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Journal articles on the topic 'Lymphocytes of peripheral blood'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Lucivero, G., G. Pierucci, and L. Bonomo. "Lymphocyte subsets in peripheral blood and pleural fluid." European Respiratory Journal 1, no. 4 (1988): 337–40. http://dx.doi.org/10.1183/09031936.93.01040337.

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We have examined the distribution of B and T lymphocytes, T-cells with helper/inducer (T4+) or suppressor/cytotoxic (T8+) phenotypes and a subset of cells with natural killer (NK) activity and positive for the Leu 7 (HNK-1) surface antigen in peripheral blood and in lymphocyte-rich pleural effusions of patients with tuberculosis or malignancies (mesothelioma and lung cancer with pleural metastasis). In individual patients, the percentages of T lymphocytes were uniformly higher in pleural effusions than in peripheral blood; however, lower percentages of B lymphocytes and cells positive for the

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2

Winther, Birgit, Donald J. Innes, John Bratsch, and Frederick G. Hayden. "Lymphocyte Subsets in the Nasal Mucosa and Peripheral Blood during Experimental Rhinovirus Infection." American Journal of Rhinology 6, no. 4 (1992): 149–56. http://dx.doi.org/10.2500/105065892781874621.

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The local cellular response during rhinovirus infection was studied with immunohistochemical staining of lymphocyte subpopulations in the lamina propria of the nasal mucosa (inferior turbinate) in 25 biopsies from volunteers with experimental rhinovirus colds and compared with biopsies from healthy volunteers. Biopsies from rhinovirus infected volunteers, taken either in the early phase of the infection (days 3 and 5) or during convalescence (day 14) were evaluated in a semiquantitative fashion for degree of infiltration. Lymphocyte subpopulations also were counted on coded specimens. During e

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Kodintseva, E. A., and A. А. Akleyev. "Prospects and Methods for Studying the Proliferative Capacity of the Human Peripheral Blood Lymphocyte Subpopulations in Radiation Medicine." MEDICAL RADIOLOGY AND RADIATION SAFETY 69, no. 5 (2024): 66–74. http://dx.doi.org/10.33266/1024-6177-2024-69-5-66-74.

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Introduction 1. Proliferation of peripheral blood lymphocytes as an integrative indicator of the functional activity of ICS in normal and pathological conditions. 2. Features of proliferative activity of peripheral blood lymphocytes under the action of AI. 3. Methodological approaches to the quantitative determination of proliferating cells in human peripheral blood lymphocyte subpopulations. Conclusion

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Concha, Carlos, and Olof Holmbebg. "Ability of bovine mammary macrophages to enhance proliferation of autologous blood and mammary secretion lymphocytes." Journal of Dairy Research 57, no. 1 (1990): 7–16. http://dx.doi.org/10.1017/s0022029900026558.

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SummaryCells were obtained by centrifuging the mammary secretion of healthy udders of 19 cows during the dry-period and during mid-lactation. The suspended cells were incubated in plastic wells. Those adhered cells classified as mammary macrophages were incubated with pokeweed mitogen (PWM). Autologous peripheral blood lymphocytes were added to wells containing untreated macrophage cultures or cultures pretreated with PWM. In seven cows autologous dry-period mammary lymphocytes were added instead of blood lymphocytes. The macrophages + lymphocyte cultures were subjected to the lymphocyte stimu

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Arsenović-Ranin, Nevena, Duško Kosec, Mirjana Nacka-Aleksić, et al. "Ovarian hormone level alterations during rat post-reproductive life-span influence CD8 + T-cell homeostasis." Experimental Biology and Medicine 240, no. 10 (2015): 1319–32. http://dx.doi.org/10.1177/1535370215570817.

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The study examined the putative role of ovarian hormones in shaping of rat peripheral T-cell compartment during post-reproductive period. In 20-month-old rats ovariectomized (Ox) at the very end of reproductive period, thymic output, cellularity and composition of major TCRαβ + peripheral blood lymphocyte and splenocyte subsets were analyzed. Ovariectomy led to the enlargement of CD8 + peripheral blood lymphocyte and splenocyte subpopulations. This reflected: (i) a more efficient thymic generation of CD8 + cells as indicated by increased number of CD4+CD8 + double positive and the most mature

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Soloviev, V. Yu, and E. A. Gudkov. "Application of Hematological Test Results for Severity Assessment of Acute Radiation Injury on Early Stages." MEDICAL RADIOLOGY AND RADIATION SAFETY 67, no. 3 (2022): 26–29. http://dx.doi.org/10.33266/1024-6177-2022-67-3-26-29.

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Purpose: Investigation of the predictive value of information on the concentrations of neutrophils and lymphocytes in the peripheral blood of victims of radiation accidents in the first days (2 to 9) after exposure to predict the severity of acute radiation injury. Material and methods: Data on the post-radiation dynamics of the concentrations of lymphocytes and neutrophils in the peripheral blood of victims of the accident at the Chernobyl nuclear power plant in 1986 from the database on acute radiation injuries to humans of the A.I. Burnasyan Federal Medical Biophysical Center was used. Corr

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7

Folks, T., J. Kelly, S. Benn, et al. "Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV." Journal of Immunology 136, no. 11 (1986): 4049–53. http://dx.doi.org/10.4049/jimmunol.136.11.4049.

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Abstract Normal human peripheral blood lymphocytes were tested for their susceptibility to infection with retroviruses isolated from patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Of 10 normal individuals tested, lymphocytes from all subjects became infected and produced virus as detected by assay for Mg+2-dependent reverse transcriptase. Lymphocytes from different individuals were demonstrated to be either high or low producers of reverse transcriptase after infection. The kinetics of virus production were similar in cells from both high- and low-producin

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Seabrook, Tim J., Wayne R. Hein, Lisbeth Dudler, and Alan J. Young. "Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool." Blood 96, no. 3 (2000): 1180–83. http://dx.doi.org/10.1182/blood.v96.3.1180.

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Abstract The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved. Here we show that neonatal splenectomy in sheep does not abrogate the development of a large, nonrecirculating pool of lymphocytes and that it has no effect on the acquisition of a normal blood lymphocyte profile. Splenectomy did, however, result in a significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating lymphocytes in lymph nodes. Furthermore, nonrecirculating

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Seabrook, Tim J., Wayne R. Hein, Lisbeth Dudler, and Alan J. Young. "Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool." Blood 96, no. 3 (2000): 1180–83. http://dx.doi.org/10.1182/blood.v96.3.1180.015k24_1180_1183.

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The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved. Here we show that neonatal splenectomy in sheep does not abrogate the development of a large, nonrecirculating pool of lymphocytes and that it has no effect on the acquisition of a normal blood lymphocyte profile. Splenectomy did, however, result in a significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating lymphocytes in lymph nodes. Furthermore, nonrecirculating periphera

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Lewis, Sharon L., Susan G. Kutvirt, Christa L. Cooper, Peter N. Bonner, and Clifford J. Holmes. "Characteristics of Peripheral and Peritoneal Lymphocytes from Continuous Ambulatory Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 13, no. 2_suppl (1993): 273–77. http://dx.doi.org/10.1177/089686089301302s69.

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The role of peritoneal lymphocytes in host immunity for continuous ambulatory peritoneal dialysis (CAPD) patients Is just beginning to be understood. CAPD therapy Increases the proportion of peritoneal lymphocytes, most of which demonstrate signs of activation. There are decreased peritoneal T cells and increased peritoneal B cells as compared to the patients’ peripheral blood. When studies examine Immunophenotypes of peripheral and peritoneallymphocytes over time, no significant changes are found. Although changes in peritoneal lymphocyte subsets occur during peritonitis episodes, there are n

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11

Appel, Max J. G., Susan Pearce-Kelling, and Brian A. Summers. "Dog Lymphocyte Cultures Facilitate the Isolation and Growth of Virulent Canine Distemper Virus." Journal of Veterinary Diagnostic Investigation 4, no. 3 (1992): 258–63. http://dx.doi.org/10.1177/104063879200400306.

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Optimal conditions for the isolation and growth of virulent canine distemper virus (CDV) in canine thymic and peripheral blood lymphocyte cultures were determined. Peak virus titers were seen from 3 to 6 days postinoculation of lymphocytes and depended on the multiplicity of infection. Dog lymphocytes were at least as susceptible as canine macrophages to infection with virulent CDV. Virus replication in lymphocytes resulted in higher virus titers than in dog lung macrophages. Peripheral blood lymphocytes (PBL) from CDV-immune dogs were as susceptible to CDV as were PBL from susceptible dogs.

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Guo, Jia, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, and Sara A. Michie. "LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels." Biomolecules 13, no. 8 (2023): 1194. http://dx.doi.org/10.3390/biom13081194.

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Lymphocyte function-associated antigen-1 (LFA-1) and its endothelial ligand intercellular adhesion molecule-1 (ICAM-1) are important for the migration of lymphocytes from blood vessels into lymph nodes. However, it is largely unknown whether these molecules mediate the homeostatic migration of lymphocytes from peripheral tissues into lymph nodes through lymphatic vessels. In this study, we find that, in naive mice, ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. In in vivo lymphocyte migration assays, memory CD4+ T cells migra

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Vrndic, Olgica B., Predrag M. Djurdjevic, Danijela D. Jovanovic, et al. "Blood cells in thyroid cancer patients: a possible influence of apoptosis." Open Medicine 11, no. 1 (2016): 87–92. http://dx.doi.org/10.1515/med-2016-0017.

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AbstractThe side effects of radioactive iodine (131-I) treatment of differentiated thyroid cancer (DTC) patients include reduction of peripheral blood cell counts. The aim of this study was to analyze some potential changes in blood cell counts of DTC patients after 131-I therapy, especially CD3-positive, CD19-positive, and CD56-positive peripheral blood lymphocytes (PBL), as well as the possible role of apoptosis in selected lymphocyte populations. The study group included 24 thyroid cancer patients and 24 control subjects. Peripheral blood samples from patients and controls were analyzed usi

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Gette, I. F., and I. G. Danilova. "State of hyperglycemic and immunomodulator-treated peripheral blood lymphocytes." Russian Journal of Immunology 23, no. 3 (2020): 329–34. http://dx.doi.org/10.46235/1028-7221-269-soh.

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A level of peripheral blood lymphocytes, their functional activity and particularly produced range of secreted cytokines underlie severity of autoimmune process in diabetes mellitus (DM) against islet β-cells and other body cells. Because cytokine production is coordinated by macrophages and may also depend on accessibility lymphocyte nucleic acids, we aimed at examining level of nucleic acids in blood lymphocytes as well as cytokine production in rats with alloxan-induced diabetes treated with immunomodulatory 3-aminophthalhydrazide (3-APH). Type 1 DM was modeled in male WISTAR rats by intrap

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Klein, Ami, Michael Lishner, Barbara Bruser, John E. Curtis, Dominick J. Amato, and Aaron Malkin. "Cortisol catabolism by lymphocytes of patients with chronic lymphocytic leukemia." Biochemistry and Cell Biology 68, no. 4 (1990): 810–13. http://dx.doi.org/10.1139/o90-118.

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A low rate of catabolism of cortisol by lymphocytes correlates with high sensitivity of the cells to the steroid and causes them to die at a greater rate than control samples. Since lymphocytes of patients with chronic lymphocytic leukemia respond to treatment with glucocorticosteroids and are cortisol sensitive, we attempted to see whether their capability to catabolize cortisol differs from that of normal lymphocytes. No difference was found between the two groups of cells with regard to the pattern of cortisol metabolites. However, the lymphocytes of the chronic lymphocytic leukemia groups

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Ryu, Hoon, Chang Duk Jun, Bok Soo Lee, Byung Min Choi, Hyung Min Kim, and Hun-Taeg Chung. "Effect of Qigong Training on Proportions of T Lymphocyte Subsets in Human Peripheral Blood." American Journal of Chinese Medicine 23, no. 01 (1995): 27–36. http://dx.doi.org/10.1142/s0192415x95000055.

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The effect of Qigong training on proportions of T lymphocyte subsets was investigated in human peripheral blood. We observed that the ratio of CD4+/CD8+ T lymphocytes was increased as much as 50% in a trainee group who practiced Qigong training more than 5 months compared to a normal healthy group who did not practice. The absolute number of CD4+ T lymphocytes was also elevated in trainee group with 100 cells/mm 3 more than in normal healthy group. The positive correlation between the ratio of CD4+/CD8+ T lymphocytes and the ratio of CD4+45RA-/CD4+ CD45RA+ T lymphocytes was shown in the traine

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Caruntu, Ana, Liliana Moraru, Mihaela Surcel, et al. "Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma." Healthcare 10, no. 2 (2022): 342. http://dx.doi.org/10.3390/healthcare10020342.

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Background: Oral squamous cell carcinoma (OSCC) is a common cancer with high morbidity and mortality. Alterations of antitumor immune responses are involved in the development of this malignancy, and investigation of immune changes in the peripheral blood of OSCC patients has aroused the interest of researchers. Methods: In our study, we assessed the proportions of CD3+ total T lymphocytes, CD3+CD4+ helper T lymphocytes, CD3+CD8+ suppressor/cytotoxic T lymphocytes, CD3−CD19+ total B lymphocytes, and CD3−CD16+CD56+ NK cells in the peripheral blood of OSCC patients. Results: The data obtained bo

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Zhang, Lulu, Tinghua Feng, and Hui Liu. "Lymphocyte Transformation Test Based on Lymphocyte Changes Observed by a Hematology Analyzer before and after Phytohemagglutinin Stimulation." Disease Markers 2022 (November 7, 2022): 1–7. http://dx.doi.org/10.1155/2022/5967429.

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Objective. The lymphocyte transformation test is a classical test for the detection of cellular immune function and is based on subjective judgment. In this study, we have established an objective novel lymphocyte transformation test using the hematology analyzer to observe lymphocyte transformation. Methods. Whole blood cells were cultured using a whole blood method with a lymphocyte culture medium; phytohemagglutinin was used to stimulate the experimental samples, and control was set up at the same time. After the whole blood cells were cultured, the number of lymphocytes in the two groups w

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Streeter, P. R., B. T. Rouse, and E. C. Butcher. "Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes." Journal of Cell Biology 107, no. 5 (1988): 1853–62. http://dx.doi.org/10.1083/jcb.107.5.1853.

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The tissue localization or "homing" of circulating lymphocytes is directed in part by specialized vessels that define sites of lymphocyte exit from the blood. In peripheral lymph nodes, mucosal lymphoid tissues (Peyer's patches and appendix), and sites of chronic inflammation, for example, lymphocytes leave the blood by adhering to and migrating between those endothelial cells lining postcapillary high endothelial venules (HEV). Functional analyses of lymphocyte interactions with HEV have shown the lymphocytes can discriminate between HEV in different tissues, indicating that HEV express tissu

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Chim, C. S., R. Pang, and R. Liang. "Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia." Journal of Clinical Pathology 61, no. 11 (2008): 1214–19. http://dx.doi.org/10.1136/jcp.2008.060152.

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Background:Wnt signalling has recently been implicated in the pathogenesis of cancer.Methods:This study investigated the activity of Wnt signalling in peripheral blood chronic lymphocytic leukaemia (CLL) lymphocytes, and the methylation status of seven soluble Wnt antagonist genes, including WIF1, DKK3, APC, SFRP1, SFRP2, SFRP4 and SFRP5, by using methylation-specific PCR in the peripheral blood CLL lymphocytes and bone marrow samples of patients with CLL at diagnosis.Results:In the peripheral blood CLL lymphocytes, constitutive activation of Wnt signalling was detected, associated with hyperm

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Eke, Dilek, and Ayla Çelik. "In vitro Effects of Thimerosal and Its Metabolites on Cell Proliferation Kinetics and micronuclei frequency of Stimulated Human Lymphocytes (-S9/+S9)." Euroasia Journal of Mathematics, Engineering, Natural & Medical Science 10, no. 28 (2023): 13–22. https://doi.org/10.5281/zenodo.8189561.

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Thimerosal is an ethylmercury-containing preservative in vaccines and biomedical preparations. Little is known about the genotoxicity reactions of thimerosal in human peripheral blood lymphocytes in vitro. In the study, short-term thimerosal toxicity was investigated in cultured human peripheral blood lymphocytes under conditions with and without S9 fraction. Cytokinesis-Block Micronucleus Test is<strong> </strong>a useful technique for the assessment of genotoxicity. Cultured human peripheral blood lymphocyte cells were incubated with 0.2µg/ml-0.6µg/ml concentrations of thimerosal

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Lewis, Sharon L., Susan G. Kutvirt, Larry C. Seamer, and Clifford J. Holmes. "Calcium Metabolism in Blood and Peritoneal L Ymphocytes from Continuous Ambulatory Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 17, no. 3 (1997): 287–94. http://dx.doi.org/10.1177/089686089701700313.

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Objective Cellular immune function in peritoneal dialysis patients has been shown to be depressed, but the mechanism of this immunosuppression has not been ascertained. Because calcium is an important mediator of lymphocyte activation, this study was designed to investigate if there was an alteration of calcium metabolism in the lymphocytes of continuous ambulatory peritoneal dialysis (CAPD) patients. Design Sixteen CAPD patients were studied at the initiation of CAPD and after two months of treatment. Twenty-three normal controls were also enrolled in the study. Cytoplasmic calcium changes we

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Guclu, Mustafa, and A. Faruq Agan. "Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume." Euroasian Journal of Hepato-Gastroenterology 7, no. 1 (2017): 11–16. http://dx.doi.org/10.5005/jp-journals-10018-1204.

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ABSTRACT Aim To determine the correlation of Helicobacter pylori infection with peripheral blood neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). Materials and methods The NLR, MPV, platelets, leukocytes, neutrophils, and lymphocytes were calculated and the differences between groups were investigated. Results A total of 199 patients were included in the study. Neutrophil/lymphocyte ratio was statistically lower in H. pylori-positive patients than in H. pylori-negative patients (1.94 ± 0.79 vs 2.67 ± 2.35 respectively, p = 0.04). There was no significant difference between H.

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Kanakry, Christopher G., Allan D. Hess, Christopher D. Gocke, et al. "Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells." Blood 117, no. 2 (2011): 608–17. http://dx.doi.org/10.1182/blood-2010-04-277939.

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AbstractFew published studies characterize early lymphocyte recovery after intensive chemotherapy for acute myelogenous leukemia (AML). To test the hypothesis that lymphocyte recovery mirrors ontogeny, we characterized early lymphocyte recovery in 20 consecutive patients undergoing induction timed sequential chemotherapy for newly diagnosed AML. Recovering T lymphocytes were predominantly CD4+ and included a greatly expanded population of CD3+CD4+CD25+Foxp3+ T cells. Recovering CD3+CD4+CD25+Foxp3+ T cells were phenotypically activated regulatory T cells and showed suppressive activity on cytok

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Skerget, Matevz, Barbara Skopec, and Samo Zver. "Repopulation of Lymphocytes and Natural Killer Cells on Day 15 Following First Autologous Stem Cell Transplantation in Myeloma Patients Correlates with the Number of Reinfused Lymphocytes and Natural Killer T Cells in the Autologous Graft." Blood 128, no. 22 (2016): 5820. http://dx.doi.org/10.1182/blood.v128.22.5820.5820.

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Abstract Introduction Autologous hematopoietic stem cell transplantation (aHSCT) is still considered standard of care for eligible myeloma patients following induction treatment. Beside the effect of a high dose melphalan, several studies proposed a beneficial effect of immune graft versus myeloma effect following aHSCT. The higher number of lymphocytes and natural killer (NK) cells on day 15 after aHSCT correlated with a better longterm outcome. We have previously published the data on the influence of different mobilization regimens on the number of collected lymphocytes and NK cells and the

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Stahnke, Karsten, Simone Fulda, Claudia Friesen, Gudrun Strauß, and Klaus-Michael Debatin. "Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy." Blood 98, no. 10 (2001): 3066–73. http://dx.doi.org/10.1182/blood.v98.10.3066.

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Abstract In addition to myelosuppression, anticancer drugs cause rapid and persistent depletion of lymphocytes, possibly by direct apoptosis induction in mature T and B cells. Induction of apoptosis regulators was analyzed in peripheral blood lymphocytes from pediatric patients undergoing first-cycle chemotherapy for solid tumors. In vivo chemotherapy induced a significant increase in lymphocyte apoptosis ex vivo. The activation of initiator caspase-8 and effector caspase-3 and the cleavage of caspase substrates was detected 12 to 48 hours after the onset of therapy. Caspase inhibition by Z-VA

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Matsushima, K., A. Procopio, H. Abe, G. Scala, J. R. Ortaldo, and J. J. Oppenheim. "Production of interleukin 1 activity by normal human peripheral blood B lymphocytes." Journal of Immunology 135, no. 2 (1985): 1132–36. http://dx.doi.org/10.4049/jimmunol.135.2.1132.

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Abstract Interleukin 1 (IL 1) production by normal human B lymphocytes was investigated. Normal human peripheral blood B lymphocytes were purified by sequential separation with the use of Ficoll-Hypaque gradient centrifugation, sheep red blood cell rosette formation, Percoll gradients, and treatment with monoclonal antibodies (anti-Leu-M1, B73.1, and T101) and complement. Both purified large B lymphocytes (BL) and small B lymphocytes (BS) produced IL 1-like (thymocyte co-mitogenic and fibroblast mitogenic) activities in response to lipopolysaccharide. Maximal production of IL 1 activity by bot

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Dejanović, Hristina, and Danijela Jovanović. "Concentration of cytokines (IL-4, IL-12, IFNg) in the blood plasma and its association with lymphocyte apoptosis in patients suffering from chronic lymphocytic leukemia." Srpski medicinski casopis Lekarske komore 4, no. 4 (2023): 368–72. http://dx.doi.org/10.5937/smclk4-47931.

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Introduction: Chronic lymphocytic leukemia (CLL) is a malignant disease of hematopoietic tissue and is the most common leukemia in adults. For years, the dominant view was that in the pathogenesis of chronic lymphocytic leukemia, the basic mechanism of the origin and progression of the disease is disruption in apoptosis and prolonged survival of malignant lymphocytes. Aim: The aim of our study is to determine the association between the percentage of apoptotic lymphocytes in the peripheral blood of patients suffering from chronic lymphocytic leukemia and the concentration of antiapoptotic cyto

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Aringazina, Raisa, Nazgul Seitmaganbetova, Aigul Mussina, et al. "Peripheral blood lymphocytes apoptosis role in rheumatoid arthritis progressing." Journal of Clinical Medicine of Kazakhstan 20, no. 4 (2023): 4–9. http://dx.doi.org/10.23950/jcmk/13527.

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Rheumatoid arthritis (RA) is an autoimmune, chronic, and genetically linked inflammatory lesion of joint tissues that is accompanied by extra-articular systemic pathologies. The disease progression leads to joints immobilization, and eventually, the patient's disability occurs approximately ten years from the first clinical manifestation. RA pathogenesis involves various mechanisms: specific joint-related damage, nonspecific adaptive, and vessel-related pathological changes. Our research aimed to study the role of peripheral blood lymphocyte apoptosis in RA pathogenesis. We have analyzed resea

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Dung Do, Thi Mai, Phan Hai An Ha, Van Dong Le, and Quang Thuan Huynh. "A survey on lymphocyte T CD3, CD4 and CD8 in peripheral blood of kidney transplant recipients using mycophenolic acid." Journal of Nephropathology 10, no. 4 (2021): e41-e41. http://dx.doi.org/10.34172/jnp.2021.41.

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Introduction: Immunological monitoring could indirectly measure the suppressive effects of the drugs and provide early guidance on necessary preventive interventions in transplant recipients. Objectives: Our goal was to determine whether mycophenolic acid (MPA) modulates peripheral blood lymphocyte T in kidney transplant recipients. Patients and Methods: We assessed T lymphocytes CD3, CD4 and CD8 in peripheral blood in 30 donors and 35 recipients one day before and 10 days after transplantation using Becton Dickinson’s direct immune fluorescent light. Results: Comparisons showed that the numbe

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Bolhuis, Reinder L. H., Hennie R. Hoogenboom, and Jan Willem Gratama. "Targeting of peripheral blood T lymphocytes." Springer Seminars in Immunopathology 18, no. 2 (1996): 211–26. http://dx.doi.org/10.1007/bf00820667.

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Davis, P., H. J. Freeman, and A. B. R. Thomson. "Celiac Sprue and Abdominal Lymphoma: Studies on the Cell-Mediated Immune Response of Peripheral Blood Lymphocytes." Canadian Journal of Gastroenterology 2, no. 1 (1988): 12–14. http://dx.doi.org/10.1155/1988/838210.

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The development of primary abdominal lymphoma is a recognized complication of gluten-sensitive enteropathy (GSE). ln five patients with GSE plus lymphoma, the distribution and function of peripheral blood lymphocytes were determined and compared with 13 patients with GSE without lymphoma and with 28 normal control subjects. The percentage of T cells was lower in patients with GSE and GSE with lymphoma than in controls, whereas patients with GSE plus lymphoma had a significantly increased number of peripheral blood B lymphocytes when compared with GSE patients or controls. There was no differen

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Al-Samaraee, Israa F. J., Saba F. Salih, and Y'arub Idrees Khattab. "The role of Lymphocytes Apoptosis in Grave's Disease Patients." Journal of the Faculty of Medicine Baghdad 52, no. 4 (2011): 453–58. http://dx.doi.org/10.32007/jfacmedbagdad.524956.

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Background: Apoptosis is a physiological type of cell death; it is active, well-controlled genetic program of cell death that does not produce inflammatory process. It is involved in cell turnover in healthy adult tissues and it is responsible for focal elimination of unwanted cells during normal embryonic development, organ homeostasis, immune regulation and defense without causing stress to the neighboring cells.Method: This study was carried on 30 Grave's disease female patients with a mean age of (29.8 ± 8.3) years. The study parameters were considered as: before and after treatment; patie

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Chiba, Kenji, Yoshiki Yanagawa, Yumi Masubuchi, et al. "FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing." Journal of Immunology 160, no. 10 (1998): 5037–44. http://dx.doi.org/10.4049/jimmunol.160.10.5037.

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Abstract FTY720, given i.v. or orally at 0.03 mg/kg or more, significantly prolonged skin allograft survival in a dose-dependent manner and showed more potent immunosuppressive activity than cyclosporin A (CsA) or tacrolimus (FK506) in MHC-incompatible rat strains of WKAH donors and F344 recipients. However, unlike CsA or FK506, FTY720 up to 1000 nM did not affect IL-2 production in allogeneic MLC. Within 3 to 24 h after a single oral administration of FTY720 at 0.1 to 1 mg/kg, the number of lymphocytes in the rats was markedly decreased in the peripheral blood and thoracic duct lymph and part

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McKay, Paul F., Dan H. Barouch, Jörn E. Schmitz, et al. "Global Dysfunction of CD4 T-Lymphocyte Cytokine Expression in Simian-Human Immunodeficiency Virus/SIV-Infected Monkeys Is Prevented by Vaccination." Journal of Virology 77, no. 8 (2003): 4695–702. http://dx.doi.org/10.1128/jvi.77.8.4695-4702.2003.

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ABSTRACT Human immunodeficiency virus type 1 infection results in a dysfunction of CD4+ T lymphocytes. The intracellular events contributing to that CD4+ T-lymphocyte dysfunction remain incompletely elucidated, and it is unclear whether aspects of that dysfunction can be prevented. The present studies were pursued in a rhesus monkey model of AIDS to explore these issues. Loss of the capacity of peripheral blood CD4+ T lymphocytes to express cytokines was first detected in simian immunodeficiency virus-infected monkeys during the peak of viral replication during primary infection and persisted

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Han, Jingqi, Linglin Zhao, Jianying Wu, et al. "Role of CD4+T, CD8+T Cells, and CD4+T/CD8+T Cell Ratio in Gastric Cancer and Its Clinical Significance." Applied Bionics and Biomechanics 2022 (April 30, 2022): 1–11. http://dx.doi.org/10.1155/2022/1094607.

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Objective. To study the expression and clinical importance of CD4+T, CD8+T cells, and CD4+T/CD8+T cell percentage in gastric cancer (GC) patients. Methods. The blood count of CD4+T and CD8+T lymphocytes was ascertained via flow cytometry before surgery in 93 GC patients undergoing gastrectomy. The CD4+T, CD8+T, and Foxp3+T lymphocytes in cancerous and normal adjacent tissues and the presence of PD-L1 in cancerous tissues were detected via immunohistochemistry. The link between the permeation of CD4+T, CD8+T lymphocytes in venous blood, and cancer and normal adjacent tissues was analyzed. Resul

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Muto, Satoshi, Hayato Mine, Hironori Takagi, et al. "Can immunologically hot lung cancer be distinguished from cold tumor by peripheral blood?" Journal of Clinical Oncology 38, no. 5_suppl (2020): 48. http://dx.doi.org/10.1200/jco.2020.38.5_suppl.48.

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48 Background: Depending on the number of tumor infiltrating lymphocytes, immunological cold to hot conditions vary. There are several clinical trials of administering immune checkpoint inhibitors as perioperative adjuvant therapy. Immune checkpoint inhibitors are generally effective in immunologically hot conditions. However, biopsy specimens are not enough to determine the amount of tumor infiltrating lymphocytes. Therefore, we focused on effector T lymphocytes in peripheral blood, and tried to understand the tumor microenvironment by looking at peripheral blood. Methods: Twenty-four patient

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Howard, Martin R., and Michael M. Reid. "Immunoglobulin crystals in peripheral blood lymphocytes in chronic lymphocytic leukaemia." British Journal of Haematology 121, no. 3 (2003): 381. http://dx.doi.org/10.1046/j.1365-2141.2003.04219.x.

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Bouchama, A., K. al Hussein, C. Adra, M. Rezeig, E. al Shail, and S. al Sedairy. "Distribution of peripheral blood leukocytes in acute heatstroke." Journal of Applied Physiology 73, no. 2 (1992): 405–9. http://dx.doi.org/10.1152/jappl.1992.73.2.405.

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We examined 11 heatstroke patients (mean rectal temperature 41.4 +/- 0.3 degrees C) and 40 healthy subjects to determine the effects of hyperthermia on peripheral blood leukocyte distribution. Precooling samples were taken on admission. Whole blood was incubated with conjugated monoclonal antibodies, and erythrocytes were eliminated by FACS lysing solution. Lymphocyte subsets were detected by specific mouse monoclonal antibodies: Leu-4/CD3+ (T-cells), Leu-3a/CD4+ (T-helper cells), Leu-2a/CD8+ (T-suppressor-cytotoxic cells), Leu-11/19/CD16+/CD56+ (natural killer cells), and Leu-12/CD19+ (B-cell

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Gambacorti-Passerini, Carlo, Raffaele Marolda, Gabriella Tona, et al. "Infusion of Autologous Alloactivated Lymphocytes in Melanoma Patients: Toxicity and Immunologic Monitoring." Tumori Journal 72, no. 4 (1986): 383–88. http://dx.doi.org/10.1177/030089168607200407.

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Previous work has shown that infusion of autologous helper-enriched, alloactivated lymphocytes in melanoma patients may induce, in addition to other mild signs of toxicity, a transient but sharp elevation of blood pressure. To avoid such a disturbing symptom, the in vitro protocol of peripheral blood lymphocyte activation has been modified. In the present study we show that such a modification has led to a lower toxicity of autologous lymphocyte infusion in 4 melanoma patients; in particular, hypertension was no longer observed. In addition, an immunologic monitoring was carried out in these p

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Berber, Ilhami, Ozlem Cagasar, Ahmet Sarıcı, et al. "SIMPLE PERIPHERAL BLOOD SMEAR FINDINGS OF COVID-19 PATIENTS PROVIDE INFORMATION ABOUT THE SEVERITY OF THE DISEASE AND THE DURATION OF HOSPITAL STAY." Mediterranean Journal of Hematology and Infectious Diseases 13, no. 1 (2020): e2021009. http://dx.doi.org/10.4084/mjhid.2021.009.

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Backround Data about the morphological changes of Covid-19 infection in peripheral blood smear are limited and association with clinical severity of the disease are not known yet. We aimed to examine the characteristics of the cells detected in the pathological rate and / or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in Covid-19 patients. Methods Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with Covid-19 by PCR was evaluated at diagnosis. P

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Maslak, G. S., G. P. Chernenko, V. M. Baibakov, et al. "Changes in Glycanic Determinants of Lymphocytes Membranes in Peripheral Blood in Patients with B-Cell Chronic Lymphocytic Leukemia under Antitumor Therapy." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 6 (2021): 141–47. http://dx.doi.org/10.26693/jmbs06.06.141.

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The purpose of the study was to study the nature of changes in the exposure of surface glycans of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy. Materials and methods. We studied the features of exposure of surface glycotopes of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy using a set of seven lectins labeled with FITC and monoclonal antibodies to Tn-antigen- FITC for the detection of Tn antigen and CD43 exposure on blood lymphocytes. Cytostatic t

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Lage, Luís Alberto de Pádua Covas, Igor Cerejo Almeida, Cadiele Oliana Reichert, et al. "Does Peripheral Blood Mirror Immune Tumor Microenvironment? Flow Cytometry Quantification of Peripheral Blood Lymphocyte Subpopulations and Outcomes in Patients with Diffuse Large B-Cell Lymphoma." Blood 144, Supplement 1 (2024): 6259. https://doi.org/10.1182/blood-2024-208293.

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Introduction: Diffuse large B-cell lymphoma (DLBCL) presents clinical, biological, and prognostic heterogeneity. The composition of the tumor microenvironment (TME), including cytotoxic CD8+T-lymphocytes, NK cells, and macrophages, strongly contributes for its biological diversity, being able to predict treatment response and determine prognosis. DLBCL with TME enriched in CD8+T-lymphocytes and NK cells demonstrate increased OS compared to those with TME enriched in histiocytes. Data from patients with solid tumors have established strong associations between absolute quantification of lymphoc

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Slepicheva, N. R., O. I. Urazova, V. V. Novitsky, and A. P. Pomogayeva. "Cytotoxic activity of peripheral blood lymphocytes in children with infectious mononucleosis." Bulletin of Siberian Medicine 8, no. 4 (2009): 64–69. http://dx.doi.org/10.20538/1682-0363-2009-4-64-69.

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Twenty children aged 3—6 years with Epstein—Barr-virus-induced infectious mononucleosis (IM) were examined. The present study is aimed at investigating the functional activity of cytotoxic lymphocytes in children with IM during clinical and hematological manifestation of the disease and early reconvalescence phase. For analyzing the subpopulation composition of peripheral blood lymphocytes in children with IM the CD-receptors on cell surfaces (CD8, CD16) were defined; for estimating apoptosis the amount of CD95-, CD95L- and annexin V-positive lymph cells (immunofluorescence method) was assesse

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Lanier, L. L., A. M. Le, C. I. Civin, M. R. Loken, and J. H. Phillips. "The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." Journal of Immunology 136, no. 12 (1986): 4480–86. http://dx.doi.org/10.4049/jimmunol.136.12.4480.

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Abstract We examined the antigenic and functional characteristics of human peripheral blood lymphocytes that differentially express the CD16 (Leu-11) and Leu-19 (NKH-1) antigens. Leu-19 is a approximately 220,000 daltons protein expressed on approximately 15% of freshly isolated peripheral blood lymphocytes. Within the Leu-19+ subset, three distinct populations were identified: CD3-,CD16+,Leu-19+ cells; CD3+,CD16-,Leu-19+ cells; and CD3-,CD16-,Leu-19bright+ cells. Both the CD3+,CD16-,Leu-19+ and CD3-,CD16+,Leu-19+ populations mediated non-major histocompatibility complex (MHC)-restricted cytot

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Yakovlev, P. G., and D. A. Klyushin. "Lymphocytes in peripheral blood as differential indicator of the stage of pathological condition in urooncological patients." Likarska sprava, no. 8 (December 30, 2017): 83–89. http://dx.doi.org/10.31640/ls-2017-8-11.

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Absolute lymphocyte count and neutrophil/lymphocyte ratio are the indicators of systemic inflammatory response involved in pathogenesis and progression of cancer. We demonstrate that absolute lymphocyte count and share of lymphocytes in peripheral blood truly differentiate between different states of the disease: urological cancer, healthy individual, benign urological condition and urological cancer after radical treatment. Considering involvement of lymphocytes in systemic inflammatory response and pathogenesis of cancer medical interventions targeting lymphocyte may yield therapeutic benefi

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Kadushkin, A. G., A. D. Tahanovich, L. V. Movchan, M. M. Zafranskaya, and T. V. Shman. "Impact of azithromycin on the migration of peripheral blood T lymphocytes from patients with chronic obstructive pulmonary disease to RANTES and IP-10." Proceedings of the National Academy of Sciences of Belarus, Medical series 20, no. 3 (2023): 191–204. http://dx.doi.org/10.29235/1814-6023-2023-20-3-191-204.

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The inflammatory process specific for chronic obstructive pulmonary disease (COPD) is accompanied by T lymphocyte migration from peripheral blood to the respiratory tract. Suppression of T cell chemotaxis by drugs may attenuate the inflammatory response in patients with COPD.The aim of this study was to determine the ability of azithromycin in combination with glucocorticoids to affect the migration of blood T cells in patients with COPD.The percentage of T lymphocytes expressing chemokine receptors CCR5, CCR6, CCR7, CXCR3, CXCR4, CXCR6 was analyzed by flow cytometry in the peripheral blood of

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Li-Chang, Hector Hugo, Naziheh Assarzadegan, David Messenger, Andrea Grin, Christopher Howlett, and Richard Kirsch. "Correlation of peripheral blood lymphocyte counts with outcome and histopathologic features of lymphocytic inflammation in patients with stage II colorectal carcinoma." Journal of Clinical Oncology 32, no. 3_suppl (2014): 475. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.475.

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475 Background: The prognostic importance of the local antitumor immune response in colorectal carcinoma (CRC) is well established. Recent studies suggest that systemic antitumor immunity may also impact on survival. This study aimed to determine the relationship between peripheral blood lymphocyte counts (PBLCs), reactive features in regional lymph nodes, local tumoral/peri-tumoral lymphocytic inflammation and survival in stage II CRC. Methods: Resection specimens from 185 patients with stage II CRC were assessed for peri-tumoral lymphocytic inflammation, tumor-infiltrating lymphocytes, lymph

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Keller, Margaret A., Judy Faust, Lawrence J. Rolewic, and Diana D. Stewart. "T Cell Subsets in Human Colostrum." Journal of Pediatric Gastroenterology and Nutrition 5, no. 3 (1986): 439–43. http://dx.doi.org/10.1002/j.1536-4801.1986.tb09101.x.

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Summary: Lymphocytes from 10 paired colostrum and peripheral blood specimens were examined to determine if the colostral T cell population differs from the peripheral blood T cell population in subset distribution. The percentages of lymphocytes staining with OKT3, OKT4, and OKT8 murine monoclonal antibody were determined. Lymphocytes from colostrum were 74.7 ± 2.5% OKT3+, 50.6 ± 2.3% OKT4+, 24.0 ± 1.7% OKT8+, whereas peripheral blood lymphocytes were 78.7 ± 1.9% OKT3+, 48.4 ± 1.4% OKT4+, and 29.8 ± 1.6% OKT8+. The percentage of colostrum lymphocytes positive for OKT3 was significantly althoug

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Tanaka, Hirotoshi, Yoichi Ichikawa, Hideto Akama, and Mitsuo Homma. "In vivo responsiveness to glucocorticoid correlated with glucocorticoid receptor content in peripheral blood leukocytes in normal humans." Acta Endocrinologica 121, no. 4 (1989): 470–76. http://dx.doi.org/10.1530/acta.0.1210470.

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Abstract. Dexamethasone loading tests (0.1 mg dexamethasone/kg, iv) were performed in 18 normal males to evaluate the individual responsiveness to glucocorticoid. There were inter-individual differences in increase in peripheral blood polymorphonuclear leukocyte count, decrease in peripheral blood lymphocyte count, and increase in plasma free fatty acids levels after dexamethasone injection. In addition, there was a significant correlation between the maximum increase in polymorphonuclear leukocytes and the maximum decrease in lymphocytes (r = 0.7514, p < 0.0003). Simultaneous measurements

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