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Journal articles on the topic 'Mono-carbonyl analogs of curcumin'

Author: Grafiati

Published: 6 June 2025

Last updated: 2 August 2025

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1

MaruYama, Takashi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, and Hiroyuki Shibata. "Mono-Carbonyl Curcumin Analogs for Cancer Therapy." Biological and Pharmaceutical Bulletin 46, no. 6 (2023): 756–63. http://dx.doi.org/10.1248/bpb.b23-00103.

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2

Huda, Muhammad Badrul, Endang Astuti та Tri Joko Raharjo. "Synthesis of Mono-Ketone Curcumin Analogs from 3-Benzyloxybenzaldehyde and their Activity Assay as Inhibitor of α-Amylase". Key Engineering Materials 884 (травень 2021): 304–11. http://dx.doi.org/10.4028/www.scientific.net/kem.884.304.

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Synthesis, characterization, and biological evaluation of mono-ketone curcumin analogs as an inhibitor of α-amylase enzyme have been conducted. This research was initiated by synthesizing 3-benzyloxybenzaldehyde from 3-hydroxybenzaldehyde using benzyl chloride, potassium iodide, and potassium carbonate in dimethylformamide under reflux condition for an hour. Synthesis of monoketone curcumin analogs was performed through Claisen-Schmidt reaction by refluxing 3-benzyloxybenzaldehyde with acetone (analog A), cyclopentanone (analog B), and cyclohexanone (analog C) using potassium hydroxide 5% as a

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3

Yu, Pan, Weiya Cao, Linguo Zhao, et al. "Design, Synthesis, and Antitumor Evaluation of Novel Mono-Carbonyl Curcumin Analogs in Hepatocellular Carcinoma Cell." Pharmaceuticals 15, no. 8 (2022): 950. http://dx.doi.org/10.3390/ph15080950.

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Curcumin is a polyphenolic natural product that has promising anticancer properties. However, its clinical utility is limited by its chemical instability and poor metabolic properties. In this paper, a series of new curcumin analogs were synthesized and found to be potent antiproliferative agents against the HepG2 cell line by MTT assay. In general, Group B with single ketone and group C with chalcone were markedly more cytotoxic than group A with diketone. Compound B5 was found as the most potent analog (IC50 = 11.33 μM) compared to curcumin (IC50 = 32.83 μM) and the mechanism of its cytotoxi

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4

A, Kumar Maddineni, Rao Chunduri V, and Raju Begari N. "Synthesis and Characterization of Novel Mono Carbonyl Curcumin Analogues of Pyrazole Derivatives." Der Pharma Chemica 13, no. 1 (2021): 6. https://doi.org/10.5281/zenodo.13644078.

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(E)-4-aryl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-one derivatives were (4a-d) synthesized by the condensation of 3-aryl-1-phenyl-1H-pyrazole-4- carbaldehyde derivatives (3a-d) with acetone in the presence of sodium hydroxide. Compounds (4a-d) on condensation with different aldehydes give mono carbonyl curcumin analogues (MACs) of pyrazole derivatives (6a-x) in good yield.

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5

Hussain, Haya, Shujaat Ahmad, Syed Wadood Ali Shah, et al. "Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies." Molecules 26, no. 23 (2021): 7168. http://dx.doi.org/10.3390/molecules26237168.

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Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further investigated for in vivo neuroprotective and memory enhancing effects in scopolamine-induced amnesia using elevated plus maze (EPM) and novel object recognition (NOR) behavioral mice models. The effects of the synthesized compounds on the cholinergic system involvement in the brain hippocampus and their binding mode in the active site of cholineste

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6

Tantriasa, Lana D. T., Chairil Anwar та Endang Astuti. "Synthesis of Curcumin Analogs under Ultrasound Irradiation for Inhibiting α-Amylase". Materials Science Forum 948 (березень 2019): 115–19. http://dx.doi.org/10.4028/www.scientific.net/msf.948.115.

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Curcumin has biological properties because of its special characteristic of structure. Mono-ketone analogs curcumin show a better pharmacokinetics than curcumin itself. Curcumin analogs 1 and 2 were synthesized from 3,5-dimethoxybenzaldhyde and acetone (analog 1) and cyclohexanone (analog 2) under ultrasound irradiation at room temperature for 15-30 minutes and the yield of each analogs is 82.40% and 77.52%. Analog curcumin 1 and 2 were tested the inhibitory activity towards α-amylase enzyme with acarbose as a positive control. The inhibitory activity of α-amylase is determined by measure the

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7

Muhanad, T. Almayyahi, A. Saleh Basil, and A. Almayyahi Baqer. "Synthesis and Characterization of Some New Copolyester from Curcumin Mono-Carbonyl Analogues." Biomedicine and Chemical Sciences 1, no. 3 (2022): 147–59. https://doi.org/10.48112/bcs.v1i3.179.

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Nine copolyesters were prepared from a dicarboxylic acid, curcumin analogues (monocarbonyl) and phenophthalene dye in the mole ratio of 2:1:1 by direct polycondensation using triethylamine (Et<sub>3</sub>N) as the condensation agent. The dicarboxylic used is 2,6-Pyridine dicarbonyl dichloride acid. The curcumin analogues were prepared by acid catalyzed Aldol condensation reaction. These copolyesters were characterized by FT-IR. The fluorescence of the synthesized copolyesters was also investigated. Furthermore, Thermo gravimetric analysis (TGA) was used to investigate the thermal stability of

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8

Wang, Guangbao, Yinghui Li, Wei Sun, et al. "Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35." Pharmacology 105, no. 1-2 (2019): 79–89. http://dx.doi.org/10.1159/000502854.

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WZ35 is a monocarbonyl analog of curcumin, which had been proved advantage over curcumin in chemical stability and antitumor activity. However, its pharmacokinetic profile has not been determined. In the present study, an ultraperformance liquid chromatography-tandem mass spectrometry assay was developed to detect concentration of WZ35 in rat plasma. Subsequently, pharmacokinetic study showed that the oral bioavailability of WZ35 is 10.56%. Cytochrome P450 (CYP450) plays a major role in metabolizing exogenous substance. The concentration of WZ35 was sharply decreased while incubating with micr

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9

Wijianto, B., Ritmaleni, H. Purnomo, and A. Nurrochmad. "CURCUMIN MONO-CARBONYL ANALOGS AS POTENT ANTIBACTERIAL COMPOUNDS: SYNTHESIS, BIOLOGICAL EVALUATION AND DOCKING SIMULATION STUDY." Rasayan Journal of Chemistry 13, no. 02 (2020): 1153–65. http://dx.doi.org/10.31788/rjc.2020.1325554.

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10

Marbun, Prajona, Arief Rahman Hakim, Navista Sri Octa Ujiantari, Bambang Sulistyo Ari Sudarmanto, and Agung Endro Nugroho. "In Silico Pharmacokinetics Study of 2,5-Dibenzylidenecyclopentanone Analogs as Mono-Ketone Versions of Curcumin." BIO Web of Conferences 75 (2023): 04002. http://dx.doi.org/10.1051/bioconf/20237504002.

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The absorption-distribution-metabolism-excretion (ADME) profile is a crucial parameter that indicates the pharmacokinetics of the drug. The pharmacokinetic properties of a drug represent the fate of the drug in the body. Curcumin is a main compound in turmeric produced by plants of the Curcuma longa species, and has several pharmacological effects in animal and human clinical studies. However, preclinical and clinical studies have shown that curcumin has pharmacokinetic limitations such as poor bioavailability and rapid metabolism which restrict its widespread use. Therefore, various modificat

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11

Rahmawati, E. N., H. Y. Teruna, and A. Zhamri. "SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5-BIS((E)-METOKSI BENZILIDEN)-1-(FENILSULFONIL)-PIPERIDIN-4-ON." Photon: Jurnal Sain dan Kesehatan 9, no. 1 (2018): 151–58. http://dx.doi.org/10.37859/jp.v9i1.1074.

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A study has been conducted to synthesize analog of curcumin with base catalyzed condensation of 4-piperidone hydrochloride with substituted benzaldehyde under reflux led the formation of mono-carbonyl curcumin. The synthesized curcumin were further reacted with benzosulphonyl chloride by nucleophilic substitution of –NH group to afford 3,5-bis((E)-2-metoksi benziliden)-1-(fenilsulfonil)piperidin-4-on (EN-BS) compounds with excellent yield, 94%. Structure of the synthesized compounds were confirmed by UV, IR, MS and NMR spectra analysis. All the synthesized compounds were screened for their tox

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12

Wu, Jianzhang, Yali Zhang, Yuepiao Cai, et al. "Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents." Bioorganic & Medicinal Chemistry 21, no. 11 (2013): 3058–65. http://dx.doi.org/10.1016/j.bmc.2013.03.057.

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13

Liu, Zhiguo, Longguang Tang, Peng Zou, et al. "Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents." European Journal of Medicinal Chemistry 74 (March 2014): 671–82. http://dx.doi.org/10.1016/j.ejmech.2013.10.061.

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14

Liu, Xue-Feng, Qi Wang, Jia-Fang Zheng, et al. "Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms." Free Radical Biology and Medicine 186 (June 2022): 66–75. http://dx.doi.org/10.1016/j.freeradbiomed.2022.05.009.

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15

Wiji Prasetyaningrum, Pekik, Anton Bahtiar, and Hayun Hayun. "Synthesis and Cytotoxicity Evaluation of Novel Asymmetrical Mono-Carbonyl Analogs of Curcumin (AMACs) against Vero, HeLa, and MCF7 Cell Lines." Scientia Pharmaceutica 86, no. 2 (2018): 25. http://dx.doi.org/10.3390/scipharm86020025.

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16

Han, Haoyi, Ali Mohammed Mohammed Alsayed, Yi Wang та ін. "Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway". Bioorganic Chemistry 132 (березень 2023): 106358. http://dx.doi.org/10.1016/j.bioorg.2023.106358.

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17

Chen, Xi, Peiqin Zhang, Huating Zhang, et al. "Discovery of cinnamylaldehyde-derived mono-carbonyl curcumin analogs as anti-gastric cancer agents via suppression of STAT3 and AKT pathway." Bioorganic Chemistry 146 (May 2024): 107306. http://dx.doi.org/10.1016/j.bioorg.2024.107306.

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18

Dong, Lili, Suqing Zheng, Yali Zhang, et al. "Design, synthesis, and evaluation of semi-conservative mono-carbonyl analogs of curcumin as anti-inflammatory agents against lipopolysaccharide-induced acute lung injury." MedChemComm 6, no. 8 (2015): 1544–53. http://dx.doi.org/10.1039/c5md00113g.

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19

Dong, Lili, Suqing Zheng, Yali Zhang, et al. "Correction: Design, synthesis, and evaluation of semi-conservative mono-carbonyl analogs of curcumin as anti-inflammatory agents against lipopolysaccharide-induced acute lung injury." Med. Chem. Commun. 6, no. 9 (2015): 1698. http://dx.doi.org/10.1039/c5md90036k.

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20

Rahmawati, Ismi, and Desi Purwaningsih. "UJI AKTIVITAS ANTIJAMUR BEBERAPA SENYAWA MONOKARBONIL ANALOG CURCUMIN HASIL SINTESIS." Jurnal Bioteknologi & Biosains Indonesia (JBBI) 5, no. 2 (2018): 149. http://dx.doi.org/10.29122/jbbi.v5i2.2835.

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Antifungal Activity of Some Synthesized Mono-Carbonyl Analogue Compounds of CurcuminABSTRACTFungal resistance can pose a threat to future fungal infections, therefore studies to find other compounds that have antifungal activity need to be done. The aim of this study was to examine antifungal activity of synthesized curcumin analogue compounds i.e. 2,6-Bis-(2'-furilidin)-cyclohexanone (26FuH); 2,5-Bis-(2'-furilidine)-cyclopentanone (25FuP) and 1,5-Difuril-1,4-pentadien-3-on (15FuA). The curcumin analogue compound was successfully synthesized with Aldol condensation using KOH 7.5% as the cataly

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21

Sowa-Kasprzak, Katarzyna, Dorota Olender, Jacek Kujawski, Lucjusz Zaprutko, and Anna Pawełczyk. "Synthesis of curcumin derivatives containing non-steroidal anti-inflammatory drugs." Acta Poloniae Pharmaceutica - Drug Research 80, no. 2 (2023): 289–304. http://dx.doi.org/10.32383/appdr/161972.

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Synthesis and biological evaluation of hybrid molecules combining naturally occurring antioxidant active structures with anti-inflammatory agents has been a strong trend in medicinal chemistry. This study focuses on modulating the structure of curcumin derivatives or their analogues with the use of non-steroidal anti-inflammatory drugs (NSAIDs). The combinations of curcumin, its keto-blocked derivatives and monocarbonyl analogues with selected non-steroidal anti-inflammatory drugs (ibuprofen, naproxen) were obtained and characterized. The pyrazole, isoxazole, benzylidene derivatives as well as

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22

Liu, Xuefeng, Hongmei Cui, Mi Li, et al. "Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition." European Journal of Medicinal Chemistry 250 (March 2023): 115191. http://dx.doi.org/10.1016/j.ejmech.2023.115191.

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23

Zhu, Heping, Tingting Xu, Chenyu Qiu, et al. "Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats." European Journal of Medicinal Chemistry 121 (October 2016): 181–93. http://dx.doi.org/10.1016/j.ejmech.2016.05.041.

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24

Wijianto, Bambang, Ritmaleni, Hari Purnomo, and Arief Nurrochmad. "Quantitative structure activity relationship (qsar) study and biological evaluation on mono-ketone analogs of curcumin as antioxidant." Research Journal of Pharmacy and Technology 13, no. 10 (2020): 4829. http://dx.doi.org/10.5958/0974-360x.2020.00850.1.

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25

Liang, Baoxia, Ziyi Liu, Yingnan Cao, et al. "MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells." European Journal of Pharmacology 796 (February 2017): 139–48. http://dx.doi.org/10.1016/j.ejphar.2016.12.030.

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26

Jessica, Maria Anabella, Tutuk Budiati, and Caroline. "Pengaruh Gugus Hidroksi pada Sintesis Senyawa 4,4’-Dihidroksibenzalaseton dan Aktivitasnya sebagai Antioksidan." Jurnal Farmasi Sains dan Terapan 12, no. 1 (2025): 54–63. https://doi.org/10.33508/jfst.v12i1.7201.

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Dibenzalacetone and their derivatives, , 4,4’ dihydroxydibenzalacetone are curcumin analogs that have antioxidant activity. The effect of hydroxyl group on the synthesis reaction is proven by comparing the synthesis results yield of dibenzalacetone with 4,4’-dihydroxydibenzalacetone. Both compounds are synthesized through the Claisen-Schmidt condensation reaction using sodium hydroxide as the catalyst. The synthesis results were tested for purity by melting point tests and thin layer chromatography, and structure identification tests were carried out using infrared spectrophotometry. The resul

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27

Dai, Xuanxuan, Junru Zhang, Guilong Guo, et al. "A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction." Cancer Management and Research Volume 10 (August 2018): 3069–82. http://dx.doi.org/10.2147/cmar.s159660.

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28

Qian, Jianchang, Xianxin Chen, Sheng Shu, et al. "Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI)." European Journal of Medicinal Chemistry 167 (April 2019): 414–25. http://dx.doi.org/10.1016/j.ejmech.2019.02.042.

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29

Zhao, Chengguang, Zhiguo Liu, and Guang Liang. "Promising Curcumin-based Drug Design: Mono-carbonyl Analogues of Curcumin (MACs)." Current Pharmaceutical Design 19, no. 11 (2013): 2114–35. http://dx.doi.org/10.2174/1381612811319110012.

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30

Zhao, Chengguang, Zhiguo Liu, and Guang Liang. "Promising Curcumin-based Drug Design: Mono-carbonyl Analogues of Curcumin (MACs)." Current Pharmaceutical Design 19, no. 11 (2013): 2114–35. http://dx.doi.org/10.2174/138161213805289282.

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31

Chapurkin, V. V., and S. V. Chapurkin. "SYNTHESIS POLYFLUORINE-CONTAINING OF MONO-, DI- , TRIPEROXIDES." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 5(252) (May 28, 2021): 11–14. http://dx.doi.org/10.35211/1990-5297-2021-5-252-11-14.

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During interaction aliphatic and aromatic fluorine-containing carbonyl compounds with hydrope-roxide tret-bytil 1- hydroxylperoxides is obtained, hydrocarbonic analogs of which, mainly are not unstable. Possibility of their extraction and further chemical transformation are discussing.

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32

Cao, Weiya, Pan Yu, Shilong Yang, et al. "Discovery of Novel Mono-Carbonyl Curcumin Derivatives as Potential Anti-Hepatoma Agents." Molecules 28, no. 19 (2023): 6796. http://dx.doi.org/10.3390/molecules28196796.

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Curcumin possesses a wide spectrum of liver cancer inhibition effects, yet it has chemical instability and poor metabolic properties as a drug candidate. To alleviate these problems, a series of new mono-carbonyl curcumin derivatives G1–G7 were designed, synthesized, and evaluated by in vitro and in vivo studies. Compound G2 was found to be the most potent derivative (IC50 = 15.39 μM) compared to curcumin (IC50 = 40.56 μM) by anti-proliferation assay. Subsequently, molecular docking, wound healing, transwell, JC-1 staining, and Western blotting experiments were performed, and it was found that

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33

Yin, Song, Xing Zheng, Xu Yao, Yuhong Wang, and Duanfang Liao. "Synthesis and Anticancer Activity of Mono-Carbonyl Analogues of Curcumin." Journal of Cancer Therapy 04, no. 01 (2013): 113–23. http://dx.doi.org/10.4236/jct.2013.41016.

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34

Lin, Han, Guo-Xin Hu, Jingjing Guo та ін. "Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors". Bioorganic & Medicinal Chemistry Letters 23, № 15 (2013): 4362–66. http://dx.doi.org/10.1016/j.bmcl.2013.05.080.

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35

Almayyahi, Muhanad T., Basil A. Saleh, and Baqer A. Almayyahi. "Synthesis and Characterization of Some New Copolyester from Curcumin Mono-Carbonyl Analogues." Biomedicine and Chemical Sciences 3, no. 1 (2022): 147–59. http://dx.doi.org/10.48112/bcs.v1i3.179.

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Nine copolyesters were prepared from a dicarboxylic acid, curcumin analogues (monocarbonyl) and phenophthalene dye in the mole ratio of 2:1:1 by direct polycondensation using triethylamine (Et3N) as the condensation agent. The dicarboxylic used is 2,6-Pyridine dicarbonyl dichloride acid. The curcumin analogues were prepared by acid catalyzed Aldol condensation reaction. These copolyesters were characterized by FT-IR. The fluorescence of the synthesized copolyesters was also investigated. Furthermore, Thermo gravimetric analysis (TGA) was used to investigate the thermal stability of these copol

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36

Hussain, Haya, Shujaat Ahmad, Syed Wadood Ali Shah, et al. "Synthetic Mono-Carbonyl Curcumin Analogues Attenuate Oxidative Stress in Mouse Models." Biomedicines 10, no. 10 (2022): 2597. http://dx.doi.org/10.3390/biomedicines10102597.

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Alzheimer’s disease is the commonest form of dementia associated with short-term memory loss and impaired cognition and, worldwide, it is a growing health issue. A number of therapeutic strategies have been studied to design and develop an effective anti-Alzheimer drug. Curcumin has a wide spectrum of biological properties. In this regard, the antioxidant potentials of mono-carbonyl curcumin analogues (h1–h5) were investigated using in vitro antioxidant assays and hippocampal-based in vivo mouse models such as light–dark box, hole board, and Y-maze tests. In the in vitro assay, mono-carbonyl c

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37

SUN, Li, Jin LIU, Sen-Sen LIN, et al. "Potent anti-angiogenicactivity of B19—a mono-carbonyl analogue of curcumin." Chinese Journal of Natural Medicines 12, no. 1 (2014): 8–14. http://dx.doi.org/10.1016/s1875-5364(14)60002-9.

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38

Liang, Guang, Xiaokun Li, Li Chen, et al. "Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin." Bioorganic & Medicinal Chemistry Letters 18, no. 4 (2008): 1525–29. http://dx.doi.org/10.1016/j.bmcl.2007.12.068.

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39

Liang, Guang, Shulin Yang, Lijuan Jiang, et al. "Synthesis and Anti-bacterial Properties of Mono-carbonyl Analogues of Curcumin." CHEMICAL & PHARMACEUTICAL BULLETIN 56, no. 2 (2008): 162–67. http://dx.doi.org/10.1248/cpb.56.162.

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40

Nagargoje, Amol A., Satish V. Akolkar, Mubarak H. Shaikh, et al. "Investigation of the Anti-inflammatory potential of Mono-carbonyl Analogues of Curcumin." Analytical Chemistry Letters 12, no. 5 (2022): 586–98. http://dx.doi.org/10.1080/22297928.2022.2132877.

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41

Yin, Song, Xing Zheng, Xu Yao, Yuhong Wang, and Duanfang Liao. "ChemInform Abstract: Synthesis and Anticancer Activity of Mono-Carbonyl Analogues of Curcumin." ChemInform 45, no. 41 (2014): no. http://dx.doi.org/10.1002/chin.201441243.

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42

Wu, Jianzhang, Bixia Weng, Peihong Qiu, et al. "Synthesis, Crystal Structure, Antitumor Activity of Spiro-heterocyclic Mono-carbonyl Analogues of Curcumin." Chinese Journal of Organic Chemistry 34, no. 8 (2014): 1573. http://dx.doi.org/10.6023/cjoc201402004.

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43

Rayanal, Manjula, Prasad Pralhad Pujar, and Sridhar D. "Studies on Photophysical Properties of Mono-carbonyl Curcumin Analogues: Experimental and Theoretical approach." Oriental Journal of Chemistry 34, no. 4 (2018): 2170–79. http://dx.doi.org/10.13005/ojc/3404059.

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The solvatochromic fluorescence behaviour of mono-carbonyl curcumin analogues has been studied in ten different solvents ranging from non-polar to polar. The solvent effect on the spectral properties of analogues has been discussed. The ground state dipole moments were estimated experimentally by Bilot-Kawski equation which is a function of Stokes shift with the solvent polarity parameters and Guggenheim method and theoretically by TD-DFT studies. The excited state dipole moment was determined using Bilot-Kawski equations. The excited state dipole moments for the two molecules were found to be

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44

Muhanad T. Almayyahi, Basil A. Saleh, and Baqer A. Almayyahi. "Synthesis, Characterization and Thermal Study of Some new Copolyesters from mono-carbonyl analogues of Curcumin and Thymol blue dye." Journal of Kufa for Chemical Sciences 2, no. 9 (2023): 569–81. http://dx.doi.org/10.36329/jkcm/2022/v2.i9.13322.

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A series of copolyesters were prepared from a dicarboxylic acid, curcumin analogues (monocarbonyl) and thymol blue dye in the mole ratio of 2:1:1 by direct polycondensation using triethylamine (Et3N) as the condensation agent. The dicarboxylic used is 2,6-Pyridine dicarbonyl dichloride acid. The curcumin analogues were prepared by acid catalyzed Aldol condensation reaction. These copolyesters were characterized by FT-IR. The fluorescence of the synthesized copolyesters was also investigated. Furthermore, Thermo gravimetric analysis (TGA) was used to investigate the thermal stability of these c

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45

Weng, Qiaoyou, Lili Fu, Gaozhi Chen, et al. "Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin." European Journal of Medicinal Chemistry 103 (October 2015): 44–55. http://dx.doi.org/10.1016/j.ejmech.2015.08.036.

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46

Zhao, Ya, Zhiwei Zheng, Menghan Zhang, et al. "Design, synthesis, and evaluation of mono‐carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis." Journal of Periodontal Research 56, no. 4 (2021): 656–66. http://dx.doi.org/10.1111/jre.12862.

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47

Liang, Guang, Huiping Zhou, Yi Wang, et al. "Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin." Journal of Cellular and Molecular Medicine 13, no. 9b (2009): 3370–79. http://dx.doi.org/10.1111/j.1582-4934.2009.00711.x.

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48

Qiu, Chenyu, Yan Hu, Ke Wu, et al. "Synthesis and biological evaluation of allylated mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents for cholangiocarcinoma." Bioorganic & Medicinal Chemistry Letters 26, no. 24 (2016): 5971–76. http://dx.doi.org/10.1016/j.bmcl.2016.10.080.

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Liu, Guo-Yun, Qiang Zhai, Jia-Zhuang Chen, Zhuo-Qing Zhang, and Jie Yang. "2,2′-Fluorine mono-carbonyl curcumin induce reactive oxygen species-Mediated apoptosis in Human lung cancer NCI-H460 cells." European Journal of Pharmacology 786 (September 2016): 161–68. http://dx.doi.org/10.1016/j.ejphar.2016.06.009.

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Zhao, Chengguang, Yuepiao Cai, Xuzhi He, et al. "Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages." European Journal of Medicinal Chemistry 45, no. 12 (2010): 5773–80. http://dx.doi.org/10.1016/j.ejmech.2010.09.037.

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