Relevant bibliographies by topics / Mass spectrometry imaging / Dissertations / Theses
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Dissertations / Theses on the topic 'Mass spectrometry imaging'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Yuen, Wei Hao. "Ion imaging mass spectrometry." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564395.

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This work investigates the applicability of fast detectors to the technique of microscope-mode imaging mass spectrometry. By ionising analyte from a large area of the sample, and projecting the desorbed ions by the use of ion optics through a time-of-flight mass spectrometer onto a two- dimensional detector, time- (and hence mass-) dependent distributions of ions may be imaged. To date, this method of imaging mass spectrometry has been limited by the ability to image only one mass window of interest per experimental cycle, limiting throughput and processing speed. Thus, the alternative micropr
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2

Cobice, Diego Federico. "Mass spectrometry imaging of steroids." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21032.

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Glucocorticoids are steroid hormones involved in the stress response, with a well-established role in promoting cardiovascular risk factors including obesity and diabetes. The focus of glucocorticoid research has shifted from understanding control of blood levels, to understanding the factors that control tissue steroid concentrations available for receptor activation; it is disruption of these tissue-specific factors that has emerged as underpinning pathophysiological mechanisms in cardiovascular risk, and revealed potential therapeutic targets. However, the field is hampered by the inability
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3

Palmer, Andrew D. "Information processing for mass spectrometry imaging." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5472/.

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Mass Spectrometry Imaging (MSI) is a sensitive analytical tool for detecting and spatially localising thousands of ions generated across intact tissue samples. The datasets produced by MSI are large both in the number of measurements collected and the total data volume, which effectively prohibits manual analysis and interpretation. However, these datasets can provide insights into tissue composition and variation, and can help identify markers of health and disease, so the development of computational methods are required to aid their interpretation. To address the challenges of high dimensio
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4

Stryffeler, Rachel Bennett. "New analytical approaches for mass spectrometry imaging." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54892.

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Chemical imaging by mass spectrometry is a powerful approach by which to map spatial distributions of molecules to better understand their function in the system of interest. Over the last thirty years, MSI has evolved into a very powerful analytical tool for the investigation of chemically-complex samples including biological tissues, catalytic surfaces and thin layer chromatography plates, among many others. The work in this dissertation aimed to characterize existing MSI methods, while also developing novel instrumentation able to overcome the challenges found in a variety of applications.
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5

Fornai, L. "Molecular Imaging of the heart by mass spectrometry." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421675.

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BACKGROUND Cardiovascular diseases are the world’s number one death cause, accounting for 17.1 million deaths a year. There is still much unknown about cardiovascular diseases and their physiological underlying mechanism. Understanding the nature of complex biological processes occurring in both healthy and diseased heart tissue requires identifying the compounds involved and determining where they are located. Summary METHODS We have investigated a complementary mass spectrometry imaging (MSI) approach using matrix-assisted laser desorption/ionization (MALDI) and secondary ion mass spe
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6

Jung, Seokwon. "Surface characterization of biomass by imaging mass spectrometry." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45906.

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Lignocellulosic biomass (e.g., non food-based agricultural resides and forestry wastes) has recently been promoted for use as a source of bioethanol instead of food-based materials (e.g., corn and sugar cane), however to fully realize these benefits an improved understanding of lignocellulosic recalcitrance must be developed. The primary goal of this thesis is to gain fundamental knowledge about the surface of the plant cell wall, which is to be integrated into understanding biomass recalcitrance. Imaging mass spectrometry by TOF-SIMS and MALDI-IMS is applied to understand detailed spatial a
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7

Henderson, Fiona. "Mass spectrometry imaging of lipid profiles in disease." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/mass-spectrometry-imaging-of-lipid-profiles-in-disease(f1b202b1-2a6e-416e-ab81-321ef4f0e24d).html.

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It is well established that lipids play an important role in diseases such as non-alcoholic fatty liver disease and cardiovascular diseases. However, in the past decade, it has come to light that lipids may be important in other diseases; particularly in cancer and neurological disorders. Here, lipid metabolism has been investigated using pre-clinical cancer models for melanoma, glioma, non-small-cell lung cancer and colorectal cancer. The role of lipids in the recovery post-stroke has also been studied. Mass spectrometry imaging offers an ideal tool to study lipids in tissue ex-vivo. Lipids i
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8

Guo, Ang. "Improving the performance of microscope mass spectrometry imaging." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:aa94a7f6-00ee-4b56-ba65-f6946799d5f2.

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Mass spectrometry imaging (MSI) is a powerful tool that provides mass-specific surface images with micron or sub-micron spatial resolutions. In a microscope MSI experiment, large sample surfaces are illuminated with a defocused laser or primary ion beam, enabling all surface molecules to be desorbed and ionised simultaneously before being electrostatically projected onto a position-sensitive imaging detector at the end of a time-of-flight mass analyser. Traditionally only the image of one mass-to-charge ratio can be obtained in a single acquisition, which limits its applicability. However, the
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9

Nakata, Yoshihiko. "Imaging Mass Spectrometry with MeV Heavy Ion Beams." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124537.

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10

Hulme, Heather E. "Mass spectrometry imaging to investigate host-microbe interactions." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8930/.

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Mass spectrometry imaging (MSI) is a powerful tool for mapping the spatial distribution and relative abundance of molecules across a sample surface. The distribution of proteins, metabolites, lipids and drugs can be determined and unlike other molecular imaging techniques, such as immunohistochemistry (IHC), MSI is completely label-free. Therefore, this technique does not require prior knowledge of the molecule to be imaged and thousands of molecules can be imaged at once. This is particularly useful for untargeted imaging, to discover molecules which are important for a certain condition. For
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11

Fu, Tingting. "3D and High Sensitivity Micrometric Mass Spectrometry Imaging." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS218/document.

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L'imagerie par spectrométrie de masse est d’un grand intérêt pour aborder les questions biologiques en fournissant simultanément des informations chimiques et spatiales. En particulier, la spectrométrie de masse baptisée TOF-SIMS est bien reconnue par sa haute résolution spatiale (< 1 μm), qui est essentielle pour révéler l'information chimique dans une zone submicronique. L'emploi croissant de cette technique dans la caractérisation des échantillons biologiques a bénéficié du développement de nouvelles sources d'ions d’agrégats. Cependant, les processus d'ionisation/désorption des analytes
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12

DONG, YONGHUI. "Mass spectrometry imaging: looking fruits at molecular level." Doctoral thesis, country:IT, 2014. http://hdl.handle.net/10449/24270.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me
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13

Dong, Yonghui. "Mass Spectrometry Imaging: Looking Fruits at Molecular Level." Doctoral thesis, Università degli studi di Trento, 2014. https://hdl.handle.net/11572/368984.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me
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14

Dong, Yonghui. "Mass Spectrometry Imaging: Looking Fruits at Molecular Level." Doctoral thesis, University of Trento, 2014. http://eprints-phd.biblio.unitn.it/1286/1/Thesis_Yonghui_Dong.pdf.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me
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15

Race, Alan M. "Investigation and interpretation of large mass spectrometry imaging datasets." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6718/.

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Mass spectrometry imaging (MSI) enables two- and three-dimensional overviews of hundreds of unlabelled molecular species including drugs, metabolites, lipids and proteins in complex samples such as intact tissue. In this research, a new extensible software platform is presented, suitable for spectral preprocessing, multivariate analysis and visualisation of large MSI datasets from all major MSI vendors. Principal component analysis (PCA) has been widely used in the unsupervised processing of MSI data. Standard implementations of PCA require the entire dataset to be stored in memory, necessitat
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16

Halford, Edward. "Microscope-mode imaging mass spectrometry with the PImMS camera." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:bf2d51d4-5037-4be4-8e3b-29861f2ae005.

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Until recently, the use of microscope-mode imaging mass spectrometry (MSI) was restricted by the available technology. Fast cameras were limited to acquiring a single image relating to a set m/z range which had to be predefined before the experiment was started. Now, new developments in camera technology have produced time-stamping cameras that can record the arrival time of ions at a detector, without the need to define an exposure time. This allows the images relating to different species with a range of m/z to be acquired simultaneously. One of these cameras is the Pixel Imaging Mass Spectr
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17

Lum, Tsz Shan. "Elemental imaging and speciation for bioanalysis." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/328.

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Elemental detection is an emerging area in bioanalysis. Thanks to the rapid advancement in instrumentation such as inductively coupled plasma-mass spectrometry (ICP-MS), low detection limit and quick analysis can be achieved. Besides, ICP-MS also suffers less matrix effect as compared to molecular mass spectrometry, so a precise and accurate detection of toxic or essential elements can be provided. Different types of sample introduction or separation systems such as laser ablation (LA) and liquid chromatograph (LC) are excellent hyphenation options for the elemental detection apart from the to
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18

Herman, Stephanie. "Automatic detection of protein degradation markers in mass spectrometry imaging." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275072.

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Today we are collecting a large amount of tissue samples to store for future studies of different health conditions, in hopes that the focus in health care will shift from treatments to early detection and prevention, by the use of biomarkers. To make sure that the storing of tissue is done in a reliable way, where the molecular profile of the samples are preserved, we first need to characterise how these changes occur. In this thesis, data from mice brains were collected using MALDI imaging mass spectrometry (IMS) and an analysis pipeline for robust MALDI IMS data handling and evaluation was
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19

Hamilton, Jason S. "Disease Tissue Imaging and Single Cell Analysis with Mass Spectrometry." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984137/.

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Cells have been found to have an inherent heterogeneity that has led to an increase in the development of single-cell analysis methods to characterize the extent of heterogeneity that can be found in seemingly identical cells. With an understanding of normal cellular variability, the identification of disease induced cellular changes, known as biomarkers, may become more apparent and readily detectable. Biomarker discovery in single-cells is challenging and needs to focus on molecules that are abundant in cells. Lipids are widely abundant in cells and play active roles in cellular signaling
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20

Dhunna, Manan. "Desorption Electrospray Ionization Mass Spectrometry Imaging: Instrumentation, Optimization and Capabilities." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/3969.

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Desorption Electrospray Ionization Mass spectrometry Imaging (DESI-MSI) is an area of great interest and a promising tool in the field of chemical imaging. It is a powerful, label-free technique, which can determine, map and visualize different molecular compounds on a sample surface. The amount of information acquired in a single DESI-MSI experiment is enormous compared to other techniques, as it can simultaneously detect different compounds with their spatial distribution on the surface. The experiment can be used to produce two-dimensional and three-dimensional images. Chapter 2 focuses on
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21

Atkinson, Sally Jayne. "Fundamental aspects of imaging matrix assisted laser desorption/ionisation mass spectrometry." Thesis, Sheffield Hallam University, 2008. http://shura.shu.ac.uk/19293/.

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Matrix assisted laser desorption/ionisation mass spectrometry imaging is a recent addition to the existing family of molecular imaging technologies. It has the capacity to map the distribution of molecules within a biological tissue section, without the need for radionuclide or fluorescent labelling procedures. The primary aim of the work presented in this thesis was to assess the use of a high repetition rate laser for MALDI-MS image analysis by developing methodologies for the detection of a number of different compounds from a variety of biological tissues. Additional investigations include
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22

Tang, Ho-wai, and 鄧浩維. "Studies on surface-assisted laser desorption/ionization and its analytical application in imaging mass spectrometry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47145559.

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Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) is an analytical technique enabling direct chemical analysis of solid samples. Analytes could be desorbed/ionized upon nitrogen laser irradiation from a SALDI substrate-coated sample, then analyzed by MS. The substrate is involved in the transfer of laser energy to the analytes, and eventually assists the desorption/ionization of analytes. The analytical performance of SALDI-MS, such as detection sensitivity, is dependent on different parameters of the substrate, such as size, morphology and form. In this thesis, the ef
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23

Balluff, Benjamin. "MALDI imaging mass spectrometry in clinical proteomics research of gastric cancer tissues." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155986.

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24

Winter, Benjamin. "Novel methods in imaging mass spectrometry and ion time-of-flight detection." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:43db5039-0490-4f97-8519-4d3ed4e30ca3.

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Imaging mass spectrometry (IMS) in microscope mode allows the spatially resolved molecular constitution of a large sample section to be analysed in a single experiment. If performed in a linear mass spectrometer, the applicability of microscope IMS is limited by a number of factors: the low mass resolving power of the employed ion optics; the time resolution afforded by the scintillator screen based particle detector and the multi-hit capability, per pixel, of the employed imaging sensor. To overcome these limitations, this thesis concerns the construction of an advanced ion optic employing a
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25

Djidja, Marie-Claude. "Examination of tumour tissues by direct MALDI-mass spectrometry imaging and profiling." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20662/.

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The purpose of the work described in this thesis was to develop and apply efficient methodologies based on MALDI-MSI for the direct analysis and targeting of protein tumour biomarkers within both frozen and formalin fixed paraffin embedded (FFPE) cancerous tissue sections. Method development for protein analysis directly in tumour tissue sections were performed using tumour xenograft models. This involved improvements in sample preparation, such as tissue washing protocols, and the development of data pre-processing methods prior to statistical analysis using a freely available software packag
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26

Endres, Kevin J. "Mass Spectrometry Methods For Macromolecules: Polymer Architectures, Cross-Linking, and Surface Imaging." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1553096604194835.

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27

Velarde, Luis Antonio. "Photoinitiated Dynamics of Cluster Anions via Photoelectron Imaging and Photofragment Mass Spectrometry." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195042.

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Mass-selected cluster anions are employed as model micro-solutions to study solvent effects on the structural motifs and electronic structure of anionic solutes, including the roles of the solvent in controlling the outcomes of photochemical processes. Interaction of light with cluster anions can potentially lead to cluster photodissociation in addition to photodetachment. We investigate these competing processes by means of photoelectron imaging spectroscopy combined with tandem time-of-flight (TOF) mass spectrometry. Photoelectron images are reported for members of the [(CO2)n(H2O)m]- cluste
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28

DENTI, VANNA. "Development of multi-omic mass spectrometry imaging approaches to assist clinical investigations." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365169.

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Con il termine di –omica spaziale si intende l’insieme di diverse tecniche che consentono di rilevare alterazioni significative delle biomolecole all’interno dei loro tessuti d’origine o delle strutture cellulari, permettendo quindi di integrare ed ampliare la comprensione dei cambiamenti biologici che si verificano in tessuti patologici complessi ed eterogenei, come il cancro. Tuttavia, per comprendere appieno la complessità e le dinamiche al di là delle condizioni patologiche, è necessario studiare e integrare diverse analisi molecolari, come quelle di lipidi e glicani, in modo da ottenere u
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29

Asogan, Dhinesh. "A non-contact laser ablation cell for mass spectrometry." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/11014.

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A common analytical problem in applying LA sampling concerns dealing with large planar samples, e.g. gel plates, Si wafers, tissue sections or geological samples. As the current state of the art stands, there are two solutions to this problem: either sub-sample the substrate or build a custom cell. Both have their inherent drawbacks. With sub-sampling, the main issue is to ensure that a representative is sample taken to correctly determine the analytes of interest. Constructing custom cells can be time consuming, even for research groups that are experienced or skilled, as they have to be vali
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30

Xu, Yang. "Multimodal Spectral Microscopy and Imaging Mass Spectrometry of Biomolecules in Cells and Tissues." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1333769758.

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31

Olivero, Daniel. "Traumatic brain injury biomarker discovery using mass spectrometry imaging of 3D neural cultures." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41102.

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Biomarker research is of great interest in the field of traumatic brain injury (TBI), since there are numerous potential markers that may indicate central nervous system damage, yet the brain is normally well isolated and discovery is at its infancy. Traditional methods for biomarker discovery include time consuming multi step chromatographic mass spectrometery (MS) techniques or pre-defined serial probing using traditional assays, making the identification of biomarker panels limiting and expensive. These shortfalls have motivated the development of a MS based probe that can be embedded into
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32

Rowland, Tyson G. "Accurate ionic bond energy measurements with TCID mass spectrometry and imaging PEPICO spectroscopy." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/809.

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Two projects are presented here. In the first, metal-cyclopentadienyl bond dissociation energies (BDEs) were measured for seven metallocene ions (Cp2M+, Cp = η5-cyclopentadienyl = c-C5H5, M = Ti, V, Cr, Mn, Fe, Co, Ni) using threshold collision-induced dissociation (TCID) performed in a guided ion beam tandem mass spectrometer. For all seven room temperature metallocene ions, the dominant dissociation pathway was simple Cp loss from the metal. Traces of other fragment ions were also detected, such as C10H10+, C10H8+, C8H8+, C3H3+, H2M+, C3H3M+, C6H6M+, and C7H6M+, depending on the metal center
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33

Aboulmagd, Khodier Sarah. "Analysis of Lipids in Kidney Tissue Using High Resolution MALDI Mass Spectrometry Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19443.

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Massenspektrometrisches Imaging (MSI) ist unverzichtbar für die Untersuchung der räumlichen Verteilung von Molekülen in einer Vielzahl von biologischen Proben. Seit seiner Einführung hat sich MALDI zu einer dominierenden Bildgebungsmethode entwickelt, die sich als nützlich erwiesen hat, um die Komplexität von Lipidstrukturen in biologischen Geweben zu bestimmen. Einerseits ist die Rolle von Cisplatin bei der Behandlung von menschlichen malignen Erkrankungen gut etabliert, jedoch ist Nephrotoxizität eine limitierende Nebenwirkung, die Veränderungen des renalen Lipidprofils beinhaltet. Dies füh
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PIGA, ISABELLA. "Proteomics tools and mass spectrometry imaging techniques for the molecular characterization of pancreas." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1007351.

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The pancreas is a large glandular organ with mixed exocrine and endocrine functions, located in the abdominal cavity behind the stomach. The endocrine portion, 1-2 % of its total volume, is represented by islets of Langerhans and plays a significant role in the pathophysiology of diabetes. The islets mainly contain β cells, which produce and release the hormonal protein insulin into the bloodstream in order to reduce glucose concentrations in the blood [1]. Dysfunction of this regulatory mechanism can lead to the development of type 2 diabetes mellitus (T2DM), a chronic metabolic disorder char
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35

Lagache, Laurine. "Visualizing the molecular interaction networklevel heterogeneity of malignant tumors by mass spectrometry imaging." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS111.pdf.

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Le cancer est la deuxième cause de décès dans le monde, avec 10 millions de morts et 19 millions de nouveaux cas en 2020. Le cancer du sein, le plus fréquent chez les femmes, comptait 2,26 millions de cas et près de 685 000 décès cette même année, soulignant l'urgence de recherches ciblées. Le diagnostic repose souvent sur des biopsies analysées histopathologiquement pour identifier les caractéristiques moléculaires des cellules cancéreuses. En fonction de l'expression de certains biomarqueurs (récepteurs hormonaux, oncoprotéines, récepteurs de facteurs de croissance), les sous-types de cancer
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36

Berrueta, Razo Irma. "Molecular imaging of mouse brain tissue using Cluster Time-of-Flight Secondary Ion Mass Spectrometry." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/molecular-imaging-of-mouse-brain-tissue-using-cluster-timeofflight-secondary-ion-mass-spectrometry(a350dc50-5337-4d32-a95c-24c617bbba97).html.

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ToF-SIMS imaging has been drawing attention due to the wide range of applications in the biological and biomedical fields. These applications include the acquisition of quantitative and qualitative data that ranges in scale from single cells to organs, image visualisation and interpretation of biomarkers for diagnosis and development of pharmaceutics. This study focused on molecular imaging of mouse brain tissue sections using cluster primary ion beams. First, cluster ion beams were applied to comparative background studies of biomolecules and brain total lipid extract. Enhancement of the seco
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37

Villacob, Raul A. "Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2561.

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Secondary Ion Mass Spectrometry (SIMS) is a powerful technique for high spatial resolution chemical mapping and characterization of native surfaces. The use of massive cluster projectiles has been shown to extend the applicable mass range of SIMS and improve secondary ion yields 100 fold or beyond. These large projectiles however, present a challenge in terms of focusing due to the initial spatial and kinetic energy spreads inherent to their generation. In the present work, we describe the development and construction of a novel primary ion (PI) column employing a gold nanoparticle – liquid me
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Tuck, Michael. "Molecular characterization of tuberculosis by MALDI mass spectrometry - applications toward multi-omic and multimodal imaging." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0015.

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Cette thèse vise à relever le défi sanitaire urgent de la tuberculose (TB) par le développement d'une stratégie d'imagerie par spectrométrie de masse quantitative ou QMSI, en se concentrant spécifiquement sur les médicaments antiTB tels que la clofazimine (CFZ), la rifampicine (RIF), et l'éthambutol (ETM). TB, causée par Mycobacterium tuberculosis (Mtb), constitue une menace pour la santé mondiale, également renforcée par la résistance bactérienne, induisant la mise en place de lignes de thérapie basées sur l'utilisation d'un traitement adapté et plus efficace avec un panel d'antibiotiques épr
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39

Sui, Ping. "Molecular Signatures of Neuropathic Pain : Revealing Pain-Related Signaling Processes in Spinal Cord Using Mass Spectrometric Methodologies." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251334.

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In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. The estimated prevalence of NP is 6-8% in general population. Only in the United States, the indirect cost associated with chronic pain has been estimated to 100 billion dollars each year and NP substantially contributes to this cost. So far, the underlying
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40

Liu, Qiang. "Fundamental Study and Method Development for Surface-based Laser Desorption Ionization Imaging Mass Spectrometry." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-02262009-143514/.

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By providing both the chemical identity and the spatial organization of each component in biological samples, Imaging Mass Spectrometry (IMS) becomes an emerging tool in clinic and pharmacological study. Most work in IMS has been focused on protein and peptide mapping in biological samples to take advantage of effective analyte ionization in MALDI-MS, and also partially due to the limitation of MALDI-MS in small molecule detection. The focus of my research is to develop novel tools to image spatial distribution of small molecules in biological samples. A surface-based mass spectrometric imagin
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41

Rodrigues, Lívia Riberti 1988. "Análise de impurezas de formas farmacêuticas sólidas por MALDI Mass Spectrometry Imaging (MALDI-MSI)." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312437.

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Orientador: Rodrigo Ramos Catharino<br>Texto em português e inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T05:33:49Z (GMT). No. of bitstreams: 1 Rodrigues_LiviaRiberti_M.pdf: 1203619 bytes, checksum: a17baf81fa013532bd6c9d451b2336f2 (MD5) Previous issue date: 2014<br>Resumo: Atualmente, as doenças cardiovasculares constituem uma das primeiras causas de mortes no Brasil e no mundo. Neste cenário, as estatinas constituem uma notável classe de medicamentos redutores de colesterol e têm sido associadas
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Gorishek, Emma Lee. "Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Raman Spectroscopy Imaging of Biological Tissues." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc849725/.

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Laser Ablation Inductively coupled plasma mass spectrometry (LA-ICP-MS) and Raman spectroscopy are both powerful imaging techniques. Their applications are numerous and extremely potential in the field of biology. In order to improve upon LA-ICP-MS an in-house built cold cell was developed and its effectiveness studied by imaging Brassica napus seeds. To further apply LA-ICP-MS and Raman imaging to the field of entomology a prong gilled mayfly (Ephemeroptera: Leptophlebiidae) from the Róbalo River, located on Navarino Island in Chile, was studied. Analysis of both samples showcased LA-ICP-MS a
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Garrett, Timothy J. "Imaging small molecules in tissue by matrix-assisted laser desorption/ionization tandem mass spectrometry." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013807.

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Dooley, Patrick W. Corkum Paul B. "Molecular imaging using femtosecond laser pulses." *McMaster only, 2003.

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45

Chiasson, Martin. "An Imaging Mass Spectrometer with Ultrashort Laser Pulses as its Ionization Source." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34343.

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We have built an imaging mass spectrometer adapted for ultrashort laser pulses as its ionization technique, as an alternative to other imaging techniques. Before my arrival, the mass spectrometer has only been subject to preliminary tests on noble gases. Since then, we’ve made some modifications to the system in order to properly analyze solids. This thesis shows how we obtain our ultrashort laser pulses, the inner workings of our homemade imaging mass spectrometer, and the results that we’ve obtained with it so far. We tested two modes of operation concerning the extraction of the ions from t
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IVANOVA, MARIIA. "Advanced proteomics MALDI-MSI imaging in chronic glomerulonephrites: from diagnostics to precision medicine." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263391.

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Chronical kidney disease (CKD) is a worldwide health problem with increasing incidence, where the major part accounts for chronic glomerulonephrites (GN). It is a group of diseases of various aetiology and multiform clinical course, having various prognosis which is often hardly predictable as well as existing prognostic markers are not always certain. There is an urging need of new reliable and specific prognostic and therapeutic markers research. A modern proteomic technology - Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been employed in many GN stud
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Nilsson, Anna. "Molecular Profiling and Imaging of Peptides, Proteins and Drugs in Biological Tissue using Mass Spectrometry." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9337.

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Biological functions within cells and organisms are mainly carried out by the translational products; proteins and peptides. The analysis and characterization of these biomolecules are of great importance for the progress in disease research and biomarker and drug discovery. The term peptidomics was introduced to describe the comprehensive analysis of peptides (e.g. neuropeptides) in biological tissues. In this thesis, a peptidomics approach using nanoflow liquid chromatography coupled to electrospray mass spectrometry (MS) has been developed for detection, identification, and quantification o
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Jiang, Haibo. "Exploiting stable isotope imaging with high resolution secondary ion mass spectrometry for applications in biology." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:15456362-6022-41e1-b78d-1127d6d172b0.

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This thesis presents applications of high resolution secondary ion mass spectrometry (NanoSIMS) analysis for stable isotope imaging in biological samples. These projects were designed to explore the potential applications of NanoSIMS analysis, and to develop protocols and novel methodologies to visualize and quantify biological processes. Working with collaborators in the UK and USA, I have applied NanoSIMS analysis to study 3 research areas, including molecule interactions, single cell metabolisms and lipid imaging in tissues. Antimicrobial peptides (AMPs) play important role in the immune sy
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Kawashima, Masahiro. "High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer." Kyoto University, 2014. http://hdl.handle.net/2433/188666.

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Van, Nuffel Sebastiaan. "Three-dimensional time-of-flight secondary ion mass spectrometry imaging of primary neuronal cell cultures." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39644/.

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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) has proven its ability to characterise (in)organic surfaces, and is increasingly used for the characterisation of biological samples such as single cells. By combining ion imaging and molecular depth profiling it is possible to render 3D chemical images, which provides a novel, label-free way to investigate biological systems. Major challenges lie, however, in the development of data analysis tools and protocols that preserve the cell morphology. Here, we develop and employ such tools and protocols for the investigation of neuronal netw
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