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1

Freye, Enno. Opioid Agonists, Antagonists and Mixed Narcotic Analgesics. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71854-0.

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2

Faguet, Guy B. Pain control and drug policy: A time for change. Praeger, 2010.

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3

Faguet, Guy B. Pain control and drug policy: A time for change. Praeger, 2010.

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4

Faguet, Guy B. Pain control and drug policy: A time for change. Praeger, 2010.

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5

Jacob, Stanley W. MSM - the definitive guide: A comprehensive review of the science and therapeutics of methylsulfonylmethane. Freedom Press, 2003.

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6

1926-, Lawrence Ronald Melvin, and Zucker Martin, eds. The miracle of MSM: The natural solution for pain. Putnam, 1999.

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7

T, Parfitt Robert, ed. Opioid analgesics: Chemistry and receptors. Plenum Press, 1986.

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8

Canada. Health and Welfare Canada., ed. Prescribing information: Diamorphine hydrochloride b.p. (diacetylmorphine, heroin) : narcotic analgesic. Health and Welfare Canada, Health Protection Branch, 1985.

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9

Freye, Enno. Opioid agonists, antagonists and mixed narcotics analgesics: Theoretical background and considerations for practical use. Springer, 1987.

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10

1944-, Foley Kathleen M., and Inturrisi Charles E, eds. Opioid analgesics in the management of clinical pain. Raven Press, 1986.

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11

1949-, Gerber Wolf-Dieter, and Nappi G, eds. Update on non-narcotic analgesic research: Fiuggi, Italy, October 2nd-3rd, 1992. Birkhäuser Verlag, 1993.

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12

S, Rapaka Rao, Hawks Richard L, and National Institute on Drug Abuse., eds. Opioid peptides: Molecular pharmacology, biosynthesis, and analysis. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1986.

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13

S, Rapaka Rao, Barnett Gene, Hawks Richard L, and National Institute on Drug Abuse., eds. Opioid peptides: Medicinal chemistry. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1986.

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14

Henderson, Helen. The nurses' role in the management of post-operative pain, with specific reference to the knowledge and use of narcotic analgesia. The Author], 1990.

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15

Lyon, Joshua. Pill head: The secret life of a painkiller addict. Hyperion, 2009.

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16

Lyon, Joshua. Pill Head. Hyperion, 2009.

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17

Levinthal, Charles F. Messengers of paradise: Opiates and the brain : the struggle over pain, rage, uncertainty, and addiction. Anchor Press/Doubleday, 1988.

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18

Opioid Agonists, Antagonists and Mixed Narcotic Analgesics. Springer Verlag, 1987.

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19

Nurses' knowledge of pain assessment and narcotic analgesics. 1989.

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20

Parnham, M. J. Are the Medical Needs for the Treatment of Acute Pain Fulfilled?: Istanbul, Turkey, October 5th, 1996. Birkhauser, 1997.

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21

Parnham, Michael J., and International Symposium. Are the Medical Needs for the Treatment of Acute Pain Fulfilled: Istanbul, Turkey, October 5th, 1996. Birkhauser, 2000.

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22

(Editor), Giuseppe Nappi, and Wolf-Dieter Gerber (Editor), eds. Update on Non-Narcotic Analgesic Research: Fiuggi, Italy, October 2Nd-3Rd, 1992. Birkhauser, 1996.

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23

Opioid Agonists, Antagonists and Mixed Narcotic Analgesics: Theoretical Background and Considerations for Practical Use. Springer, 2012.

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24

Opioid Agonists, Antagonists and Mixed Narcotic Analgesics: Theoretical Background and Considerations for Practical Use. Springer, 1987.

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25

Parnham, Michael J. Non-Opioid Analgesics in the Treatment of Acute Pain: Johannesbergs Slott, Sweden, March 14th, 1996. Birkhauser, 1997.

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26

Non-Opioid Analgesics in the Treatment of Acute Pain: Johannesbergs Slott, Sweden, March 14 1996. Birkhauser Verlag, 2012.

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27

Non-opioid analgesics in the treatment of acute pain: Johannesbergs Slott, Sweden, March 14th, 1996. Birkhäuser Verlag, 1997.

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28

Wijdicks, Eelco F. M., and Sarah L. Clark. Pain Management. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190684747.003.0004.

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Adequate pain control has a high priority. In any acute neurologic pain syndrome it must be assumed that pain management is possible, effective, and simple; unfortunately, most patients in pain have been poorly managed. The pharmacopeia of pain management is growing and changing and several trends have been noted. Pain is underreported in the intensive care unit and should be treated when indicated. Acetaminophen is often the first agent used in pain management. Next are weak narcotic analgesics which could have less severe side effects than stronger opioid analgesics. This chapter discusses t
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29

Cascorbi, Ingolf. Polymorphic cytochrome P450 2D6 as the responsible enzyme of activation. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0079.

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The landmark paper discussed in this chapter is ‘Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)’, published by Dayer et al. in 1988. Codeine is an old but frequently prescribed drug used for the treatment of mild-to-moderate pain. However, its use is nowadays restricted after observations of partly fatal respiratory repression in children. Codeine itself exhibits no analgesic effect, but is partly activated by O-demethylation to morphine by cytochrome P450 2D6 (CYP2D6). T
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30

Horace Wells (1815-1848) et Villiam T.G. Morton (1819-1869): La rencontre improbable de deux précurseurs de l'anesthésie. L'Harmattan, 2013.

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31

Rai, Samarpit, Zachariah G. Goldsmith, Michael E. Lipkin, and Glenn M. Preminger. Ureteric stones. Edited by John Reynard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0026.

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Acute renal colic is a common presentation to the emergency department. It is estimated that about 12% of men and 5% of women will have at least one symptomatic stone by the age of 70. Renal colic has an annual incidence 16 cases per 10,000 per year, and a lifetime incidence of 2–5%. In the year 2000, there were over 600,000 emergency room visits for urolithiasis listed as the primary diagnosis in the United States alone. In this chapter, acute pharmacologic management of patients diagnosed with ureteral stones will be outlined. The pharmacology and clinical efficacy for narcotic and non-narco
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32

Hester, Joan. Opioids in palliative care. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0018.

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Before Twycross published the paper discussed in this chapter, the use of opioids in palliative care was more folkloric than evidence based, relying on the wisdom of the ages rather than being observation based: patients with advanced cancer received little or no narcotic (opioid) analgesics because of fears of addiction, of rapid escalation in dose, and of impairment of mental faculties. This paper, published in 1975, was instrumental in questioning some of the myths that had surrounded the dark art of opioid use, and expounding a rational and practical treatise for their use in palliative ca
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33

An, Howard. Cervical spine disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.003001.

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♦ Degenerative cervical spine disorders may manifest clinically with axial neck pain, radiculopathy, myelopathy, or a combination of these clinical symptoms♦ The findings on radiographs and MRI are pertinent if they correlate with the clinical symptoms♦ The initial treatment for patients with degenerative cervical spine disorders is conservative, including non-narcotic analgesics, anti-inflammatory medications, exercise program, physiotherapy, and occasional injections♦ Surgical indications include significant radicular pain despite conservative treatment, profound neurologic deficits, and pre
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34

Casy, A. F., and R. T. Parfitt. Opioid Analgesics: Chemistry and Receptors. Springer, 2013.

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35

Jacob, Stanley W., and Stanley W. Jacob MD. The Miracle of MSM:The Natural Solution for Pain. Berkley Trade, 1999.

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36

Dalal, Priti G., and Meghan Whitley. Pectus Excavatum. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0018.

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Pectus excavatum is a funnel-shaped congenital deformity of the chest. Although the deformity can appear minimal at birth, it may be progressive. There may be cardiac or pulmonary compromise in addition to subjective complaints of pain and shortness of breath. Management ranges from breathing exercises to surgical repair with mobilization of the sternum and ribs. This can be performed using an open or thoracoscopic technique. Complications of surgical repair include atelectasis and pneumothorax. Significant pain is associated with the surgical procedures and multimodal analgesic therapy, inclu
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37

World Health Organization (WHO). Persisting Pain in Children. World Health Organization, 2012.

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38

Freye, Enno. Opioide in der Medizin. 6th ed. Springer, 2004.

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39

Freye, Enno. Opioide in der Medizin. 7th ed. Springer, 2008.

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40

Yaksh, T. L., and H. Müller. Spinal Opiate Analgesia: Experimental and Clinical Studies. Springer London, Limited, 2012.

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41

Parker, Philip M. The 2007-2012 World Outlook for Opium and Opium-Derivative Narcotic Internal Analgesic and Antipyretic Pharmaceutical Preparations. ICON Group International, Inc., 2006.

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42

Parker, Philip M. The 2007-2012 Outlook for Opium and Opium-Derivative Narcotic Internal Analgesic and Antipyretic Pharmaceutical Preparations in Japan. ICON Group International, Inc., 2006.

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43

Parker, Philip M. The 2007-2012 Outlook for Opium and Opium-Derivative Narcotic Internal Analgesic and Antipyretic Pharmaceutical Preparations in India. ICON Group International, Inc., 2006.

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44

Stockman, Joel, and Lisa Lee. Peripheral Nerve Blockade in the Pediatric Patient. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0056.

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Peripheral nerve blockade among the pediatric and adult population has seen continuous growth over the past decade. Improvements in ultrasonography and proven safety with minimal complications further the utilization of upper and lower extremity blockade. Procedures can safely be completed under general anesthesia in the pediatric patient. Catheters can be left in place to prolong blockade, allowing the patient to decrease narcotic pain medication for longer time periods. Contraindications include patient refusal, coagulopathy, and local infection. Continuous peripheral nerve blocks deliver pr
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45

Parker, Philip M. The 2007-2012 Outlook for Opium and Opium-Derivative Narcotic Internal Analgesic and Antipyretic Pharmaceutical Preparations in Greater China. ICON Group International, Inc., 2006.

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46

Parker, Philip M. The 2007-2012 Outlook for Opium and Opium-Derivative Narcotic Internal Analgesic and Antipyretic Pharmaceutical Preparations in the United States. ICON Group International, Inc., 2006.

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47

Fever and antipyresis: The role of the nervous system. Cambridge University Press, 1995.

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48

Stein, Christoph. Opioids in Pain Control: Basic and Clinical Aspects. Cambridge University Press, 2010.

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49

Stein, Christoph. Opioids in Pain Control: Basic and Clinical Aspects. Cambridge University Press, 2011.

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50

Dubose, Arielle C., and SreyRam Kuy. A Comparison of Laparoscopically Assisted and Open Colectomy for Colon Cancer. Edited by SreyRam Kuy and Miguel A. Burch. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199384075.003.0010.

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The landmark COST trial compared outcomes between minimally invasive surgery and open surgical resection for patients with colon cancer. The study found that patients with operable right, left, or sigmoid colon cancer, either laparoscopic-assisted or open colectomy may be offered without compromising the risk of tumor recurrence or mortality. Patients who underwent colectomy via a laparoscopic-assisted approach, compared to open, had a shorter length of hospital stay and required parenteral narcotics and oral analgesics for less time, while having equal rates of intraoperative and postoperativ
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