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Dissertations / Theses on the topic 'Male wistar rats'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wickens, Nicolas John. "Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/4742.

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In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High

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2

Hart, Michael. "Sry1 decreases urinary sodium excretion in the kidney of male wistar kyoto rats." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1195232446.

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3

Raji, Ismaila. "Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive wistar rats." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5212_1367481132.

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<p>Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this&nbsp<br>herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study&nbsp<br>was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats<br>&nbsp<br>and to find out the mechanism(s) by whic

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4

Nyuyki, Kewir [Verfasser], and Inga [Akademischer Betreuer] Neumann. "Consequences of chronic psychosocial stress in male wistar rats / Kewir Nyuyki. Betreuer: Inga Neumann." Regensburg : Universitätsbibliothek Regensburg, 2012. http://d-nb.info/1031558713/34.

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5

Arokoyo, Dennis Seyi. "Antidiabetic and profertility mechanisms of aqueous extract of Basella alba in male Wistar rats." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2736.

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Thesis (PhD (Biomedical Sciences))--Cape Peninsula University of Technology, 2017.<br>The use of medicinal plants in the management of various health problems date back to the ancient times. However, only in recent years, researchers are starting to focus on the use of natural plant products as alternative treatment in disease control. Basella alba (Ba), commonly called Ceylon or Indian spinach is one of such medicinal plants, wildly cultivated and consumed mostly as vegetable. Studies have established many beneficial effects of Ba, including androgenic effects as well as antidiabetic effects

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6

Omodanisi, Elizabeth Ife. "Modulatory effects of Moringa oleifera extracts on Streptozotocin-induced diabetes in male Wistar rats." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2558.

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Thesis (DTech (Biomedical Technology))--Cape Peninsula University of Technology, 2017.<br>Diabetes mellitus (DM) is characterized by deficiency in insulin resulting in hyperglycaemia with metabolic alterations in carbohydrate, lipid and protein. DM has been associated with increased formation of reactive oxygen species (ROS) and inflammatory mediators. Many drugs have been designed for its treatment and management; however, limitations persist in the use of anti-hyperglycemic medications due to numerous side effects, high cost, limited action and secondary failure rates. Moringa oleifera (MO)

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7

Nyuyki, Kewir [Verfasser], and Inga D. [Akademischer Betreuer] Neumann. "Consequences of chronic psychosocial stress in male wistar rats / Kewir Nyuyki. Betreuer: Inga Neumann." Regensburg : Universitätsbibliothek Regensburg, 2012. http://d-nb.info/1031558713/34.

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8

Buczek, Yvona. "The effect of chronic environmental and pharmacological stress on ethanol consumption in male Wistar rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27613.pdf.

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9

Tili, Siphokazi Pamphilia. "Observed pathological changes in male Wistar rats after co-treatment of Type II Diabetes with metformin and sutherlandia frutescens." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1012644.

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Diabetes is a serious condition that affects all the body’s systems including kidneys, heart, eyes and limbs. This alone makes type II diabetes a life threatening disease; an expensive disease and economic burden that many individuals struggle to cope with.The rapid growth type II diabetes in South Africa is associated with the change of life style, and environmental factors brought by westernized way of life living in rural areas. Despite the technical advances in diagnosis and therapy of diabetes many people still use alternative forms of therapy due to the cost, traditional reasons and reli

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10

Moledina, Altaf. "The social competition test as an animal model of anxiety in triads of male Wistar rats." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341641.

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11

Jordaan, Audrey Emmerentia. "The effects of the wild african potato (hypoxis hemerocallidea) supplementation on streptozotocin-induced diabetic wistar rats reproductive function." Thesis, Cape Peninsula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2234.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2015.<br>Diabetes mellitus (DM) has been reported to be one of the greatest global public health threats. Statistics of the fertility status of modern society has linked increased DM to a decrease in fertility rates. Hyperglycaemia is characteristic of DM that results in a disturbance of proteins, lipids and carbohydrate metabolism leading to an increase production of reactive oxygen species (ROS). In the case where ROS overwhelms antioxidant mechanisms, the body goes into state of oxidative stress (OS). OS plays

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12

Goboza, Mediline. "The biochemical effects of Hypoxis hemerocallidea in the kidney and liver of streptozotocin-induced diabetic male Wistar rats." Thesis, Cape Peninisula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2233.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2015.<br>Diabetes mellitus (DM) is an endocrine disorder that is characterised not only by severe hyperglycemia but also altered metabolism of glucose and lipids. It is a major health problem worldwide and its impact is greatly noticed in developing countries due to the lack of adequate medical facilities. Oxidative stress remains the principal factor that actively plays major roles in the onset and progression of diabetes mellitus and its complications. The use of medicinal plants in the treatment of DM has undis

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13

Chadwick, Wayne. "Observed metabolic changes in male Wistar rats after treatment with an antidepressant implied in undesirable weight gain, or Sutherlandia frutescens for Type II diabetes." Thesis, University of Port Elizabeth, 2003. http://hdl.handle.net/10948/313.

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Type II diabetes is fast becoming a growing problem in developed countries worldwide. Traditionally the median age for diagnosis was around sixty, but recent surveys have shown that the entire age distribution curve has shifted to the left. Western countries boast the worst statistics in which type II diabetes is being reported in children under the age of ten. At such a young age the disease often goes undiagnosed for long periods of time allowing considerable damage to occur. The incidence of type II diabetes is thought to be parallel with the growing rate of obesity associated with a charac

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14

Kachepe, Prisca. "The possible therapeutic effects of vindoline on testicular and epididymal function in diabetes-induced oxidative stress male Wistar rats." Thesis, Cape Peninsula University of Technology, 2018. http://hdl.handle.net/20.500.11838/3084.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2018<br>Diabetes mellitus is defined as a group of metabolic disorders characterised by chronic hyperglycaemia due to insufficient production and/or action of insulin and is regarded as one of the major sources of morbidity, mortality and economic burden to the modern society. A large body of scientific evidence support the fact that oxidative stress is elevated in diabetic conditions. Oxidative stress plays a significant role in the development of secondary complications of diabetes including diabetes-linked male s

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15

Waldherr, Martin. "Effects of mating on behavioral, neuroendocrine and neuronal responses to stressful stimuli in male and female Wistar rats : involvement of brain oxytocin." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1241/.

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16

Högman, Cecilia. "Explorative strategies in the open field (OF), elevated plus maze (EPM) and multivariate concentric square fieldTM (MCSF) in adolescent male Wistar rats." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220274.

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Mental disorders, like anxiety and depression, are a major health problem and can appear early in life. Developing new compounds for anxiety and other mental disorders is desirable and requires good animal models. Two widely used tests to evaluate fear and anxious behavior in rodents are the open field (OF) and elevated plus maze (EPM) tests. The models are simple and it has been argued that different environments give different behavior profiles and measure different kind of behavior. The multivariate concentric square fieldTM (MCSF) is a new test that gives the rodent opportunity to visit di

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17

Yulius, Hermanto. "Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia." Kyoto University, 2019. http://hdl.handle.net/2433/242389.

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18

Chadwick, Wayne. "Metabolic effects brought about by tricyclic antidepressants and the contribution of a medicinal plant in alleviating high fat diet induced insulin resistance in male wistar rats." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/461.

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Type II diabetes is becoming a growing problem in developed countries worldwide. The median age for diagnosis was around sixty, but recent surveys have shown that the entire age distribution curve shifting left. The incidence of type II diabetes is thought to be parallel with the growing rate of obesity associated with an unhealthy western diet. Type II diabetes is an expensive disease to manage, it is for this reason that cheaper medication needs to be investigated in the form of traditional plants, such as Sutherlandia frutescens. Prescription medication, such as tricyclic antidepressants, m

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19

Perobelli, Juliana Elaine 1985. "Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316201.

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Orientador: Wilma De Grava Kempinas<br>Texto em português e inglês<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T10:45:10Z (GMT). No. of bitstreams: 1 Perobelli_JulianaElaine_D.pdf: 9640563 bytes, checksum: dea242a152c4f569490c3cdf5d5010c1 (MD5) Previous issue date: 2012<br>Resumo: Os desreguladores endócrinos são agentes químicos capazes de agir como agonistas ou antagonistas dos hormônios endógenos, interferindo na homeostasia do organismo. Como o sistema endócrino tem papel crítico sobre o desenvolvimento e função

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20

Ajuwon, Olawale Razaq. "Improved modulation of the endogenous antioxidant system and inflammatory responses in male wistar rats by rooibos (Aspalathus linearis) and red palm oil (Elaeis guineensis)." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/1516.

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Thesis submitted in fulfilment of the requirements for the degree Doctor of Technology: Biomedical Technology In the Faculty of Health and Wellness Sciences At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY, 2012<br>Oxidative stress and chronic (low-grade) inflammation are inseparably interconnected and both have been implicated in the aetiology of many disease states. The use of plant extracts for disease prevention and therapeutic purposes, is gaining more attention because of the health benefits of the bioactive phytochemicals in these extracts. This thesis reports on the antioxidant status, t

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21

Goboza, Mediline. "Modulatory and antidiabetic effects of vindoline and Catharanthus roseus in type 2 diabetes mellitus induced male Wistar rats and in RIN-5F cell line." Thesis, Cape Peninsula University of Technology, 2019. http://hdl.handle.net/20.500.11838/2878.

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Thesis (DPhil (Biomedical Science))--Cape Peninsula University of Technology, 2019.<br>Diabetes mellitus (DM) is a group of metabolic disorders characterised by persistent high blood glucose levels together with abnormal metabolism of macromolecules. If the hyperglycemia is not controlled, adverse metabolic changes could occur leading to the progressive development of severe complications. Formation of reactive oxygen/nitrogen species and inflammatory responses are principal mechanisms that have been implicated in the development of hyperglycemia-induced tissue damage. The commercially availab

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22

Ayepola, Omolola Rebecca. "Effects of kolaviron–a Garcinia kola biflavonoid on biochemical and histological parameters in streptozotocin - induced diabetes and diabetic complications (nephrotoxicity and hepatotoxicity) in male Wistar rats." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/1512.

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Thesis submitted in fulfillment of the requirements for the Doctor of Technology: Biomedical Technology In the Faculty of Health and Wellness At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY 2014<br>Diabetes mellitus (DM) results in severe metabolic imbalances and pathological changes in many tissues. Chronic inflammation and oxidative stress have been implicated in the pathophysiology of diabetes mellitus. Garcinia kola (Family: Guttiferae) is a plant well known for its ample medicinal values. The seed of the plant also known as ‘bitter kola’ due to its bitter taste is used as a masticatory age

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23

Faccio, Luciana. "Influência da infecção por Trypanosoma evansi sobre hormônios do sistema reprodutivo de ratos experimentalmente infectados." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/10141.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Infection by Trypanosoma evansi causes various pathological changes in animals, as well as reproductive problems whose pathogenesis is not fully known. Therefore, the objective of this study was to evaluate the serum concentrations of reproductive hormones, histopathology and biomarkers of oxidative stress in testicles of rats experimentally infected with T. evansi. Twenty four animals were divided in two groups with 12 animals each. Group A was formed by healthy Wistar rats (uninfected) and group B composed by animals infected wit

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24

Bolotari, Mariana. "Efeitos de diferentes tipos de treinamento físico nos parâmetros reprodutivos de ratos Wistar superalimentados na infância." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/6630.

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Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-04-10T11:32:22Z No. of bitstreams: 1 marianabolotari.pdf: 1634687 bytes, checksum: 9aff6476532e85dd9adfaebe0c08ab08 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-04-10T11:55:38Z (GMT) No. of bitstreams: 1 marianabolotari.pdf: 1634687 bytes, checksum: 9aff6476532e85dd9adfaebe0c08ab08 (MD5)<br>Made available in DSpace on 2018-04-10T11:55:38Z (GMT). No. of bitstreams: 1 marianabolotari.pdf: 1634687 bytes, checksum: 9aff6476532e85dd9adfaebe0c08ab08 (MD5) Previous issue date: 2018-03-

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25

Hellman, Urban. "About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling." Doctoral thesis, Umeå universitet, Medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35491.

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Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. Furthermore, signal transduction, molecular diffusion and microcirculation will be affected in the hypertrophic process. One important extracellular component is the glycosaminoglycan hyaluronan. It has been shown to play a major role in other condi

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26

Nadeau, Bryan G. "Response to cold challenge in male Wistar rats maintained in constant illumination." Thesis, 1992. http://spectrum.library.concordia.ca/4114/1/MM80947.pdf.

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27

"The effect of nigella sativa oil on male reproductive function in male Wistar rats exposed to an obesogenic diet." University of Western Cape, 2020. http://hdl.handle.net/11394/7850.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Obesity is a growing public health concern globally, particularly in developed countries such as the United States (US). More than 30% of Americans are considered obese. In the past 20 years in America, incidence of obesity has increased significantly (Mokdad et al., 2003). As a consequence, the Centers for Disease Control (CDC) anticipates that 1 in 3 American adults will be diabetic by 2050 (Boyle et al., 2001; Hedley et al., 2004). The most important cause of obesity is poor nutrition, absence of physical exercise and unfavourable

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28

Blumenau, Martine. "The effects of housing, dietary changes and chronic restraint stress on body weight and metabolic parameters in the male wistar rat." Thesis, 2012. http://hdl.handle.net/10539/11992.

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This study examined the effect of prolonged differential housing and/or diet following exposure to chronic restraint stress on body weight, body fat weight, body fat composition and corticosterone, glucose, insulin and leptin levels. To this end, male Wistar rats were individually-housed (IH) or pair-housed (PH) and fed a condensed milk diet (CD) or a mushy rat chow diet (MD) for twelve weeks. Subsequently, all rats underwent chronic restraint stress (CRS) for seven hours/day for four weeks. During CRS, only PH rats fed MD continued to gain weight, while growth of the other groups was stunted.

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29

Durgiah, Raveshni. "An in vivo study to determine the effects of Ochratoxin A and Sutherlandia frutescens in male Wistar rats." Thesis, 2009. http://hdl.handle.net/10413/8606.

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Ochratoxin A (OTA), a nephrotoxic mycotoxin, is a contaminant of several agricultural food products consumed by animals and humans. Apart from renal toxicity, in particular renal tumours, OTA may also result in teratogenicity, neurotoxicity and immunotoxicity. Sutherlandia frutescens, an indigenous medicinal plant, has shown significant potential in strengthening the immune system and in cancer treatment, with minimal side effects. The objective of this study was to determine the effects of OTA in male Wistar rats and ascertain if these effects may be reduced by S. frutescens. Rats were treate

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30

Waldherr, Martin [Verfasser]. "Effects of mating on behavioral, neuroendocrine and neuronal responses to stressful stimuli in male and female Wistar rats : involvement of brain oxytocin / vorgelegt von Martin Waldherr." 2009. http://d-nb.info/998397172/34.

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31

McNeilly, A. D., Ritchie Williamson, D. J. Balfour, C. A. Stewart, and C. Sutherland. "A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin." 2012. http://hdl.handle.net/10454/6095.

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AIMS/HYPOTHESIS: We previously demonstrated that animals fed a high-fat (HF) diet for 10 weeks developed insulin resistance and behavioural inflexibility. We hypothesised that intervention with metformin would diminish the HF-feeding-evoked cognitive deficit by improving insulin sensitivity. METHODS: Rats were trained in an operant-based matching and non-matching to position task (MTP/NMTP). Animals received an HF (45% of kJ as lard; n = 24), standard chow (SC; n = 16), HF + metformin (144 mg/kg in diet; n = 20) or SC + metformin (144 mg/kg in diet; n = 16) diet for 10 weeks before retesting.

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