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Dissertations / Theses on the topic 'Liquid Chromatography Mass Spectrometry Analysis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Martin, Nicholas Joseph. "Surface analysis for proteomics via liquid extraction surface analysis mass spectrometry and liquid chromatography mass spectrometry." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6493/.

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Liquid extraction surface analysis (LESA) is an ambient ionisation technique which allows direct analysis of surfaces coupled with mass spectrometry. LESA mass spectrometry has been used successfully to analyse small molecules, but there are a limited number of examples where the approach has been applied to protein analysis. The work presented here aims to develop novel applications of LESA mass spectrometry of proteins. LESA mass spectrometry was used to analyse intact proteins from polymeric membranes. The rationale for these experiments was the potential application to analyse proteins ele

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2

Dolci, Monica. "Liquid chromatography-mass spectrometry analysis of oligolactic acids." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/35549.

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The project has demonstrated the application of liquid chromatography coupled to mass spectrometry (LC-MS) for the characterisation of oligolactic acids (OLAs), employed as pharmaceutical excipients in metered dose inhalers. OLAs proved to be difficult to characterise because of their complexity, which was ascribed. to the presence of repeated structural monomeric units and a nonrepeating moiety (the head group). Furthermore, during the course of method development the potential presence of degradation products and impurities had to be considered for quality control purposes. Various LC-MS met

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3

Sun, Xiaobo. "Forensic Applications of Gas Chromatography/Mass Spectrometry, High Performance Liquid Chromatography--Mass Spectrometry and Desorption Electrospray Ionization Mass Spectrometry with Chemometric Analysis." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1329517616.

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4

Crnogorac, Goranka. "Analysis of dithiocarbamate fungicide residues by liquid chromatography, mass spectrometry and isotope ratio mass spectrometry." Aachen Shaker, 2008. http://d-nb.info/993691447/04.

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5

Karu, Kersti. "Analysis of Oxysterols by capillary Liquid Chromatography Tandem Mass Spectrometry." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509399.

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6

Keski-Hynnilä, Helena. "Liquid chromatography - and capillary electrophoresis - mass spectrometry in glucuronide analysis." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/keski-hynnila/.

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7

Nicolaou, Anna, Mojgan Masoodi, and Adnan A. Mir. "Lipidomic analysis of prostanoids by liquid chromatography-electrospray tandem mass spectrometry." Springer, 2009. http://hdl.handle.net/10454/4575.

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no<br>Lipidomics aim to generate qualitative and quantitative information on different classes of lipids and their species, and when applied in conjunction with proteomic and genomic assays, facilitate the comprehensive study of lipid metabolism in cellular, organ or body systems. Advances in mass spectrometry have underpinned the expansion of lipidomic methodologies. Prostanoids are potent autacoids present in a plethora of cellular systems, known best for their intimate role in inflammation. Electrospray ionisation (ESI) allows the efficient ionisation of prostanoids in aqueous systems. ESI

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8

Crnogorac, Goranka [Verfasser]. "Analysis of Dithiocarbamate Fungicide Residues by Liquid Chromatography/Mass Spectrometry and Isotope Ratio Mass Spectrometry / Goranka Crnogorac." Aachen : Shaker, 2009. http://d-nb.info/1156517389/34.

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9

Scullion, Simon Daniel. "The analysis of surfactants and their determination in surface water by liquid chromatography and liquid chromatography-mass spectrometry." Thesis, Sheffield Hallam University, 1997. http://shura.shu.ac.uk/20338/.

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Linear alkylbenzene sulphonates (LAS) and alkylphenol polyethoxylates (APEO), the surfactants most used in this country, are complex mixtures of oligomers and homologues. Due to their excellent surface active properties they are widely used as ingredients in many detergent formulations both in the home and more importantly in industry. For several years research has been carried out in order to understand the environmental impact of these widely used groups of compounds. However, some of the analytical techniques developed are not able to give reliable information concerning individual oligome

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10

Rohlfs, Rebecca L. "Mass Spectrometry Analysis of Methylated Ribosomal RNA." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024445.

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11

ANTONOVICH, ROBERT STEVEN. "APPLICABILITY OF MASS SPECTROMETRY TO DETECT COELUTING IMPURITIES IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029170713.

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12

Tang, Jianhua. "Development of a novel gradient chromatofocusing tandem mass spectometry technique for the determination of cationic compounds in biofluids identification of caspace 3 cleavage sites of nhe-1 by high performance liquid chromatography- mass spectrometry /." Cleveland, Ohio : Cleveland State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1247344073.

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Thesis (Ph. D.)--Cleveland State University, 2009.<br>Abstract. Title from PDF t.p. (viewed July 29, 2009). Includes bibliographical references (p. 105). Available online via the OhioLINK ETD Center and also available in print.

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13

Allegood, Jeremy Chadwick. "Application of liquid chromatography tandem mass spectrometry for the separation and quantitative analysis of sphingolipids." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42691.

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Sphingolipids are a highly diverse category of compounds that serve not only as components of biologic structures but also as regulators of numerous cell functions. Because so many of the structural features of sphingolipids influence their biological activity, there is a need for comprehensive methods for quantitation of as many individual subspecies as possible. This dissertation describes methods that have been developed and validated for the extraction, liquid chromatographic separation, identification and quantitation of sphingolipids by electrospray ionization (ESI), tandem mass spectr

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14

Lucas, Natasha. "The Analysis of Recreational Drugs in Biological Specimens Using Liquid Chromatography Mass Spectrometry." The University of Waikato, 2008. http://hdl.handle.net/10289/2471.

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In the last few years, the prevalence of legal party pills in New Zealand has risen dramatically. These pills contain new piperazine designer drugs, two of the more common being 1-benzylpiperazine (BZP) and m-trifluoromethylphenylpiperazine (TFMPP). This thesis describes an optimised LC-MS/MS method for the detection of BZP and TFMPP in whole blood, using an automated solid phase extraction (SPE) for sample clean-up. The method was validated on three different days using five replicate samples each day. The standard curve was linear from 7 - 7000 ng/mL for BZP and 10 - 10,000 ng/mL for TFMPP,

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15

Alberts, P. "Applicatins of liquid chromatography-tandem mass spectrometry to wine analysis : targeted analysis and compound identification." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71693.

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Thesis (PhD)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The wine industry is an important sector of agriculture and wine analysis forms the basis of assessing compliance of its commodities with regulatory standards and research in this field. Liquid chromatography (LC) is extensively used for the determination of a wide range of nonvolatile wine components, but conventional detectors impose performance limitations on the technique that prevents its application to sophisticated analytical problems. In particular, conventional detectors for LC often lack the sensitivity and specif

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16

Zhou, Feng. "Protein characterization by capillary isoelectric focusing electrophoresis, reversed phase liquid chromatography and mass spectrometry." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 103 p, 2008. http://proquest.umi.com/pqdweb?did=1456289241&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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17

Kakarla, Raghavi. "LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIC ANALYSIS OF CLINICALLY AND PHARMACOLOGICALLY RELEVANT MOLECULES." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1576196451854014.

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18

Lo, Fu-kiu, and 盧富嬌. "Multi-residue analysis of pesticides using on-line two dimension liquid chromatography-tandem mass spectrometry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47869951.

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This thesis begins with an examination of the feasibility of using the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method, and its variants, for the co-extraction of nonpolar and polar pesticides, including highly polar quaternary ammonium salts (QA) and organophosphates (OP). QuEChERS was performed on a mixture of nine different chemical classes of pesticides, with triphenyl phosphate (TPP) as the internal standard, on aqueous Chinese lettuce samples, at 0.1 and 1.0 μg/mL levels. QuEChERS provided superior sample recovery and precision (RSD) for nonpolar pesticides than

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19

Moberg, My. "Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7071.

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20

Fong, Bonnie Mei Wah. "Development and applications of liquid chromatography-tandem mass spectrometry in clinical areas." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1530.

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21

Fernández, Albert Francesc. "Machine learning methods for the analysis of liquid chromatography-mass spectrometry datasets in metabolomics." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/283980.

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Liquid Chromatography-Mass Spectrometry (LC/MS) instruments are widely used in Metabolomics. To analyse their output, it is necessary to use computational tools and algorithms to extract meaningful biological information. The main goal of this thesis is to provide with new computational methods and tools to process and analyse LC/MS datasets in a metabolomic context. A total of 4 tools and methods were developed in the context of this thesis. First, it was developed a new method to correct possible non-linear drift effects in the retention time of the LC/MS data in Metabolomics, and it was co

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22

Ansong, Godfred. "Analysis of plant polyphenols by high performance liquid chromatography/mass spectrometry and protein binding." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1083081905.

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23

Hyllbrant, Forngren Benita. "Liquid chromatography-mass spectrometry in the analysis of radiolabelled compounds for positron emission tomography." Doctoral thesis, Uppsala University, Department of Chemistry, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1075.

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<p>Methods for liquid chromatography-mass spectrometry (LC/MS) with electrospray ionization (ESI) have been developed for the determination of specific radioactivity and for metabolic studies of radiolabelled compounds used in positron emission tomography (PET). These compounds often provide an analytical challenge mainly due to their low concentrations in complex sample matrices.</p><p>The effect on sensitivity using different mobile phase additives, such as trifluoroacetic acid and formic acid, was investigated. The ESI-MS response shows higher stability and sensitivity when volatile additiv

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24

Kung, An-Wen. "Development and application of liquid chromatography-mass spectrometry for the analysis of nucleic acids." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20841/.

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25

Bian, Juan. "Liquid Chromatography and Mass Spectrometry Based Analytical Method Development Towards Fast and Sensitive Analysis." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557242729134942.

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26

Benson, Andrew James. "High-performance liquid chromatography (HPLC) and high-performance liquid chromatography mass spectrometry (HPLC/MS) for the analysis of date rape drugs." FIU Digital Commons, 2002. http://digitalcommons.fiu.edu/etd/1602.

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The drugs studied in this work have been reportedly used to commit drug-facilitated sexual assault (DFSA), commonly known as "date rape". Detection of the drugs was performed using high-performance liquid chromatography with ultraviolet detection (HPLC/UV) and identified with high performance-liquid chromatography mass spectrometry (HPLC/MS) using selected ion monitoring (SIM). The objective of this study was to develop a single HPLC method for the simultaneous detection, identification and quantitation of these drugs. The following drugs were simultaneously analyzed: Gamma-hydroxybutyrate (GH

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27

Kalili, Kathithileni Martha. "Comprehensive two-dimensional liquid chromatographic analysis of phenolics." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85749.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Phenolic chemistry is quite complex; natural phenolic compounds vary widely in terms of size and chemical properties. The high structural diversity within this family presents severe analytical challenges. High performance liquid chromatography (HPLC) is the preferred method for phenolic analysis; however, conventional HPLC methods offer limited separation power and often provide incomplete separation of the large number of components present in natural phenolic extracts. Multi-dimensional chromatographic techniques have pr

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28

Atkinson, Ian E. "Mass Spectrometric Analysis of Environmental Contaminants, Protein Structure and Expression." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1231174291.

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29

Ford, Michael James. "Modern mass spectrometric techniques applied to occupational hygiene analysis." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268553.

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30

Egan, Martin Joseph. "Analysis of polyhydroxyalkaloids in plant extracts by chromatography and mass spectrometry : including sequential tandem MS." Thesis, University of Greenwich, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324932.

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31

Ramström, Margareta. "Analysis of Complex Biological Samples using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Doctoral thesis, Uppsala University, Analytical Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5729.

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<p>Studies of protein and peptide expression are vital in order to understand complex biological systems. As demonstrated in this thesis, on-line packed capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS) is a useful analytical tool for such studies.</p><p>A proteomics method, based on global tryptic digestion and subsequent separation and detection of the peptides by LC-FTICR MS, was developed for qualitative analysis of body fluids. Initial experiments on cerebrospinal fluid (CSF) provided results that were comparable or superior to those

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32

Evans, Charles Robert Jorgenson James W. "Multidimensional liquid chromatography coupled to mass spectrometry for the analysis of complex mixtures of proteins." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1468.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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33

Troster, Charles Micah Smolkin. "Trace analysis of cyclophosphamide and its metabolites in urine by liquid chromatography-tandem mass spectrometry." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29263.

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Cyclophosphamide (CP) is an antineoplastic drug used to treat a wide variety of cancers and immune disorders. CP is also a highly toxic alkylating agent, classified as an IARC Group 1 carcinogen. Workers in health-care environments are vulnerable to occupational exposure to CP, primarily via inhalation and dermal absorption. CP is a prodrug; both its therapeutic effectiveness and toxicity are activated through metabolism. To date, however, no study measuring occupational exposure to CP has successfully analyzed its metabolites. The main objective of this work was to develop an analytical metho

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34

Lam, Pui-yu, and 林沛瑜. "Multidimensional liquid chromatography for the analyses of hydrophilicand hydrophobic components in mass spectrometry-based proteomics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45960392.

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35

Blanchette, Maxime. "Development of a method for the LCMS determination of vicinal diketones in beer." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100772.

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No existent analytical method allowed the determination of the vicinal diketones (VDK), 2,3-butanedione (diacetyl) and 2,3-pentanedione, by liquid chromatography/mass spectrometry (LC/MS). An LC/MS method was developed for the simultaneous determination of diacetyl and 2,3-pentanedione in beer. A method allowing the determination of the amino acids (AA) related to the formation of VDK during fermentation was also developed. VDK were derivatized with o-phenylenediamine (OPDA) to form quinoxaline compounds. The reaction of VDK with OPDA was studied to optimize reaction time. Conversion of the di

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36

Quadri, Syeda. "Metabolomics Investigation of Glyceollins by On-Line Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry and Fungal Metabolite Identification by Thermal Desorption Analysis Coupled with Gas Chromatography-Mass Spectrometry." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1701.

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Metabolomics is an emerging field that entails the detailed characterization of the ensemble of metabolites produced by living organisms; subfields include drug metabolism and natural environmental toxin production. The first part of the dissertation pursued metabolism of glyceollins, i.e., isoflavones produced by soybeans, that are potential cancer therapy agents. In vivo glyceollin metabolites produced in rats were investigated by on-line Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. An odd-electron fragment ion at m/z 148, formed in violation of the even-electron r

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37

Wink, Carina S. D. Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "1,2-diphenylethylamine designer drugs metabolism studies and toxicological analysis using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry coupled to low and high resolution-mass spectrometry / Carina S. D. Wink. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1104733323/34.

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38

Ma, Wai Tang. "Analysis of polar nitroaromatics in groundwater by using solid-phase extraction and liquid chromatography-mass spectrometry." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/581.

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39

Wang, Tongwen. "Hyphenated HPLC-MS technique for analysis of compositional monosaccharides of transgenic corn glycoprotein and characterization of degradation products of diazinon, fonofos and aldicarb in various oxidation systems." Diss., Rolla, Mo. : University of Missouri-Rolla, 2007. http://scholarsmine.mst.edu/thesis/pdf/WangTongwen_09007dcc804e975c.pdf.

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Thesis (Ph. D.)--University of Missouri--Rolla, 2007.<br>Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 23, 2008) Includes bibliographical references.

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40

Kim, Byungchul. "Analysis of Melamine and Cyanuric Acid by Liquid Chromatography with Diode Array Detection and Tandem Mass Spectrometry." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/pdf/KimB2009.pdf.

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41

Smiljanic, Danijela. "Mass Spectrometry Interfaced with Ion Mobility or Liquid Chromatography Separation for the Analysis of Complex Mixtures." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1323149449.

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42

Massey, Karen A., Anna M. Snelling, and Anna Nicolaou. "Quantitative analysis of surfactant deposits on human skin by liquid chromatography electrospray ionisation tandem mass spectrometry." Wiley, 2010. http://hdl.handle.net/10454/4574.

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no<br>Surfactants are commonly used as cleansing agents and yet there are concerns they may also have a role in skin irritation. Presently, the lack of suitable methods for quantitative and qualitative analysis of surfactant deposition on skin has hindered the in-depth investigation of such effects. Here, we report the application of reverse phase liquid chromatography electrospray ionisation mass spectrometry (LC/ESI-MS/MS) assays for two surfactants commonly used in consumer products, namely sodium lauryl ether sulphate (SLES) and laurylamidopropyl betaine (LAPB), to a baseline study aiming

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43

Narreddula, Venkateswara Reddy. "Development of novel derivatization reagents for analysis of isomeric fatty acids by liquid chromatography-mass spectrometry." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/136811/1/Venkateswara%20Reddy_Narreddula_Thesis.pdf.

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This project was a step forward in 'developing next-generation derivatization reagents for photodissociation mass spectrometry', an emerging mass spectrometry activation method for structural elucidation of lipid biomolecules. The method involves synthesis of photo labile derivatization reagents, derivatization with fatty acids and photodissociation of derivatives using 266 nm laser to elucidate subtle features of fatty acids. The thesis investigated the utility of fixed charge photo labile derivatives for identifying unusual fatty acids from lipid extract of vernix caseosa, and optimization o

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Lai, Yongquan. "Development and application of liquid chromatography mass spectrometry methods for the analysis and toxicity study of polybrominated diphenyl ether metabolites." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1437.

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Bottegal, Megan N. "The Development of High Performance Liquid Chromatography Systems for the Analysis of Improvised Explosives." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/154.

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Existing instrumental techniques must be adaptable to the analysis of novel explosives if science is to keep up with the practices of terrorists and criminals. The focus of this work has been the development of analytical techniques for the analysis of two types of novel explosives: ascorbic acid-based propellants, and improvised mixtures of concentrated hydrogen peroxide/fuel. In recent years, the use of these explosives in improvised explosive devices (IEDs) has increased. It is therefore important to develop methods which permit the identification of the nature of the original explosive fro

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46

Anumol, Tarun, Sylvain Merel, Bradley Clarke, and Shane Snyder. "Ultra high performance liquid chromatography tandem mass spectrometry for rapid analysis of trace organic contaminants in water." Chemistry Central, 2013. http://hdl.handle.net/10150/610118.

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BACKGROUND:The widespread utilization of organic compounds in modern society and their dispersion through wastewater have resulted in extensive contamination of source and drinking waters. The vast majority of these compounds are not regulated in wastewater outfalls or in drinking water while trace amounts of certain compounds can impact aquatic wildlife. Hence it is prudent to monitor these contaminants in water sources until sufficient toxicological data relevant to humans becomes available. A method was developed for the analysis of 36 trace organic contaminants (TOrCs) including pharmaceut

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47

Huang, Fan. "APPLICATION OF HIGH-RESOLUTION ACCURATE MASS (HRAM) MASS SPECTROMETRY FOR ANALYSIS OF LIGNIN MODEL COMPOUNDS AND THE POST-PRETREATMENT PRODUCTS." UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/74.

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Lignin, one of main components in the woody cell walls, is a complex heterogeneous biopolymer, which provides structural support and transportation of water in plants. It is highly recalcitrant to degradation (both chemically and environmentally) and protects cellulose from being degraded/hydrolyzed. Due to the structural complexity of native lignin, complete characterization and elucidation of lignin’s structure remains very challenging. The overarching goal of this work is to develop mass spectrometry based analytical methods to contribute to a better understanding of lignin structures. This

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48

Tolonen, A. (Ari). "Analysis of secondary metabolites in plant and cell culture tissue of Hypericum perforatum L and Rhodiola rosea L." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271610.

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Abstract Sensitive chromatographic methods were developed for the quantitative analysis of secondary metabolites in Hypericum perforatum (St. John's wort) and Rhodiola rosea (Golden root, rose root) extracts. Sample preparation methods were developed for plant, cell culture and biotransformation suspension matrixes. High performance liquid chromatography (HPLC) was used for the separation of analytes, and chromatographic data was acquired using photodiode array (PDA) detection or atmospheric pressure ionization mass spectrometry (API-MS). Ionization efficiencies with electrospray ionization (E

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De, Kock Neil. "The development of direct infusion mass spectrometry method for analysis of small metabolites in urine." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80213.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: This study focused on the development of an analytical method whereby creatinine, creatine and caffeine could be determined quantitatively. Urine is the preferred body fluid for the analysis of metabolites that the body excretes after administration of medicinal and illicit drugs. The detection of these metabolites depends on the volume of water the patient has drunk or, in criminal cases, the amount of water the suspect may deliberately add to their urine to dilute it. Creatinine, whose concentration in urine has been found to

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50

Allard, Erik. "Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110310.

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Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. This thesis describes several ways of doing so, including targeted analysis of selected metabolites and investigations of systematic metabolic differences between selected groups through pattern recognition. A method for exploring metabolic patterns in urine samples after intake of coffee or tea was developed. The methodology was later used wit

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