Academic literature on the topic 'Liquid and gas chromatography coupled with tandem mass spectrometry and high resolution mass spectrometry (UHPLC/GC - MS/MS and UHPLC-HRMS)'

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Journal articles on the topic "Liquid and gas chromatography coupled with tandem mass spectrometry and high resolution mass spectrometry (UHPLC/GC - MS/MS and UHPLC-HRMS)"

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Syahfitr, Sari Anggraini, and Dan Ridho Asra. "Analysis of Medicinal Chemicals Contained on Jamu: A Review." Asian Journal of Pharmaceutical Research and Development 9, no. 2 (2021): 33–46. http://dx.doi.org/10.22270/ajprd.v9i2.931.

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Background: Jamu is commonly known as an Indonesian traditional herbal medicine that contains ingredients or ingredients derived from plants, animals, minerals, galenic, or mixtures of these ingredients that have been hereditary for medicinal use. Some studies reported the presence of medicinal chemicals that are deliberately added to Jamu. Jamuthat containing medicinal chemicals usually had a faster healing effect compared to Jamu that do not contain medicinal chemicals. Jamu added medicinal chemicals cause serious side effects if it is consumed regularly, overdose, and long period consumptio
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Szulc, Justyna, Małgorzata Okrasa, Katarzyna Majchrzycka, et al. "Microbiological and Toxicological Hazards in Sewage Treatment Plant Bioaerosol and Dust." Toxins 13, no. 10 (2021): 691. http://dx.doi.org/10.3390/toxins13100691.

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Despite the awareness that work in the sewage treatment plant is associated with biological hazards, they have not been fully recognised so far. The research aims to comprehensively evaluate microbiological and toxicological hazards in the air and settled dust in workstations in a sewage treatment plant. The number of microorganisms in the air and settled dust was determined using the culture method and the diversity was evaluated using high-throughput sequencing. Endotoxin concentration was assessed with GC-MS (gas chromatography-mass spectrometry) while secondary metabolites with LC-MS/MS (l
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Dahibhate, Nilesh Lakshman, and Kundan Kumar. "Metabolite profiling of Bruguiera cylindrica reveals presence of potential bioactive compounds." PeerJ Analytical Chemistry 4 (May 4, 2022): e16. http://dx.doi.org/10.7717/peerj-achem.16.

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Bruguiera cylindrica parts are commonly used in Chinese and Indian traditional medicine to treat diarrhea, fever, and many ailments. The present study aims non targeted analysis of key secondary metabolites of B. cylindrica by gas chromatography mass spectrometry (GC-MS) and ultra-high performance liquid chromatography hybrid quadrupole-Exactive-Orbitrap high resolution mass spectrometry (UHPLC-Q-Exactive Orbitrap HRMS). GC-MS and UHPLC-Q-Exactive Orbitrap HRMS were utilized for metabolic profiling of ethyl acetate extract of B. cylindrica leaves. Key metabolites in the extract were identified
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La Maida, Nunzia, Manuela Pellegrini, Esther Papaseit, et al. "Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS." International Journal of Molecular Sciences 21, no. 24 (2020): 9414. http://dx.doi.org/10.3390/ijms21249414.

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The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot study has been carried out using a combination of an initial last generation gas chromatography-mass spectrometry (GC-MS) screening method for the determination of JWH-122, JWH-210, UR-144) in oral fluid (OF) of consumers and an ultra-high performance liquid chromatography high resolution mass spectrometry (UHPLC-HRMS) confirmatory method for the quantification of the pare
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Rubić, Ivana, Richard Burchmore, Stefan Weidt, et al. "Multi Platforms Strategies and Metabolomics Approaches for the Investigation of Comprehensive Metabolite Profile in Dogs with Babesia canis Infection." International Journal of Molecular Sciences 23, no. 3 (2022): 1575. http://dx.doi.org/10.3390/ijms23031575.

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Canine babesiosis is an important tick-borne disease worldwide, caused by parasites of the Babesia genus. Although the disease process primarily affects erythrocytes, it may also have multisystemic consequences. The goal of this study was to explore and characterize the serum metabolome, by identifying potential metabolites and metabolic pathways in dogs naturally infected with Babesia canis using liquid and gas chromatography coupled to mass spectrometry. The study included 12 dogs naturally infected with B. canis and 12 healthy dogs. By combining three different analytical platforms using un
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Marchei, Emilia, Maria Alias Ferri, Marta Torrens, et al. "Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers." International Journal of Molecular Sciences 22, no. 8 (2021): 4000. http://dx.doi.org/10.3390/ijms22084000.

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The use of the new psychoactive substances is continuously growing and the implementation of accurate and sensible analysis in biological matrices of users is relevant and fundamental for clinical and forensic purposes. Two different analytical technologies, high-sensitivity gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) were used for a screening analysis of classic drugs and new psychoactive substances and their metabolites in urine of formed heroin addicts under methadone maintenance therapy. Sample
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Scendoni, Roberto, Emanuele Bury, Erika Buratti, et al. "Detection of Morphine and Opioids in Fingernails: Immunohistochemical Analysis and Confirmation with Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry." Toxics 10, no. 8 (2022): 420. http://dx.doi.org/10.3390/toxics10080420.

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This study aimed to investigate the detection of morphine in fingernails from forensic autopsies using immunohistochemistry (IHC), with confirmation by ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS). A primary antibody specific to morphine and a secondary antibody conjugated to horseradish peroxidase (HRP) was used. IHC on specimens of Subjects A and B (both drug addicts) resulted in the detection of morphine on a cell layer of the nail plate matrix. UHPLC-HRMS and GC-MS analysis showed that Subject A had a morphine concentration of 0.3
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Meirelles, João Victor, Débora Cristina Diniz Estevam, Vanessa Farelo dos Santos, et al. "Optimized Extraction Method for Neutral Cannabinoids Quantification Using UHPLC-HRMS/MS." Biomolecules 15, no. 2 (2025): 246. https://doi.org/10.3390/biom15020246.

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The Cannabis market is experiencing steady global growth. Cannabis herbal extracts (CHE) are interesting and sought-after products for many clinical conditions. The medical potential of these formulations is mainly attributed to neutral cannabinoids, such as cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabinol (CBN), and their non-standardized content poses a significant fragility in these pharmaceutical inputs. High-resolution mass spectrometry portrays a powerful alternative to their accurate monitoring; however, further analytical steps need to be critically optimized to keep up wi
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Pellegrini, Manuela, Emilia Marchei, Esther Papaseit, Magí Farré, and Simona Zaami. "UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers." Medicina 56, no. 8 (2020): 408. http://dx.doi.org/10.3390/medicina56080408.

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Background and Objectives: The use of synthetic cannabinoids has increased around the world. As a result, the implementation of accurate analysis in human biological matrices is relevant and fundamental. Two different analytical technologies, ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) and high-sensitivity gas chromatography-mass spectrometry (GC-MS) were used for the determination of three synthetic cannabinoids JWH-122, JWH 210, UR-144 and their metabolites in urine of consumers. Materials and Methods: Sample preparation included an initial hyd
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Pezzatti, Julian, Víctor González-Ruiz, Julien Boccard, Davy Guillarme, and Serge Rudaz. "Evaluation of Different Tandem MS Acquisition Modes to Support Metabolite Annotation in Human Plasma Using Ultra High-Performance Liquid Chromatography High-Resolution Mass Spectrometry for Untargeted Metabolomics." Metabolites 10, no. 11 (2020): 464. http://dx.doi.org/10.3390/metabo10110464.

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Ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is a powerful and essential technique for metabolite annotation in untargeted metabolomic applications. The aim of this study was to evaluate the performance of diverse tandem MS (MS/MS) acquisition modes, i.e., all ion fragmentation (AIF) and data-dependent analysis (DDA), with and without ion mobility spectrometry (IM), to annotate metabolites in human plasma. The influence of the LC separation was also evaluated by comparing the performance of MS/MS acquisition in combination with three co
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Dissertations / Theses on the topic "Liquid and gas chromatography coupled with tandem mass spectrometry and high resolution mass spectrometry (UHPLC/GC - MS/MS and UHPLC-HRMS)"

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Arbouche, Nadia. "Aspects analytiques, cliniques et médico-judiciaires liés à l’identification de molécules à pouvoir hypoglycémiant dans les intoxications par antidiabétiques." Electronic Thesis or Diss., Strasbourg, 2022. http://www.theses.fr/2022STRAJ020.

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L'utilisation des médicaments antidiabétiques, malgré leurs fins thérapeutiques, n'est pas dénuée de risques. Le plus grand risque lié à l'utilisation de ces médicaments est l'hypoglycémie, qui peut être fatale en cas d'utilisation inappropriée. L'utilisation détournée est en fait assez bien connue à des fins criminelles de suicide et de meurtre, comme substances dopantes dans le milieu sportif (dans le cas de l'insuline) et dans le cadre des hypoglycémies factices (syndrome de Münchhausen). Dans le cadre de ma thèse, je me suis intéressé à 5 familles d'antidiabétiques oraux (sulfamides hypogl
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Conference papers on the topic "Liquid and gas chromatography coupled with tandem mass spectrometry and high resolution mass spectrometry (UHPLC/GC - MS/MS and UHPLC-HRMS)"

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Hajslova, Jana, Enrico Valli, Klara Navratilova, and Tullia Gallina Toschi. "Metabolic fingerprinting strategies for authentication challenge: EVOO adulterated by soft deodorized olive oil." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/qepz3229.

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Extra virgin olive oil (EVOO) is a high value commodity that might be subject of various fraudulent practices. One of them, addition of lower grade, soft-deodorized olive oil to EVOO has recently become of concern, as such adulterant detection is not an easy task. In this study, aqueous methanolic extracts of a unique set of authentic EVOOs, soft-deodorized oils and their admixtures obtained within the OLEUM EU project (http://www.oleumproject.eu/) were investigated. Using ultra-high performance liquid chromatography coupled to hybrid quadrupole time-of-flight high-resolution tandem mass spect
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