Relevant bibliographies by topics / Mesenchymal Stromal Cellls / Dissertations / Theses
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Dissertations / Theses on the topic 'Mesenchymal Stromal Cellls'

Author: Grafiati
Published: 31 May 2025
Last updated: 31 July 2025

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1

Villard, Orianne. "Effets des cellules stromales pancréatiques immortalisées humaines sur les cellules bêta humaines." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT024.

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Introduction : L’efficacité de la greffe d’îlots n’est plus à démontrer mais elle reste l’objet de recherches pour améliorer la qualité et la survie des îlots greffés souvent fragilisés par la destruction enzymatique de leur microenvironnement lors de la procédure d’isolement. Dans ce contexte, les cellules stromales mésenchymateuses (CSM) d’origine pancréatique représentent un outil intéressant par leurs propriétés d’immunomodulation et par leur capacité de sécrétion de facteurs du microenvironnement. L’objectif de ce travail est d’évaluer l’effet des cellules stromales pancréatiques humaines
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2

Escobar, Pauline. "Rôle des chimiokines dans les interactions entre les cellules stromales mésenchymateuses et les cellules de cancer du sein." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T019.

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Le cancer du sein est le cancer le plus fréquent chez la femme et représente un problème de santé publique majeur. L'agressivité des tumeurs mammaires varie notamment en fonction de leurstatut pour le récepteur α des oestrogènes (ERα). Les cancers du sein n'exprimant pas ERα ont unmauvais pronostic, de part leur capacité métastatique plus importante. Cependant, les facteurs sous jacents à cette plus grande agressivité des cancers ERα-négatifs restent mal compris. Il est aujourd'hui admis que la progression tumorale et la dissémination métastatique dépendent, non seulement des propriétés intrin
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3

Nie, Yingjie, and 聶瑛潔. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells ascell-therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278681.

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4

PISCHIUTTA, FRANCESCA. "Mesenchymal stromal cells for traumatic brain injury." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52353.

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The multiple pathological cascades activated after traumatic brain injury (TBI) and their extended nature offer the possibility for therapeutic interventions possibly affecting multiple injury mechanisms simultaneously. Mesenchymal stromal cell (MSC) therapy matches this need, being a bioreactor of a variety of molecules able to interact and modify the injured brain microenvironment. Compared to autologous MSCs, bank stored GMP-graded allogenic MSCs appear to be a realistic choice for TBI in a translational perspective, due to the need of delivering cell therapy in the acute phase of the path
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5

Daniel, Matthieu. "Interactions neuro-immunitaires et rôle des cellules stromales mésenchymateuses au cours de la COVID-19." Electronic Thesis or Diss., La Réunion, 2024. http://www.theses.fr/2024LARE0045.

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Le virus responsable du « Severe Acute Respiratory Syndrome-CoronaVirus 2 » ou SARS-CoV-2, et de la maladie nommée COVID-19 est caractérisé, sur le plan clinique, par une atteinte des voies respiratoires. Cette atteinte semble représenter un des déterminants essentiels de la sévérité et de l'évolution clinique des patients infectés. Elle peut s'accompagner d'un tableau d'hypoxémie profonde nécessitant parfois le recours à la ventilation mécanique et pouvant mener au décès. Si cette atteinte respiratoire demeure la préoccupation principale des cliniciens, elle n'est pour autant pas la seule cib
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6

Nie, Yingjie. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells as cell-therapy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278681.

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7

Fung, Kwong-lam, and 馮廣林. "Chemoresistance induced by mesenchymal stromal cells on cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205639.

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Human mesenchymal stromal cells (hMSCs) are part of bone marrow micro-environment that supports hematopoiesis. However, hMSCs also enhance tumor progression and survival when they become part of the cancer micro-environment. I aimed to investigate the interaction between hMSCs and cancer cells during chemotherapy. Firstly, I studied the interaction between hMSCs and T-lineage acute lymphoblastic leukemia (T-ALL) cells under pegylated arginase I (BCT-100) treatment. Three T-ALL cell lines were sensitive to BCT-100 but not hMSCs. Conversely, hMSCs could partly protect all T-ALL cell lines fro
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8

Roux, Clémence. "Activité immunosuppressive des cellules stromales mésenchymateuses dérivées de cellules souches pluripotentes induites humaines : induction de lymphocytes T régulateurs in vitro et in vivo et expression de PD-L1." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4226/document.

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La grande originalité de mon projet réside dans la génération de cellules stromales mésenchymateuses (MSCs) à partir de cellules souches pluripotentes induites humaines (iPS). Je rappellerai les propriétés phénotypiques, de multipotence et immunosuppressives des MSCs et m’attarderai sur leurs différents mécanismes immunomodulateurs. Cependant, leur nombre limité et leur isolation difficile limitent leur utilisation thérapeutique nécessitant une autre source de cellules.Mon travail a donc été de générer et de caractériser des MSCs issues d’iPS (huiPS-MSCs). L'avantage des huiPS-MSCs réside dans
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9

Pasanen, I. (Ilkka). "Stromal cells of mesenchymal origin in breast cancer." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215587.

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Abstract Breast cancer, the most common cancer in women in Finland; its prognosis varies from very good to poor. During the last two decades, mesenchymal stromal cells, carcinoma-associated fibroblasts and normal fibroblasts of the breast have been investigated in the context of breast carcinomas because of their presence in the tumor microenvironment. It has been shown that the properties of the non-malignant tumor compartment possess prognostic value. The effects that these three stromal cell types have on cancer progression have been studied, but their exact mechanisms remain still largely
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10

Sory, David Roger Raymond. "Dynamic loading of periosteum-derived mesenchymal stromal cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59138.

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Explosive-generated waves exhibit high-energy loading profiles featured with mechanical characteristics applied over a wide range of strain rates. Recent decades have seen unprecedented occurrence of high-energy trauma associated with blast wave exposure. One such blast-specific pathology is blast-induced heterotopic ossification (bHO), which refers to ectopic bone formation due to inappropriate mesenchymal stromal cell (MSC) osteogenesis in non-skeletal tissues. Significant effort has been made into deciphering the molecular mechanisms that allow the onset of bHO, however little research has
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11

Ward, Lewis Stuart Corey. "Interactions of mesenchymal stromal cells with their microenvironment." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8278/.

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Mesenchymal stromal cells (MSC) suppress the inflammatory infiltrate through crosstalk with neighbouring endothelium. However, this response is lost at chronic inflammatory sites where stromal cells instead support leukocyte recruitment and upregulate expression of podoplanin. The mechanism and function by which this inflammatory phenotype is established is unknown. We hypothesise that MSC modulation of endothelium is also altered by exposure to inflammatory cytokines, and that expression of podoplanin confers an invasive phenotype, enabling the interaction of these perivascular MSC with circu
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CROCE, STEFANIA. "Mesenchymal stromal cells on bioscaffold for liver bioengineering." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1329186.

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Tissue bioengineering is the creation of functional tissues or whole organs by manufacturing body parts ex vivo, seeding cells on a supporting scaffold. The final goal of organ bioengineering is the use of the bioengineered organs as ‘replacement parts’ for the human body. The need for bioengineered livers is significant: currently, the only effective treatment for end-stage liver failure is orthotopic liver transplantation. However, the shortage of organ donors results every year in the death of many patients in the waiting list. Moreover, the advantage of this technology is the use of autolo
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13

Dhadda, Paramjeet Kaur. "Using mesenchymal stromal cells to improve islet transplantation outcome." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/using-mesenchymal-stromal-cells-to-improve-islet-transplantation-outcome(aef61279-a461-4023-8a23-7caceae29a1a).html.

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Pancreatic islet transplantation is an attractive treatment option for a subset of patients with Type 1 diabetes. However islet transplantation efficacy remains hampered by a number of factors, including the impaired quality of isolated islets available for transplantation and the loss of long-term islet function post transplantation. Harnessing the properties of multipotent mesenchymal stromal cells (MSCs), which can be derived from numerous clinically relevant post-natal tissues including adipose and pancreas, is currently under investigation for improving the survival of islet cells during
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14

Correia, Dos Reis Mónica Sofia. "Mesenchymal stromal cells : mode of action and clinical translation." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3456.

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Mesenchymal Stromal Cells (MSCs) are an extensively used cell type in clinical trials for the treatment of various diseases. In order to obtain clinically relevant numbers, MSCs need to be expanded in vitro, usually relying on the use of foetal calf serum (FCS), which is now not recommended by the regulatory authorities. In addition, the precise mechanism of action of MSCs remains unclear. The initial rationale for the therapeutic potential of MSCs was based on their engraftment and differentiation ability. It gets increasingly clear that MSCs exert their effects in a paracrine manner, by the
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15

Tsui, Yat-ping, and 徐軼冰. "Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197485.

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Myelin is essential for neuronal survival and maintenance of normal functions of the nervous system. Demyelinating disorders are debilitating and are often associated with failure of resident oligodendrocyte precursor cells (OPCs) to differentiate into mature, myelinating oligodendrocytes. Derivation of OPCs, from a safe source that evades ethical issues offers a solution to remyelination therapy. We therefore hypothesized that bone marrow stromal cells (BMSCs) harbour neural progenitor cells at a pre-commitment stage and that in vitro conditions can be exploited to direct differentiation of t
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16

Bayer, Wildberger Alexandra Clarissa. "Therapeutic approach for Myasthenia Gravis using conditioned mesenchymal stromal cells." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS528.pdf.

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Inflammatoires telles que l'interféron-γ (IFN-γ), qui peuvent altérer la physiologie et l'immunogénicité cellulaires. Notre équipe a développé une approche alternative consistant à co-cultiver les CSM avec des cellules mononucléées du sang périphérique (PBMC), et a montré que l’injection de cellules conditionnées de qualité recherche induit des améliorations cliniques dans un modèle murin humanisé (NSG-MG).Ici, dans une perspective clinique, nous avons d’abord validé l’utilisation de CSM de qualité clinique. Puis nous avons caractérisé l'expression génique et le profil phénotypique en comparan
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17

Caicedo, Andrès. "Communication cellule-cellule : transfert de mitochondries provenant des cellules souches/stromales mesenchymateuses (CSM) vers des cellules cancereuses." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T036.

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Au début de ma thèse, je me suis intéressé aux processus qui sous-tendent la communication cellulaire et plus spécifiquement les interactions cellule-cellule. Pourquoi une cellule établit-elle un contact spécifique avec une autre cellule ? Comment les cellules répondent-elles à cette interaction et quels en sont les effets ? J'ai utilisé comme modèle d'étude l'interaction entre les cellules souches/stromales mésenchymateuses (CSM) et des lignées de cancer du sein. L'objectif de mon travail a été d'analyser les mécanismes de ces interactions entre CSM et cellules cancéreuses et d'en évaluer les
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18

Jost, Camille. "Rôle du microenvironnement cellulaire de la mégacaryopoïèse." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ015/document.

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Les plaquettes sanguines ont comme rôle principal d’arrêter les saignements. Elles sont produites dans la moelle osseuse par des mégacaryocytes (MK) qui proviennent de la différenciation des cellules souches hématopoïétiques (CSH). L’objectif de ma thèse a été d’identifier les éléments cellulaires du microenvironnement contrôlant la mégacaryopoïèse. Mon travail a permis d’identifier une population particulière de progéniteurs hépatiques du foie foetal capable de promouvoir in vitro les étapes précoces de la mégacaryopoïèse à partir de CSH humaines et murines (Brouard et al., 2017). Le rôle des
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19

Loncaric, Darija. "Atténuation des oxydations phosphorylantes et induction d'une réponse cellulaire hypoxique : effêt de l'[alpha]-tocophérol-acétate et de miR-210 sur les cellules stromales mesenchymateuses." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0198.

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Dans cette thèse, nous avons combiné les approches des cultures single-cell, de cytométrie en flux,des analyses de métabolisme énergétique et de génétique moléculaire afin d’explorer les effets del’Acétate d’α-Tocopherol (α-TOA) sur les cellules stromales mésenchymateuses (MStroC) et leurs souspopulations fonctionnelles (cellules souches et progénitrices mésenchymateuses). L’autre but était de tester une molécule de miR-210 par rapport à son utilisation potentielle comme « hypoxia mimicking molecule ». Après avoir démontré l’hétérogénéité de la population MStroC et conclu que la population de
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Krasheninnikova, Maria Alieva. "Adipose tissue mesenchymal stromal cells as therapeutic vehicles against glioblastoma." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97086.

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Lately adipose tissue mesenchymal stem cells (hAMSCs) have emerged as cellular vehicles for therapy of solid tumors, due to their ease of isolation and manipulation, and wound/tumor homing capacity. HAMSCs have been successfully used in suicide gene therapy, employing the prodrug activating system based on Herpes simplex virus type I thymidine kinase (HSV-TK)/ganciclovir (GCV). In the current study we demonstrate an effective model of glioblastoma therapy based on the use of genetically modified hAMSCs and in vivo monitoring of tumor and therapeutic cells. Due to the capacity of photons to pa
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21

Lenz, Daniel. "Dissecting the heterogeneity of murine mesenchymal bone marrow stromal cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21017.

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Knochenmarks-Stromazellen sind in den letzten Jahren in den Fokus der Forschung gerückt. Es konnte gezeigt werden, dass sie durch Bereitstellung von Überlebenssignalen essenziell für die Erhaltung hämatopoetischer Nischen sind. Stromales Interleukin-7 (IL-7) konnte dabei für T Zellen als Überlebenssignal identifiziert werden. Gemeinsam ist allen Stromazellen die Expression des Oberflächenmarkers CD106/VCAM-1. Ein effizientes Protokoll erlaubte die qualitative wie quantitative Isolation von Stromazellen aus dem murinen Knochenmark mit anschließender ex vivo Microarray-Analyse. Die auf diese We
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Roux, Clémence. "Activité immunosuppressive des cellules stromales mésenchymateuses dérivées de cellules souches pluripotentes induites humaines : induction de lymphocytes T régulateurs in vitro et in vivo et expression de PD-L1." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4226.

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La grande originalité de mon projet réside dans la génération de cellules stromales mésenchymateuses (MSCs) à partir de cellules souches pluripotentes induites humaines (iPS). Je rappellerai les propriétés phénotypiques, de multipotence et immunosuppressives des MSCs et m’attarderai sur leurs différents mécanismes immunomodulateurs. Cependant, leur nombre limité et leur isolation difficile limitent leur utilisation thérapeutique nécessitant une autre source de cellules.Mon travail a donc été de générer et de caractériser des MSCs issues d’iPS (huiPS-MSCs). L'avantage des huiPS-MSCs réside dans
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23

Bertheuil, Nicolas. "Le tissu adipeux : approfondissement des connaissances fondamentales du tissu et de son compartiment vasculaire stromal, intérêt clinique pour la chirurgie plastique." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B051/document.

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L’objectif de cette thèse était d’améliorer les connaissances fondamentales sur le tissu adipeux, organe qui est au cœur de la pratique des chirurgiens plasticiens. En effet, ce tissu peut être transplanté de façon autologue afin de combler une perte de substance (rôle volumateur des adipocytes) mais également servir à des fins de régénération tissulaire en lien avec les cellules de la fraction vasculaire stromale (FVS) et tout particulièrement des cellules stromales mésenchymateuses (CSM). Ces cellules s’obtiennent après lipoaspiration du tissu par une digestion enzymatique de la graisse obte
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GORGUN, CANSU. "Functional Characterization of Mesenchymal Stromal Cell- Derived Extracellular Vesicles." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1044371.

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Mesenchymal Stromal Cells (MSCs) are currently considered a powerful tool for the treatment of multiple diseases. Indeed, the original hypothesis underlying MSC based regenerative therapies was based on functional recovery as a consequence of stem cell differentiation. But it is now clear that other mechanisms of action are involved. The recent emerging paradigm shift suggests that the paracrine effects of MSCs may be as important as cell differentiation in eliciting functional tissue repair. Among the factors responsible for the paracrine effects, extracellular vesicles (EVs) have been recent
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Mebarki, Miryam. "Evaluation des mécanismes d’action des cellules stromales mésenchymateuses pour l’optimisation de la régénération osseuse : impact des biomatériaux et de l’hétérogénéité des donneurs." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0086.

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Le tissu osseux a la capacité de se régénérer suite à une fracture. Cependant, des consolidations incomplètes concernent aujourd’hui environ un million de personnes par an. L’approche d’ingénierie tissulaire associant des cellules stromales mésenchymateuses (CSM) à des biomatériaux émerge comme une stratégie prometteuse pour réparer ces défauts. Par ailleurs, l’efficacité de la régénération osseuse semble varier en fonction du donneur mais aussi du support associé. L’objectif de mon travail de thèse a été de comprendre les mécanismes à l’origine de ces variabilités. Pour cela, nous nous sommes
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Menneteau, Thomas. "Développement de méthodes de spectrométrie de masse pour l'étude de la dynamique des complexes de protéasome : application aux cellules stromales/souches mésenchymateuses humaines." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30234.

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Les protéines sont des biomolécules majeures dans l'ensemble des processus cellulaires. La régulation fine de leur concentration est donc essentielle dans la survie et le développement d'une cellule et peut avoir lieu en amont ou en aval de leur synthèse. Un des systèmes cellulaires capable de dégrader les protéines est le système Ubiquitine-Protéasome. Le protéasome 26S, élément central de ce système, est composé d'un cœur catalytique, le protéasome 20S et d'une particule activatrice, le régulateur 19S. Le protéasome 20S est un complexe multiprotéique présentant une très grande diversité stru
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Rae, Michelle C. "An investigation into the immuno-modulatory properties of mesenchymal stromal cells." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506524.

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OPINATO, VIVIANA MARIA. "Role of Mesenchymal Stromal Cells in High-Grade Serous Ovarian Cancer." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2924766.

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Mesenchymal Stromal Cells (MSCs) are the precursors of various cell types that compose both normal and cancer tissue microenvironments. In order to support the widely diversified parenchymal cells and tissue organization, MSCs are characterized by a large degree of heterogeneity, although available analysis of molecular and transcriptional data do not provide any clear evidence. Moreover, a wealth of study has demonstrated a significant role of the microenvironment and MSCs in tumor growth. In the laboratory in which I carried out my PhD project, MSCs were purified from different healthy tissu
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Zhou, Yinghong. "Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63002/1/Yinghong_Zhou_Thesis.pdf.

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The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.
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Queiroz, Diana Leocata de. "Transplante intratecal de células estromais mesenquimais multipotentes em equinos através do espaço intervertebral C1-C2." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152240.

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Submitted by Diana Leocata de Queiroz null (diana_leocata@hotmail.com) on 2017-12-04T13:26:05Z No. of bitstreams: 1 TRANSPLANTE INTRATECAL DE CÉLULAS ESTROMAIS MESENQUIMAIS MULTIPOTENTES EM EQUINOS ATRAVÉS DO ESPAÇO INTERVERTEBRAL C1-C2 finalf.pdf: 1646738 bytes, checksum: b542c7fc14354a10598a5cdea4680f6b (MD5)<br>Submitted by Diana Leocata de Queiroz null (diana_leocata@hotmail.com) on 2017-12-04T14:43:24Z No. of bitstreams: 1 TRANSPLANTE INTRATECAL DE CÉLULAS ESTROMAIS MESENQUIMAIS MULTIPOTENTES EM EQUINOS ATRAVÉS DO ESPAÇO INTERVERTEBRAL C1-C2 finalf.pdf: 1646738 bytes, checksum: b542c7
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Petrella, Francesco. "EXPERIMENTAL AND CLINICAL AIRWAY RESTORATION BY MESENCHYMAL STROMAL CELLS AUTOLOGOUS ENDOSCOPIC TRANSPLANTATION." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3421925.

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Post resectional broncho-pleural fistula is a pathological connection between the airways and the pleural space that may develop after lung resection. It may be caused by incomplete bronchial closure, impediment of bronchial stump wound healing, or stump destruction by residual neoplastic tissue; its mortality ranges from 12.5 to 71.2%, therefore it is still the most feared complication after curative lung resection; for this reason the healing effects promoted by stem cells – by transformation into mature cells with a specialized function or by enhancing intrinsic repair mechanisms –may repre
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Martinaud, Christophe. "Anomalies moléculaires et fonctionnelles des cellules stromales mésenchymateuses de patients atteints de myélofibrose primitive : altérations « intrinsèques » de leur différenciation ostéoblastique." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T099.

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La myélofibrose primitive (MFP) est un néoplasme myéloprolifératif chromosome Philadelphie négatif rare, mais de pronostic sévère. Elle se caractérise par une prolifération clonale et une mobilisation des cellules souches et progéniteurs hématopoïétiques (CSH/PH) de la moelle osseuse vers la rate et le foie. Cette anomalie de l’hématopoïèse est associée à une pathologie du stroma (myélofibrose, ostéosclérose et néoangiogenèse). L’existence d’anomalies moléculaires de la CSH/PH telles que les mutations de Jak2, Mpl, TET2 ou CALR ne permet pas à elle seule d’expliquer la physiopathologie de la m
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Refeyton, Alice. "La survie et les adaptations métaboliques des cellules primitives mésenchymateuses et hématopoïétiques en anoxie et anoxie/aglycémie." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0028.

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Les cellules stromales mésenchymateuses (CStroM) comprennent des cellules souches (CS) multipotentes capables de régénérer des tissus lésés par des agressions de type ischémique. Pourtant, une mortalité élevée des CStroM après transplantation est mise en évidence lors de leur prise de greffe. Par conséquent, explorer les stratégies visant à améliorer la viabilité des greffes cellulaires constitue le défi de la thérapie cellulaire. À cette fin, nous avons effectué des analyses fonctionnelles et métaboliques sur deux types de population différents contenant des CS somatiques : des CStroM et une
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Bown, Andre B. J. "The Utilization of Multipotent Mesenchymal Stromal Cell Transplantation to Improve Fascia Repair." Youngstown State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1376390936.

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Roggel, Florian [Verfasser]. "Ultrasonographische und histologische Untersuchungen von künstlich erzeugten und mit kultivierten mesenchymalen stromalen Zellen aus Fettgewebe (Adipose Tissue Mesenchymal Stromal Cells, AT-MSCs) behandelten Läsionen der oberflächlichen Beugesehne bei Pferden / Florian Roggel." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037878078/34.

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Päbst, Felicitas Miriam Thekla. "Oberflächenentigen- und Sehnenmarkerexpression equiner multipotenter mesenchymaler Stromazellen." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-202786.

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1. Einleitung Multipotente mesenchymale Stromazellen (MSC) stellen eine interessante Therapieoption in der regenerativen Medizin verschiedener Erkrankungen dar. Aufgrund ihrer Herkunft aus mesodermalem Gewebe ist ihr Einsatz in der Therapie von Sehnenerkrankungen als günstig anzusehen, wo sie bei Pferden bereits erfolgreich verwendet werden. Da dieser Erkrankungskomplex mit degenerativen Veränderungen der Achillessehne des Menschen vergleichbar ist, wäre eine Translation der gewonnenen Ergebnisse in die Humanmedizin wünschenswert. Die zugrunde liegenden Wirkmechanismen bei der Sehnenregenerati
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Huang, Gang [Verfasser]. "Impact of mesenchymal stromal cells on streptozotocin-induced diabetic cardiomyopathy / Gang Huang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1180387996/34.

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Roberts, Samantha. "PECAM-1 expression by mesenchymal stromal cells is regulated by Notch signalling." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/pecam1-expression-by-mesenchymal-stromal-cells-is-regulated-by-notch-signalling(1259846d-df3b-43c3-8ce0-d25135ccdedd).html.

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Mesenchymal stromal cells (MSCs) reside within the perivascular niche and have been shown in vivo to facilitate vascular repair. Previous in vitro studies, have demonstrated the potential of MSCs to differentiate towards an endothelial lineage, when cultured at high cell density; but the characterisation of these cells and the mechanisms directing this important differentiation effect are ill-defined. To resemble a three-dimensional (3D) cellular environment, MSCs were cultured as spheroids and the endothelial characteristics of these cells determined. MSCs cultured as spheroids significantly
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Nili, Ahmadabadi Elham. "Development of a novel mesenchymal stromal cell (MSC) therapy for repairing the cornea." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122897/1/Elham_Nili%20Ahmadabadi_Thesis.pdf.

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This thesis has produced advances in our understanding of the biology and potential clinical application of stem cells to aid the treatment of patients with severe eye injuries. This research evaluated the therapeutic potential of a stem cell (called Mesenchymal Stromal Cells (MSCs)) isolated from the peripheral margin of the cornea, known as the limbus. Firstly, a method for routinely isolation and propagation of human limbal MSCs was optimized. Subsequently, the performance of those cells on a silk fibroin membrane was examined.
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Bray, Laura Jane. "Evaluation of fibroin-based scaffolds for ocular tissue reconstruction." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/52665/1/Laura_Bray_Thesis.pdf.

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The epithelium of the corneolimbus contains stem cells for regenerating the corneal epithelium. Diseases and injuries affecting the limbus can lead to a condition known as limbal stem cell deficiency (LSCD), which results in loss of the corneal epithelium, and subsequent chronic inflammation and scarring of the ocular surface. Advances in the treatment of LSCD have been achieved through use of cultured human limbal epithelial (HLE) grafts to restore epithelial stem cells of the ocular surface. These epithelial grafts are usually produced by the ex vivo expansion of HLE cells on human donor amn
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Upchurch, David A. "Administration of adipose-derived stromal vascular fraction and platelet rich plasma in dogs with coxofemoral osteoarthritis." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/19769.

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Master of Science<br>Department of Clinical Sciences<br>Walter Renberg<br>Objective: To evaluate the safety and effect of a single simultaneous intra-articular and intravenous injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet rich plasma (PRP) on coxofemoral osteoarthritis (OA) in dogs. Methods: This was a randomized, double-blind, placebo-controlled prospective pilot trial of simultaneous intra-articular and intravenous SVF and PRP for coxofemoral OA. Dogs with coxofemoral OA causing signs of lameness or discomfort were evaluated by orthopedic exam, visua
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Munshi, Afnan M. N. Alam. "Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39538.

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Bronzini, Ilaria. "A comprehensive study of adult stromal cells derived from mesenchymal tissues and their application in tendon regeneration." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422082.

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This research project focused on study of adult stromal cells derived from equine and canine mesenchymal tissue and the application of these cell sources in musculoskeletal injuries, particularly in tendon repair. Adult MSCs gained general attention in both human and veterinary medicine, however despite the advances in this field, much studies are needed in order to better understand MSCs behavior. With this goal the following research project focused on: - A comprehensive characterization and study in vitro of mesenchymal stromal cells derived from peripheral blood of horses (ePB-MSCs) and f
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CASTELLI, MONICA. "INCREASED SURVIVAL OF CLL B CELLS IN THE PRESENCE OF MARROW MESENCHYMAL STROMAL CELLS: A NOVEL MODEL TO DEFINE NEW TARGETS FOR THERAPY." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424459.

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Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western World, accounting for about 30% of adult leukemia, and it is characterized by the clonal expansion and accumulation of mature CD19+/CD5+/CD23+ B lymphocytes in the peripheral blood, bone marrow and secondary lymphoid organs. Despite their apparent longevity in patients, in vitro CLL leukemic B cells rapidly undergo spontaneous apoptosis. The selective survival advantage is due both to intrinsic defects on apoptosis mechanism and to signals delivered by accessory cells at the active site of the disease. Previous studi
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François, Moïra. "Comprehensive study of the immunomodulatory properties of bone marrow-derived mesenchymal stromal cells." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103683.

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Over the course of the last decade, mesenchymal stromal cells (MSC) have made a remarkable entry in the field of cell-based immunotherapy. In vitro, MSC were shown to modulate the immune response, either by acting as an immunosuppressant on several immune cells, or upon IFN-γ stimulation, as an antigen presenting cell (APC) for the priming of CD4+ T cells. Although a vast array of in vivo experiments in animals and humans has undeniably proven the immunological properties of MSC, the exact mechanisms by which MSC mediate their effects remain unclear. In Chapter 1, I presented a succinct review
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Amann, Elisa Maria [Verfasser]. "Immunomodulatory and regenerative effects of mesenchymal stromal cells in trauma / Elisa Maria Amann." Ulm : Universität Ulm, 2019. http://d-nb.info/1197692819/34.

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Bader, Andreas Matthäus [Verfasser]. "Molecular mechanisms of cardioprotection by cord blood mesenchymal stromal cells / Andreas Matthäus Bader." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1100387854/34.

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Espig, Sandy [Verfasser]. "Isolation and characterization of rat bone-marrow derived mesenchymal stromal cells / Sandy Espig." Ulm : Universität Ulm. Medizinische Fakultät, 2016. http://d-nb.info/1082294284/34.

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Burk, Janina, Claudia Gittel, Sandra Heller, et al. "Gene expression of tendon markers in mesenchymal stromal cells derived from different sources." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-157823.

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Background: Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the MSC source on their properties relevant to tendon regeneration. The aim of this study was to assess and compare the expression of tendon extracellular matrix proteins and tendon differentiation markers in MSC derived from different sources as well as in native tendon tissue. MS
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Badraiq, Heba Ghazi O. "Effects of maternal body weight on Wharton's Jelly mesenchymal stromal cells (pilot study)." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/effects-of-maternal-body-weight-on-whartons-jelly-mesenchymal-stromal-cells-pilot-study(dac6be9c-1f9d-4c00-88dc-2a73ec4489b4).html.

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To investigate whether the maternal metabolic environment affects the DNA methylation of mesenchymal stromal/stem cells (MSCs) from umbilical cord (UC) Wharton’s Jelly (WJ), potentially rendering them unsuitable for clinical use in multiple recipients, a pilot study was conducted on fourteen UCs obtained post partum from healthy non-obese (BMI=19-25; n=7) and obese (BMI≥30; n=7) donors receiving elective Caesarean sections. The time of first WJ-MSCs outgrowth from UC explants was similar in samples from obese and non-obese donors. However, the cells from non-obese donors proliferated faster af
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