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Journal articles on the topic 'Mdr of mycobacterium tuberculosis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Zodape, G. V., S. N. Dharmashale, and V. S. Gaikwad. "Effect of Piper nigrum (Linn.) seeds extract and second line anti-tuberculosis drugs on a few Mycobacterium tuberculosis strains." Journal of Applied and Natural Science 13, no. 1 (2021): 402–6. http://dx.doi.org/10.31018/jans.v13i1.2497.

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Piper nigrum (Linn.) belonging to the family Piperaceae have been reported for its multitudinous medicinal values. The present study was undertaken to examine the direct effect of Ethionamide (ETH), Para amino salicylic acid (PAS), ethanolic extracts of P. nigrum on Mycobacterium tuberculosis (MTB) strain H37Rv and Multi drug-resistant (MDR)-strains-12, 19 and 21. The proportion method was used to detect the anti-mycobacterial drug susceptibility testing for mycobacteria using Lowenstein Jensen (LJ) medium. It was found that P. nigrum does not interfere with single or in the combination of bot

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Pratiwi, Ritha, Gemini Alam, Herlina Rante, and Nasrum Massi. "Aktivitas Anti Mycobacterium tuberculosis Strain H37Rv dan MDR (Multi Drug Resistant) dari Ekstrak Rimpang Curcuma mangga Val." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 6, no. 1 (2020): 70–76. http://dx.doi.org/10.22487/j24428744.2020.v6.i1.13102.

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TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug. The objective of the research is to determine the ability of hexane and methanol extracts of Curcuma mangga in inhibiting the growth of Mycobacterium tuberculosis Strain H37Rv and MDR. The extraction of Curcuma mangga rhizome was conducted by maceration methode using hexane and methanol as the solvents, respectively. Both of extracts were made in 10

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Dey, Rishita, Sisir Nandi, Asmita Samadder, Aaruni Saxena, and Anil Kumar Saxena. "Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation Based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets." Current Topics in Medicinal Chemistry 20, no. 29 (2020): 2662–80. http://dx.doi.org/10.2174/1568026620666200903163921.

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Tuberculosis (TB) is a devastating disease responsible for millions of humans’ deaths worldwide. It is caused by a mycobacterial organism, the tubercle bacillus or Mycobacterium tuberculosis. Although TB can be treated, cured and can be prevented if patients take prescribed medicines, scientists have never come close to wiping it out due to a sharp rise in the incidence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) mycobacterium strains. Due to long regimen treatment and emergence of MDR and XDR-TB, it is urgent to re-engineer and reposition old drugs for developing new ant

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Espinosa-Pereiro, Juan, Adrian Sánchez-Montalvá, Maria Luisa Aznar, and Maria Espiau. "MDR Tuberculosis Treatment." Medicina 58, no. 2 (2022): 188. http://dx.doi.org/10.3390/medicina58020188.

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Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising pharmacological advances in the paradigm of MDR TB treatment: new and repurposed drugs have shown excellent bactericidal and sterilizing activity against Mycobacterium tuberculosis and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the most important drugs currently used to treat MDR TB, the re

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M, Menaka. "Assessment Of Antitubercular Activity Of Serankottai Nei: A Siddha Formulation Against Multidrug-Resistant Mycobacterium tuberculosis." African Journal of Biological Sciences 6, no. 2 (2024): 1353–58. http://dx.doi.org/10.48047/afjbs.6.2.2024.1353-1358.

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Multidrug-resistant Tuberculosis (MDR-TB), caused by Mycobacterium tuberculosis strains resistant to at least two key anti-mycobacterial drugs, is an escalating global health concern. This necessitates the exploration of alternative therapeutic options. The Siddha system of medicine offers a variety of formulations with potential efficacy against severe infections such as TB. This study investigates the effectiveness of Serankottai nei, a Siddha medicinal formulation, against MDR-TB. Different concentrations of Serankottai nei (2%, 4%, and 6%) were evaluated in vitro for their anti-mycobacteri

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Hosseiniporgham, Sepideh, and Leonardo A. Sechi. "A Review on Mycobacteriophages: From Classification to Applications." Pathogens 11, no. 7 (2022): 777. http://dx.doi.org/10.3390/pathogens11070777.

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Mycobacterial infections are a group of life-threatening conditions triggered by fast- or slow-growing mycobacteria. Some mycobacteria, such as Mycobacterium tuberculosis, promote the deaths of millions of lives throughout the world annually. The control of mycobacterial infections is influenced by the challenges faced in the diagnosis of these bacteria and the capability of these pathogens to develop resistance against common antibiotics. Detection of mycobacterial infections is always demanding due to the intracellular nature of these pathogens that, along with the lipid-enriched structure o

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Wulandari, Citra, and Ziske Maritska. "DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE." Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya 9, no. 1 (2022): 117–22. http://dx.doi.org/10.32539/jkk.v9i1.16554.

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Drug-resistant tuberculosis is a public health concern. TB that is drug-resistant to rifampin and isoniazid is known as MDR-TB, whereas XDR-TB is MDR-TB that is also resistant to second-line medicines, such as fluoroquinolones (levofloxacin, ofloxacin, and moxifloxacin). rifampin-resistant tuberculosis (RR-TB), of which 78 percent had multidrug-resistant tuberculosis (MDR-TB) (MDR-TB). Fluoroquinolones are a class of broad-spectrum antimicrobials that have become increasingly popular in recent years. Fluoroquinolones have activity against Mycobacterium tuberculosis both in vitro and in vivo. F

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Diriba, Getu, Abebaw Kebede, Habteyes Hailu Tola, et al. "Mycobacterial Lineages Associated with Drug Resistance in Patients with Extrapulmonary Tuberculosis in Addis Ababa, Ethiopia." Tuberculosis Research and Treatment 2021 (September 18, 2021): 1–7. http://dx.doi.org/10.1155/2021/5239529.

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Background. In Ethiopia, tuberculosis (TB) is one of the most common causes of illness and death. However, there is limited information available on lineages associated with drug resistance among extrapulmonary tuberculosis patients in Ethiopia. In this study, researchers looked into Mycobacterium tuberculosis lineages linked to drug resistance in patients with extrapulmonary tuberculosis in Addis Ababa, Ethiopia. Methods. On 151 Mycobacterium tuberculosis isolates, a cross-sectional analysis was performed. Spoligotyping was used to characterize mycobacterial lineages, while a phenotypic drug

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Raja Iqbal Mulya Harahap, Juandika Juandika, and Dety Mulyanti. "PERBANDINGAN BIAYA PEMERIKSAAN LABORATORIUM PADA PASIEN TUBERKULOSIS MULTIDRUG RESISTANCE (TB-MDR) DENGAN TUBERKULOSIS EXTENSIVE DRUG RESISTANCE (TB-XDR): STUDI PADA RUMAH SAKIT TERSIER DI BANDUNG." DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan 1, no. 1 (2023): 01–09. http://dx.doi.org/10.59581/diagnosa-widyakarya.v1i1.156.

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Introduction. Tuberculosis (TB) is one of the oldest diseases known to attack humans, caused by the bacterium Mycobacterium tuberculosis. Multi-drug-resistant TB (MDR-TB) is a stage or condition in which Mycobacterium tuberculosis becomes minimally resistant to rifampicin administration and also insonicotinylhydrazine (INH). Extensive-drug-resistant TB (XDR-TB) is an MDR-TB with Mycobacterium tuberculosis immune characteristics against one of the fluoroquinolone class drugs and one of the second-line injection OAT (capreomycin, kanamycin, and amikacin). The aim of this study was to find out th

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Kaur, Harveen, Dilbag Singh, Amritpal Kaur, N. C. Kajal, and Mukul Sharma. "Central nervous system Tuberculomas in a patient with disseminated multi-drug resistant tuberculosis; A case report." International Journal of Current Research in Medical Sciences 7, no. 1 (2021): 1–5. http://dx.doi.org/10.22192/ijcrms.2021.07.01.001.

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Tuberculosis (TB) is one of the leading causes of death worldwide, particularly in low- and middle-income countries. Although Mycobacterium tuberculosis can involve any organ, most commonly the lung, central nervous system (CNS) tuberculosis is the most devastating form of the disease. Tuberculoma is the most common parenchymal lesion in CNS tuberculosis which could be found in any portion of the intracranial space. The global rates and numbers of drug resistant TB are rising. With increasing globalization, the spread of drug-resistant strains of TB has become a mounting global public health c

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Andreevskaya, S. N., E. E. Larionova, E. A. Kiseleva, L. N. Chernousova, and A. Е. Ergeshov. "Comparative Molecular Genetic Characteristics of <i>Mycobacterium tuberculosis</i> Cultures Isolated in the European Part of the Russian Federation in 1998–2003 and 2016–2021." Tuberculosis and Lung Diseases 101, no. 3 (2023): 27–36. http://dx.doi.org/10.58838/2075-1230-2023-101-3-27-36.

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The objective: to evaluate changes in detection frequency of Mycobacterium tuberculosis of the main phylogenetic lines with various genetic determinants of resistance to rifampicin, isoniazid and fluoroquinolones in 1998–2003 and 2016–2021.Subjects and Methods. 965 mycobacterial cultures were studied, those cultures were isolated from pulmonary tuberculosis patients in 1998–2003 and 2016–2021. The spoligotypes of isolated Mycobacterium tuberculosis cultures and presence of gene mutations associated with resistance to isoniazid, rifampicin, and fluoroquinolones were determined.Results. In 2016–

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Li, Yingying, Yifan Li, Tingting Wang, et al. "Multidrug-resistant Mycobacterium tuberculosis transmission in Shandong, China." Medicine 103, no. 12 (2024): e37617. http://dx.doi.org/10.1097/md.0000000000037617.

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Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrospective study of patients diagnosed with pulmonary tuberculosis in Shandong from 2009 to 2018 was conducted. To explore transmission patterns, we performed whole genome sequencing on MDR-TB isolates, identified genomic clusters, and assessed the drug resistance of TB isolates. Our study analyzed 167 isolates of MDR-TB, finding that 100 were clustered. The pred

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Istaufa, Fikriaddin Syafiq, Yoyok Subagio, Irma Suswati, and Isbandiyah. "Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis." Folia Medica Indonesiana 58, no. 4 (2022): 371–76. http://dx.doi.org/10.20473/fmi.v58i4.29307.

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Highlight : Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015. Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria. Abstract: Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosi

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14

Tuladhar, Pranita, Dhruba Kumar Khadka, Megha Raj Banjara, and Reshma Tuladhar. "Second Line Drugs Resistant Mycobacterium Tuberculosis in Multi-Drug Resistant Tuberculosis Patients." Journal of Institute of Science and Technology 22, no. 2 (2018): 168–74. http://dx.doi.org/10.3126/jist.v22i2.19609.

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With an increase in Multi-drug resistant tuberculosis (MDR-TB), there is a need of second line drug susceptibility test that helps in early diagnosis and minimize the risk of other powerful drug resistant Mycobacterium tuberculosis. The aim of this study was to determine second line drugs (ofloxacin, kanamycin, capreomycin) resistance pattern in MDR-TB isolates and to determine the prevalence of pre-Extensively drug resistant tuberculosis (pre-XDR-TB) and XDR-TB in MDR-TB patients. The study was conducted from February to September 2015 at National Tuberculosis Centre, Thimi, Bhaktapur. MDR-TB

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15

Lumb, Richard, Ivan Bastian, Chris Gilpin, et al. "Tuberculosis in Australia: bacteriologically confirmed cases and drug resistance, 2006: A report of the Australian Mycobacterium Reference Laboratory Network." Communicable Diseases Intelligence 32 (March 1, 2008): 12–17. https://doi.org/10.33321/cdi.2008.32.2.

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In 2006, the Australian Mycobacterium Reference Laboratory Network identified 905 bacteriologically confirmed cases of disease caused by members of the Mycobacterium tuberculosis complex. The annual reporting rate was 4.4 cases per 100,000 population. Of the 905 isolates, 903 were Mycobacterium tuberculosis and two were Mycobacterium bovis. Fourteen children aged under 10 years (male n=5, female n=9) had bacteriologically confirmed tuberculosis. A total of 100 (11.1%) isolates of M. tuberculosis were resistant to at least one first-line anti-tuberculosis agent. Resistance to at least H and R (

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Maharjan, Elina, Narayan Dutt Pant, Sanjeev Neupane, Jyoti Amatya, and Bhawana Shrestha. "Use of Genotype MTBDRplus Assay for Diagnosis of Multidrug-Resistant Tuberculosis in Nepal." International Scholarly Research Notices 2017 (August 13, 2017): 1–5. http://dx.doi.org/10.1155/2017/1635780.

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The main aims of this study were to study the patterns of mutations in rpoB, katG, and inhA genes in Mycobacterium tuberculosis strains isolated from patients from Nepal and to evaluate the performance of genotype MTBDRplus assay, taking conventional drug susceptibility testing as gold standard for diagnosis of MDR-TB. A total of 69 Mycobacterium tuberculosis strains isolated from 73 smear positive sputum samples from patients suspected of suffering from multidrug-resistant tuberculosis were used in our study. The drug susceptibility pattern of Mycobacterium tuberculosis isolated from these sp

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Iqbal, Azhar, Muhammad Shafique, Muhammad Asif Zahoor, et al. "The occurrence of multidrug-resistant Mycobacterium tuberculosis from patients of pulmonary tuberculosis." Journal of Infection in Developing Countries 16, no. 04 (2022): 698–704. http://dx.doi.org/10.3855/jidc.14990.

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Introduction: Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is one of the leading causes of death in the world. The resource constraints make it difficult to diagnose and monitor the cases of MDR-TB. GeneXpert is a recognized tool used to diagnose the patients of pulmonary tuberculosis in clinical settings across the globe. Methodology: The present one-year cross-sectional study was conducted to estimate the occurrence of MDR-TB in patients with pulmonary TB. A total of 1000 patients suspected of pulmonary tuberculosis were included in this study. A random convenient sampling t

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Luo, Tao, Ming Zhao, Xia Li, et al. "Selection of Mutations To Detect Multidrug-Resistant Mycobacterium tuberculosis Strains in Shanghai, China." Antimicrobial Agents and Chemotherapy 54, no. 3 (2009): 1075–81. http://dx.doi.org/10.1128/aac.00964-09.

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ABSTRACT Novel tools are urgently needed for the rapid, reliable detection of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. To develop such tools, we need information about the frequency and distribution of the mycobacterial mutations and genotypes that are associated with phenotypic drug resistance. In a population-based study, we sequenced specific genes of M. tuberculosis that were associated with resistance to rifampin and isoniazid in 242 phenotypically MDR isolates and 50 phenotypically pan-susceptible isolates from tuberculosis (TB

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Shen, Xin, Guo-miao Shen, Jie Wu, et al. "Association between embB Codon 306 Mutations and Drug Resistance in Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 51, no. 7 (2007): 2618–20. http://dx.doi.org/10.1128/aac.01516-06.

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ABSTRACT embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

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Sadhu, Soumok, Tamoghna Karmakar, Anindya Gopal Chatterjee, et al. "Determination of the antagonistic efficacy of silver nanoparticles against two major strains of Mycobacterium tuberculosis." International Journal of Experimental Research and Review 29 (December 30, 2022): 67–72. http://dx.doi.org/10.52756/ijerr.2022.v29.007.

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Tuberculosis (TB) is considered one of the most prominent diseases across the globe. This present study aims to inspect the impact of silver nanoparticles (AgNP) against Mycobacterium tuberculosis, which is the causative vector of TB. The efficacy of the AgNP was conducted based on the minimum inhibitory concentration (MIC) of the AgNPs through microplate Alamar blue assay. The preparation of the AgNPs involved chemical synthesis. The state and the size of the AgNPs were determined and confirmed by using ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray diffraction (XRD) spectroscopy

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Aliya Rifani, Cynthia Irene Zhu, and M. Revo Artmando Lindani. "Analisis Molekuler Resistensi terhadap Pasien dengan Multidrug Resistance Tuberculosis (MDR TB)." Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran 2, no. 3 (2024): 49–55. http://dx.doi.org/10.55606/termometer.v2i3.3922.

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Mycobacterium tuberculosis is a bacterium that causes tuberculosis disease, which in the healing process requires a long time because this bacterium has a resting phase or what is called a dormant phase. This is one of the factors that cause patients who are undergoing tuberculosis treatment to experience saturation and stop treatment before the specified time. Resistance to antituberculosis drugs is a result of negligence in treatment so that bacteria become resistant to several types of antituberculosis drugs called multidrug resistance tuberculosis (MDR TB). This systematic review aims to e

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Maslov, Dmitry A., Kirill V. Shur, Aleksey A. Vatlin, and Valery N. Danilenko. "MmpS5-MmpL5 Transporters Provide Mycobacterium smegmatis Resistance to imidazo[1,2-b][1,2,4,5]tetrazines." Pathogens 9, no. 3 (2020): 166. http://dx.doi.org/10.3390/pathogens9030166.

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The emergence and spread of drug-resistant Mycobacterium tuberculosis strains (including MDR, XDR, and TDR) force scientists worldwide to search for new anti-tuberculosis drugs. We have previously reported a number of imidazo[1,2-b][1,2,4,5]tetrazines – putative inhibitors of mycobacterial eukaryotic-type serine-threonine protein-kinases, active against M. tuberculosis. Whole genomic sequences of spontaneous drug-resistant M. smegmatis mutants revealed four genes possibly involved in imidazo[1,2-b][1,2,4,5]tetrazines resistance; however, the exact mechanism of resistance remain unknown. We use

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Zorkaltseva, E. Yu, O. A. Vorobyeva, E. D. Savilov, and O. B. Ogarkov. "Multi-Drug Resistance of Mycobacterium Tuberculosis – the Problem of Modern Phthisiology." Acta Biomedica Scientifica 4, no. 2 (2019): 55–59. http://dx.doi.org/10.29413/abs.2019-4.2.8.

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The 21st century is characterized by the exacerbation of the problem formation and spreading of drug-resistant strains throughout the world. Genetic mutations of Mycobacterium tuberculosis lead to the formation of drug-resistant forms because of long-term use of anti-tuberculosis drugs. The Russian Federation is among the top three countries with a high burden of tuberculosis with multidrug resistance (MDR). The estimated number of cases of tuberculosis with MDR in the Russian Federation was 60,000, which corresponds to half the burden of the European Region in 2015. In the Irkutsk region from

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Kerimzhanova, B., A. Jumagaziyeva, N. Аkhatullina, Zh Iskakbayeva, and E. Sakhipov. "THE INHIBITING EFFECT OF FS-1 DRUG ON THE ANTIOXIDANT PROTECTION SYSTEM OF MYCOBACTERIA TUBERCULOSIS." SERIES CHEMISTRY AND TECHNOLOGY 6, no. 444 (2020): 134–42. http://dx.doi.org/10.32014/2020.2518-1491.108.

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Results of inhibitory action of FS-1 drug on antioxidant system of pathogenic mycobacteria tuberculosis, including resistant MDR strain, are presented. The study of the effect of FS-1 drug on the activity of the antioxidant system was carried out on the reference strain Mycobacterium tuberculosis H37Rv and MDR (rifampicin, isoniazid, streptomycin, ethambutol, еthionamide, kanamycin, cycloserine and pyrazinamide resistant) strain Mycobacterium tuberculosis 320. FS-1 drug under experimental conditions in vitro showed a new mechanism of action on mycobacteria tuberculosis - suppression of functio

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Khan, Taj Ali, Humaira Mazhar, Shamim Saleha, Hamid Nawaz Tipu, Niaz Muhammad, and Muhammad Nasser Abbas. "Interferon-Gamma Improves Macrophages Function against M. tuberculosis in Multidrug-Resistant Tuberculosis Patients." Chemotherapy Research and Practice 2016 (July 12, 2016): 1–6. http://dx.doi.org/10.1155/2016/7295390.

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Background. Mycobacterium tuberculosis (M. tuberculosis) that causes tuberculosis (TB) kills millions of infected people annually especially multidrug-resistant tuberculosis (MDR-TB). On infection, macrophages recognize the mycobacteria by toll-like receptor (TLR) followed by phagocytosis and control of mycobacteria. In addition, macrophages also secrete IL-12 to induce IFN-γ production by T, which, in turn, increases the phagocytosis and oxidative burst. Individuals with defects in innate or adaptive immunity exhibit increased susceptibility to M. tuberculosis. Understanding these immunologic

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Cabezas Vinueza, Leslie, and Patricia Jiménez Arias. "Distribution of Mycobacterium tuberculosis lineages in South America." Anatomía Digital 4, no. 3 (2021): 34–58. http://dx.doi.org/10.33262/anatomiadigital.v4i3.1755.

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Molecular genotyping of Mycobacterium tuberculosis allows for the identification of circulating lineages and sublineages in the population and their relationship with migratory movements. The purpose of this review is to describe the phylogeography of Mycobacterium tuberculosis reported in South American countries that was analyzed using genotyping tools, analyze the Tuberculosis hotspots for the region and determine the impact of the COVID-19 pandemic on the Tuberculosis control program. The Latin American Mediterranean (LAM) sublineage belonging to the Euro-American lineage (Lineage 4) prese

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Mourenza, Álvaro, José A. Gil, Luis M. Mateos, and Michal Letek. "Novel Treatments against Mycobacterium tuberculosis Based on Drug Repurposing." Antibiotics 9, no. 9 (2020): 550. http://dx.doi.org/10.3390/antibiotics9090550.

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Tuberculosis is the leading cause of death, worldwide, due to a bacterial pathogen. This respiratory disease is caused by the intracellular pathogen Mycobacterium tuberculosis and produces 1.5 million deaths every year. The incidence of tuberculosis has decreased during the last decade, but the emergence of MultiDrug-Resistant (MDR-TB) and Extensively Drug-Resistant (XDR-TB) strains of M. tuberculosis is generating a new health alarm. Therefore, the development of novel therapies based on repurposed drugs against MDR-TB and XDR-TB have recently gathered significant interest. Recent evidence, f

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Kumar, Parveen, Amit Singh, Umakant Sharma, Dharmendra Singh, M. P. Dobhal, and Sarman Singh. "Anti-mycobacterial activity of plumericin and isoplumericin against MDR Mycobacterium tuberculosis." Pulmonary Pharmacology & Therapeutics 26, no. 3 (2013): 332–35. http://dx.doi.org/10.1016/j.pupt.2013.01.003.

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Mohamed, Mohamed Abdelrahman, Omer Abdikarin Ali, Aamir Muse Osman, et al. "Assessment of drug-susceptible and multidrug-resistant tuberculosis (MDR-TB) in the Central Region of Somalia: A 3-year retrospective study." PLOS Global Public Health 3, no. 9 (2023): e0002319. http://dx.doi.org/10.1371/journal.pgph.0002319.

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Background Multidrug-resistant tuberculosis (MDR-TB) remains a public health emergency and a threat globally. Although increasing MDR-TB cases have been recently reported in Somalia, limited information is known. This study aims to determine the prevalence of drug-susceptible and MDR-TB in suspected patients referred to the TB Department in Mudug Hospital, Galkayo, Somalia, and identify potential factors associated with MDR-TB. Methods A 3-year hospital laboratory-based retrospective study was conducted by manually reviewing laboratory records of Mycobacterium tuberculosis specimens and GeneXp

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Sibuea, Christine Verawaty, Maria Oktaviana Pardosi, Ira Maylani Simbolon, and Paulus Adventus Tampubolon. "Polimorfisme Gen Vitamin D Receptor (VDR) BsmI pada Multi Drug Resistant Tuberculosis (MDR TB)"." Nommensen Journal of Medicine 9, no. 1 (2023): 49–52. http://dx.doi.org/10.36655/njm.v9i1.1199.

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 ABSTRACT Background : The increasing cases of Tuberculosis (TB) is a concerned health problem to the world, especially Indonesia, which Indonesia is the 2nd most TB cases in the world. The increase in TB cases is accompanied by the increase in Multi Drug Resistant Tuberculosis (MDR TB) cases. Genetic and immunity host factor, inadequate treatment and bacterial mutations affect the infection of MDR TB. Vitamin D has an important role in immune regulatory to eliminate Mycobacterium tuberculosis, as of it can affect the susceptibility to MDR TB. Purpose : The aim of this study

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Kadhim, Afraa Ali, Mohammed Faraj AL-Marjan, Kadhim Ali Kadhim, and Ahmed Asmar Manki. "Isolation of Mycobacterium tuberculosis and testing their susceptibility to antimicrobial agents by using Bactec 960." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 175–81. http://dx.doi.org/10.32947/ajps.v13i1.213.

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This study was done from 3/7/2011 to 1/1/2012 , different clinical samples were collected from (1235) patients that coming to the Specialized center for chest and respiratory diseases / Baghdad to investigate Mycobacterium tuberculosis and study their resistant to first and second line antimicrobial agents by using Bactec 960.The results obtained from direct smear examination with Ziehl – Neelsen stain in (294) patients that indicated these patients are Infected with tuberculosis . These samples has been cultured on solid medium Lowenstein Jensen media (L.J.) and liquid medium ( middle brook 7

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Nikmawati, A., Windarwati Windarwati, and Hardjoeno Hardjoeno. "RESISTENSI Mycobacterium Tuberculosis TERHADAP OBAT ANTI TUBERKULOSIS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 12, no. 2 (2018): 58. http://dx.doi.org/10.24293/ijcpml.v12i2.843.

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Patients infected with resistant Mycobacterium tuberculosis strain will be very difficult to cure by standard treatment. To evaluatethe drug resistance of Mycobacterium tuberculosis. A Cross sectional study was performed from January until July 2005. Samples wereobtained from sputum of the suspect tuberculosis. All samples were cultured in Lowenstein-Jensen Media and followed by sensitivity testaccording to resistance ratio method. Of 236 samples, there were 30% positive cultures. The percentage of mono-resistance to Isoniazidwas 70%, to Rifampicin 64.3%, to Ethambutol 62.8% and Streptomycin 6

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Teng, Tieshan, Jiafa Liu, and Hongping Wei. "Anti-Mycobacterial Peptides: From Human to Phage." Cellular Physiology and Biochemistry 35, no. 2 (2015): 452–66. http://dx.doi.org/10.1159/000369711.

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Mycobacterium tuberculosis is the major pathogen of tuberculosis (TB). With the growing problem of M. tuberculosis resistant to conventional antibiotics, especially multi-drug resistant tuberculosis (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB), the need for new TB drugs is now more prominent than ever. Among the promising candidates for anti-TB drugs, anti-mycobacterial peptides have a few advantages, such as low immunogenicity, selective affinity to prokaryotic negatively charged cell envelopes, and diverse modes of action. In this review, we summarize the recent progress in

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Cula, Eugenia. "Recent advances in the treatment of drug resistant tuberculosis." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 79, no. 2 (2024): 203–5. https://doi.org/10.52692/1857-0011.2024.2-79.38.

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Multidrug-resistant (MDR TB) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising advances in the paradigm of MDR TB treatment: new drugs have shown activity against Mycobacterium tuberculosis (MBT) and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the recommended regimens to treat MDR TB, and we also summarize new insights into the treatment of patients with MDR TB.

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Sridhar, Aarthi, Anjana Gopi, Abhilasha Dalal, and Divya Ravi. "Comparative study of different methods of microscopy followed by a culture method in the detection of mycobacterium tuberculosis in clinically and radiologically suspected cases of pulmonary tuberculosis." IP International Journal of Medical Microbiology and Tropical Diseases 7, no. 2 (2021): 108–15. http://dx.doi.org/10.18231/j.ijmmtd.2021.024.

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To compare the sensitivity of 2 microscopic methods for the diagnosis of Mycobacterium tuberculosis (M.tb) along with culture and drug susceptibility testing to first line drugs.: The cross-sectional study comprises 200 suspected cases of pulmonary tuberculosis both clinically and radiologically in KIMS, Bangalore over a period of 2 years. Samples (sputum/BAL fluid) were collected, processed and stained by Ziehl Neelson (ZN) and Fluorescent methods. Culture and drug susceptibilty testing was done for Streptomycin, Isoniazid, Rifampicin and Ethambutol by Mycobacterium growth indicator tube (MGI

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Abdelsadek, Hossam A., Hassan M. Sobhy, Kh F. Mohamed, Sahar H. A. Hekal, Amany N. Dapgh, and Ashraf S. Hakim. "Multidrug-resistant strains of Mycobacterium complex species in Egyptian farm animals, veterinarians, and farm and abattoir workers." October-2020 13, no. 10 (2020): 2150–55. http://dx.doi.org/10.14202/vetworld.2020.2150-2155.

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Background and Aim: Mycobacterium tuberculosis complex (MTBC) is a group of mycobacteria that are important human pathogens. Mycobacterium tuberculosis and Mycobacterium bovis cause serious chronic life-threatening disease and also significant economic losses in both production and remedication. Recently, emergence of multidrug-resistant tuberculosis (MDR-TB) complex has generated global recognition of the need for rapid and sensitive diagnosis and development of new treatments. The current study illustrates the isolation/identification of MTBC strains in specimens obtained from cows and human

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Peloquin, Charles A., and Shaun E. Berning. "Infection Caused by Mycobacterium Tuberculosis." Annals of Pharmacotherapy 28, no. 1 (1994): 72–84. http://dx.doi.org/10.1177/106002809402800115.

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OBJECTIVE: To update readers on the clinical management of infections caused by Mycobacterium tuberculosis, to provide a general description of the organism, culture and susceptibility testing, and clinical manifestations of the disease, and to provide several aspects of the treatment of the disease, including historical perspective, current approaches, and research opportunities for the future. DATA SOURCES: The current medical literature, including abstracts presented at recent international meetings, is reviewed. References were identified through MEDLINE, MEDLARS II, Current Contents, and

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Rao, Komal Umashankar, Ping Li, Charlotte Welinder, et al. "Mechanisms of a Mycobacterium tuberculosis Active Peptide." Pharmaceutics 15, no. 2 (2023): 540. http://dx.doi.org/10.3390/pharmaceutics15020540.

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Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. Previously, we identified a cationic host defense peptide with activity against Mycobacterium tuberculosis in vivo and with a bactericidal effect against MDR M. tuberculosis at therapeutic concentrations. To understand the mechanisms of this peptide, we investigated its interactions with live M. tuberculosis and liposomes as a model. Peptide interactions with M. tuberculosis inner membranes induced tube-shaped membranous structures and massive vesicle formation, thus leading to bubbling cell death and ghost cel

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MOHD, JASEEM Khan. "INCONGRUENT RESISTANCE TO AMINOGLYCOSIDES IN MULTIDRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS." INTERNATIONAL JOURNAL OF SCIENCES AND APPLIED RESEARCH 12, no. 2 (2025): 01–06. https://doi.org/10.5281/zenodo.14868929.

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Since the discovery of the bactericidal activity of aminoglycosides, streptomycin, kanamycin, amikacin, and capreomycin (a macrocyclic peptide) have been widely used to treat tuberculosis and multidrug-resistant (MDR) tuberculosis. In general practice, resistance to kanamycin is often used as the sole criterion for defining extensively drug-resistant tuberculosis, assuming that all other drugs in this group or related drugs are resistant to certain strains. However, the assumption of cross-resistance between drugs in the same group is not always true for Mycobacterium tuberculosis. This prompt

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Chand, Arun Bahadur, Ajaya Basnet, Bhagwan Maharjan, et al. "Drug-resistant Mycobacterium tuberculosis among Nepalese patients at a tuberculosis referral center." PLOS ONE 19, no. 5 (2024): e0301210. http://dx.doi.org/10.1371/journal.pone.0301210.

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Background Multidrug-resistant tuberculosis (MDR-TB), characterized by isoniazid and rifampicin resistance, is caused by chromosomal mutations that restrict treatment options and complicate tuberculosis management. This study sought to investigate the prevalence of pre-extensively drug-resistant (pre-XDR) and extensively drug-resistant (XDR) tuberculosis, as well as mutation pattern, in Nepalese patients with MDR/rifampicin-resistant (RR)-TB strains. Methods A cross-sectional study was conducted on MDR/RR-TB patients at the German Nepal Tuberculosis Project from June 2017 to June 2018. The MTB

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Mashidayanti, Aulia, Nurlely Nurlely, and Nani Kartinah. "Faktor Risiko Yang Berpengaruh Pada Kejadian Tuberkulosis dengan Multidrug-Resistant Tuberculosis (MDR-TB) di RSUD Ulin Banjarmasin." Jurnal Pharmascience 7, no. 2 (2020): 139. http://dx.doi.org/10.20527/jps.v7i2.7928.

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MDR-TB (Multidrug-Resistant Tuberculosis) adalah salah satu jenis TB yang resisten dengan OAT (Obat Anti Tuberculosis) dengan resisten terhadap 2 obat anti tuberculosis yang paling ampuh yaitu rifampisin dan isoniazid. Obat rifampisin dan isoniazid sudah tidak efektif dalam membunuh kuman mycobacterium tuberkulosis dikarenakan kuman yang sudah resisten terhadap obat tersebut. MDR-TB merupakan suatu permasalahan yang menjadi hambatan utama dunia dalam pemberantasan TB. Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor risiko apa saja yang dapat berpengaruh pada kejadian tuberkulos

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Vinod, Sushmita, Prasanth G., and Gangadharan V. "A rare case of primary disseminated multi-drug resistant tuberculosis." International Journal of Advances in Medicine 9, no. 9 (2022): 973. http://dx.doi.org/10.18203/2349-3933.ijam20222111.

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Tuberculosis (TB) is the commonest cause of infection-related death globally. Disseminated tuberculosis (TB) is a life-threatening disease which results from the hematogenous spread of Mycobacterium tuberculosis. Genitourinary tuberculosis (GUTB) is usually caused as a result of the hematogenous spread of the mycobacteria during the initial infection. The patient's clinical presentation may vary from asymptomatic to non-specific symptoms related to the organ involved and may also overlap with urinary tract infections caused by other pathogens hence delaying the diagnosis. Here we report one su

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Sulistyowati, Titiek, Soedarsono, and Ni Made Mertaniasih. "Mutant vary region of pncA gene sequence of pyrazinamide resistance among multidrug resistant Mycobacterium tuberculosis isolates." Journal of Clinical Microbiology and Infectious Diseases 2, no. 1 (2022): 6–10. http://dx.doi.org/10.51559/jcmid.v2i1.18.

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ABSTRACT Introduction: Pyrazinamide (PZA) is one of the potent front-line drugs that act as antituberculosis (antiTB) for nonresistant or resistant Mycobacterium tuberculosis. Mutation of pncA gene is considered to be main target of PZA resistance mechanism. This study aims to determine the mutant gene sequences, location, and correlation of pncA gene mutations with PZA resistance in MDR Mycobacterium tuberculosis as a base for the rapid molecular examination. Objective: This study aims to determine the mutant gene sequence and location of pncA gene with PZA resistance in multidrug resistant (

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Huang, Hairong, Nan Ding, Tingting Yang, et al. "Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China." Clinical Infectious Diseases 69, no. 3 (2018): 405–13. http://dx.doi.org/10.1093/cid/ciy883.

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AbstractBackgroundThe increase in multidrug-resistant tuberculosis (MDR-TB) severely hampers tuberculosis prevention and control in China, a country with the second highest MDR-TB burden globally. The first nationwide drug-resistant tuberculosis surveillance program provides an opportunity to comprehensively investigate the epidemiological/drug-resistance characteristics, potential drug-resistance mutations, and effective population changes of Chinese MDR-TB.MethodsWe sequenced 357 MDR strains from 4600 representative tuberculosis-positive sputum samples collected during the survey (70 countie

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Waqar Mazhar, Muhammad. "Mycobacterium Tuberculosis, Culturing and PCR Optimization." Annals of Experimental and Molecular Biology 3, no. 1 (2021): 1–5. http://dx.doi.org/10.23880/aemb-16000108.

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The genus Acinetobacter baumannii has undergone substantial taxonomic modifications over the last 30 years. Acinetobacter baumannii is one of the most important representatives of the genus and pathogen for healthcare facilities globally. Over the last 15 years, its clinical significance shows that it has the ability to acquire resistance against antibiotics in this threatening antibiotic era. Naturally A.baumannii can easily be isolated from different sources throughout whole world, found mostly in water, soil, sputum and many healthcare environments, is a non-fermenting, non-spore forming an

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Zabost, Anna, Dorota Filipczak, Włodzimierz Kupis, et al. "Use of a FluoroType® System for the Rapid Detection of Patients with Multidrug-Resistant Tuberculosis—State of the Art Case Presentations." Diagnostics 12, no. 3 (2022): 711. http://dx.doi.org/10.3390/diagnostics12030711.

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According to the World Health Organization (WHO), there were 465,000 cases of tuberculosis caused by strains resistant to at least two first-line anti-tuberculosis drugs: rifampicin and isoniazid (MDR-TB). In light of the growing problem of drug resistance in Mycobacterium tuberculosis across laboratories worldwide, the rapid identification of drug-resistant strains of the Mycobacterium tuberculosis complex poses the greatest challenge. Progress in molecular biology and the development of nucleic acid amplification assays have paved the way for improvements to methods for the direct detection

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Hameed, Saif, Rahul Pal, and Zeeshan Fatima. "Iron Acquisition Mechanisms: Promising Target Against Mycobacterium tuberculosis." Open Microbiology Journal 9, no. 1 (2015): 91–97. http://dx.doi.org/10.2174/1874285801509010091.

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Continuous deployment of antitubercular drugs in treating Tuberculosis (TB) caused byMycobacterium tuberculosis(MTB) has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed asMulti-DrugResistance (MDR-TB). Despite reasonable documentation of major factors which contribute to MDR mechanisms, it appears unavoidable to consider novel mechanisms combating MDR. The ability of pathogenic MTB, to sense and become accustomed to changes in the host environment is essential for its survival and confers the basis of their success as dreadful

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Palacios, Jacqueline Barrios, Jorge Barrios-Payán, Dulce Mata-Espinosa, et al. "In Vitro, In Vivo and In Silico Assessment of the Antimicrobial and Immunomodulatory Effects of a Water Buffalo Cathelicidin (WBCATH) in Experimental Pulmonary Tuberculosis." Antibiotics 12, no. 1 (2022): 75. http://dx.doi.org/10.3390/antibiotics12010075.

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Tuberculosis (TB) is considered the oldest pandemic in human history. The emergence of multidrug-resistant (MDR) strains is currently considered a serious global health problem. As components of the innate immune response, antimicrobial peptides (AMPs) such as cathelicidins have been proposed to have efficacious antimicrobial activity against Mycobacterium tuberculosis (Mtb). In this work, we assessed a cathelicidin from water buffalo, Bubalus bubalis, (WBCATH), determining in vitro its antitubercular activity (MIC), cytotoxicity and the peptide effect on bacillary loads and cytokines producti

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Olutayo, Israel Falodun, Simeon Cadmus Idowu, and Ezekiel Fagade Obasola. "Patterns of drug resistance in Mycobacterium tuberculosis from tuberculosis patients in Ibadan Nigeria." MicroMedicine 9, no. 1 (2021): 8–17. https://doi.org/10.5281/zenodo.4288506.

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The success of the global tuberculosis (TB) control program has been threatened with drug resistant strains emergence; especially the Multidrug Resistant Tuberculosis (MDR-TB). Despite that Nigeria is one of the countries with high tuberculosis burden, little is known on the magnitude of MDR-TB in the country. This study was to determine drug resistant patterns of <em>Mycobacterium tuberculosis</em> isolated from patients that attended Directly Observed Treatment Short-course (DOTS) centres in Ibadan, Nigeria. Sputum samples collected from confirmed TB patients were processed using the N-acety

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Hassan, Jabbar S., Bushra J. Al-Tamimi, Thanaa R. Abdulrahman, and Qudas W. Jamal. "RESISTANCE MECHANISMS TO FIRST LINE DRUG IN MYCOBACTERIUM TUBERCULOSIS: A REVIEW." Iraqi Journal of Medical Sciences 20, no. 1 (2022): 35–43. http://dx.doi.org/10.22578/ijms.20.1.5.

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The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains, identified as resistant to at least isoniazid and rifampin, these two drugs form the backbone of the first line drug which is used for tuberculosis (TB) treatment, unresponsive has hampered TB control. As a result of the nearly universal calculation of with half a million new cases of MDR/first line drug TB per year, it is important to keep the database up to date awareness of the processes that contribute to the emergence of MDR Mtb. This resistance is produced for a variety of reasons, including genetic, mic

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