Relevant bibliographies by topics / Modular PKS engineering

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Modular PKS engineering'

Author: Grafiati
Published: 8 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Modular PKS engineering"

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Beck, Charlotte, Jaime Felipe Guerrero Garzón, and Tilmann Weber. "Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines." Biotechnology and Bioprocess Engineering 25, no. 6 (2020): 886–94. http://dx.doi.org/10.1007/s12257-020-0265-5.

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Wesener, Shane R., Vishwakanth Y. Potharla, and Yi-Qiang Cheng. "Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase." Applied and Environmental Microbiology 77, no. 4 (2010): 1501–7. http://dx.doi.org/10.1128/aem.01513-10.

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ABSTRACTFunctional cross talk between fatty acid biosynthesis and secondary metabolism has been discovered in several cases in microorganisms; none of them, however, involves a modular biosynthetic enzyme. Previously, we reported a hybrid modular nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) pathway for the biosynthesis of FK228 anticancer depsipeptide inChromobacterium violaceumstrain 968. This pathway contains two PKS modules on the DepBC enzymes that lack a functional acyltransferase (AT) domain, and no apparent AT-encoding gene exists within the gene cluster or its vicin
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Musiol-Kroll, Ewa, and Wolfgang Wohlleben. "Acyltransferases as Tools for Polyketide Synthase Engineering." Antibiotics 7, no. 3 (2018): 62. http://dx.doi.org/10.3390/antibiotics7030062.

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Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others. Their structures are assembled by polyketide synthases (PKSs). Modular PKSs are composed of modules, which involve sets of domains catalysing the stepwise polyketide biosynthesis. The acyltransferase (AT) domains and their “partners”, the acyl carrier proteins (ACPs), thereby play an essential role. The AT loads the building blocks onto the “substrate acceptor”, the ACP. Thus, the AT dictates which building blo
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Rascher, Andreas, Zhihao Hu, Greg O. Buchanan, Ralph Reid, and C. Richard Hutchinson. "Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption." Applied and Environmental Microbiology 71, no. 8 (2005): 4862–71. http://dx.doi.org/10.1128/aem.71.8.4862-4871.2005.

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ABSTRACT Geldanamycin and the closely related herbimycins A, B, and C were the first benzoquinone ansamycins to be extensively studied for their antitumor properties as small-molecule inhibitors of the Hsp90 protein chaperone complex. These compounds are produced by two different Streptomyces hygroscopicus strains and have the same modular polyketide synthase (PKS)-derived carbon skeleton but different substitution patterns at C-11, C-15, and C-17. To set the stage for structural modification by genetic engineering, we previously identified the gene cluster responsible for geldanamycin biosynt
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He, Yunlong, Yuhui Sun, Tiangang Liu, Xiufen Zhou, Linquan Bai, and Zixin Deng. "Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification." Applied and Environmental Microbiology 76, no. 10 (2010): 3283–92. http://dx.doi.org/10.1128/aem.02262-09.

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ABSTRACT Five meilingmycins, A to E, with A as the major component, were isolated from Streptomyces nanchangensis NS3226. Through nuclear magnetic resonance (NMR) characterization, meilingmycins A to E proved to be identical to reported milbemycins α11, α13, α14, β1, and β9, respectively. Sequencing of a previously cloned 103-kb region identified three modular type I polyketide synthase genes putatively encoding the last 11 elongation steps, three modification proteins, and one transcriptional regulatory protein for meilingmycin biosynthesis. However, the expected loading module and the first
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Haydock, Stephen F., Anthony N. Appleyard, Tatiana Mironenko, John Lester, Natasha Scott, and Peter F. Leadlay. "Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449." Microbiology 151, no. 10 (2005): 3161–69. http://dx.doi.org/10.1099/mic.0.28194-0.

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The macrolide antibiotic concanamycin A has been identified as an exceptionally potent inhibitor of the vacuolar (V-type) ATPase. Such compounds have been mooted as the basis of a potential drug treatment for osteoporosis, since the V-ATPase is involved in the osteoclast-mediated bone resorption that underlies this common condition. To enable combinatorial engineering of altered concanamycins, the biosynthetic gene cluster governing the biosynthesis of concanamycin A has been cloned from Streptomyces neyagawaensis and shown to span a region of over 100 kbp of contiguous DNA. An efficient trans
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Agergaard, Julie Krogh, Kristoffer Wernblad Sigsgaard, Niels Henrik Mortensen, Simon Didriksen, Kasper Barslund Hansen, and Jingrui Ge. "MODULAR MAINTENANCE DECISION ARCHITECTURE." Proceedings of the Design Society 3 (June 19, 2023): 2715–24. http://dx.doi.org/10.1017/pds.2023.272.

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AbstractThe operation of large production assets requires many decisions from the acquisition and design of new assets to the choice of lubricant for a specific piece of equipment. The decisions made in maintenance have a direct effect on the management of the production process, making it important to ensure correct maintenance decision making. However, studies on maintenance decision making tend to focus on smaller areas of decisions being made in a process, but rarely the entire process. To introduce more studies that consider the entire maintenance process, this paper proposes using a modu
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Wang, Guimei, Lijie Yang, and Yong Shuo Zhang. "Modularized design of coal-mine paste filling station based on fuzzy theory." World Journal of Engineering 15, no. 6 (2018): 743–50. http://dx.doi.org/10.1108/wje-01-2018-0006.

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Purpose This paper aims to study a modular method for designing a paste filling station (PFS) for a coal mine (CM) to reduce the PFS’s input cost and achieve reutilization. Design/methodology/approach Modular design criteria for the PFS are proposed and a modular division (MDiv) model and an evaluation method are established. The correlation-strength matrix of the PFS parts expressed in the form of rough numbers is transformed into a fuzzy equivalent matrix. The theory of rough sets and the fuzzy clustering method are introduced for PFS MDiv. The evaluating method is established for the PFS MD
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Rana, Vighneshkumar, and Vishal Singh. "Analyzing the dimensional aspects of 3D volumetric spaces: a product-oriented perspective." Proceedings of the Design Society 4 (May 2024): 2433–42. http://dx.doi.org/10.1017/pds.2024.246.

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AbstractThe concept of volumetric spaces has evolved in the Architecture, Engineering, and Construction (AEC) sector, ranging from traditional onsite built spaces to modern modular houses and portable architecture. Despite this diversity, there lacks a comprehensive framework to analyze volumetric space products across dimensions. This paper presents a conceptual framework based on abductive reasoning and qualitative analysis, aiming to explore interdependencies among dimensions. It hypothesizes that volumetric space dimensions are perceived differently and demonstrate interdependencies.
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Neroda, T., and Ya Uhryn. "Engineering the modular architecture of industrial pcs for sustaining automation systems in operational printing." Computer Technologies of Printing 1, no. 51 (2024): 19–34. http://dx.doi.org/10.32403/2411-9210-2024-1-51-19-34.

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Dissertations / Theses on the topic "Modular PKS engineering"

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Su, Li. "Generation of analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0081.

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Les polycétides d’origine bactérienne sont une source importante de molécules anti-infectieuses et anticancéreuses d’origine naturelle utilisées en thérapie. Cependant, leurs structures doivent souvent être optimisées afin d'améliorer leurs propriétés thérapeutiques. Les stambomycines, une famille de macrolides parmi les plus grands polycétides connus (elles possèdent un noyau macrolactone à 51 membres), ont été récemment découvertes par une approche de genome mining chez la bactérie Streptomyces ambofaciens ATCC23877. Ces molécules présentent une activité anticancéreuse prometteuse. Six forme
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Zarzoso, Vicente. "Traitement aveugle et semi-aveugle du signal pour les télécommunications et le génie biomédical." Habilitation à diriger des recherches, Université de Nice Sophia-Antipolis, 2009. http://tel.archives-ouvertes.fr/tel-00486872.

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Ce rapport résume mes activités de recherche depuis l'obtention de mon doctorat. Je me suis penché sur le problème fondamental de l'estimation de signaux sources à partir de l'observation de mesures corrompues de ces signaux, dans des scénarios où les données mesurées peuvent être considérées comme une transformation linéaire inconnue des sources. Deux problèmes classiques de ce type sont la déconvolution ou égalisation de canaux introduisant des distorsions linéaires, et la séparation de sources dans des mélanges linéaires. L'approche dite aveugle essaie d'exploiter un moindre nombre d'hypoth
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Book chapters on the topic "Modular PKS engineering"

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JianBing, Chen. "PEEK and PES ☆." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-803581-8.02607-2.

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Zhao Xiaojia and Curran Richard. "Aero-Structure Direct Operating Cost Estimation and Sensitivity Analysis Within a Knowledge Based Engineering System." In 20th ISPE International Conference on Concurrent Engineering. IOS Press, 2013. https://doi.org/10.3233/978-1-61499-302-5-578.

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This paper presents a methodology to incorporate Direct Operating Cost (DOC), Surplus Value (SV) and Sensitivity Analysis (SA) into a Knowledge Based Engineering (KBE) system. Based on a parametrically modeled product geometry, the system automatically generates manufacturable geometry as well as the material and production data required by the Product Breakdown Structure (PBS) and the Bill Of Materials (BOM). By taking each item from the BOM, DOC is estimated using a production cost module and simplified weight estimation module. The presented application is able to perform an SA with respect
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Motloung, Mpho Phillip, Orebotse Joseph Botlhoko, and Suprakas Sinha Ray. "Biodegradable PBS, PBSA, and PBAT Based Systems." In Reference Module in Materials Science and Materials Engineering. Elsevier, 2024. https://doi.org/10.1016/b978-0-323-95486-0.00084-3.

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Berthelot P., Durand F., and Pal O. "Gonflement et chemin de contraintes sur les caractéristiques de sol dans le dimensionnement des ouvrages." In Proceedings of the 17th International Conference on Soil Mechanics and Geotechnical Engineering. IOS Press, 2009. https://doi.org/10.3233/978-1-60750-031-5-1429.

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Au-delà de la problématique liée à la variabilité spatiale in-situ des matériaux potentiellement gonflants, l'expérience montre qu'il est bien difficile d'apprécier une pression de gonflement et les caractéristiques de cisaillement car les différents modes opératoires dont on dispose aujourd'hui conduisent dans la plupart des cas à des valeurs bien disparates. Cette dispersion n'est bien évidemment pas sans incidence sur le dimensionnement des projets g
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Glinsky, Albert. "A Eunuch in a Harem." In Switched On. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197642078.003.0008.

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Abstract The Abominatron was an unexpected hit at the 1964 Audio Engineering Society (AES) convention, attracting the attention of luminaries and musical heavy-hitters such as Alwin Nikolais, Eric Siday, Lejaren Hiller, and people from the Columbia-Princeton Electronic Music Center. Bob found himself taking orders for modules, something he’d never anticipated. Nikolais and Siday become his first customers. But in the meantime, he needed to roll out the high-end amp (dubbed the PMS-15) because the business had lost $28,000. Tooling up to produce 100, he ended up selling three—a catastrophic end
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Subirats, X., E. Fuguet, M. Rosés, E. Bosch, and C. Ràfols. "Methods for pKa Determination (I): Potentiometry, Spectrophotometry, and Capillary Electrophoresis." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11559-8.

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Chen, Sichao, Deqiang Lian, Qi Cai, et al. "Multifunctional Operation Strategy of Paralleled VSG Based on Droop Control and Improved Second-Order Generalized Integrator Phase-Locked Loop." In Advances in Transdisciplinary Engineering. IOS Press, 2024. https://doi.org/10.3233/atde241281.

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With global resource shortages and environmental degradation, the development of clean energy has become a key focus. The increasing integration of distributed renewable energy sources like solar and wind into the grid presents challenges due to their instability, affecting microgrid voltage and frequency. Frequency stability is crucial for the grid operation and user safety, with fluctuations potentially causing equipment failures. The Power Conversion System (PCS), as the core of energy storage systems, must provide traditional charge/discharge functions and off-grid power during outages for
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Fuguet, E., X. Subirats, C. Ràfols, E. Bosch, and M. Rosés. "Methods for pKa Determination (II): Sparingly Soluble Compounds and High-Throughput Approaches." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11631-2.

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Baguelin F., Lay L., Ung S.Y., and Sanfratello J.P. "Pressiomètre, surconsolidation et tassement dans les sols fins." In Proceedings of the 17th International Conference on Soil Mechanics and Geotechnical Engineering. IOS Press, 2009. https://doi.org/10.3233/978-1-60750-031-5-961.

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On confronte les résultats des deux formules de tassement pressiométrique, l'une relative aux remblais et radiers, l'autre relative aux semelles, aux valeurs mesurées sur 15 remblais ou radiers et sur 19 semelles. La comparaison donne des résultats concordants et acceptables en pratique. La différence entre les deux formules est ensuite expliquée en relation avec la pression de surconsolidation des sols fins, en particulier à l'aide d'une étude théorique menée avec le modèle
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Thépot Olivier and Frank Roger. "Etude en petites déformations de l'interaction entre une fondation superficielle et une conduite enterrée." In Proceedings of the 16th International Conference on Soil Mechanics and Geotechnical Engineering. IOS Press, 2005. https://doi.org/10.3233/978-1-61499-656-9-989.

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Cette communication présente la modélisation par la méthode des éléments finis de l'interaction entre une fondation superficielle et une conduite enterrée. On compare une loi élastoplastique (critère de Mohr-Coulomb) à partie élastique linéaire avec une loi élastoplastique à élasticité non linéaire. On montre que la loi élastoplastique à élasticité linéaire ne permet
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Conference papers on the topic "Modular PKS engineering"

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Passarapark, Kunanon, Chuanchom Aumnate, Orathai Boondamnoen, and Pranut Potiyaraj. "Polyhydroxybutyrate/Polylactic Acid/Polybutylene Succinate Blend Filaments for 3D Printing Applications." In 2024 8th International Conference on Materials Engineering and Nano Sciences & 2024 8th International Conference on Material Engineering and Manufacturing. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-gzenp4.

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Biopolymers have gained increased attention as viable alternatives to petroleum-based polymers, driven by growing awareness of sustainability and environmental impact. Polyhydroxybutyrate (PHB), a biopolymer derived from microorganisms, holds promise for biomedical applications due to its unique properties. However, its practical use has been hindered by certain limitations. In this study, we addressed these challenges by preparing blends of PHB with polylactic acid (PLA) and polybutylene succinate (PBS) using a twin-screw extruder. The thermal analysis revealed a reduction in the degree of cr
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Liang, Gaige, JinSu Tian, Beibei Li, Shidong Li, Xiangchen Liu, and Chaoqun Lu. "Research on Control Strategies of Modular Multilevel Converter Based on Three-Level Controllers." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922427.

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Zhao, Le, Ling Xu, Xiaohu Zhang, et al. "Compact Galvanic Isolated Modular Multilevel High Voltage DC/DC Transformer and its Control Scheme in Full DC System." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922710.

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He, Shangyang, Jinpeng Tian, Weijie Mai, Zipeng Liang, Hanjiang Dong, and Chi Yung Chung. "Allocating the Power Module for Future EV: a Constraints Learning Approach." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922550.

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Wang, Haojing, Deyang Yin, Yu Zhang, Qin Xu, Chen Fang, and Yuanyuan Zhu. "Soft Faults Diagnosis Based on LightGBM in Lithium-Ion Battery Module." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922274.

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Huan, Junjie, Mi Wen, Qipei Zhang, and Wenteng Kuang. "Electric Vehicle Load Forecasting Based on Time Series Decomposition and CPIKS Module." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922661.

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Puyu, Wang, Lin Zhengdong, An Yucong, Gu Xinxin, and Ding Yifan. "Real-Time Junction Temperature Monitoring Method for IGBT Power Modules of VSC Converters Based on Digital Twin Technology." In 2024 IEEE PES 16th Asia-Pacific Power and Energy Engineering Conference (APPEEC). IEEE, 2024. https://doi.org/10.1109/appeec61255.2024.10922609.

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Zhang, Dan, Lihui Wang, and Sherman Y. T. Lang. "Modelling and Control of PKM in an Integrated Environment." In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/cie-48178.

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This paper introduces an integrated validation system that consists of the following modular components: kinematic/dynamic analysis module, kinetostatic model, CAD module, FEM module, CAM module, optimization module and visual environment for remote control. In this paper, authors focus mainly on the modules of kinetostatic modeling, dynamic modeling, PKM design optimization, and remote control realization. The prototype of a 3-dof PKM developed at NRC-IMTI is used as an example throughout this paper.
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Kitzmiller, John T., Richard G. Anderson, Laura L. Genutis, and Dennis M. Popp. "Effects on Core Damage Frequency to Sensitivity of Instrumentation and Control Reliability." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75413.

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Core Damage Frequency (CDF) and Large Release Frequency (LRF) can be greatly affected by the application of Instrumentation and Control (I&C) within the control and safety systems utilized in the operations of a nuclear power plant. It is important that the modeling of these systems be an accurate representation of the I&C design to capture the effects of the I&C on the operations of the nuclear power plant as far as control and safety that are needed for the effective and safe operation of power generation. Various sensitivities can be performed on I&C modeling in the AP1000 P
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Han, Changwan, Seonghun Park, and Hanjong Kim. "Dynamic Response of Polyvinyl Alcohol(PVA)-Hydrogel With Different PVA Concentrations." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37811.

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Polyvinyl Alcohol-Hydrogel (PVA-H) is a biomaterial used for manufacturing contact lenses as well as for the medium of drug delivery. Previous studies have also showed that PVA-H exhibits superior biocompatibility with hydrophilic elastic nature. The aim of this study is to examine the possible usage of the PVA-H as cartilage replacement material by determining the static and dynamic mechanical properties of PVA-H with different ratios of polyvinyl alcohol (PVA) and phosphate buffered saline (PBS) compositions. Three different types of PVA-H specimens were made by changing the ratio of PVA (Si
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