Relevant bibliographies by topics / MTOR

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'MTOR'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "MTOR"

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López, Esther, Alejandro Berna-Erro, Javier J. López, et al. "Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology." Thrombosis and Haemostasis 114, no. 11 (2015): 969–81. http://dx.doi.org/10.1160/th14-09-0727.

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SummaryThe function of the mammalian target of rapamycin (mTOR) is upregulated in response to cell stimulation with growing and differentiating factors. Active mTOR controls cell proliferation, differentiation and death. Since mTOR associates with different proteins to form two functional macromolecular complexes, we aimed to investigate the role of the mTORI and mTOR2 complexes in MEG-01 cell physiology in response to thrombopoietin (TPO). By using mTOR antagonists and overexpressing FKBP38, we have explored the role of both mTOR complexes in proliferation, apoptosis, maturation-like mechanis
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Białoń, Natalia, Krzysztof Suszyński, Mikołaj Górka, et al. "Szlak mTOR i zwierzęta transgeniczne z delecją genu TSC w procesie regeneracji układu nerwowego i wybranych modelach uszkodzeń nerwu kulszowego." Postępy Biochemii 69, no. 3 (2023): 159–69. http://dx.doi.org/10.18388/pb.2021_489.

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Urazowe uszkodzenia układu nerwowego od lat są powszechnym zjawiskiem, które obniżają jakość życia pacjentów. Szlak mTOR (ang. mammalian target of rapamycin) pełni kluczową rolę w fizjologii układu nerwowego, między innymi poprzez kontrolę przeżywania i różnicowania komórek nerwowych. Nadmierna aktywacja szlaku mTOR prowadzi do wzrostu aktywności białek cyklu komórkowego i apoptozy komórek nerwowych. Ponadto, aktualne odkrycia sugerują udział szlaku mTOR w neuroplastyczności. Wykorzystanie zwierząt transgenicznych z delecją genu TSC jak i różnych modeli uszkodzeń nerwu kulszowego, pozwala na a
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Wang, Xueyu, Zhiqiang Wei, Yongfang Jiang, Zhongji Meng, and Mengji Lu. "mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication." Virologica Sinica 36, no. 6 (2021): 1303–14. http://dx.doi.org/10.1007/s12250-021-00450-3.

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AbstractMammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that includes mTOR complex (mTORC) 1 and mTORC2. The mTOR pathway is activated in viral hepatitis, including hepatitis B virus (HBV) infection-induced hepatitis. Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the mTOR pathway, indicating that HBV utilizes or hija
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Felkai, Luca, Ildikó Krencz, Dorottya Judit Kiss, et al. "Characterization of mTOR Activity and Metabolic Profile in Pediatric Rhabdomyosarcoma." Cancers 12, no. 7 (2020): 1947. http://dx.doi.org/10.3390/cancers12071947.

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mTOR activation has been observed in rhabdomyosarcoma (RMS); however, mTOR complex (mTORC) 1 inhibition has had limited success thus far. mTOR activation alters the metabolic pathways, which is linked to survival and metastasis. These pathways have not been thoroughly analyzed in RMSs. We performed immunohistochemistry on 65 samples to analyze the expression of mTOR complexes (pmTOR, pS6, Rictor), and several metabolic enzymes (phosphofructokinase, lactate dehydrogenase-A, β-F1-ATPase, glucose-6-phosphate dehydrogenase, glutaminase). RICTOR amplification, as a potential mechanism of Rictor ove
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Saran, Uttara, Michelangelo Foti, and Jean-François Dufour. "Cellular and molecular effects of the mTOR inhibitor everolimus." Clinical Science 129, no. 10 (2015): 895–914. http://dx.doi.org/10.1042/cs20150149.

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mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its downstream targets, has been reported in various cancers. This has promoted the development of anti-cancer therapies targeting mTOR, namely fungal macrolide rapamycin, a naturally occurring mTOR inhibitor, and its analogues (rapalogues). One such rapalogue, everolimus, has been approved in the clinical treatment of renal and breast cancers. Although results have demonstrated that these mTOR inhibitors are effective in a
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Huo, Yilin, Valentina Iadevaia, and Christopher G. Proud. "Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis." Biochemical Society Transactions 39, no. 2 (2011): 446–50. http://dx.doi.org/10.1042/bst0390446.

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mTOR (mammalian target of rapamycin) forms two distinct types of complex, mTORC (mTOR complex) 1 and 2. Rapamycin inhibits some of the functions of mTORC1, whereas newly developed mTOR kinase inhibitors interfere with the actions of both types of complex. We have explored the effects of rapamycin and mTOR kinase inhibitors on general protein synthesis and, using a new stable isotope-labelling method, the synthesis of specific proteins. In HeLa cells, rapamycin only had a modest effect on total protein synthesis, whereas mTOR kinase inhibitors decreased protein synthesis by approx. 30%. This do
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Todeschini, Letizia, Luca Cristin, Alessandro Martinino, Amelia Mattia, Salvatore Agnes, and Francesco Giovinazzo. "The Role of mTOR Inhibitors after Liver Transplantation for Hepatocellular Carcinoma." Current Oncology 30, no. 6 (2023): 5574–92. http://dx.doi.org/10.3390/curroncol30060421.

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Liver transplantation is a treatment option for nonresectable patients with early-stage HCC, with more significant advantages when Milan criteria are fulfilled. An immunosuppressive regimen is required to reduce the risk of graft rejection after transplantation, and CNIs represent the drugs of choice in this setting. However, their inhibitory effect on T-cell activity accounts for a higher risk of tumour regrowth. mTOR inhibitors (mTORi) have been introduced as an alternative immunosuppressive approach to conventional CNI-based regimens to address both immunosuppression and cancer control. The
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Rivas, Donato A., Ben B. Yaspelkis, John A. Hawley та Sarah J. Lessard. "Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside". Journal of Endocrinology 202, № 3 (2009): 441–51. http://dx.doi.org/10.1677/joe-09-0202.

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The serine/threonine protein kinase, mammalian target of rapamycin (mTOR) is regulated by insulin and nutrient availability and has been proposed to play a central role as a nutrient sensor in skeletal muscle. mTOR associates with its binding partners, raptor and rictor, to form two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) respectively. We have investigated the assembly of mTORC1/2 and the activation of their downstream substrates (i.e. Akt, S6K1) in response to known effectors of mTOR, excess lipid availability and AMP-activated pro
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Rosborough, Brian, Dàlia Raïch-Regué, Benjamin Matta та ін. "Rapamycin-resistant mTORC1 restrains dendritic cell B7-H1 expression that requires IL-1β to enhance regulatory T cell induction (P1349)". Journal of Immunology 190, № 1_Supplement (2013): 63.27. http://dx.doi.org/10.4049/jimmunol.190.supp.63.27.

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Abstract Introduction: The mammalian Target of Rapamycin (mTOR) is a central regulator of dendritic cell (DC) function that performs the catalytic activity of mTOR complex (mTORC)1 and 2. mTORC2 functions independently from mTORC1 and is resistant to inhibition by rapamycin (RAPA); however, mTORC1 has both RAPA-sensitive and -resistant outputs. Our goal was to ascertain the role of RAPA-resistant mTOR in DC. Methods: WT C57BL/6 or B7-H1-/- bone marrow-derived DC were generated with the addition of RAPA or ATP-competitive mTOR inhibitor, which blocks all mTOR signaling. DC lacking rictor, an mT
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Chen, Yu-Li, Han-Wei Lin, Nai-Yun Sun, et al. "mTOR Inhibitors Can Enhance the Anti-Tumor Effects of DNA Vaccines through Modulating Dendritic Cell Function in the Tumor Microenvironment." Cancers 11, no. 5 (2019): 617. http://dx.doi.org/10.3390/cancers11050617.

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The life span of dendritic cells (DCs) can become short following induced activation, which is associated with metabolic transition due to the regulation of mechanistic target of rapamycin (mTOR). The purpose of this study was to investigate the potential of inhibiting mTOR to modulate DC functions for elevating the anti-tumor effects of DNA vaccines. Therefore, the influences of various inhibitors of mTOR (mTORi) on the expressions of DC maturation markers, the abilities of antigen presenting and processing of BMM-derived DCs and the tumor killing effects of E7-specific CD8+ T lymphocytes act
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Dissertations / Theses on the topic "MTOR"

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Olsen, Jessica M. "β-Adrenergic Signalling Through mTOR". Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142169.

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Adrenergic signalling is part of the sympathetic nervous system and is activated upon stimulation by the catecholamines epinephrine and norepinephrine. This regulates heart rate, energy mobilization, digestion and helps to divert blood flow to important organs. Insulin is released to regulate metabolism of carbohydrates, fats and proteins, mainly by taking up glucose from the blood. The insulin and the catecholamine hormone systems are normally working as opposing metabolic regulators and are therefore thought to antagonize each other. One of the major regulators involved in insulin signalling
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Schalm, Stefanie. "Molecular mechanism of mTOR downstream signaling." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/249/index.html.

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Joyce, Claire Lois. "Tumour cell responses to mTOR inhibition." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610245.

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März, Andreas. "A new player in mTOR regulation." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-139523.

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Lee, John Hung. "Altered mTOR signaling in Huntington's Disease." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5547.

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Huntington's Disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT). Despite HTTs ubiquitous expression, there is selective vulnerability in a specific brain region known as the striatum, the cause of which is poorly understood. Here, we provide evidence that impaired striatal mTORC1 activity underlies varied metabolic and degenerative phenotypes in striatal tissues from HD mouse models and patients, and show that further mTORC1 impairment in mouse models, achieved through the knockdown of Rhes, a striatum-enriched mTORC1 activator, exacerbates disease phenotypes. In con
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Ramsbottom, Ben Alan. "Regulation of pol III transcription by mTOR." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438962.

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Pimentel, Gustavo Duarte 1983. "Caracterização da AMPK/mTOR hipotalâmica na anorexia induzida pelo câncer : Characterization of hypothalamic AMPK/mTOR in cancer-induced anorexia." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312747.

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Orientador: Jose Barreto Campello Carvalheira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T11:52:05Z (GMT). No. of bitstreams: 1 Pimentel_GustavoDuarte_D.pdf: 5245849 bytes, checksum: ec5c43602ec0d60564455aae4b1fee3a (MD5) Previous issue date: 2015<br>Resumo: A teoria das doenças geradas por citocinas inflamatórias trouxe ao longo dos anos indícios que o organismo pode produzir citocinas que desempenham respostas biológicas benéficas ou prejudiciais. Com o passar dos anos ficou claro que a inflamação é um mec
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Wong, Jacky Sui Ki. "The Evaluation of Dual PI3K/mTOR Inhibitors as a Superior Alternative to mTOR Inhibitors in Pre-B Acute Lymphoblastic Leukaemia." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13644.

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Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Poor long term survival in adults as well as the bleak outlook for relapsed patients highlights the need for new therapeutic strategies for the treatment of ALL. The major regulators of ALL cell proliferation and survival mediate their effects through the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin. It has been previously shown that the mTOR inhibitor RAD001 extended survival in a non-obese diabetic/severe combined immune deficient (NOD/SCID) mouse xenograft model of ALL. The work presente
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Gulati, Ruhi. "Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353.

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Payne, Sara Lauren. "Small-molecule inhibitors of mTOR and DNA-PK." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627731.

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The phosphatidylinositol-3-kinase related kinase (PIKK) family of proteins consists of five serine-threonine protein kinase members (ATM, ATR, hSMG, DNA-PK and mTOR), each of which have been implicated in the cellular response to DNA damage or cellular stress. Upregulation of the PBKJAKT cell signalling pathway has been demonstrated to be a common driver of malignancy in human cancer. The mammalian target of rapamycin (mTOR) exists in two isoforms, both of which lie within the PBKJAKT pathway and as such are capable of mediating the activity of the signalling pathway. The first reported inhibi
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Books on the topic "MTOR"

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Weichhart, Thomas, ed. mTOR. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-430-8.

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Polunovsky, Vitaly A., and Peter J. Houghton, eds. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-271-1.

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Houghton, Peter J., and V. A. Polunovskiĭ. mTOR pathway and mTOR inhibitors in cancer therapy. Humana Press, 2010.

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Dey, Nandini, Pradip De, and Brian Leyland-Jones, eds. PI3K-mTOR in Cancer and Cancer Therapy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34211-5.

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Mita, Monica, Alain Mita, and Eric K. Rowinsky, eds. mTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer Paris, 2016. http://dx.doi.org/10.1007/978-2-8178-0492-7.

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Transportation, Ontario Ministry of. MTO drainage management manual. Ministry of Transportation, 1995.

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Ontario. Ministry of Transportation. Road User Safety Division, ed. The Official MTO Driver's Handbook. Road User Safety Division, Ministry of Transportation, 2015.

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Associates, R. V. Anderson, and Ontario Ministry of Transportation, eds. MTO drainage management technical guidelines. Highway Design Office, Highway Engineering Division, Ontario Ministry of Transportation, 1989.

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Ontario. Ministry of Transportation. Road User Safety Division. The official MTO motorcycle handbook. Road User Safety Division, Ministry of Transportation of Ontario, 2012.

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Karekin. "Khorhē ew mtir--": Khoher ew hayeatsʻkʻner dprevankʻi masin. [s.n.], 1995.

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Book chapters on the topic "MTOR"

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Robitaille, Aaron M. "mTOR." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_331.

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Gewies, Andreas, Jürgen Ruland, Alexey Kotlyarov, et al. "mTOR." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_331.

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Patel, Nisha R., Michael L. Wong, Anthony E. Dragun, et al. "mTOR Inhibitors." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_751.

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Kubica, Neil, and John Blenis. "mTORC1: A Signaling Integration Node Involved in Cell Growth." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_1.

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Dowling, Ryan J. O., and Nahum Sonenberg. "Downstream of mTOR: Translational Control of Cancer." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_10.

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Larsson, Ola, and Peter B. Bitterman. "Genome-Wide Analysis of Translational Control." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_11.

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Bitterman, Peter B., and Vitaly A. Polunovsky. "Translational Control of Cancer: Implications for Targeted Therapy." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_12.

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Pelletier, Jerry, and Jeremy R. Graff. "Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_13.

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Feng, Zhaohui, and Arnold J. Levine. "The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_2.

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Mead, Henry, Mirjana Zeremski, and Markus Guba. "mTOR Signaling in Angiogenesis." In mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-271-1_3.

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Conference papers on the topic "MTOR"

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Rodrik-Outmezguine, Vanessa S., Masanori Okaniwa, Zhan Yao, et al. "Abstract 2147: Overcoming mTOR resistance mutations with a new generation mTOR inhibitor." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2147.

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Li, Wen-ze, and De-wu Ding. "Network Analysis of mTOR Regulator." In 2012 Sixth International Conference on Internet Computing for Science and Engineering (ICICSE). IEEE, 2012. http://dx.doi.org/10.1109/icicse.2012.26.

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Pereira, Luan Filipe de Souza, KARLA FABIANE LOPES DE MELO, FRANCISCO CANINDÉ FERREIRA DE LUNA, EDNA CRISTINA SANTOS FRANCO, and SAMIR MANSOUR MORAES CASSEB. "ANÁLISE DA EXPRESSÃO DE MTOR EM TECIDOS DE FÊMEAS DA ESPÉCIE MESOCRICETUS AURATUS INFECTADOS COM O VÍRUS ZIKA." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6778.

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Introdução: Arbovírus são reconhecidos pela Organização Mundial de Saúde (OMS) como um grande problema de Saúde Pública devido à sua expansão territorial e necessidades de controle e prevenção, as quais são complexas. O vírus Zika (VZIK) está entre os arbovírus que apresentam maior circulação. Objetivo: Portanto, este estudo objetivou avaliar a expressão de mTOR em tecidos de fêmeas da espécie Mesocricetus auratus infectados com o vírus Zika. Metodologia: As amostras infectadas foram provenientes de um estudo prévio intitulado “infecção experimental do vírus Zika em Hamsters Dourados (Mesocric
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Yee, D., and N. J. Nassikas. "Tortured by mTOR Inhibitors? A Case of Pneumocystis Pneumonia Originally Diagnosed as mTOR Pneumonitis." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1413.

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Grabiner, Brian, Nikhil Wagle, Eliezer Van Allen, Levi Garraway, Jochen Lorch, and David Sabatini. "Abstract PR04: mTOR mutations in cancer." In Abstracts: AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; September 14-17, 2014; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-8514.pi3k14-pr04.

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O'Callaghan, M., M. Alquier, C. O'Brien, et al. "Mtor Signalling and More in Dipnech." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2244.

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Bezrukova, A. I., K. S. Basharova, I. V. Miliukhina, S. N. Pchelina, and T. S. Usenko. "EXPRESSION OF AUTOPHAGY-RELATED GENES IN GBA1 MUTATIONS CARRIERS WITH AND WITHOUT PARKINSON’S DISEASE." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-297.

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The molecular mechanisms of the neurodegenerative disease, Parkinson’s disease (PD), associated with mutations in the GBA1 gene (GBA-PD) are unknown. Recent data point to the role of autophagy, in particular of the PI3K/AKT/mTOR pathway, in PD pathogenesis. The study revealed pronounced alterations in the expression of autophagy-related genes are involved in the PI3K/AKT/mTOR pathway in GBA-PD. v
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Bezrukova, A. I., K. S. Basharova, M. M. Rudenok, et al. "MTOR-A POTENTIAL THERAPEUTIC TARGET FOR PARKINSON’S DISEASE WITH MUTATIONS IN THE GBA1 GENE." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-302.

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The molecular mechanisms of the neurodegenerative disorder Parkinson’s disease (PD) associated with mutations in the GBA1 gene which encodes the lysosomal enzyme glucocerebrosidase (GCase) gene, (GBA1-PD) are unknown. Transcriptome analysis of cellular and animal models with induced parkinsonism and GCase dysfunction, followed by subsequent validation, showed impairment of mTOR-dependent autophagy. The potential therapeutic significance of mTOR for the treatment of GBA1-PD was also assessed.
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Iskhakova, E. R., and I. I. Suvorova. "CANDIDATE REFERENCE GENE ANALYSIS FOR NORMALIZATION OF QRT-PCR DATA IN DORMANT CANCER CELLS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-239.

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Blockage of mTOR kinase leads to a decrease in tumor size and to the appearance of dormant cancer cells. Inhibition of mTOR is the basis for obtaining dormant cells in vitro. In this study, we demonstrated intracellular differences between normal and dormant cancer cells under the effect of AZD8055, and then evaluated 12 candidate genes to find the most relevant reference gene for normalization of quantitative PCR data.
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Cani, Alice, Carolina Simioni, Silvano Capitani, Alberto M. Martelli, and Luca M. Neri. "Abstract 3736: The mTOR inhibitor, RAD001, displays higher cytotoxicity in leukemias with hyperactivated PI3K/AKT/mTOR pathway." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3736.

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Reports on the topic "MTOR"

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Guan, Kun-Liang. Regulation of mTOR by Nutrients. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada569533.

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Guan, Kun-Liang. Regulation of mTOR by Nutrients. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada602038.

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ปาลกะ, ธนาภัทร. การพัฒนาระบบขนถ่ายดีเอ็นเอโดยใช้อนุภาคนาโนไคโทซานและการเหนี่ยวนำให้เกิดกระบวนการออโต้ฟาจีในเซลล์นำเสนอแอนติเจน : โครงการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2011. https://doi.org/10.58837/chula.res.2011.55.

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การทรานสเฟคชันโดยการนำพลาสมิดที่มีชิ้นยีนแทรกสอดเข้าสู่เซลล์เป็นขั้นตอนสำคัญในการประยุกต์ใช้งานด้านชีวเวชศาสตร์ เช่น การทำยีนบำบัด และวัคซีนชนิดดีเอ็นเอ เซลล์ส่วนใหญ่รับพลาสมิดเข้าสู่เซลล์ด้วยประสิทธิภาพที่ต่างกัน เซลล์นำเสนอแอนติเจน (Antigen Presenting Cell; APC) เช่น เซลล์เดนไดรติกและแมโครฟาจ เป็นหนึ่งในเซลล์ที่นำพลาสมิดเข้าสู่เซลล์ได้ยากที่สุด เซลล์เหล่านี้มีบทบาทสำคัญในการนำเสนอแอนติเจนต่อเฮลเปอร์ทีลิมโฟไซต์เพื่อชักนำให้มีการตอบสนองแบบ adaptive อย่างมีประสิทธิภาพ ในการที่จะกระตุ้นภูมิคุ้มกันได้อย่างมีประสิทธิภาพหลังจากการปลูกวัคซีนนั้น สามารถที่จะมุ่งเป้าแอนติเจนไปยังเซลล์นำเสนอแอนติเจน วั
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Ramesh, Vijaya, and Anat Stemmer-Rachamimov. Role of Merlin/NF2 in mTOR Signaling and Meningioma Growth. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada566365.

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Roberge, Michel. Study of mTOR Signaling Inhibitors as Potential Treatment for TSC. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada601809.

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Costa-Mattioli, Mauro. The Role of the New mTOR Complex, MTORC2, in Autism Spectrum Disorders. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613836.

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Barash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.

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Original objectives: The long-term goal of the research is to achieve higher protein content in the milk of ruminants by modulating the translational apparatus of the mammary gland genetically, nutritionally, or pharmacologically. The short-term objectives are to obtain a better understanding of 1) the role of amino acids (AA) as regulators of translation in bovine and mouse mammary epithelial cells and 2) the mechanism responsible for the synergistic enhancement of milk-protein mRNA polyadenylation by insulin and prolactin. Background of the topic: In many cell types and tissues, individual A
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Yu, Kyung, Latha Narayanan, John Schlager, Jeffery Gearhart, and Peter Robinson. Kinetic Behavior of Leucine and Other Amino Acids Modulating Cognitive Performance via mTOR Pathway. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada560396.

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Koks, Floor, Hymke van der Zee, Femke Reubens, and Jacco J. Briedé. The role of mTOR in Multiple Sclerosis pathophysiology: a protocol for a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2024. http://dx.doi.org/10.37766/inplasy2024.5.0101.

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Gan, Yena, Jinwei Huang, Duoduo Li, et al. PI3K/AKT/mTOR pathway and oral diseases: a bibliometric analysis from 2008 to 2025. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.6.0066.

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