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Journal articles on the topic 'Lungs Radiation injuries'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Saburova, A. S., M. V. Filimonova, V. V. Yuzhakov, L. I. Shevchenko, N. D. Yakovleva, L. N. Bandurko, A. E. Koretskaya, N. K. Fomina, V. O. Saburov та A. S. Filimonov. "The influence of nitric oxide synthases inhibitor Т1023 on the development of radiation pneumofibrosis in rats". Radiatsionnaya Gygiena = Radiation Hygiene 13, № 1 (31 березня 2020): 60–67. http://dx.doi.org/10.21514/1998-426x-2020-13-1-60-67.

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The purpose of the work was to study the ability of the NOS inhibitor T1023 to prevent late radiation injuries. Methods: the effects of T1023 (75 mg / kg, once i.p. 30 minutes before the irradiation) on the development of post-radiation pulmonitis and pneumofibrosis in rats with thoracic exposure to g-radiation at a dose of 12.5 Gy were studied histopathologically and morphometrically. The results of the studies showed that there wasn’t a significant objective effect of T1023 on the development of early radiation-induced lung injuries (9 weeks after irradiation). But it prevented late radiatio

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DiCarlo, Andrea L. "Scientific research and product development in the United States to address injuries from a radiation public health emergency." Journal of Radiation Research 62, no. 5 (July 24, 2021): 752–63. http://dx.doi.org/10.1093/jrr/rrab064.

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Abstract The USA has experienced one large-scale nuclear incident in its history. Lessons learned during the Three-Mile Island nuclear accident provided government planners with insight into property damage resulting from a low-level release of radiation, and an awareness concerning how to prepare for future occurrences. However, if there is an incident resulting from detonation of an improvised nuclear device or state-sponsored device/weapon, resulting casualties and the need for medical treatment could overwhelm the nation’s public health system. After the Cold War ended, government investme

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Nudnov, N. V., V. M. Sotnikov, and V. V. Ledenev. "A new Method of Quantitative Estimation of Radiation-Induced Lung Damage in Oncological Patients on the CT in Dynamics." Medical Visualization, no. 5 (October 28, 2017): 56–65. http://dx.doi.org/10.24835/1607-0763-2017-5-56-65.

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Objective: to develop a methodology for quantitative assessment of changes in density parameters of pulmonary tissue on the basis of dynamic CT data, which makes it possible to assess the presence of the dependence of changes in lung tissue on the time elapsed after radiation therapy (RT), the dose and volume of irradiated pulmonary tissue.Materials and methods. Using the data collected by 11 patients with malignant lymphomas, we developed a new diagnostic technique for quantitative analysis, which is based on the analysis of the density of pulmonary tissue before and after RT in areas with a

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Khomutova, E. Y., P. V. Novikov, and A. S. Shatalov. "Possibilities of low-dose radiation therapy in the treatment of intrapulmonary injuries caused by COVID-19 infection." Medical Visualization 25, no. 1 (March 24, 2021): 27–34. http://dx.doi.org/10.24835/1607-0763-991.

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This paper examines the relevance of the use of a single irradiation of lungs in treatment of pneumonia caused by a new coronavirus infection. Clinical observations are presented that demonstrate perspectives in the treatment of this disease. Patients with severe pneumonia who were prescribed LD-RT (low-dose radiation therapy) at a dose of 0.5–1.5 Gy showed shorter recovery times and no complications. This method of treatment has shown its effectiveness in a number of studies from different countries, predicting success and economic benefits in its further use and study. A literature search co

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Eckersley, Martyn, Carla Goncalves, Dalip Kumar, and Saman Perera. "A case of a mobile intrathoracic foreign object." Trauma 22, no. 1 (October 15, 2019): 70–73. http://dx.doi.org/10.1177/1460408619880140.

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Penetrating chest trauma to children is rare in the UK, making up 0.8% of wounds to children. When it does occur, it often results in damage to mediastinal structures including but not limited to the heart, lungs and great vessels. Rarely foreign objects can be intrapericardial. We present the case of a 14-year-old boy who presented haemodynamically stable following pellet gun wound to the chest. Multi-modality imaging revealed the bullet to be in the pericardium without associated cardiothoracic injuries, confirmed following surgery. Although a multi-modality imaging approach was used in diag

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Ubysz, Dorota, Wojciech Giermaziak, and Aurelia Ostrowska. "Adverse Events During Hyperbaric Oxygen Therapy – Literature Review." Polish Hyperbaric Research 76, no. 3 (September 1, 2021): 45–66. http://dx.doi.org/10.2478/phr-2021-0016.

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Abstract As any other therapy method, hiperbaric oxygen therapy is connected with the risk of complications. The article is a review of the results of research on adverse events of hyperbaric oxygen therapy. The most common are: borotrauma of the middle ear, paranasal sinuses or lungs, oxygen toxicity can be pulmonary, ocular in extreme cases leading to cataracts, claustrophobia, pulmonary edema or hypoglycaemia. Research has shown that these events occur in the presence of high oxygen concentration or high pressure. Depending on the severity of complications, they are short-term not causing d

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Li, Bailong, Cheng Li, Mo Zhu, Youjun Zhang, Jicong Du, Yang Xu, Bin Liu, et al. "Hypoxia-Induced Mesenchymal Stromal Cells Exhibit an Enhanced Therapeutic Effect on Radiation-Induced Lung Injury in Mice due to an Increased Proliferation Potential and Enhanced Antioxidant Ability." Cellular Physiology and Biochemistry 44, no. 4 (2017): 1295–310. http://dx.doi.org/10.1159/000485490.

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Background/Aims: Radiation therapy is an important treatment for thoracic cancer; however, side effects accompanied with radiotherapy lead to limited tumor control and a decline in patient quality of life. Among these side effects, radiation-induced lung injury (RILI) is the most serious and common. Hence, an effective remedy for RILI is needed. Mesenchymal stromal cells (MSCs) are multipotent adult stem cells that have been demonstrated to be an effective treatment in some disease caused by tissue damage. However, unlike other injuries, RILI received limited therapeutic effects from implanted

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Burgess, Matthew, Franklin Valdera, David Varon, Esko Kankuri, and Kristo Nuutila. "The Immune and Regenerative Response to Burn Injury." Cells 11, no. 19 (September 29, 2022): 3073. http://dx.doi.org/10.3390/cells11193073.

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Burn are diverse and complex injuries that not only have local effects but also serious systemic consequences through severe and prolonged inflammatory response. They are caused by heat, electricity, friction, chemicals, or radiation and are commonly divided into superficial, superficial partial-, deep partial- and full-thickness injuries. The severity of the burn depends mainly on the size and depth of the injury but also on location, age, and underlying systemic diseases. A prolonged and strong immune response makes major burns even worse by causing multiple systemic effects including damage

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Davydkin, V. I. "PROFESSOR IVAN NIKIFOROVICH PIKSIN (to the 85th anniversary of the birth)." Grekov's Bulletin of Surgery 178, no. 6 (March 18, 2020): 80–82. http://dx.doi.org/10.24884/0042-4625-2019-178-6-80-82.

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The article is dedicated to the 85th birthday of the famous scientist, honored worker of science of the Russian Federation, honored worker of science of the Republic of Mordovia, honored doctor of the Republic of Mordovia, laureate of State prize, head of the scientific-pedagogical surgical school, doctor of medical Sciences professor Piksin Ivan Nikiforovich. I. N. Piksin is the author of fundamental studies of the biomedical effects of quantum radiation at the molecular, cellular and organismal levels in patients with acute destructive diseases of the lungs, purulent-septic diseases, lactati

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Vasil’ev, A. Yu, and I. S. Obelchak. "Multidetector computed tomography in the diagnosis of lesions of the main vessels for gunshot injury of the chest." Regional blood circulation and microcirculation 18, no. 1 (May 3, 2019): 31–38. http://dx.doi.org/10.24884/1682-6655-2019-18-1-31-38.

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Purpose – examine the possibilities of multislice computed tomangiography (MSCTA) in case of suspected damage to the great vessels in a chest gunshot fghting injury.Material and methods. A radiation survey of 130 wounded with gunshot injuries of the chest to assess the nature, diagnosis of gunshot injuries of the vascular bed.Results. Of the 130 wounded with gunshot wounds to the chest, 41 (31.5 %) of the injured had gunshot wounds to the chest were nonpenetrating, and 89 (68.5 %) had penetrating injuries. In 76 (58.4 %) patients with gunshot chest injuries, the nature of the wound was fragme

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Orlov, Yurii P., Sergey V. Sviridov, and Evgeny N. Kakulya. "Pathophysiological aspects of oxygen, hypoxia and free radical oxidation in critical conditions." Clinical nutrition and metabolism 2, no. 2 (April 15, 2021): 66–79. http://dx.doi.org/10.17816/clinutr88951.

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Oxygen is the main regulator of metabolic processes in the body not only in the context of normal physiology, but also in the development of various critical conditions. In recent years, the problem of pathogenesis of a number organs' and systems' diseases has been enriched by knowledge of the mechanism of damage to cellular structures. Oxygen turned out to be the main factor of damage the very oxygen, due to the lack of which cell death occurs. It turned out that the so-called reactive oxygen species having an unpaired electron have a biological effect, which, depending on the concentra

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Fliss, H., and M. Menard. "Rapid neutrophil accumulation and protein oxidation in irradiated rat lungs." Journal of Applied Physiology 77, no. 6 (December 1, 1994): 2727–33. http://dx.doi.org/10.1152/jappl.1994.77.6.2727.

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Exposure of lungs to high doses of ionizing radiation can initiate an injurious acute inflammatory response. We show that neutrophil content in the lungs of rats exposed to 10 Gy whole body gamma radiation increased threefold 4.5 h after irradiation and returned to normal by 24 h. Oxidized methionine in the proteins of the lungs, heart, liver, kidney, and jejunum increased significantly in 2 h. Treatment with the antioxidant dithiothreitol immediately after irradiation prevented methionine oxidation. Methionine oxidation was also observed after intrabronchial instillation of phorbol myristate

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Redaelli, Paola, Amando Gamba, Antonello Stefano Martino, and Michele Triggiani. "Unexpected Radiation-Induced Aortic Wall Thickening Requiring Composite Graft Technique during Off-Pump Coronary Artery Bypass Grafting." Case Reports in Surgery 2017 (2017): 1–2. http://dx.doi.org/10.1155/2017/3831749.

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Mediastinal radiation is commonly used to treat Hodgkin’s and non-Hodgkin’s lymphoma, lung and breast cancer. Cardiac complications after radiation therapy are well described, although rare. A large spectrum of injuries can occur, causing long term morbidity among survivors. We describe a case of post-actinic ascending aortic wall thickening that prevented saphenous vein proximal anastomosis and was successfully managed with aortic no-touch off-pump coronary artery bypass grafting (OPCAB), 25 years after radiation therapy for Hodgkin’s lymphoma.

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Wang, Bao-Zhong, Li-Ping Wang, Hui Han, Fang-Li Cao, Guang-Yao Li, Jun-Long Xu, Xiu-Wen Wang, and Le-Xin Wang. "Interleukin-17A antagonist attenuates radiation-induced lung injuries in mice." Experimental Lung Research 40, no. 2 (January 21, 2014): 77–85. http://dx.doi.org/10.3109/01902148.2013.872210.

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Wang, R., J. Rahimian, M. R. Girvigian, M. J. Miller, and L. Mariscal. "Quantitative Analysis of Stereotactic Body Radiation Therapy (SBRT)-Induced Lung Injuries." International Journal of Radiation Oncology*Biology*Physics 96, no. 2 (October 2016): E674. http://dx.doi.org/10.1016/j.ijrobp.2016.06.2315.

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Dykan, Iryna. "Radiation diagnostics of thoracic gunshot wounds." Radiation Diagnostics, Radiation Therapy, no. 2 (2020): 70–80. http://dx.doi.org/10.37336/2707-0700-2020-2-6.

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The frequency of thoracic injuries in the general structure of combat surgical trauma remains at the level of 7-12 % and unchanged from the time of the Second World War to the current armed conflicts. The overwhelming majority of them (up to 72 %) are shrapnel gunshot wounds. The formation of a gunshot wound occurs due to the action of a shock wave; a wounding projectile; energy of side impact and vortex wake. The shape, size, features of the wound canal are determined by the kinetic energy of the wounding agent and the physical properties of the damaged tissues. The lung parenchyma is loose a

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Chen, Zhiyuan, Bin Wang, Jiali Dong, Yuan Li, Shuqin Zhang, Xiaozhou Zeng, Huiwen Xiao, Saijun Fan, and Ming Cui. "Gut Microbiota-Derived l-Histidine/Imidazole Propionate Axis Fights against the Radiation-Induced Cardiopulmonary Injury." International Journal of Molecular Sciences 22, no. 21 (October 23, 2021): 11436. http://dx.doi.org/10.3390/ijms222111436.

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Radiation-induced cardiopulmonary injuries are the most common and intractable side effects that are entwined with radiotherapy for thorax cancers. However, the therapeutic options for such complications have yielded disappointing results in clinical applications. Here, we reported that gut microbiota-derived l-Histidine and its secondary metabolite imidazole propionate (ImP) fought against radiation-induced cardiopulmonary injury in an entiric flora-dependent manner in mouse models. Local chest irradiation decreased the level of l-Histidine in fecal pellets, which was increased following feca

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Yadav, Marshleen, Sagar Bhayana, Joseph Liu, Lanchun Lu, Jason Huang, Ya Ma, Zahida Qamri, et al. "Two-miRNA–based finger-stick assay for estimation of absorbed ionizing radiation dose." Science Translational Medicine 12, no. 552 (July 15, 2020): eaaw5831. http://dx.doi.org/10.1126/scitranslmed.aaw5831.

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Nuclear radiation and radioactive fallouts resulting from a nuclear weapon detonation or reactor accidents could result in injuries affecting multiple sensitive organs, defined as acute radiation syndrome (ARS). Rapid and early estimation of injuries to sensitive organs using markers of radiation response is critical for identifying individuals who could potentially exhibit ARS; however, there are currently no biodosimetry assays approved for human use. We developed a sensitive microRNA (miRNA)–based blood test for radiation dose reconstruction with ±0.5 Gy resolution at critical dose range. R

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Maznyk, N. O., T. S. Sypko, V. P. Starenkyi, I. M. Hukova, S. V. Artiukh, and L. V. Cherkasko. "Features of cytogenetic effects in oncological patients during radiotherapy with prior radiation exposure." Український радіологічний та онкологічний журнал 29, no. 4 (December 23, 2021): 48–64. http://dx.doi.org/10.46879/ukroj.4.2021.48-64.

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Background. Radiotherapy can be used numerous times for treating oncological patients as one of the most effective ways of fighting against cancer. However, there is limited data on the effect of prior radiation exposure on the further development of cytogenetic alterations under the influence of radiological factors. Primary radiation treatment, as well as the second one, is an example of a complex scenario of fractionated irradiation, examination of which is of fundamental and practical importance for understanding complex processes of formation and elimination of cytogenetic markers of radi

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Wan, Xinlong, Xuan Shi, Mengke Li, Qing Chen, Chang Xue, Guanghui Li, Yeke Huang, et al. "The Protective Effects and Mechanism of Doxepin on Radiation–Induced Lung Injury in Rats." Dose-Response 20, no. 2 (April 2022): 155932582211071. http://dx.doi.org/10.1177/15593258221107193.

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Radiation-induced lung injuries (RILI) is one of the serious complications of radiotherapy posed by the damage of alveolar cells and inflammation over-reaction. We aimed to investigate the potential protective effects of doxepin on RILI (20 Gy total dose at 3 Gy/min of X-ray irradiation), as well as its underlying mechanism. For animal experiments, such parameters as Immunohistochemistry and hematoxylin and eosin (H&E) staining, WBC (white blood cell), CRP (C-reactive protein), Western blot, and q-PCR were detected. The results indicated that both survival status and weight increase of irr

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Wang, Kai-Xuan, Wen-Wen Cui, Xu Yang, Ai-Bin Tao, Ting Lan, Tao-Sheng Li, and Lan Luo. "Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects." Cells 10, no. 2 (February 1, 2021): 294. http://dx.doi.org/10.3390/cells10020294.

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Radiation therapy for cancers also damages healthy cells and causes side effects. Depending on the dosage and exposure region, radiotherapy may induce severe and irreversible injuries to various tissues or organs, especially the skin, intestine, brain, lung, liver, and heart. Therefore, promising treatment strategies to mitigate radiation injury is in pressing need. Recently, stem cell-based therapy generates great attention in clinical care. Among these, mesenchymal stem cells are extensively applied because it is easy to access and capable of mesodermal differentiation, immunomodulation, and

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Chapel, Alain, Alexandra Semont, Sabine Francois, Moubarack Mouiseddine, and Dominique Thierry. "Human Mesenchymal Stem Cells (MSC) Home at Injured Sites after Local Irradiation and Contribute To Reduce Radiation-Induced Intestinal Lesion." Blood 106, no. 11 (November 16, 2005): 1691. http://dx.doi.org/10.1182/blood.v106.11.1691.1691.

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Abstract Some patients who undergo radiotherapy may develop side effects that can be life threatening. Tissue complications can result in functional alterations of organs caused by radiation-induced stem cell depletion. Stem cell therapy is a promising approach to improve radiotherapy-enhanced tissue complications. The multipotential of Mesenchymal Stem Cells (MSC), their easy isolation and high ex vivo expansive capacity make these cells good candidates for replenishment of the depleted stem cell compartment during radiotherapy. In this study, we make the assumption that radiation-induced nor

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Kahn, Johannes, David Kaul, Georg Böning, Roman Rotzinger, Patrick Freyhardt, Philipp Schwabe, Martin Maurer, Diane Renz, and Florian Streitparth. "Quality and Dose Optimized CT Trauma Protocol – Recommendation from a University Level-I Trauma Center." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 189, no. 09 (June 26, 2017): 844–54. http://dx.doi.org/10.1055/s-0043-108996.

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Purpose As a supra-regional level-I trauma center, we evaluated computed tomography (CT) acquisitions of polytraumatized patients for quality and dose optimization purposes. Adapted statistical iterative reconstruction [(AS)IR] levels, tube voltage reduction as well as a split-bolus contrast agent (CA) protocol were applied. Materials and Methods 61 patients were split into 3 different groups that differed with respect to tube voltage (120 – 140 kVp) and level of applied ASIR reconstruction (ASIR 20 – 50 %). The CT protocol included a native acquisition of the head followed by a single contras

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Manouchehr Aghajanzadeh, Ali Alasvand Lahbar, Mohammad Reza Asgari, Ramin Ebrahimian, Ali Alavi Fomani, Azita Tangestaninejad, and Yousha Pooramadi. "Comparative study of the need for re-intervention after chest tube remove in two groups with and without chest x-ray in Patients Admitted into Razi and Poursina hospital in Rasht city." International Journal of Biological and Pharmaceutical Sciences Archive 2, no. 1 (September 30, 2021): 157–63. http://dx.doi.org/10.53771/ijbpsa.2021.2.1.0050.

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Introduction: The most common types of injuries following blunt or sharp trauma of lungs and the pleural space are pneumothorax, hemothorax and hemopneumothorax, which in most cases are resolved through supportive care and thoracostomy (use of chest tubes). Removal of the CT (chest tube) can result in complication such as pneumothorax and accumulation of fluid in the pleural space. Despite the lack of a standard guideline regarding the management of patients post CT removal, it is advised to procure a CXR as a means of a conservative approach. However, most of the findings acquired from the po

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Yue, Weisheng, Guilin Zhang, Ping Liu, Jianqi Sun, Yeukuang Hwu, Jung Ho Je, Mingguang Tan, and Yan Li. "Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 262, no. 2 (September 2007): 304–12. http://dx.doi.org/10.1016/j.nimb.2007.05.032.

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Kadivar, Fatemeh, Gholamhassan Haddadi, Mohammad Amin Mosleh-Shirazi, Fatemeh Khajeh, and Alireza Tavasoli. "Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats." Reports of Practical Oncology & Radiotherapy 25, no. 2 (March 2020): 206–11. http://dx.doi.org/10.1016/j.rpor.2019.12.023.

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Popova, I. E., L. T. Khamidova, I. E. Goncharova, V. M. Abuchin, R. Sh Muslimov, T. G. Barmina, E. A. Tarabrin, I. E. Selina, M. K. Nanoyan, and O. A. Chernysheva. "Radiation diagnostics of injuries and complications with a blind penetrating wound of the chest received from a construction and installation gun." Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH), no. 1 (February 3, 2022): 99–110. http://dx.doi.org/10.20340/vmi-rvz.2022.1.case.4.

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On the example of a clinical case, the possibilities of radiation diagnosis of a rare type of injury received from a construction and installation gun are shown. The modern possibilities of radiation diagnostics in the detection of injuries and complications in a gunshot wound of the chest are shown. Ultrasound data on the presence of intrapleural contents allowed us to determine the penetrating nature of the wound. The data obtained by polypositional chest radiography gave an idea of the localization and size of the foreign body. During chest CT, an accurate anatomical characteristic of the w

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Kubo, K., T. Kimura, H. Sakaguchi, N. Imano, H. Kawabata, Y. Takeuchi, Y. Doi, et al. "Computed Tomographic Appearance of Radiation Injuries in Lung After Two Prescribed Dose of 48Gy With Stereotactic Body Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics 93, no. 3 (November 2015): E421. http://dx.doi.org/10.1016/j.ijrobp.2015.07.1620.

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Cogno, Nicolò, Roman Bauer, and Marco Durante. "An Agent-Based Model of Radiation-Induced Lung Fibrosis." International Journal of Molecular Sciences 23, no. 22 (November 11, 2022): 13920. http://dx.doi.org/10.3390/ijms232213920.

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Early- and late-phase radiation-induced lung injuries, namely pneumonitis and lung fibrosis (RILF), severely constrain the maximum dose and irradiated volume in thoracic radiotherapy. As the most radiosensitive targets, epithelial cells respond to radiation either by undergoing apoptosis or switching to a senescent phenotype that triggers the immune system and damages surrounding healthy cells. Unresolved inflammation stimulates mesenchymal cells’ proliferation and extracellular matrix (ECM) secretion, which irreversibly stiffens the alveolar walls and leads to respiratory failure. Although a

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Lierova, Anna, Jitka Kasparova, Alzbeta Filipova, Jana Cizkova, Lenka Pekarova, Lucie Korecka, Nikola Mannova, Zuzana Bilkova, and Zuzana Sinkorova. "Hyaluronic Acid: Known for Almost a Century, but Still in Vogue." Pharmaceutics 14, no. 4 (April 11, 2022): 838. http://dx.doi.org/10.3390/pharmaceutics14040838.

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Hyaluronic acid (HA) has a special position among glycosaminoglycans. As a major component of the extracellular matrix (ECM). This simple, unbranched polysaccharide is involved in the regulation of various biological cell processes, whether under physiological conditions or in cases of cell damage. This review summarizes the history of this molecule’s study, its distinctive metabolic pathway in the body, its unique properties, and current information regarding its interaction partners. Our main goal, however, is to intensively investigate whether this relatively simple polymer may find applica

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Zhang, Chunyang, Yan Zhu, Ji Wang, Lisheng Hou, Wei Li, and Huaijie An. "CXCR4-Overexpressing Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Radiation-Induced Lung Injury." Stem Cells International 2019 (February 5, 2019): 1–12. http://dx.doi.org/10.1155/2019/2457082.

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Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). Previous studies have demonstrated that MSCs overexpressing Chemokine (C-X-C motif) receptor 4 (CXCR4) could increase the quantity of transplanted cells to local tissues. In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. C57BL mice received single dose of thoracic irradiation with 13 Gy of X-rays and then were administered saline, control HUMSCs, or CXCR4-overexpressing HUMSCs via tail

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Sagindikova, G. E., E. A. Kogan, and T. E. Shakhanov. "Mortality and morbidity of chronic lung disease and its morphological features in population of Semipalatinsk region." PULMONOLOGIYA, no. 3 (June 28, 2007): 87–92. http://dx.doi.org/10.18093/0869-0189-2007-0-3-87-92.

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This work was aimed to study prevalence, morbidity, mortality and morphological features of chronic respiratory pathology (CRP) in population living for a long time at Semipalatinsk region contaminated with radioactive products. We analyzed healthcare reports on prevalence, mortality and morbidity of CRP in population of Semipalatinsk region from 1969 to 2003 and questioned 7 274 residents of Semipalatinsk region using a special ly developed screening questionnaire. The latter considered the radiation related route and clinical status of the person. We have also analysed 631 autopsy reports of

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Fan, Ming, Lawrence B. Marks, Donna Hollis, Gunilla G. Bentel, Mitchell S. Anscher, Gregory Sibley, R. Edward Coleman, Ronald J. Jaszczak, and Michael T. Munley. "Can We Predict Radiation-Induced Changes in Pulmonary Function Based on the Sum of Predicted Regional Dysfunction?" Journal of Clinical Oncology 19, no. 2 (January 15, 2001): 543–50. http://dx.doi.org/10.1200/jco.2001.19.2.543.

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PURPOSE: To determine whether changes in whole-lung pulmonary function test (PFT) values are related to the sum of predicted radiation therapy (RT)-induced changes in regional lung perfusion. PATIENTS AND METHODS: Between 1991 and 1998, 96 patients (61% with lung cancer) who were receiving incidental partial lung irradiation were studied prospectively. The patients were assessed with pre- and post-RT PFTs (forced expiratory volume in one second [FEV1] and diffusion capacity for carbon monoxide [DLCO]) for at least a 6-month follow-up period, and patients were excluded if it was determined that

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Mansour, Somya Z., Fatma S. M. Moawed, Monda M. M. Badawy, and Hebatallah E. Mohamed. "Boswellic Acid Synergizes With Low-Level Ionizing Radiation to Modulate Bisphenol Induced-Lung Toxicity in Rats by Inhibiting JNK/ERK/c-Fos Pathway." Dose-Response 18, no. 4 (October 1, 2020): 155932582096959. http://dx.doi.org/10.1177/1559325820969597.

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Bisphenol A (BPA) is a low molecular weight chemical compound that has a deleterious effect on the endocrine system. It was used in plastics manufacturing with injurious effects on different body systems. Occupational exposure to low-level ionizing radiation (<1 Gy) is shown to attenuate an established inflammatory process and therefore enhance cell protection. Therefore, the objective of this study was to investigate the protective effect of boswellic acid (BA) accompanied by whole-body low-dose gamma radiation (γ-R) against BPA-induced lung toxicity in male albino rats. BPA intoxication i

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Kursova, L. V., A. G. Konoplyannikov, V. V. Pasov, I. N. Ivanova, M. V. Poluektova, and O. A. Konoplyannikova. "Possibilities for the Use of Autologous Mesenchymal Stem Cells in the Therapy of Radiation-Induced Lung Injuries." Bulletin of Experimental Biology and Medicine 147, no. 4 (April 2009): 542–46. http://dx.doi.org/10.1007/s10517-009-0538-7.

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Fleming, Robert E., and Michael Kasper. "ALVEOLAR EPITHELIAL REPAIR BY TYPE II PNEUMOCYTES IN THE RADIATION-INJURED RAT LUNG. † 2297." Pediatric Research 39 (April 1996): 386. http://dx.doi.org/10.1203/00006450-199604001-02322.

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OGASAWARA, NOBUHIKO, KAZUYOSHI SUGA, YUICHI KARINO, and NAOFUMI MATSUNAGA. "Perfusion Characteristics of Radiation-Injured Lung on Gd-DTPA-Enhanced Dynamic Magnetic Resonance Imaging." Investigative Radiology 37, no. 8 (August 2002): 448–57. http://dx.doi.org/10.1097/00004424-200208000-00006.

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Velazquez, M., and D. P. Schuster. "Effect of regional pulmonary blood flow on extravascular lung water measurements with PET." Journal of Applied Physiology 65, no. 3 (September 1, 1988): 1267–73. http://dx.doi.org/10.1152/jappl.1988.65.3.1267.

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We examined the effect of regional pulmonary blood flow (PBF) on lung water measurements made with a blood-borne label (15O-water) and positron emission tomography (PET) in five dogs. The total lung water (TLW) content of a lung region obtained at equilibrium after intravenous injection of 15O-water (TLW-water) was compared with calculations made from lung density measurements (TLW-density) also obtained with PET. These latter measurements are proportional to the tissue attenuation of radioactivity originating from an external source encircling the animal and are independent of PBF. Comparison

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Tatomir, Jovanka. "Procedure zdravstvene nege pacijenta sa opekotinskom traumom / Procedures health care of the patient with burns trauma." SESTRINSKI ŽURNAL 3, no. 1 (November 1, 2016): 48. http://dx.doi.org/10.7251/sez0116048t.

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The burns are tissue damage caused under the influence of pathogenic amounts of heat, chemicals, electricity or radiation of different bodies.Etiological factors generally can be divided into four groups: thermal, chemical, electrical and radiation burns.Tissue damage is directly related to high temperature and length of exposure to harmful agents. The higher the temperature and longer works, the damage was more severe. Etiologic agents can cause minor injuries in the form of erythema of the skin, and severe destruction of body parts or the whole organism. System changes occur and are particul

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AL-Suhbani, Musherah, Saif Serag, Nor El Houda Baghous, and Chakir El Mahjoub. "Evaluation the Impact of Changing Patient Thickness on Treatment Dose Amount Given to Injured Area." Open Access Macedonian Journal of Medical Sciences 10, B (September 27, 2022): 2118–23. http://dx.doi.org/10.3889/oamjms.2022.10760.

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Radiation therapy provides an appropriate radiation dose to tumors. The proportion of this dose varies according to the injured part and its location. Targeting the part affected by the tumor with an appropriate radiation dose requires high accuracy in measuring from the radiation source to the patient and the amount of dose. This treatment was applied using digital linear accelerators and computers to treat the tumor with radiation. In most cases, it is used chemotherapy, one of the standard cancer treatments. However, those doses affect the patient as it leads to loss of appetite, which nega

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Zheng, Yijun, and Duming Zhu. "Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/5806057.

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Since it was proposed in 2007, molecular hydrogen therapy has been widely concerned and researched. Many animal experiments were carried out in a variety of disease fields, such as cerebral infarction, ischemia reperfusion injury, Parkinson syndrome, type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, stress ulcer, acute sports injuries, mitochondrial and inflammatory disease, and acute erythema skin disease and other pathological processes or diseases. Molecular hydrogen therapy is pointed out as there is protective

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Saini, Rashmi, Savita Verma, Abhinav Singh, and Manju Lata Gupta. "Role of Active Principles of Podophyllum hexandrum in Amelioration of Radiation Mediated Lung Injuries by Reactive Oxygen/Nitrogen Species Reduction." CellBio 02, no. 03 (2013): 105–16. http://dx.doi.org/10.4236/cellbio.2013.23012.

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Wen, Sicheng, Mark Dooner, Elaine Papa, Michael Del Tatto, Mandy Pereira, Theodor Borgovan, Yan Cheng, et al. "Biodistribution of Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Radiation Injury Bone Marrow Murine Model." International Journal of Molecular Sciences 20, no. 21 (November 2, 2019): 5468. http://dx.doi.org/10.3390/ijms20215468.

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We have previously shown that injury induced by irradiation to murine marrow can be partially or completely reversed by exposure to human or murine mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs). Investigation of the biodistribution of EVs in vivo is essential for understanding EV biology. In this study, we evaluated the DiD lipid dye labeled MSC-EV biodistribution in mice under different conditions, including different MSC-EV doses and injection schedules, time post MSC-EV injection, and doses of radiation. DiD-labeled MSC-EVs appeared highest in the liver and spleen; lower

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Hong, Zhen-Yu, Sung Ho Eun, Kwangwoo Park, Won Hoon Choi, Jung Il Lee, Eun-Jung Lee, Ji Min Lee, Michael D. Story, and Jaeho Cho. "Development of a small animal model to simulate clinical stereotactic body radiotherapy-induced central and peripheral lung injuries." Journal of Radiation Research 55, no. 4 (February 20, 2014): 648–57. http://dx.doi.org/10.1093/jrr/rrt234.

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Liu, Daming, Fanxuan Kong, Yong Yuan, Prem Seth, Weidong Xu, Hao Wang, Fengjun Xiao, et al. "Decorin-Modified Umbilical Cord Mesenchymal Stem Cells (MSCs) Attenuate Radiation-Induced Lung Injuries via Regulating Inflammation, Fibrotic Factors, and Immune Responses." International Journal of Radiation Oncology*Biology*Physics 101, no. 4 (July 2018): 945–56. http://dx.doi.org/10.1016/j.ijrobp.2018.04.007.

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Feng, Mingxiang, Miao Lin, Haining Zhou, Yunhe Zhu, Baishen Chen, Xin Ye, Chuoji Huang, Juncheng Zhang, and Chunxue Bai. "Clinical utility of circulating genetically abnormal cells within low-dose computed tomography lung cancer screening: A correlative MCPND trial study." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e15536-e15536. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15536.

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e15536 Background: Recent screening trial results using low-dose computed tomography (LDCT) have been shown to reduce lung cancer mortality in high-risk patients. However, high false-positive rates, inter-grader variability, and radiation injuries are challenging, and therefor highlight the necessity for complementary biomarkers. The diagnostic performance of circulating genetically abnormal cells (CACs) was respectively evaluated in samples collected from patients with pulmonary nodules before and after lung lobectomy within the Multicenter Chinese Pulmonary Nodule Detection (MCPND) trial. We

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Aliotta, Jason M., Mandy Pereira, and Peter J. Quesenberry. "Tissue-Specific Gene Expression of Marrow Cells Co-Cultured with Various Murine Organs." Blood 112, no. 11 (November 16, 2008): 388. http://dx.doi.org/10.1182/blood.v112.11.388.388.

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Abstract We have previously demonstrated that murine bone marrow cells co-cultured with lung opposite a cell-impermeable membrane express high levels of lung cell-specific genes (Aliotta et al, Stem Cells, 2007;25(9):2245–56). Greater changes in gene expression were noted in marrow cells co-cultured with radiation-injured lung. A factor smaller than the pore size of the cell-impermeable membrane (0.4μm) is responsible for these changes as cell-free conditioned media (CM) had a similar effect on co-cultured marrow cells. Lung-derived microvesicles were found to enter marrow cells in culture and

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Magnuson-Osborn, Teresia A., Claes Dahlgren, John H. Hartwig, and Thomas P. Stossel. "Human Plasma Gelsolin Inhibits Cellular Responses to Platelet Activating Factor (PAF)." Blood 106, no. 11 (November 16, 2005): 3568. http://dx.doi.org/10.1182/blood.v106.11.3568.3568.

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Abstract Gelsolin is a highly conserved intracellular actin-binding protein with an extracellular isoform named plasma gelsolin (pGSN). Relatively high (250 mg /L) blood concentrations of pGSN decrease in response to trauma, major surgery, sepsis, burns, ionizing radiation, and hyperoxia. Depletion of pGSN to a critical (~20%) level precedes and predicts complications of primary injuries such as lung permeability changes, ARDS, assisted ventilation and death. Administration of recombinant pGSN ameliorates such complications and reduces mortality in animal models. A proposed mechanism for pGSN’

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Moss, Nelson S., Brandon S. Imber, Kavya Prasad, Bae P. Chu, Arun Goel, David Aramburu-Nunez, Michael Bellamy, et al. "69. PERMANENT INTRACAVITARY Cs131 BRACHYTHERAPY FOR PREVIOUSLY-IRRADIATED RECURRENT BRAIN METASTASES: INITIAL CLINICAL AND RADIATION SAFETY EXPERIENCE." Neuro-Oncology Advances 2, Supplement_2 (August 2020): ii14. http://dx.doi.org/10.1093/noajnl/vdaa073.056.

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Abstract OBJECTIVE Recurrence of previously-irradiated brain metastases (BrM) presents a significant challenge. We describe our initial experience using salvage resection with Cs131 brachytherapy in previously-irradiated BrM. METHODS Between September 2019 and April 2020, 9 patients with recurrent BrM underwent maximally-safe metastatectomy. Following pathological confirmation of viable recurrence, cavities were implanted with permanent Cs131 brachytherapy (GammaTile, GT Medical Technologies). Prescribed dose was 60Gy at 5mm from the cavity. Postimplant dosimetry (V100) was calculated on posto

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Roper, Jason M., Sean C. Gehen, Rhonda J. Staversky, M. Christine Hollander, Albert J. Fornace, and Michael A. O'Reilly. "Loss of Gadd45a does not modify the pulmonary response to oxidative stress." American Journal of Physiology-Lung Cellular and Molecular Physiology 288, no. 4 (April 2005): L663—L671. http://dx.doi.org/10.1152/ajplung.00355.2004.

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It is well established that exposure to high levels of oxygen (hyperoxia) injures and kills microvascular endothelial and alveolar type I epithelial cells. In contrast, significant death of airway and type II epithelial cells is not observed at mortality, suggesting that these cell types may express genes that protect against oxidative stress and damage. During a search for genes induced by hyperoxia, we previously reported that airway and alveolar type II epithelial cells uniquely express the growth arrest and DNA damage ( Gadd) 45a gene. Because Gadd45a has been implicated in protection agai

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