Academic literature on the topic 'Myosin-based machine'

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Journal articles on the topic "Myosin-based machine"

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Bianco, Pasquale, Irene Pertici, Luca Melli, et al. "Force and Power of a Synthetic Myosin II-Based Machine." Biophysical Journal 112, no. 3 (2017): 116a—117a. http://dx.doi.org/10.1016/j.bpj.2016.11.656.

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Matsuura, H., M. Nakano, and T. Nemoto. "3L1015 Kinetic Thoery of Molecular Machine based on Thermal Noise : Actin-Myosin and Molecular Motor." Seibutsu Butsuri 42, supplement2 (2002): S185. http://dx.doi.org/10.2142/biophys.42.s185_4.

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Pertici, Irene, Lorenzo Bongini, Luca Melli, et al. "The Power of a Synthetic Machine Based on the Fast Myosin Isoform of Skeletal Muscle." Biophysical Journal 114, no. 3 (2018): 211a. http://dx.doi.org/10.1016/j.bpj.2017.11.1181.

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Horowitz, R. A., C. M. Powers, P. Valero, and R. Craig. "The Three Dimensional Organization of Smooth Muscle: Information from Serial Section Reconstructions." Microscopy and Microanalysis 4, S2 (1998): 438–39. http://dx.doi.org/10.1017/s1431927600022315.

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Smooth muscle is a machine consisting of working and supporting elements whose structure and 3D organization must be elucidated for the mechanics of shortening and tension generation to be understood. Based on longitudinal and serial transverse sections of rabbit portal vein it was suggested that the contractile elements of smooth muscle formed “mini-sarcomeres”, analogous to skeletal muscle, containing parallel arrays of 3-5 myosin filaments 1.6-2.2 um long. Observations at the light microscopic level were consistent with this idea. The past decade has seen little further investigation into t
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Willison, Keith Robert. "The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring." Biochemical Journal 475, no. 19 (2018): 3009–34. http://dx.doi.org/10.1042/bcj20170378.

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Actin is folded to its native state in eukaryotic cytosol by the sequential allosteric mechanism of the chaperonin-containing TCP-1 (CCT). The CCT machine is a double-ring ATPase built from eight related subunits, CCT1–CCT8. Non-native actin interacts with specific subunits and is annealed slowly through sequential binding and hydrolysis of ATP around and across the ring system. CCT releases a folded but soft ATP-G-actin monomer which is trapped 80 kJ/mol uphill on the folding energy surface by its ATP-Mg2+/Ca2+ clasp. The energy landscape can be re-explored in the actin filament, F-actin, bec
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Lansing Taylor, D. "Temporal and Spatial Dynamics of the Actin-Based Cytoskeleton." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 2 (1990): 546. http://dx.doi.org/10.1017/s0424820100136337.

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There has been a renaissance and revolution in the use of light microscopy in the biomedical sciences. The renaissance has been due to the importance of studying the temporal and spatial dynamics of ions, metabolites and macromolecules in living cells and tissues. The revolution has been due to the integration of developments in molecular biology, fluorescent probe chemistry, machine vision, and imaging technology. It is now possible to use the living cell as a microcuvette and to explore the chemical and molecular dynamics responsible for cellular functions.We have been investigating the form
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Ghulam, Ali, Rahu Sikander, Dhani Bux Talpur, et al. "IDENTIFYING MOLECULAR FUNCTIONS OF DYNEIN MOTOR PROTEINS USING EXTREME GRADIENT BOOSTING ALGORITHM WITH MACHINE LEARNING." Journal of Mountain Area Research 8 (November 29, 2022): 1. http://dx.doi.org/10.53874/jmar.v8i0.166.

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The majority of cytoplasmic proteins and vesicles move actively primarily to dynein motor proteins, which are the cause of muscle contraction. Moreover, identifying how dynein are used in cells will rely on structural knowledge. Cytoskeletal motor proteins have different molecular roles and structures, and they belong to three superfamilies of dynamin, actin and myosin. Loss of function of specific molecular motor proteins can be attributed to a number of human diseases, such as Charcot-Charcot-Dystrophy and kidney disease. It is crucial to create a precise model to identify dynein motor prote
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Eggers, Britta, Karin Schork, Michael Turewicz, et al. "Advanced Fiber Type-Specific Protein Profiles Derived from Adult Murine Skeletal Muscle." Proteomes 9, no. 2 (2021): 28. http://dx.doi.org/10.3390/proteomes9020028.

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Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and disease. Thus, examination of the skeletal muscles at the fiber type level is essential to detect potential alterations. Therefore, we established a protocol in which myosin heavy chain isoform immunolabeled muscle fibers were laser microdissected and separately investigated by mass spectrometry to develop advanced proteomic profiles of all murin
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Safari, Zohreh, Stephen C. Rogers, Mary E. Brummet, et al. "Oxygen Responsive Myosin Activation Governs Oscillatory Piezo1 Signaling in RBCs during Circulatory Transit." Blood 144, Supplement 1 (2024): 2453. https://doi.org/10.1182/blood-2024-207417.

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BACKGROUND: In mature red blood cells (RBCs), endothelial nitric oxide synthase (eNOS) migrates from cytosol to membrane in an O₂-dependent fashion (i.e., eNOS exhibits cyclic translocation/activation within RBCs during circulation). Upon RBC deoxygenation, RBC eNOS associates with the membrane and is activated, playing an important role in glycolytic metabolon disassembly and regulation of RBC energetics. We have previously demonstrated that eNOS translocation and activation is mechanistically linked to (1) deoxyHb docking on the Band 3 cytoplasmic domain (cdB3), followed by (2) Piezo1-based
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Chen, Zhongning, Tyler Fugere, and Yadav Pandey. "Expression profile of micro-RNA of lymphovascular invasive colon cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16109-e16109. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16109.

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e16109 Background: Lymphovascular invasion (LVI) is an independent predictor of disease progression in patients with colorectal cancer, and is often associated with high tumor grade and advanced tumor stage. In concordance, micro-RNA(miRNA), which are small non-coding RNA that regulate post-transcriptional gene expression, have also recently been shown to be promising biomarkers to predict disease prognosis. The purpose of this study is to investigate [1] potential mechanism of tumor invasion by identifying miRNA that are differentially expressed with respect to LVI status, and [2] create a mo
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Dissertations / Theses on the topic "Myosin-based machine"

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Pertici, Irene. "The power output of a myosin II-based nanomachine mimicking the striated muscle." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1041106.

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This thesis reports the realization and first application of a synthetic nanomachine, able to reproduce in vitro the performance emerging from the array arrangement of myosin II motors in the sarcomere of the striated muscle. The nanomachine consists of an ensemble of less than ten myosin dimers from fast skeletal muscle disposed on a functionalized support carried by a piezoelectric nanopositioner and brought to interact with an actin filament attached with the correct polarity via gelsolin to a bead (Bead Tailed Actin, BTA) trapped into the focus of a Dual Laser Optical Tweezers (DLOT). In s
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Conference papers on the topic "Myosin-based machine"

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Culver, Dean, Bryan Glaz, and Samuel Stanton. "A Dynamic Escape Problem of Molecular Motors." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-88612.

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Animal skeletal muscle exhibits very interesting behavior at near-stall forces (when the muscle is loaded so strongly that it can barely contract). Near this physical limit, the actinmyosin cross bridges do more work than their energy releasing molecules, Adenosine TriPhosphate (ATP) suggest they can. It has been shown that the advantageous utilization of thermal agitation is a likely source for this increased capacity. Here, we propose a spatially two-dimensional mechanical model to illustrate how thermal agitation can be harvested for useful mechanical work in molecular machinery without rat
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