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Journal articles on the topic 'Methamphetamine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kenney, MD, Connor, Julie Rizzo, Elsa Coates, et al. "701 Impact of Alcohol and Methamphetamine Use on Burn Resuscitation." Journal of Burn Care & Research 44, Supplement_2 (2023): S126—S127. http://dx.doi.org/10.1093/jbcr/irad045.176.

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Abstract Introduction Mortality associated with burn injuries is declining with improved critical care, including resuscitation. However, patients admitted with concurrent substance use have increased risk of complications and poor outcomes. The impact of alcohol and methamphetamine use on acute burn resuscitation has been described in single center studies, however, has not been studied since implementation of computerized decision support for resuscitation. The purpose of this study was to evaluate resuscitation volumes for patients with alcohol and methamphetamine use within a large prospec

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Faucett, Erynne A., Katherine M. Marsh, Kayven Farshad, Audrey B. Erman, and Alexander G. Chiu. "Maxillary Sinus Manifestations of Methamphetamine Abuse." Allergy & Rhinology 6, no. 1 (2015): ar.2015.6.0106. http://dx.doi.org/10.2500/ar.2015.6.0106.

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Methamphetamines are the second most commonly used illicit drug worldwide and cost the United States health-care system ~$23.4 billion annually. Use of this drug affects multiple organ systems and causes a variety of clinical manifestations. Although there are commonly known sequelae of methamphetamine abuse such as “meth mouth,” there is limited evidence regarding maxillary sinus manifestations. The following cases highlight the initial evaluation and management of two methamphetamine abusers with loculated purulent collections within the maxillary sinus as a result of methamphetamine abuse.

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Hendrix, Joshua A., and Cindy Brooks Dollar. "American Slaughterhouses and the Need for Speed: An Examination of the Meatpacking-Methamphetamine Hypothesis." Organization & Environment 31, no. 2 (2017): 133–51. http://dx.doi.org/10.1177/1086026617697038.

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In Fast Food Nation, Eric Schlosser argues that slaughterhouse workers use methamphetamines to manage the harsh physical and emotional demands of the meatpacking industry. Similar ideas have been raised elsewhere; however, empirical tests of this hypothesis are in short supply. In this article, we elaborate on theoretical mechanisms that may explain why the meatpacking industry encourages methamphetamine use and provide a macro-level test of the meatpacking–methamphetamine hypothesis using 11 years (2001-2012) of hospital admission data and information from annual livestock slaughter reports.

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I, Younes, Elkattawy S, Noori M, and Posimreddy S. "Methamphetamine Induced Cardiomyopathy." Journal of Health Care and Research 1, no. 2 (2020): 78–82. http://dx.doi.org/10.36502/2020/hcr.6165.

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Unfortunately, 35 million people worldwide suffer from drug use disorder while only one in seven people receive treatment. The health impacts combined with the socioeconomic burden of drug abuse are too numerous to count. It is well known that all organ systems are adversely affected by drug use including but not limited to the cardiovascular, respiratory, neurological, and renal. We will focus our attention on the effects of Methamphetamines on the cardiovascular system. Methamphetamines are known to be highly addictive stimulants with significant cardiovascular implications. We have gathered

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Agustin, Michael, Gabriel David, Ji Yeong Kang, and Ornusa Teerasukjinda. "Spontaneous Pneumomediastinum and Diffuse Subcutaneous Emphysema after Methamphetamine Inhalation." Case Reports in Pulmonology 2020 (March 7, 2020): 1–3. http://dx.doi.org/10.1155/2020/7538748.

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Methamphetamines are commonly abused drugs for their stimulant and euphoric effects. Inhaled and intravenous use may cause damage to the respiratory system. Spontaneous pneumomediastinum is a condition where changes in intrathoracic pressure leads to alveolar rupture and dissection of air along the tracheobronchial tree. Massive subcutaneous emphysema may result from pneumomediastinum which may compromise the central airway. In this case report, we present an unusual case of spontaneous pneumomediastinum and severe subcutaneous emphysema following inhalation of methamphetamine. This case empha

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Khosravi, Navid, Anahita Babaei, Hanieh Azizi, and Hamidreza Samaee. "Vasculitis, Thrombotic Thrombocytopenic Purpura, and Disseminated Intravascular Coagulation Associated With Methamphetamine Intoxication: A Case Report." International Journal of Medical Toxicology and Forensic Medicine 11, no. 4 (2022): 32864. http://dx.doi.org/10.32598/ijmtfm.v11i4.32864.

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Amphetamines and methamphetamines are two groups of substance whose use are increasing globally. Methamphetamines poisoning may develop different sympathetic symptoms; however, developing some complications, such as vasculitis, central nervous system involvement, and kidney injury. In this study, we report a case of methamphetamine poisoning that presented with loss of consciousness and developed Thrombocytopenic Purpura (TTP), Disseminated Intravascular Coagulation (DIC), and pulmonary pseud vasculitis

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Zhao, Yuan-Ling, Wei Zhao, Ming Liu, Lian Liu, and Yun Wang. "TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity." Oxidative Medicine and Cellular Longevity 2020 (November 27, 2020): 1–10. http://dx.doi.org/10.1155/2020/8874304.

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Methamphetamine is a derivative of amphetamines, a highly addictive central stimulant with multiple systemic toxicity including the brain, heart, liver, lung, and spleen. It has adverse effects such as apoptosis and breakdown of the blood-brain barrier. Methamphetamine is a fatal and toxic chemical substance, and its lethal mechanism has been widely studied in recent years. The possible mechanism is that methamphetamine can cause cardiotoxicity and neurotoxicity mainly by inducing oxidative stress so as to generate heat, eliminate people’s hunger and thirst, and maintain a state of excitement

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Edwards, Alexandra Marie, Eric Gregory Johnson, and Andrew C. Bernard. "Intraoperative vasopressor use during emergency surgery on injured meth users." Trauma Surgery & Acute Care Open 5, no. 1 (2020): e000553. http://dx.doi.org/10.1136/tsaco-2020-000553.

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BackgroundMethamphetamine is a growing drug of abuse in America. Patients with recent methamphetamine use pose potential complications to general anesthesia due to changes in hemodynamics and arrhythmias. Limited data exists on the incidence of intraoperative complications on methamphetamine-intoxicated patients requiring urgent or emergent trauma surgery. This study aims to describe intraoperative complications observed in methamphetamine and amphetamine-intoxicated patients requiring emergent surgery.MethodsUsing the Trauma Registry at our ACS-verified level I trauma center, we completed a s

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9

Safdari, Keyvan M., Curtis Converse, Fanglong Dong, et al. "Hemodynamic Effects of Methamphetamine and General Anesthesia." Anesthesiology Research and Practice 2022 (February 17, 2022): 1–8. http://dx.doi.org/10.1155/2022/7542311.

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Study Objective. In our practice, we deal with a significant number of patients who require general anesthesia for elective or semielective surgeries and are positive for illicit methamphetamine. We sought to examine our clinical impression that these patients become hemodynamically unstable under general anesthesia. Design. A retrospective analysis of all anesthetic records at our institution over a two-year period was performed. Setting. Operating room cases under balanced anesthesia. Patients. All patients with ASA class I or II, who did not have trauma or were initially admitted to ICU, ag

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10

Rogers, Jeffrey M., Jennifer E. Iudicello, Maria Cecilia G. Marcondes, et al. "The Combined Effects of Cannabis, Methamphetamine, and HIV on Neurocognition." Viruses 15, no. 3 (2023): 674. http://dx.doi.org/10.3390/v15030674.

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Objective: Methamphetamine and cannabis are two widely used substances among people living with HIV (PLWH). Whereas methamphetamine use has been found to worsen HIV-associated neurocognitive impairment, the effects of combined cannabis and methamphetamine use disorder on neurocognition in PLWH are not understood. In the present study, we aimed to determine the influence of these substance use disorders on neurocognition in PLWH and to explore if methamphetamine-cannabis effects interacted with HIV status. Method and Participants: After completing a comprehensive neurobehavioral assessment, PLW

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Chen, Shubao, Shucai Huang, Cheng Yang, et al. "Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence." International Journal of Neuropsychopharmacology 23, no. 3 (2019): 135–45. http://dx.doi.org/10.1093/ijnp/pyz069.

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Abstract Background Stimulant use and sexual behaviors have been linked in behavioral and epidemiological studies. Although methamphetamine-related neurofunctional differences have been investigated, few studies have examined neural responses to drug and sexual cues with respect to shorter or longer term methamphetamine abstinence in individuals with methamphetamine dependence. Methods Forty-nine men with shorter term methamphetamine abstinence, 50 men with longer term methamphetamine abstinence, and 47 non–drug-using healthy comparison men completed a functional magnetic resonance imaging cue

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Jatuten, Prompiriya, Tawachai Monum, Yutti Amornlertwatana, and Churdsak Jaikang. "Cardiopathology in Methamphetamine Poisoning-Related Deaths in Chiang Mai Thailand." Indian Journal of Forensic Medicine & Toxicology 18, no. 3 (2024): 126–33. http://dx.doi.org/10.37506/2cya1962.

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Background: Blood Methamphetamine levels have been utilized to assess methamphetamine exposure and its toxicity. Heart is a major target organ of methamphetamine intoxication. In some autopsy cases heart pathologies have been revealed at low level of methamphetamine and extensively to be understand a relationship between the blood methamphetamine level and heart pathology. Aim: The aim of this study was to assess the relationship between blood methamphetamine level and heart pathology by using postmortem cases. Methodology: One hundred and twenty medico-legal cases were included and blood meth

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Turkyilmaz, Ilser. "Oral Manifestations of “Meth Mouth”: A Case Report." Journal of Contemporary Dental Practice 11, no. 1 (2010): 73–80. http://dx.doi.org/10.5005/jcdp-11-1-73.

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Abstract Aim The aim of the documentation of this clinical case is to make clinicians aware of “meth mouth” and the medical risks associated with this serious condition. Background Methamphetamine is a very addictive, powerful stimulant that increases wakefulness and physical activity and can produce other effects such as cardiac dysrhythmias, hypertension, hallucinations, and violent behavior. Dental patients abusing methamphetamine can present with poor oral hygiene, xerostomia, rampant caries (“meth mouth”), and excessive tooth wear. Oral rehabilitation of patients using methamphetamine can

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Pavón-León, Patricia, Sealtiel Armenta-Arellano, Betzaida Salas García, Xóchitl De San Jorge Cárdenas, Gaudencio Gutiérrez-Alba, and José Alberto Muños Hernández. "Consumo de metanfetaminas en estudiantes universitarios: prevalencia y factores asociados." Revista Internacional de Investigación en Adicciones 10, no. 2 (2024): 163–73. https://doi.org/10.28931/riiad.2024.2.07.

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Introduction: methamphetamine (MA) trafficking has spread to 117 countries between 2010 and 2020. In Mexico, MA ranked second among illegal drugs in the search for treatment, increasing by 218% between 2018 and 2020 in young people aged 18 to 25. Objective: estimate the prevalence and analyze the factors associated with methamphetamine use among college students. Method: 211 Students pursuing technical and undergraduate degrees of Universidad Veracruzana in the state Veracruz, Mexico, were included. Sociodemographic, academic, illegal drug use, and psychosocial factors were analyzed. Logistic

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Avchalumov, Yosef, Wulfran Trenet, Juan Piña-Crespo, and Chitra Mandyam. "SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD." International Journal of Molecular Sciences 21, no. 18 (2020): 6491. http://dx.doi.org/10.3390/ijms21186491.

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Extended-access methamphetamine self-administration results in unregulated intake of the drug; however, the role of dorsal striatal dopamine D1-like receptors (D1Rs) in the reinforcing properties of methamphetamine under extended-access conditions is unclear. Acute (ex vivo) and chronic (in vivo) methamphetamine exposure induces neuroplastic changes in the dorsal striatum, a critical region implicated in instrumental learning. For example, methamphetamine exposure alters high-frequency stimulation (HFS)-induced long-term depression in the dorsal striatum; however, the effect of methamphetamine

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Zhang, Jimmy, Anh H. Nguyen, Daniel Jilani, et al. "Consecutive treatments of methamphetamine promote the development of cardiac pathological symptoms in zebrafish." PLOS ONE 18, no. 11 (2023): e0294322. http://dx.doi.org/10.1371/journal.pone.0294322.

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Chronic methamphetamine use, a widespread drug epidemic, has been associated with cardiac morphological and electrical remodeling, leading to the development of numerous cardiovascular diseases. While methamphetamine has been documented to induce arrhythmia, most results originate from clinical trials from users who experienced different durations of methamphetamine abuse, providing no documentation on the use of methamphetamine in standardized settings. Additionally, the underlying molecular mechanism on how methamphetamine affects the cardiovascular system remains elusive. A relationship was

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Hay, Gracie L., Sarah J. Baracz, Nicholas A. Everett, et al. "Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats." Journal of Psychopharmacology 32, no. 12 (2018): 1369–78. http://dx.doi.org/10.1177/0269881118799954.

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Background: Methamphetamine is an addictive stimulant that can cause many adverse physical, psychological and psychosocial effects. Preliminary evidence shows cannabidiol, a non-intoxicating constituent of the cannabis plant, may have efficacy in treating opioid and nicotine dependence. However, no study has yet examined whether cannabidiol treatment might impact on methamphetamine addiction. Aims: The current study investigated whether cannabidiol administration reduces the motivation to self-administer methamphetamine and relapse to methamphetamine-seeking behavior following abstinence. Meth

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18

MacKenzie, R. G., and B. Heischober. "Methamphetamine." Pediatrics in Review 18, no. 9 (1997): 305–9. http://dx.doi.org/10.1542/pir.18-9-305.

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19

MacKenzie, Richard G., and Bruce Heischober. "Methamphetamine." Pediatrics In Review 18, no. 9 (1997): 305–9. http://dx.doi.org/10.1542/pir.18.9.305.

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Lappin, Julia M., and Shane Darke. "Methamphetamine." Neurology 93, no. 1 (2019): 13–14. http://dx.doi.org/10.1212/wnl.0000000000007667.

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Havlickova, Tereza, Chrysostomos Charalambous, Marek Lapka, Nina Puskina, Pavel Jerabek, and Magdalena Sustkova-Fiserova. "Ghrelin Receptor Antagonism of Methamphetamine-Induced Conditioned Place Preference and Intravenous Self-Administration in Rats." International Journal of Molecular Sciences 19, no. 10 (2018): 2925. http://dx.doi.org/10.3390/ijms19102925.

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Methamphetamine abuse imposes a significant burden on individuals and society worldwide, and an effective therapy of methamphetamine addiction would provide distinguished social benefits. Ghrelin significantly participates in reinforcing neurobiological mechanisms of stimulants, including amphetamines; thus, ghrelin antagonism is proposed as a promising addiction treatment. The aim of our study was to elucidate whether the pretreatment with growth hormone secretagogue receptor (GHS-R1A) antagonist, substance JMV2959, could reduce the methamphetamine intravenous self-administration (IVSA) and t

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Wright, Jackie, Bob Symons, Jonathon Angell, Kirstin E. Ross, and Stewart Walker. "Current practices underestimate environmental exposures to methamphetamine: inhalation exposures are important." Journal of Exposure Science & Environmental Epidemiology 31, no. 1 (2020): 45–52. http://dx.doi.org/10.1038/s41370-020-00260-x.

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AbstractCurrent practice for determining the exposure to methamphetamine in contaminated homes relies on the analysis of surface wipe sample to address direct contact exposures. The movement of methamphetamine into the air phase, and the potential for inhalation exposures to occur within residential homes contaminated from former clandestine manufacture or smoking of methamphetamine has been generally poorly characterised and understood. All available risk-based guidelines for determining safe levels of methamphetamine in residential properties do not include any consideration of the inhalatio

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Jamshid, Ahmadi. "Fast Treatment of Methamphetamine Related Anxiety and Depressive Disorders: A Novel Approach." Journal of Addiction Medicine and Therapeutic Science 2, no. 1 (2016): 001–3. https://doi.org/10.17352/2455-3484.000011.

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<strong>Background: </strong>Methamphetamine abuse and dependence is currently a considerable problem. <strong>Objective:</strong> To explain the efficacy of buprenorphine in the quick management of methamphetamine related anxiety and depressive disorders and also methamphetamine withdrawal craving. <strong>Results: </strong>52 mg of buprenorphine is very valuable in the treatment of severe methamphetamine related anxiety and depression and also methamphetamine craving. <strong>Discussion: </strong>This study lightens that high dose of buprenorphine is quite effective in the lowering of anxiet

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Chung, *Annie, Yen-Feng Lin, and Ming-Chyi Huang. "ASSOCIATIONS BETWEEN GENETIC LIABILITY TO ATTENTION DEFICIT HYPERACTIVITY DISORDER AND METHAMPHETAMINE ABUSE." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i92. https://doi.org/10.1093/ijnp/pyae059.158.

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Abstract Background Attention deficit hyperactivity disorder (ADHD) and substance use disorder co-occurs frequently. Both methamphetamine abuse and ADHD is heritable and probably highly polygenic. Shared genetic factors may explain the high comorbidity between methamphetamine abuse and ADHD. In this study, we hypothesize methamphetamine abuse may be genetically correlated with ADHD. Aims & Objectives The aim of the study was to examine the association of common genetic variants (i.e., single nucleotide polymorphisms [SNPs]) across the whole genome with methamphetamine abuse and to examine

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Kesby, James P., Ariel Chang, Julia A. Najera, Maria Cecilia G. Marcondes, and Svetlana Semenova. "Brain Reward Function after Chronic and Binge Methamphetamine Regimens in Mice Expressing the HIV-1 TAT Protein." Current HIV Research 17, no. 2 (2019): 126–33. http://dx.doi.org/10.2174/1570162x17666190703165408.

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Background: Methamphetamine abuse and human immunodeficiency virus (HIV) are common comorbidities. HIV-associated proteins, such as the regulatory protein TAT, may contribute to brain reward dysfunction, inducing an altered sensitivity to methamphetamine reward and/or withdrawal in this population. Objective: These studies examined the combined effects of TAT protein expression and, chronic and binge methamphetamine regimens on brain reward function. Methods: Transgenic mice with inducible brain expression of the TAT protein were exposed to either saline, a chronic, or a binge methamphetamine

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Kerry, Gemma L., Kirstin E. Ross, Jackie L. Wright, and G. Stewart Walker. "A Review of Methods Used to Detect Methamphetamine from Indoor Air and Textiles in Confined Spaces." Toxics 10, no. 11 (2022): 710. http://dx.doi.org/10.3390/toxics10110710.

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Methamphetamine manufacture, use, and the resulting contamination is a significant issue that affects public health, the environment, and the economy. Third-hand exposure to methamphetamine can result in adverse health risks for individuals and first responders. Such exposures can result from the inhalation of airborne residues or from contact with contaminated objects. This review was conducted to determine the current methods used for methamphetamine extraction from indoor air and porous fabric materials. Dynamic solid phase microextraction (SPME) and sorbent sampling tubes have been applied

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Kudekar, Deepak Y. "Separation of Methamphetamine from Dimethyl Sulfone by Solubility Differences and Identification, Confirmation by Raman Spectroscopy." International Journal of Forensic Sciences 8, no. 2 (2023): 1–5. http://dx.doi.org/10.23880/ijfsc-16000308.

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Narcotic drug with addition of neutral substances is common practice in India. Paracetamol, phenacetin and lignocaine are commonly used for addition in narcotic drugs like heroin and cocaine. Dimethyl sulfone is a neutral substance used in methamphetamine hydrochloride. Methamphetamine is a stimulant popular in the illicit drug market known as ice drug. The pure crystalline Methamphetamine and Dimethyl sulfone easily detected and identified by Raman spectroscopy. However, mixed Raman spectra was obtained from powdered sample. The identification of methamphetamine in Raman Spectra, was done by

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Y. K. Al-Bayati. "SYNTHESIS, CHARACTERIZATION AND APPLICATION OF MEETHAMPHETAMINE – IMPRINTED POLYMERIC SOLID-PHASE." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 54, no. 4 (2023): 1173–82. http://dx.doi.org/10.36103/ijas.v54i4.1811.

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This study was determine methamphetamine by the addition to the glycidyl methacrylate (GMA) monomer resulting from bulk polymerization formation. To acquire the highest adsorption capacity, molar ratios of the template, monomer, and cross-linking agent, as well as solvents and multiple monomers were investigated. Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) were used to analyze the Methamphetamine polymer. The elution of Methamphetamine had a small effect on the surfaces of the three-dimensional network structure. Methamphetamine was successfully eluted

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TEMİRCAN, Zekeriya. "A neuroimaging study of altered cortical and subcortical volume in adolescent methamphetamine users." Cukurova Medical Journal 48, no. 3 (2023): 1148–56. http://dx.doi.org/10.17826/cumj.1349328.

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Purpose: The aim of this study was is to compare brain structure volume, including cortical and subcortical regions of adolescents- methamphetamine users versus non-users. Materials and Methods: The study was designed to be cross-sectional, and structural magnetic resonance imaging scans were obtained from the participants, including ten methamphetamine users and nine non-users. volBrain program was used to evaluate the images.  Results: The results showed that methamphetamine users altered brain structures- temporal, parietal lobes, nucleus accumbens, amygdala, hippocampus, and th

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Patcharoros, Nontima, Sudsabuy Chulakadabba, Nattawadee Na Manorom, and Vitharon Boon-yasidhi. "Assessing Child Maltreatment in Children Born to Mothers Who Used Methamphetamine during Pregnancy at Siriraj Hospital, Bangkok, Thailand: A Pilot Study." International Scholarly Research Notices 2014 (November 18, 2014): 1–4. http://dx.doi.org/10.1155/2014/406208.

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Studies on maltreatment of children born to methamphetamine abusing mothers are lacking. This cross-sectional study examined child maltreatment among children born at Siriraj Hospital, Bangkok, Thailand, to mothers who used methamphetamines during pregnancy. During the study period between July 2011 and January 2012, 34 caretakers of these children were interviewed using the ISPCAN Child Abuse Screening Tool-Parent Version (ICAST-P) to assess their disciplinary actions. The associations between child’s and caretaker’s characteristics and child maltreatment behaviors were analyzed. More than 90

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Rodriguez, Nancy, Charles Katz, Vincent J. Webb, and David R. Schaefer. "Examining the Impact of Individual, Community, and Market Factors on Methamphetamine Use: A Tale of Two Cities." Journal of Drug Issues 35, no. 4 (2005): 665–93. http://dx.doi.org/10.1177/002204260503500402.

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Although prior studies have monitored the trends in methamphetamine use and reported its increase over the years, few studies have considered how community-level characteristics affect the use of methamphetamine. In this study, we utilize data from the Arrestee Drug Abuse Monitoring (ADAM) program from two cities to examine how individual-level, community-level, and drug market factors influence methamphetamine use. Results indicate that both individual and community-level data significantly influence methamphetamine use. Also, findings show that predictors of methamphetamine use (at the indiv

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Mutumba, Massy, Judith T. Moskowitz, Torsten B. Neilands, Ji-Young Lee, Samantha E. Dilworth, and Adam W. Carrico. "A mindfulness-based, stress and coping model of craving in methamphetamine users." PLOS ONE 16, no. 5 (2021): e0249489. http://dx.doi.org/10.1371/journal.pone.0249489.

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There is increasing interest in the role of mindfulness and mindfulness-based interventions to optimize recovery from a substance use disorder (SUD). However, relatively little is known about the theory-based psychological and social pathways whereby mindfulness could have beneficial effects for managing a chronic, relapsing SUD. Informed by Revised Stress and Coping Theory, the present cross-sectional study examined affective, cognitive, and social pathways whereby mindfulness is associated with lower methamphetamine craving. A total of 161 HIV-positive, methamphetamine-using sexual minority

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Rorabaugh, Boyd R., Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, and Manoranjan S. D'Souza. "Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 4 (2016): H516—H523. http://dx.doi.org/10.1152/ajpheart.00642.2015.

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Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation. Thus the goal of this study was to determine

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Chavva, H., and BR Rorabaugh. "Methamphetamine use during the first or second half of pregnancy worsens cardiac ischemic injury in adult female offspring." Physiological Research 71, no. 4 (2022): 501–8. http://dx.doi.org/10.33549/physiolres.934900.

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There is growing evidence that methamphetamine use during pregnancy may produce detrimental cardiovascular effects in the adult offspring. Prior work demonstrated that chronic methamphetamine exposure throughout the gestational period causes adult female offspring to become hypersensitive to myocardial ischemic injury. The goal of the present study was to determine whether this methamphetamine-induced effect occurs early or late in the gestational period. Pregnant female rats were divided into 4 experimental groups. Groups 1 and 2 received subcutaneous injections of saline (group 1) or methamp

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Thompson, Ronald G., Alison Oliveto, Jeff D. Thostenson, Michael P. Wilson, Janette McGaugh, and Michael J. Mancino. "Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial." Journal of Psychopharmacology 35, no. 11 (2021): 1420–30. http://dx.doi.org/10.1177/02698811211050563.

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Background: The continued increase in prevalence of methamphetamine use in the United States has resulted in a significant increase in the number of patients entering treatment for methamphetamine use. However, no robustly efficacious pharmacologic treatment for methamphetamine use or withdrawal has been identified to date after stopping methamphetamine use. Aims: Given the association between methamphetamine withdrawal and relapse during early treatment, this study tested a controlled d-amphetamine withdrawal paradigm among methamphetamine-using individuals. Methods: Treatment-seeking adults

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Kim, Baeksun, Sung Hyun Tag, Yong Sik Kim, Sung Nam Cho, and Heh-In Im. "Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence." Psychopharmacology 239, no. 3 (2022): 831–40. http://dx.doi.org/10.1007/s00213-022-06074-z.

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Abstract Objective Stimulant use instigates abstinence syndrome in humans. miRNAs are a critical component for the pathophysiology of stimulant abstinence. Here we sought to identify a miRNA marker of methamphetamine abstinence in the circulating extracellular vesicles (cEVs). Methods miR-137 in the cEVs was quantified by qPCR in thirty-seven patients under methamphetamine abstinence and thirty-five age-matched healthy controls recruited from 2014 to 2016 from the general adult population in a hospital setting, Seoul, South Korea. Diagnostic power was evaluated by area under curve in the recei

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Kim, Jang, Shakya, Choi, Jeong, and Lee. "Current Understanding of Methamphetamine-Associated Metabolic Changes Revealed by the Metabolomics Approach." Metabolites 9, no. 10 (2019): 195. http://dx.doi.org/10.3390/metabo9100195.

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Metabolomics is a powerful tool used in the description of metabolic system perturbations caused by diseases or abnormal conditions, and it usually involves qualitative and/or quantitative metabolome determination, accompanied by bioinformatics assessment. Methamphetamine is a psychostimulant with serious abuse potential and due to the absence of effective pharmacotherapy and a high recurrence potential, methamphetamine addiction is a grave issue. Moreover, its addiction mechanisms remain unclear, probably due to the lack of experimental models that reflect personal genetic variances and envir

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Wodarz, Norbert, Anne Krampe-Scheidler, Michael Christ, et al. "Evidence-Based Guidelines for the Pharmacological Management of Acute Methamphetamine-Related Disorders and Toxicity." Pharmacopsychiatry 50, no. 03 (2017): 87–95. http://dx.doi.org/10.1055/s-0042-123752.

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AbstractConsumption of methamphetamine (“crystal”) has spread dramatically over several European countries. The management of methamphetamine-induced acute disorders has become a growing challenge to the health system. Pharmacological treatment strategies for methamphetamine-induced intoxication syndromes, acute withdrawal symptoms, and methamphetamine-induced psychosis are particularly important.The development of interdisciplinary and evidence- and consensus-based (S3) German Guidelines was based on a systematic literature and guideline search on therapeutic interventions in methamphetamine-

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Galloway, Gantt P., Edward G. Singleton, M. Douglas Anglin, et al. "How Long Does Craving Predict Use of Methamphetamine? Assessment of Use One to Seven Weeks after the Assessment of Craving." Substance Abuse: Research and Treatment 1 (January 2008): SART.S775. http://dx.doi.org/10.4137/sart.s775.

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Aims This study lays the foundation for a clinical prediction model based on methamphetamine craving intensity and its ability to predict the presence or absence of within-treatment methamphetamine use. Design We used a random effects logistic approach for estimating repeated-measures, generalized linear mixed models (GLMM) using craving as the sole predictor of methamphetamine. A multivariate GLMM included craving, length of treatment, treatment assignment, and methamphetamine use the previous week as covariates to control for potential confounds. We performed receiver operating characteristi

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Dao, Thuy Thi Dieu, Trang Thu Nguyen, Tam Minh Nguyen, Daniel Feaster, and Giang Minh Le. "Methamphetamine use among people who inject heroin in Hanoi, Vietnam." MedPharmRes 6, no. 1 (2021): 15–21. http://dx.doi.org/10.32895/ump.mpr.6.1.3.

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Introduction: The pattern of drug use in Vietnam has changed rapidly over the past decade, and a large number of people who have a history of heroin injection reportedly use methamphetamine. This paper describes factors associated with methamphetamine use among people who inject heroin in Hanoi, the capital of Vietnam. Methods: This is a cross-sectional survey among 521 heroin injectors who were recruited through chain referral and outreach at community and clinic settings. Eligibility criteria included: (1) male aged 18 or older; (2) reported heroin injecting during the 12 months before the s

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Anari, Leyla, Davood Mehrabani, Mahboobeh Nasiri, Shahrokh Zare, Iman Jamhiri, and Jason Acker. "in Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells." Journal of Pharmacy & Pharmaceutical Sciences 25 (January 10, 2022): 69–76. http://dx.doi.org/10.18433/jpps31843.

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Purpose: Among abused substances, methamphetamine is a psychostimulant drug widely used recreationally with public health importance. This study investigated the effect of methamphetamine on proliferation, differentiation, and apoptosis of human adipose tissue stem cells (AdSCs). Methods: AdSCs were isolated from human abdominal adipose tissue and were characterized for mesenchymal properties and growth kinetics. MTT assay was undertaken to assess methamphetamine toxicity on proliferation and differentiation properties and apoptosis of hAdSCs. Results: Isolated cells were shown to have mesench

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Prakobsrikul, Piyatida, Smith Srisont, Artit Jinawath, and Manee Boonkrem. "Methamphetamine-related post-mortem cases in Bangkok, Thailand." Medicine, Science and the Law 59, no. 3 (2019): 164–70. http://dx.doi.org/10.1177/0025802419852800.

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Introduction This study investigated variables associated with methamphetamine-related deaths in Thailand. Methods This study used data obtained from methamphetamine-related autopsy cases over a six-year period from 2011 to 2016. From the data available during this period, considered variables included: demographic, toxicological and histopathological profiles. Methamphetamine blood concentration calculations and myoglobin immunostainings in kidney samples were also carried out. Statistical analysis and tests of significance were conducted using a paired-sample t-test, adopting a p-value of 0.

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Leonard, Michael Z., Paul Rostin, Kevin P. Hill, Stephanie D. Grabitz, Matthias Eikermann, and Klaus A. Miczek. "The Molecular-Container Calabadion-2 Prevents Methamphetamine-Induced Reinstatement in Rats: A Potential Approach to Relapse Prevention?" International Journal of Neuropsychopharmacology 23, no. 6 (2020): 401–5. http://dx.doi.org/10.1093/ijnp/pyz070.

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Abstract Background Reexposure to methamphetamine with a single “priming dose” can trigger intense cravings and precipitate relapse in methamphetamine-dependent individuals. The acyclic cucurbit[n]uril “molecular container” calabadion-2 shows a high affinity to bind and sequester methamphetamine in vitro and attenuates its locomotor-stimulating effect in rats. The present study investigates whether pretreatment with calabadion-2 is sufficient to prevent the reinstatement of drug seeking by a priming dose of methamphetamine in rats. Methods Male Long-Evans rats were trained to self-administer i

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Callaghan, Russell C., Joey Tavares, Lawren Taylor, and Scott Veldhuizen. "A National Survey of Primary Methamphetamine-Related Admissions to Youth Residential Substance Abuse Treatment Facilities in Canada, 2005 to 2006." Canadian Journal of Psychiatry 52, no. 10 (2007): 684–88. http://dx.doi.org/10.1177/070674370705201009.

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Objective: Adolescent methamphetamine use has become a key issue for Canadian media and governments. Empirical studies, however, have not yet established the national scope of adolescent methamphetamine use or its impact on treatment services in Canada. The objective of the current study was to provide results from a national survey of primary methamphetamine-related admissions to Canadian residential substance abuse treatment facilities for youth. Method: We developed a comprehensive list of all Canadian residential substance abuse treatment facilities for youth, and then, we asked the execut

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Yahyaei, Fariba, Samira Behrad, Raheb Ghorbani, Mehdi Khaksari, and Elham Sadat Afraz. "The effects of berberine hydrochloride on the bone quality in methamphetamine-addicted rats after 3 weeks of withdrawal." Journal of Biological Studies 5, no. 3 (2022): 585–93. http://dx.doi.org/10.62400/jbs.v5i3.7077.

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Animal studies have shown that berberine hydrochloride reduces osteoporosis and has anti-inflammatory effects. The aim of this study was to evaluate the therapeutic effect of berberine hydrochloride on the quality of new bone and the severity of bone inflammation in methamphetamine-addicted rats after 3 weeks of withdrawal. A total of 21 male Wistar rats were divided into 2 groups: control (n = 7), methamphetamine (n = 7), and methamphetamine + berberine groups (n = 7). The 2 addicted groups received water-soluble methamphetamine up to 12 mg/kg for 2 weeks. Subsequently, they were abstinent fo

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Stocco, Marlaina R., Ahmed A. El-Sherbeni, Bin Zhao, Maria Novalen, and Rachel F. Tyndale. "The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization." Psychopharmacology 238, no. 7 (2021): 1791–804. http://dx.doi.org/10.1007/s00213-021-05808-9.

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Abstract Rationale Cytochrome P450 2D (CYP2D) enzymes metabolize many addictive drugs, including methamphetamine. Variable CYP2D metabolism in the brain may alter CNS drug/metabolite concentrations, consequently affecting addiction liability and neuropsychiatric outcomes; components of these can be modeled by behavioral sensitization in rats. Methods To investigate the role of CYP2D in the brain in methamphetamine-induced behavioral sensitization, rats were pretreated centrally with a CYP2D irreversible inhibitor (or vehicle) 20 h prior to each of 7 daily methamphetamine (0.5 mg/kg subcutaneou

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Li, Linghui, Juan Carlos Lopez, Gantt P. Galloway, Matthew J. Baggott, Tom Everhart, and John Mendelson. "Estimating the Intake of Abused Methamphetamines Using Experimenter-Administered Deuterium Labeled R-Methamphetamine: Selection of the R-Methamphetamine Dose." Therapeutic Drug Monitoring 32, no. 4 (2010): 504–7. http://dx.doi.org/10.1097/ftd.0b013e3181db82f2.

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Ricciardelli, Rosemary, Matthew S. Johnston, Katharina Maier, and Lorna Ferguson. "“Jail isn’t the answer for these inmates”: how to respond to methamphetamine use in prisons." International Journal of Prison Health, August 8, 2024. http://dx.doi.org/10.1108/ijoph-12-2023-0084.

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Purpose The correctional system continues to face challenges with responding to and managing methamphetamine use among incarcerated individuals. This study aims to uncover what resources and policies could better help correctional workers deal with these challenges. The authors also examined methamphetamine’s impact on correctional work and staff well-being. Design/methodology/approach An online survey was distributed to correctional workers (n = 269) in Manitoba, Canada, featuring questions about their experiences related to methamphetamine use in populations under their care, what supports a

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Ondocsin, Jeff, Nicole Holm, Sarah G. Mars, and Daniel Ciccarone. "The motives and methods of methamphetamine and ‘heroin’ co-use in West Virginia." Harm Reduction Journal 20, no. 1 (2023). http://dx.doi.org/10.1186/s12954-023-00816-8.

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Abstract Background Opioid and methamphetamine co-use is increasing across the USA with overdoses involving these drugs also rising. West Virginia (WV) has led the US in opioid overdose death rates since at least 2013 and rising co-use of methamphetamine with opioids has played a greater role in deaths over the last 5 years. Methods This study used rapid ethnography to examine methods and motivations behind opioids and methamphetamine co-use from the viewpoint of their consumers. Participants (n = 30) were people who injected heroin/fentanyl also using methamphetamine who participated in semi-

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Faust, Lauren G. "Dysphagia and Methamphetamine Use: Considerations for Speech-Language Pathologists." Perspectives of the ASHA Special Interest Groups, August 31, 2022, 1–9. http://dx.doi.org/10.1044/2022_persp-22-00066.

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Purpose: Methamphetamine use increases the risk of medical conditions that may cause oropharyngeal dysphagia. This tutorial describes what is known about methamphetamine's effects and draws connections to a speech-language pathologist's (SLP's) practice in dysphagia assessment and treatment with this population. Method: Methamphetamine's mechanism of action and prevalence of use are explored. Research in speech-language pathology and related fields such as dentistry, pharmacology, psychology, and public health provides insights into how this drug may impact oropharyngeal swallowing function an

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