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1

Clavien, Pierre-Alain, and Stefan Breitenstein, eds. Malignant Liver Tumors. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444317053.

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2

Moliterno Gunel, Jennifer, Joseph M. Piepmeier, and Joachim M. Baehring, eds. Malignant Brain Tumors. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-49864-5.

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3

Rongioletti, Franco, Irina Margaritescu, and Bruce R. Smoller. Rare Malignant Skin Tumors. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2023-5.

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4

Beck, Lutwin, Ekkehard Grundmann, Rolf Ackermann, and Hans-Dietrich Röher, eds. Hormone-Related Malignant Tumors. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-83816-3.

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5

1918-, Brooks Benjy Frances, and Robert E. Gross Symposium (6th : 1984 : M.D. Anderson Hospital and Tumor Institute), eds. Malignant tumors of childhood. University of Texas Press, 1986.

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6

Thiagarajan, Balasubramanian. Malignant tumors of larynx. otolaryngology online, 2011.

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7

Lutwin, Becker, ed. Hormone-related malignant tumors. Springer-Verlag, 1990.

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8

W, Hancock Barry, ed. Malignant lymphoma. Arnold, 2000.

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9

Jellinger, Kurt, ed. Therapy of Malignant Brain Tumors. Springer Vienna, 1986. http://dx.doi.org/10.1007/978-3-7091-8876-7.

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10

Cobin, Rhoda H., and David King Sirota, eds. Malignant Tumors of the Thyroid. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4613-9127-2.

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11

Sculier, Jean-Paul, and Willard A. Fry, eds. Malignant Tumors of the Lung. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18698-1.

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12

1931-, Jellinger K., ed. Therapy of malignant brain tumors. Springer-Verlag, 1987.

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13

C, Chu A., and Edelson Richard L, eds. Malignant tumors of the skin. Arnold, 1999.

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14

1952-, Wick Mark R., ed. Pathology of unusual malignant cutaneous tumors. Dekker, 1985.

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15

T, Thomas D. G., ed. Neuro-oncology: Primary malignant brain tumors. Johns Hopkins University Press, 1990.

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16

Paul, Hermanek, Sobin L. H, and International Union against Cancer, eds. TNM classification of malignant tumours. 4th ed. Springer-Verlag, 1987.

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17

H, Sobin L., Gospodarowicz M. K, Wittekind Ch, and International Union against Cancer, eds. TNM classification of malignant tumours. 7th ed. Wiley-Blackwell, 2009.

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18

H, Sobin L., Gospodarowicz M. K, Wittekind Ch, and International Union against Cancer, eds. TNM classification of malignant tumours. 7th ed. Wiley-Blackwell, 2009.

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19

T, Thomas David G., ed. Neuro-oncology: Primary malignant brain tumours. Edward Arnold, 1990.

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20

Sand, PD Dr Michael. MicroRNAs in malignant tumors of the skin. Springer Fachmedien Wiesbaden, 2016. http://dx.doi.org/10.1007/978-3-658-12794-7.

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21

Cripe, Timothy P., and Nicholas D. Yeager, eds. Malignant Pediatric Bone Tumors - Treatment & Management. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18099-1.

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22

Streffer, Christian, ed. Hyperthermia and the Therapy of Malignant Tumors. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-82955-0.

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23

1934-, Streffer Christian, ed. Hyperthermia and the therapy of malignant tumors. Springer-Verlag, 1987.

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24

Pierre-Alain, Clavien, ed. Malignant liver tumors: Current and emerging therapies. 3rd ed. Blackwell Pub., 2010.

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25

Pierre-Alain, Clavien, ed. Malignant liver tumors: Current and emerging therapies. Blackwell Science, 1999.

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26

Pierre-Alain, Clavien, ed. Malignant liver tumors: Current and emerging therapies. 3rd ed. Blackwell Pub., 2010.

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27

Isserman, Rebecca S., and Justin L. Lockman. Intracranial Tumor. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0026.

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Intracranial tumors are the most common solid malignancy in pediatrics, with the majority found in the posterior fossa. In these patients, presenting symptoms and signs are frequently related to intracranial hypertension due to obstruction of cerebrospinal fluid flow. Specific cranial nerve palsies and ataxia may also be presenting signs, with or without intracranial hypertension. The anesthesia for surgical resection is nuanced by management of intracranial hypertension, the potential for hemodynamic instability, and postoperative complications resulting from damage to critical brainstem stru
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28

Reizenstein, P., and G. Mathe. Managing Minimal Residual Malignancy in Man (Medical Oncology and Tumor Pharmacotherapy). Elsevier Science Publishing Company, 1989.

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29

König, Matthias W., Mohamed A. Mahmoud, and John J. McAuliffe. Prone Positioning for Posterior Fossa Tumor Resection. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0037.

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Brain tumors are the second most common malignancy in children. About one third occur in toddlers under the age of 3, and about two thirds are located in the posterior fossa. Resection of posterior fossa tumors is often a lengthy procedure that is commonly performed in the prone position. The prone position is associated with physiological changes and predisposes the patient to certain types of injuries.
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30

Brown, Christina, and Meredith Kato. Neuroblastoma. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0033.

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Neuroblastoma is a solid tumor that arises from neural crest cells. It is a common cancer of childhood, accounting for 7.8% of all childhood malignancy. It affects primarily infants and toddlers with older children carrying a worse prognosis. While surgery is a primary treatment modality, these tumors are not well encapsulated and tend to invade adjacent structures making resection more difficult. As such, patients often come to the operating room after neoadjuvant chemotherapy and the surgeries can be long with large blood losses. Anesthesia for the resection for neuroblastoma must take into
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31

Andrejeva, Liva, Jaime L. Geisel, and Malini Harigopal. Spiculated Masses. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0025.

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A spiculated mass is a centrally dense lesion seen on mammography with sharp lines radiating from its margin. The spicules can vary greatly in length, from a few millimeters to several centimeters. In malignant lesions, spicules represent a mixture of tumor cells and fibrosis invading the normal tissue surrounding the lesion. Although a spiculated mass is thought of as a classic finding of malignancy on mammography, ultrasound, and MRI, its differential diagnosis includes benign lesions. However, unless clinical history strongly supports a benign diagnosis, a spiculated mass on any modality ty
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32

North, Robert, and Ganesh Rao. Medulloblastoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0006.

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Medulloblastoma is the most common brain malignancy in children. This chapter details the current diagnostic criteria, pathological classification, and treatment paradigms. Recent molecular characterization of medulloblastoma has revealed significant variations in clinical behavior of different tumor types. While the treatments for medulloblastoma are generally quite successful, with 5 year survival rates approaching 80%, the responsiveness of each subtype to treatment varies. The authors cover common clinical scenarios along with management pearls and key references.
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33

Abou-Al-Shaar, Hussam, and Mark A. Mahan. Dumbbell Nerve Sheath Tumors. Edited by Meghan E. Lark, Nasa Fujihara, and Kevin C. Chung. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190617127.003.0019.

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A dumbbell tumor is a nerve sheath tumor that arises from a spinal nerve in the neural foramen and grows as a dumbbell-shaped mass. The differential diagnosis for a dumbbell tumor includes schwannoma, neurofibroma, malignant peripheral nerve sheath tumor, and metastases, among others. MR imaging is considered the gold-standard imaging modality for diagnosis of dumbbell tumors. Surgical approaches that are tailored to the individual patient’s case can be utilized. The chapter reviews dumbbell tumors, including a case example and covers the incidence, clinical presentation, imaging features, dec
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34

Sherman, Mark E., Melissa A. Troester, Katherine A. Hoadley, and William F. Anderson. Morphological and Molecular Classification of Human Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0003.

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Accurate and reproducible classification of tumors is essential for clinical management, cancer surveillance, and studies of pathogenesis and etiology. Tumor classification has historically been based on the primary anatomic site or organ in which the tumor occurs and on its morphologic and histologic phenotype. While pathologic criteria are useful in predicting the average behavior of a group of tumors, histopathology alone cannot accurately predict the prognosis and treatment response of individual cancers. Traditional measures such as tumor stage and grade do not take into account molecular
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35

Woolf, Eric C., and Adrienne C. Scheck. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0013.

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Malignant brain tumors are devastating, and increased survival requires new therapeutic modalities. Metabolic dysregulation results in an increased need for glucose in tumor cells, suggesting that reduced tumor growth could be achieved with decreased glucose availability either through pharmacological means or use of a high-fat, low-carbohydrate ketogenic diet (KD). KD provides increased blood ketones to support energy needs of normal tissues and has been shown to reduce tumor growth, angiogenesis, inflammation, peritumoral edema, migration, and invasion. Furthermore, this diet can enhance the
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36

Hébert-Blouin, Marie-Noëlle. Malignant Peripheral Nerve Sheath Tumors. Edited by Meghan E. Lark, Nasa Fujihara, and Kevin C. Chung. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190617127.003.0020.

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Malignant peripheral nerve sheath tumors (PNSTs) are soft tissue sarcomas arising from a peripheral nerve or a pre-existing benign nerve sheath tumor or are sarcomas with features of Schwann-cell differentiation. Differentiating between benign and malignant PNSTs can be challenging. The chapter begins with a case example and then discusses assessment, investigations (including imaging), and diagnosis of malignant PNSTs, as well as the steps involved in decision-making about management of a malignant PNST. The surgical principles and goals for resection of a malignant PNST, the adjuvant therapi
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37

Kaley, Thomas J. Oligodendrogliomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0128.

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Gliomas represent the most common symptomatic primary brain tumors, of which oligodendrogliomas are the least common subtype of glioma.1 The traditional thinking is that although the rarest, they also offer patients the best prognosis and they are deemed to be the most sensitive to treatment. However, although they may have a longer average survival than most other gliomas, nearly all patients with an oligodendroglioma will ultimately succumb to their illness due to either progressive and recurrent tumor or malignant transformation into a higher grade tumor. Optimal treatment of oligodendrogli
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38

Argote-Romero, Graciela. Wilms Tumor. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0041.

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Wilms tumor, known as well as nephroblastoma, is the most common primary malignant renal tumor in children. Over 95% of all renal tumors in patients under the age of 15 are Wilms tumors. The mean age at the time of diagnosis is 3.5 years. Wilms tumors are usually an incidental finding, a large abdominal mass discovered by a family member or pediatrician. Hematuria and hypertension can be present at the time of initial diagnosis. Up to 8% of the patients will have von Willebrand disease; therefore, all patients should have baseline coagulation studies. All patients should have either computed t
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39

Raue, Friedhelm. Hypercalcemia of Malignancy. Springer, 2012.

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40

Thomas, David G. Malignant Brain Tumors. Springer, 1995.

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41

Grundmann, Ekkehard. Malignant Bone Tumors. Springer, 2011.

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42

Grundmann, Ekkehard. Malignant Bone Tumors. Springer Berlin Heidelberg, 2011.

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43

Ali-Fehmi, Rouba, and Eman Abdulfatah. Biological Aspects and Clinical Applications of Serum Biomarkers in Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0002.

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Ovarian cancer, the most aggressive gynecological malignancy, presents at advanced stages with metastatic disease. Diagnosis at an early stage is the most important determinant of survival; however, the majority of patients are asymptomatic at early stages and the current diagnostic tools used in clinics show limited success in early detection and hence the need for new diagnostic biomarkers. With the advance of techniques in genomic and proteomics, numerous biomarkers are emerging which may serve as a platform for early detection of ovarian cancer. These include gene-, protein-, miRNAs, and m
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44

Shah, Ashish H., and Jacques J. Morcos. Dermoid/Epidermoid Tumors. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0018.

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Epidermoid tumors of the central nervous system are typically found in the cerebellopontine angle or parasellar space and comprise approximately 1% of all intracranial tumors. Dermoid cysts tend to occur in midline locations. Both are derived from embryonal tissue and have classic imaging findings on computed tomography and magnetic resonance imaging. Epidermoid tumors and dermoid cysts are benign and grow slowly, although epidermoid cysts can undergo malignant transformation. Surgical decisions and approaches are based on the presenting symptoms and anatomic location of the tumor. Mollaret me
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45

TNM Interactive user's manual: An illustrated resource for the classification and staging of malignant tumours. Springer-Verlag, 1998.

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46

Denlinger, Chad, and Carolyn E. Reed. Contemporary Management of Esophageal Malignancy. Elsevier - Health Sciences Division, 2012.

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47

John, Bland-Sutton. Tumors, Innocent and Malignant. Arkose Press, 2015.

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48

Beck, Lutwin, and Paul J. Veerkamp. Hormone-Related Malignant Tumors. Springer, 2012.

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49

Smoller, Bruce R., Franco Rongioletti, and Irina Margaritescu. Rare Malignant Skin Tumors. Springer, 2014.

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50

Smoller, Bruce R., Franco Rongioletti, and Irina Margaritescu. Rare Malignant Skin Tumors. Springer New York, 2014.

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