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Relevant bibliographies by topics / Mono-carbonyl analogs of curcumin

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Journal articles

Academic literature on the topic 'Mono-carbonyl analogs of curcumin'

Author: Grafiati

Published: 6 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Mono-carbonyl analogs of curcumin"

1

MaruYama, Takashi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, and Hiroyuki Shibata. "Mono-Carbonyl Curcumin Analogs for Cancer Therapy." Biological and Pharmaceutical Bulletin 46, no. 6 (2023): 756–63. http://dx.doi.org/10.1248/bpb.b23-00103.

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2

Huda, Muhammad Badrul, Endang Astuti та Tri Joko Raharjo. "Synthesis of Mono-Ketone Curcumin Analogs from 3-Benzyloxybenzaldehyde and their Activity Assay as Inhibitor of α-Amylase". Key Engineering Materials 884 (травень 2021): 304–11. http://dx.doi.org/10.4028/www.scientific.net/kem.884.304.

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Synthesis, characterization, and biological evaluation of mono-ketone curcumin analogs as an inhibitor of α-amylase enzyme have been conducted. This research was initiated by synthesizing 3-benzyloxybenzaldehyde from 3-hydroxybenzaldehyde using benzyl chloride, potassium iodide, and potassium carbonate in dimethylformamide under reflux condition for an hour. Synthesis of monoketone curcumin analogs was performed through Claisen-Schmidt reaction by refluxing 3-benzyloxybenzaldehyde with acetone (analog A), cyclopentanone (analog B), and cyclohexanone (analog C) using potassium hydroxide 5% as a

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3

Yu, Pan, Weiya Cao, Linguo Zhao, et al. "Design, Synthesis, and Antitumor Evaluation of Novel Mono-Carbonyl Curcumin Analogs in Hepatocellular Carcinoma Cell." Pharmaceuticals 15, no. 8 (2022): 950. http://dx.doi.org/10.3390/ph15080950.

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Curcumin is a polyphenolic natural product that has promising anticancer properties. However, its clinical utility is limited by its chemical instability and poor metabolic properties. In this paper, a series of new curcumin analogs were synthesized and found to be potent antiproliferative agents against the HepG2 cell line by MTT assay. In general, Group B with single ketone and group C with chalcone were markedly more cytotoxic than group A with diketone. Compound B5 was found as the most potent analog (IC50 = 11.33 μM) compared to curcumin (IC50 = 32.83 μM) and the mechanism of its cytotoxi

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4

A, Kumar Maddineni, Rao Chunduri V, and Raju Begari N. "Synthesis and Characterization of Novel Mono Carbonyl Curcumin Analogues of Pyrazole Derivatives." Der Pharma Chemica 13, no. 1 (2021): 6. https://doi.org/10.5281/zenodo.13644078.

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(E)-4-aryl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-one derivatives were (4a-d) synthesized by the condensation of 3-aryl-1-phenyl-1H-pyrazole-4- carbaldehyde derivatives (3a-d) with acetone in the presence of sodium hydroxide. Compounds (4a-d) on condensation with different aldehydes give mono carbonyl curcumin analogues (MACs) of pyrazole derivatives (6a-x) in good yield.

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5

Hussain, Haya, Shujaat Ahmad, Syed Wadood Ali Shah, et al. "Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies." Molecules 26, no. 23 (2021): 7168. http://dx.doi.org/10.3390/molecules26237168.

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Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further investigated for in vivo neuroprotective and memory enhancing effects in scopolamine-induced amnesia using elevated plus maze (EPM) and novel object recognition (NOR) behavioral mice models. The effects of the synthesized compounds on the cholinergic system involvement in the brain hippocampus and their binding mode in the active site of cholineste

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6

Tantriasa, Lana D. T., Chairil Anwar та Endang Astuti. "Synthesis of Curcumin Analogs under Ultrasound Irradiation for Inhibiting α-Amylase". Materials Science Forum 948 (березень 2019): 115–19. http://dx.doi.org/10.4028/www.scientific.net/msf.948.115.

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Curcumin has biological properties because of its special characteristic of structure. Mono-ketone analogs curcumin show a better pharmacokinetics than curcumin itself. Curcumin analogs 1 and 2 were synthesized from 3,5-dimethoxybenzaldhyde and acetone (analog 1) and cyclohexanone (analog 2) under ultrasound irradiation at room temperature for 15-30 minutes and the yield of each analogs is 82.40% and 77.52%. Analog curcumin 1 and 2 were tested the inhibitory activity towards α-amylase enzyme with acarbose as a positive control. The inhibitory activity of α-amylase is determined by measure the

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7

Muhanad, T. Almayyahi, A. Saleh Basil, and A. Almayyahi Baqer. "Synthesis and Characterization of Some New Copolyester from Curcumin Mono-Carbonyl Analogues." Biomedicine and Chemical Sciences 1, no. 3 (2022): 147–59. https://doi.org/10.48112/bcs.v1i3.179.

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Nine copolyesters were prepared from a dicarboxylic acid, curcumin analogues (monocarbonyl) and phenophthalene dye in the mole ratio of 2:1:1 by direct polycondensation using triethylamine (Et<sub>3</sub>N) as the condensation agent. The dicarboxylic used is 2,6-Pyridine dicarbonyl dichloride acid. The curcumin analogues were prepared by acid catalyzed Aldol condensation reaction. These copolyesters were characterized by FT-IR. The fluorescence of the synthesized copolyesters was also investigated. Furthermore, Thermo gravimetric analysis (TGA) was used to investigate the thermal stability of

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8

Wang, Guangbao, Yinghui Li, Wei Sun, et al. "Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35." Pharmacology 105, no. 1-2 (2019): 79–89. http://dx.doi.org/10.1159/000502854.

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WZ35 is a monocarbonyl analog of curcumin, which had been proved advantage over curcumin in chemical stability and antitumor activity. However, its pharmacokinetic profile has not been determined. In the present study, an ultraperformance liquid chromatography-tandem mass spectrometry assay was developed to detect concentration of WZ35 in rat plasma. Subsequently, pharmacokinetic study showed that the oral bioavailability of WZ35 is 10.56%. Cytochrome P450 (CYP450) plays a major role in metabolizing exogenous substance. The concentration of WZ35 was sharply decreased while incubating with micr

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9

Wijianto, B., Ritmaleni, H. Purnomo, and A. Nurrochmad. "CURCUMIN MONO-CARBONYL ANALOGS AS POTENT ANTIBACTERIAL COMPOUNDS: SYNTHESIS, BIOLOGICAL EVALUATION AND DOCKING SIMULATION STUDY." Rasayan Journal of Chemistry 13, no. 02 (2020): 1153–65. http://dx.doi.org/10.31788/rjc.2020.1325554.

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10

Marbun, Prajona, Arief Rahman Hakim, Navista Sri Octa Ujiantari, Bambang Sulistyo Ari Sudarmanto, and Agung Endro Nugroho. "In Silico Pharmacokinetics Study of 2,5-Dibenzylidenecyclopentanone Analogs as Mono-Ketone Versions of Curcumin." BIO Web of Conferences 75 (2023): 04002. http://dx.doi.org/10.1051/bioconf/20237504002.

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The absorption-distribution-metabolism-excretion (ADME) profile is a crucial parameter that indicates the pharmacokinetics of the drug. The pharmacokinetic properties of a drug represent the fate of the drug in the body. Curcumin is a main compound in turmeric produced by plants of the Curcuma longa species, and has several pharmacological effects in animal and human clinical studies. However, preclinical and clinical studies have shown that curcumin has pharmacokinetic limitations such as poor bioavailability and rapid metabolism which restrict its widespread use. Therefore, various modificat

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