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Relevant bibliographies by topics / Macrophages/drug effects

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Academic literature on the topic 'Macrophages/drug effects'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Macrophages/drug effects"

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Fischer, Carrie D., Jennifer K. Beatty, Stephanie C. Duquette, Douglas W. Morck, Merlyn J. Lucas, and André G. Buret. "Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis." Antimicrobial Agents and Chemotherapy 57, no. 3 (2013): 1385–93. http://dx.doi.org/10.1128/aac.01598-12.

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ABSTRACTRecent evidence indicates that immunomodulation by antibiotics may enhance their clinical efficacy. Specifically, drug-induced leukocyte apoptosis and macrophage efferocytosis have been shown to promote the resolution of inflammation in a variety of disease settings. Tulathromycin is a new macrolide antibiotic for the treatment of bovine respiratory disease. The direct antimicrobial effects of the drug alone do not fully justify its superior clinical efficacy, and we hypothesize that tulathromycin may have immunomodulating properties. We recently reported that tulathromycin promotes ap

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Kolawole, Abimbola Olayinka, and Fred Miller McCorkle. "Cyclophosphamide effects on avian macrophages in vitro (52.10)." Journal of Immunology 178, no. 1_Supplement (2007): S101. http://dx.doi.org/10.4049/jimmunol.178.supp.52.10.

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Abstract Cyclophosphamide is an alkylating agent used in the treatment of a variety of cancers. It has been shown to cause immunodepression by reducing T cell, B cell and antibody production, but little is known about the effects of the drug on macrophages. Avian macrophages are good models for human macrophages because they have the same functions in maintaining immunity. This study examined the cytotoxic effect of cyclophosphamide on the activated avian macrophage cell line MQ-NCSU, as well as the effects of the drug on attachment to a plastic substrate, phagocytosis, nitrite production and

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Davoodvandi, Amirhossein, Roxana Sahebnasagh, Omid Mardanshah, et al. "Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects." Current Pharmaceutical Design 25, no. 30 (2019): 3225–38. http://dx.doi.org/10.2174/1381612825666190829154934.

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Macrophages are one of the crucial mediators of the immune response in different physiological and pathological conditions. These cells have critical functions in the inflammation mechanisms that are involved in the inhibition or progression of a wide range of diseases including cancer, autoimmune diseases, etc. It has been shown that macrophages are generally divided into two subtypes, M1 and M2, which are distinguished on the basis of their different gene expression patterns and phenotype. M1 macrophages are known as pro-inflammatory cells and are involved in inflammatory mechanisms, whereas

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Dukhinova, Marina S., Artur Y. Prilepskii, Alexander A. Shtil, and Vladimir V. Vinogradov. "Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions." Nanomaterials 9, no. 11 (2019): 1631. http://dx.doi.org/10.3390/nano9111631.

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Macrophages are components of the innate immune system that control a plethora of biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes depending on the cue; however, polarization may be altered in bacterial and viral infections, cancer, or autoimmune diseases. Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. Macrophages can recognize and engulf nanoparticles, while the influence of macrophage-nanoparticle interaction on cell po

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Kubick, Norwin, Marta Pajares, Ioana Enache, Gina Manda, and Michel-Edwar Mickael. "Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach." Molecules 25, no. 9 (2020): 2155. http://dx.doi.org/10.3390/molecules25092155.

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Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently, the most commonly used antidepressants such as Zoloft and Citalopram can reduce inflammation, but suffer from dangerous side effects without offering specificity toward macrophages. We employed a new strategy for drug repurposing based on the integration of RNA-seq analysis and

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Dolmatova, Lyudmila S., and Igor Yu Dolmatov. "Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates." Marine Drugs 18, no. 1 (2020): 37. http://dx.doi.org/10.3390/md18010037.

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Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrop

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Zhang, Linping, Yanting Zhu, Xiaoming Wang, Zhenjiang Li, and Qianlan Dong. "Immuno-Nanoparticles Developed Using Dexamethasone and Captopril Co-Loaded PLGA Improve Glomerulonephritis Through Modulating Macrophage Polarization." Journal of Biomedical Nanotechnology 19, no. 10 (2023): 1685–96. http://dx.doi.org/10.1166/jbn.2023.3615.

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The purpose of this study was to prepare liposome-coated poly(lactic-co-glycolic acid) co-loaded with dexamethasone (DXMS, D) and captopril (CAP, C) loading with PLGA nanoparticles (P) and modified polyethylene glycol and integrin α8 antibody on the surface of nanoparticles to obtain double-drug-loaded core–shell immunoliposome composite nanoparticles (DCPI), and then studied the loading Kidney targeting, anti-inflammatory effects and effects on macrophage differentiation of drug nanoparticles. In vitro cell experiments showed that DCPI could reduce the secretion of M2 macrophage-specific cyto

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Liu, Can, Wenyi Wang, Kaixin Zhang, et al. "Protective Effects of Polydatin from Grapes and Reynoutria japonica Houtt. on Damaged Macrophages Treated with Acetaminophen." Nutrients 14, no. 10 (2022): 2077. http://dx.doi.org/10.3390/nu14102077.

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The unregulated use of acetaminophen (APAP), an antipyretic and analgesic drug, harms hepatocytes and kidney cells, leading to liver failure and acute kidney injury. Herein, we investigate whether APAP damages macrophages in the immune system by observing its effects on macrophage proliferation and apoptosis. Using proteomics, we analyzed the effects of APAP on macrophage protein expression profiles and evaluated whether polydatin, the active ingredient in grapes and wine, can repair the damaged cells. The results showed that APAP alters the morphology and physiological processes of macrophage

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Misra, Uma K., Govind Gawdi, and Salvatore V. Pizzo. "Cyclosporin A Inhibits Inositol 1,4,5-Trisphosphate Binding to Its Receptors and Release of Calcium from Intracellular Stores in Peritoneal Macrophages." Journal of Immunology 161, no. 11 (1998): 6122–27. http://dx.doi.org/10.4049/jimmunol.161.11.6122.

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Abstract We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for α2-macroglobulin, bradykinin, epidermal growth factor, and platelet-derived growth factor. Preincubation of cells with CsA (500 ng/ml), either alone or with the various ligands, did not inhibit the synthesis of IP3. However, we observed 70–80% inhibition of the binding of [3H]IP3 to IP3 receptors on macrophage membranes isolated from CsA-treated macrophages. Preincub

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Taghizadeh, Eskandar, Forough Taheri, Pedram G. Renani, Željko Reiner, Jamshid G. Navashenaq, and Amirhossein Sahebkar. "Macrophage: A Key Therapeutic Target in Atherosclerosis?" Current Pharmaceutical Design 25, no. 29 (2019): 3165–74. http://dx.doi.org/10.2174/1381612825666190830153056.

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Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages are derived from circulating monocytes and form fatty streaks as the first step of atherogenesis. Methods: An electronic search in major databases was performed to review new therapeutic opportunities for influencing the inflammatory component of atherosclerosis based on monocytes/macrophages targeting. Results: In the past two decades, macrophages have been recognized as the main players in atherogenesis but also in its t

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Dissertations / Theses on the topic "Macrophages/drug effects"

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Bondeson, Jan. "Effects of disease-modifying antirheumatic drugs on macrophage signal transduction and the induction of proinflammatory cytokines." Lund : Section of Molecular Pathogenesis, Dept. of Cell and Molecular Biology, Lund University, 1996. http://books.google.com/books?id=dgxsAAAAMAAJ.

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Kimakhe, Saïd. "Effets biologiques bacteriologiques et pharmacologiques de la polymyxine b apportee in situ par des materiaux biodegradables (doctorat : odontologie et biomateriaux)." Nantes, 1998. http://www.theses.fr/1998NANT020D.

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"A biochemical study of cell death in murine PU5-1.8 cells." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5895770.

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by Chan Chun-wai, Francis.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 105-116).<br>Abstract --- p.I<br>Acknowledgments --- p.III<br>Abbreviations --- p.IV<br>Objectives --- p.VI<br>Content --- p.VII<br>Chapter Section 1 --- Introduction<br>Chapter I. --- Preamble --- p.1<br>Chapter II. --- Characteristics of Cell Death Process --- p.1<br>Chapter II.1. --- Necrosis --- p.1<br>Chapter II.2. --- Apoptosis-Programmed Cell Death --- p.5<br>Chapter III. --- Triggering of Programmed Cell Death --- p.10<br>Chapter IV. --- DNA Fr

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Ding, Hui Ru, and 丁慧如. "Mechanism of suppressive effect of B-adrenergic drug on the activation of macrophages induced by endotoxin." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/55764228628248351632.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>83<br>LPS is one component of G(-) bacteria's outer membrane. In sepsis patient, LPS was released to the circulatory system and then markedly activated immune cells. The activated macrophages would produce inflammatory substances, such as cytokines, arachi-donate metabolites, nitric oxide, etc. In the paper, we attempted to investigate the effects of catecholamines on the production of TNFα and nitric oxide (NO) from the isolated mouse peritoneal macrophages activated by LPS. The results showed that α1-agonist, phenyleph

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"The effect of danshen-gegen compound formula on in vitro foam cell formation and in vivo antioxidant level." 2007. http://library.cuhk.edu.hk/record=b5893290.

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Wong, Wai Yin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 92-108).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Atherosclerosis --- p.1<br>Chapter 1.1.1 --- Pathogenesis of Atherosclerosis --- p.2<br>Chapter 1.1.2 --- Atherosclerosis and Cardiovascular Disease --- p.4<br>Chapter 1.2 --- Cardiovascular Disease (CVD) --- p.5<br>Chapter 1.2.1 --- Term Definition --- p.5<br>Chapter 1.2.2 --- Risk Factors --- p.6<br>Chapter 1.2.3 --- Current Western Medications --- p.7<br

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Books on the topic "Macrophages/drug effects"

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Roland, Mertelsmann, and Herrmann Friedhelm 1949-, eds. Hematopoietic growth factors in clinical applications. Dekker, 1990.

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M, Berry, and Logan Ann, eds. CNS injuries: Cellular responses and pharmacological strategies. CRC Press, 1999.

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Gordon, Siamon. Macrophage As Therapeutic Target. Springer London, Limited, 2012.

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Gordon, Siamon. The Macrophage as Therapeutic Target. Springer, 2012.

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Berry, Martin. CNS Injuries: Cellular Responses and Pharmacological Strategies. Taylor & Francis Group, 2019.

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Berry, Martin. CNS Injuries: Cellular Responses and Pharmacological Strategies. Taylor & Francis Group, 2019.

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Berry, Martin. CNS Injuries: Cellular Responses and Pharmacological Strategies. Taylor & Francis Group, 2019.

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Berry, Martin, and Ann Logan. CNS Injuries: Cellular Responses and Pharmacological Strategies (Pharmacology & Toxicology (Crc Pr)). CRC, 1998.

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Berry, Martin. CNS Injuries: Cellular Responses and Pharmacological Strategies. Taylor & Francis Group, 2019.

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Book chapters on the topic "Macrophages/drug effects"

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Singh, Prabhakar, Sudhakar Singh, and Rajesh Kumar Kesharwani. "Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications." In Pharmaceutical Sciences. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch018.

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In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting.

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Nath, Junmoni, Chayanika Bordoloi, Alakesh Bharali, Bhanu P. Sahu, and Damiki Laloo. "Recent Updates in Natural Product Research and Novel Approaches to Drug Delivery Using Phytomolecules." In Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238129124030005.

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Herbal medicines are gaining popularity in the modern world for their ability to treat a wide range of ailments while having fewer side effects and greater therapeutic properties. However, there are many limitations when it comes to delivering active phytomolecules to the target site, including solubility of ingredients, susceptibility to degradation in the presence of gastric and colonic acidity, diminished metabolic efficacy attributable to gut microflora, inadequate absorption across the intestinal epithelium, suboptimal active efflux mechanisms, and susceptibility to first-pass metabolism.

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Rajasekharan Pillai, Sharika, and Siriporn Chuchawankul. "Therapeutic Scope and Application of Mushroom-Derived Pharmacoactives in Enhancing Health." In Biotechnology and Drug Development for Targeting Human Diseases. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238273124020006.

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In the present era, the notion that “prevention is better than cure” has gained impetus with increased incidences of infectious and degenerative lifestyle diseases. Recent years have seen many people choosing functional food such as probiotics, plant-based nutritional supplements, and their normal dietary needs. Studies have shown significant health benefits in using these nutraceuticals as they aid in the body's general well-being. Among food varieties, edible mushrooms have also become a functional dietary food. It has been used as a source of nutrition in many parts of the world. Oriental m

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Peine, Kevin J., Naihan Chen, Eric M. Bachelder, and Kristy M. Ainslie. "Drug Delivery Strategies for Tolerogenic Therapy for Autoimmune Diseases in an Antigen-Specific Manner." In Chronic Illness and Long-Term Care. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7122-3.ch007.

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Autoimmune diseases are the result of an improper immune response towards a self-antigen. Predominantly, autoimmune diseases have been treated using therapies that suppress systemic immune responses, which can result in significant side-effects like increased risk of infection and cancer. Alternatively, induction of immune tolerance through antigen-specific therapies can inhibit disease-associated responses without systemic suppression. Previously, immune tolerance has been accomplished by soluble antigen delivery through oral, nasal or sublingual routes. However, these therapies have shown mi

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Shaikh, Zuber Peermohammed. "Pharmacology of Different Immunity Cell Components and Growth Factors." In Cancer Diagnosis, Treatment and Care. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-5400-1.ch015.

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Tumor-associated macrophages are immune cells that regulate various factors in the tumor microenvironment and play an important role in connecting cancer with various immune cells in the tumor microenvironment. Recently, these tumor-associated macrophages have also been recognized as biomarkers for the treatment of cancer, and anti-cancer drugs have been developed targeting them. This new therapeutic approach is to achieve the effect of reprogramming immune cells to attack cancer cells by combination therapy with immune checkpoint inhibitors and a next-generation immuno-oncology drugs develope

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Enrico Lombardo, Giovanni, Alessandro Maugeri, Caterina Russo, Laura Musumeci, Santa Cirmi, and Michele Navarra. "Anti-inflammatory Activity Methods." In Methods for Preclinical Evaluation of Bioactive Natural Products. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123043123010005.

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The inflammatory process can be unleashed by a wide variety of biological, chemical, and physical factors, and arises to counteract these dangerous enemies. In case of failure by the organism to defeat these exogenous stimuli, a chronic inflammatory status occurs, hence potentially leading to several diseases. Therefore, anti-inflammatory drugs, from both synthetic and natural sources, represent valuable allies to fight the phlogistic process. The search for novel candidate drugs is never ceasing, also from the plant kingdom, known to provide products with generally lesser or more tolerable si

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Taghipour, Reza, Hadi Hassannia, Hesamoddin Arabnozari, Seyed Ehsan Enderami, and Emran Habibi. "Natural Polysaccharides in Breast Cancer: Fucoidan’s Role in Enhancing Cisplatin Cytotoxicity and Reducing Chemotherapy Resistance." In Latest Research on Breast Cancer [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1007395.

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Cancer is one of the leading causes of death worldwide. Recent advancements in chemotherapy, particularly using natural drug-based strategies, have shown promise. This study evaluated the antitumor and anti-inflammatory effects of a combination of the brown alga Sargassum ilicifolium with cisplatin in vitro. After collecting and identifying the algae, fucoidan and alginate were extracted. The antioxidant activity was assessed using DPPH and Ferric Reducing Ability of Plasma (FRAP) assays. The cytotoxic effects on the MDA-MB-231 breast cancer cell line were evaluated in both 2D and 3D cultures

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Pedro Lapuente, Juan. "Immunomodulatory Effects of a M2-Conditioned Medium (PRS^® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System." In Purinergic System [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104486.

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Co-culture of primary or mesenchymal stem cells (MSC) with M2 macrophages produces a very special conditioned medium with a recognizable and stable cytokine pattern (PRS CK STORM), independent of the donor, with unique anti-inflammatory properties. This product can regulate certain pathways of inflammation in an anti-inflammatory manner, including TLR3, TLR4, the inflammasome, and the purinergic system. The anti-inflammatory action of PRS CK STORM is demonstrated both by its composition and by its action in in vitro and in vivo inflammatory models. The study of the mechanism of action showed c

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"Macrophage colony-stimulating factor (M-CSF)." In Meyler's Side Effects of Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.01010-6.

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"Granulocyte–macrophage colony-stimulating factor (GM-CSF)." In Meyler's Side Effects of Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.00823-4.

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Conference papers on the topic "Macrophages/drug effects"

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Quinn, T., A. Pellicoro, C. Lochenie, et al. "Dynamic microscopic imaging and molecular characterisation of alveolar macrophage drug effects of a labelled inflammasome inhibitor in the human lung." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.1475.

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Smolianova, N. A., N. V. Lekontceva, and A. D. Nikulin. "STUDY OF THE INTERACTION OF COLD SHOCK PROTEINS FROM MYCOBACTERIUM TUBERCULOSIS WITH SRNAS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-272.

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Tuberculosis is a common infection affecting both humans and animals. The disease is caused by various strains of Mycobacterium tuberculosis, which causes about two million deaths worldwide each year. Once infiltrated into the host, mycobacteria inhibit autophagy and intercellular signaling, they are also resistant to toxic substances, which ensures their survival within macrophages. M. tuberculosis exhibits a high degree of genetic diversity, which contributes to their resistance to drugs. The emergence of multidrug-resistant strains (MDRTB) is a serious public health problem, complicating th

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Reports on the topic "Macrophages/drug effects"

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu

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