Academic literature on the topic 'Molecular receptors'

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Journal articles on the topic "Molecular receptors"

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Brown, Michael, Michael Webb, Elsa Phillips, Elizabeth Skidmore, and Peter McIntyre. "Molecular studies on kinin receptors." Canadian Journal of Physiology and Pharmacology 73, no. 7 (July 1, 1995): 780–86. http://dx.doi.org/10.1139/y95-105.

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We describe the results of functional studies on DNA clones encoding functional bradykinin receptors derived from human, rat, and mouse sources and including both genomic and complementary DNA clones. In both the Xenopus oocyte and the COS cell expression systems, the receptors from human and rat showed the pharmacological properties of B2 receptors, but receptors from mouse displayed both B1- and B2-like pharmacological properties. We further investigated the molecular relationship between the B1 and B2 receptor subtypes expressed by a human fibroblast cell line, and we demonstrate that these
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Szybowska, Patrycja, Ellen Margrethe Haugsten, and Antoni Wiedlocha. "The canonical FGF-FGFR signaling system at the molecular level." Postępy Higieny i Medycyny Doświadczalnej 75, no. 1 (January 1, 2021): 711–19. http://dx.doi.org/10.2478/ahem-2021-0024.

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Abstract Extracellular signaling molecules, among them the fibroblast growth factors (FGFs), enable cells to communicate with neighboring cells. Such signaling molecules that receive and transmit a signal require specific tyrosine kinase receptors located at the cell surface (fibroblast growth factor receptors, FGFRs). The binding of a signaling molecule to its specific receptor results in receptor dimerization and conformational changes in the cytoplasmic part of the receptor. The conformational changes lead to trans-autophosphorylation of the tyrosine kinase domains of the receptors and subs
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Hay, D. L., G. Christopoulos, A. Christopoulos, and P. M. Sexton. "Amylin receptors: molecular composition and pharmacology." Biochemical Society Transactions 32, no. 5 (October 26, 2004): 865–67. http://dx.doi.org/10.1042/bst0320865.

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Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY1(a), AMY2(a) and AMY3(a) in accordance with the association of the CT receptor (CT(a)) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.
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Alfimov, Michael V., Olga A. Fedorova, and Sergey P. Gromov. "Photoswitchable molecular receptors." Journal of Photochemistry and Photobiology A: Chemistry 158, no. 2-3 (June 2003): 183–98. http://dx.doi.org/10.1016/s1010-6030(03)00033-9.

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Xie, Peng, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, and Wei Fu. "Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors." Molecules 27, no. 7 (March 28, 2022): 2173. http://dx.doi.org/10.3390/molecules27072173.

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Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by different agonists have been among the most important fields in opioid research. In this study, with compound M1, an active metabolite of tramadol, as the clue compound, several aminomethyl tetrahydronaphthalenes were designed, synthesized and assayed upon opioid receptors. With the resultant compounds FW-AII-OH-1 (Ki = 141.2 nM for the κ opioid r
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Breyer, M. D., H. R. Jacobson, and R. M. Breyer. "Functional and molecular aspects of renal prostaglandin receptors." Journal of the American Society of Nephrology 7, no. 1 (January 1996): 8–17. http://dx.doi.org/10.1681/asn.v718.

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The diverse intrarenal effects of the prostaglandins (PG) are mediated by distinct guanine nucleotide regulatory protein (G-protein)-coupled receptors. The cDNA for these receptors have been cloned, their signal transduction mechanisms determined, and their intrarenal distribution mapped. PGE2, the major intrarenal prostaglandin, interacts with at least three distinct E-prostanoid (EP) receptors that are highly expressed in specific regions of the kidney. Each EP receptor not only selectively binds PGE2, but also preferentially couples to different signal transduction pathways, including: stim
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North, R. Alan. "Molecular Physiology of P2X Receptors." Physiological Reviews 82, no. 4 (January 10, 2002): 1013–67. http://dx.doi.org/10.1152/physrev.00015.2002.

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P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40–50% identical in amino acid sequence. Each subunit has two transmembrane domains, separated by an extracellular domain (∼280 amino acids). Channels form as multimers of several subunits. Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7channels and heteromeric P2X2/3and P2X1/5channels have been most fully characterized following heterologous expression. Some agonists (e.g., αβ-methylene ATP) and antagonists [e.g., 2′,3′- O-(2,4,
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Livingstone, C. D., P. G. Strange, and L. H. Naylor. "Molecular modelling of D2-like dopamine receptors." Biochemical Journal 287, no. 1 (October 1, 1992): 277–82. http://dx.doi.org/10.1042/bj2870277.

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Three-dimensional computer models of the rat D2, D3 and D4 dopamine receptor subtypes have been constructed based on the diffraction co-ordinates for bacteriorhodopsin, another membrane-bound protein containing seven transmembrane domains presumed to be arranged in a similar spatial orientation. Models were assembled by aligning the putative transmembrane domains of the dopamine receptors with those of bacteriorhodopsin using sequence similarities, and then superimposing these modelled alpha-helices on to the bacteriorhodopsin-derived co-ordinates. These models explore the potential hydrogen b
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Behzadi, Payam, Herney Andrés García-Perdomo, and Tomasz M. Karpiński. "Toll-Like Receptors: General Molecular and Structural Biology." Journal of Immunology Research 2021 (May 29, 2021): 1–21. http://dx.doi.org/10.1155/2021/9914854.

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Background/Aim. Toll-like receptors (TLRs) are pivotal biomolecules in the immune system. Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune system to each other. The TLRs are activated through binding to damage/danger-associated molecular patterns (DAMPs), microbial/microbe-associated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), and xenobiotic-associated molecular patterns (XAMPs). The immunogenetic molecules of TLRs have their own functions, structures, coreceptors, and ligands which make them unique. These properties of TL
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Bettler, Bernhard, Klemens Kaupmann, Johannes Mosbacher, and Martin Gassmann. "Molecular Structure and Physiological Functions of GABAB Receptors." Physiological Reviews 84, no. 3 (July 2004): 835–67. http://dx.doi.org/10.1152/physrev.00036.2003.

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GABAB receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB receptor cDNAs in 1997 revived interest in these receptors and their potential as therapeutic targets. With the availability of molecular tools, rapid progress was made in our understanding of the GABAB system. This led to the surprising discovery that GABAB receptors need to assemble from distinct subunits to function and provided exciting new insights into the structure of G protein-coupled receptors (GPCRs) in genera
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Dissertations / Theses on the topic "Molecular receptors"

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Björnström, Linda. "Molecular mechanisms of alternative estrogen receptor signaling /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-509-3/.

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Kovoor, Abraham. "Molecular regulation of opioid receptors /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6278.

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Meira, Guilherme Louzada Silva. "Analíse da expressão do receptor olfativo M93 em sistemas heterólogos." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31082016-115408/.

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O sistema olfatório de mamífero pode discriminar milhares de odores presentes no meio ambiente. Aproximadamente 1000 diferentes receptores olfatórios (ORs) são expressos no epitélio olfatório (OE) do nariz, Os ORs detectam os odores e transmitem os sinais resultantes para o bulbo olfatório (OB) no cérebro. Os ORs pertencem a super família dos receptores acoplados a proteína G (GPCR) e apresentam sete domínios transmembrânicos putativos. Por razões desconhecidas, os ORs são retidos no retículo endoplasmático quando expressos em linhagens de células de mamíferos heterólogas. Provavelmente, prote
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McGinley, Paula Lynn. "Molecular complementation of mutant hormone receptors." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 189 p, 2008. http://proquest.umi.com/pqdweb?did=1456289611&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Kuswandi, Susi Iravati. "Molecular genetic analysis of aerobactin receptors." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34438.

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Some Enterobacteriaceae produce a low molecular weight compound, aerobactin, with a high affinity for ferric iron. The genes encoding the aerobactin system have been identified in plasmid or chromosomal DNA; they are arranged in an operon consisting of five genes; four genes encode enzymes responsible for the biosynthesis of aerobactin and the fifth encodes an outer membrane receptor protein specific for ferric aerobactin. The aerobactin receptor protein appears to be different in size (molecular weight) in different species. Escherichia coli (ColV-K30) express a 74 kDa protein, while Shigella
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Beltrán, Sáez Elisa. "Information transmission through a nonlinear molecular signaling system: ErbB as a case study." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667354.

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La capacitat dels éssers vius d’obtenir i processar informació és clau per adaptar-se i sobreviure en l’ambient que els envolta. Les cèl·lules, des de procariotes unicel·lulars fins a organismes multicel·lulars (eucariotes), capten informació de l’entorn mitjançant diversos mecanismes, entre ells a través de receptors de membrana, que fan de canal per a la informació entre l’exterior i l’interior de la cèl·lula. Per tant, aquestos receptors representen un canal de transmissió d’informació a través del qual la informació ambiental pot afectar el comportament cel·lular per adaptar-se a l’ambient
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Zhang, Gaiping. "Bovine IgG Fc receptors." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387187.

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Torvinen, Maria. "Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-298-1/.

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Cordomí, Montoya Arnau. "Molecular dynamics simulations of seven-transmembrane receptors." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/6464.

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Seven transmembrane (7-TM) G protein coupled receptors (GPCR) constitute the largest family of integral membrane proteins in eukaryotes with more than 1000 members and encoding more than 2% of the human genome. These proteins play a key role in the transmission and transduction of cellular signals responding to hormones, neurotransmitters, light and other agonists, regulating basic biological processes. Their natural abundance together with their localization in the cell membrane makes them suitable targets for therapeutic intervention. Consequently, GPCR are proteins with enormous pharmacolog
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Hodyl, Jozef Andrew Zbigniew, and jozef hodyl@flinders edu au. "Silica Immobilised Metal Ion Activated Molecular Receptors." Flinders University. School of Chemistry, Physics and Earth Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090301.162335.

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Immobilisation of functional entities, such as, enzymes, onto solid supports, as a means of facilitating their removal from the surrounding environment and subsequent regeneration has been in practice for many decades. This work focuses on the immobilisation and analysis of three-walled (pendant armed), cyclen based receptor complexes immobilised onto a silica surface for the purpose of sequestering aromatic anions from aqueous solution: Si-GPS-[Cd(Trac)](ClO4)2, Si-GPS-[Cd(DiPTrac)](ClO4)2, and Si-GPS-[Cd(TriPTrac)](ClO4)2 were the immobilised receptors used. Initially, synthesis of a three-
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Books on the topic "Molecular receptors"

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Conn, P. Michael. Receptor Molecular Biology: Receptor Molecular Biology. Burlington: Elsevier, 1995.

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Signals and receptors. Milton Keynes: Open University Press, 1986.

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Reisine, Terry. Molecular biology of neurotransmitter receptors. Amsterdam, Netherlands: Elsevier Science Publishers B.V., 1992.

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Linthicum, D. Scott, and Nadir R. Farid, eds. Anti-Idiotypes, Receptors, and Molecular Mimicry. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3734-1.

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Burch, Ronald M. Molecular biology and pharmacology of bradykinin receptors. Austin: R.G. Landes, 1993.

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Brann, Mark R., ed. Molecular Biology of G-Protein-Coupled Receptors. Boston, MA: Birkhäuser Boston, 1992. http://dx.doi.org/10.1007/978-1-4684-6772-7.

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Fozard, John R., and Pramod R. Saxena, eds. Serotonin: Molecular Biology, Receptors and Functional Effects. Basel: Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7259-1.

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Rumsby, Gill. Molecular endocrinology: Genetic analysis of hormones and their receptors. Oxford: BIOS Scientific, 1997.

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Freedman, Leonard P., ed. Molecular Biology of Steroid and Nuclear Hormone Receptors. Boston, MA: Birkhäuser Boston, 1998. http://dx.doi.org/10.1007/978-1-4612-1764-0.

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Kenakin, Terrence P. Molecular pharmacology: A short course. Cambridge, Mass: Blackwell Science, 1997.

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Book chapters on the topic "Molecular receptors"

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Müller, Judith M., and Roland Schüle. "Sex Steroid Receptors: Androgen Receptor, Estrogen Receptors, Progesterone Receptor." In Encyclopedia of Molecular Pharmacology, 1–7. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-21573-6_163-1.

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Müller, Judith M., and Roland Schüle. "Sex Steroid Receptors: Androgen Receptor, Estrogen Receptors, Progesterone Receptor." In Encyclopedia of Molecular Pharmacology, 1415–21. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_163.

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Lolait, Stephen J., James A. Roper, Georgina G. J. Hazell, Yunfei Li, Fiona J. Thomson, and Anne-Marie O'Carroll. "Neuropeptide Receptors." In Molecular Neuroendocrinology, 195–215. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118760369.ch10.

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Kay, Euan R., and David A. Leigh. "Synthetic Molecular Machines." In Functional Synthetic Receptors, 333–406. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/352760572x.ch7.

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Mocking, T. A. M., R. Bosma, S. N. Rahman, E. W. E. Verweij, Daniel A. McNaught-Flores, Henry F. Vischer, and Rob Leurs. "Molecular Aspects of Histamine Receptors." In Histamine Receptors, 1–49. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40308-3_1.

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Pedersen, Steen E. "Molecular Structure, Gating, and Regulation." In Nicotinic Receptors, 17–38. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1167-7_2.

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Ikemoto, Noriaki. "Intra-Molecular Domain-Domain Interaction." In Ryanodine Receptors, 53–65. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-23188-9_6.

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Murshid, Ayesha, Jimmy Theriault, Jianlin Gong, and Stuart K. Calderwood. "Molecular Chaperone Receptors." In Methods in Molecular Biology, 331–44. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7477-1_24.

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Lassègue, Bernard, Kathy K. Griendling, and R. Wayne Alexander. "Molecular Biology of Angiotensin II Receptors." In Angiotensin Receptors, 17–48. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2464-9_2.

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Rudkevich, Dmitry M. "Molecular Containers in Action." In Functional Synthetic Receptors, 257–98. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/352760572x.ch5.

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Conference papers on the topic "Molecular receptors"

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Batista, Victor de Sousa, Lourival Rodrigues de Sousa Neto, Roberto Ribeiro Faria, Keli Cristina Barbosa dos Reis та Nailton Monteiro do Nascimento Júnior. "Post-processing of docking results through docking-based comparative intermolecular contacts analysis (dbCICA) of the α4β2 and α7 nicotinic acetylcholine receptors (nAChRs)". У VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020146.

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The nAChRs are pentameric ligand-gated ionic channels that respond to the endogenous neurotransmitter acetylcholine, with the α4β2 and α7 subtypes being highly expressed in human brain. Those receptors are involved in many neurologic disorders such as Alzheimer’s disease and Schizophrenia, as well as in nicotine addiction. In this context, molecular modelling is a powerful tool for designing novel ligands targeting those receptors. In the present work, we applied dbCICA1 to identify optimal docking conditions for these two receptors. The methodology and results are summarized bellow. Briefly,
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Zhu, Cheng, and Scott E. Chesla. "Dissociation of Individual Molecular Bonds Under Force." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0286.

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Abstract Specific interactions between receptors on cell surfaces are essential for living organisms to sense and adapt to their environment. For example, CD16A (Feγ receptor IIIA) signals a variety of immune functions upon binding of immunoglobulin (Ig) G. While receptor-ligand binding has been extensively studied in chemical terms, only until very recently has direct measurement of individual bond forces become possible. Evans et al. [1] pioneered the use of the micropipet technique to measure detachment forces between two red blood cells (RBC) crosslinked by antibodies. While these authors
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Simone, E. R., T. A. Davies, N. A. Zabe, S. M. Greenberg-seperaky, and N. E. Larsen. "EARLY PLATELET-THROMBIN RECEPTORS AND THEIR FUNCTIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643730.

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Human platelets possess less than 1000 high affinity [Kd=10-9]and 50-100,000 receptors of lower [Kd=10-7] affinity for o(α-thrombin. The selective derivatization of thrombin with the bifunctional crosslinking agent, DNCO, has enabled us to identify these receptorsvia covalent binding of either active siteinhibited tosyllyslmethylketothrombin (TLCK-T) or active Ctf-thrombin (T).Kinetic studies of the inhibition of the platelet-thrombin response by covalently and noncovalently bound TLCK-T have helped to elucidate the roles of the high and low affinity thrombin receptors. The activation paramete
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Einolghozati, Arash, Mohsen Sardari, and Faramarz Fekri. "Capacity of diffusion-based molecular communication with ligand receptors." In 2011 IEEE Information Theory Workshop (ITW). IEEE, 2011. http://dx.doi.org/10.1109/itw.2011.6089591.

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Wu, Chunsheng, Liping Du, Ping Wang, and Luhang Zhao. "Olfactory receptors molecular sensors using surface acoustic wave chip." In 2011 IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2011. http://dx.doi.org/10.1109/nems.2011.6017571.

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Einolghozati, Arash, and Faramarz Fekri. "Rate-distortion in molecular signal sensing with ligand receptors." In 2015 IEEE International Symposium on Information Theory (ISIT). IEEE, 2015. http://dx.doi.org/10.1109/isit.2015.7282672.

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Geronymo, Beatriz Baaklini, Filomena Marino Carvalho, Adriana Akemi Yoshimura, Juliana Zabukas de Andrade, Danúbia Ariana de Andrade, and Alfredo Carlos Simões Dornellas de Barros. "CORRELATION BETWEEN THE PRESENCE OF ANDROGENIC RECEPTORS AND MOLECULAR AND HISTOPATHOLOGICAL VARIABLES IN BREAST CANCER." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1061.

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Introduction: The expression of androgenic receptors (AR) is a new predictive marker of response and prognosis in invasive breast carcinoma (BC). It emerges as a potential therapeutic target. Objectives: To evaluate the frequency of AR positivity and its correlation with molecular and histopathological parameters in infiltrative BC. Methods: Retrospective cohort study, analyzing 119 cases of non-metastatic invasive BC, seen at a private clinic. Hormonal receptors were screened by immunohistochemical reaction, and AR were considered positive when present in at least 10% of cells, ER and PR from
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LAZEBNY, O. E., I. V. LAZEBNAYA, and O. A. KOKSHAROVA. "PHYLOGENETIC ANALYSIS OF CYANOBACTERIAL GLUTAMATE-LIKE RECEPTORS: THE FIRST OVERLOOK." In 5TH MOSCOW INTERNATIONAL CONFERENCE "MOLECULAR PHYLOGENETICSAND BIODIVERSITY BIOBANKING". TORUS PRESS, 2018. http://dx.doi.org/10.30826/molphy2018-53.

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Crow, Matthew J., Kevin Seekell, Stella Marinakos, Julie Ostrander, Ashutosh Chilkoti, and Adam P. Wax. "Hyperspectral molecular imaging of multiple receptors using immunolabeled plasmonic nanoparticles." In SPIE BiOS, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2011. http://dx.doi.org/10.1117/12.874093.

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ZHANG, YONG, YA-CHUN LEI, and DIAN-SHENG LIU. "MOLECULAR RECOGNITION OF AMINO ACIDS BY HEMATOPORPHYRIN AND METALLOHEMATOPORPHYRIN RECEPTORS." In Proceedings of the 15th International Symposium. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812839589_0106.

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Reports on the topic "Molecular receptors"

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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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Sasaki, D. Y., T. M. Alam, and R. A. Assink. Synthetic molecular receptors for phosphates and phosphonates in sol-gel materials. Office of Scientific and Technical Information (OSTI), December 1997. http://dx.doi.org/10.2172/563827.

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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, January 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are
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Sessa, Guido, and Gregory Martin. role of FLS3 and BSK830 in pattern-triggered immunity in tomato. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7604270.bard.

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Pattern-recognition receptors (PRRs) located on the plant cell surface initiate immune responses by perceiving conserved pathogen molecules known as pathogen-associated molecular patterns (PAMPs). PRRs typically function in multiprotein complexes that include transmembrane and cytoplasmickinases and contribute to the initiation and signaling of pattern-triggered immunity (PTI). An important challenge is to identify molecular components of PRR complexes and downstream signaling pathways, and to understand the molecular mechanisms that mediate their function. In research activities supported by
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist bioph
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. Learning from Nature How to Design Anti-insect Selective Pesticides - Clarification of the Interacting Face between Insecticidal Toxins and their Na-channel Receptors. United States Department of Agriculture, January 2010. http://dx.doi.org/10.32747/2010.7697101.bard.

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Structural details on the interacting faces of toxins and sodium channels (Navs), and particularly identification of elements that confer specificity for insects, are difficult to approach and require suitable experimental systems. Therefore, natural toxins capable of differential recognition of insect and mammalian Navs are valuable leads for design of selective compounds in insect control. We have characterized several scorpion toxins that vary in preference for insect and mammalian Navs, and identified residues important for their action. However, despite many efforts worldwide, only little
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Sessa, Guido, and Gregory B. Martin. molecular link from PAMP perception to a MAPK cascade associated with tomato disease resistance. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597918.bard.

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The research problem: The detection of pathogen-associated molecular patterns (PAMPs) by plant pattern recognition receptors (PRRs) is a key mechanism by which plants activate an effective immune response against pathogen attack. MAPK cascades are important signaling components downstream of PRRs that transduce the PAMP signal to activate various defense responses. Preliminary experiments suggested that the receptor-like cytoplasmickinase (RLCK) Mai5 plays a positive role in pattern-triggered immunity (PTI) and interacts with the MAPKKK M3Kε. We thus hypothesized that Mai5, as other RLCKs, fun
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. face of interaction of anti-insect selective toxins with receptor site-3 on voltage-gated sodium channels as a platform for design of novel selective insecticides. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7699857.bard.

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Voltage-gated sodium channels (Navs) play a pivotal role in excitability and are a prime target of insecticides like pyrethroids. Yet, these insecticides are non-specific due to conservation of Navs in animals, raising risks to the environment and humans. Moreover, insecticide overuse leads to resistance buildup among insect pests, which increases misuse and risks. This sad reality demands novel, more selective, insect killers whose alternative use would avoid or reduce this pressure. As highly selective insect toxins exist in venomous animals, why not exploit this gift of nature and harness t
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DuSell, Carolyn. Molecular Determinants of Estrogen Receptor Alpha Stability. Fort Belvoir, VA: Defense Technical Information Center, July 2008. http://dx.doi.org/10.21236/ada494436.

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DuSell, Carolyn D. Molecular Determinants of Estrogen Receptor Alpha Stability. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada473731.

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