/blood.v120.21.3357.3357.

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Abstract Abstract 3357 Previously, we identified a role for the lysine residue couple 1967/1968 in the stability of activated factor VIII (FVIIIa). Using tandem mass tags (TMT 126/127) in combination with mass spectrometry, we identified lysine residues involved in the interaction between the A2 domain and the rest of heterodimer (A1/A3-C1-C2) of FVIIIa (Bloem et al., J Biol Chem 2012;287:5575–83). Upon FVIII activation and A2 domain dissociation, the highest increase in surface exposure occurred for the lysine couple 1967/1968, and functional studies confirmed the role thereof in FVIIIa stabi

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28

Hanif, Muhammad, Hafeez U. Khan, Samina Afzal, et al. "Formulation, characterization and optimization of nebivolol-loaded sustained release lipospheres." Tropical Journal of Pharmaceutical Research 18, no. 2 (2019): 223. http://dx.doi.org/10.4314/tjpr.v18i2.2.

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29

Hanif, Muhammad, Hafeez Ullah Khan, Safirah Maheen, et al. "Formulation, characterization, and pharmacokinetic evaluation of Ivabradine-Nebivolol co-encapsulated lipospheres." Journal of Molecular Liquids 344 (December 2021): 117704. http://dx.doi.org/10.1016/j.molliq.2021.117704.

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30

Yehia, Soad A., Ahmed H. Elshafeey, and Ibrahim Elsayed. "Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation." Journal of Pharmacy and Pharmacology 64, no. 10 (2012): 1425–37. http://dx.doi.org/10.1111/j.2042-7158.2012.01530.x.

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31

del Pino, Pablo, Almudena Munoz-Javier, Dialechti Vlaskou, Pilar Rivera Gil, Christian Plank, and Wolfgang J. Parak. "Gene Silencing Mediated by Magnetic Lipospheres Tagged with Small Interfering RNA." Nano Letters 10, no. 10 (2010): 3914–21. http://dx.doi.org/10.1021/nl102485v.

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32

MORAIS, HARRIMAN ALEY, CRISTIANE MÁRCIA DA SILVA BARBOSA, FERNANDA MENEGHELLO DELVIVO, HERMAN SANDER MANSUR, MÔNICA CRISTINA DE OLIVEIRA, and MARIALICE PINTO COELHO SILVESTRE. "COMPARATIVE STUDY OF MICROENCAPSULATION OF CASEIN HYDROLYSATES IN LIPOSPHERES AND LIPOSOMES." Journal of Food Biochemistry 28, no. 1 (2004): 21–41. http://dx.doi.org/10.1111/j.1745-4514.2004.tb00053.x.

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33

Barbosa, Cristiane MS, Harriman A. Morais, Fernanda M. Delvivo, Herman S. Mansur, Mônica C. De Oliveira, and Marialice PC Silvestre. "Papain hydrolysates of casein: molecular weight profile and encapsulation in lipospheres." Journal of the Science of Food and Agriculture 84, no. 14 (2004): 1891–900. http://dx.doi.org/10.1002/jsfa.1855.

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34

Vlaskou, Dialechti, Olga Mykhaylyk, Florian Krötz, et al. "Magnetic and Acoustically Active Lipospheres for Magnetically Targeted Nucleic Acid Delivery." Advanced Functional Materials 20, no. 22 (2010): 3881–94. http://dx.doi.org/10.1002/adfm.200902388.

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35

Chime, SalomeA, EC Umeyor, VI Onyishi, GC Onunkwo, and AA Attama. "Analgesic and micromeritic evaluations of SRMS-based oral lipospheres of diclofenac potassium." Indian Journal of Pharmaceutical Sciences 75, no. 3 (2013): 302. http://dx.doi.org/10.4103/0250-474x.117436.

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36

Rawat Sing, Manju, Deependra Singh, and Swarnlata Saraf. "Influence of Selected Formulation Variables on the Preparation of Peptide Loaded Lipospheres." Trends in Medical Research 6, no. 2 (2011): 101–15. http://dx.doi.org/10.3923/tmr.2011.101.115.

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37

Bhatia, Amit, Bhupinder Singh, Veena Rani, and O. P. Katare. "Formulation, Characterization, and Evaluation of Benzocaine Phospholipid-Tagged Lipospheres for Topical Application." Journal of Biomedical Nanotechnology 3, no. 1 (2007): 81–89. http://dx.doi.org/10.1166/jbn.2007.009.

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38

Iannuccelli, V., G. Coppi, S. Sergi, M. Mezzena, and S. Scalia. "In vivo and in vitro Skin Permeation of Butyl Methoxydibenzoylmethane from Lipospheres." Skin Pharmacology and Physiology 21, no. 1 (2008): 30–38. http://dx.doi.org/10.1159/000109656.

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39

Shortencarier, M. J., P. A. Dayton, S. H. Bloch, P. A. Schumann, T. O. Matsunaga, and K. W. Ferrara. "A method for radiation-force localized drug delivery using gas-filled lipospheres." IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 51, no. 7 (2004): 822–31. http://dx.doi.org/10.1109/tuffc.2004.1320741.

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40

Singh, Charan, L. V. Seshu Kumar Koduri, Arti Singh, and Sarasija Suresh. "Novel potential for optimization of antitubercular therapy: Pulmonary delivery of rifampicin lipospheres." Asian Journal of Pharmaceutical Sciences 10, no. 6 (2015): 549–62. http://dx.doi.org/10.1016/j.ajps.2015.08.003.

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41

Shortencarier, Michaelann, Susannah Bloch, Paul Dayton, et al. "A new targeted drug delivery method using ultrasound and acoustically active lipospheres." Journal of the Acoustical Society of America 117, no. 4 (2005): 2473. http://dx.doi.org/10.1121/1.4787513.

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42

Lu, Ke, Hong-Zheng Wang, Yi-Jun Gao, and Jing Zhu. "Development and Evaluation of Aceclofenac Loaded Lipospheres for the Treatment of Osteoarthritis." Journal of Biomaterials and Tissue Engineering 5, no. 6 (2015): 504–8. http://dx.doi.org/10.1166/jbt.2015.1335.

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43

Hettiarachchi, Kanaka, Shirley Zhang, Steven Feingold, Abraham P. Lee, and Paul A. Dayton. "Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy." Biotechnology Progress 25, no. 4 (2009): 938–45. http://dx.doi.org/10.1002/btpr.214.

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44

Attama, A. A., and V. E. Mpamaugo. "Pharmacodynamics of Piroxicam from Self-Emulsifying Lipospheres Formulated with Homolipids Extracted fromCapra hircus." Drug Delivery 13, no. 2 (2006): 133–37. http://dx.doi.org/10.1080/10717540500313430.

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45

Kommineni, Nagavendra, Raju Saka, Upendra Bulbake, and Wahid Khan. "Cabazitaxel and thymoquinone co-loaded lipospheres as a synergistic combination for breast cancer." Chemistry and Physics of Lipids 224 (November 2019): 104707. http://dx.doi.org/10.1016/j.chemphyslip.2018.11.009.

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46

SCALIA, S., R. TURSILLI, N. SALA та V. IANNUCCELLI. "Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-β-cyclodextrin". International Journal of Pharmaceutics 320, № 1-2 (2006): 79–85. http://dx.doi.org/10.1016/j.ijpharm.2006.04.008.

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47

Cavalli, R., S. Morel, M. R. Gasco, P. Chetoni, and m. F. Saettone. "Preparation and evaluation in vitro of colloidal lipospheres containing pilocarpine as ion pair." International Journal of Pharmaceutics 117, no. 2 (1995): 243–46. http://dx.doi.org/10.1016/0378-5173(94)00339-7.

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48

Tosi, A., S. Mazzitelli, N. Bozzuto, B. Bertini, G. Luca, and C. Nastruzzi. "Tripalmitin-based cationic lipospheres: Preparation, characterization and in Lab-on-a-chip applications." Journal of Controlled Release 116, no. 2 (2006): e58-e60. http://dx.doi.org/10.1016/j.jconrel.2006.09.049.

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49

Singh, Charan, L. V. Seshu Kumar Koduri, Vaibhav Dhawale, et al. "Potential of aerosolized rifampicin lipospheres for modulation of pulmonary pharmacokinetics and bio-distribution." International Journal of Pharmaceutics 495, no. 2 (2015): 627–32. http://dx.doi.org/10.1016/j.ijpharm.2015.09.036.

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50

Kumar, S. Pradeep, and Prathibha D. "Current Approaches and Pharmaceutical Applications of Colloidosome Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1832–40. http://dx.doi.org/10.37285/ijpsn.2012.5.4.2.

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Recently a number of lipid based systems like lipospheres, liposomes, niosomes, ethosomes, and transferosomes have been developed. The purpose of this review article on colloidosome drug delivery was to compile the focus on the types, properties, fabrication techniques, characterization and stability of colloidosomes. This system also solves the problem of insolubility, instability, rapid degradation and is widely used in specialized areas like protein delivery, gene delivery, targeting to the brain and tumor targeting. In a series of vascular systems, colloidosome represents an advanced tool

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