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Journal articles on the topic 'Microfluidics'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Shi, Yuxing, Peng Ye, Kuojun Yang, et al. "Application of Microfluidics in Immunoassay: Recent Advancements." Journal of Healthcare Engineering 2021 (July 15, 2021): 1–24. http://dx.doi.org/10.1155/2021/2959843.

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In recent years, point-of-care testing has played an important role in immunoassay, biochemical analysis, and molecular diagnosis, especially in low-resource settings. Among various point-of-care-testing platforms, microfluidic chips have many outstanding advantages. Microfluidic chip applies the technology of miniaturizing conventional laboratory which enables the whole biochemical process including reagent loading, reaction, separation, and detection on the microchip. As a result, microfluidic platform has become a hotspot of research in the fields of food safety, health care, and environmen

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Ajikumar, Arjun, and Kin Fong Lei. "Microfluidic Technologies in Advancing Cancer Research." Micromachines 15, no. 12 (2024): 1444. http://dx.doi.org/10.3390/mi15121444.

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This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particu

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3

Savitri, Goparaju. "Advancement in Generation and Application of Microfluidic Chip Technology." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 2 (2024): 7277–98. http://dx.doi.org/10.37285/ijpsn.2024.17.2.9.

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Microfluidics is an interdisciplinary topic of research that draws inspiration from other areas such as fluid dynamics, microelectronics, materials science, and physics. Microfluidics has made it possible to create microscale channels and chambers out of a broad variety of materials by borrowing ideas from a number of different fields. This has opened up exciting possibilities for the development of platforms of any size, shape, and geometry using a variety of approaches. One of the most significant advantages of microfluidics is its versatility in applications. Microfluidic chips can be used

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McMillan, Kay S., Marie Boyd, and Michele Zagnoni. "Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids." Lab on a Chip 16, no. 18 (2016): 3548–57. http://dx.doi.org/10.1039/c6lc00884d.

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We present a new microfluidic protocol for spheroid based assays that combines the compartmentalisation properties of droplet microfluidics with controllable perfusion typical of single-phase microfluidics.

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Fallahi, Hedieh, Jun Zhang, Hoang-Phuong Phan, and Nam-Trung Nguyen. "Flexible Microfluidics: Fundamentals, Recent Developments, and Applications." Micromachines 10, no. 12 (2019): 830. http://dx.doi.org/10.3390/mi10120830.

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Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they be

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Shih, Steve C. C., Philip C. Gach, Jess Sustarich, et al. "A droplet-to-digital (D2D) microfluidic device for single cell assays." Lab on a Chip 15, no. 1 (2015): 225–36. http://dx.doi.org/10.1039/c4lc00794h.

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Marzban, Mostapha, Ehsan Yazdanpanah Moghadam, Javad Dargahi, and Muthukumaran Packirisamy. "Microfabrication Bonding Process Optimization for a 3D Multi-Layer PDMS Suspended Microfluidics." Applied Sciences 12, no. 9 (2022): 4626. http://dx.doi.org/10.3390/app12094626.

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Microfluidic systems have received increased attention due to their wide variety of applications, from chemical sensing to biological detection to medical analysis. Microfluidics used to be fabricated by using etching techniques that required cleanroom and aggressive chemicals. However, another microfluidic fabrication technique, namely, soft lithography, is less expensive and safer compared to former techniques. Polydimethylsiloxane (PDMS) has been widely employed as a fabrication material in microfluidics by using soft lithography as it is transparent, soft, bio-compatible, and inexpensive.

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Qi, Ping, Jin Lv, Xiangdong Yan, Liuhui Bai, and Lei Zhang. "Microfluidics: Insights into Intestinal Microorganisms." Microorganisms 11, no. 5 (2023): 1134. http://dx.doi.org/10.3390/microorganisms11051134.

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Microfluidics is a system involving the treatment or manipulation of microscale (10−9 to 10−18 L) fluids using microchannels (10 to 100 μm) contained on a microfluidic chip. Among the different methodologies used to study intestinal microorganisms, new methods based on microfluidic technology have been receiving increasing attention in recent years. The intestinal tracts of animals are populated by a vast array of microorganisms that have been established to play diverse functional roles beneficial to host physiology. This review is the first comprehensive coverage of the application of microf

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Liu, Jingji, Boyang Zhang, Yajun Zhang, and Yiqiang Fan. "Fluid control with hydrophobic pillars in paper-based microfluidics." Journal of Micromechanics and Microengineering 31, no. 12 (2021): 127002. http://dx.doi.org/10.1088/1361-6439/ac35c9.

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Abstract Paper-based microfluidics has been widely used in chemical and medical analysis applications. In the conventional paper-based microfluidic approach, fluid is propagating inside the porous structure, and the flow direction of the fluid propagation is usually controlled with the pre-defined hydrophobic barrier (e.g. wax). However, the fluid propagation velocity inside the paper-based microfluidic devices largely depends on the material properties of paper and fluid, the relative control method is rarely reported. In this study, a fluid propagation velocity control method is proposed for

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Prajitna, Stefanus H., Christian Harito, and Brian Yuliarto. "Cost-Effective Manufacturing of Microfluidics Through the Utilization of Direct Ink Writing." Emerging Science Journal 9, no. 1 (2025): 1–11. https://doi.org/10.28991/esj-2025-09-01-01.

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Microfluidics is essential for precise manipulation of fluids in small channels. However, conventional manufacturing processes for microfluidic devices are expensive, time-consuming, and require specialized equipment in a clean room. While recent studies have improved the cost-effectiveness of this device, there is still a need for further advancement in cost efficiency. Therefore, this study aimed to develop a custom-built direct-ink writing (DIW) printer for manufacturing microfluidic devices that is more affordable. Custom-built DIW directly printed microfluidic channels onto microscope sli

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Li, Xiangke, Meng Wang, Thomas P. Davis, Liwen Zhang, and Ruirui Qiao. "Advancing Tissue Culture with Light-Driven 3D-Printed Microfluidic Devices." Biosensors 14, no. 6 (2024): 301. http://dx.doi.org/10.3390/bios14060301.

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Three-dimensional (3D) printing presents a compelling alternative for fabricating microfluidic devices, circumventing certain limitations associated with traditional soft lithography methods. Microfluidics play a crucial role in the biomedical sciences, particularly in the creation of tissue spheroids and pharmaceutical research. Among the various 3D printing techniques, light-driven methods such as stereolithography (SLA), digital light processing (DLP), and photopolymer inkjet printing have gained prominence in microfluidics due to their rapid prototyping capabilities, high-resolution printi

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Tsai, Hsieh-Fu, Soumyajit Podder, and Pin-Yuan Chen. "Microsystem Advances through Integration with Artificial Intelligence." Micromachines 14, no. 4 (2023): 826. http://dx.doi.org/10.3390/mi14040826.

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Microfluidics is a rapidly growing discipline that involves studying and manipulating fluids at reduced length scale and volume, typically on the scale of micro- or nanoliters. Under the reduced length scale and larger surface-to-volume ratio, advantages of low reagent consumption, faster reaction kinetics, and more compact systems are evident in microfluidics. However, miniaturization of microfluidic chips and systems introduces challenges of stricter tolerances in designing and controlling them for interdisciplinary applications. Recent advances in artificial intelligence (AI) have brought i

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Sateesh, Jasti, Koushik Guha, Arindam Dutta, et al. "A comprehensive review on advancements in tissue engineering and microfluidics toward kidney-on-chip." Biomicrofluidics 16, no. 4 (2022): 041501. http://dx.doi.org/10.1063/5.0087852.

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This review provides a detailed literature survey on microfluidics and its road map toward kidney-on-chip technology. The whole review has been tailored with a clear description of crucial milestones in regenerative medicine, such as bioengineering, tissue engineering, microfluidics, microfluidic applications in biomedical engineering, capabilities of microfluidics in biomimetics, organ-on-chip, kidney-on-chip for disease modeling, drug toxicity, and implantable devices. This paper also presents future scope for research in the bio-microfluidics domain and biomimetics domain.

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Gyimah, Nafisat, Ott Scheler, Toomas Rang, and Tamas Pardy. "Can 3D Printing Bring Droplet Microfluidics to Every Lab?—A Systematic Review." Micromachines 12, no. 3 (2021): 339. http://dx.doi.org/10.3390/mi12030339.

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In recent years, additive manufacturing has steadily gained attention in both research and industry. Applications range from prototyping to small-scale production, with 3D printing offering reduced logistics overheads, better design flexibility and ease of use compared with traditional fabrication methods. In addition, printer and material costs have also decreased rapidly. These advantages make 3D printing attractive for application in microfluidic chip fabrication. However, 3D printing microfluidics is still a new area. Is the technology mature enough to print complex microchannel geometries

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Min, Lingli, Songyue Chen, Xinwen Xie, et al. "Development and application of bio-inspired microfluidics." International Journal of Modern Physics B 32, no. 18 (2018): 1840013. http://dx.doi.org/10.1142/s0217979218400131.

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Bio-inspired microfluidic systems can be obtained through multidisciplinary approaches by using bio-inspired structural and functional designs for the microfluidic devices. This review mainly focuses on the concept of bio-inspired microfluidics to improve the properties of microfluidic systems for breaking through the bottlenecks of the current microfluidic devices, such as anti-fouling, smart, and dynamic response inside the microchannels under different environments. In addition, here, we show the current research progress of bio-inspired microfluidic systems in applications related to anti-

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Teo, Adrian J. T., Siu-Kin Ng, Kaydeson Khoo, Sunny Hei Wong, and King Ho Holden Li. "Microfluidic Gastrointestinal Cell Culture Technologies—Improvements in the Past Decade." Biosensors 14, no. 9 (2024): 449. http://dx.doi.org/10.3390/bios14090449.

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Gastrointestinal cell culture technology has evolved in the past decade with the integration of microfluidic technologies, bringing advantages with greater selectivity and cost effectiveness. Herein, these technologies are sorted into three categories, namely the cell-culture insert devices, conventional microfluidic devices, and 3D-printed microfluidic devices. Each category is discussed in brief with improvements also discussed here. Introduction of different companies and applications derived from each are also provided to encourage uptake. Subsequently, future perspectives of integrating m

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Carvalho, Bruna G., Bruno T. Ceccato, Mariano Michelon, Sang W. Han, and Lucimara G. de la Torre. "Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application." Pharmaceutics 14, no. 1 (2022): 141. http://dx.doi.org/10.3390/pharmaceutics14010141.

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Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nano

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Shi, Jingyu, Yu Zhang, and Mo Yang. "Recent development of microfluidics-based platforms for respiratory virus detection." Biomicrofluidics 17, no. 2 (2023): 024104. http://dx.doi.org/10.1063/5.0135778.

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With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive assays are needed to expedite diagnosis and early intervention. Conventional methods for detection of respiratory viruses include cell culture-based assays, serological tests, nucleic acid detection (e.g., RT-PCR), and direct immunoassays. However, these traditional methods are often time-consuming, labor-intensive, and require laboratory facilities, which cannot meet the testing needs, especially during pandemics of res

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Zhu, Zhiyuan, Fan Zeng, Zhihua Pu, and Jiyu Fan. "Conversion Electrode and Drive Capacitance for Connecting Microfluidic Devices and Triboelectric Nanogenerator." Electronics 12, no. 3 (2023): 522. http://dx.doi.org/10.3390/electronics12030522.

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Microfluidics is a technique that uses channels of tiny sizes to process small amounts of fluid, which can be used in biochemical detection, information technology, and other fields. In the process of microfluidic development, there are many problems that need to be solved urgently. Many microfluidic systems require the support of external devices, which increases the construction cost, and the electronic interface technology is not mature. A triboelectric nanogenerator (TENG) can harvest mechanical energy and turn it into electrical energy. It has been greatly developed now and is widely used

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Babikian, Sarkis, Brian Soriano, G. P. Li, and Mark Bachman. "Laminate Materials for Microfluidic PCBs." International Symposium on Microelectronics 2012, no. 1 (2012): 000162–68. http://dx.doi.org/10.4071/isom-2012-ta54.

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The printed circuit board (PCB) is a very attractive platform to produce highly integrated highly functional microfluidic devices. We have investigated laminate materials and developed novel fabrication processes to realize low cost and scalable to manufacturing integrated microfluidics on PCBs. In this paper we describe our vision to integrate functional components with microfluidic channels. We also report on the use of Ethylene Vinyl Acetate (EVA) as a laminate for microfluidics. The material was characterized for microfluidic applications and compared with our previously reported laminates

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Evard, Hanno, Hans Priks, Indrek Saar, Heili Aavola, Tarmo Tamm, and Ivo Leito. "A New Direction in Microfluidics: Printed Porous Materials." Micromachines 12, no. 6 (2021): 671. http://dx.doi.org/10.3390/mi12060671.

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In this work, the feasibility of a novel direction for microfluidics is studied by demonstrating a set of new methods to fabricate microfluidic systems. Similarly to microfluidic paper-based analytical devices, porous materials are being used. However, alternative porous materials and different printing methods are used here to give the material the necessary pattern to act as a microfluidic system. In this work, microfluidic systems were produced by the following three separate methods: (1) by curing a porous monolithic polymer sheet into a necessary pattern with photolithography, (2) by scre

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Naher, Sumsun, Dylan Orpen, Dermot Brabazon, and Muhammad M. Morshed. "An Overview of Microfluidic Mixing Application." Advanced Materials Research 83-86 (December 2009): 931–39. http://dx.doi.org/10.4028/www.scientific.net/amr.83-86.931.

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Microfluidics is a technology where application span the biomedical field and beyond. Single cell analysis, tissue engineering, capillary electrophoresis, cancer detection, and immunoassays are just some of the applications within the medical field where microfluidics have excelled. The development of microfluidic technology has lead to novel research into fuel cells, ink jet printing, microreactors and electronic component cooling areas as diverse as food, pharmaceutics, cosmetics, medicine and biotechnology have benefited from these developments. Since laminar flow is prevailing at most flow

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Zhang, Jia Ming, Qinglei Ji, and Huiling Duan. "Three-Dimensional Printed Devices in Droplet Microfluidics." Micromachines 10, no. 11 (2019): 754. http://dx.doi.org/10.3390/mi10110754.

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Droplet microfluidics has become the most promising subcategory of microfluidics since it contributes numerous applications to diverse fields. However, fabrication of microfluidic devices for droplet formation, manipulation and applications is usually complicated and expensive. Three-dimensional printing (3DP) provides an exciting alternative to conventional techniques by simplifying the process and reducing the cost of fabrication. Complex and novel structures can be achieved via 3DP in a simple and rapid manner, enabling droplet microfluidics accessible to more extensive users. In this artic

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Deng, Jinan, Dandan Han, and Jun Yang. "Applications of Microfluidics in Liquid Crystal-Based Biosensors." Biosensors 11, no. 10 (2021): 385. http://dx.doi.org/10.3390/bios11100385.

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Liquid crystals (LCs) with stimuli-responsive configuration transition and optical anisotropic properties have attracted enormous interest in the development of simple and label-free biosensors. The combination of microfluidics and the LCs offers great advantages over traditional LC-based biosensors including small sample consumption, fast analysis and low cost. Moreover, microfluidic techniques provide a promising tool to fabricate uniform and reproducible LC-based sensing platforms. In this review, we emphasize the recent development of microfluidics in the fabrication and integration of LC-

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Mea, H., and J. Wan. "Microfluidics-enabled functional 3D printing." Biomicrofluidics 16, no. 2 (2022): 021501. http://dx.doi.org/10.1063/5.0083673.

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Microfluidic technology has established itself as a powerful tool to enable highly precise spatiotemporal control over fluid streams for mixing, separations, biochemical reactions, and material synthesis. 3D printing technologies such as extrusion-based printing, inkjet, and stereolithography share similar length scales and fundamentals of fluid handling with microfluidics. The advanced fluidic manipulation capabilities afforded by microfluidics can thus be potentially leveraged to enhance the performance of existing 3D printing technologies or even develop new approaches to additive manufactu

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Zeng, Jin, Hang Xu, Ze-Rui Song, et al. "High Frequency and Addressable Impedance Measurement System for On-Site Droplet Analysis in Digital Microfluidics." Electronics 13, no. 14 (2024): 2810. http://dx.doi.org/10.3390/electronics13142810.

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Digital microfluidics is a novel technique for manipulating discrete droplets with the advantages of programmability, small device size, low cost, and easy integration. The development of droplet sensing methods advances the automation control of digital microfluidics. Impedance measurement emerges as a promising technique for droplet localization and characterization due to its non-invasive nature, high sensitivity, simplicity, and cost-effectiveness. However, traditional impedance measurement approaches in digital microfluidics based on the high-voltage actuating signal are limited in sensin

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Lingadahalli Kotreshappa, Sreedevi, Chempi Gurudas Nayak, and Santhosh Krishnan Venkata. "A Review on the Role of Microflow Parameter Measurements for Microfluidics Applications." Systems 11, no. 3 (2023): 113. http://dx.doi.org/10.3390/systems11030113.

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Microfluidics has risen to a new zone of exploration because of its application in numerous fields. The integration of microfluidics and sensor technology bridges gaps in heat transfer areas, the medical field, and the chemical industry at the microscale flow level. This paper reviews the latest work conducted in microfluidics with the help of microflow parameter measurements in microfluidic applications, microflow sensor inventions, novel microflow pathway design, and an assessment of the keyway of fluid behavior in microchannels. The emphasis is on highlighting a significant part of recent r

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Salipante, Paul F. "Microfluidic techniques for mechanical measurements of biological samples." Biophysics Reviews 4, no. 1 (2023): 011303. http://dx.doi.org/10.1063/5.0130762.

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The use of microfluidics to make mechanical property measurements is increasingly common. Fabrication of microfluidic devices has enabled various types of flow control and sensor integration at micrometer length scales to interrogate biological materials. For rheological measurements of biofluids, the small length scales are well suited to reach high rates, and measurements can be made on droplet-sized samples. The control of flow fields, constrictions, and external fields can be used in microfluidics to make mechanical measurements of individual bioparticle properties, often at high sampling

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Juang, Yi-Je, and Yu-Jui Chiu. "Fabrication of Polymer Microfluidics: An Overview." Polymers 14, no. 10 (2022): 2028. http://dx.doi.org/10.3390/polym14102028.

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Microfluidic platform technology has presented a new strategy to detect and analyze analytes and biological entities thanks to its reduced dimensions, which results in lower reagent consumption, fast reaction, multiplex, simplified procedure, and high portability. In addition, various forces, such as hydrodynamic force, electrokinetic force, and acoustic force, become available to manipulate particles to be focused and aligned, sorted, trapped, patterned, etc. To fabricate microfluidic chips, silicon was the first to be used as a substrate material because its processing is highly correlated t

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Alhalaili, Badriyah, Ileana Nicoleta Popescu, Carmen Otilia Rusanescu, and Ruxandra Vidu. "Microfluidic Devices and Microfluidics-Integrated Electrochemical and Optical (Bio)Sensors for Pollution Analysis: A Review." Sustainability 14, no. 19 (2022): 12844. http://dx.doi.org/10.3390/su141912844.

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An overview of the recent research works and trends in the design and fabrication of microfluidic devices and microfluidics-integrated biosensors for pollution analysis and monitoring of environmental contaminants is presented in this paper. In alignment with the tendency in miniaturization and integration into “lab on a chip” devices to reduce the use of reagents, energy, and implicit processing costs, the most common and newest materials used in the fabrication of microfluidic devices and microfluidics-integrated sensors and biosensors, the advantages and disadvantages of materials, fabricat

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Kunjumon, Mekha, Libina Babu, and Aswathy Boss. "Microfluidics Relevant Approaches in Drug Delivery System Treatment of Cancer – A Review." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 09 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem37596.

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Microfluidics technology is a promising method for creating advanced drug delivery systems, particularly in cancer detection and treatment. These systems provide accurate, efficient, and user-friendly methods for cancer detection and treatment by examining small samples. Microfluidic devices can produce nanoparticles for medication administration and identify cancer-diagnostic variables from biological fluids. Due to their high sensitivity, high throughput, and low cost, microfluidics may be useful in cancer study. While not currently used in clinical settings, microfluidic systems are expecte

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Duan, Kai, Mohamad Orabi, Alexus Warchock, et al. "Monolithically 3D-Printed Microfluidics with Embedded µTesla Pump." Micromachines 14, no. 2 (2023): 237. http://dx.doi.org/10.3390/mi14020237.

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Microfluidics has earned a reputation for providing numerous transformative but disconnected devices and techniques. Active research seeks to address this challenge by integrating microfluidic components, including embedded miniature pumps. However, a significant portion of existing microfluidic integration relies on the time-consuming manual fabrication that introduces device variations. We put forward a framework for solving this disconnect by combining new pumping mechanics and 3D printing to demonstrate several novel, integrated and wirelessly driven microfluidics. First, we characterized

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Zhang, Peiran, Hunter Bachman, Adem Ozcelik, and Tony Jun Huang. "Acoustic Microfluidics." Annual Review of Analytical Chemistry 13, no. 1 (2020): 17–43. http://dx.doi.org/10.1146/annurev-anchem-090919-102205.

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Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we summarize the physical principles underlying acoustic microfluidics and review their applications, with particular emphasis on the manipulation of macromolecules, cells, particles, model organisms,

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Coelho, Beatriz J., Joana P. Neto, Bárbara Sieira, et al. "Hybrid Digital-Droplet Microfluidic Chip for Applications in Droplet Digital Nucleic Acid Amplification: Design, Fabrication and Characterization." Sensors 23, no. 10 (2023): 4927. http://dx.doi.org/10.3390/s23104927.

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Microfluidic-based platforms have become a hallmark for chemical and biological assays, empowering micro- and nano-reaction vessels. The fusion of microfluidic technologies (digital microfluidics, continuous-flow microfluidics, and droplet microfluidics, just to name a few) presents great potential for overcoming the inherent limitations of each approach, while also elevating their respective strengths. This work exploits the combination of digital microfluidics (DMF) and droplet microfluidics (DrMF) on a single substrate, where DMF enables droplet mixing and further acts as a controlled liqui

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Gorgannezhad, Lena, Helen Stratton, and Nam-Trung Nguyen. "Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology." Micromachines 10, no. 6 (2019): 408. http://dx.doi.org/10.3390/mi10060408.

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Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this research area has had a broad range of applications. Novel and innovative strategies for detection and identification of bacterial nucleic acids are important for practical applications. Microfluidics is an emerging technology that only requires small amounts of liquid samples. Microfluidic devices allow for rapid advances in microbiology, enabling access to methods of amplifying nucleic acid molecules and overcoming difficulties faced by conventional. In this review, we summarize the recent progre

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Luo, Dandan, Peng Wang, Huifei Lu, Xianhai Zeng, Hailiang Zhao, and Jiangqi Liu. "The application of microfluidic technology in allergen detection: A review." Medicine 104, no. 23 (2025): e42645. https://doi.org/10.1097/md.0000000000042645.

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The escalating prevalence of allergic diseases has intensified the need for rapid and precise allergen detection, prompting the exploration of microfluidic technology in this domain. This review delves into the utility of microfluidics in enhancing allergen detection, underscoring its high sensitivity, throughput, and miniaturization advantages. We survey the spectrum of microfluidic chip materials, from silicon wafers to paper-based substrates, and discuss various fabrication techniques. The integration of microfluidics with detection methods like enzyme-linked immunosorbent assay (ELISA), po

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Wang, Lingtian, Dajun Jiang, Qiyang Wang, Qing Wang, Haoran Hu, and Weitao Jia. "The Application of Microfluidic Techniques on Tissue Engineering in Orthopaedics." Current Pharmaceutical Design 24, no. 45 (2019): 5397–406. http://dx.doi.org/10.2174/1381612825666190301142833.

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Background: Tissue engineering (TE) is a promising solution for orthopaedic diseases such as bone or cartilage defects and bone metastasis. Cell culture in vitro and scaffold fabrication are two main parts of TE, but these two methods both have their own limitations. The static cell culture medium is unable to achieve multiple cell incubation or offer an optimal microenvironment for cells, while regularly arranged structures are unavailable in traditional cell-laden scaffolds, which results in low biocompatibility. To solve these problems, microfluidic techniques are combined with TE. By provi

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Giri, Kiran, and Chia-Wen Tsao. "Recent Advances in Thermoplastic Microfluidic Bonding." Micromachines 13, no. 3 (2022): 486. http://dx.doi.org/10.3390/mi13030486.

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Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechanical rigidity, organic solvent resistivity, acid/base resistivity, and low water absorbance make thermoplastics suitable for various microfluidic applications. However, bonding of thermoplastics has always been challenging because of a wide range of bonding methods and requirements. This review paper summarizes the current bonding processes being p

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Emde, Benedikt, Karsten Niehaus, and Lara Tickenbrock. "Evaluation of 3D-Printed Microfluidic Structures for Use in AML-Specific Biomarker Detection of PML::RARA." International Journal of Molecular Sciences 26, no. 2 (2025): 497. https://doi.org/10.3390/ijms26020497.

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An obstacle for many microfluidic developments is the fabrication of its structures, which is often complex, time-consuming, and expensive. Additive manufacturing can help to reduce these barriers. This study investigated whether the results of a microfluidic assay for the detection of the promyelocytic leukemia (PML)-retinoic acid receptor α (RARα) fusion protein (PML::RARA), and thus for the differential diagnosis of acute promyelocytic leukemia (APL), could be transferred from borosilicate glass microfluidic structures to additively manufactured fluidics. Digital light processing (DLP) and

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Männel, Max J., Elif Baysak, and Julian Thiele. "Fabrication of Microfluidic Devices for Emulsion Formation by Microstereolithography." Molecules 26, no. 9 (2021): 2817. http://dx.doi.org/10.3390/molecules26092817.

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Droplet microfluidics—the art and science of forming droplets—has been revolutionary for high-throughput screening, directed evolution, single-cell sequencing, and material design. However, traditional fabrication techniques for microfluidic devices suffer from several disadvantages, including multistep processing, expensive facilities, and limited three-dimensional (3D) design flexibility. High-resolution additive manufacturing—and in particular, projection micro-stereolithography (PµSL)—provides a promising path for overcoming these drawbacks. Similar to polydimethylsiloxane-based microfluid

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Zhang, Zhiwei, Yi Li, Jie Liang, Lei Zhang, and Jianhua Zhang. "P‐10.11: Digital Microfluidics Chip for Sweat Detection Based on Dielectric Wetting." SID Symposium Digest of Technical Papers 55, S1 (2024): 1276–78. http://dx.doi.org/10.1002/sdtp.17339.

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Digital microfluidics (DMF) is a technique for actively dispensing and manipulating discrete microdroplets on hydrophobic surfaces. DMF devices based on electrowetting on medium (EWOD) effect are widely used due to their advantages of fast response speed, simple system and high accuracy. Microfluidics is important for sweat sensing because it minimizes sweat pollution and evaporation of sweat on the skin. However, the current microfluidic channel has some problems, such as the old and new sweat is easy to mix in the channel, the self‐driving efficiency is too low, and the small sweat volume ca

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Vitorino, Rui, Sofia Guedes, João Pinto da Costa, and Václav Kašička. "Microfluidics for Peptidomics, Proteomics, and Cell Analysis." Nanomaterials 11, no. 5 (2021): 1118. http://dx.doi.org/10.3390/nano11051118.

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Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In p

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Chen, Yu-Shih, Chun-Hao Huang, Ping-Ching Pai, Jungmok Seo, and Kin Fong Lei. "A Review on Microfluidics-Based Impedance Biosensors." Biosensors 13, no. 1 (2023): 83. http://dx.doi.org/10.3390/bios13010083.

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Electrical impedance biosensors are powerful and continuously being developed for various biological sensing applications. In this line, the sensitivity of impedance biosensors embedded with microfluidic technologies, such as sheath flow focusing, dielectrophoretic focusing, and interdigitated electrode arrays, can still be greatly improved. In particular, reagent consumption reduction and analysis time-shortening features can highly increase the analytical capabilities of such biosensors. Moreover, the reliability and efficiency of analyses are benefited by microfluidics-enabled automation. T

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Zhang, Yueyue, Tingting Zheng, Li Wang, et al. "From passive to active sorting in microfluidics: A review." REVIEWS ON ADVANCED MATERIALS SCIENCE 60, no. 1 (2021): 313–24. http://dx.doi.org/10.1515/rams-2020-0044.

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Abstract Achieving high-efficiency sorting of microfluidics (such as cells, particles, droplets, etc.) has great significance in the fields of biology, chemistry, medical treatment, material synthesis, and drug development. This paper introduces the microfluidics sorting methods in recent years. The current research status and progress can be divided into the active sorting system and passive sorting system according to whether there is an external field. They can control the microfluidics by promoting more selective separation, so as to obtain higher resolution and selection rate. In this pap

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Abbasi Moud, Aref. "Cellulose through the Lens of Microfluidics: A Review." Applied Biosciences 1, no. 1 (2022): 1–37. http://dx.doi.org/10.3390/applbiosci1010001.

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Cellulose, a linear polysaccharide, is the most common and renewable biopolymer in nature. Because this natural polymer cannot be melted (heated) or dissolved (in typical organic solvents), making complicated structures from it necessitates specialized material processing design. In this review, we looked at the literature to see how cellulose in various shapes and forms has been utilized in conjunction with microfluidic chips, whether as a component of the chips, being processed by a chip, or providing characterization via chips. We utilized more than approximately 250 sources to compile this

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Varghese, Stefna, Dr Poonam Parashar, and Dr. Pragya. "Applications of Microfluidics in Biomedical and Pharmaceutical Fields-An Overview." International Journal of Preventive Medicine and Health 5, no. 4 (2025): 5–10. https://doi.org/10.54105/ijpmh.d1066.05040525.

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The precise manipulation of fluids at the microscale level within minuscule channels measuring tens to hundreds of micrometres is the subject of the multifaceted field of microfluidics. This technology has transformed the pharmaceutical industry by enabling miniaturised, highthroughput, and economical drug discovery, formulation, and delivery solutions. Creating sophisticated drug delivery systems like nanoparticles and liposomes has become far simpler because this method can precisely control fluid dynamics, enabling faster reaction kinetics and better drug encapsulation. Beyond drug formulat

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Dr., Pragya. "Applications of Microfluidics in Biomedical and Pharmaceutical Fields -An Overview." International Journal of Preventive Medicine and Health (IJPMH) 5, no. 4 (2025): 5–10. https://doi.org/10.54105/ijpmh.D1066.05040525/.

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<strong>Abstract: </strong>The precise manipulation of fluids at the microscale level within minuscule channels measuring tens to hundreds of micrometres is the subject of the multifaceted field of microfluidics. This technology has transformed the pharmaceutical industry by enabling miniaturised, highthroughput, and economical drug discovery, formulation, and delivery solutions. Creating sophisticated drug delivery systems like nanoparticles and liposomes has become far simpler because this method can precisely control fluid dynamics, enabling faster reaction kinetics and better drug encapsul

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Hsu, Jin-Chen. "Enhanced Micromixing Using Surface Acoustic Wave Devices: Fundamentals, Designs, and Applications." Micromachines 16, no. 6 (2025): 619. https://doi.org/10.3390/mi16060619.

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Microfluidics-based mixing methods have attracted increasing attention due to their great potential in bio-related and material science fields. The combination of acoustics and microfluidics, called acoustofluidics, has been shown to be a promising tool for precise manipulation of microfluids and micro-objects. In general, achieving robust mixing performance in an efficient and simple manner is crucial for microfluidics-based on-chip devices. When surface acoustic waves (SAWs) are introduced into microfluidic devices, the acoustic field can drive highly controllable acoustic streaming flows th

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Schwemmer, F., S. Zehnle, D. Mark, F. von Stetten, R. Zengerle, and N. Paust. "A microfluidic timer for timed valving and pumping in centrifugal microfluidics." Lab on a Chip 15, no. 6 (2015): 1545–53. http://dx.doi.org/10.1039/c4lc01269k.

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Jeyhani, Morteza, Maryam Navi, Katherine W. Y. Chan, Jennifer Kieda, and Scott S. H. Tsai. "Water-in-water droplet microfluidics: A design manual." Biomicrofluidics 16, no. 6 (2022): 061503. http://dx.doi.org/10.1063/5.0119316.

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Droplet microfluidics is utilized in a wide range of applications in biomedicine and biology. Applications include rapid biochemical analysis, materials generation, biochemical assays, and point-of-care medicine. The integration of aqueous two-phase systems (ATPSs) into droplet microfluidic platforms has potential utility in oil-free biological and biomedical applications, namely, reducing cytotoxicity and preserving the native form and function of costly biomolecular reagents. In this review, we present a design manual for the chemist, biologist, and engineer to design experiments in the cont

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