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Dissertations / Theses on the topic 'Microbicidal'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Allen, Rebecca G. "Macrophage Microbicidal Activity is Enhanced by Stressor-Exposure." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1324960758.

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2

Hsu, Bryan Boen. "Investigation of microbicidal activity of surface-immobilized hydrophobic polycations." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/62728.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Hydrophobic polycations have been shown to completely kill bacterial, fungal, and viral pathogens, on-contact. Herein we describe advances with this technology on two fronts: (1) innovation of a polycationic-derivative that simplifies the labor-intensive covalent-immobilization procedure, and (2) elucidation of the current mechanistic understanding of this phenomenon. First, we developed and characterized a novel polycationic polyme

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3

Curfman, Christopher L. "Micellar properties of spermicidal and microbicidal quaternary ammonium surfactants." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-03042009-041158/.

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4

Gomes, Clayson Moura. "Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5489.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-18T14:57:11Z No. of bitstreams: 2 Tese - Clayson Moura Gomes - 2015.pdf: 2080474 bytes, checksum: e53c02c9eac98545d091fb13331c2b9a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-18T14:58:58Z (GMT) No. of bitstreams: 2 Tese - Clayson Moura Gomes - 2015.pdf: 2080474 bytes, checksum: e53c02c9eac98545d091fb13331c2b9a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Made available in

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5

Lima, Tatiane Soares de. "Caracterização das ações do veneno de Crotalus durissus terrificus sobre funções de neutrófilos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-21022011-132634/.

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Estudos anteriores demonstraram que o veneno de Crotalus durissus terrificus (VCdt) apresenta ação antiinflamatória prolongada, bem como inibe o espraiamento e a atividade fagocítica de macrófagos peritoneais, sendo a crotoxina (CTX), o principal componente do VCdt, a responsável por esses efeitos. Em relação aos neutrófilos, demonstrou-se que o VCdt inibe, in vitro e in vivo, a fagocitose por essas células, porém o componente do VCdt responsável por esse efeito não foi identificado. Dessa forma, o objetivo desse estudo foi identificar o componente responsável pelo efeito inibitório do VCdt so

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6

Kilelee, Erin M. "Modeling the interaction of the platelet microbicidal protein tPMP-1 with the cell membrane." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-3/r3/kileleee/erinkilelee.pdf.

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7

Zhang, Jinya. "Unmasking the microbicidal and immunostimulatory properties of warthog fecal microbiota in vitro and in vivo." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670999.

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El virus de la Pesta Porcina Africana (VPPA) és l’amenaça principal per a la indústria porcina. L’absència de vacunes enfront del virus complica el control i erradicació de la malaltia que provoca: la Pesta Porcina Africana (PPA). El VPPA infecta tant a porcs domèstics com a senglars euroasiàtics (ambdós Sus Scrofa), cursant amb diferents quadres clínics, que varien des de la PPA aguda o hiperaguda, amb taxes de mortalitat de fins al 100%, fins a la infecció crònica. Malgrat el VPPA és capaç d’infectar també als porcs salvatges africans, incloent al facoquer, el virus no provoca signes clínics

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8

Mawela, Kedibone Gloria. "Evaluation of RANTES analogue expression in Nicotiana benthamiana and Lycopersicon esculentum and their topical microbicidal activity." Thesis, University of Pretoria, 2013. http://hdl.handle.net/2263/32946.

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The HIV/AIDS pandemic has dramatically altered patterns of morbidity and mortality in sub-Saharan Africa during the last two decades. In the absence of HIV vaccine, microbicides may offer viable option for protection against HIV infection. Microbicides are products that are applied topically inside the vagina or rectum that act to impede transmission of HIV and other sexually transmitted diseases. Small human chemokines such as RANTES (regulated upon activation, normal T cell expressed and secreted) are currently been investigated as microbicides candidates. A number of N-terminally mod

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9

Palaniappan, Sevugan. "Ohmic heating of foods : studies on microbicidal effect of electricity, electrical conductivity of foods, and heat transfer in liquid- particle mixtures /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487757723995203.

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10

Fontoura, Juliana Tolfo da. "Desempenho de microbicidas para preservação de peles e couros." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/96481.

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Um problema na indústria coureira é a deterioração de peles e couros devido ao desenvolvimento de microrganismos no processamento do couro. As peles e os couros contêm nutrientes adequados para o crescimento de microrganismos, como carboidratos, gorduras e proteínas, além das condições ambientais, alta umidade, temperatura de armazenagem e pH favoráveis. Alguns gêneros de bactérias e fungos sintetizam importantes substâncias deste substrato, causando modificações prejudiciais na superfície do couro e nas propriedades físico-mecânicas, deixando manchas pigmentadas de difícil remoção, afetando a

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11

Montagut, Pérez Ana Maria. "Nuevos colorantes hidrofóbicos aplicados a la tinción de tejidos. Materiales modificados con nanopartículas de plata y antibióticos." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457905.

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Las superficies hidrofóbicas artificiales tienen un gran potencial en una amplia gama de aplicaciones industriales debido a sus propiedades de auto-limpieza, anti-incrustación biológica, anti-empañamiento, anti-adherencia, anti-corrosión y anti-contaminación. Los materiales con propiedades hidrófobas son de gran interés para textiles con propiedades hidrófugas y oleofóbicas. Hemos sintetizado diferentes derivados nuevos de Índigo y triarilmetano (TAM) que añaden a sus estructuras cadenas largas polifluorados o hidrocarbonadas, con el fin de promover su hidrofobicidad. Hemos teñido telas de al

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12

Cunha, Luciane Tavares da. "Estudo da interação da alga Prototheca zopfii com neutrófilos recuperados de leite bovino e ação do sistema AIA/HRP sobre este patógeno." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-29092010-140242/.

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Estudos têm mostrado a incidência de mastite bovina associada à alga Prototheca zopfii. O objetivo deste trabalho foi estudar a interação da P. zopfii com neutrófilos recuperados de leite bovino e avaliar o efeito do sistema ácido indol-3-acético/peroxidase de raiz forte (AIA/HRP) sobre a viabilidade deste microrganismo em experimentos in vitro. A P. zopfii foi recuperada de vacas com mastite clínica e, no laboratório, foram realizadas a caracterização molecular, morfológica e crescimento exponencial do microrganismo. Em seguida, neutrófilos recuperados de leite bovino foram incubados na ausên

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13

Toner, C. F. "Controlled intravaginal delivery of HIV microbicides." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419413.

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14

Fasolo, Alba. "Studi sui meccanismi microbicidi dei neutrofili. Ruolo dei canali protonici voltaggio-dipendenti nella regolazione del metabolismo ossidativo. Impiego di farmaci lisosomotropici per la correzione del difetto di attività microbicida nella malattia granulomatosa cronica." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7870.

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2010/2011<br>Ruolo dei canali protonici voltaggio-dipendenti nella regolazione del metabolismo ossidativo Durante il burst respiratorio (RB) conseguente alla loro attivazione, i neutrofili producono specie reattive dell’ossigeno (ROS) indispensabili per l’uccisione dei microrganismi fagocitati. La produzione di ROS è mediata dalla NADPH ossidasi, un complesso enzimatico multimerico che si assembla sulla membrana dei fagociti. Diversi studi hanno suggerito che durante il RB l’attivazione della NADPH ossidasi causa una fuoriuscita di elettroni sotto forma di anione superossido (O2-) accompagn

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15

Sabalza, Gallués Maite. "Maize seeds as a production and delivery platform for HIV microbicides." Doctoral thesis, Universitat de Lleida, 2013. http://hdl.handle.net/10803/127189.

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La infecció pel virus de la immunodeficiència humana (VIH), és un dels problemes sanitaris i de desenvolupament més greus del món actual. Evitar la infecció és una de les estratègies que podria ajudar a reduir l’expansió del virus. Els microbicides són una nova classe de fàrmacs que podrien ajudar a realitzar-ho. Alguns dels reptes a superar que podrien frenar el desenvolupament de microbicides efectius son: que les molècules resultants siguin efectives, que la producció es pugui ampliar ràpidament i que els costos de producció puguin ser reduïts. Un dels sistemes de producció més prometedors

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16

Fletcher, Patricia Susan. "Mucosal HIV-1 infection : mechanisms and microbicides." Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432894.

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17

Madeira, Luisa de Moraes. "Expressão de Cyanovirin-N, um microbicida anti-HIV, em plantas." reponame:Repositório Institucional da UnB, 2008. http://repositorio.unb.br/handle/10482/4007.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2008.<br>Submitted by samara castro (sammy_roberta7@hotmail.com) on 2010-03-15T14:34:35Z No. of bitstreams: 1 2008_LuisaMoraesMadeira.pdf: 2638517 bytes, checksum: b53aabdfebbae7e32f27d2d1d35406cd (MD5)<br>Approved for entry into archive by Joanita Pereira(joanita) on 2010-03-18T17:56:15Z (GMT) No. of bitstreams: 1 2008_LuisaMoraesMadeira.pdf: 2638517 bytes, checksum: b53aabdfebbae7e32f27d2d1d35406cd (MD5)<br>Made available in DSpace on 2010-03-18T17:56:15Z (GMT). No. of bit

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18

Lowry, Deborah. "Sustained release strategies for HIV microbicides and vaccines." Thesis, Queen's University Belfast, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486247.

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Human immunodeficiency virus (HIV) lolls more people worldwide than' any other infectious disease. The main mode of transmission of HN is unprotected heterose~al intercourse with an infected partner. There is a need for the development of female controlfed preventative strategies. the most promising approach currently being pursued is the development of vaginally administeled HN. microbicides. The release profiles from silicone intravaginal rings (lVRs) of (i) potential HN fusion inhibitors. dextran sulfate (OS) and ceJJuJose sulfate (CS). (ii) organic acid species, and .(iii) bovine serum alb

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19

LOPES, Tamyris Regina Matos. "Avaliação do potencial microbicida das folhas da espécie Ayapana triplinervis Vahl." Universidade Federal do Pará, 2013. http://repositorio.ufpa.br/jspui/handle/2011/6150.

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Submitted by Cleide Dantas (cleidedantas@ufpa.br) on 2014-12-10T00:11:12Z No. of bitstreams: 2 license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Dissertacao_AvaliacaoPotencialMicrobicida.pdf: 2937381 bytes, checksum: 7a4f1498597c6eb85a59a088c3577ee3 (MD5)<br>Approved for entry into archive by Ana Rosa Silva (arosa@ufpa.br) on 2014-12-11T14:47:37Z (GMT) No. of bitstreams: 2 license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Dissertacao_AvaliacaoPotencialMicrobicida.pdf: 2937381 bytes, checksum: 7a4f1498597c6eb85a59a088c3577ee3 (MD5)<br>Made

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20

McGowan, Ian. "The clinical development of rectal microbicides for HIV prevention." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/16573/.

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Introduction: Individuals practicing unprotected receptive anal intercourse are at particularly high risk of HIV infection. Men who have sex with men in the developed and developing world continue to have disproportionate and increasing levels of HIV infection. The last few years have seen important progress in demonstrating the efficacy of oral pre-exposure prophylaxis, vaginal microbicides, and treatment as prevention but there has also been significant progress in the development of rectal microbicides. The purpose of this thesis is to summarise the status of rectal microbicide research, to

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21

Fowler, Katherine Elizabeth. "Characterisation of microbicide-mediated inhibition of HIV-1 infection." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424837.

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22

Tu, Sheng. "Syntheses of Multi-headed, Two-tailed, Anionic Surfactants as Topical Microbicides." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/40819.

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The purpose of this research was to design and develop a facile synthesis of a series of multi-headed, two-tailed anionic surfactants (3CAm1(n)2) as anti-HIV microbicides, and to compare the biological activities of these compounds to the activities of their straight-acyl chain derivatives. The synthesis requires coupling reaction of dialkylacetic acid (R2CHCOOH) (R2= n-C6H13, n-C7H15, n-C8H17, n-C9H19, n-C10H21) and Beheraâ s amine (H2NC(CH2CH2COOtBu)3). Commercially available diethyl malonate and straight chain alkyl bromide were selected to produce dialkylacetic acid. Sodium methoxide (

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23

Wallace, Gregory Stephen. "Pre-clinical development of microbicides against mucosal HIV-1 infection." Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439366.

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24

Gafos, Mitzy. "Microbicides, sexuality and sexual health in KwaZulu-Natal, South Africa." Thesis, City University London, 2013. http://openaccess.city.ac.uk/2987/.

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There is an urgent need for additional HIV prevention options for women. Evidence supporting the benefit of microbicides in reducing the risk of vaginally acquired HIV acquisition has provided a major breakthrough. Despite the wealth of evidence supporting microbicide acceptability in Africa, there are still gaps in our understanding about how women will incorporate microbicides into their everyday lives. In this thesis I examine whether vaginal microbicides are compatible with socio-cultural norms regarding sexuality and sexual health in a predominantly rural area of KwaZulu-Natal, South Afri

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25

Lima, Heliton Gustavo de. "Mecanismos de defesa dos mastócitos contra o periodontopatógeno Aggregatibacter actinomycetemcomitans: atividade microbicida intracelular." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-03022016-152747/.

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Os mastócitos (MCs) estão presentes tanto no periodonto normal quanto inflamado, em diferentes quantidades e em vários locais. Nos últimos anos, a eficácia e a contribuição dos MCs em eliminar bactérias, através de sua atividade microbicida intracelular, estão se tornando cada vez mais reconhecidas. Assim, a partir de MCs murinos desafiados in vitro com o periodontopatógeno Aggregatibacter actinomycetemcomitans (ATCC 29523) por 3, 5, 10 e 24 horas, o presente estudo teve como objetivo investigar a capacidade microbicida intracelular de MCs, e comparar com a capacidade microbicida de macrófago

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26

Rebech, Gabriela Torres. "PD-1 regula a atividade microbicida de leucócitos esplênicos na leishmaniose visceral canina." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153959.

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Macri, Juliana Aparecida. "Atividade imunomoduladora, microbicida e mecanismo de ação do ácido caurenóico na leishmaniose experimental." Universidade Estadual de Londrina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Patologia Experimental, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000198349.

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A infecção por Leishmania (Leishmania) amazonensis pode causar lesões locais e graves nos seres humanos, sendo esta condição clínica conhecida como leishmaniose tegumentar americana (LTA). Atualmente, a LTA continua sendo uma doença negligenciada além de não possuir uma terapêutica eficaz. O ácido caurenóico (AC) é um diterpeno presente em diversas plantas, dentre elas a Sphagneticola trilobata (L.) pruski. Diversos efeitos biológicos deste composto já foi comprovado em diferentes modelos experimentais, dentre eles destaca-se a ação antiparasitaria, anti-inflamatória e analgésica. Neste trab

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Rossi, Kaymerê Bispo. "Participação da apolipoproteína-E na atividade microbicida “in vitro” contra o Mycobacterium tuberculosis." reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1490.

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Submitted by Maykon Nascimento (maykon.albani@hotmail.com) on 2015-08-18T17:52:28Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Participacao da apolipoproteina E na atividade microbicida in vitro contra o Mycobacterium tuberculosis.pdf: 1715784 bytes, checksum: 67066f843ccafe272634d4cea98ab7ef (MD5)<br>Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2015-08-19T13:14:49Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Participacao da apolipoproteina E na

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ROSSI, K. B. "Participação da Apolipoproteína-e na Atividade Microbicida in Vitro Contra o Mycobacterium Tuberculosis." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4582.

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Made available in DSpace on 2016-08-29T15:34:59Z (GMT). No. of bitstreams: 1 tese_8103_Dissertação Kaymerê Final Corrigida.pdf: 1721673 bytes, checksum: 349a8b28df3024da428191034c651c47 (MD5) Previous issue date: 2014-08-29<br>A parede celular de Mycobacterium tuberculosis (Mtb) é constituída por 60% de lipídios, impedindo a passagem de uma grande quantidade de substâncias, além de desempenhar um importante papel na munopatogênese. A apresentação desses antígenos aos linfócitos se dá por meio de moléculas do tipo CD1. Por sua vez a Apolipoproteína-E (ApoE), glicoproteína amplamente distribu

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Alrushaid, Samaa. "Chemical reactivity and biological activity of bethoxazin, an industrial microbicide." Bioorganic & Medicinal Chemistry, 2012. http://hdl.handle.net/1993/23627.

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Bethoxazin is a broad spectrum industrial biocide with commercial applications as a material preservative; however its mechanism of action has not been investigated. In this study, the chemical reactivity of bethoxazin towards biologically important nucleophiles was assessed with UV-Vis spectroscopy. Bethoxazin reacted with molecules containing free sulfhydryl groups such as glutathione and human serum albumin but not with amino, acetate or phenol containing compounds. Bethoxazin was shown to potently inhibit the growth of the K562 human cancer cell line with an IC50 value in the micromolar ra

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Morris, Georgina Claire. "MABGEL 1 : C2F5, C4E10 & C2G12 as a vaginal microbicide." Thesis, University of Hull, 2012. http://hydra.hull.ac.uk/resources/hull:7126.

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Topical microbicides are being developed as a female-controlled method for preventing HIV-1 infection. Non-antiretroviral (ARV)-based candidates may be advantageous given increasing levels of ARV resistance in low and middle- income countries. MABGEL 1 was a phase 1 trial designed to evaluate the pharmacokinetics and safety of a vaginal microbicide containing the broadly HIV-1 neutralizing monoclonal antibodies (mAbs) C2F5, C4E10 and C2G12 in a hydroxyethylcellulose-based gel vehicle. It was the first study of topical mAb application to the human female genital tract. Twenty-eight healthy wome

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Swedrowska, Magda. "Optimising combinatorial microbicide delivery for prevention of colorectal HIV infection." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/optimising-combinatorial-microbicide-delivery-for-prevention-of-colorectal-hiv-infection(7c79ea38-3292-41c7-8016-d9d6d7e80edd).html.

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A combination of antiretroviral drugs, tenofovir, dapivirine and darunavir, provide enhanced antiviral activity compared to a single agent when tested in-vitro. However, the impact of co-formulation on drug absorption after topical delivery to the colorectal mucosa is unclear, and methods are required to screen for drug-drug interactions. The main aim of this project was to establish methods to determine drug transport mechanisms and interactions of three antiretroviral drugs for colorectal topical delivery to permit the rational composition of an optimized formulation. The first stage of the

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33

Harries, Jane. "A gendered perspective of a community's perception of microbicide introduction." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/8645.

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Includes bibliographical references.<br>South Africa is currently experiencing one of the worst HIV/AIDS epidemics in the world. The epidemic features distinctive age and gender distributions, with young women at greatest risk, and overall proportionally more women affected than men. Current HIV prevention strategies are limited as women's risk is frequently derived from their partners' behaviours rather than their own. The development of a microbicide for HIV prevention may offer the possibility of reducing women’s risk of infection in situations where other more effective methods cannot be u

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Turner, Dafydd Paul. "An investigation into the physico-chemical parameters determining the performance of silica encapsulated biocides in paints and coatings." Thesis, Manchester Metropolitan University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326249.

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35

Vamvaka, Evangelia. "Rice endosperm as a production platform for third-generation HIV microbicides." Doctoral thesis, Universitat de Lleida, 2014. http://hdl.handle.net/10803/285629.

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L’objectiu de la meva tesis doctoral és la producció en l’endosperma de l’arròs d’una tercera generació de microbicides contra el virus de la sida. Durant la meva recerca he utilitzat l’anticòs monoclonal 2G12 i dues proteïnes que neutralitzen el virus de la sida CV-N i GRFT, soles o en combinació, per a descobrir noves estratègies de producció. En la primera part he investigat si podia produir 2G12 a l’endosperma de l’arròs i quins eren els factors que influenciaven la seva producció. En la segona part de la meva tesis he introduït GRFT a l’endosperma de l’arròs i he analitzat si la proteïna

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Roy, Sylvie. "Développement de microbicides topiques pour la prévention des maladies transmises sexuellement." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ57888.pdf.

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Stefanidou, Martha. "A multi-targeted approach to microbicides against mucosal HIV-1 transmission." Thesis, St George's, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511962.

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Hardrict, Shauntrece Nicole. "Dendronized Amphiphilic Copolymers Synthesized from Methacrylate Derivatives as Potential Topical Microbicides." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29903.

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The need for a preventative agent to curtail the rampant spread of HIV, other STDs and mucosal pathogens is urgent. Topical microbicides based on amphiphilic compounds have been identified as an attractive means toward this goal. Novel dendritic methacrylate macromonomers––di-tert-butyl 4-(2-tert-butoxycarbonyl-ethyl)-4-[3-(2-methacryoloxyethyl)ureido]heptandioate (MI) and di-tert-butyl 4-(2-tert-butoxycarbonylethyl)-4-[3-methyl-3-(2-methacryoloxyethyl)ureido]heptanedioate (MIII)––were synthesized, characterized, and subsequently polymerized via conventional free radical polymerization in acet

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Steele, Matthew Stephen. "Male microbicides, genital hygiene, and HIV risk behavior among Kenyan men /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6434.

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Wilson, Nnenna Jean. "Differences in Preferences for Using Microbicides Among Gay Men Seeking Internet." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2432.

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Efforts to reduce the spread of human immunodeficiency virus (HIV) and find innovative alternatives to condom use are important public health challenges. While the incidence of HIV is leveling off among some populations, it is escalating in other populations such as young African American men who have sex with men (MSM). Guided by the health belief model (HBM) and the AIDS risk reduction model (ARRM), this quantitative, cross-sectional study sought to use multiple linear regression, binary logistic regression, and Fisher's exact test to determine how perceived susceptibility, as measured by th

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Figueiredo, Bárbara Bruna Muniz. "Efeito da vitamina D na atividade microbicida de macrófagos a linhagens de Mycobacterium bovis." Universidade Federal de Juiz de Fora (UFJF), 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/2352.

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Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2016-08-16T15:20:59Z No. of bitstreams: 1 barbarabrunamunizfiqueiredo.pdf: 1234783 bytes, checksum: b2e6590135c597d4befcbab1e5b68fe1 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-08-17T13:05:50Z (GMT) No. of bitstreams: 1 barbarabrunamunizfiqueiredo.pdf: 1234783 bytes, checksum: b2e6590135c597d4befcbab1e5b68fe1 (MD5)<br>Made available in DSpace on 2016-08-17T13:05:50Z (GMT). No. of bitstreams: 1 barbarabrunamunizfiqueiredo.pdf: 1234783 bytes, checksum: b2e6590135c597d

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Junior, João Francisco Lucon. "Avaliação da atividade microbicida de extratos vegetais sobre Staphylococcus aureus isolados de mastite bovina." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-16092013-093144/.

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A resistência bacteriana é responsável perante o fracasso no tratamento de infecções com agentes quimioterápicos. São necessárias novas alternativas para controlar estes micro-organismos. Entre essas alternativas estão plantas utilizadas tradicionalmente na medicina popular. O presente trabalho avaliou a eficiência dos extratos etanólicos e acetonicos de folhas de Cecropia pachystachya e Curatella americana com atividade antibacteriana in vitro em cepas de Staphylococcus aureus isolado de caso de mastite bovina. Os extratos de C. pachystachya e C. americana apresentam MIC de 2,5 mg.mL-1. O com

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Miller, L. "Without directly observed sex, what's a microbicide trialist to do? : adherence and adherence measurement as a clinical trial design issue in vaginal microbicide trials for HIV prevention." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/3817569/.

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This research examined past microbicide effectiveness trials to better understand how adherence and adherence assessment could be improved in future vaginal microbicide trial design. No product is currently available despite decades of clinical trials of candidate microbicides, yet the need for women to have a method to reduce their risk of sexual transmission of HIV that does not rely on male partner agreement remains urgent. Low product adherence and inaccurate adherence reporting has inhibited the ability of trials to accurately assess the biological efficacy of candidate products. Methods

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Mcconville, C. M. C. "Development of silicone customer delivery systems for sustained release of HIV microbicides." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517358.

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Aquino, Daniela Sant’ Ana de. "Avaliação do efeito microbicida da filosseptina-1 nas formas amastigotas de Leishmania amazonensis in vitro." reponame:Repositório Institucional da UnB, 2014. http://repositorio.unb.br/handle/10482/16879.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Núcleo de Medicina Tropical, 2014.<br>Submitted by Larissa Stefane Vieira Rodrigues (larissarodrigues@bce.unb.br) on 2014-11-12T17:32:39Z No. of bitstreams: 1 2014_DanielaSant’AnaDeAquino.pdf: 6175557 bytes, checksum: 26a02e952ac55ed41bf830fd604fe0c9 (MD5)<br>Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2014-11-14T13:15:18Z (GMT) No. of bitstreams: 1 2014_DanielaSant’AnaDeAquino.pdf: 6175557 bytes, checksum: 26a02e952ac55ed41bf830fd604fe0c9 (MD5)<br>Made available in DSpace on 2014-11-14T13:15

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Oulé, Kégnon Mathias. "Effet microbicide du CO¦2 sous pression, nouveau procédé de conservation d'aliments." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0031/NQ65425.pdf.

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Blanco, Perera Amaya. "Plant-produced microbicides against the human immunodeficiency and severe acute respiratory symptom viruses." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/673001.

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La meva dissertació es centra en l'avaluació de l'activitat antiviral de microbicides recombinats en l'endosperma d'arròs transgènic, seguida d'estudis per millorar el rendiment mitjançant una reprogramació epigenètica i per avaluar la productivitat en condicions de camp. Els microbicides assajats van ser les lectines SD1 i cianovirina-N (CV-N). SD1 es va expressar sola i CV-N en un microbicida de triple combinació (generada anteriorment) que també contenia l'anticos monoclonal 2G12 i la lectina griffithsin (GRFT}. Inicialment vaig avaluar l'expressió de SD1 per determinar si l'endosperma

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Smith, Kieron A. "The role of drug transporters in development of optimised microbicides against HIV-1." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231840.

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Due to the lack of an effective cure for human immunodeficiency virus (HIV-1), with approximately twenty million new infections expected by 2031, research has moved towards optimised prevention strategies. Drug transporters, characterised extensively in the human liver, kidney and gastrointestinal tract, can be manipulated to improve the pharmacokinetic properties of orally delivered anti-retrovirals (ARV's). There is paucity in knowledge of drug transporter expression in the human cervicovaginal (CV) tract and representative pre-clinical models, where characterisation and manipulation may ena

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Santos, Severo Maiara. "Função microbicida de macrófagos alveolares de ratos submetidos à desnutrição neonatal: estudo da infecção celular, in vitro, por Staphylococcus aureus meticilina sensível e meticilina resistente." Universidade Federal de Pernambuco, 2009. https://repositorio.ufpe.br/handle/123456789/7221.

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Made available in DSpace on 2014-06-12T18:30:09Z (GMT). No. of bitstreams: 2 arquivo3547_1.pdf: 2312976 bytes, checksum: c87799a66031646002629814fe3026bf (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2009<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Staphylococcus aureus resistentes à meticilina têm aumentado de forma significativa nos últimos anos, sendo importante problema de saúde pública, como também, a desnutrição, ainda presente em nosso país. Assim, torna-se importante avaliar repercussões da desnutrição ne

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Barreto, Aline Silva. "Participação do CD40-L Solúvel (sCD40-L) na resposta microbicida de macrófagos infectados por Leishmania chagasi." Pós-Graduação em Biologia Parasitária, 2014. https://ri.ufs.br/handle/riufs/3259.

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Visceral Leishmaniasis (VL) is a severe desease, endemic in the Brazil, with a tendency to be more prevalent in urban areas. The pathology of VL is associated with a reduced production of IFN-. by T-cells and the increased production of IL-10, which suppresses the activation of macrophages and promotes development of the disease. Activated T cells can express CD40L interacting with CD40 expressed on antigen presenting cells (APC), this interaction is important for the activation of APCs and production of inflammatory cytokines, chemokines, nitric oxide (NO) and metalloproteinases, triggering a

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