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Journal articles on the topic 'Meclizine'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Gowramma, Byran, Ramachandran Senthil Kumar, Rajagopal Kalirajan, Kaviarasan Lakshmanan, and Subramanian Nainar Meyyanathan. "Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC Method." Current Drug Research Reviews 12, no. 1 (2020): 63–71. http://dx.doi.org/10.2174/2589977511666191211123337.

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Objective: A basic, powerful and isocratic chiral fluid chromatographic technique was created and approved for the enantiomeric partition of meclizine hydrochloride in pharmaceutical dose structure. Methods: The chromatographic partition was accomplished on Phenomenex® Lux Cellulose 1 (250 mm x 4.6 mm i.d, 5 μm molecule size) section utilizing portable stage framework containing acetonitrile: 25mM ammonium bicarbonate (75:25%v /v). The versatile stage was siphoned on the segment at the stream pace of 1.0 mL/min, and UV recognition was done at 230 nm. Result: The breaking points of recognition

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2

Samantha, McGlone. "Meclizine prescriptions in the Emergency Department and return visits in the elderly population." Annals of Clinical Hypertension 5, no. 1 (2021): 003–7. http://dx.doi.org/10.29328/journal.ach.1001026.

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Background: Meclizine is a commonly prescribed medication for patients discharged from the Emergency Department (ED) with a diagnosis of peripheral vertigo, however it is on the Beers list of medications to avoid in elderly patients. Objectives: This study aims to determine the correlation between use of meclizine and return visits to the ED within 1 week in patients > 65 years old. Methods: This is a retrospective observational study conducted at 2 urban tertiary care EDs over 5 years. Inclusion criteria included patients > 65 years who were given meclizine in the ED or discharged with

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3

Sharma, Sanjay Kumar, and Rakesh P. Patel. "Enhancing the Solubility and Dissolution Rate of Meclizine Hydrochloride by Inclusion Complex." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 57–64. http://dx.doi.org/10.22270/jddt.v9i4.2981.

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Meclizine Hydrochloride is an Anti-Histamine drugs with very low bioavailability that can be improved by increasing its solubility and dissolution rate. The aim of this study is to enhance dissolution of Meclizine Hydrochloride as a model hydrophobic drug through application of inclusion complex technology. It was formulated as inclusion complex compact, and its dissolution property is evaluated and compared with marketed product of Meclizine Hcl tablet. The newly formulated drug and the interaction between excipients was examined by, Fourier-transform infrared spectroscopy, and differential s

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4

Matsushita, Masaki, Hiroshi Kitoh, Kenichi Mishima, et al. "Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia." PLOS ONE 18, no. 7 (2023): e0283425. http://dx.doi.org/10.1371/journal.pone.0283425.

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Achondroplasia (ACH) is a common skeletal dysplasia characterized by a disproportionately short stature. We found that meclizine, which is an over-the-counter drug for motion sickness, inhibited the fibroblast growth factor receptor 3 (FGFR3) gene using a drug repositioning strategy, and meclizine 1 and 2 mg/kg/day promoted bone growth in a mouse model of ACH. A previous phase 1a clinical trial for children with ACH demonstrated that a single dose of meclizine 25 and 50 mg was safe and that the simulated plasma concentration achieved steady state approximately 10 days after the first dose. The

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5

Singh, Harmandeep, Rupinder Kaur Sodhi, Simerjeet Kaur Chahal, and Jitender Madan. "Meclizine ameliorates memory deficits in streptozotocin-induced experimental dementia in mice: role of nuclear pregnane X receptors." Canadian Journal of Physiology and Pharmacology 98, no. 6 (2020): 383–90. http://dx.doi.org/10.1139/cjpp-2019-0421.

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Pregnane X receptors (PXRs) regulate the expression of ATP-binding cassette proteins transporters and organic anion transporting polypeptides responsible for influx/efflux of xenobiotics across the brain. Ligand activation of PXR augments the expression of P-gp and promotes amyloid-β clearance across the blood–brain barrier. Dementia was induced in mice by intacerebroventricular administration of streptozotocin (STZ) followed by treatment with meclizine, a PXR agonist, and subsequently exposed to the Morris water maze test and biochemical and histopathological analysis to evaluate the effect o

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6

Wiener, Guy, Anna Jamison, and Dror Tal. "Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model." Diving and Hyperbaric Medicine Journal 54, no. 4 (2024): 296–300. https://doi.org/10.28920/dhm54.4.296-300.

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Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness. The over-the-counter medication meclizine is an anticholinergic and antihistaminergic agent that has gained popularity in the treatment of seasickness. Reports have shown the inhibitory effect that acetylcholine has on glutamate, a main component in the mechanism

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7

Bhide, Prashant, and Reeshwa Nachinolkar. "FORMULATION DEVELOPMENT AND CHARACTERISATION OF MECLIZINE HYDROCHLORIDE FAST DISSOLVING TABLETS USING SOLID DISPERSION TECHNIQUE." International Journal of Applied Pharmaceutics 10, no. 4 (2018): 141. http://dx.doi.org/10.22159/ijap.2018v10i4.26493.

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Objective: The aim of the present investigation was to design and evaluate fast dissolving tablet (FDT) for the oral delivery containing solid dispersion of meclizine (MCZ) hydrochloride, an antiemetic drug.Methods: The solubility of meclizine was increased by preparing solid dispersions using mannitol as a carrier by fusion method. The prepared solid dispersion, was subjected for in vitro drug release, percent practical yield, drug content, infrared spectroscopy (IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Optimized solid dispersion was incorporated to pr

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8

Sri, A. Navya, K. Shiva Prasad, Hafsa Tahreem, et al. "A novel analytical method development and validation of estimation of meclizine HCL by UV spectroscopic method." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 3 (2023): 953–56. http://dx.doi.org/10.54660/.ijmrge.2023.4.3.953-956.

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A new simple, accurate, rapid, precise, reproducible and cost-effective spectrophotometric method for the quantitative estimation of Meclizine Hcl. The developed UV spectrophotometric method for the quantitative estimation of meclizine HCl is based on measurement of absorption at maxima wavelength 232nm using Methanol: DMF (40:60). The standard and sample solution were prepared by using Methanol: DMF as a solvent. Quantitative determination of the drug was performed at wavelength range 228-234nm.The linearity was established over the concentration range 5, 10, 15, 20, 25, µg/ml for the meclizi

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9

Kumar, Anubhav, Ashish Jain, Pradeep Kumar Yadav, and Akhlesh Kumar Singhai. "Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents." Journal of Drug Delivery and Therapeutics 12, no. 4 (2022): 7–14. http://dx.doi.org/10.22270/jddt.v12i4.5413.

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The proposed study is development of oro-dispersible tablet containing meclizine hydrochloride solid dispersion (FMODDs) formulation with using natural superdisintegrant with direct compression. The superdisintegrants and its concentration shall be during the preparation of FMODDs with meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), Ac-Di-Sol, crosspovidone (CP), Spray dried lactose and microcrystalline cellulose (MCC)} which were used alone and in various combination and man

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10

Al-Madhagi, Wafa M., Arwa Alshargabi, Abdulkarim K. Y. Alzomor, and Olla Sharhan. "Formulation of New Chewable Oral Dosage Forms of Meclizine and Pyridoxine Hydrochloride." Advances in Pharmacological and Pharmaceutical Sciences 2023 (July 29, 2023): 1–6. http://dx.doi.org/10.1155/2023/5512379.

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Nausea and vomiting are symptoms associated with a lot of diseases and oral tablets may be unprofitable for patients especially those suffering from nausea and vomiting. Therefore, this study aimed to formulate a new meclizine and pyridoxine combination formula for chewable tablets and provide rapid drug absorption and decrease motion sickness. The new chewable formulation has been prepared to provide fast action, is more acceptable, and could be used for all age categories. Seven trials haves been carried out to prepare to find the suitable one where formula 7 of the chewable gum preparation

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11

Sandoval, Jose A., Alexey Tomilov, Sandipan Datta, et al. "Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells." Pharmaceuticals 13, no. 12 (2020): 419. http://dx.doi.org/10.3390/ph13120419.

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Glioblastoma (GBM) is an aggressive tumor of the brain, with an average post-diagnosis survival of 15 months. GBM stem cells (GBMSC) resist the standard-of-care therapy, temozolomide, and are considered a major contributor to tumor resistance. Mammalian target of rapamycin Complex 1 (mTORC1) regulates cell proliferation and has been shown by others to have reduced activity in GBMSC. We recently identified a novel chemical series of human-safe piperazine-based brain-penetrant mTORC1-specific inhibitors. We assayed the piperazine-mTOR binding strength by two biophysical measurements, biolayer in

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12

Lal Verma, Abhay Murari, and Poonam Negi. "Formulation and evaluation of oral medicated jelly of meclizine HCl." Pharmaspire 15, no. 04 (2023): 225–29. http://dx.doi.org/10.56933/pharmaspire.2023.15134.

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The present study is conducted with the aim of formulating and evaluating an oral medicated jelly of meclizine hydrochloride for the treatment of motion sickness, nausea, and vomiting. Jellies are thick viscous fluid to semisolid in nature. The jellies form can be swallowed easily without water and they are soft and smooth. Medicated jellies of meclizine hydrochloride were formulated using polymers such as gelatin, pectin, and sodium alginate. The prepared medicated jellies were evaluated for their physico-chemical properties such as appearance, stickiness, pH, viscosity, drug release, and dru

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13

Gao, Liansheng, Chun Wang, Bing Qin, et al. "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats." Cell Transplantation 29 (January 1, 2020): 096368972095022. http://dx.doi.org/10.1177/0963689720950226.

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Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is a critical regulator for energy metabolism and proven to have antiapoptotic effects. This study aimed to investigate the neuroprotective role of PFKFB3 in t-SCI. A compressive clip was introduced to establish the t-SCI model. Herein, we identified that PFKFB3 was extensively distributed in neurons, and PFKFB3 levels significantly increased and peaked 24 h after t-SCI. Additionally, knockdown of PFKFB3 inhibit

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14

Khorshed, Ahmed A., Mohamed Khairy, Sherif A. Elsafty, and Craig E. Banks. "Disposable screen-printed electrodes modified with uniform iron oxide nanocubes for the simple electrochemical determination of meclizine, an antihistamine drug." Analytical Methods 11, no. 3 (2019): 282–87. http://dx.doi.org/10.1039/c8ay02405g.

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15

Sansone, Randy A., and Christopher D. Sears. "The Successful Use of Meclizine in Panic Disorder." Journal of Clinical Psychiatry 65, no. 9 (2004): 1285–86. http://dx.doi.org/10.4088/jcp.v65n0918e.

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16

Gohil, V. M., N. Offner, J. A. Walker, et al. "Meclizine is neuroprotective in models of Huntington's disease." Human Molecular Genetics 20, no. 2 (2010): 294–300. http://dx.doi.org/10.1093/hmg/ddq464.

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17

Wibble, Tobias, Johanna Engström, Luca Verrecchia, and Tony Pansell. "The effects of meclizine on motion sickness revisited." British Journal of Clinical Pharmacology 86, no. 8 (2020): 1510–18. http://dx.doi.org/10.1111/bcp.14257.

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18

Wang, Zhijun, Benjamin Lee, Daniel Pearce, et al. "Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption." Journal of Clinical Pharmacology 52, no. 9 (2012): 1343–49. http://dx.doi.org/10.1177/0091270011414575.

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19

Vemula, Sateesh Kumar, and Mohan Vangala. "Formulation Development and Characterization of Meclizine Hydrochloride Sublimated Fast Dissolving Tablets." International Scholarly Research Notices 2014 (August 25, 2014): 1–8. http://dx.doi.org/10.1155/2014/281376.

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The intention of present research is to formulate and develop the meclizine hydrochloride fast dissolving tablets using sublimation method to enhance the dissolution rate. In this study an attempt was made to fasten the drug release from the oral tablets by incorporating the superdisintegrants and camphor as sublimating agent. The prepared fast dissolving tablets were subjected to precompression properties and characterized for hardness, weight variation, friability, wetting time, water absorption ratio, and disintegration time. From in vitro release studies, the formulation F9 exhibited fast

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20

Sugunamma, Kallu, and Dr U. Mohan Kumar. "Formulation, development and evaluation of meclizine HCL transdermal patches." Future Journal of Pharmaceuticals and Health Sciences 5, no. 3 (2025): 1–12. https://doi.org/10.26452/fjphs.v5i3.770.

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This work used a solvent evaporation approach with polyethylene glycol (PEG 400) as a plasticizer to develop a transdermal patch with meclizine Hcl using varying ratios of hydrophilic and hydrophobic polymeric systems. FT-IR spectroscopy research was used to examine the drug's and the polymers' physicochemical compatibility. The physicochemical characteristics, skin irritation, in vitro drug release, ex-vivo permeation investigations across rat abdomen skin, and stability studies of the developed patches were assessed. The medication and the polymers utilised did not interact, according to the

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21

Tahir, Muhammed, Ghulam Fareed, Abdul Hakim, Asad Ali, Haitham Akaash, and Arslan Akhtar. "Role of Vestibular Suppressants (B. Histine, Cinnarizine, Meclizine) after Successful Epley’s Maneuvers in Benign Paroxysmal Positional Vertigo." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 264–67. http://dx.doi.org/10.53350/pjmhs2023173264.

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Background: Benign positional paroxysmal vertigo (BPPV) is one of the most prevalent causes of dizziness, affecting between 11 and 64 people per 100,000 each year and 2.4% of the population overall. Vestibular suppressants have been shown in recent studies to be effective in reducing residual symptoms after a successful Epley’s maneuvers, however to the best of our knowledge, very few research have analyzed the features of residual symptoms in BPPV patients following Epley’s maneuvers. There has been no definitive research on what causes symptoms duration, canal involvement, cumulative success

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22

Mahrous, Gamal, Gamal Shazly, and Mohamed Ibrahim. "FORMULATION AND EVALUATION OF MECLIZINE HCl ORALLY DISINTEGRATING TABLETS." Bulletin of Pharmaceutical Sciences. Assiut 34, no. 2 (2011): 141–48. http://dx.doi.org/10.21608/bfsa.2011.63260.

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23

Foda, N. H., H. W. Jun, and J. W. McCall. "Quantitative Analysis of Meclizine in Tablet Formulations by HPLC." Analytical Letters 21, no. 7 (1988): 1177–88. http://dx.doi.org/10.1080/00032718808055505.

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24

Kishi, Seiji, Gabriela Campanholle, Vishal M. Gohil, et al. "Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury." EBioMedicine 2, no. 9 (2015): 1090–101. http://dx.doi.org/10.1016/j.ebiom.2015.07.035.

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25

Baloh, Robert W. "Disequilibrium and gait disorders in older people." Reviews in Clinical Gerontology 12, no. 1 (2002): 21–30. http://dx.doi.org/10.1017/s0959259802012145.

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Disequilibrium is typically described as a feeling of dizziness when standing or walking that is not present while sitting or lying down. Since dizziness is such a common symptom in older people, the symptom may be dismissed as a normal aging phenomenon. On the other hand, the patient may be inappropriately given nonspecific treatment for dizziness such as meclizine or diazepam, which may worsen the condition, due to sedation.

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26

Patel, Priti N., and Emily M. Ambizas. "Meclizine: Safety and Efficacy in the Treatment and Prevention of Motion Sickness." Clinical Medicine Insights: Therapeutics 3 (January 2011): CMT.S6237. http://dx.doi.org/10.4137/cmt.s6237.

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Motion sickness is a self-limiting but uncomfortable phenomenon experienced by many people. It is common during civilian travel and also among professionals during travel or military manoeuvres. Meclizine is a piperzine antihistamine that is effective for the prevention and treatment of motion sickness, particularly during mild civilian travel. It is well tolerated with few adverse effects and its oral dosage form is convenient for patients to take prior to exposure to motion as a preventative measure.

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27

Mastiholimath, Vinayak Shivamurthi, Sujit Prabhu Khope, Pallavi Raosaheb Chiprikar, Anand Shripal Ammanage, and Umeshkumar Dinesh Patel. "Nano-suspension loaded mucoadhesive mouth dissolving film of meclizine hydrochloride." Journal of Medical pharmaceutical and allied sciences 12, no. 3 (2023): 5874–84. http://dx.doi.org/10.55522/jmpas.v12i3.5037.

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Meclizine Hydrochloride belongs to class H1 antagonist, antiemetic and anti-vertigo in nature, it is a Biopharmaceutical classification system (BCS) class II drug and is practically insoluble in water. The bottom-up approach was used in the formulation of nanosuspension in which methanol and millipore water was used as solvent and anti-solvent respectively, the stabilizers used for preparation were Polyvinylpyrrolidone K30 (PVP K30) and Hydroxypropyl Methylcellulose E15 (HPMC E15) which were found to be compatible with the formulation after Fourier Transform Infrared (FTIR) and Differential sc

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28

Patel, Priti N., and Danielle C. Ezzo. "Withdrawal symptoms after discontinuation of transdermal scopolamine therapy: Treatment with meclizine." American Journal of Health-System Pharmacy 66, no. 22 (2009): 2024–26. http://dx.doi.org/10.2146/ajhp080569.

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29

Kuykendall, Jim R., and Richard S. Rhodes. "Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime." Annals of Pharmacotherapy 38, no. 11 (2004): 1968–69. http://dx.doi.org/10.1345/aph.1e231.

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30

Onur, Feyyaz, and Erdal Dinc. "Simultaneous Determination of Caffeine and Meclizine Dihydrochloride in Sugar-Coated Tablets." Analytical Letters 28, no. 14 (1995): 2521–34. http://dx.doi.org/10.1080/00032719508004032.

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31

Molloy, D. W. "Memory Loss, Confusion, and Disorientation in an Elderly Woman Taking Meclizine." Journal of the American Geriatrics Society 35, no. 5 (1987): 454–56. http://dx.doi.org/10.1111/j.1532-5415.1987.tb04668.x.

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32

Ho, Yu Hsiang, Hsin Lung Wu, Shou Mei Wu, Su Hwei Chen, and Hwang Shang Kou. "Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis." Analytical and Bioanalytical Chemistry 376, no. 6 (2003): 859–63. http://dx.doi.org/10.1007/s00216-003-2015-x.

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33

KIMURA, Susumu, Teruko IMAI, Yorishige IMAMURA, Masao UENO, Takeo IIJIMA, and Masaki OTAGIRI. "Dissolution and Absorption Behavior of Meclizine Dihydrochloride from Soft Gelatin Capsules." YAKUGAKU ZASSHI 109, no. 10 (1989): 755–59. http://dx.doi.org/10.1248/yakushi1947.109.10_755.

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34

Gohil, Vishal M., Lin Zhu, Charli D. Baker, et al. "Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism." Journal of Biological Chemistry 288, no. 49 (2013): 35387–95. http://dx.doi.org/10.1074/jbc.m113.489237.

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35

Schmitt, L. G., and J. E. Shaw. "Alleviation of Induced Vertigo: Therapy With Transdermal Scopolamine and Oral Meclizine." Archives of Otolaryngology - Head and Neck Surgery 112, no. 1 (1986): 88–91. http://dx.doi.org/10.1001/archotol.1986.03780010090017.

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36

Setiyono, Mashuri, and Nahdiya Sabrina. "Formulation of Criminal Law Policy against Drug Users without a Distribution License." EAS Journal of Humanities and Cultural Studies 4, no. 6 (2022): 234–38. http://dx.doi.org/10.36349/easjhcs.2022.v04i06.003.

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Regarding drugs that do not have a distribution permit, it is necessary to understand the drugs in question beforehand. Medicine itself means that it is made from ingredients obtained directly from natural Indonesian ingredients, processed based on experience and used in medicine. In principle, drugs can benefit human health, but if the drugs do not have a distribution permit, of course, the drug will cause human disease. Drugs that do not have a distribution permit under the Health Act are widely circulated in the community, including hard drugs. Several drugs are prohibited from circulation,

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37

Saad, Ahmed S., Mohammed E. Draz, Ibrahim A. Naguib, Hala E. Zaazaa, Adel S. Lashien, and Fatma F. Abdallah. "Adoption of Advanced Chemometric Methods for Determination of Pyridoxine HCl, Cyclizine HCl, and Meclizine HCl in the Presence of Related Impurities: A Comparative Study." Journal of AOAC INTERNATIONAL 105, no. 2 (2021): 630–40. http://dx.doi.org/10.1093/jaoacint/qsab141.

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Abstract Background Noising is an undesirable phenomenon accompanying the development of widely used chemometric models such as partial least square regression (PLSR) and support vector regression (SVR). Objective Optimizations of these chemometric models by applying orthogonal projection to latent structures (OPLS) as a preprocessing step which is characterized by canceling noise is the purpose of this research study. Additionally, a comprehensive comparative study between the developed methods was undertaken highlighting pros and cons. Methods OPLS was conducted with PLSR and SVR for quantit

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38

RAYMOND, ELIZABETH G., MITCHELL D. CREININ, KURT T. BARNHART, AMY E. LOVVORN, R. WESLEY ROUNTREE, and JAMES TRUSSELL. "Meclizine for Prevention of Nausea Associated With Use of Emergency Contraceptive Pills." Obstetrics & Gynecology 95, no. 2 (2000): 271–77. http://dx.doi.org/10.1097/00006250-200002000-00020.

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39

Rongen, Gerard A. "High Dose Meclizine Prevents Renal Ischemia–Reperfusion Injury in Healthy Male Mice." EBioMedicine 2, no. 9 (2015): 1012–13. http://dx.doi.org/10.1016/j.ebiom.2015.09.016.

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40

Feitosa, R. F. G., G. B. Melcíades, A. M. S. Assreuy, M. F. G. Rocha, R. A. Ribeiro, and A. A. M. Lima. "The pharmacological profile of ovalbumin-induced paw oedema in rats." Mediators of Inflammation 11, no. 3 (2002): 155–63. http://dx.doi.org/10.1080/09622935020138000.

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Rats are commonly used in anaphylaxis models, mainly in intestinal anaphylaxis. Hypersensitivity mechanisms are complex and they are not clearly defined. Ovalbumin (OVA) is commonly used for studies on the hypersensitivity mechanism. However, the potential pro-inflammatory mediators induced by this antigen in the model of paw oedema in immunized rats are still not completely understood. This work examines the pharmacological modulation of several mediators involved in rat hind paw immune oedema induced by OVA. Wistar rats were previously immunized (14-18 days) with OVA (30 μg, intraperitoneall

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41

Levinson, Harold N. "Dramatic Favorable Responses of Children with Learning Disabilities or Dyslexia and Attention Deficit Disorder to Antimotion Sickness Medications: Four Case Reports." Perceptual and Motor Skills 73, no. 3 (1991): 723–38. http://dx.doi.org/10.2466/pms.1991.73.3.723.

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Responses of four learning disabled children who showed dramatic improvements to one or more antimotion-sickness-antihistamines and -stimulants are described qualitatively. These cases were selected from a prior quantitative study in which three antihistamines (meclizine, cyclizine, dimenhydrinate) and three stimulants (pemoline, methylphenidate, dextroamphetamine) were tested in variable combinations (using a specific clinical method) for favorable responses by 100 children characterized by diagnostic evidence of learning disabilities and cerebellar-vestibular dysfunctioning. Pending validati

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42

NANE, İkbal Demet, and Ebru ÇUBUK DEMİRALAY. "Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures." Journal of Research in Pharmacy 25, no. 1 (2021): 1. http://dx.doi.org/10.35333/jrp.2021.290.

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43

Sun, Juanjuan, Jing Liu, Juanjuan Zhang, and Honghui Xia. "Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability improvement." Journal of Drug Delivery Science and Technology 63 (June 2021): 102432. http://dx.doi.org/10.1016/j.jddst.2021.102432.

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44

NANE, İkbal Demet, and Ebru ÇUBUK DEMİRALAY. "Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures." Journal of Research in Pharmacy 25, no. 1 (2021): 1. http://dx.doi.org/10.35333/jrp.2021.290.

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45

Ghareeb, M. "Preparation and characterization of orodispersible tablets of Meclizine Hydrochloride by wet granulation method." African Journal of Pharmacy and Pharmacology 7, no. 28 (2013): 1969–73. http://dx.doi.org/10.5897/ajpp12.1269.

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Al-Jallad, T., Z. Al-Kurdi, A. Badwan, and A. M. Y. Jaber. "Simultaneous Determination of Pyridoxine Hydrochloride and Meclizine Hydrochloride in Tablet Formulations by HPLC." Pharmacy and Pharmacology Communications 5, no. 8 (1999): 479–83. http://dx.doi.org/10.1211/146080899128735199.

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Wang, Zhijun, Shuai Qian, Qizhi Zhang, and Moses S. S. Chow. "Quantification of meclizine in human plasma by high performance liquid chromatography–mass spectrometry." Journal of Chromatography B 879, no. 1 (2011): 95–99. http://dx.doi.org/10.1016/j.jchromb.2010.11.022.

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von Brevern, Michael, and Thomas Lempert. "Vestibular Migraine: Treatment and Prognosis." Seminars in Neurology 40, no. 01 (2019): 083–86. http://dx.doi.org/10.1055/s-0039-3402067.

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AbstractTreatment of vestibular migraine currently lacks a firm scientific basis, as high quality randomized controlled trials are not available. Therefore, recommendations are largely borrowed from the migraine sphere. The first therapeutic step is explanation and reassurance. Many patients do not need pharmacological treatment, as attacks may be infrequent and tolerable. Acute attacks can be ameliorated in some patients with antiemetic drugs such as diphenhydramine, meclizine, and metoclopramide. Frequent attacks may warrant pharmacological prophylaxis with metoprolol, amitriptyline, topiram

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Roy, Deblina, and Gautam Panda. "Base-Mediated 1,6-Aza-Michael Addition of Heterocyclic Amines and Amides to para-Quinone Methides Leading to Meclizine-, Hydroxyzine- and Cetirizine-like Architectures." Synthesis 51, no. 23 (2019): 4434–42. http://dx.doi.org/10.1055/s-0039-1690677.

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An expeditious, cost-effective synthetic methodology for a wide range of nitrogen-containing unsymmetrical trisubstituted methanes (TRSMs) is reported. The synthesis involves base-mediated 1,6-conjugate addition of heterocyclic amines and amides to substituted para-quinone methides, giving the unsymmetrical TRSMs in moderate to very good yields (up to 83%) in one pot. The low cost, mild temperature, high atom economy and yields, easy scale-up and broad substrate scope are some of the salient features of this protocol. Further, the methodology could be extended for the synthesis of meclizine-,

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Bakovic, Marica. "Membrane biogenesis, nutrient transport, and natural health product characterization." Open Access Government 45, no. 1 (2025): 256–57. https://doi.org/10.56367/oag-045-11838.

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Membrane biogenesis, nutrient transport, and natural health product characterization Find out here about Dr. Bakovic, an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization. I, Dr. Bakovic, am an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization. My laboratory was the first to clone and elucidate the mammalian Pcyt2 gene and protein structure and function. This is an unexplored research area, and my group was uniquely positioned to initiate the f

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