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Journal articles on the topic 'Mesenchymal Stromal Cellls'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Tian, Chen, Guoguang Zheng, M. James You, and Yizhuo Zhang. "Microrna-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells." Blood 128, no. 22 (2016): 1576. http://dx.doi.org/10.1182/blood.v128.22.1576.1576.

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Abstract Acute myeloid leukemia (AML) is not sensitive to chemotherapy partially because of the protection of AML cells by mesenchymal stromal cells (MSCs). Our previous studies found that MSCs protected AML cells from apoptosis through the c-Myc-dependent pathway. However, the mechanism by which MSCs regulate c-Myc in AML cells is still unknown. To elucidate the mechanism, we performed microRNA array analysis of AML cell lines and validated by TaqMan realtime PCR. The results showed that the expression of microRNA-494 (miR-494) in AML cells after coculture with MSCs was down-regulated. Report

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Srinivas, Ampati. "The Constantly Highly Expression of Limbal Stromal Cells Compared to the Bone Marrow Mesenchymal Stromal Cells, Adipose-Derived Mesenchymal Stromal Cells and Foreskin Fibroblasts." Stem Cells Research and Therapeutics International 1, no. 1 (2019): 01–06. http://dx.doi.org/10.31579/2643-1912/005.

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Tarusin, D. "ENCAPSULATION OF MESENCHYMAL STROMAL CELLS IN ALGINATE MICROSPHERES." Biotechnologia Acta 9, no. 4 (2016): 58–66. http://dx.doi.org/10.15407/biotech9.04.058.

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Pakula, Hubert, Ryan Carelli, Nicolo Fanelli, et al. "Abstract 3816: Functional atlas of prostate mesenchyme." Cancer Research 82, no. 12_Supplement (2022): 3816. http://dx.doi.org/10.1158/1538-7445.am2022-3816.

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Abstract Prostate cancer has a heterogeneous prognosis, and genetic alterations alone do not fully explain clinical behavior. We previously characterized the stroma of localized human prostates by Laser Capture Microdissection, and found that stroma was substantially different in prostates with and without tumor. Furthermore, a stromal gene signature reflecting bone remodeling was upregulated in high compared to low Gleason grade cases. To determine how stromal cells contribute to carcinogenesis and progression we study whether specific genetic alterations in the epithelium induce unique strom

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del Carmen Rodríguez, María, Antonio Bernad, and Miguel Aracil. "Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support." Blood 103, no. 9 (2004): 3349–54. http://dx.doi.org/10.1182/blood-2003-10-3438.

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Abstract Interleukin-6 (IL-6) is a critical factor in the regulation of stromal function and hematopoiesis. In vivo bromodeoxyuridine incorporation analysis indicates that the percentage of Lin-Sca-1+ hematopoietic progenitors undergoing DNA synthesis is diminished in IL-6-deficient (IL-6-/-) bone marrow (BM) compared with wild-type BM. Reduced proliferation of IL-6-/- BM progenitors is also observed in IL-6-/- long-term BM cultures, which show defective hematopoietic support as measured by production of total cells, granulocyte macrophage-colony-forming units (CFU-GMs), and erythroid burst-fo

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Zorin, V. L., and A. I. Zorina. "To the 90th year of Alexandr Jakovlevich Friedenstein." Genes & Cells 9, no. 3 (2014): 8–10. http://dx.doi.org/10.23868/gc120254.

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The article is dedicated to the outstanding Russian scientist A.J. Friedenstein, a founder of the hematopoietic organs' stroma doctrine, a discoverer of mesenchymal stem cells (multipotent mesenchymal stromal cells, MMSC), an initiator of the tests to determine the «verity» of stem stromal cells. Discoveries of the scientist and scientific school he created are used both in the research and clinical practice all over the world.

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Kondratyuk, Roman B., Ilya S. Grekov, and Evgenii A. Seleznev. "Microenvironment influence on the development of epithelial-mesenchymal transformation in lung cancer." RUDN Journal of Medicine 26, no. 3 (2022): 325–37. http://dx.doi.org/10.22363/2313-0245-2022-26-3-325-337.

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Relevance. Epithelial-mesenchymal transformation (EMT) largely determines the biological behavior and prognosis of cancers of various localizations. It is known that the determining role in the control and implementation of the transition of the epithelial phenotype to the mesenchymal belongs to the microenvironment. At the same time, the histochemical and microscopic characteristics of stromal elements remain unclear; therefore, the aim of our study was to establish the morphological features of the stroma that affect the development of EMT in lung cancer. Materials and Methods. We studied 32

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Ratushnyy, A. Yu, та L. B. Buravkova. "ПОТЕНЦИАЛ К ДИФФЕРЕНЦИРОВКЕ МЕЗЕНХИМАЛЬНЫХ СТРОМАЛЬНЫХ КЛЕТОК ПРИ РЕПЛИКАТИВНОМ СТАРЕНИИ". Aerospace and Environmental Medicine 56, № 4 (2022): 64–69. http://dx.doi.org/10.21687/0233-528x-2022-56-4-64-69.

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Mesenchymal stromal/stem cells (MSCs) are capable of multilinear differentiation and participate in tissue homeostasis including the remodeling and reparation processes. With aging these cells more and more often activatesenescence (cell aging) that alters cell functions and microenvironment which can be the reason for age-related pathologies. One of the features of senescent MSCs is thought to be a decline of multipotency that may limit their reparative functions in tissues. The paper presents a study of the MSCs osteogenic and adipogenic potential during replicative senescence. A decline of

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Petrella, Francesco, Isabella Rimoldi, Stefania Rizzo, and Lorenzo Spaggiari. "Mesenchymal Stromal Cells for Antineoplastic Drug Loading and Delivery." Medicines 4, no. 4 (2017): 87. http://dx.doi.org/10.3390/medicines4040087.

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Mesenchymal stromal cells are a population of undifferentiated multipotent adult cells possessing extensive self-renewal properties and the potential to differentiate into a variety of mesenchymal lineage cells. They express broad anti-inflammatory and immunomodulatory activity on the immune system and after transplantation can interact with the surrounding microenvironment, promoting tissue healing and regeneration. For this reason, mesenchymal stromal cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Another clinical application of mesenchymal s

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Cammarota, Francesca, and Mikko O. Laukkanen. "Mesenchymal Stem/Stromal Cells in Stromal Evolution and Cancer Progression." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/4824573.

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The study of cancer biology has mainly focused on malignant epithelial cancer cells, although tumors also contain a stromal compartment, which is composed of stem cells, tumor-associated fibroblasts (TAFs), endothelial cells, immune cells, adipocytes, cytokines, and various types of macromolecules comprising the extracellular matrix (ECM). The tumor stroma develops gradually in response to the needs of epithelial cancer cells during malignant progression initiating from increased local vascular permeability and ending to remodeling of desmoplastic loosely vascularized stromal ECM. The constant

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Bajaj, Anubha. "Interceding and Metamorphosed- Endometrial Stromal Sarcoma." Cell & Cellular Life Sciences Journal 8, no. 1 (2023): 1–4. http://dx.doi.org/10.23880/cclsj-16000180.

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Endometrial stromal sarcoma manifests as an infrequently discerned, malignant, high grade uterine mesenchymal neoplasm originating from endometrial stroma and composed of spherical or spindle shaped cells.

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Bhatia, R., PB McGlave, GW Dewald, BR Blazar, and CM Verfaillie. "Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages." Blood 85, no. 12 (1995): 3636–45. http://dx.doi.org/10.1182/blood.v85.12.3636.bloodjournal85123636.

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The bone marrow microenvironment supports and regulates the proliferation and differentiation of hematopoietic cells. Dysregulated hematopoiesis in chronic myelogenous leukemia (CML) is caused, at least in part, by abnormalities in CML hematopoietic progenitors leading to altered interactions with the marrow microenvironment. The role of the microenvironment itself in CML has not been well characterized. We examined the capacity of CML stroma to support the growth of long-term culture-initiating cells (LTC-IC) obtained from normal and CML marrow. The growth of normal LTC-IC on CML stroma was s

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Heyman, E., B. Devriendt, D. Elly, and C. De Schauwer. "Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS." Cytotherapy 25, no. 6 (2023): S61. http://dx.doi.org/10.1016/s1465-3249(23)00233-5.

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Nemeth, Michael, та David Bodine. "β-Catenin Expression in Cultured Bone Marrow Stromal Cells Is Required To Maintain Production of Osteoblasts and Hematopoietic Progenitor Cells." Blood 108, № 11 (2006): 85. http://dx.doi.org/10.1182/blood.v108.11.85.85.

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Abstract The canonical Wnt signaling pathway is defined by Wnt ligand-mediated stabilization and nuclear translocation of β-catenin to induce target gene expression. This pathway has been demonstrated to regulate differentiation of mesenchymal tissue, which includes the cell types (e.g. osteoblasts, myofibroblasts, adipocytes) that comprise the stromal cells of the hematopoietic microenvironment. We hypothesized that loss of canonical Wnt signaling would result in disruption of the ability of stromal cells to support hematopoiesis. To test this hypothesis, we generated transgenic mice that exp

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GRIFFITH, M., and M. RAFAT. "Corneal Stromal Mesenchymal Stem Cells for Corneal Stroma Reconstruction." Acta Ophthalmologica 89, s248 (2011): 0. http://dx.doi.org/10.1111/j.1755-3768.2011.3374.x.

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Wilson, Steven E. "The Yin and Yang of Mesenchymal Cells in the Corneal Stromal Fibrosis Response to Injury: The Cornea as a Model of Fibrosis in Other Organs." Biomolecules 13, no. 1 (2022): 87. http://dx.doi.org/10.3390/biom13010087.

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Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors to stromal fibrosis after injury to the cornea. Corneal fibroblasts, in addition to being major progenitors to myofibroblasts, also have anti-fibrotic functions in (1) the production of non-basement membrane collagen type IV that binds activated transforming growth factor (TGF) beta-1 and TGF beta-2 to downregulate TGF beta effects on cells in the injured stroma, (2) the production of chemokines that modulate the entry o

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Plava, Jana, Marina Cihova, Monika Burikova, et al. "Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy." Cells 9, no. 2 (2020): 480. http://dx.doi.org/10.3390/cells9020480.

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During cancer progression, breast tumor cells interact with adjacent adipose tissue, which has been shown to be engaged in cancer aggressiveness. However, the tumor-directed changes in adipose tissue-resident stromal cells affected by the tumor–stroma communication are still poorly understood. The acquired changes might remain in the tissue even after tumor removal and may contribute to tumor relapse. We investigated functional properties (migratory capacity, expression and secretion profile) of mesenchymal stromal cells isolated from healthy (n = 9) and tumor-distant breast adipose tissue (n

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Ronnov-Jessen, L., O. W. Petersen, and M. J. Bissell. "Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction." Physiological Reviews 76, no. 1 (1996): 69–125. http://dx.doi.org/10.1152/physrev.1996.76.1.69.

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Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of embryonic development and direct the coordinated organogenesis, correct spatial orientation, and the timely expression of functional activity consistent with physiological demands. The mesenchymal equivalent in the adult organism is the stroma, i.e., the loose connective tissue that is separated from the epithelial compartment by an intact basement membrane. In carcinomas, the cellular organization is dramatically changed, and the stroma is extensively modified. The basement membrane is penetrated in a process

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Patterson, Amanda L., Jamieson Pirochta, Stephanie Y. Tufano та Jose M. Teixeira. "Gain-of-function β-catenin in the uterine mesenchyme leads to impaired implantation and decidualization". Journal of Endocrinology 233, № 1 (2017): 119–30. http://dx.doi.org/10.1530/joe-16-0502.

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Embryo implantation and endometrial decidualization are critical events that occur during early pregnancy in humans and mice, and perturbation in either can result in infertility. WNT signaling through the canonical β-catenin pathway plays a pivotal role in embryonic Müllerian duct development, postnatal uterine maturation and establishment of pregnancy. Loss of β-catenin in the Müllerian duct mesenchyme (MDM)-derived stroma and myometrium results in impaired decidualization and infertility, whereas gain-of-function (GOF) results in the formation of mesenchymal tumors and sub-fertility attribu

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Golshahi, Hannaneh, Abbas Tavasoly, Annahita Rezaie, and Mohammad Farhadi. "Urokinase plasminogen activator expression in canine malignant mammary tumours by immunohistochemical study." Bulletin of the Veterinary Institute in Pulawy 57, no. 4 (2013): 587–91. http://dx.doi.org/10.2478/bvip-2013-0100.

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Abstract Immunohistochemical expression of urokinase plasminogen activator (uPA) was studied in 37 canine malignant mammary tumours to define the relationship between their histopathological type and grade. In 29 (78.4%) cases, expression of uPA by neoplastic cells was more than 10% and in 34 samples (91.9%) uPA expression by stromal cells (fibroblasts) was more than 10%. The uPA was expressed in epithelial and myoepithelial cells of carcinomas and carcinosarcomas and mesenchymal population of carcinosarcoma, chondrosarcoma, and carcinomas arising in benign tumours. The intensity and percentag

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Raman, Rachna, Ashwini Hinge, Rupali Kumar, Juying Xu, Kathleen Szczur, and Marie-Dominique Filippi. "P190-B RhoGAP Is Critical for Hematopoietic Stem Cell Niche Regulation." Blood 118, no. 21 (2011): 221. http://dx.doi.org/10.1182/blood.v118.21.221.221.

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Abstract Abstract 221 Hematopoiesis is regulated by components of the stromal microenvironment, so-called niche. Although the concept of hematopoietic stem and progenitor cell (HSC/P) niche is well known, its molecular regulation remains ill-defined. Here, we provide evidence that p190-B GTPase Activating Protein (p190-B), a negative regulator of Rho activity, is a regulator of mesenchymal/stromal cell functions necessary for normal hematopoiesis during fetal development. Mice lacking p190-B die before birth. At day 14.5 post coitum, p190-B−/− embryos are paler than WT embryos with a 40% lower

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Tripodo, Claudio, Sabina Sangaletti, Carla Guarnotta, et al. "Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion." Blood 120, no. 17 (2012): 3541–54. http://dx.doi.org/10.1182/blood-2011-12-398537.

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Abstract In myeloid malignancies, the neoplastic clone outgrows normal hematopoietic cells toward BM failure. This event is also sustained by detrimental stromal changes, such as BM fibrosis and osteosclerosis, whose occurrence is harbinger of a dismal prognosis. We show that the matricellular protein SPARC contributes to the BM stromal response to myeloproliferation. The degree of SPARC expression in BM stromal elements, including CD146+ mesenchymal stromal cells, correlates with the degree of stromal changes, and the severity of BM failure characterizing the prototypical myeloproliferative n

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Barnhoorn, M. C., S. K. Hakuno, R. S. Bruckner, G. Rogler, L. J. A. C. Hawinkels, and M. Scharl. "Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease." Journal of Crohn's and Colitis 14, no. 7 (2020): 995–1009. http://dx.doi.org/10.1093/ecco-jcc/jjaa009.

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Abstract Up till now, research on inflammatory bowel disease [IBD] has mainly been focused on the immune cells present in the gastrointestinal tract. However, recent insights indicate that stromal cells also play an important and significant role in IBD pathogenesis. Stromal cells in the intestines regulate both intestinal epithelial and immune cell homeostasis. Different subsets of stromal cells have been found to play a role in other inflammatory diseases [e.g. rheumatoid arthritis], and these various stromal subsets now appear to carry out also specific functions in the inflamed gut in IBD.

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Zuk, Patricia A., Min Zhu, Peter Ashjian, et al. "Human Adipose Tissue Is a Source of Multipotent Stem Cells." Molecular Biology of the Cell 13, no. 12 (2002): 4279–95. http://dx.doi.org/10.1091/mbc.e02-02-0105.

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Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, termed processed lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and, like MSCs, differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. To confirm whether adipo

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Szala, Stanisław, Ewa Wiśniewska, and Justyna Czapla. "Mesenchymal Stromal Cells." Postępy Higieny i Medycyny Doświadczalnej 68 (November 13, 2014): 1287–98. http://dx.doi.org/10.5604/17322693.1128671.

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Bernardo, Maria Ester, Franco Locatelli, and Willem E. Fibbe. "Mesenchymal Stromal Cells." Annals of the New York Academy of Sciences 1176, no. 1 (2009): 101–17. http://dx.doi.org/10.1111/j.1749-6632.2009.04607.x.

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Lalu, Manoj M., Lauralyn L. McIntyre, and Duncan J. Stewart. "Mesenchymal stromal cells." Critical Care Medicine 40, no. 4 (2012): 1373–75. http://dx.doi.org/10.1097/ccm.0b013e31824317f7.

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Keating, Armand. "Mesenchymal stromal cells." Current Opinion in Hematology 13, no. 6 (2006): 419–25. http://dx.doi.org/10.1097/01.moh.0000245697.54887.6f.

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Horwitz, Edwin M., Michael Andreef, and Francesco Frassoni. "Mesenchymal Stromal Cells." Biology of Blood and Marrow Transplantation 13 (January 2007): 53–57. http://dx.doi.org/10.1016/j.bbmt.2006.10.016.

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van Oers, Nicolai S., Qiumei Du, M. Teresa de la Morena, Igor Dozmorov, Shaheen Khan, and Ondine Cleaver. "Characterization of the Thymic Hypoplasia in Mouse Models of 22q11.2 Deletion Syndrome (DiGeorge Syndrome)." Journal of Immunology 200, no. 1_Supplement (2018): 166.19. http://dx.doi.org/10.4049/jimmunol.200.supp.166.19.

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Abstract Patients with 22q11.2 deletion syndrome have variable, multi-system disorders including a thymic hypoplasia, cardiac anomalies, and hypoparathyroidism. Over 90% have a deletion of 2.5 Mb on chromosome 22q11.2, affecting protein coding genes, microRNAs, long noncoding RNAs, and pseudogenes. 50%~70% have some degree of thymic hypoplasia (DiGeorge syndrome), resulting in a T cell lymphopenia. Successful transplantation of thymic tissue in patients with a thymic aplasia suggests stromal tissue abnormalities. The thymic stroma consists of thymic epithelial cells (TEC), mesenchymal cells, a

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Josson, Sajni, Starlette Sharp, Shian-Ying Sung, et al. "Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells." Journal of Oncology 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/232831.

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HS-27a human bone stromal cells, in 2D or 3D coultures, induced cellular plasticity in human prostate cancerARCaPEandARCaPMcells in an EMT model. CoculturedARCaPEorARCaPMcells with HS-27a, developed increased colony forming capacity and growth advantage, withARCaPEexhibiting the most significant increases in presence of bone or prostate stroma cells. Prostate (Pt-N or Pt-C) or bone (HS-27a) stromal cells induced significant resistance to radiation treatment inARCaPEcells compared toARCaPMcells. However pretreatment with anti-E-cadherin antibody (SHEP8-7) or anti-alpha v integrin blocking antib

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Ylikomi, T., and P. Tuohimaa. "Sex steroid sensitivity of developing bursa of Fabricius." International Journal of Developmental Biology 33, no. 1 (1989): 135–40. https://doi.org/10.1387/ijdb.2485693.

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Sex steroid sensitivity of the bursa of Fabricius (BF) was studied from the early embryonic time until its regression. Expression of progesterone receptor (PR) served as a dual marker: first, as a marker for progesterone sensitivity and second, as a marker for estrogen action, since it is an estrogen-induced protein. The progesterone binding molecule in the bursa was characterized by different chromatography methods and by steroid binding studies. We showed that it fulfils the criteria of a progesterone receptor by binding, structural and immunological properties. With immunohistochemistry and

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Saini, Francesca, Richard H. Argent, and Anna M. Grabowska. "Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma." Cells 8, no. 5 (2019): 424. http://dx.doi.org/10.3390/cells8050424.

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Pancreatic ductal adenocarcinoma (PDAC) is characterised by desmoplasia, thought to support progression and chemotherapeutic resistance. The Hedgehog pathway is known to play an important role in this cancer. While the upregulation of Sonic hedgehog (Shh) in the epithelium of PDAC is known, we investigated its expression in the tumour microenvironment in order to find new targets for new chemotherapeutical approaches. Immunohistochemistry was used for the investigation of Shh and Vimentin in primary human pancreatic tissues. Gene (qRT-PCR) and protein (immunofluorescence) expression of Shh, αS

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Tetteh, Doris Narki, Mari Hikosaka-Kuniishi, and Hidetoshi Yamazaki. "Neural crest-derived mesenchymal cells support thymic reconstitution after lethal irradiation." Journal of Immunology 210, no. 1_Supplement (2023): 219.18. http://dx.doi.org/10.4049/jimmunol.210.supp.219.18.

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Abstract The thymus is composed of thymocytes and stromal cells including thymic epithelial and mesenchymal cells. Thymic mesenchymal cells are originated from Neural Crest (NC) cells and the mesoderm. Although it is known that NC-derived (NCd) cells contribute to thymus organogenesis and thymus development, their specific role in T cell regeneration is unclear. To evaluate the regenerative ability of NCd mesenchymal cells in the thymus, we used lethally irradiated mice to examine the effect of ionizing irradiation (IR) on the thymus size, thymocytes and the thymic stromal cells (thymic epithe

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Busek, P., M. Zubal, B. Chmielova, et al. "P11.41 Comparison of fibroblast activation protein expression and localization in glioblastomas and brain metastases." Neuro-Oncology 21, Supplement_3 (2019): iii52. http://dx.doi.org/10.1093/neuonc/noz126.187.

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Abstract BACKGROUND Fibroblast activation protein (FAP) is a transmembrane serine protease that is frequently upregulated in the tumor microenvironment. In several cases, FAP protein itself and/or FAP expressing stromal cells have been shown to contribute to cancer progression and to be associated with more aggressive cancer behaviour and shorter patient survival. The aim of this study was to determine FAP expression in glioblastomas and brain metastases and to identify the cell types that express FAP in the microenvironment of these malignancies. MATERIAL AND METHODS FAP enzymatic activity an

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Kojima, Kensuke, Teresa McQueen, Elizabeth J. Shpall, Rui-Yu Wang, and Michael Andreeff. "p53 Activation of Mesenchymal Stromal Cells (MSC) Partially Abrogates Microenvironment-Mediated Resistance to FLT3 Inhibition In FLT3/ITD AML." Blood 116, no. 21 (2010): 2151. http://dx.doi.org/10.1182/blood.v116.21.2151.2151.

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Abstract Abstract 2151 Fms-like tyrosine kinase-3 (FLT3) inhibitors have recently been introduced to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3/ITD mutations. However, while ciculating blasts are rapidly eliminated, bone marrow (BM) responses are in general less impressive (Zhang et al., JCI 2009). One potential explanation for the reduced bone marrow response compared to the striking activity against circulating blast cells may be microenvironmental resistance to FLT3 inhibitors, including protection of FLT3/ITD+ blasts through the SDF-1 (CXCL12)/CXCR4 axis (Zeng

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Seidel, Tina, Nupur Ohri, Markus Glaß, Yoshiaki Sunami, Lutz P. Müller, and Jörg Kleeff. "Stromal Cells in Early Inflammation-Related Pancreatic Carcinogenesis—Biology and Its Potential Role in Therapeutic Targeting." Cancers 17, no. 9 (2025): 1541. https://doi.org/10.3390/cancers17091541.

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The stroma of healthy pancreases contains various non-hematopoietic, non-endothelial mesenchymal cells. It is altered by chronic inflammation which in turn is a major contributor to the development of pancreatic adenocarcinoma (PDAC). In PDAC, the stroma plays a decisive and well-investigated role for tumor progression and therapy response. This review addresses the central role of stromal cells in the early inflammation-driven development of PDAC. It focuses on major subpopulations of pancreatic mesenchymal cells, i.e., fibroblasts, pancreatic stellate cells, and multipotent stroma cells, par

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Jang, So-Dam, Jeeyeun Song, Hyun-Ah Kim, et al. "Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages." Cancers 13, no. 23 (2021): 5955. http://dx.doi.org/10.3390/cancers13235955.

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Activated pancreatic stellate cells (aPSCs) and M2 macrophages modulate tumor progression and therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC) via epithelial-mesenchymal transition (EMT). Here, our aim was to analyze the anti-invasion effects of anti-cancer agents where EMT-inducing cancer-stroma interaction occurs under three-dimensional (3D) culture conditions. We used microfluidic channel chips to co-culture pancreatic tumor spheroids (TSs) with aPSCs and THP-1-derived M2 macrophages (M2 THP-1 cells) embedded in type I collagen. Under stromal cell co-culture conditions, PANC-

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Balaziova, Eva, Petr Vymola, Petr Hrabal, et al. "Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis." Cancers 13, no. 13 (2021): 3304. http://dx.doi.org/10.3390/cancers13133304.

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Fibroblast activation protein (FAP) is a membrane-bound protease that is upregulated in a wide range of tumours and viewed as a marker of tumour-promoting stroma. Previously, we demonstrated increased FAP expression in glioblastomas and described its localisation in cancer and stromal cells. In this study, we show that FAP+ stromal cells are mostly localised in the vicinity of activated CD105+ endothelial cells and their quantity positively correlates with glioblastoma vascularisation. FAP+ mesenchymal cells derived from human glioblastomas are non-tumorigenic and mostly lack the cytogenetic a

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Masterson, Claire, James Devaney, Shahd Horie, et al. "Syndecan-2–positive, Bone Marrow–derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats." Anesthesiology 129, no. 3 (2018): 502–16. http://dx.doi.org/10.1097/aln.0000000000002327.

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Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background Human mesenchymal stromal cells demonstrate promise for acute respiratory distress syndrome, but current studies use highly heterogenous cell populations. We hypothesized that a syndecan 2 (CD362)–expressing human mesenchymal stromal cell subpopulation would attenuate Escherichia coli–induced lung injury and enhance resolution after ventilator-induced lung injury. Methods In vitro studies determined whether CD362+ human mesenchymal stromal cells could modulate pulmonary epithelial inflammation, wou

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Kollampally, Sujith Chander Reddy, Xulang Zhang, Nicholas Moskwa, et al. "Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance." Bioengineering 11, no. 4 (2024): 375. http://dx.doi.org/10.3390/bioengineering11040375.

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Mesenchymal stromal cells (MSCs) have displayed potential in regenerating organ function due to their anti-fibrotic, anti-inflammatory, and regenerative properties. However, there is a need for delivery systems to enhance MSC retention while maintaining their anti-fibrotic characteristics. This study investigates the feasibility of using alginate hydrogel microstrands as a cell delivery vehicle to maintain MSC viability and phenotype. To accommodate cell implantation needs, we invented a Syringe-in-Syringe approach to reproducibly fabricate microstrands in small numbers with a diameter of arou

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Jerkic, Mirjana, Stéphane Gagnon, Razieh Rabani, et al. "Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats." Anesthesiology 132, no. 1 (2020): 140–54. http://dx.doi.org/10.1097/aln.0000000000003018.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Mesenchymal stromal cells have therapeutic potential in sepsis, but the mechanism of action is unclear. We tested the effects, dose-response, and mechanisms of action of cryopreserved, xenogeneic-free human umbilical cord mesenchymal stromal cells in a rat model of fecal peritonitis, and examined the role of heme oxygenase-1 in protection. Methods Separate in vivo experiments evaluated mesenchymal stromal cells in fecal sepsis, established dose response (2, 5, and 10 million ce

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Jacamo, Rodrigo, Ye Chen, Zhiqiang Wang та ін. "NF-κB Activation in Mesenchymal Stromal Cells Mediates Leukemia Cell Chemoresistance". Blood 120, № 21 (2012): 3518. http://dx.doi.org/10.1182/blood.v120.21.3518.3518.

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Abstract Abstract 3518 Within the bone marrow (BM) microenvironment, BM mesenchymal stromal cells (BM-MSC) provide leukemia cells with a rich environment that serves as a sanctuary and protects them from chemotherapeutic agents. Interactions between leukemia cells and BM-MSC are thought to change the behavior of both stroma and leukemia cells resulting in an increased resistance to standard drugs. To discover interaction-induced changes in BM-MSCs that might promote microenvironment-mediated chemoresistance we used genome-wide gene expression profiling to study normal-donor BM-MSCs co-cultured

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Kojima, Kensuke, Teresa McQueen, Ye Chen та ін. "p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α–mediated down-regulation of CXCL12". Blood 118, № 16 (2011): 4431–39. http://dx.doi.org/10.1182/blood-2011-02-334136.

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Abstract Fms-like tyrosine kinase-3 (FLT3) inhibitors have been used to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3 mutations. Clinical results with FLT3 inhibitor monotherapy have shown that bone marrow responses are commonly less pronounced than peripheral blood responses. We investigated the role of p53 in bone marrow stromal cells in stromal cell-mediated resistance to FLT3 inhibition in FLT3 mutant AML. While the FLT3 inhibitor FI-700 induced apoptosis in FLT3 mutant AML cells, apoptosis induction was diminished under stromal coculture conditions. Protection ap

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Nauta, Alma J., and Willem E. Fibbe. "Immunomodulatory properties of mesenchymal stromal cells." Blood 110, no. 10 (2007): 3499–506. http://dx.doi.org/10.1182/blood-2007-02-069716.

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Abstract Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple lineages of the mesenchyme. MSCs have emerged as a promising therapeutic modality for tissue regeneration and repair. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more importantly, display immunomodulatory capacities. Although the mechanisms underlying the immunosuppressive effects of MSCs have not been clearly defined, their immunosuppressive properties have already been exploited in the clinical setting. The a

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Nizyaeva, N. V., Т. V. Sukhacheva, G. V. Kulikova, et al. "Morphological Features of Mesenhymal Stroma Cells of Chorionic Villi." Annals of the Russian academy of medical sciences 72, no. 1 (2017): 76–83. http://dx.doi.org/10.15690/vramn767.

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Background: Nowadays autologous mesenchymal placental stromal cells (MSCs) may use to treat for various diseases both of the mother and the child. Stroma of the placenta villi is appropriated origin for cell culture isolation. Aim of the study was to evaluate the possibility for selection and use of placental tissue for mesenchymal stromal cells. Materials and methods: The present study was based on 45 placental samples of women aged 27−38 yy. who underwent surgical delivery at 36−40 weeks of gestation. 30 of these women have been enrolled in the basic group including children with congenital

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Lee, Rebecca, Nicoletta Del Papa, Martin Introna, et al. "Adipose-derived mesenchymal stromal/stem cells in systemic sclerosis: Alterations in function and beneficial effect on lung fibrosis are regulated by caveolin-1." Journal of Scleroderma and Related Disorders 4, no. 2 (2019): 127–36. http://dx.doi.org/10.1177/2397198318821510.

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The potential value of mesenchymal stromal/stem cell therapy in treating skin fibrosis in scleroderma (systemic sclerosis) and of the caveolin-1 scaffolding domain peptide in treating lung, skin, and heart fibrosis is known. To understand how these observations may relate to differences between mesenchymal stromal/stem cells from healthy subjects and subjects with fibrosis, we have characterized the fibrogenic and adipogenic potential of adipose-derived mesenchymal stromal/stem cells from systemic sclerosis patients, from mice with fibrotic lung and skin disease induced by systemic bleomycin t

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Lim, Hong Kiat, Pravin Periasamy, and Helen C. O’Neill. "In Vitro Murine Hematopoiesis Supported by Signaling from a Splenic Stromal Cell Line." Stem Cells International 2018 (December 25, 2018): 1–9. http://dx.doi.org/10.1155/2018/9896142.

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There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the differentiation of hematopoietic cells from progenitors in vitro. Initially, 5G3 was shown to express markers of mesenchymal but not endothelial or hematopoietic cells and to resemble perivascular reticular cells in the bone marrow through gene expression. In particular, 5G3 resembl

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Zhu, H. B., D. Z. Guo, S. J. Yang, et al. "Osteogenic actions of the osteogenic growth peptide on bovine marrow mesenchymal stromal cells in culture." Veterinární Medicína 53, No. 9 (2008): 501–9. http://dx.doi.org/10.17221/1981-vetmed.

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The osteogenic growth peptide (OGP) regulates the differentiation of marrow mesenchymal stem cells derived from human and rodent cell lines into osteoblasts. Whether OGP directly regulates the bovine marrow mesenchymal stem cells differentiating into osteoblasts remains unknown. In this study, we evaluated the effects of OGP on the growth and differentiation of bovine marrow mesenchymal stem cells in culture. Our results showed that OGP promoted osteogenic differentiation of the bovine stem cells. OGP increased alkaline phosphatase (ALP) activity and mineralized nodule formation, and stimulate

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Liu, Dajia, Anne Steins, Remy Klaassen, et al. "Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma." Biomedicines 8, no. 11 (2020): 444. http://dx.doi.org/10.3390/biomedicines8110444.

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Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed to explore how hypoxia and stroma interact to contribute to invasive growth in PDAC. [18F]HX4 PET/CT was found to be a feasible non-invasive method to assess tumor hypoxia in 42 patients and correlated with HIF1α immunohistochemistry in matched surgical specimens. [18F]HX4 uptake and HIF1α were strong prognostic markers for overall survi

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