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Dissertations / Theses on the topic 'Messenger RNA-binding proteins'

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Published: 25 January 2025

Last updated: 31 July 2025

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1

Kylberg, Karin. "Transcription and transport of a messenger RNP particle : novel regulatory mechanisms /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-318-4/.

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2

Nashchekin, Dmitri. "A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-811-8/.

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3

Zhong, Jun. "A double-stranded RNA binding protein that is important for murine spermatogenesis and growth /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10301.

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4

Fred, Rikard G. "The Role of RNA Binding Proteins in Insulin Messenger Stability and Translation." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130234.

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Although the reason for insufficient release of insulin in diabetes mellitus may vary depending on the type and stage of the disease, it is of vital importance that an amplified insulin biosynthesis can meet the increased need during periods of hyperglycemia. The insulin mRNA is highly abundant in beta cells and changes in insulin mRNA levels are, at least in part, controlled by altered rates of mRNA degradation. Since the mechanisms behind the control of insulin messenger stability and translation are still largely obscure, the work presented in this thesis therefore aimed to further investig

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5

Park, Youngwoo. "Selective translation of influenza viral messenger RNAs mediated by trans-acting factor(s) through an interaction with the sequence element in the 5'-untranslated region /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11496.

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6

Zhang, Tong. "Characterization of the shuttling properties of RNA-binding TIA proteins." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210999.

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7

Maitra, Sushmit. "The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase activated protein kinase 2." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/maitra.pdf.

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8

Katti, Christiana. "Characterization of the S-adenosyl-L-methionine binding subunit of the mRNA (N⁶-adenosine) methyltransferase /." View abstract, 2005. http://wwwlib.umi.com/dissertations/fullcit/3205449.

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9

Kaymak, Ebru. "Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/852.

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Maternally supplied mRNAs encode for necessary developmental regulators that pattern early embryos in many species until zygotic transcription is activated. In Caenorhabditis elegans, post-transcriptional regulatory mechanisms guide early development during embryogenesis. Maternal transcripts remain in a translationally silenced state until fertilization. A suite of RNA-binding proteins (RBP’s) regulate these maternally supplied mRNAs during oogenesis, the oocyte-to-embryo transition, and early embryogenesis. Identifying the target specificity of these RNA-binding proteins will reveal their co

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10

Kaymak, Ebru. "Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/852.

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Maternally supplied mRNAs encode for necessary developmental regulators that pattern early embryos in many species until zygotic transcription is activated. In Caenorhabditis elegans, post-transcriptional regulatory mechanisms guide early development during embryogenesis. Maternal transcripts remain in a translationally silenced state until fertilization. A suite of RNA-binding proteins (RBP’s) regulate these maternally supplied mRNAs during oogenesis, the oocyte-to-embryo transition, and early embryogenesis. Identifying the target specificity of these RNA-binding proteins will reveal their co

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11

Deveau, Laura M. "Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/855.

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RNA-binding proteins (RBPs) are important for a wide variety of biological processes involved in gene regulation. However, the structural and dynamic contributions to their biological activity are poorly understood. The tristetraprolin (TTP) family of RBPs, including TTP, TIS11b and TIS11d, regulate the stability of mRNA transcripts encoding for key cancer-related proteins, such as tumor necrosis factor- and vascular endothelial growth factor. Biophysical studies have shown that the RNA binding domain, consisting of two CCCH zinc fingers (ZFs), is folded in the absence of RNA in TIS11d and TI

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12

Alibhai, Imran Nizamudin. "Regulation of FOSB MRNA isoforms by drugs of abuse." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=144.

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13

Sánchez-Velar, Nuria. "The Human Rev Interacting Protein (hRIP) is Required for Rev Function and HIV-1 Replication: a Dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/312.

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Retroviruses have evolved sophisticated mechanisms to ensure timely export of incompletely spliced viral messenger ribonucleic acids (mRNAs) for gene expression and for viral packaging. For example, the Human Immunodeficiency Virus type 1 (HIV-1) encodes the Rev regulatory protein, a sequence-specific RNA-binding protein that is responsible for the cytoplasmic accumulation of intron-containing viral mRNAs. The HIV-1 Rev protein contains an amino terminal (N-terminal) Arginine-Rich Motif (ARM) RNA-binding domain (RBD) and a carboxy terminal (C-terminal) leucine-rich activation domain which func

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14

Lavrynenko, Kyrylo. "The interaction of Caprin1 and G3BP1, major proteins in stress granule assembly, promotes the messenger RNA recruitment by G3BP1." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL133.

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Les protéines de liaison à l'ARN (RBP) jouent un rôle majeur dans la régulation de la traduction de l'ARN messager et l'adaptation du métabolisme cellulaire à divers signaux environnementaux. La présence dans de nombreuses RBP d'une combinaison unique de domaines fonctionnels structurés et de régions intrinsèquement désordonnées, leur permet de générer des condensats riches en ARN par le processus de séparation de phase liquide-liquide. G3BP1 est une RBP centrale dans le processus de protection de l'ARNm lorsque les cellules sont exposées à des stress environnementaux via la formation des gran

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15

Kan, Ming-Chung. "Analysis of CPEB Family Protein Member CPEB4 Function in Mammalian Neurons: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/362.

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Local protein synthesis is required for long-term memory formation in the brain. One protein family, Cytoplasmic Polyadenylation Element binding Protein (CPEB) that regulates protein synthesis is found to be important for long-term memory formation possibly through regulating local protein synthesis in neurons. The well-studied member of this family, CPEB1, mediates both translational repression and activation of its target mRNAs by regulating mRNA polyadenylation. Mouse with CPEB1 KO shows defect in memory extinction but not long-term memory formation. Three more CPEB1 homologs (CPEB2-4) are

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16

Braz, Sandra Catarina Oliveira. "Alternative polyadenylation of Rho GTPases : a gene/cell specific process." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14865.

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Mestrado em Biologia Molecular e Celular<br>Alternative polyadenylation (APA) is an important mechanism of gene regulation that occurs in 70% of eukaryotic organisms. This process comprises the formation of alternative 3’ ends of an mRNA by cleavage of the pre-mRNA and polyadenylation at different sites according to the polyadenylation signals (pAs). The choice of pAs in APA is a co-transcriptional mechanism that depends on auxiliary cis- and trans-acting factors. The usage of the proximal or the distal pAs has been related to global physiologic events. It is consensually assumed that in

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17

Loushin, Newman Carrie Lee. "Characterization of QKI RNA binding function /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004323.

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18

Livi, Carmen Maria. "Protein-dependent prediction of messenger RNA binding using Support Vector Machines." Doctoral thesis, Università degli studi di Trento, 2013. https://hdl.handle.net/11572/369261.

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RNA-binding proteins interact specifically with RNA strands to regulate important cellular processes. Knowing the binding partners of a protein is a crucial issue in biology and it is essential to understand the protein function and its involvement in diseases. The identification of the interactions is currently resolvable only through in vivo and in vitro experiments which may not detect all binding partners. Computational methods which capture the protein-dependent nature of the binding phenomena could help to predict, in silico, the binding and could be resistant against experimental biases

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19

Livi, Carmen Maria. "Protein-dependent prediction of messenger RNA binding using Support Vector Machines." Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/995/1/phd-thesisLivi.pdf.

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RNA-binding proteins interact specifically with RNA strands to regulate important cellular processes. Knowing the binding partners of a protein is a crucial issue in biology and it is essential to understand the protein function and its involvement in diseases. The identification of the interactions is currently resolvable only through in vivo and in vitro experiments which may not detect all binding partners. Computational methods which capture the protein-dependent nature of the binding phenomena could help to predict, in silico, the binding and could be resistant against experimental biases

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20

Wang, Weizhong. "Nuclear galectins and their role in pre-mRNA splicing." Diss., Connect to online resource - MSU authorized users, 2006.

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Thesis (Ph. D.)--Michigan State University. Dept. of Microbiology and Molecular Genetics, 2006.<br>Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references. Also issued in print.

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21

O'Leary, Debra Alison. "Characterisation of gene structure and function of the ETS transcription factor Gabpα in mouse". Monash University, Centre for Functional Genomics and Human Disease, 2003. http://arrow.monash.edu.au/hdl/1959.1/9445.

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22

Tatsumi, Keiji. "Expression of calcium binding protein D-9k messenger RNA in the mouse uterine endometrium during implantation." Kyoto University, 1999. http://hdl.handle.net/2433/181740.

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23

Badilla, Lobo Adriana. "Characterization of a family of small proteins regulated by second messenger-binding riboswitches in Clostridioides difficile." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL120.

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Clostridioides difficile est une cause majeure de diarrhée nosocomiale. La physiopathologie de C. difficile est régie par des réseaux de régulation complexes, incluant des mécanismes basés sur l'ARN tels que les riboswitches. Les riboswitches, situés dans la région 5' non traduite des ARNm, se lient à des ligands spécifiques, induisant des changements de conformation qui modulent l'expression du gène en aval. Chez C. difficile, 16 riboswitches répondent à la molécule de signalisation c-di-GMP. Le c-di-GMP est un régulateur contrôlant la transition d'un mode de vie planctonique libre à un mode

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24

Andric, Vedrana. "Study of the mechanisms of sexual differentiation in the fission yeast Schizosaccharomyces pombe Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression A scaffold lncRNA shapes the mitosis to meiosis switch." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL056.

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Chez la levure fissipare Schizosaccharomyces pombe, un sous-ensemble de gènes méiotiques est transcrit de manière constitutive au cours de la mitose. Afin d’éviter l'expression prématurée du programme méiotique et l'initiation de la différenciation sexuelle, les cellules ont développé un système de dégradation de l'ARN qui élimine sélectivement les transcrits méiotiques correspondants. Ce processus nécessite la protéine de liaison à l'ARN Mmi1 (à domaine YTH), qui reconnaît en cis les molécules d'ARN (motifs UNAAAC) et les cible pour la dégradation par l'exosome nucléaire. Au début de la méios

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25

Nilsson, Mikael. "Protein-DNA recognition : in vitro evolution and characterization of DNA-binding proteins /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4269.

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26

Brown, Kelly Rae. "Effects of l-carnitine on gilt growth, fetal growth and fetal muscle characteri[s]tics, and the IFG system in pigs harvested at day 40, 55, and 70 of gestation." Diss., Manhattan, Kan. : Kansas State University, 2006. http://hdl.handle.net/2097/162.

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27

MARTINS, DE SA CESAR. "Contribution a l'etude de facteurs cytoplasmiques intervenant dans la regulation post-transcriptionnelle de l'expression genetique chez les eucaryotes." Paris 7, 1988. http://www.theses.fr/1988PA077114.

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28

Perret, Christine. "Gene de la cabp 9k de rat : expression et structure." Paris 6, 1988. http://www.theses.fr/1988PA066472.

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29

Grossi, de Sa Maria-Fatima. "Etudes des facteurs associes aux rna messagers : aspects biochimiques et immuno-cytochimiques des prosomes pendant la differenciation et le developpement, l'implication de la proteine poly(a) dans la synthese proteique." Paris 7, 1987. http://www.theses.fr/1987PA077116.

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L'etude des facteurs intervenant dans la regulation post-transcriptionnelle de l'expression genique a permis de caracteriser les prosomes (classe de particules ribonucleoproteiques (rnp)) qui s'associent aux complexes mrnp reprimes et d'etudier le role de la proteine poly(a) associee aux rnam traduits dans les polyribosomes. Le prosome est un complexe rnp, de coefficient sedimentation 19s, constitues de petits rna (prna) et de proteines presentant une structure hautement organisee. La caracterisation biochimique et immunologique des prosomes de plusieurs cellules montrent que certaines protein

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30

"Determination of phosphorylation sites of Drosophila melanogaster exuperantia protein by site-directed mutagenesis." 1999. http://library.cuhk.edu.hk/record=b5896323.

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Chan Kam Leung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (leaves 175-182).<br>Abstract also in Chinese.<br>Acknowledgements --- p.i<br>Abstract --- p.ii<br>Abbreviations --- p.v<br>Table of Contents --- p.vii<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1 --- Drosophila as a model for studying development --- p.1<br>Chapter 1.2 --- The formation of the body axis in Drosophila --- p.2<br>Chapter 1.3 --- The maternal genes are essential for development --- p.9<br>Chapter 1.4 --- Maternal gene bicoid is essential for f

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31

Chaturvedi, Praneet. "Role of post-transcriptional regulation in human liver." Thesis, 2015. http://hdl.handle.net/1805/6625.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>My thesis comprises of two individual projects which revolve around the importance of post-transcriptional regulation in liver. My first project is studying the integrated miRNA – mRNA network in NAFLD. For fulfillment of the study we conducted a genome-wide study to identify microRNAs (miRs) as well as the miR-mRNA regulatory network associated with hepatic fat and NAFLD. Hepatic fat content (HFC), miR and mRNA expression were assessed in 73 human liver samples. Liver histology of 49 samples was further characterized into normal (n=

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32

Ramesh, V. "Studies On Polypyrimidine Tract Binding Protein : Identification Of Interacting Partners." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/659.

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PTB (HnRNP I) is a multifunctional RNA binding protein which participates in a variety of RNA metabolic processes put together called as post transcriptional gene regulation. It interacts with shuttling hnRNPs L, K and E2 of the spliceosomal machinery and also with other RNA binding proteins like PSF, Raver1 and Raver2, which assists PTB in splicing. Based on the complexity of these processes and multifunctional nature of PTB, we hypothesized that; it might interact with various additional proteins not identified till date. Keeping this objective in mind, we set out to screen the custom made 1

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33

Ramesh, V. "Studies On Polypyrimidine Tract Binding Protein : Identification Of Interacting Partners." Thesis, 2009. http://hdl.handle.net/2005/659.

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PTB (HnRNP I) is a multifunctional RNA binding protein which participates in a variety of RNA metabolic processes put together called as post transcriptional gene regulation. It interacts with shuttling hnRNPs L, K and E2 of the spliceosomal machinery and also with other RNA binding proteins like PSF, Raver1 and Raver2, which assists PTB in splicing. Based on the complexity of these processes and multifunctional nature of PTB, we hypothesized that; it might interact with various additional proteins not identified till date. Keeping this objective in mind, we set out to screen the custom made 1

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34

Jackson, B. R., James R. Boyne, M. Noerenberg, et al. "An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export." 2011. http://hdl.handle.net/10454/6028.

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The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, deplet

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35

Boyne, J. R., K. J. Colgan, and A. Whitehouse. "Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication." 2008. http://hdl.handle.net/10454/5869.

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A cellular pre-mRNA undergoes various post-transcriptional processing events, including capping, splicing and polyadenylation prior to nuclear export. Splicing is particularly important for mRNA nuclear export as two distinct multi-protein complexes, known as human TREX (hTREX) and the exon-junction complex (EJC), are recruited to the mRNA in a splicing-dependent manner. In contrast, a number of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic mRNAs lack introns and are exported by the virus-encoded ORF57 protein. Herein we show that ORF57 binds to intronless viral mRNAs and functions to r

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36

Dhar, Debojyoti. "Regulation Of Interferon Regulatory Factor-2 mRNA Translation By 'IRES' Element : Possible Role Of trans Acting Factors." Thesis, 2007. http://etd.iisc.ac.in/handle/2005/607.

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Cellular response to various stress conditions involves regulation of gene expression by different mechanisms. Translation is the final step in the flow of genetic information and regulation at this level allows an early response to changes in physiological conditions. Initiation of translation is the rate-limiting step of protein synthesis and hence is tightly regulated. Translation initiation in mammalian cells is mainly by “cap dependent pathway” wherein the 5’methyl guanosine “cap” structure is recognized by certain canonical initiation factors along with 40S ribosomal subunit and the comp

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37

Dhar, Debojyoti. "Regulation Of Interferon Regulatory Factor-2 mRNA Translation By 'IRES' Element : Possible Role Of trans Acting Factors." Thesis, 2007. http://hdl.handle.net/2005/607.

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Cellular response to various stress conditions involves regulation of gene expression by different mechanisms. Translation is the final step in the flow of genetic information and regulation at this level allows an early response to changes in physiological conditions. Initiation of translation is the rate-limiting step of protein synthesis and hence is tightly regulated. Translation initiation in mammalian cells is mainly by “cap dependent pathway” wherein the 5’methyl guanosine “cap” structure is recognized by certain canonical initiation factors along with 40S ribosomal subunit and the comp

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38

Benoit, Bouvrette Louis Philip. "Caractérisation systématique des motifs de régulation en cis à l’échelle transcriptomique et liens avec la localisation des ARN." Thesis, 2020. http://hdl.handle.net/1866/24578.

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La localisation subcellulaire de l’ARN permet un déploiement prompt et spatialement restreint autant des activités protéiques que des ARN noncodant. Le trafic d’ARN est dirigé par des éléments de séquences (sous-séquences primaires, structures secondaires), aussi appelés motifs de régulation, présents en cis à même la molécule d’ARN. Ces motifs sont reconnus par des protéines de liaisons aux ARN qui médient l’acheminement des transcrits vers des sites précis dans la cellule. Des études récentes, chez l’embryon de Drosophile, indiquent que la majorité des ARN ont une localisation subcellulaire

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39

Condé, Lionel. "Implication de la protéine Staufen 2 dans les voies de réponse aux dommages à l’ADN." Thesis, 2020. http://hdl.handle.net/1866/24468.

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De nombreuses voies de signalisation cellulaire complexes permettent de répondre à la présence de dommages à l’ADN. Cette réponse cellulaire est indispensable afin d’éviter l’accumulation de mutations pouvant éventuellement conduire à la transformation tumorale. Ces différentes voies de réponse aux dommages à l’ADN sont hautement coordonnées et sont regroupées au sein d’un mécanisme global appelé DNA damage response (DDR). Les facteurs du DDR sont régulés à plusieurs niveaux de la cascade de l’expression des gènes. De façon notable, plusieurs protéines de liaison à l’ARN (RBP) participent à la

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