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Journal articles on the topic 'Microsponge'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kaur, Manpreet, Ritu Rani, Ajeet Pal Singh, and Amar Pal Singh. "Microsponge: A Review." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 294–97. http://dx.doi.org/10.22270/jddt.v14i6.6620.

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Microsponge are little spherical molecules with a broad porous surface that resemble sponges. The use of microsponges is a unique medication delivery method that has several benefits. For a range of illnesses, the Microsponges drug delivery system is utilized to improve the effectiveness of oral, parenteral, or topical medicine administration. A novel approach of managing drug release and administering medication to specific locations is microsponge technology. The efficient and novel way that microsponge medicine administration advances properties, boosts item stability, and improves security

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2

Tyagi Gajendra, Choudhary Suresh, and Kalra Naresh. "Formulation of microsponges of anti-fungal drugs and their pharmacokinetic and in vitro analysis." Tropical Journal of Pharmaceutical and Life Sciences 11, no. 2 (2024): 24–44. http://dx.doi.org/10.61280/tjpls.v11i2.158.

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Microsponges are uniform, spherical, porous polymeric microspheres having myriad interconnected voids of particle size range 5-300 μm. These microsponges have the capacity to entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens and anti-infective, etc. and then release them onto the skin over a time in response to a trigger. Microsponge Delivery System (MDS) can be used to resolve the problem associated with these conventional approaches. The drug entrapped microsponges can be incorporated into a formulated product, such as a gel, cream, liquid o

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3

Shukla, Mukesh Kumar, and Abadhesh Kumar Niranjan. "Floating Microsponge: An Emerging Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 264–69. http://dx.doi.org/10.22270/jddt.v12i4-s.5553.

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Floating microsponges are a method to extend gastric residence time, there with the aid of using concentrated on site-responsive medicament liberate withinside the top GIT for locally or systemic effect. Gastro retentive dosage forms (GRDFs) are getting utilized from a totally long term to enhance treatment with numerous main medications. Floating microsponge significantly enhances the therapy of stomach with the aid of using liberating the medication locally and for that reason used for medication selecting at specific organ. This may be sustained over an extended period of time. Floating dru

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4

Kumar, Rajat, and Dr Mahesh Kumar Kataria. "A Review on Recent Application of Novel Approach Microspounge." Research and Analysis Journal 5, no. 1 (2022): 01–06. http://dx.doi.org/10.18535/raj.v5i1.276.

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In the field of drug delivery system, there are numerous new formulation techniques. Microsponge are one of the most recent novel technique which are gaining popularity now days due to their use of controlled release and targeted drug delivery system. Microsponge technology offers entrapment of ingredient and is believed to contribute towards reduced side effect, improved stability, increase elegance and enhanced formulation flexibility. In addition, microsponges are non-irritating, non-mutagenic, non-allergenic and non-toxic. One of the best features of microsponge is its self-sterilizing abi

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5

Alatraqchi, Faten Ibraheem, and Fatima J. AL Gawhri. "Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 1 (2019): 75–90. http://dx.doi.org/10.31351/vol28iss1pp75-90.

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The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release

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6

D. Gidde, Nikita, Komal A. Karande, Snehal S. Jadhav, Ruksar S. Mistry, Pratiksha A. Mhetre, and Sourabh D. Joshi. "Microsponge : An Overview." Journal of University of Shanghai for Science and Technology 23, no. 11 (2021): 671–82. http://dx.doi.org/10.51201/jusst/21/11949.

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Microsponges are a revolutionary way of medication administration that has a number of advantages. The Microsponges drug delivery system is used to increase the performance of medications that are delivered orally, parenterally, or topically in a variety of conditions. Microsponge is a new technology for controlling medication release and delivering drugs to precise targets. Microsponge technology has been used in topical medicinal solutions to allow for regulated active drug release into the skin, lowering systemic exposure and reducing local cutaneous reactions to active pharmaceuticals. Thi

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7

Rani, Pooja, Sonu Goyat, Sourav Phalswal, et al. "Development of Propyl Paraben-Loaded Microsponge for Enhanced Preservation in Skin Creams." Journal of Neonatal Surgery 14, no. 32S (2025): 1541–51. https://doi.org/10.63682/jns.v14i32s.7594.

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This study emphasizes developing a microsponge-based delivery system for propylparaben, a broadly used preservative in skin creams. The microsponge technology was employed to control the release of propylparaben, thereby reducing the risk of skin irritation and other adverse effects. The optimized microsponge formulation was incorporated into a cold cream and evaluated for its physical properties, in vitro release profile, and preservative efficacy. The results reveal that the microsponge-loaded propyl paraben provided sustained release and improved preservative activity, ultimately extending

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8

A. Nief, Roaa, and Ahmed A. Hussein. "Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 62–74. http://dx.doi.org/10.31351/vol23iss2pp62-74.

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The aim of present study was to develop gel formulation of microsponges of poorly soluble drug meloxicam (MLX) in order to enhance the release and dissolution of MLX which is the limitation for preparation in topical forms. Also skin delivery is an alternative administration for MLX that can minimize gastrointestinal (GI) side effects and improve patient compliance. The microsponges of MLX were prepared by quasi-emulsion solvent diffusion method. The effects of drug:polymer ratio, stirring time and Eudragit polymer type on the physical characteristics of microsponges were investigated and char

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9

Nishal, Suchitra, Parmita Phaugat, Renu Tushir, and Manish Dhall. "A CONCISE LITERATURE REVIEW ON STUDY OF MICROSPONGES FROM ANCIENT TO RECENT." Indian Drugs 59, no. 09 (2022): 7–15. http://dx.doi.org/10.53879/id.59.09.12328.

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Polymeric microspheres enclosing an extremely porous surface are termed as microsponges. Microsponges are drug loaded microporous beads having 10-25 micron diameter. These may augment stability, ease side effects and amend drug release. Microsponge systems have capability to capture ample drug substances and are then formulated into various products like gel, cream, liquid or powder. Several research studies corroborated that microsponge entities possess non-irritant, non-mutant, non-allergic and non-toxicity features. Suitable analytical techniques for characterization of microsponges can be

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10

Dev, Asish, and Mahadev khorate. "An Innovative Strategy, Current Status and Future Prospects for Microsponge Technology." Journal of Molecular Pharmaceuticals and Regulatory Affairs 4, no. 1 (2022): 8–24. http://dx.doi.org/10.46610/jmpra.2022.v04i01.002.

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In the rapidly evolving field of novel drug delivery technology, microsponges are at the forefront Scientist have become increasingly intrigued by microsponge drug delivery technology because it holds great promise for achieving the goal of controlled and specific drug delivery, and it has thus captured the interest of many researchers. The microsponge delivery system, an innovative technology for controlled drug delivery, is a polymeric delivery system that contains porous microsphere range in size from 5 to 300μm. Microsponge structure is not irritating, non-mutagenic, non- allergic or toxic

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11

Naga Jyothi, K., P. Dinesh Kumar, P. Arshad, M. Karthik, and T. Panneerselvam. "Microsponges: A Promising Novel Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 188–94. http://dx.doi.org/10.22270/jddt.v9i5-s.3649.

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Microsponge is recent novel technique for control release and target specific drug delivery system. More and more developments in drug delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponges are polymeric delivery system containing porous microspheres having a size range from 5 to 300µm. Microsponge Delivery System (MDS) is a unique technology for controlled drug delivery. This review article mainly deals with Microsponge drug delivery along with its method of preparation, characterization, advantages and release mechanism of MDS. Micr

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12

Hans, Mansi, Jagdeep Singh Dua, D. N. Prasad, Diksha Sharma, and ,. Monika. "A Review on Microsponge Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1032–40. http://dx.doi.org/10.22270/jddt.v9i3-s.2938.

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Microsponge is recent novel technique for control release and target specific drug delivery system. Microsponge technology has been introduced in pharmaceutical industry to provide the controlled release of active drug ingredient for the application into the skin in order to decrease systemic exposure and reduce local cutaneous reactions to active drugs. Microsponges comprises of microporous beads, typically 10-25 microns in diameter, loaded with active agent. The microsponge releases its active ingredient on a time mode, when applied to the skin, and also in response to other stimuli that are

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Akshata, V. Raut* Nakul Kathar Ganjanan Sanap. "Microsponges: The Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 328–41. https://doi.org/10.5281/zenodo.10523750.

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Microsponge technology has been developed for topical drug products in order to promote controlled release of the drug's active ingredient into the skin, thereby reducing systemic exposure and minimizing local cutaneous reactions to active drugs. Microsponge is made up of macroporous beads that are normally 10-25 micron in diameter and loaded with an active agent. When applied to the skin, the microsponge releases its active ingredients on a timer as well as in response to other signals. Microsponge drug delivery technology holds great promise for achieving the goal of controlled and site-spec

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14

Bansode, Ashwini S., Vaishnavi B. Kute, Komal S. Vethekar, et al. "Formulation, development and evaluation of Microsponge loaded Topical Gel of Nystatin." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 451–61. http://dx.doi.org/10.22270/jddt.v9i2-s.2567.

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Nystatin containing microsponge as active constituent (API) in different formulations by changing the proportions of drug (Nystatin), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The physical characterization showed that microsponge formulation coded by P6 showed a better loading efficiency and production yield. This microsponge for

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15

Hans, Mansi, Jagdeep Singh Dua, D. N. Prasad, ,. Monika, and Diksha Sharma. "Formulation and Evaluation of Fluconazole Microsponge using Eudragit L 100 by Quasi Emulsion Solvent Diffusion Method." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 366–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2855.

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The aim of the present study is to formulate and evaluate the fluconazole microsponge by using Eudragit L 100. Microsponge was made because they provide controlled as well as target specific release of the drug. Thus study the effect of stirring rate on the formation of microsponge. Microsponge containing Fluconazole were prepared by quasi-emulsion solvent diffusion method at different stirring rate i.e 500, 800, 1000, 1200 and 1500 rpm. Particle size of prepared microsponge was observed in the range of 76.2 to 32.5μm. Scanning electron microscopy revealed the porous, spherical nature of the m

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16

Gunasheela S, V. Chandrakala, and S. Srinivasan. "Microsponge: An adaptable topical drug delivery system." World Journal of Advanced Research and Reviews 15, no. 1 (2022): 396–411. http://dx.doi.org/10.30574/wjarr.2022.15.1.0694.

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Microsponge a drug delivery system, possesses the versatility to load a wide range of active ingredients due large surface area. it facilitates controlled release of active ingredients and reduces systemic exposure and adverse effect. microsponges are polymeric sponges that consist of interconnecting voids with a flexible structure with a porous surface. Microsponge delivery techniques provides extended product stability, enhanced safety, enhanced formulation flexibility, product efficacy and aesthetic appeal with reduced adverse effects. It is regarded as safe, due to less bacterial contamina

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17

Yadav, Vishal, Prakash Jadhav, Shailaja Dombe, Anjali Bodhe, and Pranali Salunkhe. "FORMULATION AND EVALUATION OF MICROSPONGE GEL FOR TOPICAL DELIVERY OF ANTIFUNGAL DRUG." International Journal of Applied Pharmaceutics 9, no. 4 (2017): 30. http://dx.doi.org/10.22159/ijap.2017v9i4.17760.

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Objective: The purpose of present study aims to design novel drug delivery system containing oxiconazole nitrate microsponges and to prepare microsponge gel. Oxiconazole nitrate is an antifungal drug used in the treatment of fungal infection having a poor aqueous solubility, side effects and adverse reactions. The microsponge delivery system is unique technology for controlled release of active agents. Methods: The microsponges were prepared by quasi-emulsion solvent diffusion method by using polymer eudragit S-100 and eudragit L-100. All the formulated microsponges were subjected for various

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18

Faten Q. Ibraheem and Anmar A. Abdelrazzaq. "Studying the effect of variables on baclofen floating microsponge." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 1300–1306. http://dx.doi.org/10.26452/ijrps.v10i3.1467.

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The aim of the present work was to develop a microsponge delivery system of baclofen to control its release and thereby reducing dosing frequency and enhancing patient compliance. The microsponge was produced by oil in oil emulsion solvent diffusion method. The effects of drug/polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated. The prepared microsponges was characterized for production yield (PY), loading efficiency (LD), particle size, surface morphology, and in vitro drug release. The results showed that the microsponge

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19

Gunasheela, S., Chandrakala V., and Srinivasan S. "Microsponge: An adaptable topical drug delivery system." World Journal of Advanced Research and Reviews 15, no. 1 (2022): 396–411. https://doi.org/10.5281/zenodo.7743970.

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Microsponge a drug delivery system, possesses the versatility to load a wide range of active ingredients due large surface area. it facilitates controlled release of active ingredients and reduces systemic exposure and adverse effect. microsponges are polymeric sponges that consist of interconnecting voids with a flexible structure with a porous surface. Microsponge delivery techniques provides extended product stability, enhanced safety, enhanced formulation flexibility, product efficacy and aesthetic appeal with reduced adverse effects. It is regarded as safe, due to less bacterial contamina

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20

Pawar, Anil Raosaheb, Nikhil Arun Shete, Priyanka Vitthal Jadhav, Vinayak Kashinath Deshmukh, and Jaswandi Sameer Mehetre. "Enhancement of Aqueous Solubility, Dissolution Profile, and Oral Bioavailability of Pentoxifylline by Microsponges." Pharmaceutical Fronts 03, no. 04 (2021): e200-e207. http://dx.doi.org/10.1055/s-0041-1740242.

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Microsponge, a novel drug delivery system, is designed to deliver a pharmaceutically active ingredient efficiently at the minimum dose. Microsponge plays an important role in enhancing drug stability, reducing side effects, and modifying drug release profiles. It is mostly used for transdermal delivery. Recent studies also explored their use for oral administration. This study aimed to explore the potential use of the microsponge technique in improving the aqueous solubility and dissolution profile of pentoxifylline (PTX). In this study, microsponges were prepared by a quasi-emulsion solvent d

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21

Darekar, Avinash, Pooja Pawar, and Ravindranath B. Saudagar. "A Review on Microsponge as Emerging Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 793–801. http://dx.doi.org/10.22270/jddt.v9i3-s.2828.

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A microsponge delivery system will entrap a wide variety of active pharmaceutical ingredients and then release them onto the skin over a time and additionally in response to different stimuli including rubbing, moisture, pH, friction, or ambient skin temperature. It can also be used for controlled oral delivery of drugs using water-soluble, water-insoluble and bio-erodible polymers. The primary aim of any drug delivery system is to provide a therapeutic quantity of drug to the suitable site in the body, to punctually achieve and retain the desired drug concentration. The elemental application

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22

Ambika, Ganesh Subash Chandran M.P* Aparna P. Jaghatha T. Rajesh R. S. "MICROSPONGE - A NOVEL DRUG DELIVERY SYSTEM: AN OVERVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4823–30. https://doi.org/10.5281/zenodo.1283408.

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<em>Microsponge is recent novel technique for control release and target specific drug delivery system. Therefore many scientist or researcher attracted towards the microsponge drug delivery system. Also Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. </em><em>Microsponges are porous micr

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23

VISHWAKARMA, PRAMILA, and Ramraj Choudhary. "Microsponges: A Novel Strategy to Control the Delivery Rate of Active Agents with Reduced Skin Irritancy." Journal of Drug Delivery and Therapeutics 9, no. 6-s (2019): 238–47. http://dx.doi.org/10.22270/jddt.v9i6-s.3757.

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Microsponges are particulate system which is composed by porous polymeric material. As compare to Conventional topical formulations, microsponge provide controlled release of the drug in the epidermis, it is to ensure that the drug is mainly localized and does not unduly entering the systemic circulation, it is a new area of research. The active ingredient needs to maximize the time to stay on the skin, while reducing transdermal penetration. Apart from this, there is a problem of unethical vehicles that can be viscous sticky deformation and skin irritation. One of the biggest challenges of no

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24

Shinde, Jitendra, Rakesh Patel, and Shweta Shriwas. "Formulation and Evaluation of Microsponge Gel for Topical Delivery of Antifungal Drug." International Journal of Membrane Science and Technology 10, no. 2 (2023): 2526–37. http://dx.doi.org/10.15379/ijmst.v10i2.2904.

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The quasi emulsion solvent diffusion technique was used to create the clotrimazole microsponges, which were eventually recognized as an efficient carrier for the topical delivery of the medicine. The characteristics of the created system were significantly affected by the drug:polymer ratio. It was discovered that microsponges made for prolonged release formulation were effective, and clotrimazole microsponges with gel produced results that were equivalent. Microsponge gel compositions that were prepared beforehand showed regulated medication release. It has been shown that microsponges can tr

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25

Iqra, Shaikh Chainesh Shah Umesh Upadhyay. "Microsponges: A Novel Drug Delivery For Dermatological Application." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 699–710. https://doi.org/10.5281/zenodo.13926066.

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A microsponge's delivery system is a highly cross-linked, porous, polymeric microsphere system composed of porous microspheres capable of entrapping and releasing chemicals into the skin over time. This delivery system offers extended release, lower discomfort, better tolerance, and improved thermal, physical, and chemical stability. Microsponges are created using a variety of processes, such as suspension polymerization in a liquid-liquid system and emulsion systems. Microsponges can trap a variety of medications and can be utilized in cream, powder, gel, or lotion formulations. The delivery

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26

Saboo, Shweta, and Yogesh Bhise. "Microsponge: An Innovative and Novel Strategy for Drug Delivery System." Der Pharma Chemica 16, no. 1 (2024): 13. https://doi.org/10.4172/0975-413X.16.1.211-223.

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The microsponge approach has become a highly competitive and rapidly evolving technology. They are porous, highly cross-linked, polymeric microspheres that can be efficiently incorporated into topical drug delivery systems for the purpose of release and retention of dosage form on the skin over a long period of time. Furthermore, they may modify drug release, enhance stability, improve patient compliance and reduce side effects. microsponge systems are non-toxic, non-irritating, non-mutagenic and non-allergenic. In general, there are multiple methods used to manufacture microsponges, such as t

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Kshatriya, Pravin Jamnadas, Jitendra V. Shinde, and Rajashree S. Chavan. "As Review on Microsponge Gel as Topical Drug Delivery System." Journal of Drug Delivery and Therapeutics 10, no. 6-s (2020): 125–33. http://dx.doi.org/10.22270/jddt.v10i6-s.4455.

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Microsponges are drug delivery systems composed of porous microspheres. They are little sponge – like spherical particles with an outside surface porous surface. Moreover, they will enhance stability, scale back aspect effect and modify drug unharness favourably. Microsponge technology has several favorable characteristics that make it a flexible drug delivery vehicle. Microsponge system square measure supported microscopic, chemical compound based mostly microspheres that may suspend or entrap a good type of substances, and might may be incorporated into a developed product like a gel, cream,

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Adheena Jeby, Adheena Jeby, Ganesh N. S. Ganesh N S, Adlin Jino Nesalin Adlin Jino Nesalin, and Vineeth Chandy. "Unlocking the potential of microsponges: A versatile andfuturistic approach to oral drug delivery." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1059–68. https://doi.org/10.35629/4494-100110591068.

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Oral administration is widely regarded as the most practical and commonly used method for delivering medications. However, drugs with short half-lives and rapid gastrointestinal absorption are swiftly cleared from the bloodstream, necessitating frequent dosing. To address these challenges, oral controlled-release formulations have been developed. Among the innovative approaches in drug delivery systems, the Microsponge Delivery System (MDS) has gained significant attention.MDS consists of highly cross-linked, porous polymeric microspheres capable of entrapping a wide range of active compounds.

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Pawar, Atmaram P., Aditya P. Gholap, Ashwin B. Kuchekar, C. Bothiraja, and Ashwin J. Mali. "Formulation and Evaluation of Optimized Oxybenzone Microsponge Gel for Topical Delivery." Journal of Drug Delivery 2015 (February 18, 2015): 1–9. http://dx.doi.org/10.1155/2015/261068.

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Background. Oxybenzone, a broad spectrum sunscreen agent widely used in the form of lotion and cream, has been reported to cause skin irritation, dermatitis, and systemic absorption. Aim. The objective of the present study was to formulate oxybenzone loaded microsponge gel for enhanced sun protection factor with reduced toxicity. Material and Method. Microsponge for topical delivery of oxybenzone was successfully prepared by quasiemulsion solvent diffusion method. The effects of ethyl cellulose and dichloromethane were optimized by the 32 factorial design. The optimized microsponges were dispe

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Shinde, Jitendra, Rakesh Patel, and Shweta Shriwas. "Formulation and Evaluation of Topical Microsponge Based Gel of Clotrimazole." International Journal of Membrane Science and Technology 10, no. 2 (2023): 2538–48. http://dx.doi.org/10.15379/ijmst.v10i2.2905.

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The study's overarching goal is to develop a novel medication delivery method based on microsponge gel containing clotrimazole. Clotrimazole is poorly absorbed from the gastrointestinal tract (GIT), has a short half-life of only 2 h, & is metabolized into inert molecules by the liver. Therefore, clotrimazole's drug delivery method must be modified for topical application. Microsponge delivery is a novel approach to sustained drug release. Microsponges were made with a polymer solution of Eudragit RS 100 in dichloromethane (DCM) and ethanol (1:1) using a quasi-emulsion solvent diffusion tec

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Sakshi, Trivedi*, Verma Shubham, and Singh Sobhna. "FORMULATION & EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM FOR THE MANAGEMENT OF PAIN." World Journal of Pharmaceutical Science and Research 3, no. 4 (2024): 83–99. https://doi.org/10.5281/zenodo.13150564.

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Microsponges are unique dermatological delivery techniques that can entrap actives 3 times their weight. The microsponge drug delivery system (MDS) releases its active ingredient on time and in reaction to rubbing, temperature, and pH when given by topical route. The particles or surfaces of microsponges include several active components. Each non-collapsible microsphere has many interconnected gaps to absorb material like a sponge. Porous outer surfaces govern material flow into and out of the sphere. Nimesulide is known as "non-steroidal anti-inflammatory drug. "As an analgesic and antipyret

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Kothai, S., and R. Umamaheswari. "Fabrication and Characterisation of Honey Loaded Microsponges." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 18–23. http://dx.doi.org/10.22270/jddt.v9i4.3125.

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Ethylcellulose based microsponges loaded with honey were synthesized by Quasi-Emulsion solvent method. The honey loaded microsponges were characterised by Particle size distribution Analyser and High Resolution Scanning Electron Microscopy. The percentage drug content and Entrapment Efficiency of the loaded microsponges were determined. The antimicrobial and antioxidant activity of microsponges were evaluated. Keywords: Microsponge, Honey, antimicrobial, antioxidant.

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Mohan, Dinesh, and Vangadari Rama Mohan Gupta. "Microsponge based drug delivery system of voriconazole for fungal infection: formulation development and In-vitro evaluation." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 369–78. http://dx.doi.org/10.22270/jddt.v9i3.2840.

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The plan behind the present research work was to develop a microsponge based dosage form for modified delivery of voriconazole prepared by quasi-emulsion solvent diffusion method using polymer Ethylcellulose with two factors drug-polymer ratios and surfactant concentration, these two factors influences micro particles and physical properties. The characterization techniques followed for the formed microsponges were DSC, FT-IR, SEM and particle size analysis, along with morphology, drug loading, in-vitro drug release data. DSC and FT-IR data discloses that there were no chemical interactions be

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Das, Arnab, Prithviraj Chakraborty, Bunu Khatiwara, et al. "Herbal microsponge incorporated sunscreen gel: A novel strategy." Biomedicine 42, no. 5 (2022): 844–50. http://dx.doi.org/10.51248/.v42i5.2016.

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Different dermatological disorders have different effects on the lives of patients. Recently microsponge formulations have been used to treat several dermatological complications. Microsponges are basically tiny sponge like spherical particles with porous surface having valuable and attractive effect on topical delivery. The side effect of the used drug can be reduced, bioavailability can be increased, and the drug release can be modified. Microsponges can be used in different bases like gel, lotion, ointment and even in powder form. Microsponges used in sunscreen gel are now very popular. Exc

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Jyoti, Jyoti, and Sandeep Kumar. "INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 28–34. http://dx.doi.org/10.22270/jddt.v8i5.1885.

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Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is poly

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Girish, Bildani* Dr. Nalini Kurup Sakshi Ardeja. "Exploring Microsponge Technology: Applications Beyond Topical Drug Delivery." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2181–94. https://doi.org/10.5281/zenodo.14487858.

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An ultra-innovative drug delivery method called Microsponge has been developed for oral or topical use. Entrapped medicinal compounds are shielded from physical and environmental deterioration by microsponges, which are porous microspheres composed of polymer and biologically inert. Microsponge sizes range from 5 to 300 μm in diameter. Microsponge delivery systems (MDS) have been the subject of several recent developments for the controlled release of medications onto the epidermis with the guarantee that the drug stays mostly localized and does not significantly enter the systemic circulat

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Anjali, Bhansali Dr. A. Chandewar Dr. Madhuri Channawar Ashwini warnkar Anisha kohale. "Design And Chacterization of Novel Topical Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2915–25. https://doi.org/10.5281/zenodo.15450341.

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The present study focuses on the design and characterization of a novel topical drug delivery system incorporating Vitex negundo extract through microsponge technology followed by gel formulation. Vitex negundo, known for its potent anti-inflammatory and antimicrobial properties, and microsponges via the quasi-emulsion solvent diffusion technique, employing ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizer. The prepared microsponges were characterized for particle size, surface morphology, entrapment efficiency, and thermal stability using techniques such as, scanning elec

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Anju, Tomar* Dr. Narendra Mandoria Kamlesh Dashora Aashish Singh. "Microsponge: A Stable Microscopic Polymeric Delivery System." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 210–23. https://doi.org/10.5281/zenodo.14800431.

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Microsponge is polymeric delivery system and a drug carrier which have tiny microscopic structure with a larger porous surface. These are micro-sized particle with average diameter of 5-30 micron. The pores of a microsponge are used for entrapment of drug.  These are newer technologies which have been used to control the release of medicament from formulation and also it precises the drug in targeted delivery. Microsponges have several advantages like improved stability, extended release, improved bioavailability and précised drug targeting makes it a better carrier for drug than t

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Kamble, Srushti, Gangotri Yadav, and Ashish Jain. "Formulation and Evaluation of Terbinafine Hydro-chloride Loaded Microsponges Gel." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 6 (2023): 7038–48. http://dx.doi.org/10.37285/ijpsn.2023.16.6.3.

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Background: Microsponges are porous, polymeric microspheres employed for sustained topical treatment. They may modify the release pattern, lessen adverse effects, and improve stability. Terbinafine HCL is a fungicidal allylamine derivative with a wide range of antifungal activity. It is used to treat various skin disorders like ringworm, athlete’s foot, and jock itch. Objective: The aim of the current study focuses on the development of terbinafine HCL microsponges that will release the drug in a sustained pattern to prevent side effects and then put those microsponges into a gel. Method: The

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Hussien, Ahmed Abbas. "Preparation and Evaluation of Oral Microsponge Drug Delivery System of Ketoconazole." Al Mustansiriyah Journal of Pharmaceutical Sciences 14, no. 1 (2014): 1–8. http://dx.doi.org/10.32947/ajps.v14i1.119.

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In oral applications, the microsponge system has been shown to increase the rate of solubilization of poorly water-soluble drugs by entrapping such drugs in the microsponge system's pores.Because these pores are very small, the drug is in effect reduced tomicroscopic particles and increased surface area thus greatly increases the rate ofsolubilization.This investigation was done to increase solubility and then bioavialibility of poorly soluble ketoconazole (BCS class II drug) by preparing it as microsponges by quasi emulsionsolvent technique using different types of Eudragits as Eudragit E 100

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K, Vanitha, Navya Y, and Shastry Sheetal. "A Review on Microsponge Drug Delivery System of Pharmaceuticals." Journal of Pharmacological Research and Development (e-ISSN- 2582-0117) 2, no. 1 (2019): 1–12. https://doi.org/10.5281/zenodo.3402085.

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<em>Microsponges are polymeric microsphere delivery systems. They are small sponge-like spherical particles which have a large porous surface. </em><em>Porous microspheres with a size range between 5 and 300 microns depending on the degree of smoothness or the feeling necessary for the final formulations.</em><em> They may also improve stability, reduce side effects, and favorably Change drug release. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle.</em> <em>Microsponge systems are based on microscopic, polymer-based microspheres that

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Anju, Tomar1* Dr. Narendra Mandoria2 Kamlesh Dashora3 Dr. Praveen Khirwadkar4 Aashish Singh5. "Formulation And Evaluation of Dexketoprofen Trometamol Loaded Microsponge Gel." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 66–77. https://doi.org/10.5281/zenodo.14956312.

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Objective: The research work aims to demonstrate the potential of this microsponge gel as an effective treatment for severe acute pain with improved drug delivery and therapeutic outcomes. The research work involves the formulation and characterization of a Dexketoprofen Trometamol loaded microsponge gel for the severe acute pain. Microsponges are introduced as a promising drug delivery system due to their ability to provide sustained drug release and improved skin permeation with increased stability and its use in a microsponge gel formulation is hypothesized to improve its efficacy. Method:

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Ingale, Dipit Jagannath, N. H. Aloorkar, A. S. KulkarnI, and R. A. Patil Patil. "Microsponges as Innovative Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 1 (2012): 1597–606. http://dx.doi.org/10.37285/ijpsn.2012.5.1.2.

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Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique ability for entrapping active pharmaceutical ingredients. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by scientists. Micro

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Jayasawal, Pratima, N. G. Raghavendra Rao, and Vikas Jakhmola. "Microsponge as Novel Drug Delivery System: A Review." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 21–29. http://dx.doi.org/10.35652/igjps.2022.12002.

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During the last few decades, pharmaceutical industry gave more importance to the controlled release of dosage forms like solid formulation, semi solid formulation, and topicalpreparation dueto efficacy and patient compliance. Normal topical preparations have some disadvantages like unpleasant odour, greasiness, and skin irritation reported in study cases. Also many topicalpreparations fail to reach the systemic circulation in sufficient amounts in few cases. This problem is achieved by the present formulation as microsponge in the areas of research. MDS is amicroscopic sphere capable of absorb

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Shreya, Parihar* Nazneen Dubey Bharti Choudhary Shubhangi Nema. "A Review -Microsponges For The Treatment Of Acne Vulgaris." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 480–96. https://doi.org/10.5281/zenodo.13910667.

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Acne vulgaris is a common dermatological condition that affects a significant portion of the population, particularly adolescents and young adults. The need for effective topical treatments has led to the exploration of novel drug delivery systems. This study focuses on the formulation and characterization of nadifloxacin-loaded microsponge systems aimed at enhancing the therapeutic efficacy and skin penetration of the drug. Nadifloxacin, a potent topical antibiotic, is known for its effectiveness against acne-causing bacteria but is limited by its poor skin permeation and stability. Microspon

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Shreya, Parihar* Nazneen Dubey Bharti Choudhary Shubhangi Nema. "Formulation And Characterization Of Nadifloxacin Loaded Microsponge For The Tretment Of Acne Vulgaris." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 497–513. https://doi.org/10.5281/zenodo.13910723.

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Acne vulgaris is a common dermatological condition that affects a significant portion of the population, particularly adolescents and young adults. The need for effective topical treatments has led to the exploration of novel drug delivery systems. This study focuses on the formulation and characterization of nadifloxacin-loaded microsponge systems aimed at enhancing the therapeutic efficacy and skin penetration of the drug. Nadifloxacin, a potent topical antibiotic, is known for its effectiveness against acne-causing bacteria but is limited by its poor skin permeation and stability. Microspon

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Shreya, Parihar Nazneen Dubey Bharti Choudhary Shubhangi Nema. "A Review -Microsponges For The Treatment Of Acne Vulgaris." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 480–96. https://doi.org/10.5281/zenodo.13910743.

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Acne vulgaris is a common dermatological condition that affects a significant portion of the population, particularly adolescents and young adults. The need for effective topical treatments has led to the exploration of novel drug delivery systems. This study focuses on the formulation and characterization of nadifloxacin-loaded microsponge systems aimed at enhancing the therapeutic efficacy and skin penetration of the drug. Nadifloxacin, a potent topical antibiotic, is known for its effectiveness against acne-causing bacteria but is limited by its poor skin permeation and stability. Microspon

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Jain, Monal Yogesh, and Gunjan Jadon. "Evaluating the Effectiveness of Microsponge-based Topical Formulations Compared to Traditional Methods." Journal of Pharmaceutical Research International 36, no. 8 (2024): 204–22. http://dx.doi.org/10.9734/jpri/2024/v36i87571.

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The growing interest in microsponge-based topical formulations compared to traditional ones is shaping the future of skincare and pharmaceutical treatments. Microsponges are gaining attention for their ability to enhance drug stability, control release, and target specific areas, which could lead to better therapeutic outcomes and improved patient experiences. In this review, we dive into how these innovative formulations stack up against conventional methods. We start by exploring what makes microsponge technology unique—their structure, how they work, and the benefits they offer. We then loo

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Tushir, Renu, Manish Dhall Dhall, and Nidhi Goel. "Preparation and In-Vitro Evaluation of Anti-Fungal Activity of Clotrimazole Loaded Microsponge based Gel." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7808–20. https://doi.org/10.37285/ijpsn.2025.18.1.8.

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Background: Numerous attempts have been made that divert from the usual delivery systems for dermatological applications to uplift us onto the development of their substitute. In the last few decades, microsponges have come into existence as an alternative for the delivery of medicaments through a topical route. The small size of a particle delivers benefits that make them preferable to the modern micro carriers. Microsponge-based gels are growing as new progress for delivering the feebly aqueous soluble drugs at the site of action. Aim: The present research furnishes the formulation, evaluati

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Baranauskaite, Juste, Sedef Sefer, Augusta Zevzikoviene, Andrejus Zevzikovas, and Liudas Ivanauskas. "Optimized Enoxolone-Loaded Microsponges for Drug Delivery: A Design of Experiments Approach." Pharmaceuticals 18, no. 7 (2025): 938. https://doi.org/10.3390/ph18070938.

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Enoxolon is widely recognized for its pharmacological potential, exhibiting antioxidant, anti-inflammatory, anticancer, and antiviral properties. Objectives: This study aimed to develop an enhanced formulation of enoxolone-loaded microsponges as a novel drug delivery system. A design of experiments (DoE) approach was employed for the optimization process. Methods: The microsponges were produced using the quasi-emulsion technique. The selected formulation was evaluated for yield, particle size, and entrapment efficiency. Furthermore, the microsponges were incorporated into a 1% MC solution matr

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