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Journal articles on the topic 'Morris wate maze behaviour paradigm'

Author: Grafiati

Published: 6 September 2023

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1

Ekwutosi Patricia, Chinwuba, Bakare Adewale Ganiyu, Ben-Azu Benneth, and Iwalewa Ezekiel Olugbenga. "Evaluation of the Memory Enhancing Activity of Dichloromethane Fraction of the Methanolic Extract of Pycnanthus angolensis Stem Bark on Experimental Models of Memory Impairment." Drug Research 69, no. 10 (2019): 551–58. http://dx.doi.org/10.1055/a-0875-3631.

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Abstract Pycnanthus angolensis (Welw) Warb., Myristicaceae, is used extensively in ethnomedicine. Numerous health benefits have been ascribed to the use of different parts of P. angolensis including its role in cognitive function and inflammatory conditions. Hence, this study was undertaken to investigate the effect of stem bark of the plant on memory function in mice.The plant material was pulverized into powder and extracted by maceration with 80% methanol at room temperature for 48 h. This was subsequently fractionated using N-hexane, Dichloromethane (DCM) and Ethyl acetate. The Dichloromet

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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Richard E. Brown, and Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies." F1000Research 8 (August 28, 2019): 1521. http://dx.doi.org/10.12688/f1000research.20352.1.

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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies hav

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Cooke, Matthew B., Timothy P. O'Leary, Phelan Harris, Ricky Ma, Richard E. Brown, and Jason S. Snyder. "Pathfinder: open source software for analyzing spatial navigation search strategies." F1000Research 8 (June 15, 2020): 1521. http://dx.doi.org/10.12688/f1000research.20352.2.

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Spatial navigation is a universal behavior that varies depending on goals, experience and available sensory stimuli. Spatial navigational tasks are routinely used to study learning, memory and goal-directed behavior, in both animals and humans. One popular paradigm for testing spatial memory is the Morris water maze, where subjects learn the location of a hidden platform that offers escape from a pool of water. Researchers typically express learning as a function of the latency to escape, though this reveals little about the underlying navigational strategies. Recently, a number of studies hav

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Venkataramaiah, Ch, G. Swathi, and W. Rajendra. "MORRIS WATER MAZE – A BENCH MARK TEST FOR LEARNING AND MEMORY DISORDERS IN ANIMAL MODELS: A REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 25. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24292.

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The morris water maze (MWM) was developed by morris as a device to investigate spatial learning and memory in laboratory rats. MWM has become one of the most frequently used laboratory tools in behavioral neuroscience. The MWM task has been often used in the validation of rodent models for neurocognitive disorders (e.g., Parkinson, Alzheimer, Epilepsy, and Schizophrenia), and the evaluation of possible neurocognitive treatments. It is also being used to assess the properties of established potential antipsychotics in animal models of Schizophrenia. The MWM task requires rats to find a hidden p

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Abderrahim, Laaziz, El Mostafi Hicham, Elhessni Aboubaker, et al. "Sex differences in behavioral, cognitive and voluntary ethanol-intake effects in Dexamethasone-induced depression-like state in Wistar rat." AIMS Neuroscience 9, no. 2 (2022): 228–49. http://dx.doi.org/10.3934/neuroscience.2022012.

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<abstract> <p>The stress response is attached to psychosomatic and psychiatric disorders. Therefore, it is important to comprehend the underlying mechanisms influencing this relationship. Moreover, men and women respond differently to stress–both psychologically and biologically. These differences should be studied to have an enhanced understanding of the gender difference. However, researches shedding light on sex dimorphism implication have historically been insufficient. Based on observations that advocate the inclusion of sex as a biological variable in stress response, the pre

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Imam, Aminu, Nafeesah Abdulkareem Sulaiman, Aboyeji Lukuman Oyewole, et al. "Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats." Toxics 6, no. 4 (2018): 71. http://dx.doi.org/10.3390/toxics6040071.

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The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to a combination of two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP), on neuro-cognitive performance and anxiety-like behaviors in rats. Thirty-two adult male Wistar rats (150–170 g) were randomly divided into four groups, orally

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Giménez-Llort, Lydia, Mikel Santana-Santana, Míriam Ratia, et al. "Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3." Brain Sciences 11, no. 4 (2021): 426. http://dx.doi.org/10.3390/brainsci11040426.

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A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer’s disease (AD) pathologies. Sundowning behavior is a common neuropsychiatric symptom (NPS) associated with dementia. Sleep fragmentation resulting from disturbances in sleep and circadian rhythms in AD may have important consequences on memory processes and exacerbate the other AD-NPS. The present work studied the effect of training time schedules on 12-month-old male 3xTg-AD mice modeling advanced disease stages. Their performance in two para

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Rafi, Hira, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq, and Muhammad Farhan. "Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl3 and Forced Swim Stress." Current Clinical Pharmacology 15, no. 3 (2020): 251–64. http://dx.doi.org/10.2174/1574884714666191016152143.

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Aim: Endogenous agmatine has a significant role in learning and memory processes as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during the learning process in the rat brain. Dietary intake of choline showed correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias. Methods: 36 Albino rats were equally divided into three groups previously: a) cont

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Andriushchenko, Nika, Kira Nebogina, Yana Zorkina, et al. "Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress." Scientia Pharmaceutica 90, no. 3 (2022): 50. http://dx.doi.org/10.3390/scipharm90030050.

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The search for potential effective antidepressants with minimal side effects is necessary. Peptides are possible applicants for this role. We investigated the antidepressant effect of neuropeptide Y (NY), alone and in combination with clomipramine, in models of acute and chronic stress induced by ultrasound of variable frequencies. Rats were divided into the following groups: the control group, stress group, and stress groups with intranasal administration of NY (100 μg/kg) or clomipramine (7.5 mg/kg), or their combination. Rat behavior was evaluated using a sucrose preference test and forced

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McKay, Leah, Louis Hunninck, and Michael Sheriff. "A Field-Based Adaptation of the Classic Morris Water Maze to Assess Learning and Memory in a Free-Living Animal." Animal Behavior and Cognition 9, no. 4 (2020): 396–407. http://dx.doi.org/10.26451/abc.09.04.03.2022.

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Free-living animals rely on cognitive functions, such as learning and memory, for numerous aspects of their survival. However, research involving these mechanisms is often limited to the laboratory where animals are far removed from natural influences. Here, we adapted the Morris Water Maze (MWM) for use in the field to test learning and memory of free-living white-footed mice, Peromyscus leucopus. The MWM consists of a pool filled with opaque water and a platform that is hidden beneath the surface of the water. Mice were tasked with finding an escape platform using proximate-cue based spatial

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Graham, Martha A., Patria T. Juzang, and Todd E. White. "Effects of repetitive mild traumatic brain injury on weight gain and chronic behavioral outcomes in male rats." PLOS ONE 18, no. 7 (2023): e0287506. http://dx.doi.org/10.1371/journal.pone.0287506.

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To assess the long-term behavioral effects of repetitive mild traumatic brain injury (rmTBI), we employed a preclinical model of rmTBI and performed a battery of behavioral tests starting 14 weeks post-injury. Male Sprague-Dawley rats received four unilateral mild (6 m/s; 0.5 mm depth) controlled cortical impacts (CCI), centered 4 mm posterior and 3–4 mm lateral to the bregma, administered at five-day intervals. The animals’ weights were monitored throughout the study. We tested the rats for anxiety-like (elevated plus maze, open field test), depression-like (forced swim test), locomotor (rota

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Hoffman, Jay R., Amitai Zuckerman, Omri Ram, Oren Sadot, and Hagit Cohen. "Changes in Hippocampal Androgen Receptor Density and Behavior in Sprague-Dawley Male Rats Exposed to a Low-Pressure Blast Wave." Brain Plasticity 5, no. 2 (2020): 135–45. http://dx.doi.org/10.3233/bpl-200107.

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Objective: The purpose of this study was to examine the effect of exposure of a low-intensity blast wave on androgen receptor (AR) density in the hippocampus and the potential influence on behavioral and cognitive responses. Methods: Sprague-Dawley rats were randomly assigned to either a blast exposed group (n = 27) or an unexposed (control) group (n = 10). Animals were treated identically, except that rats within the control group were not exposed to any of the characteristics of the blast wave. Behavior measures were conducted on day seven post-exposure. The rats were initially assessed in t

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Wang, Fuhu, Dale Corbett, Hitoshi Osuga, et al. "Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat." Journal of Cerebral Blood Flow & Metabolism 22, no. 2 (2002): 171–82. http://dx.doi.org/10.1097/00004647-200202000-00005.

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Increasing evidence suggests that cyclin-dependent kinases participate in neuronal death induced by multiple stresses in vitro. However, their role in cell death paradigms in vivo is not well characterized. Accordingly, the authors examined whether cyclin-dependent kinase inhibition resulted in functionally relevant and sustained neuroprotection in a model of global ischemia. Intracerebroventricular administration of the cyclin-dependent kinase inhibitor flavopiridol, immediately or at 4 hours postreperfusion after a global insult, reduced injury in the CA1 of the hippocampus when examined 7 d

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Segar, Jeffrey L., Connie C. Grobe, Kirthikaa Balapattabi, McKenzie L. Ritter, John J. Reho, and Justin L. Grobe. "Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320, no. 4 (2021): R438—R451. http://dx.doi.org/10.1152/ajpregu.00281.2020.

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Postnatal growth failure is a common morbidity for preterm infants and is associated with adverse neurodevelopmental outcomes. Although sodium (Na) deficiency early in life impairs somatic growth, its impact on neurocognitive functions has not been extensively studied. We hypothesized that Na deficiency during early life is sufficient to cause growth failure and program neurobehavioral impairments in later life. C57BL/6J mice were placed on low- (0.4), normal- (1.5), or high- (3 g/kg) Na chow at weaning ( PD22) and continued on the diet for 3 wk (to PD40). Body composition and fluid distributi

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Es-safi, Imane, Hamza Mechchate, Amal Amaghnouje, et al. "Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice." Plants 10, no. 8 (2021): 1573. http://dx.doi.org/10.3390/plants10081573.

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Mental disorders are psychological symptoms that impact multiple areas of an individual’s life. Depression and anxiety are chronic illnesses described as the most prevalent stress-related mood disorders that cause injury and early death. In Morocco, Anise “Pimpinella anisum L.” is one of the most traditionally used condiment plants, which has long been used to cure various illnesses and in phytotherapy. The present study was designed to investigate the antidepressant, anxiolytic, and memory impact of the total extract of Pimpinella anisum (PATE) at the doses of 100 and 200 mg/kg, using the For

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Karunakaran, Smitha. "Unraveling Early Signs of Navigational Impairment in APPswe/PS1dE9 Mice Using Morris Water Maze." Frontiers in Neuroscience 14 (December 15, 2020). http://dx.doi.org/10.3389/fnins.2020.568200.

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Mild behavioral deficits, which are part of normal aging, can be early indicators of an impending Alzheimer's disease. Using the APPswe/PS1dE9 (APP/PS1) mouse model of Alzheimer's disease, we utilized the Morris water maze spatial learning paradigm to systematically evaluate mild behavioral deficits that occur during the early stages of disease pathogenesis. Conventional behavioral analysis using this model indicates that spatial memory is intact at 2 months of age. In this study, we used an alternative method to analyze the behavior of mice, aiming to gain a better understanding of the nature

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Karunakaran, Smitha. "Unraveling Early Signs of Navigational Impairment in APPswe/PS1dE9 Mice Using Morris Water Maze." Frontiers in Neuroscience 14 (December 15, 2020). http://dx.doi.org/10.3389/fnins.2020.568200.

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Mild behavioral deficits, which are part of normal aging, can be early indicators of an impending Alzheimer's disease. Using the APPswe/PS1dE9 (APP/PS1) mouse model of Alzheimer's disease, we utilized the Morris water maze spatial learning paradigm to systematically evaluate mild behavioral deficits that occur during the early stages of disease pathogenesis. Conventional behavioral analysis using this model indicates that spatial memory is intact at 2 months of age. In this study, we used an alternative method to analyze the behavior of mice, aiming to gain a better understanding of the nature

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Dusa, Daniella, Tamás Ollmann, Veronika Kállai, et al. "The antipsychotic drug sulpiride in the ventral pallidum paradoxically impairs learning and induces place preference." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-23450-z.

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AbstractSulpiride, as a D2-like dopamine (DA) receptor (D2R) antagonist, is an important antipsychotic drug in the treatment of schizophrenia. Recently, we have shown that the activation of D2Rs in the ventral pallidum (VP) modulates the activity of the ventral tegmental area (VTA) DAergic neurons. According to our hypothesis, intra-VP sulpiride can influence the motivational and learning processes, pervasively modifying the behavior of examined animals. In the present study, sulpiride was microinjected into the VP of male Wistar rats in three different doses. Morris water maze (MWM) test was

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Zhang, Wenying, Tingyu Ding, Hong Zhang, et al. "Clostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1." Frontiers in Pharmacology 13 (April 6, 2022). http://dx.doi.org/10.3389/fphar.2022.845221.

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Recent investigations have demonstrated that the chronic stress-induced behavioral disorders can be ameliorated by probiotics including Clostridium butyricum (C. butyricum) via the gut-brain-axis. However, the molecular mechanisms underlying the beneficial effects of C. butyricum on brain remain largely unknown. Here, we investigated whether chronic foot shock stress (CFSS) paradigm used for a hypertensive animal model could induce mood disorders such as anxiety, depression and cognitive impairments. Then, we assessed the impact of C. butyricum RH2 on the behavior disorders and neurobiological

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Matthews, Douglas B., Samantha Scaletty, Sarah Trapp, et al. "Chronic intermittent ethanol exposure during adolescence produces sex- and age-dependent changes in anxiety and cognition without changes in microglia reactivity late in life." Frontiers in Behavioral Neuroscience 17 (August 1, 2023). http://dx.doi.org/10.3389/fnbeh.2023.1223883.

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Binge-like ethanol exposure during adolescence has been shown to produce long lasting effects in animal models including anxiety-like behavior that can last into young adulthood and impairments in cognition that can last throughout most of the lifespan. However, little research has investigated if binge-like ethanol exposure during adolescence produces persistent anxiety-like behavior and concomitantly impairs cognition late in life. Furthermore, few studies have investigated such behavioral effects in both female and male rats over the lifespan. Finally, it is yet to be determined if binge-li

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Ahmed, Touqeer, Sara Ishaq, Sohana Siyar, Rabia Basri, Amna Liaqat, and Armeen Hameed. "Neuroprotective effects of Shogaol in metals (Al, As and Pb) and high fat diet induced neuroinflammation and behavior in mice." Current Molecular Pharmacology 15 (September 28, 2022). http://dx.doi.org/10.2174/1874467215666220928110557.

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Background: Increased exposure of humans to toxic metals and high fat diet (HFD) consumption severely damages brain health. Natural plant extracts have shown huge potential to treat multiple human diseases. Objective: The present study was designed to evaluate the protective effects of Shogaol (an active component of ginger) in neuroinflammation and behavioral paradigms in mice treated with metals and HFD. Methods: 8-11 weeks old male mice model was developed by giving a combination of metals i.e. Arsenic (As), Lead (Pb) and Aluminum (Al), 25mg/kg each mixed in drinking water with laboratory p

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Wang, H.-N., Y. Peng, Q.-R. Tan, et al. "Quetiapine Ameliorates Anxiety-Like Behavior and Cognitive Impairments in Stressed Rats: Implications for the Treatment of Posttraumatic Stress Disorder." Physiological Research, 2010, 263–71. http://dx.doi.org/10.33549/physiolres.931756.

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The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electri

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Diekmann, Nicolas, Sandhiya Vijayabaskaran, Xiangshuai Zeng, David Kappel, Matheus Chaves Menezes, and Sen Cheng. "CoBeL-RL: A neuroscience-oriented simulation framework for complex behavior and learning." Frontiers in Neuroinformatics 17 (March 9, 2023). http://dx.doi.org/10.3389/fninf.2023.1134405.

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Reinforcement learning (RL) has become a popular paradigm for modeling animal behavior, analyzing neuronal representations, and studying their emergence during learning. This development has been fueled by advances in understanding the role of RL in both the brain and artificial intelligence. However, while in machine learning a set of tools and standardized benchmarks facilitate the development of new methods and their comparison to existing ones, in neuroscience, the software infrastructure is much more fragmented. Even if sharing theoretical principles, computational studies rarely share so

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Gupta, Surbhi, and Bhupesh Sharma. "Neuroprotective potential of Cilostazol in 3-NP provoked Huntington's disease-associated symptoms." Research Journal of Pharmacy and Technology, May 2021, 2472–78. http://dx.doi.org/10.52711/0974-360x.2021.00435.

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Huntington's disease (HD), a neurodegenerative condition specified by mitochondrial deficits, psychiatric and cognitive impairment developed due to neuronal damage in the brain. 3-nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase develops behavioral, biochemical as well as histological alterations in the striatal region of brain, which resembles HD in humans. Phosphodiesterases (PDEs) participate in cognition, motor functions, and behavior as well as also offers neuroprotection. The present investigation was framed to analyze the neuro-defensive characteristics of cilostazol

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Wei, Ru-Meng, Yue-Ming Zhang, Yun Li, et al. "Altered cognition and anxiety in adolescent offspring whose mothers underwent different-pattern maternal sleep deprivation, and cognition link to hippocampal expressions of Bdnf and Syt-1." Frontiers in Behavioral Neuroscience 16 (December 8, 2022). http://dx.doi.org/10.3389/fnbeh.2022.1066725.

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BackgroundInadequate sleep during pregnancy negatively affects the neural development of offspring. Previous studies have focused on the continuous sleep deprivation (CSD) paradigm, but the sleep pattern during late pregnancy is usually fragmented.ObjectiveTo compare the effects of CSD and fragmented sleep deprivation (FSD) in late pregnancy on emotion, cognition, and expression of synaptic plasticity-related proteins in offspring mice.MethodsPregnant CD-1 mice were either subjected to 3/6 h of CSD/FSD during gestation days 15–21, while those in the control group were left untreated. After del

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Amelchenko, Evgeny M., Dmitri V. Bezriadnov, Olga A. Chekhov, et al. "Cognitive flexibility is selectively impaired by radiation and is associated with differential recruitment of adult-born neurons." Journal of Neuroscience, August 2, 2023, JN—RM—0161–22. http://dx.doi.org/10.1523/jneurosci.0161-22.2023.

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Exposure to elevated doses of ionizing radiation, such as those in therapeutic procedures, catastrophic accidents, or space exploration, increases the risk of cognitive dysfunction. The full range of radiation-induced cognitive deficits is unknown, partly because commonly used tests may be insufficiently sensitive or may not be adequately tuned for assessing the fine behavioral features affected by radiation. Here, we asked whether gamma-radiation might affect learning, memory, and the overall ability to adapt behavior to cope with a challenging environment (cognitive/behavioral flexibility).

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Wang, Xiaotian, Xue Wang, Fang Xie, et al. "Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy." Frontiers in Cellular Neuroscience 16 (January 4, 2023). http://dx.doi.org/10.3389/fncel.2022.1060712.

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ObjectivesTo explore the relationship between leucine in cerebrospinal fluid (CSF) and cognitive dysfunction in rats with early life stress (ELS) induced mental illness, and pathophysiological mechanism involved.MethodsThe maternal separation (MS), an animal paradigm used widely as a preclinical model of ELS which is one of the important risk factors for mental disorders. Behavioral experiments including open-field test, sucrose preference, object recognition and Morris water maze tests, Nissl staining, transmission electron microscopy and WES were employed in the present study.ResultsThe beha

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Gáspár, Attila, Barbara Hutka, Aliz Judit Ernyey, et al. "Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-24292-5.

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AbstractThe intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats. We postulate that the translationally most relevant animal population of an AD model should be that of aged rats with substantial learning history. The objective of the study was thus to probe the model in old rats with knowledge in various cognitive domains. Long-Evans rats of 23 and 10 months age with acquired knowledge in five-choice serial reaction time task (5-CSRTT), a cooper

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Lambert, Anthony. "Rainbow Blindness: Same-Sex Partnerships in Post-Coalitional Australia." M/C Journal 13, no. 6 (2010). http://dx.doi.org/10.5204/mcj.318.

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In Australia the “intimacy” of citizenship (Berlant 2), is often used to reinforce subscription to heteronormative romantic and familial structures. Because this framing promotes discourses of moral failure, recent political attention to sexuality and same-sex couples can be filtered through insights into coalitional affiliations. This paper uses contemporary shifts in Australian politics and culture to think through the concept of coalition, and in particular to analyse connections between sexuality and governmentality (or more specifically normative bias and same-sex relationships) in what I

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