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Journal articles on the topic 'Malignancy tumor'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Yarovoy, A. A., A. V. Kotelnikova, A. G. Galbatsova, and A. D. Matyaeva. "Retinocytoma malignancy." Russian ophthalmology of children, no. 3 (October 10, 2023): 27–32. http://dx.doi.org/10.25276/2307-6658-2023-3-27-32.

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In this article we described a clinical case where benign tumor retinocytoma were transformed into malignant tumor retinoblastoma. This work reflects the clinical picture and diagnostic methods necessary for making a clinical diagnosis. Considering the possibility of retinocytoma malignant transformation, patients should be under lifelong supervision. Key words: retinocytoma, retinoblastoma, protein p27, nonsense mutation, benign tumors in children, malignancy

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2

Hanson, Joshua Anspach, and Abiy B. Ambaye. "Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy." Archives of Pathology & Laboratory Medicine 135, no. 1 (2011): 143–46. http://dx.doi.org/10.5858/2009-0512-rsr.1.

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Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and

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Palmerini, Emanuela, Piero Picci, Peter Reichardt, and Gerald Downey. "Malignancy in Giant Cell Tumor of Bone: A Review of the Literature." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381984000. http://dx.doi.org/10.1177/1533033819840000.

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Background: Primary and recurrent giant cell tumor of bone is typically benign; however, rarely giant cell tumor of bone can undergo malignant transformation. Malignancy in giant cell tumor of bone may be primary (adjacent to benign giant cell tumor of bone at first diagnosis) or secondary (at the site of previously treated giant cell tumor of bone). Malignant giant cell tumor of bone has a poor prognosis; it is important to distinguish malignant from benign lesions to facilitate appropriate management. The true incidence of malignant giant cell tumor of bone is not known, probably owing to in

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Nanjappa, Santhosh, Saurabh Boralkar, Prasant Chandra, Samir Gupta, and Mangesh Londe. "Double Troubles – Managing a Series of Cases with Dual Primary Malignancies." Medical Journal of Dr. D.Y. Patil Vidyapeeth 18, no. 2 (2025): 312–19. https://doi.org/10.4103/mjdrdypu.mjdrdypu_531_24.

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ABSTRACT The reported incidence of multiple primary malignant tumor (MPMT) is between 0.734% and 11.7%. Double primary malignancy is the occurence of second primary malignant tumor of another organ in patients with a known malignant tumor. We present four cases with dual primary malignancy and treatment of these dual malignancies. All patients who underwent surgical treatment for cancers between April 2020 and April 2024 were reviewed, and the patients who had dual primary malignant tumors were identified. Hereby, we share our experience regarding multiple primary malignant tumors, their initi

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Pinello, Katia, Irina Amorim, Isabel Pires, et al. "Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats." Veterinary Sciences 9, no. 10 (2022): 535. http://dx.doi.org/10.3390/vetsci9100535.

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Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (sex, age, and breed), topography, and geographic location using a mixed-effects logistic regression model. Cats had a higher proportion of malignant tumors (78.7%) than dogs (46.2%), and

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Kudziev, A. V., A. S. Nazarov, Yu V. Belyakov, et al. "Surgical treatment of malignant triton tumor of the spinal root (a rare clinical observation)." Russian Neurosurgical Journal named after Professor A. L. Polenov 15, no. 2 (2023): 140–44. https://doi.org/10.56618/2071-2693_2023_15_2_140.

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Malignant newt tumor (MNT) is a highly aggressive malignant neoplasm classified as a variant of malignant peripheral nerve sheath tumor (MPNT) with rhabdomyoblast differentiation. MDRF with divergent (heterologous) differentiation with the presence of a rhabdoid component is extremely rare, accounting for 5 % of all MRRF, which accounts for approximately 2 % of all soft tissue sarcomas. A subgroup of tumors in which malignant Schwann cells coexist with malignant rhabdomyoblasts is called malignant newt tumor (MNT) [10]. In most published clinical observations, newt tumor malignancy occurs in t

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Black, Keith L., Randall A. Hawkins, Kenneth T. Kim, Donald P. Becker, Carole Lerner, and Donna Marciano. "Use of thallium-201 SPECT to quantitate malignancy grade of gliomas." Journal of Neurosurgery 71, no. 3 (1989): 342–46. http://dx.doi.org/10.3171/jns.1989.71.3.0342.

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✓ A quantitative preoperative technique using thallium-201 single-photon emission computerized tomography is described which predicts whether specific gliomas are of high- or low-grade malignancy. An index, based on the ratio of thallium uptake in the tumor versus the homologous contralateral brain, was calculated and compared with tumor histology. The index in 14 patients with low-grade malignant gliomas was 1.27 ± 0.40 in contrast to an index of 2.40 ± 0.61 in 11 patients with high-grade malignant gliomas (p < 0.0005). Whether gliomas were of low- or high-grade malignancy could be predict

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Kim, Eun Pyo, Giup Jang, Jin-Wook Kim, et al. "MicroRNA and Messenger RNA Expression Profiles in Canine Mammary Gland Tumor." International Journal of Molecular Sciences 24, no. 3 (2023): 2618. http://dx.doi.org/10.3390/ijms24032618.

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Canine mammary gland tumor (CMT) is the most frequently diagnosed neoplasm in intact female dogs. As prognosis depends on the malignancy of tumors and metastasis levels, early and accurate diagnosis are crucial for prolongation of life expectancy. The genetic similarity of dogs with humans in addition to environmental and physiological similarities make them ideal models for the study of cancer. In this study, we analyzed differentially expressed microRNAs followed by RNA-Seq to investigate the alterations in mRNA levels based on the malignancy (benign, malignant) and the biopsy locations (tum

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9

Korgali, Esat, Gokce Dundar, Gokhan Gokce, et al. "Giant Malignant Pheochromocytoma with Palpable Rib Metastases." Case Reports in Urology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/354687.

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Pheochromocytoma is a rare and usually benign neuroendocrine neoplasm. Only 10% of all these tumors are malignant and there are no definitive histological or cytological criteria of malignancy. Single malignancy criteria are the presence of advanced locoregional disease or metastases. We report a case, with a giant retroperitoneal tumor having multiple metastases including palpable rib metastases, who was diagnosed as a malignant pheochromocytoma. The patient was treated with surgery. The literature was reviewed to evaluate tumor features and current diagnostic and therapeutic approaches for p

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Salaouatchi, Mohamed Tayeb, Sandra De Breucker, Héloise Rouvière, et al. "A Rare Case of a Metastatic Malignant Abrikossoff Tumor." Case Reports in Oncology 14, no. 3 (2021): 1868–75. http://dx.doi.org/10.1159/000520385.

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Abrikossoff tumor, also called granular cell tumor (GCT), is a neoplasm of the soft tissues which is most commonly a solitary, painless, and benign tumor. However, 2% of Abrikossoff tumors can be malignant. We report here the case of a 75-year-old male who presented a local recurrence of Abrikossoff tumor of the left thigh. The anatomopathological analysis concluded to a malignant GCT, and the F-18 fluorodeoxyglucose positron emission tomography showed multiple lesions in the lymph nodes and bones. The potential conversion to malignancy should alert practitioners because of the extremely poor

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Okonogi, Shinichi, Shuuhei Kubota, Yuuki Sakaeyama, et al. "NI-03 USEFULNESS OF IMP-SPECT IN PREOPERATIVE GRADE EVALUATION OF INTRAORBITAL TUMOR." Neuro-Oncology Advances 1, Supplement_2 (2019): ii26. http://dx.doi.org/10.1093/noajnl/vdz039.116.

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Abstract INTRODUCTION The frequency of intraorbital tumors is small as 0.9% of all brain tumors, but its pathological type is diverse. Among them, the diagnosis of whether particularly malignant tumor scan clinically, is extremely important. Nuclear medical testing is essential for non-invasive differential diagnosis in brain tumors. SPECT, good malignancy differentiation, evaluation of malignancy, usefulness such as differentiation of non-tumorous lesions have been reported many. However, there are few reports that SPECT was useful in preoperative differential diagnosis of orbital tumors. Sin

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Gulbahce, H. Evin, Arthur T. Lindeland, William Engel, and Tamera J. Lillemoe. "Metastatic Leydig Cell Tumor With Sarcomatoid Differentiation." Archives of Pathology & Laboratory Medicine 123, no. 11 (1999): 1104–7. http://dx.doi.org/10.5858/1999-123-1104-mlctws.

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Abstract Leydig cell tumors of the testis are uncommon. Only about 10% of cases have a malignant course. It has been stated that the only definite criterion for malignancy is presence of metastasis. We present a 47-year-old patient with metastatic Leydig cell tumor 17 years after initial diagnosis, to our knowledge the longest reported interval between diagnosis and the development of metastasis. The primary tumor did not exhibit convincing features of malignancy. The initial metastasis in the right perirenal fat tissue showed a biphasic tumor with sarcomatoid differentiation not described pre

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Verma, Nidhi, Vandana Tiwari, S. P. Sharma, Preeti Singh, Monika Rathi, and Tushar Gupta. "Clinico-pathological correlation of ovarian tumors and tumor like lesions with role of CA125 and HE4 as biomarkers for discrimination of benign and malignant ovarian tumors." International Journal of Research in Medical Sciences 6, no. 7 (2018): 2238. http://dx.doi.org/10.18203/2320-6012.ijrms20182426.

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Background: Ovarian tumors and tumor like lesions of ovary frequently form pelvic masses and are associated with hormonal manifestations. Clinically or surgically they can mimic malignancy but pathologically they could be benign tumors or tumor like lesions.Methods: The aim of present study is to do clinico-histopathological correlation of ovarian tumors and tumor like lesions of ovary and also evaluate the role of serum CA125, HE4 and calculate risk of ovarian malignancy algorithm (ROMA), for differentiation of benign and malignant ovarian tumors.233 cases of ovarian tumors and tumor like les

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Yamauchi, Hayato, Shinji Sakurai, Ritsuko Tsukagoshi, et al. "A Case of Very Well-Differentiated Adenocarcinoma With Carcinoid Tumor in the Ascending Colon." International Surgery 99, no. 2 (2014): 132–36. http://dx.doi.org/10.9738/intsurg-d-13-00041.1.

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Abstract Malignant tumors with mixed glandular and neuroendocrine characteristics with at least 30% of each component are classified as mixed adenoneuroendocrine carcinoma (MANEC) by the World Health Organization 2010 classification. We report here a case of very well-differentiated adenocarcinoma accompanied by carcinoid tumor, categorized as MANEC. A 41-year-old Japanese man was clinically diagnosed with ascending colon cancer and underwent right hemicolectomy. Using an immunohistologic technique, the pathologic diagnosis was very well-differentiated adenocarcinoma accompanied by carcinoid t

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15

Shavirin, A. B., and S. I. Lipkin. "About Primary Malignant Chondroblastoma." N.N. Priorov Journal of Traumatology and Orthopedics 5, no. 1 (1998): 61–62. http://dx.doi.org/10.17816/vto104403.

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According to the WHO histological classification of tumors (1972), chondroblastoma of bone belongs to benign cartilage-forming tumors. However, later literature data indicate the possibility of its malignancy. T.P. Vinogradova mentions its malignant form along with benign chondroblastoma, noting that "each benign form of tumor, as a rule, has its malignant analogue". There are 20 cases of malignant chondroblastoma described in the world literature and there are brief mentions of another 8 such cases. The work of V.N. Burdygin, A.K. Morozov and S.I. Lipkin [1] reports 6 own observations, A.K. M

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Ahem, Terry E., R. Curtis Bird, Allison E. Church Bird, and Lauren G. Wolfe. "Expression of the oncogene c-erbB-2 in canine mammary cancers and tumor-derived cell lines." American Journal of Veterinary Research 57, no. 5 (1996): 693–96. http://dx.doi.org/10.2460/ajvr.1996.57.05.693.

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Abstract Objective To determine, for canine mammary tumors, whether malignancy, with or without local invasion or regional metastasis, was associated with overexpression of the oncogene c-erbB-2. Design c-erbB-2 expression was measured in canine mammary tumor-derived cell lines and in mammary tumor tissues from clinical cases. Clinical samples were examined histologically to determine whether they were benign or malignant and, if malignant, whether they had evidence of local invasion or regional metastasis. Canine fibroblast cultures and normal canine mammary epithelial tissues were used as re

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Pangaribuan, Machyuddin Tumpak Marojahan, Renardy Reza Razali, and Darmawi Darmawi. "Diagnostic Accuracy of CA-125 Levels for Ovarian Tumor Patients with Suspected Malignancy." Indonesian Journal of Cancer 19, no. 1 (2025): 1–8. https://doi.org/10.33371/ijoc.v19i1.1159.

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Background: Ovarian cancer is a deadly gynecological cancer that appears in ovarian tissue. To detect earlier stages of ovarian cancer and prevent unnecessary surgery, an examination and screening strategy with higher sensitivity and specificity levels are needed. The CA-125 examination is available at Arifin Achmad Hospital and has often been performed on ovarian tumor patients with suspected malignancy. Currently, the accuracy of the CA-125 examination still raises debate in diagnosing malignant ovarian tumors. This study aims to determine the diagnostic accuracy of CA-125 levels in diagnosi

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Chang, W. C., B. C. Sheu, M. C. Lin, S. N. Chow, and S. C. Huang. "Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report." International Journal of Gynecologic Cancer 15, no. 3 (2005): 549–53. http://dx.doi.org/10.1136/ijgc-00009577-200505000-00022.

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Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms. To date, we cannot accurately predict the patients who are prone to an aggressive course of disease. Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy. Foci of intraepithelial carcinoma (about 10%) without stromal invasion are also noted. Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were per

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Khatoon, Farhana, Shirin Akter Begum, Nazneen Choudhury, Sabiha Yeasmin, and Monowara Begum. "Clinical Spectrum and Management of Ovarian Masses in Children and Adolescent up to 20 Years of Age." Bangladesh Medical Journal 50, no. 1 (2021): 1–9. http://dx.doi.org/10.3329/bmj.v50i1.58246.

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Pathological type as well as management of ovarian tumor in the pediatric population are different than adult women. We performed a retrospective analysis of clinical and diagnostic aspects of ovarian tumors and tumor-like lesions in girls in order to identify characteristics associated with malignancy and it’s clinical management which is different from adult women. This is a descriptive type of cross sectional study was condunted among seventy nine female children and adolescent admitted in Bangabandhu Sheikh Mujib Medical University (BSMMU) with ovarian mass from January 2017 to December 20

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Eviana, Norahmawati, Natania Nurasih Amelinda, Pandu Persada Isma Satria, Irmansyah Irsan Istan, and Darinafitri Irma. "A rare case malignant granular cell tumor of the thigh with radiological imaging likely rhabdomyosarcoma: A case report." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 247–52. https://doi.org/10.5281/zenodo.11977549.

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Granular cell tumors (GCTs) are uncommon soft tissue tumors characterized by the cytoplasmic granular appearance of the neoplastic cells. Malignant GCTs are rare neural tumors, intensely aggressive. Both the rare occurrence of malignant GCTs and its similarities in features with their benign lesions make the diagnosis of this malignancy difficult. Malignant GCTs comprise less than 2% of GCTs and are mostly found in the subcutaneous soft tissues of the lower extremities, especially the thighs. This article presents a case of a large malignant GCTs in the left thigh of a 46-year-old woman. Plain

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Platt, Jeffrey L., and Marilia Cascalho. "Cell Fusion in Malignancy: A Cause or Consequence? A Provocateur or Cure?" Cells 8, no. 6 (2019): 587. http://dx.doi.org/10.3390/cells8060587.

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Cell fusion has been observed in malignancy, and cancer cells have been found especially apt to fuse with other cells. Investigation of human and experimental malignancies suggests spontaneous fusion of normal cells can induce manifold genetic changes and manifestations of malignant transformation. Fusion of transformed cells with other cells can promote the progression of cancer to more malignant forms. However, observations in various fields suggest cell fusion also potentially contributes to natural defenses against cancer. Thus, cell fusion potentially corrects genetic and/or phenotypic ch

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Belkouchi, O., FZ Belkouchi, Y. El Allami, et al. "BILATERAL MALIGNANT OVARIAN SERTOLI-LEYDIG CELLTUMOR :A CASE REPORT." International Journal of Advanced Research 12, no. 10 (2024): 352–59. http://dx.doi.org/10.21474/ijar01/19647.

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Ovarian stromal and or sex cord tumors develop from the supportive tissue of the ovaries. Within this group of tumors, we distinguish granulosa tumors, androblastomas(Sertoli Leydig tumors), sex cord tumors with annular tubules, steroid cell tumors and fibrosarcomas. Most of these tumors synthesize ovarian hormones: estrogens, androgens and corticosteroids. Sertoli Leydig tumors are almost always benign, while others are malignant with locoregional recurrences. Their prognosis is uncertain. The poorly differentiated forms of Sertoli-Leydig tumors have a significant potential for malignancy. We

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Samedov, V. H., L. A. Naleskina, and V. D. Zakharychev. "Association between the morphological characteristics of growth and the clinical course of oral cancer." Russian Journal of Oncology 19, no. 2 (2014): 16–21. http://dx.doi.org/10.17816/onco40032.

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Clinical-morphological study based on the clinical data of 122 patients with malignant neoplasms of tongue and oral mucosa was conducted aimed at establishing an association between the morphological characteristics of malignant tumors and symptomatic progression of the tumor process conducted after treatment. It was demonstrated that all tumors with epithelial genesis, 107 represented a keratinizing squamous carcinoma, and the degree of differentiation prevailed moderately differentiated tumors (113 cases). Retrospective evaluation of the malignancy degree of tongue and oral mucosa tumors, ac

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Hulsker, Caroline C. C., Mariëtte E. G. Kranendonk, Thomas F. Eleveld, et al. "Recurrence of a Mediastinal Germ-Cell Tumor as a Somatic-Type Malignancy: A Complex Case Report." International Journal of Molecular Sciences 22, no. 17 (2021): 9310. http://dx.doi.org/10.3390/ijms22179310.

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Background and case: An adolescent male presented with a second mediastinal tumor 1.5 years after treatment of a proven malignant germ-cell tumor in that location. The differential diagnosis included a recurrent germ-cell tumor or a non-germ cell malignancy. Serum tumor markers alpha-fetoprotein (AFP) and human chorionic gonadotrophin (HCG) were negative. The first biopsy was not informative, and the second biopsy gave a broad differential diagnosis including secondary non-germ cell malignancy using histology and immunohistochemistry. DNA methylation profiling, RNA sequencing, and targeted mic

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Fiegl, Michael, Margot Haun, Anita Massoner, et al. "Combination of Cytology, Fluorescence In Situ Hybridization for Aneuploidy, and Reverse-Transcriptase Polymerase Chain Reaction for Human Mammaglobin/Mammaglobin B Expression Improves Diagnosis of Malignant Effusions." Journal of Clinical Oncology 22, no. 3 (2004): 474–83. http://dx.doi.org/10.1200/jco.2004.06.063.

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Purpose The identification of malignant cells in effusions by conventional cytology is hampered by its limited sensitivity. The aim of this study was to improve tumor cell detection in effusions by molecular approaches. Materials and Methods A total of 157 effusions from patients with tumors and 72 effusions from patients without a history or evidence of malignancy were included in this study. All effusion specimens were evaluated in parallel by cytology, fluorescence in situ hybridization (FISH) for aneuploidy, and reverse-transcriptase polymerase chain reaction (RT-PCR) for expression of hum

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Hirachan, Suzita, Yogendra P. Singh, Anamika Jha, and Usha Manandhar. "Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy." Journal of Institute of Medicine Nepal 42, no. 1 (2020): 62–64. http://dx.doi.org/10.3126/jiom.v42i1.37443.

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Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with

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Hirachan, Suzita, Yogendra P. Singh, Anamika Jha, and Usha Manandhar. "Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy." Journal of Institute of Medicine Nepal 42, no. 1 (2020): 62–64. http://dx.doi.org/10.59779/jiomnepal.1088.

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Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with

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Alcázar, Juan Luis, Laura Pineda, and Jesús Utrilla-Layna. "Predicting Malignancy in Entirely Solid-appearing Adnexal Masses on Gray-Scale Ultrasound Based on Additional Ultrasound Findings, Clinical Complaints and Biochemical Parameters: A Retrospective Study." Donald School Journal of Ultrasound in Obstetrics and Gynecology 7, no. 1 (2013): 80–85. http://dx.doi.org/10.5005/jp-journals-10009-1273.

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ABSTRACT Purpose To determine which clinical, biochemical and other sonographic parameters could be useful to predict malignancy in sonographically solid adnexal masses. Materials and methods Clinical, biochemical and other sonographic features from 227 women diagnosed as having an entirely solid adnexal mass on B-mode gray-scale ultrasound were reviewed for this retrospective study. All patients had undergone surgery and mass removal. Definitive histologic diagnosis was available in all cases. All parameters were compared to final histological diagnosis (benign or malignant) in univariate sta

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Wu, Ching-Yang, Jui-Ying Fu, Ching-Feng Wu, et al. "Malignancy Prediction Capacity and Possible Prediction Model of Circulating Tumor Cells for Suspicious Pulmonary Lesions." Journal of Personalized Medicine 11, no. 6 (2021): 444. http://dx.doi.org/10.3390/jpm11060444.

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More and more undetermined lung lesions are being identified in routine lung cancer screening. The aim of this study was to try to establish a malignancy prediction model according to the tumor presentations. From January 2017 to December 2018, 50 consecutive patients who were identified with suspicious lung lesions were enrolled into this study. Medical records were reviewed and tumor macroscopic and microscopic presentations were collected for analysis. Circulating tumor cells (CTC) were found to differ between benign and malignant lesions (p = 0.03) and also constituted the highest area und

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Singh, Madhuri, Shirish S. Chandanwale, Akshi Raj, Nayonikha Deokar, and Arpana Dharwadkar. "Histopathological Spectrum of Renal Tumors at a Tertiary Care Hospital." Asian Journal of Pharmaceutical Research and Health Care 17, no. 1 (2025): 14–19. https://doi.org/10.4103/ajprhc.ajprhc_9_24.

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Background: About 2%–3% of all adult malignancies diagnosed worldwide are renal cell carcinomas (RCCs), the most prevalent kind of renal malignancy. Renal tumors include a wide range of benign and malignant lesions, and the patterns of these lesions differ in adults and children. The most common renal tumor in childhood is Wilms tumor. Aim and Objective: The aim of this study was to examine different types of renal tumors, their incidence, and their histomorphological characteristics, as well as their relation to the patient’s age and sex. Results: During our study period of 2 years, 60 kidney

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Park, Hye Sun, Hee Jung Shin, Ki Chang Shin, et al. "Comparison of peritumoral stromal tissue stiffness obtained by shear wave elastography between benign and malignant breast lesions." Acta Radiologica 59, no. 10 (2018): 1168–75. http://dx.doi.org/10.1177/0284185117753728.

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Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and

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Sahi, Rajina, Dilip Karmacharya, Dej Kumar Gautam, Anil Bikram Karki, and Amar Shrestha. "Pattern of Major Salivary Gland Malignancy in B.P. Koirala Memorial Cancer Hospital." Journal of College of Medical Sciences-Nepal 15, no. 3 (2019): 202–5. http://dx.doi.org/10.3126/jcmsn.v15i3.23809.

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Background: Salivary gland tumors represent a different variety of histological types. The definite diagnosis of type of salivary gland tumor is required for proper treatment planning. The aim of this study was to evaluate the pattern of salivary gland malignancy in B.P. Koirala Memorial Cancer Hospital, Bharatpur, Chitwan. Methods: This cross-sectional study was carried out in patients of malignant salivary gland tumor registered in B.P. Koirala Memorial Cancer hospital retrospectively from September 2009 to August 2012. Results: Parotid gland was the most common sites for maligna

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Funakoshi, Y., H. Nakayama, K. Uetsuka, R. Nishimura, N. Sasaki, and K. Doi. "Cellular Proliferative and Telomerase Activity in Canine Mammary Gland Tumors." Veterinary Pathology 37, no. 2 (2000): 177–83. http://dx.doi.org/10.1354/vp.37-2-177.

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In canine mammary tumors, we examined the telomerase activity, proliferative activity by proliferative cell nuclear antigen (PCNA) immunohistochemistry, and percentage of apoptotic cells by the deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) method. The relationship between these measures and histopathologic malignancy was also investigated. PCNA index was highest in malignant tumors (adenocarcinoma: 27.0%; malignant mixed tumor: 15.7%), followed by benign tumors (adenoma: 4.4%; benign mixed tumor: 5.3%), hyperplasia (2.1%), and normal mammary gland (0.9%). In adeno

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Oussama, Afandi, chahid Malak, akkari Salma, and Bouknani Nawal. "Pleural malignant fibrosolitary tumor: A rare entity." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 1610–14. https://doi.org/10.5281/zenodo.12786941.

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Solitary fibrous tumors of the pleura represent a rare histological entity, belonging to the groups of pleural tumors of sub-mesothelial origin , therefore some authors evoke the hypothesis of its proliferation from submesothelial tissue of the pleura .The clinical manifestations are varied and the certain diagnostic can only be made by anatomopathological examination which evaluates precise malignancy criteria. Total surgical removal is the only way to ensure a definitive cure. We report the case of 65-year-old woman with a malignant solitary fibrous tumor operated by thoracotomy with complet

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Schmitt, William R., Matthew L. Carlson, Caterina Giannini, Colin LW Driscoll, and Michael J. Link. "Radiation-Induced Sarcoma in a Large Vestibular Schwannoma Following Stereotactic Radiosurgery: Case Report." Neurosurgery 68, no. 3 (2011): E840—E846. http://dx.doi.org/10.1227/neu.0b013e31820780b1.

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AbstractBACKGROUND AND IMPORTANCE:Stereotactic radiosurgery (SRS) has been employed with increasing frequency in the treatment of benign intracranial tumors. While the risk for radiation-induced malignancy has been well studied for fractionated external beam radiation, reports of SRS-associated malignancy have only begun to emerge over the past 10 years.CLINICAL PRESENTATION:We present a case of a rapidly enlarging, presumed sporadic vestibular schwannoma in a 51-year-old man treated with SRS. Serial imaging over the next 7.5 years demonstrated good radiographic response with consistent involu

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Bakayoko, N., E. Martin, J. Sanders, M. Zygmont, J. Hamilton, and R. Peterson. "Unique Presentation of Rare Cervical Sympathetic Chain Schwannoma." Neurographics 14, no. 2 (2024): 127–31. http://dx.doi.org/10.3174/ng.2300028.

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We describe a unique case of a cervical sympathetic chain schwannoma that presented as an ambiguous oropharyngeal mass with a differential of a benign or malignant salivary gland tumor or neurogenic tumor. Consideration of a malignant salivary gland mass led us to modify our diagnostic approach so as not to risk seeding a potential malignancy and harming the patient. This article also highlights the distinct imaging findings of neurogenic tumors of the neck that are helpful in appropriately diagnosing these tumors.

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Sharma, Sheetal, JignaS Shah, and Harleen Bali. "Malignant peripheral nerve sheath tumor: A rare malignancy." Journal of Oral and Maxillofacial Pathology 24, no. 4 (2020): 86. http://dx.doi.org/10.4103/jomfp.jomfp_9_20.

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Shailee, Mehta, Dabral Ritwika, and Trivedi Priti. "Glomus Tumor of Uncertain Malignant Potential: A Rare Case Report." Journal of Clinical Cases & Reports 3, no. 1 (2020): 14–17. http://dx.doi.org/10.46619/joccr.2020.3-1054.

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Glomus tumor is usually a small, benign tumor and typically occurs in the dermis or subcutis or soft tissues of the extremities and rarely in the visceral locations. Its bronchopulmonary origin is exceedingly rare clinical condition. The current case reported a 51-year-old male with dyspnea on exertion and obstructive pneumonia; he had a glomus tumor which has large size, deep location and exhibits an infiltrative margin as well as atypical mitotic figures. These characteristic suggests malignant behavior. Therefore diagnosis of glomus tumor of uncertain malignant potential was favored. Recent

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Maharjan, O., N. Bajracharya, G. Dangal, et al. "Misleading Diagnosis of Dysgerminoma in a Young Asymptomatic Patient." Kathmandu University Medical Journal 18, no. 4 (2020): 425–27. http://dx.doi.org/10.3126/kumj.v18i4.49411.

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Dysgerminomas account for approximately one third of all malignant ovarian germ cell tumors (tumors arising from ovarian germinal elements) and are the most common ovarian malignancy detected during pregnancy. They are the only germ cell malignancy with a significant rate of bilateral ovarian involvement that is 15-20 percent. They have a variable gross appearance, but in general are solid, pink to tan to cream colored lobulated masses. They have the best prognosis of all malignant ovarian germ cell tumor variants. Two thirds are stage I at diagnosis, and prognosis is excellent even for those

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Shah, Surendra, Jay Nath Shah, Rajesh Nath Gongal, Sameer Shrestha, and Sanjay Poudyal. "Parotid Tumor: A review of seven yearsâ€™ experience." Journal of General Practice and Emergency Medicine of Nepal 3, no. 4 (2014): 42–45. http://dx.doi.org/10.59284/jgpeman141.

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Introduction: Parotid tumors represent about 80% of all salivary gland tumors. Our study was conducted to assess the clinical features, diagnostic accuracy of fine needle aspiration cytology (FNAC), surgical outcome and histological pattern of all patients underwent parotid surgery for parotid tumor at Patan Hospital. Methods: All data of patients who underwent parotid surgery from 2060 to 2067 BC at Patan Hospital were collected retrospectively from medical files and analyzed. Results: Among 18, all were presented with lump in the parotid region. Mean age of the patients was 45 ye

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Khatri, R. "Clinicopathological Analysis of Ovarian Tumours at Birendra Military Hospital." Medical Journal of Shree Birendra Hospital 10, no. 1 (2012): 26–31. http://dx.doi.org/10.3126/mjsbh.v10i1.6446.

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Introduction: Ovarian cancer is the second most common genital tract malignancy accounting for 25% gynaecological malignancy. This study was conducted to determine the incidence, epidemiological factors and clinical presentation of different types of ovarian tumours their correlation with histopathology. Methods: This is a descriptive study conducted in Birendra Military Hospital over a period of 2 years. The case records of all the patients with ovarian tumur was analyzed. Results: Of the total of 135 adnexal masses cases 100 (74.07%) were found to be histologically proven ovarian tumour out

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Boné, B., P. Aspelin, L. Bronge, and B. Veress. "Contrast-enhanced MR imaging as a prognostic indicator of breast cancer." Acta Radiologica 39, no. 3 (1998): 279–84. http://dx.doi.org/10.1080/02841859809172195.

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Background: Using contrast-enhanced MR imaging in the diagnosis of breast cancer may provide additional information not only on tumor extension but also on the biological behavior of tumors. Thus certain characteristics such as tumor angiogenesis and the proliferating activity of the tumor, which have been shown to correlate significantly with prognosis, are both potentially amenable to analysis by MR imaging Material and Methods: We compared contrast enhancement in 50 malignant breast tumors at MR imaging to several prognostic factors, such as tumor size, lymph-node status, histological grade

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Liang, Yuanxin, Robert S. Heller, Julian K. Wu, Carl B. Heilman, Arthur S. Tischler, and Knarik Arkun. "High p16 Expression Is Associated with Malignancy and Shorter Disease-Free Survival Time in Solitary Fibrous Tumor/Hemangiopericytoma." Journal of Neurological Surgery Part B: Skull Base 80, no. 03 (2018): 232–38. http://dx.doi.org/10.1055/s-0038-1669419.

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Objective Solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are now classified along a single spectrum of fibroblastic mesenchymal tumors with NAB2–STAT6 fusion. This fusion acts as a driver mutation that constitutively activates EGR1, which is known to be involved in the p16 pathway. Overexpression of p16 is associated with malignancy and worse prognosis in multiple mesenchymal tumors. The authors sought to investigate p16 immunoexpression in association with malignancy and prognosis of SFT/HPC tumors. Design Twenty-three SFT/HPC tumors (central nervous system [CNS]: 12, non CNS: 11

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Wolf, AM, K. Naylor, and D. Kondziolka. "GP.05 The risk of malignancy after stereotactic radiosurgery." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (2018): S9. http://dx.doi.org/10.1017/cjn.2018.80.

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Background: A major concern of patients undergoing Gamma Knife radiosurgery (GKS) for benign tumors and other conditions is the risk of a separate secondary malignancy or malignant -transformation. The incidence of radiosurgery-associated malignancy based on long-term follow-up remains unknown. Methods: We conducted a population-based cohort study to estimate the incidence rate of both malignant transformation and a separate radiation-associated malignancy in patients undergoing GKS from 1987 to 2016 at 5 centers. Results: 11 527 patients underwent radiosurgery for meningioma (n=3261), arterio

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Zineb, Tazi, Boumaaza Sara, Jayi Sofia, Fdili Alaoui Fatimzehra, Chaara Hikmat, and Melhouf Moulay Abdelilah. "Ovarian masses and pregnancy: About 2 cases and literature review (experience of Gyneco-obstetrics service 2 Fez)." Obstetrics & Gynecology International Journal 15, no. 1 (2024): 25–27. http://dx.doi.org/10.15406/ogij.2024.15.00729.

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Management of adnexal masses during pregnancy can be challenging for the patient and clinician. The specter of a possible malignant tumor may influence the decision to intervene rather than the expected management. The etiologies of ovarian masses vary depending on the age of the parturient, and therefore, benign entities such as functional ovarian cysts, benign cystic teratomas, and serous cystadenomas predominate. In cases of malignancy, these are generally germ cell tumors and borderline, low-grade ovarian tumors. Ultrasound is the primary modality used to detect ovarian masses and assess t

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Staudacher, Nina, Gennadi Tulchiner, Katie Bates, et al. "Organ-Sparing Surgery in Testicular Tumor: Is This the Right Approach for Lesions ≤ 20 mm?" Journal of Clinical Medicine 9, no. 9 (2020): 2911. http://dx.doi.org/10.3390/jcm9092911.

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Background: This study was conducted in order to analyze factors predicting malignancy in patients undergoing organ-sparing surgery (OSS) for small testicular lesions. Methods: Patients with small (≤20 mm) marker-negative clinical stage I testicular tumors were managed by OSS with tumor enucleation and frozen section examination (FSE) for the past 15 years at our institution. Benign and malignant cases were compared, focusing on preoperative and postoperative lesion sizes. Results: Eighty-nine patients were enrolled in this retrospective study. Ten (11.2%) of them were treated for synchronous

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Almigdad, Ahmad Khaled, Bara’ Zaid Dagher, Ola Mohammad Alwaqfi, Mutaz Ahmad Ghabashneh, and Hamzeh Ahmad Alfqaha. "Bone tumors distribution in diagnostic and excisional biopsies." Journal of Musculoskeletal Surgery and Research 5 (June 22, 2021): 159–68. http://dx.doi.org/10.25259/jmsr_49_2021.

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Objectives: Bone tumors are uncommon. Nevertheless, bone is a common site for metastasis. Due to limited data regarding bone tumors in Jordan, this study aims to understand better bone tumor epidemiology and distribution in the Jordanian population. Methods: A part of a retrospective, single-center study, all biopsy reports confirming the diagnosis of a bone tumor between January 2017 and December 2019 were abstracted from Princess Iman Research Center records. The patients’ age, gender, anatomical location, and histopathological type of the tumors were obtained and analyzed. Results: Two hund

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Kawashima, Masatou, Katsumi Doh-ura, Eisuke Mekada, Masashi Fukui, and Toru Iwaki. "CD9 Expression in Solid Non-neuroepithelial Tumors and Infiltrative Astrocytic Tumors." Journal of Histochemistry & Cytochemistry 50, no. 9 (2002): 1195–203. http://dx.doi.org/10.1177/002215540205000906.

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The tetraspan membrane protein CD9 is normally expressed in the mature myelin sheath and is believed to suppress the metastatic potential of certain human tumors. In this study we identified CD9 in a variety of brain tumors by immunohistochemical (IHC) and immunoblotting analyses. We examined 96 tumor samples and three glioma cell lines in addition to a murine brain tumor model of transplanted glioma cells in CD9-deficient mice and control mice. CD9 was expressed not only in solid non-neuroepithelial tumors but also in infiltrative malignant neuroepithelial tumors. Among the neuroepithelial tu

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Hadi, Bayu Antara, and Mouli Edward. "Tumor Mimicking in Musculoskeletal System in Surabaya: A Case Series." Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya 4, no. 1 (2020): 111. http://dx.doi.org/10.30651/jqm.v4i1.2652.

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ABSTRACTMusculoskeletal tumors are potential causes of heavy morbidity and economic burdens for patients. There are often cases suspected as musculoskeletal tumors based on a specific diagnostic modality because of overlapping features upon physical examination or a tumor-like appearance from the radiological examination, the more reason for triple diagnosis to be performed for an exact diagnosis. We report 5 cases of fractures tumor-mimicking lesions. The First patient, a patient with MRI revealing a primary malignant bone tumor, but with plain thorax x-ray and FNAB, the diagnosis was tubercu

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Jeuken, Judith W. M., Sandra H. E. Sprenger, Harry Vermeer, Arnoud C. Kappelle, Rudolf H. Boerman, and Pieter Wesseling. "Chromosomal imbalances in primary oligodendroglial tumors and their recurrences: clues about malignant progression detected using comparative genomic hybridization." Journal of Neurosurgery 96, no. 3 (2002): 559–64. http://dx.doi.org/10.3171/jns.2002.96.3.0559.

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Object. Despite the rapid increase in knowledge concerning the genetic basis of malignant progression in astrocytic tumors, progression of oligodendroglial tumors (including both pure oligodendrogliomas and mixed oligoastrocytomas) is still poorly understood. The aim of the present study is the elucidation of chromosomal imbalances involved in the progression of oligodendroglial tumors toward malignancy. Methods. Using comparative genomic hybridization (CGH) on snap-frozen tumor tissue, the tumor genomes of five primary oligodendroglial tumors and associated recurrent tumors were screened for

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