Academic literature on the topic 'Metallo-B-lactamase genes'

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Journal articles on the topic "Metallo-B-lactamase genes"

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Garau, Gianpiero, Anne Marie Di Guilmi та Barry G. Hall. "Structure-Based Phylogeny of the Metallo-β-Lactamases". Antimicrobial Agents and Chemotherapy 49, № 7 (2005): 2778–84. http://dx.doi.org/10.1128/aac.49.7.2778-2784.2005.

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ABSTRACTThe metallo-β-lactamases fall into two groups: Ambler class B subgroups B1 and B2 and Ambler class B subgroup B3. The two groups are so distantly related that there is no detectable sequence homology between members of the two different groups, but homology is clearly detectable at the protein structure level. The multiple structure alignment program MAPS has been used to align the structures of eight metallo-β-lactamases and five structurally homologous proteins from the metallo-β-lactamase superfamily, and that alignment has been used to construct a phylogenetic tree of the metallo-β
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Matsumoto, Takehisa, Mika Nagata, Nau Ishimine та ін. "Characterization of CIA-1, an Ambler Class A Extended-Spectrum β-Lactamase from Chryseobacterium indologenes". Antimicrobial Agents and Chemotherapy 56, № 1 (2011): 588–90. http://dx.doi.org/10.1128/aac.05165-11.

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ABSTRACTAn Ambler class A β-lactamase gene,blaCIA-1, was cloned from the reference strainChryseobacterium indologenesATCC 29897 and expressed inEscherichia coliBL21. TheblaCIA-1gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively.blaCIA-1-like genes were detected from clinical isolates. In addition to the metallo-β-lactamase IND of Ambler class B,C. indologeneshas a class A ESBL gene,blaCIA-1, located on the chromosome.
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Abbas Aboud, Ali. "Molecular Investigation of Metallo B-Lactamase genes in Klebsiella Pneumoniae Bacteria from Clinical Isolates." Osol Journal for Medical Sciences 2, no. 2 (2024): 19–28. https://doi.org/10.69946/ojms/2024.02.02.03.

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Klebsiella pneumoniae is a significant nosocomial bacteria, that causes a large range of infections e.g. bacteremia, pneumonia, meningitis, and urinary tract infections. The current study intends to detect the existence of specific genes (blaNDM-1, blaNDM-2, blaVIM, blaIMP) associated with metallo-beta-lactamase (MBL) production in multidrug-resistant Klebsiella pneumoniae isolates attained from various clinical isolate. These genes are responsible for conferring resistance to a wide range of antibiotics, making an infection caused by such bacteria difficult to treat. Two hundred and seventy e
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Biedenbach, Douglas J., Krystyna Kazmierczak, Samuel K. Bouchillon, Daniel F. Sahm, and Patricia A. Bradford. "In VitroActivity of Aztreonam-Avibactam against a Global Collection of Gram-Negative Pathogens from 2012 and 2013." Antimicrobial Agents and Chemotherapy 59, no. 7 (2015): 4239–48. http://dx.doi.org/10.1128/aac.00206-15.

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ABSTRACTThe combination of aztreonam plus avibactam is being developed for use in infections caused by metallo-β-lactamase-producingEnterobacteriaceaestrains that also produce serine β-lactamases. Thein vitroactivities of aztreonam-avibactam and comparator antimicrobials were determined against year 2012 and 2013 clinical isolates ofEnterobacteriaceae,Pseudomonas aeruginosa, andAcinetobacter baumanniiusing the broth microdilution methodology recommended by the Clinical and Laboratory Standards Institute (CLSI). A total of 28,501 unique clinical isolates were obtained from patients in 190 medic
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Abaza, Amani F., Soraya A. El Shazly, Heba S. A. Selim, and Gehan S. A. Aly. "Metallo-Beta-Lactamase Producing Pseudomonas aeruginosa in a Healthcare Setting in Alexandria, Egypt." Polish Journal of Microbiology 66, no. 3 (2017): 297–308. http://dx.doi.org/10.5604/01.3001.0010.4855.

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Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students’ Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility pat
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Abdullah Mohamed, Maha Assayed, and Mohamed H. Arbab. "Prevalence of Multi Drug Resistant Pseudomonas Species Encoding SPM Metalo Beta Lactamase Gene Collected from Patients with Infected Wound in Khartoum State." SVOA Microbiology 5, no. 4 (2024): 143–47. http://dx.doi.org/10.58624/svoamb.2024.05.052.

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Background: Selection of the most appropriate antibiotic is complicated by the ability of P. aeruginosa to develop resistance to multiple classes of antibacterial agents, even during the course of treating an infection. As in all genes encoding bacteria, metalloB-Lactamases-producing strains (generally multidrug resistant) cause infections that are difficult to treat and resulting in a high mortality and morbidity rates in the community, an increase in both to extend and diversity of metallo-β- lactamases in Pseudomonas aeruginosa severely limits treatment and delay the process of healing the
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Bagheri Josheghani, Sareh, Rezvan Moniri, Farzaneh Firoozeh, Mojtaba Sehat, and Yasaman Dasteh Goli. "Susceptibility Pattern and Distribution of Oxacillinases andblaPER-1Genes among Multidrug ResistantAcinetobacter baumanniiin a Teaching Hospital in Iran." Journal of Pathogens 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/957259.

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Acinetobacter baumannii (A. baumannii)is an important nosocomial pathogen in healthcare institutions.β-Lactamase-mediated resistance is the most common mechanism for carbapenem resistance inA. baumannii. The aim of this study was to determine the antibiotic resistance pattern, to detectOXAencoding genes, class A,blaPER-1, and to detect the presence of ISAba1. A total of 124A. baumanniiisolates were collected from hospitalized patients in a teaching hospital in Kashan, Iran. The susceptibility of isolates to different antibiotics was determined by disk-diffusion method. PCR was used to detectbl
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Vivan, Ana Carolina Polano, Juliana Ferraz Rosa, Camila Fonseca Rizek, et al. "Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates from a university hospital in Brazil." Journal of Infection in Developing Countries 11, no. 05 (2017): 379–86. http://dx.doi.org/10.3855/jidc.8614.

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Introduction: The emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kpn) isolates is attracting significant attention in nosocomial infection settings. K. pneumoniae is the main pathogen that harbours blaKPC genes.
 Methodology: This study evaluated 54 K. pneumoniae carbapenem-resistant isolates from patients hospitalized at the University Hospital of Londrina, between July 2009 and July 2010. The isolates were phenotypically screened for carbapenemase production and submitted for genotypic confirmation by polymerase chain reaction (PCR) for KPC, metallo-
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Woodford, Neil, Marie-France I. Palepou, Gioia S. Babini, Barry Holmes та David M. Livermore. "Carbapenemases of Chryseobacterium(Flavobacterium) meningosepticum: Distribution ofblaB and Characterization of a Novel Metallo-β-Lactamase Gene, blaB3, in the Type Strain, NCTC 10016". Antimicrobial Agents and Chemotherapy 44, № 6 (2000): 1448–52. http://dx.doi.org/10.1128/aac.44.6.1448-1452.2000.

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ABSTRACT Genes encoding carbapenemases in 15 reference strains ofChryseobacterium (Flavobacterium)meningosepticum from the United Kingdom National Collection of Type Cultures and in one recent clinical isolate were investigated. All the strains hydrolyzed imipenem, but their levels of resistance to carbapenems varied, with imipenem and meropenem MICs ranging from 2 to >32 μg/ml. The blaB gene, which encodes a molecular-class B carbapenemase, was detected in only six reference strains and in clinical isolate 97/P/5448. The gene from 97/P/5448 had 98% nucleotide identity with the published se
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Lee, Kyungwon, Jong Back Lim, Jong Hwa Yum та ін. "bla VIM-2 Cassette-Containing Novel Integrons in Metallo-β-Lactamase-Producing Pseudomonas aeruginosa and Pseudomonas putida Isolates Disseminated in a Korean Hospital". Antimicrobial Agents and Chemotherapy 46, № 4 (2002): 1053–58. http://dx.doi.org/10.1128/aac.46.4.1053-1058.2002.

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ABSTRACT We investigated the phenotypic and genetic properties of metallo-β-lactamase-producing Pseudomonas isolates collected at a tertiary-care hospital in Korea since 1995. The prevalence of imipenem resistance among Pseudomonas aeruginosa isolates reached 16% in 1997, when 9% of the resistant organisms were found to produce VIM-2 β-lactamase, a class B enzyme previously found only in P. aeruginosa isolates from Europe. VIM-2-producing isolates of Pseudomonas putida were also detected. Resistance was transferable from both these species to P. aeruginosa PAO4089Rp by filter mating, although
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Dissertations / Theses on the topic "Metallo-B-lactamase genes"

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Ranjan, Vivek Kumar. "Search for molecular diversity of metallo-B-lactamase genes in eubacterial isolates of Karala and Mahananda rivers of West Bengal." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4663.

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