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Dissertations / Theses on the topic 'Natural Drug Development'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Jurkiewicz, Crystal A. "Analysis of soy natural products and esterase enzymes for drug development." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1307463707.

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2

Dinarvand, Mojdeh. "Discovery and development of novel antibacterials from natural products." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18569.

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with a variety of moderate to severe infections. The multi-drug resistant nature of this pathogen makes treatment difficult. The main aim of this study was to screen a library of marine samples for novel compounds with antibacterial activity. A high-throughput assay was developed to identify active extracts, followed by determination of minimum inhibitory concentrations (MICs) for hits. The toxicity of marine samples was measured against different cells lines. Crude extracts were purified using column chrom

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3

Hatherley, Rowan. "Structural bioinformatics studies and tool development related to drug discovery." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1020021.

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This thesis is divided into two distinct sections which can be combined under the broad umbrella of structural bioinformatics studies related to drug discovery. The first section involves the establishment of an online South African natural products database. Natural products (NPs) are chemical entities synthesised in nature and are unrivalled in their structural complexity, chemical diversity, and biological specificity, which has long made them crucial to the drug discovery process. South Africa is rich in both plant and marine biodiversity and a great deal of research has gone into isolatin

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4

Johnston, Heather Jennifer. "Development of novel analogues of the anti-proliferative marine natural product bisebromoamide : synthesis and structure activity relationship studies." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17617.

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The linear peptide bisebromoamide was isolated by the Suenaga group in 2009 from the marine cyanobacterium Lyngbya sp. It exhibits antiproliferative activity at nanomolar levels against a wide range of cell lines. Current SAR data indicates that there is some flexibility in the structure with respect to stereochemistry, but the range of modifications that have been biologically tested is limited, as reviewed in Chapter 1. Bisebromoamide contains a number of non-commercial amino acids and an oxopropyl pyrrolidine moiety which had not been found in a natural product previously. Several new synth

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5

Cockroft, Nicholas T. "Applications of Cheminformatics for the Analysis of Proteolysis Targeting Chimeras and the Development of Natural Product Computational Target Fishing Models." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156596730476322.

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6

Oliva, Francisco. "The Anti-cancer Properties of Podophyllotoxin Analogues." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1579197212456721.

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7

Menzies, Stefanie Kate. "Investigating the trypanocidal activity of simplified natural product-like analogs and the characterization of a novel trypanosomatid-specific secondary alternative oxidase." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12041.

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This thesis aimed to identify the trypanocidal mode of action of non-natural chamuvarinin analogs, and to assess the previously uncharacterized secondary alternative oxidase (AOX2) as a possible drug target of the trypanosomatids. The drugs used to treat infections with Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are highly toxic and are increasingly becoming less effective as the parasites develop resistance, therefore new drugs against the diseases are desperately needed. Non-natural analogs of chamuvarinin were tested for trypanocidal activity to determine the structure activi

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8

Gabriele, E. "SYNTHESIS OF NEW SULFURATED DERIVATIVES OF NATURAL AND SYNTHETIC SYSTEMS AS MULTITARGET ANTICANCER AGENTS AND DEVELOPMENT OF NEW DRUG DISCOVERY METHODOLOGIES." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/473431.

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This PhD thesis is divided in two parts. The former, entitled "Design and synthesis of new derivatives of natural and synthetic systems endowed with anticancer activity, through a multitarget mechanism", has been carried out at the Universitá degli Studi di Milano under the supervision of Professor Anna Sparatore. This project treats the synthesis of new sulfurated compounds with the aim of obtaining anticancer agents acting through a multitarget mechanism. On one hand, we explored the potentialities of new sulfurated chemical scaffolds, such as dithiolethiones, methanethiosulfonates and allyl

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9

Lock, de Ugaz Olga. "Bioassay methods in natural product research and drug development. Lars Bohlin and Jan G. Bruhn Ed. Kluwer Academic Publishers, The Netherlands, 1999,201 p." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100706.

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10

Martínez, Pérez Carlos. "Evaluation of the antitumour activity of novel flavonoids on pre-clinical models of breast and ovarian cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25410.

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New drugs are needed for better cancer management. Clinical trials are currently underway to assess the use of flavonoids (natural polyphenols) as anticancer agents. Among them, myricetin has been shown to induce cell cycle arrest and apoptosis in pre-clinical cancer models. We hypothesised that myricetin-derived novel flavonoids designed to enhance this natural potential and improve on the drug-likeness limitations of myricetin might have increased potential for their application in the management of breast and ovarian cancer. The effect of a library of novel flavonoids was screened on 3 pane

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11

Abdelhamid, Dalia. "Natural Products as Lead Compounds for Drug Development. Part I: Synthesis and Biological Activity of a Structurally Diverse Library of Curcumin Analogues. Part II: Synthesis of Novel Sterol Natural Products and Related Analogues as Antileishmanial Ag." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299685922.

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12

Manwill, Preston Kim. "Discovery and Development of Natural Products from Plant and Microbial Sources: Drimane Sesquiterpenes and Abyssomicins as Mosquito Control and Antimicrobial Agents." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1591285556969447.

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13

Ntie-Kang, Fidele [Verfasser], Wolfgang [Gutachter] Sippl, Gerhard [Gutachter] Wolber, and Frank M. [Gutachter] Boeckler. "Drug discovery from African medicinal plants : natural product database development, lead discovery and toxicity assessment ; kumulative Habilitationsschrift / Fidele Ntie-Kang ; Gutachter: Wolfgang Sippl, Gerhard Wolber, Frank M. Boeckler." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2021. http://d-nb.info/1229436553/34.

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14

Gil, Escolano Alejandro. "Studies toward the synthesis of marine natural products Phormidolides B-D." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/544128.

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Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact with their biological target and the special and unique conditions present in seas, lakes, oceans and rivers allow the biosynthesis of highly potent compunds. Nowadays, the processes to discover a new drug from MNPs are bio-assay guided, giving more importance to the biological results rather than to the molecular structure. After a molecular entity has shown to be biologicall

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15

Huntsman, Andrew C. "Development of Phyllanthusmin Derivatives as Anticancer Agents: Pharmacological Optimization and Mechanistic Insight." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156338449662965.

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16

Wright, Colin W. "Recent developments in research on terrestrial plants used for the treatment of malaria." Royal Society of Chemistry, 2010. http://hdl.handle.net/10454/4541.

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no<br>New antimalarial drugs are urgently needed to combat emerging multidrug resistant strains of malaria parasites. This Highlight focuses on plant-derived natural products that are of interest as potential leads towards new antimalarial drugs including synthetic analogues of natural compounds, with the exception of artemisinin derivatives, which are not included due to limited space. Since effective antimalarial treatment is often unavailable or unaffordable to many of those who need it, there is increasing interest in the development of locally produced herbal medicines; recent progre

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17

Garad, D. N. "Development of nitrogen directed C-H activation protocols for the synthesis of natural products, drugs and new scaffolds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4544.

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The thesis is mainly based on the development and application of nitrogen directed C‒H activation methodologies in the synthesis of natural products, new scaffolds, and drugs. We have successfully developed Pd‒catalyzed “olefin amidation/C‒H activation” protocol for the synthesis of (±)-8- oxocanadine and (±)-8-oxostylopine protoberberine alkaloids and formal synthesis of the drug tetrahydropalmatine. Quinazolinone directed C(sp2)‒arylation and C(sp3)‒acetoxylation protocols have also been developed for the synthesis of new quinazolinones using Pd-catalysis. Novel Ru‒catalyzed regioselec

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18

Swan, Leesa Michelle. "The Development of New DNA Alkylating Antitumour Agents Modeled on the Natural Product CC-1065." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/367931.

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Preliminary studies have revealed that the 4-hydroxyphenethyl halides possess the minimal structural requirements needed to mimic the DNA alkylation profile characteristic to seco-CPI subunits. Subsequent assessment of the 4-aminophenethyl halides showed that these adducts exhibit approximately four times the in vitro cytotoxicity demonstrated by their phenolic counterparts. The incorporation of these simpler compounds into more complex molecules containing non-covalent binding subunits was expected to increase both cytotoxicity and sequence selectivity. Biological assessment of the synthesize

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19

Ghadzi, Siti Maisharah Sheikh. "Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317040.

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Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM. The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. The appropriate

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20

Bou, Petit Elisabeth. "Sensitizing triple negative breast cancer to approved therapies: Design, synthesis and biological activity of MNK inhibitors." Doctoral thesis, Universitat Ramon Llull, 2019. http://hdl.handle.net/10803/667814.

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La desregulació de la síntesi de proteïnes és comuna en càncer. Un factor clau en el control de la traducció de proteïnes és el factor d'inici de la traducció 4E (eIF4E) que es troba regulat per les cinases MNK1/2 (MAP kinase interacting kinases 1 i 2) mitjançant fosforilació. En els últims anys, l’eIF4E s'ha descrit com un factor de pronòstic independent associat amb la progressió maligna i el desenvolupament de resistència. A més, l’eIF4E es troba sobreexpressat en càncer d'ovari, mama, pulmó, bufeta i pròstata. La fosforilació de l'eIF4E és necessària per a la transformació tumoral però és

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21

Freitas, Beatriz Resende. "Avaliação da atividade antimicrobiana de extratos de folhas de Lippia salviaefolia Cham. visando sua aplicação como conservante em preparações cosméticas." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-23122016-094320/.

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O potencial farmacológico de espécies do gênero Lippia no tratamento de infecções é conhecido popularmente, assim foi considerado o estudo da atividade da Lippia salviaefolia nativa do cerrado brasileiro. O objetivo do trabalho foi avaliar a atividade antimicrobiana de extratos de Lippia salviaefolia Cham. e sua citotoxicidade, visando aplicação como conservante natural em formulações cosméticas. O ensaio antimicrobiano foi realizado através do método de difusão em placa e determinação do CMI por de microdiluição em microplacas, utilizando os microrganismos: P. aeruginosa ATCC 9027, S. aureus

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22

Gilabert, Porres Joan. "Development and customization of new 3D generation tracheal prosthesis with different biological activities regarding to their functional side." Doctoral thesis, Universitat Ramon Llull, 2017. http://hdl.handle.net/10803/402441.

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Els stents són tubs expansibles fets de diferents materials que s'utilitzen per obrir conductes que han estat obstruïts. Específicament, en el camp dels stents traqueals, existeix una necessitat de millora per evitar els problemes post-implantació, tals com la colonització bacteriana, la formació de teixit de granulació, la migració del dispositiu i el dolor agut. La colonització bacteriana per microorganismes potencialment patògens (PPM, sigles en anglès) redueix la qualitat de vida dels pacients, indueix infecció o fins i tot sèpsia, i pot conduir a la mort del pacient si no es prenen les me

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23

Dias, Joana Nunes Ribeiro. "Clinical and immunological characterization of naturally occurring canine lymphoma : development and application of engineered recombinant antibodies for diagnosis and treatment." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/17735.

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Tese de Doutoramento em Ciências Veterinárias. Especialidade de Sanidade Animal<br>Non-Hodgkin lymphoma (NHL) is one of the most common causes of cancer-related death worldwide. Although the outcome of NHL patients has improved with current therapies, the rate of mortality is still high. A plethora of new drugs is entering clinical development for NHL treatment; however, the approval of new treatments remains low due in part to the paucity of clinically relevant models for validation. Canine lymphoma (cNHL) shares remarkable similarities with its human counterpart, making the dog an excellent

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24

Weber, Lisa [Verfasser], Karsten [Akademischer Betreuer] Feige, Jessika [Akademischer Betreuer] Cavalleri, Manfred [Akademischer Betreuer] Kietzmann, and Wolfgang [Gutachter] Bäumer. "In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark / Lisa Annabel Weber ; Gutachter: Wolfgang Bäumer ; Karsten Feige, Jessika-M.V. Cavalleri, Manfred Kietzmann." Göttingen : Cuvillier Verlag, 2021. http://d-nb.info/123539915X/34.

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25

Ferreira, Abigail Filipe. "Development of New Peptide-Drug Conjugates for Cancer Therapy." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/90028.

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Ferreira, Abigail Filipe. "Development of New Peptide-Drug Conjugates for Cancer Therapy." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/90028.

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27

Lin, Chun-kuang, and 林俊光. "Development of antiviral drugs from marine natural products and investigation of drug target against virus." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9s549w.

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博士<br>國立中山大學<br>海洋生物科技博士學位學程<br>106<br>Hepatitis C virus (HCV) infection causes chronic inflammation of liver, leading to the development of cirrhosis and hepatocellular carcinoma (HCC). Infection of dengue virus (DENV) caused diseases ranging from acute self-limiting febrile illness to life-threatening dengue hemorrhagic fever and dengue shock syndrome. The purposes of present dissertation are to discover the anti-viral agents from marine natural products and to investigate the impact of cellular factors on DENV replication. For finding the potential antivirals, we found that betulinic acid (

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28

Poka, Madan Sai. "Investigation of natural polymer systems to control Nicotinic acid relase." 2011. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000544.

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M. Tech. Pharmaceutical Sciences.<br>Aims to design, evaluate and optimize an extended release matrix tablet of Nicotinic acid using natural polymers to match the in-vitro dissolution profile of Niaspan.

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29

Vasconcelos, Teófilo Cardoso de. "Development of a resveratrol drug delivery system presenting enhanced bioavailability." Doctoral thesis, 2021. https://hdl.handle.net/10216/135858.

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Vasconcelos, Teófilo Cardoso de. "Development of a resveratrol drug delivery system presenting enhanced bioavailability." Tese, 2021. https://hdl.handle.net/10216/135858.

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31

Tekle-Smith, Makeda Aislinn. "Synthetic Innovations Towards the Total Synthesis of Natural Product Derivatives for Drug Development." Thesis, 2019. https://doi.org/10.7916/d8-ypj5-jh11.

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In order to provide scalable, efficient and selective routes towards pharmaceutically relevant compounds, we have focused on improving the economical viability and practicality of strained-silane Lewis acid activation. Towards these goals, the Leighton group has developed a new mode of anion catalysis to activate silane Lewis acids. Weakly coordinating anions have been used to access hyper-coordinate silicon species with unprecedented levels of reactivity, which have facilitated previously unattainable complex fragment couplings. A highly enantioselective and efficient method for anion catalyz

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32

Campos, Daniela Priscila Rodrigues Lopes de. "Improvement of the current therapy against Helicobacter pylori: biophysical studies of drug-membrane interactions and development of a drug delivery system." Doctoral thesis, 2018. https://hdl.handle.net/10216/113604.

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33

Campos, Daniela Priscila Rodrigues Lopes de. "Improvement of the current therapy against Helicobacter pylori: biophysical studies of drug-membrane interactions and development of a drug delivery system." Tese, 2018. https://hdl.handle.net/10216/113604.

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34

Pinto, Ana Rita Oliveira Macedo. "Staphylococcus aureus implant-associated biofilms: development of a novel nanoparticle-based drug delivery system." Doctoral thesis, 2022. https://hdl.handle.net/10216/139924.

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35

Wright, Colin W. "Searching for new treatments of malaria." 2015. http://hdl.handle.net/10454/7418.

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no<br>The aim of this chapter is to illustrate some current developments in natural product-derived antimalarial drugs. Traditional medicines have provided two of our most important antimalarial drugs (quinine and artemisinin) and have the potential to provide many novel antimalarial lead compounds of which several examples will be discussed. In addition, well- known natural antimalarials such as artemisinin continue to be an important focus of research and there is also increasing interest in investigating natural product sources that have not been traditionally used as antimalarials such a

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Ferreira, Abigail Filipe. "Development of a new pharmacokinetic model using in silico studies, drug delivery systems and analytical methods." Doctoral thesis, 2021. https://hdl.handle.net/10216/138184.

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37

Alsherbiny, Muhammad A. "Adventures in natural products drug discovery : metabolomic, proteomic, synergy and deep learning studies." Thesis, 2021. http://hdl.handle.net/1959.7/uws:67234.

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In the present project, integrated untargeted metabolomic profiling and antiproliferative assays were implemented for smart identification of the antiproliferative metabolites of Australian propolis against MCF7 breast cancer cells. The synergistic chemotherapeutic combinations of the Australian propolis or cannabinoids such as cannabidiol were investigated and validated against different synergy quantitation models and designs. Moreover, label-free quantification proteomics studies were employed to elucidate the potential mechanism of action and biological targets of the mono treatment or the

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38

Twining, Robert Chiampi. "The development of a novel rodent model of drug induced devaluation of natural rewards and its relevance to features of drug addiction." 2007. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2249/index.html.

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Karnik, Shreyas. "Mining Biomedical Literature to Extract Pharmacokinetic Drug-Drug Interactions." Thesis, 2014. http://hdl.handle.net/1805/3912.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Polypharmacy is a general clinical practice, there is a high chance that multiple administered drugs will interfere with each other, such phenomenon is called drug-drug interaction (DDI). DDI occurs when drugs administered change each other's pharmacokinetic (PK) or pharmacodynamic (PD) response. DDIs in many ways affect the overall effectiveness of the drug or at some times pose a risk of serious side effects to the patients thus, it becomes very challenging to for the successful drug development and clinical patient care. Biomedica

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RIGHESCHI, CHIARA. "Development and optimization of nanocarriers for delivery of natural and semi-synthetic compounds in cancer therapy." Doctoral thesis, 2013. http://hdl.handle.net/2158/804100.

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The aim of the work has been the development and characterization of three different nanocarriers: solid lipid nanoparticles, polymeric nanocapsules and liposomes for the delivery of natural and semi-synthetic anticancer compounds.

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Thornburg, Christopher C. "Investigation of unique marine environments for microbial natural products." Thesis, 2013. http://hdl.handle.net/1957/37941.

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Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments, a high rediscovery rate has resulted in the investigation of unique, relatively unexplored ecosystems harboring phylogenetically diverse communities of marine organisms. The focus of this research was to establish a

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Martins, Fábio António Gouveia Ferreira. "Identification of New Drugs Against Biofilm Formation and Development." Dissertação, 2020. https://hdl.handle.net/10216/132102.

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Magalhães, Rita Prata Barbedo. "Identification of New Drugs Against Biofilm Formation and Development." Dissertação, 2019. https://hdl.handle.net/10216/124218.

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Magalhães, Rita Prata Barbedo. "Identification of New Drugs Against Biofilm Formation and Development." Master's thesis, 2019. https://hdl.handle.net/10216/124218.

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Martins, Fábio António Gouveia Ferreira. "Identification of New Drugs Against Biofilm Formation and Development." Master's thesis, 2020. https://hdl.handle.net/10216/132102.

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Chakraborti, Sohini. "Protein-small molecule interactions: Structural insights and applications in computational drug discovery." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5520.

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Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the disease conditions. The majority of the drugs currently available in the market are small organic molecules due to their pharmacological and commercial advantages. These small molecule drugs interact with the protein targets through specific sites on the surface of the protein structure (binding sites). Thus, the structural data of protein-small molecule complexes forms a cru

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Chen, Chien An, and 陳建安. "Development of novel effects of natural anticancer drugs." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/nghq26.

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博士<br>長庚大學<br>臨床醫學研究所中醫組<br>105<br>Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. Daphnoretin, an active constituent of Wikstroemiaindica C.A. Meys, has also been shown possessing anti-cancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. We examined the effect of daphnoretin on differentiation and maturation of human myeloid dendritic cells (DCs), too. The results showed moscatilin suppres

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Lucani, Bianca Celidet Pérez de. "Malaria chemotherapy and prevention: towards the development of dual action drugs and the understanding of vaccine-induced antibody responses against P. falciparum." Tese, 2013. https://repositorio-aberto.up.pt/handle/10216/70284.

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Lucani, Bianca Celidet Pérez de. "Malaria chemotherapy and prevention: towards the development of dual action drugs and the understanding of vaccine-induced antibody responses against P. falciparum." Doctoral thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/70284.

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Oliveira, Ana Catarina Gomes. "Benzoic acid as a valid scaffold for the development of dual-target directed drugs for Alzheimer's disease." Doctoral thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/108839.

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