Academic literature on the topic 'Lymphocyte precursors'

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Journal articles on the topic "Lymphocyte precursors"

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Thiele, D. L., and P. E. Lipsky. "Leu-Leu-OMe sensitivity of human activated killer cells: delineation of a distinct class of cytotoxic T lymphocytes capable of lysing tumor targets." Journal of Immunology 137, no. 4 (1986): 1399–406. http://dx.doi.org/10.4049/jimmunol.137.4.1399.

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Abstract Sensitivity to L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) was used to characterize the phenotype of human activated killer cells. Natural killer cells (NK) and the precursors of both the alloantigen-specific cytotoxic T lymphocytes (CTL) and the NK-like activated killer cells generated after stimulation with allogeneic cells were deleted from human peripheral blood lymphocytes by preincubation with Leu-Leu-OMe. It was noted, however, that cytotoxic lymphocytes could be generated from Leu-Leu-OMe-treated lymphocyte precursors after 2 to 6 days of culture with the nonspecific mitogen
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Zhuk, Ye A., and V. A. Galenok. "T-lymphocyte precursors in diabetics." Problems of Endocrinology 41, no. 2 (1995): 4–6. http://dx.doi.org/10.14341/probl11356.

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Patients with types I, II, and pancreatogenic diabetes mellitus were examined for the counts of T precursor cells using autorosette formation test in the presence of t-activin, an activator of T lymphocyte differentiation. The counts of T lymphocyte precursors in patients with type II and pancreatogenic diabetes were virtually the same as in normal subjects. Disorders of cellular immunity in type I diabetes mellitus were found to be associated with depletion of pre-T-lymphocytes. These changes were the most manifest in the decompensation phase (ketoacidosis state). The results may be useful in
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Peddie, Clare M., and Valerie J. Smith. "‘Lymphocyte-like’cells in ascidians: Precursors for vertebrate lymphocytes?" Fish & Shellfish Immunology 5, no. 8 (1995): 613–29. http://dx.doi.org/10.1016/s1050-4648(95)80045-x.

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Sanders, V. M., and F. E. Powell-Oliver. "Beta 2-adrenoceptor stimulation increases the number of antigen-specific precursor B lymphocytes that differentiate into IgM-secreting cells without affecting burst size." Journal of Immunology 148, no. 6 (1992): 1822–28. http://dx.doi.org/10.4049/jimmunol.148.6.1822.

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Abstract Previous studies have shown that early addition of a beta 2-adrenergic agonist to whole splenocyte cultures immunized with SRBC induced an increase in the number of cells secreting Ag-specific antibody. Because of the low frequency of Ag-specific B lymphocytes in these cultures, it has been difficult to determine the cellular mechanism by which this increase is produced. To gain insight into this cellular mechanism, the present study was designed to evaluate the responsiveness of TNP-specific B lymphocytes cultured at both high density and limiting dilution with keyhole limpet hemocya
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Griffiths, S. D., D. T. Goodhead, S. J. Marsden, et al. "Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis." Journal of Experimental Medicine 179, no. 6 (1994): 1789–97. http://dx.doi.org/10.1084/jem.179.6.1789.

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We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are relatively sensitive, but B cell precursors are ultrasensitive. This differential sensitivity is also observed with corticosteroid, etoposide, and cisplatin, all apoptosis-inducing drugs used in the treatment of leukemia and other cancers. Further, we show that x-rays and drugs induce the bulk of the B cell precursor population to undergo rapid apoptos
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Arvin, A. M., M. Sharp, S. Smith, et al. "Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype." Journal of Immunology 146, no. 1 (1991): 257–64. http://dx.doi.org/10.4049/jimmunol.146.1.257.

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Abstract Immunity to varicella-zoster virus (VZV), a member of the alpha-herpes virus family, exemplifies the host response to an ubiquitous human viral pathogen. In this investigation of the cytotoxic T lymphocyte (CTL) response to VZV, the depletion of CD4+ T lymphocytes made it possible to demonstrate CD8(+)-mediated cytotoxic function against autologous VZV-infected lymphoblastoid cells targets. CTL recognition of two major VZV proteins, the immediate early protein (IE62) and gp I, was demonstrated in limiting dilution cultures of T lymphocytes obtained from immune donors, stimulated with
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Kumagai‐Braesch, Makiko, Masahiro Satake, Olle Korsgren, Arne Andersson, and Erna Möller. "Characterization of cellular human anti‐porcine xenoreactivity." Clinical Transplantation 7, no. 3 (1993): 273–80. http://dx.doi.org/10.1111/j.1399-0012.1993.tb00917.x.

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The cellular xenoimmune reactivity of human responder cells reactive against porcine stimulator cells has been characterized. The xenogeneic mixed lymphocyte bulk culture reactivity is slightly lower than the allogeneic response but peak reactivity occurs with similar kinetics and secondary responses of primed lymphocytes are comparable. The xeno‐MLR was directed against pig MHC class II molecules as indicated by blocking using specific monoclonal antibodies. Production of IL‐2 was delayed and significantly lower in the xeno‐MLR. The low proliferative xenoresponse could not be restored by the
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Kiziroglu, F., and R. G. Miller. "In vivo functional clonal deletion of recipient CD4+ T helper precursor cells that can recognize class II MHC on injected donor lymphoid cells." Journal of Immunology 146, no. 4 (1991): 1104–12. http://dx.doi.org/10.4049/jimmunol.146.4.1104.

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Abstract Intravenous injection of semiallogeneic (C57BL/6XDBA/2)F1 lymphocytes into adult C57BL/6 recipient mice not only, as previously reported, reduces the recipients' cytotoxic T lymphocyte response in a subsequent in vitro mixed lymphocyte reaction against the injected cell type, but also reduces Th cell function in the same MLR. Thus lymphoid cells derived from the injected mice were greatly reduced in their ability to proliferate and to produce IL-2 in response to (C57BL/6XDBA/2)F1 stimulator cells in vitro, whereas third party responses were unaffected. This appears to be due to a redu
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Janssen, O., C. Nerl, and D. Kabelitz. "T cells in B-cell chronic lymphocytic leukemia: quantitative assessment of cytotoxic and interleukin-2-producing lymphocyte precursors by limiting dilution analysis." Blood 73, no. 6 (1989): 1622–26. http://dx.doi.org/10.1182/blood.v73.6.1622.1622.

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Abstract Controversy exists as to the functional capacity of T lymphocytes in patients with B-cell chronic lymphocytic leukemia (CLL). We have used a limiting dilution (LD) culture approach to quantitatively assess frequencies of proliferating lymphocyte precursors (PLP), cytotoxic lymphocyte precursors (CLP), and interleukin-2 (IL-2)-producing helper lymphocyte precursors (HLP). Unseparated mononuclear cells (MNC) or purified T cells (E+) and leukemic B cells (E-) were cocultured under LD conditions with irradiated OKT3 hybridoma cells in the absence (determination of HLP) or presence of reco
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Janssen, O., C. Nerl, and D. Kabelitz. "T cells in B-cell chronic lymphocytic leukemia: quantitative assessment of cytotoxic and interleukin-2-producing lymphocyte precursors by limiting dilution analysis." Blood 73, no. 6 (1989): 1622–26. http://dx.doi.org/10.1182/blood.v73.6.1622.bloodjournal7361622.

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Controversy exists as to the functional capacity of T lymphocytes in patients with B-cell chronic lymphocytic leukemia (CLL). We have used a limiting dilution (LD) culture approach to quantitatively assess frequencies of proliferating lymphocyte precursors (PLP), cytotoxic lymphocyte precursors (CLP), and interleukin-2 (IL-2)-producing helper lymphocyte precursors (HLP). Unseparated mononuclear cells (MNC) or purified T cells (E+) and leukemic B cells (E-) were cocultured under LD conditions with irradiated OKT3 hybridoma cells in the absence (determination of HLP) or presence of recombinant I
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Dissertations / Theses on the topic "Lymphocyte precursors"

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Jacobsen, Karen Ann. "Microenvironmental organization of B lymphopoiesis in mouse bone marrow : in vivo localisation of B lymphocyte precursors, molecular-interactions with stromal reticular cells, and macrophage-mediated deletion of apoptotic forms." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41346.

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The localisation of B lymphocyte precursor cells in mouse bone marrow and their associations with stromal reticular cells and macrophages have been investigated by in vivo radioimmunolabeling combined with light and electron microscope radioautography. Many early B lineage cells expressing the B220 glycoprotein prior to the expression of surface immunoglobulin and those regenerating after sub-lethal $ gamma$-irradiation, were located in bone-associated regions of femoral marrow. Labeled B220$ sp*$ lymphoid cells of undifferentiated morphology were closely associated with complex cytoplasmic pr
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Ellabban, Wael. "Studies on precursors of human intestinal intraepithelial lymphocytes." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289072.

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Parker, Mathew James David. "Control of growth and performance of precursor B lymphocytes." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614676.

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Kaminski, Eduardo Roman. "Cytotoxic T lymphocyte precursor frequencies (CTL-p) and their relevance to bone marrow transplantation." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46378.

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Liu, Jing. "Regulation of VH replacement in human immature B cells by B cell receptor (BCR)-mediated signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010p/liu.pdf.

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D'ARGEMONT, CATHERINE. "La beta-2-microglobuline : un facteur chimiotactique pour les precurseurs des lymphocytes t." Paris 6, 1990. http://www.theses.fr/1990PA066464.

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Nous avons etudie les mecanismes controlant la colonisation du thymus par les cellules precurseurs des lymphocytes t chez les mammiferes en considerant l'hypothese selon laquelle l'epithelium thymique secrete des facteurs chimiotactiques capables d'attirer les precurseurs hematopoietiques medullaires. Le surnageant de la lignee epitheliale thymique de rat it45-r1 contient une proteine chimiotactique, baptisee thymotaxine, capable d'attirer in vitro des cellules de moelle osseuse de rat presentant des caracteristiques de cellules lymphoides immatures susceptibles de se differencier en lymphocyt
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DOUAGI, IYADH. "Etude de l'engagement des precurseurs hematopoietiques et de leur differenciation en lymphocytes t et nk." Paris 6, 2001. http://www.theses.fr/2001PA066080.

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Les cellules qui composent le systeme hematopoietique presentent la particularite d'etre en constant renouvellement a partir de cellules souches hematopoietiques (csh) pendant toute la vie d'un individu. L'etude de ce systeme presente donc un interet majeur pour la comprehension des mecanismes cellulaires et moleculaires regissant l'engagement des precurseurs hematopoietiques dans les diverses voies de differenciations. De fait, la connaissance de la hierarchie ainsi que des precurseurs intermediaires entre la cellule souche et les cellules differenciees sont des pre-requis pour cette etude. D
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Maddila, Santhosh Chandar [Verfasser]. "Regulation of the opioid precursor proopiomelanocortin in lymphocytes in a rat model of inflammatory pain / Santhosh Chandar Maddila." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1068921897/34.

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Rizzuto, Gabrielle Ann. "Self-antigen specific CD8+ T cell precursor : frequency determines the quality of the anti-tumor immune response /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1621818951&sid=3&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Abduh, Maisa. "Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS371.

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Les lymphocytes T CD8+ spécifiques de l'antigène sont impliqués dans la réponse immunitaire adaptative et jouent un rôle essentiel dans la protection de l'hôte contre l'infection par des pathogènes intracellulaires. Cette protection de longue durée dépend de la génération de réponses lymphocytaires T CD8+ mémoires, hautement fonctionnelles en termes de fréquence et de fonctionnalité, après réinfection.Après présentation de l'antigène, une cellule T CD8 naïve subit une forte expansion clonale, générant une population hétérogène de cellules activées qui est dominée, au sommet de l'expansion, par
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Books on the topic "Lymphocyte precursors"

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Woodward, Jeremy Mark. A study of lymphocyte precursors within the murine intestinal epithelium. University of Birmingham, 2000.

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Bahiru, Gametchu, ed. Glucocorticoid receptor structure and leukemic cell responses. Springer-Verlag, 1995.

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Secker-Walker, Lorna M. Chromosomes and genes in acute lymphoblastic leukemia. Springer, 1997.

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Martin, Diego Raul *. Experimental studies of a potential immune tolerance mechanism that functionally deletes cytotoxic T lymphocyte precursors in adult mice. 1991.

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Bunch, Chris. Chronic leukaemia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0287.

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In the chronic leukaemias, leukaemogenesis occurs in two different cell types (and possibly even two different anatomical sites), leading to two very different forms of the disease: chronic myeloid leukaemia and chronic lymphocytic leukaemia. Chronic myeloid leukaemia is best thought of as a myeloproliferative disorder. It is a clonal disorder of the haematopoietic stem cell, leading to overproduction of the myeloid cells: neutrophils and their precursors, basophils and eosinophils. By contrast, chronic lymphocytic leukaemia can be viewed as a low-grade lymphoma. It is a clonal disorder of mat
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(Editor), Robert Peter Gale, and Dieter Hoelzer (Editor), eds. Acute Lymphoblastic Leukaemia (UCLA symposia on molecular and cellular biology). John Wiley & Sons Inc, 1990.

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Book chapters on the topic "Lymphocyte precursors"

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Kincade, Paul W., Kay Medina, Glennda Smithson, et al. "Life/Death Decisions in B Lymphocyte Precursors." In Molecular Biology of B-Cell and T-Cell Development. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4757-2778-4_10.

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Piantelli, S., G. Maccauro, P. Fassina, and A. Bukat. "Effect of TiO2 Ceramic Precursors on Human Lymphocyte Mitogenesis." In Bioceramics and the Human Body. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2896-4_52.

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Müller-Sieburg, C. E., N. Martina, and J. P. Wineman. "Pluripotent Stem Cells and Early B Lymphocyte Precursors in Mice." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76912-2_9.

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Lee, G., A. E. Namen, S. Gillis, and P. W. Kincade. "Recombinant Interleukin-7 Supports the Growth of Normal B Lymphocyte Precursors." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-74006-0_3.

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Imhof, B. A., M. A. Deugnier, T. Itoh, and J. P. Thiery. "T Lymphocyte Precursors Migrate Towards Chemotactic Peptides Secreted by Embryonic or Juvenile Thymus." In Advances in Experimental Medicine and Biology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5535-9_86.

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Melchers, Fritz, Dirk Haasner, Martin Streb, and Antonius Rolink. "B-Lymphocyte Lineage-Committed, IL-7 and Stroma Cell- Reactive Progenitors and Precursors, and Their Differentiation to B Cells." In Advances in Experimental Medicine and Biology. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3396-2_14.

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Wagner, H., and C. Hardt. "Heterogeneity of the Signal Requirements During the Primary Activation of Resting Lyt-2+ Cytotoxic T-Lymphocyte (CTL) Precursors into Clonally Developing CTL." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71152-7_18.

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Melchers, F. "B-lymphocyte-lineage Cells from Early Precursors to Ig-secreting Plasma Cells: Targets of Regulation by the myc/mad/max Families of Genes?" In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60801-8_2.

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Ceredig, R. "Major Histocompatibility-Restricted Cytolytic T-Lymphocyte Precursors from the Thymus of In Vivo Primed Mice: Increased Frequency and Resistance to Anti-Lyt-2 Antibody Inhibition." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71152-7_4.

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Melchers, Fritz, Steven R. Bauer, Christoph Berger, et al. "Precursor B Lymphocytes — Specific Monoclonal Antibodies and Genes." In Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-5803-0_11.

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Conference papers on the topic "Lymphocyte precursors"

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Cavalcante, Jéssica Moreira, Mauro Henrique Muniz Goursand, Douglas de Miranda Pires, Paula Clarke, and Fernanda Silveira de Oliveira. "LYMPHOCYTIC MASTOPHATY PRECEDING BILATERAL PRIMARY BREAST LYMPHOMA – CASE REPORT." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1011.

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Introduction: Lymphocytic mastopathy is a rare condition, responsible for 1% of all benign breast lesions, commonly associated to autoimmune disorders and diabetes (especially insulin-requiring diabetes). The differential diagnosis may be difficult, since the clinical and imaging aspects can mimic malignant disease. Some authors suggest that lymphocytic mastitis could be a precursor of primary breast lymphoma. However, other studies disagree with such correlation, presenting the mastopathy as a distinct diagnosis, but one of difficult differentiation from lymphoma. To avoid misdiagnosis, an ap
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Kieffer, N., L. Edelman, P. Edelman, C. Legrand, J. Breton-Gori us, and W. Vainchenker. "A MONOCLONAL ANTIBODY AGAINST AN ERYTHROID ONTOGENIC ANTIGEN IDENTIFIES GP IV ON HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643532.

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A murine monoclonal antibody (FA6-152), obtained by immunizing mice with fetal human erythrocytes agglutinated fetal but not adult erythrocytes and bound to both adultand fetal monocytes, platelets andreticulocytes. The antibody did not react with lymphocytes or granulocytes (P. Edelman et al., Blood, 1986, 67, 56). Fluorescent labeling of marrow cells and of in vitro BFU-E, CFU-GM and CFU-MK derivedcolonies revealed that the antigen defined by FA6 was absent from the granulocytic precursors and was detected on the megakaryo-cytic lineage at a later stage of differentiation than major platelet
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Cramer, Elisabeth M., F. John, William Vainchenker, and Janine Breton-Gorius. "PRODUCTION AND LOCALISATION OF ALPHA-GRANULE PROTEINS IN MATURING MEGAKARYOCYTES: AN OVERVIEW ON ULTRA-STRUCTURAL ASPECTS OF MEGAKARYOCYTE MATURATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642952.

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In order to study the production of α- granule proteins in maturing megakaryocytes, we used immunocytochemical techniques performed on cultured and enriched bone marrow megakaryocytes. Cultures were prepared from bone marrow CFU-MK with the methylcellulose and plasma clot techniques. Preparation of bone marrow megakaryocytes was carried out from human or pig rib marrow separated on percoll gradient and counterflow centrifugation. Megakaryocyte preparations were 90$ pure and represented 85$ of those in the whole marrow. Activation was prevented with prostacyclin and prefixation with low concent
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