Relevant bibliographies by topics / Mesenchymal stem cells derived Chondrogenic Autologous Treatment

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Mesenchymal stem cells derived Chondrogenic Autologous Treatment'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Mesenchymal stem cells derived Chondrogenic Autologous Treatment"

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Leal Reis, Inês, Bruna Lopes, Patrícia Sousa, et al. "Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept." Animals 13, no. 8 (2023): 1312. http://dx.doi.org/10.3390/ani13081312.

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Tendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine synovial membrane mesenchymal stem cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization, and application. These cells are
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Smith, John Kelly. "Exercise as an Adjuvant to Cartilage Regeneration Therapy." International Journal of Molecular Sciences 21, no. 24 (2020): 9471. http://dx.doi.org/10.3390/ijms21249471.

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This article provides a brief review of the pathophysiology of osteoarthritis and the ontogeny of chondrocytes and details how physical exercise improves the health of osteoarthritic joints and enhances the potential of autologous chondrocyte implants, matrix-induced autologous chondrocyte implants, and mesenchymal stem cell implants for the successful treatment of damaged articular cartilage and subchondral bone. In response to exercise, articular chondrocytes increase their production of glycosaminoglycans, bone morphogenic proteins, and anti-inflammatory cytokines and decrease their product
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Diomede, Francesca, Thangavelu Soundara Rajan, Marco D’Aurora, et al. "Stemness Characteristics of Periodontal Ligament Stem Cells from Donors and Multiple Sclerosis Patients: A Comparative Study." Stem Cells International 2017 (December 14, 2017): 1–14. http://dx.doi.org/10.1155/2017/1606125.

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Multiple sclerosis (MS) is the most prevalent and progressive autoimmune disease that affects the central nervous system, and currently, no drug is available for the treatment. Stem cell therapy has received substantial attention in MS treatment. Recently, we demonstrated the immunosuppressive effects of mesenchymal stem cells derived from neural crest-originated human periodontal ligament tissue (hPDLSCs) in an in vivo model of MS. In the present study, we comparatively investigated the stemness properties of hPDLSCs derived from healthy donors and relapsing-remitting MS patients. Stem cell m
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Muñoz-Criado, Ignacio, Jose Meseguer-Ripolles, Maravillas Mellado-López, et al. "Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis." Stem Cells International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/4758930.

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Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution. When infrapatellar- and supra
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Mata, Manuel, Lara Milian, Maria Oliver, et al. "In Vivo Articular Cartilage Regeneration Using Human Dental Pulp Stem Cells Cultured in an Alginate Scaffold: A Preliminary Study." Stem Cells International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8309256.

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Osteoarthritis is an inflammatory disease in which all joint-related elements, articular cartilage in particular, are affected. The poor regeneration capacity of this tissue together with the lack of pharmacological treatment has led to the development of regenerative medicine methodologies including microfracture and autologous chondrocyte implantation (ACI). The effectiveness of ACI has been shown in vitro and in vivo, but the use of other cell types, including bone marrow and adipose-derived mesenchymal stem cells, is necessary because of the poor proliferation rate of isolated articular ch
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Feng, Y., M. Zhu, S. Dangelmajer, et al. "Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer." Cell Death & Disease 5, no. 12 (2014): e1567-e1567. http://dx.doi.org/10.1038/cddis.2014.521.

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Abstract Adult human adipose-derived mesenchymal stem cells (hAMSCs) are multipotent cells, which are abundant, easily collected, and bypass the ethical concerns that plague embryonic stem cells. Their utility and accessibility have led to the rapid development of clinical investigations to explore their autologous and allogeneic cellular-based regenerative potential, tissue preservation capabilities, anti-inflammatory properties, and anticancer properties, among others. hAMSCs are typically cultured under ambient conditions with 21% oxygen. However, physiologically, hAMSCs exist in an environ
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Lubis, Andri Maruli Tua, Adrian Situmeang, Anissa Feby Canintika, et al. "Intra-articular injection of human umbilical cord-derived mesenchymal stem cells in sheep models of meniscectomy-induced osteoarthritis: An experimental study." Orthopaedic Journal of Sports Medicine 11, no. 2_suppl (2023): 2325967121S0091. http://dx.doi.org/10.1177/2325967121s00913.

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Introduction: Autologous mesenchymal stem cells (MSC) implantation suspended in hyaluronic acid (HA) has been proven to delay worsening of articular cartilage degeneration in the knee joint. This has been the treatment of choice for young patients with knee osteoarthritis (KOA); however, it is associated with morbidities such as requirement of multiple procedures, donor site morbidity and failure in achieving cultured cells with chondrogenic properties. Our study investigates the possibility of direct intra articular injection of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) f
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Francesco, Francesco De, Silvia Mannucci, Giamaica Conti, Elena Dai Prè, Andrea Sbarbati, and Michele Riccio. "A Non-Enzymatic Method to Obtain a Fat Tissue Derivative Highly Enriched in Adipose Stem Cells (ASCs) from Human Lipoaspirates: Preliminary Results." International Journal of Molecular Sciences 19, no. 7 (2018): 2061. http://dx.doi.org/10.3390/ijms19072061.

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Adipose tissue possesses phenotypic gene expression characteristics that are similar to human mesenchymal stem cells (hMSCs). Nevertheless, the multilineage potential may be inhibited, and cells may not expand adequately to satisfy the requirements of Good Manufacturing Practice (cGMP). An autologous hMSC-enriched fat product would fulfil the void from a biomedical and clinical perspective. In this study, we suggest a novel mechanism using a closed system without enzymes, additives or other modifications, which will produce non-expanded, accessible material. This decentralized fat product, unl
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Oliveros Anerillas, Luis, Paul J. Kingham, Mikko J. Lammi, Mikael Wiberg, and Peyman Kelk. "Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels." International Journal of Molecular Sciences 22, no. 24 (2021): 13594. http://dx.doi.org/10.3390/ijms222413594.

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Autologous bone transplantation is the principal method for reconstruction of large bone defects. This technique has limitations, such as donor site availability, amount of bone needed and morbidity. An alternative to this technique is tissue engineering with bone marrow-derived mesenchymal stem cells (BMSCs). In this study, our aim was to elucidate the benefits of culturing BMSCs in 3D compared with the traditional 2D culture. In an initial screening, we combined BMSCs with four different biogels: unmodified type I collagen (Col I), type I collagen methacrylate (ColMa), an alginate and cellul
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Miguelino, Maricel G., Christopher D. Pivetti, Lee Lankford, Jerry Sherman Powell, and Aijun Wang. "In Utero Chorionic Villus Stem Cell Transplantation for the Treatment of Hemophilia A." Blood 124, no. 21 (2014): 106. http://dx.doi.org/10.1182/blood.v124.21.106.106.

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Abstract Pregnancy epitomizes graft tolerance, where the intrauterine allogeneic fetus is protected from rejection by the maternal immune system. Fetal cells are able to enter the maternal circulation as early as six weeks of gestation, and persist for decades without graft rejection. We hypothesize that a window of opportunity exists prior to maturation of T cells where in utero transplantation of donor cells may be recognized as self, therefore inducing tolerance permissive for long term engraftment. Hemophilia A (HA) is an X-linked recessive coagulation disorder that results in bleeding dia
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Dissertations / Theses on the topic "Mesenchymal stem cells derived Chondrogenic Autologous Treatment"

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Bertoni, Lélia. "Évaluation du potentiel thérapeutique des cellules souches mésenchymateuses dans un modèle d'arthropathie expérimentale induite chez le cheval Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1 Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization Evaluation of allogeneic bone-marrow-derived and umbilical cord blood-derived mesenchymal stem cells to prevent the development of osteoarthritis in an equine model Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC417.

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’arthropathie dégénérative est une maladie ayant des répercussions socio-économiques majeures chez l’homme et le cheval. Il n’existe pour l’heure aucun traitement curatif de cette maladie, le cartilage articulaire étant dépourvu de pouvoir de cicatrisation spontané. De nombreux espoirs reposent sur l’utilisation de cellules souches mésenchymateuses (CSM), pour leur potentiel pro-régénératif et anti-inflammatoire. Le premier objectif de cette étude était d’évaluer la tolérance des CSM de sang de cordon ombilical (SCO) et de moelle osseuse (MO) dans des articulations saines. L’étude contrôlée en
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Book chapters on the topic "Mesenchymal stem cells derived Chondrogenic Autologous Treatment"

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Weiss, Jeffrey N. "Treatment of Tendon Disease Using Autologous Adipose-Derived Mesenchymal Stem Cells." In Orthopedic Stem Cell Surgery. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_9.

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Weiss, Jeffrey N. "Treatment of Knee Osteoarthritis with Autologous Adipose-Derived Mesenchymal Stem Cells." In Orthopedic Stem Cell Surgery. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_29.

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Weiss, Jeffrey N. "Treatment of Early Knee Osteoarthritis with Autologous Adipose-Derived Mesenchymal Stem Cells." In Orthopedic Stem Cell Surgery. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_24.

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Smaida, Rana, Henri Favreau, Moustafa Naja, et al. "Polycaprolactone Based Biomaterials and Sodium Hyaluronate Nanoreservoirs for Cartilage Regeneration." In Stem Cells and Regenerative Medicine. IOS Press, 2021. http://dx.doi.org/10.3233/bhr210018.

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Obstacles persist in the treatment and prevention of articular cartilage defects. Polycaprolactone (PCL) and poly(vinyl-pyrrolidone) (PVP) biomaterials were obtained by electrospinning and electrospraying to inspect their potential application for cartilage regeneration. Sodium hyaluronate (SH) was then added into nanofibers of PCL and particles of PVP. The aim of incorporating sodium hyaluronate to this polymer is to enhance the capacity of articular cartilage to regenerate. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were seeded onto these tissue engineering (TE) products. Th
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Joaquín Merino, José, María Gabriela Villalba, Ricardo Martínez-Murillo, and Ana I. Flores. "Mesenchymal Stem Cells from Fat: From Differentiation Mechanisms to Biomedical Application in Patients." In Stem Cell Transplantation [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1007734.

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Adipose tissue mesenchymal stem cells (AD-MSC or ADSC) are multipotent cells that do not show immune rejection. In this work, we analyze the route of administration and its possible differentiation into specific lineages of adipogenic, chondrogenic, osteogenic, myogenic, or neurogenic phenotypes. Transplanted cells induced tissue repair by inducing angiogenic, anti-inflammatory, and immunomodulatory effects (IDO, PG-2, nitric oxide, and some cytokine signaling). The ADSC exert these tissue repair processes through the release of chemokines and growth factors in a paracrine manner. Other fat-de
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Feng, Chunjing, Jean-Francois Stoltz, and Zhongchao Han. "Stem Cells: Novel Technologies, Therapies and Industrial Models." In Stem Cells and Regenerative Medicine. IOS Press, 2021. http://dx.doi.org/10.3233/bhr210007.

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Stem cells are a kind of cells with the ability of self-renewal and multi-directional differentiation potential. A variety of stem cells or progenitor cells have been shown to be efficacy in the treatment of some refractory diseases. The mesenchymal stem cells (MSCs) are derived from mesoderm and have the characteristics of differentiation into three germ layers and immune regulation, which means that these cells are suitable for either autologous or allogeneic treatment and are ideal cells for regenerative medicine. MSCs can be isolated from various tissue types, including the bone marrow, fa
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Conference papers on the topic "Mesenchymal stem cells derived Chondrogenic Autologous Treatment"

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Kim, Minwook, Isaac E. Erickson, Jason A. Burdick, George R. Dodge, and Robert L. Mauck. "Differential Chondrogenic Potential of Human and Bovine Mesenchymal Stem Cells in Agarose and Photocrosslinked Hyaluronic Acid Hydrogels." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19461.

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Articular cartilage has a limited regenerative capacity, and there exist no methodologies to restore structure and function after damage or degeneration. This has focused intense work on cell-based therapies for cartilage repair, with considerable literature demonstrating that chondrocytes in vitro and in vivo can generate cartilage-like tissue replacements. However, use of primary cells is limited by the amount and quality of autologous donor cells and tissue. Multipotential mesenchymal stem cells (MSCs) derived from bone marrow offer an alternative cell source for cartilage tissue engineerin
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Duarte, Gabriela Guy, Daniel Gonçalves de Oliveira, Felipe de Oliveira Breder, Guilherme Augusto Netto Nacif, and Ivan Magalhães Viana. "Efficacy of mesenchymal stem cells in the treatment of ischemic stroke." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.327.

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Background: Ischemic stroke is one of the main causes of long-term disability in adults. In the search for therapies for neurological sequelae after stroke, several studies have been investigating the use of stem cells, especially mesenchymal stem cells (MSC). Objectives: To evaluate the efficacy of stem cell therapy in patients with neurological deficits due to stroke. Methods: A literature review was conducted based on clinical studies published on PubMed and Cochrane databases between 2013 and 2021. The search strategy (mesenchymal stem cells) AND (stroke) was used and 4 articles were selec
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Kim, Minwook, Isaac E. Erickson, Jason A. Burdick та Robert L. Mauck. "Transient Exposure to TGF-β3 Improves the Functional Properties of MSC-Seeded Photocrosslinked Hyaluronic Acid Hydrogels". У ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53906.

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Articular cartilage is the primary compressive load bearing soft tissue in diarthrodial joints. While the tissue can function remarkably well in a demanding environment over a lifetime of use, focal defects and other trauma can initiate progressive degeneration. Cartilage tissue engineering approaches have been developed with the goal of forming biologic replacement materials with functional mechanical properties [1]. While chondrocytes are a popular cell source for such approaches, and can produce constructs with near-native functional properties [2], mesenchymal stem cells (MSCs) derived fro
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