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Journal articles on the topic 'Natural Drug Development'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lee, Gihyun. "Drug Development Using Natural Toxins." Toxins 13, no. 6 (2021): 414. http://dx.doi.org/10.3390/toxins13060414.

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2

Phillipson, J. D. "Natural Products and Drug Development." Trends in Pharmacological Sciences 6 (January 1985): 182–83. http://dx.doi.org/10.1016/0165-6147(85)90081-1.

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3

Brady, Lynn R. "Natural Products and Drug Development." Journal of Pharmaceutical Sciences 74, no. 8 (1985): 904–5. http://dx.doi.org/10.1002/jps.2600740829.

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4

Sardana, Satish. "Herbal drug development from natural sources." Journal of Advanced Pharmaceutical Technology & Research 3, no. 2 (2012): 82. http://dx.doi.org/10.4103/2231-4040.97274.

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5

Molinski, Tadeusz F., Doralyn S. Dalisay, Sarah L. Lievens, and Jonel P. Saludes. "Drug development from marine natural products." Nature Reviews Drug Discovery 8, no. 1 (2008): 69–85. http://dx.doi.org/10.1038/nrd2487.

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6

HC, Upadhyay. "Nature Inspired Discovery and Development of Antibacterials: An Update." Medicinal & Analytical Chemistry International Journal 8, no. 1 (2024): 1–5. http://dx.doi.org/10.23880/macij-16000193.

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The growing prevalence of pathogens resistant to several drugs poses an urgent health concern, which can only be addressed by increasing support for the research and development of newer antibiotics. Drug discovery through the exploration of nature's treasures is a successful and ongoing endeavor. However, the conventional method of discovering new drugs from natural sources has become an adjunct choice of the pharmaceutical corporations since it is time-consuming, complicated, expensive, and fraught with uncertainty. The application of several computational techniques, including combinatorial

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7

Alam, Fahmida, Md Asiful Islam, Mohammad Amjad Kamal, and Siew Hua Gan. "Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development." Current Medicinal Chemistry 25, no. 39 (2019): 5395–431. http://dx.doi.org/10.2174/0929867323666160813222436.

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Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are current

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8

Ali, Parniya Akbar, Farah Hanif, Hosna Nettour, and Mubashar Rehman. "Strategies and Techniques of Drug Discovery from Natural Products." Global Drug Design & Development Review II, no. I (2017): 34–43. http://dx.doi.org/10.31703/gdddr.2017(ii-i).04.

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New drugs are mostly obtained from Natural sources. The traditional and ethic medicines have provided evidence on the therapeutic properties and resulted in some distinguished drug discovery of natural products. The microorganisms and the endogenous active materials from human or animal have also become a significant approach to the discovery of a drug. Bioinformatics and artificial intelligence have facilitated the study and development of products. For discovery of natural products different software have been used. Different computational software needed in the future for the predicting fea

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Dr. Amit Ghosh. "Coconut: Natural Source of Potential Anti Cancer Agent." CORD 32, no. 1 (2016): 9. http://dx.doi.org/10.37833/cord.v32i1.45.

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The current strategy of drug development is time consuming and expensive. This contrasts sharply with the vision of affordable drug development. The costly and the lengthy paradigm of drug discoveries are major obstacles for combating with rapidly emerging and sporadic diseases. The dichotomy between the urgent requirement of affordable treatment development and the hindrance it faces is apparent in several recent literatures which reflects the importance of drug repurposing and development of botanical drugs. Consistent with this idea, past few decades of studies on Cocos nucifera has yielded

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TSUKAMOTO, Sachiko. "Study on Natural Products for Drug Development." YAKUGAKU ZASSHI 130, no. 10 (2010): 1273–81. http://dx.doi.org/10.1248/yakushi.130.1273.

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11

Cragg, Gordon M., David J. Newman, and Kenneth M. Snader. "Natural Products in Drug Discovery and Development." Journal of Natural Products 60, no. 1 (1997): 52–60. http://dx.doi.org/10.1021/np9604893.

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12

Rijo, Patricia. "Drug Development Inspired by Natural Products II." Molecules 28, no. 21 (2023): 7243. http://dx.doi.org/10.3390/molecules28217243.

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13

Tang, Siu Wa, and Wayne H. Tang. "Opportunities in Novel Psychotropic Drug Design from Natural Compounds." International Journal of Neuropsychopharmacology 22, no. 9 (2019): 601–7. http://dx.doi.org/10.1093/ijnp/pyz042.

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Abstract Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug developments were largely based on extension and modification of earlier molecular scaffolds. This limits their mechanisms of action to similar neuropathways. Natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may

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14

Anand, Kumar, Sayak Khawas, Apurva Singh, Puja kumari, Neha Nupur, and Neelima Sharma. "Harnessing the Power of Natural Products in Drug Discovery." Journal of Pharmaceutical Technology, Research and Management 11, no. 1 (2023): 1–18. http://dx.doi.org/10.15415/jptrm.2023.111001.

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Background: Natural products and their structural analogues have historically played a crucial role in pharmacotherapy, especially in the treatment of cancer and infectious diseases. However, various challenges including screening, isolation, characterization and effectiveness contributed to a decline in natural product research within the pharmaceutical industry. Purpose: This review explores the enduring use of natural compounds in folk medicine with special focus on drug discovery inspired by multifaceted molecular roles of small molecules from natural sources. The article also aims to eluc

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Najmi, Asim, Sadique A. Javed, Mohammed Al Bratty, and Hassan A. Alhazmi. "Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents." Molecules 27, no. 2 (2022): 349. http://dx.doi.org/10.3390/molecules27020349.

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Natural products represents an important source of new lead compounds in drug discovery research. Several drugs currently used as therapeutic agents have been developed from natural sources; plant sources are specifically important. In the past few decades, pharmaceutical companies demonstrated insignificant attention towards natural product drug discovery, mainly due to its intrinsic complexity. Recently, technological advancements greatly helped to address the challenges and resulted in the revived scientific interest in drug discovery from natural sources. This review provides a comprehensi

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Feng, Xiaoyi, Yuning Luo, Fangjie Li, Xueting Jian, and Yang Liu. "Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels." Gels 7, no. 3 (2021): 105. http://dx.doi.org/10.3390/gels7030105.

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Natural small molecular drugs with excellent biocompatibility, diverse pharmacological activities, and wide sources play an increasingly important role in the development of new drug and disease treatment. In recent years, the utilization of paclitaxel, camptothecin, rhein, curcumin, and other natural small molecular drugs with unique rigid backbone structures and modifiable multiple sites as building blocks to form gels by self-assembly has attracted widespread attention. The obtained low-molecular-weight supramolecular gel not only retains the general characteristics of the gel but also over

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Treml, Jakub, Markéta Gazdová, Karel Šmejkal, Miroslava Šudomová, Peter Kubatka, and Sherif T. S. Hassan. "Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development." Viruses 12, no. 2 (2020): 154. http://dx.doi.org/10.3390/v12020154.

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Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forwa

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Flaherty, Keith T., Dung T. Le, and Steven Lemery. "Tissue-Agnostic Drug Development." American Society of Clinical Oncology Educational Book, no. 37 (May 2017): 222–30. http://dx.doi.org/10.1200/edbk_173855.

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The U.S. Food and Drug Administration (FDA) has approved drugs to treat patients with tumor types based on a single anatomic site, such as renal cell carcinoma or melanoma, rather than on a biomarker alone. This standard approach is based on a number of factors, including heterogeneity of drug effects in different biomarker-positive tumor types. Additionally, drug development for some drugs was primarily directed toward a specific genomic abnormality in a specific tumor type (e.g., drugs for anaplastic lymphoma kinase [ALK] fusion-positive non–small cell lung cancer). In such cases, difference

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19

Kam, Antony, Shining Loo, and Simon Ming-Yuen Lee. "Editorial on Special Issue “Natural Products for Drug Discovery and Development”." Processes 11, no. 6 (2023): 1784. http://dx.doi.org/10.3390/pr11061784.

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E. Salomon, Christine, and Lori E. Schmidt. "Natural Products as Leads for Tuberculosis Drug Development." Current Topics in Medicinal Chemistry 12, no. 7 (2012): 735–65. http://dx.doi.org/10.2174/156802612799984526.

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21

Sharma, S. B., and Richa Gupta. "Drug Development from Natural Resource: A Systematic Approach." Mini-Reviews in Medicinal Chemistry 15, no. 1 (2015): 52–57. http://dx.doi.org/10.2174/138955751501150224160518.

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22

Curtis, Michael J. "New drug discovery and development from natural products." Pharmacology & Therapeutics 263 (November 2024): 108733. http://dx.doi.org/10.1016/j.pharmthera.2024.108733.

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23

Sukmarini, L. "Drug Development from Peptide-derived Marine Natural Products." IOP Conference Series: Materials Science and Engineering 1011 (January 6, 2021): 012063. http://dx.doi.org/10.1088/1757-899x/1011/1/012063.

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24

Oldham, Harriet. "O23 Drug development with natural products – A journey." Biochemical Pharmacology 139 (September 2017): 116–17. http://dx.doi.org/10.1016/j.bcp.2017.06.088.

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25

Nwosu, Samuel Nzube, Oluwabunmi Victoria Obagbemisoye, Christian Otitodilichukwu Onuba, and Suliat Eniola Balogun. "Advances in Anticancer Drug Discovery: Exploring the Untapped Potential of Natural Products for Targeted Therapies." Journal of Advances in Medical and Pharmaceutical Sciences 26, no. 11 (2024): 1–22. http://dx.doi.org/10.9734/jamps/2024/v26i11721.

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Natural products have long been a significant source of structurally diverse and biologically active compounds, making them important for anticancer drug development. Taxol, a natural product isolated from the bark of the Pacific yew tree, is used to treat some cancers; Vincristine, a related compound that was eked out of the Madagascar periwinkle plant, treats leukemia and lymphoma. This review provides recent advances and future perspectives on developing natural-product-derived anticancer agents. We introduce celebrated examples of successfully developed natural-product-derived anticancer d

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26

Chaachouay, Noureddine, and Lahcen Zidane. "Plant-Derived Natural Products: A Source for Drug Discovery and Development." Drugs and Drug Candidates 3, no. 1 (2024): 184–207. http://dx.doi.org/10.3390/ddc3010011.

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For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the design, discovery, and development of new drugs. With the invention of recent molecular targets based on proteins, there is a growing need for fresh chemical diversification in screening. Natural products will play a vital part in supplying this need via the continuous exploration of global biodive

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Ram, Rajesh, Laxmi Yadav, Amrit Gond, and Mamta Verma. "Nano Natural Products: A Potential Source for Safer Drug Development." Anusandhaan - Vigyaan Shodh Patrika 12, no. 01 (2024): 108–21. https://doi.org/10.22445/avsp.v12i1.18.

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nano scale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine or immunotherapeutic agents in the treatment of various diseases. The current investigation, presents an updated s

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Gehrig, Stefanie, and Thomas Efferth. "Development of Drug Resistance in Trichomonas vaginalis and its Overcoming with Natural Products." Open Bioactive Compounds Journal 2, no. 1 (2009): 21–28. http://dx.doi.org/10.2174/1874847300902010021.

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Trichomoniasis is an infectious disease afflicting women worldwide. The protozoan parasite Trichomonas vaginalis is the causative agent of this sexually-transmitted disease, including also men in its infection cycle. The disease is usually not life-threatening, but has been associated with the development of cervical cancer and increased susceptibility to HIV. Approved drugs are 5-nitroimidazoles, with metronidazole being the drug of first choice. These drugs act via induction of oxidative stress and DNA-damage, leading to cell death in the parasite. Nevertheless, with the development of resis

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29

Singh, Priyanka, and Shailendra K. Lariya. "FORMULATION DEVELOPMENT OF ACYCLOVIR MICROSPHERE USING NOVEL NATURAL POLYMER." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 271–76. http://dx.doi.org/10.22270/jddt.v8i5-s.1971.

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Acyclovir [9-(2-hydroxyethoxymethyl) guanine] is an acyclic nucleoside analogue of guanosine that is a potent and selective antiviral agent. It has a relatively short plasma half-life (3 hr). When orally administered, it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Acyclovir and produced sustained drug delivery. In these 14 batches of acyclovir microspheres was prepared with using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were

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30

Yuliandra, Yori, and Nova Syafni. "Integrating Computational Methods into Antibacterial Drug Discovery and Development from Natural Products." Jurnal Sains Farmasi & Klinis 11, no. 1 (2024): 80–85. http://dx.doi.org/10.25077/jsfk.11.1.80-85.2024.

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Natural products have long been pivotal in sustaining civilizations due to their medicinal properties and have served as a rich source of bioactive compounds for drug discovery. With the rise of antibiotic-resistant bacteria, there is an urgent need for new antibacterial agents. Natural products, with their diverse chemical structures, provide a promising reservoir for identifying new lead compounds. Historically, the discovery of bioactive natural products often relied on serendipity, but modern advancements in computational approaches, particularly computer-aided drug design (CADD), have rev

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Anuradha, kumari, Pryanka, kaur walia Manpreet, Abhishek, and singh Nikhil. "Development in natural polymer based drug delivery in transdermal therapeutics." International Journal of Scientific Development and Research 8, no. 8 (2023): 795–800. https://doi.org/10.5281/zenodo.8373814.

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Transdermal drug delivery systems (TDDSs) offer several advantages over other routes of drug administration, contributing to their popularity and utilization in various medical contexts. It offers several advantages, such as non-invasive administration, avoidance of first-pass metabolism, prolonged therapeutic effect, and improved patient compliance. The efficacy and performance of transdermal drug delivery systems can indeed be influenced by various biological factors, which in turn affect the integrity and barrier qualities of the skin. These factors contribute to the variations in the amoun

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Talib, Wamidh H., Ahmad Riyad Alsayed, Muna Barakat, May Ibrahim Abu-Taha, and Asma Ismail Mahmod. "Targeting Drug Chemo-Resistance in Cancer Using Natural Products." Biomedicines 9, no. 10 (2021): 1353. http://dx.doi.org/10.3390/biomedicines9101353.

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Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural produc

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Rani, Yotomi Desia Eka, Mahardian Rahmadi, and Dewi Melani Hariyadi. "Development of natural polymers-based inhaled microspheres for tuberculosis." Pharmacy Education 24, no. 3 (2024): 123–28. http://dx.doi.org/10.46542/pe.2024.243.123128.

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Background: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (Mtb) that mainly affects the lungs (pulmonary TB). Treatment involves a 6-month regimen of four first-line anti-TB drugs: isoniazid (INH), rifampicin (RIF), ethambutol (ETH), and pyrazinamide (PZA). However, the effectiveness of this regimen is limited due to the protection of Mtb bacteria in lung lesions. An alternative approach involves delivering the drugs directly to the lungs through inhalation using innovative methods of microspheres, which can greatly enhance treatment efficacy. Objective: This r

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Al-Awadhi, Fatma H., and Hendrik Luesch. "Targeting eukaryotic proteases for natural products-based drug development." Natural Product Reports 37, no. 6 (2020): 827–60. http://dx.doi.org/10.1039/c9np00060g.

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This review describes the role of natural products as starting points for the development of selective protease inhibitors, examples of approved agents, the clinical and preclinical pipeline, and emerging opportunities beyond classical applications.

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35

Porter, John R. "The Continuing Promise of Natural Products for Drug Development." American Biology Teacher 74, no. 4 (2012): 210–11. http://dx.doi.org/10.1525/abt.2012.74.4.2.

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36

Yan, Wudan. "Going batty: Studying natural reservoirs to inform drug development." Nature Medicine 21, no. 8 (2015): 831–33. http://dx.doi.org/10.1038/nm0815-831.

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37

Muschietti, Liliana, Roser Vila, Valdir Cechinel Filho, and William Setzer. "Tropical Protozoan Diseases: Natural Product Drug Discovery and Development." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–2. http://dx.doi.org/10.1155/2013/404250.

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38

Bauer, Armin, and Mark Brönstrup. "Industrial natural product chemistry for drug discovery and development." Nat. Prod. Rep. 31, no. 1 (2014): 35–60. http://dx.doi.org/10.1039/c3np70058e.

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39

Tsukamoto, Sachiko. "ChemInform Abstract: Study on Natural Products for Drug Development." ChemInform 42, no. 10 (2011): no. http://dx.doi.org/10.1002/chin.201110269.

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Saxena, Sanjai, Manmohan Chhibber, and Inder Pal Singh. "Fungal Bioactive Compounds in Pharmaceutical Research and Development." Current Bioactive Compounds 15, no. 2 (2019): 211–31. http://dx.doi.org/10.2174/1573407214666180622104720.

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Background:Exploration of antibiotics from microorganisms became widespread in the academia and the industry with the serendipitous discovery of Penicillin from Penicillium notatum by Sir Alexander Fleming. This embarked the golden era of antibiotics which lasted for over 60 years. However, the traditional phenotypic screening was replaced with more rational and smarter methods of exploration of bioactive compounds from fungi and microorganisms. Fungi have been responsible for providing a variety of bioactive compounds with diverse activities which have been developed into blockbuster drugs su

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Hammad, Yousaf, jamshaid Muhammad, bashir Irfan, and Mehmood Yasir. "Formulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers." Pharmaceutical Methods 8, no. 1 (2017): 01–09. https://doi.org/10.5281/zenodo.14854471.

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Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity, and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. The overall objective of this work was to

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42

Wamorkar, Vinay, A. Samar, A. Reddy, Anusha Ch, C. V. Saikrishna, and Santoshkumar N. "Development and Evaluation of Novel Floating Drug Delivery Systems of Metoclopramide Hydrochloride." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 3 (2011): 1470–77. http://dx.doi.org/10.37285/ijpsn.2011.4.3.5.

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Several distinct novel drug delivery systems are being employed for effective delivery of medications to patients. Oral delivery is by far the most preferable route of drug delivery and oral sustained-release gastroretentive drug delivery systems offer several advantages. These drug delivery systems are beneficial for drugs with absorption from the upper parts of the gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of these drugs. Floating drug delivery systems (FDDS) are one of the gastroretentive drug delivery systems used to achieve prolonged

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Abhishek, Sahu* Prem Samundre Dr. Jitendra Banweer. "AI in Drug Discovery and Development." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2510–15. https://doi.org/10.5281/zenodo.15426727.

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Artificial intelligence (AI) is revolutionizing the landscape of drug discovery and development by accelerating timelines, reducing costs, and improving the precision of therapeutic design. From target identification to lead optimization and clinical trial design, AI-driven approaches—such as machine learning, deep learning, and natural language processing—are enhancing the efficiency and predictive power of each stage in the pharmaceutical pipeline. This review explores the current applications of AI across the drug development lifecycle, with a focus on virtual screening, de novo

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Xu, Mengwei, Zhaofang Bai, Baocheng Xie, et al. "Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development." Molecules 29, no. 5 (2024): 933. http://dx.doi.org/10.3390/molecules29050933.

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Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than that of other natural derivatives. Currently, there are 20 marine-derived drugs used in clinical practice, with 11 of them demonstrating anti-tumor effects. This article provides a thorough review of recent advancements in anti-tumor exploration involving 167 natural marine bisindole products and their derivatives. Not only has enzastaurin ent

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Wu, Yali, Lulu Pan, Zhendong Chen, Yuandong Zheng, Xingxing Diao, and Dafang Zhong. "Metabolite Identification in the Preclinical and Clinical Phase of Drug Development." Current Drug Metabolism 22, no. 11 (2021): 838–57. http://dx.doi.org/10.2174/1389200222666211006104502.

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Metabolite identification plays a critical role in the phases during drug development. Drug metabolites can contribute to efficacy, toxicity, and drug-drug interaction. Thus, the correct identification of metabolites is essential to understand the behavior of drugs in humans. Drug administration authorities (e.g., FDA, EMA, and NMPA) emphasize evaluating the safety of human metabolites with exposure higher than 10% of the total drugrelated components. Many previous reviews have summarized the various methods, tools, and strategies for the appropriate and comprehensive identification of metabol

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Oselusi, Samson Olaitan, Alan Christoffels, and Samuel Ayodele Egieyeh. "Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds." Molecules 26, no. 13 (2021): 3970. http://dx.doi.org/10.3390/molecules26133970.

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The growing antimicrobial resistance (AMR) of pathogenic organisms to currently prescribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the increasing drug resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have been shown to display promising in vitro activities against multidrug-resistant pathogens. Still, only a few of these compounds have been studied as prospective drug candidates. This may be due to the expensive and time-cons

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47

Handa, Uditi, and Kamal Saroha. "RESEARCH AND DEVELOPMENT OF DIAZEPAM SOLID DISPERSION POWDER USING NATURAL POLYMERS." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 220. http://dx.doi.org/10.22159/ijap.2018v10i5.27975.

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Objective: The objective of this study was to enhance the solubility and dissolution rate of a poorly water-soluble drug by solid dispersion (SD) technique, in order to conduct an investigation of the effect of these natural hydrophilic polymers on release mechanism from SD.Methods: The SD of diazepam (DZM) were prepared by using modified sodium alginate (SA) and modified guar gum (GG) in different drug: polymer ratios (1:1 and 1:2) by using physical mixture method (PM) and fusion method (FM). Further, the formulations were characterized for calibration curve, Fourier transforms infrared spect

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Mukesh Pandey, Madhuri Maher, Mona Semalty, and Ajay Semalty. "Natural Macromolecules in the Development of Safe and Effective Gastroretentive Floating Microparticles of Metformin Hydrochloride." Natural Products Journal 6, no. 1 (2016): 62–72. http://dx.doi.org/10.2174/2210315506999151209101058.

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Background: Metformin hydrochloride, an oral hypoglycaemic, shows better absorption from upper part of the gastric region. Natural/herbal substances have been investigated for the development of natural polymer-based drug delivery systems owing to the desirable properties like biodegradability, biocompatibility, aqueous solubility, swelling ability, easy availability and cost effectiveness. Method: Therefore, three natural macromolecules: Glycine max (soya chunks), Metroxylon sagu (sago starch) and Plantago ovata (psyllium husk) were used for developing its gastroretentive floating micropartic

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Wu, Jianping, Yunheng Li, Qiaojun He, and Xiaochun Yang. "Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment." Molecules 28, no. 3 (2023): 1022. http://dx.doi.org/10.3390/molecules28031022.

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Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which are important sources of drug discovery for tumor treatment. The combination of chemotherapeutic drugs and natural compounds is gradually becoming an important strategy and development direction for tumor treatment. In this paper, we described the role of natural compounds in combination with chemotherapeutic drugs in synergizing, reduci

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Kushwaha, Jeetendra, Dev Sharan Chaturvedi, Manisha Verma, Kuldeep Kumar Tiwari, and Neelesh Anuragi. "FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TABLET TRAZODONE HYDROCHLORIDE USING NATURAL POLYMER." International Research Journal Of Pharmacy 12, no. 8 (2021): 46–51. http://dx.doi.org/10.7897/2230-8407.1208156.

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Abstract:

Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Trazodone Hydrochloride (TRZ) is a well-known chemical compound that is used as an antidepressant that belongs to a selective serotonin reuptake inhibitor (SARI). The objective of present work was to develop and evaluated oral sustained release matrix tablet of TRZ. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight

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