Academic literature on the topic 'Morris wate maze behaviour paradigm'

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Journal articles on the topic "Morris wate maze behaviour paradigm"

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Ekwutosi Patricia, Chinwuba, Bakare Adewale Ganiyu, Ben-Azu Benneth, and Iwalewa Ezekiel Olugbenga. "Evaluation of the Memory Enhancing Activity of Dichloromethane Fraction of the Methanolic Extract of Pycnanthus angolensis Stem Bark on Experimental Models of Memory Impairment." Drug Research 69, no. 10 (2019): 551–58. http://dx.doi.org/10.1055/a-0875-3631.

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Abstract Pycnanthus angolensis (Welw) Warb., Myristicaceae, is used extensively in ethnomedicine. Numerous health benefits have been ascribed to the use of different parts of P. angolensis including its role in cognitive function and inflammatory conditions. Hence, this study was undertaken to investigate the effect of stem bark of the plant on memory function in mice.The plant material was pulverized into powder and extracted by maceration with 80% methanol at room temperature for 48 h. This was subsequently fractionated using N-hexane, Dichloromethane (DCM) and Ethyl acetate. The Dichloromet
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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Richard E. Brown, and Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies." F1000Research 8 (August 28, 2019): 1521. http://dx.doi.org/10.12688/f1000research.20352.1.

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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies hav
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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Ricky Ma, Richard E. Brown, and Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies." F1000Research 8 (June 15, 2020): 1521. http://dx.doi.org/10.12688/f1000research.20352.2.

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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies hav
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Venkataramaiah, Ch, G. Swathi, and W. Rajendra. "MORRIS WATER MAZE – A BENCH MARK TEST FOR LEARNING AND MEMORY DISORDERS IN ANIMAL MODELS: A REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 25. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24292.

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The morris water maze (MWM) was developed by morris as a device to investigate spatial learning and memory in laboratory rats. MWM has become one of the most frequently used laboratory tools in behavioral neuroscience. The MWM task has been often used in the validation of rodent models for neurocognitive disorders (e.g., Parkinson, Alzheimer, Epilepsy, and Schizophrenia), and the evaluation of possible neurocognitive treatments. It is also being used to assess the properties of established potential antipsychotics in animal models of Schizophrenia. The MWM task requires rats to find a hidden p
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Abderrahim, Laaziz, El Mostafi Hicham, Elhessni Aboubaker, et al. "Sex differences in behavioral, cognitive and voluntary ethanol-intake effects in Dexamethasone-induced depression-like state in Wistar rat." AIMS Neuroscience 9, no. 2 (2022): 228–49. http://dx.doi.org/10.3934/neuroscience.2022012.

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<abstract> <p>The stress response is attached to psychosomatic and psychiatric disorders. Therefore, it is important to comprehend the underlying mechanisms influencing this relationship. Moreover, men and women respond differently to stress–both psychologically and biologically. These differences should be studied to have an enhanced understanding of the gender difference. However, researches shedding light on sex dimorphism implication have historically been insufficient. Based on observations that advocate the inclusion of sex as a biological variable in stress response, the pre
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Imam, Aminu, Nafeesah Abdulkareem Sulaiman, Aboyeji Lukuman Oyewole, et al. "Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats." Toxics 6, no. 4 (2018): 71. http://dx.doi.org/10.3390/toxics6040071.

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The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to a combination of two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP), on neuro-cognitive performance and anxiety-like behaviors in rats. Thirty-two adult male Wistar rats (150–170 g) were randomly divided into four groups, orally
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Giménez-Llort, Lydia, Mikel Santana-Santana, Míriam Ratia, et al. "Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3." Brain Sciences 11, no. 4 (2021): 426. http://dx.doi.org/10.3390/brainsci11040426.

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A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer’s disease (AD) pathologies. Sundowning behavior is a common neuropsychiatric symptom (NPS) associated with dementia. Sleep fragmentation resulting from disturbances in sleep and circadian rhythms in AD may have important consequences on memory processes and exacerbate the other AD-NPS. The present work studied the effect of training time schedules on 12-month-old male 3xTg-AD mice modeling advanced disease stages. Their performance in two para
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Rafi, Hira, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, and Muhammad Farhan. "Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl3 and Forced Swim Stress." Current Clinical Pharmacology 15, no. 3 (2020): 251–64. http://dx.doi.org/10.2174/1574884714666191016152143.

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Aim: Endogenous agmatine has a significant role in learning and memory processes as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during the learning process in the rat brain. Dietary intake of choline showed correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias. Methods: 36 Albino rats were equally divided into three groups previously: a) cont
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Andriushchenko, Nika, Kira Nebogina, Yana Zorkina, et al. "Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress." Scientia Pharmaceutica 90, no. 3 (2022): 50. http://dx.doi.org/10.3390/scipharm90030050.

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The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicants for this role. We investigated the antidepressant effect of neuropeptide Y (NY), alone and in combination with clomipramine, in models of acute and chronic stress induced by ultrasound of variable frequencies. Rats were divided into the following groups: the control group, stress group, and stress groups with intranasal administration of NY (100 μg/kg) or clomipramine (7.5 mg/kg), or their combination. Rat behavior was evaluated using a sucrose preference test and forced
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McKay, Leah, Louis Hunninck, and Michael Sheriff. "A Field-Based Adaptation of the Classic Morris Water Maze to Assess Learning and Memory in a Free-Living Animal." Animal Behavior and Cognition 9, no. 4 (2020): 396–407. http://dx.doi.org/10.26451/abc.09.04.03.2022.

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Free-living animals rely on cognitive functions, such as learning and memory, for numerous aspects of their survival. However, research involving these mechanisms is often limited to the laboratory where animals are far removed from natural influences. Here, we adapted the Morris Water Maze (MWM) for use in the field to test learning and memory of free-living white-footed mice, Peromyscus leucopus. The MWM consists of a pool filled with opaque water and a platform that is hidden beneath the surface of the water. Mice were tasked with finding an escape platform using proximate-cue based spatial
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