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Dissertations / Theses on the topic 'Neuropeptide Y'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Diez, Margarita. "Neuropeptide expression in mouse disease models /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-514-x/.

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2

Sjödin, Paula. "Pharmacological studies of four neuropeptide Y-family receptor subtypes /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5925.

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3

Pheng, Leng-Hong. "Caractérisation pharmacologique des récepteurs natifs du neuropeptide Y et de la nociceptine." Sherbrooke : Université de Sherbrooke, 2001.

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4

Brumovsky, Pablo R. "Neuropeptides, sensory neurons and pain modulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-442-2/.

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5

Miskelly, I. R. "Comparative analysis of parasitic nematode neuropeptide and neuropeptide receptor encoding genes." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432533.

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6

Guery, Sébastien. "Conception et synthèse de dérivés de l'arginine : Concepts et validation sur des récepteurs de neuropeptides." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/GUERY_Sebastien_2003.pdf.

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La découverte de neuropeptides comme molécules pharmacologiquement actives est d'une importance considérable pour notre compréhension de la neurobiologie. Les neuropeptides peuvent agir en tant que neurotransmetteurs, neuromodulateurs et en tant qu'hormones. Ils contrôlent ou influencent de nombreux types de comportements biologiques (par exemple le comportement sexuel, le comportement alimentaire, la mémoire, l'apprentissage, la perception de la douleur, ). Certains de ces peptides appartiennent à la famille des peptides de type RF-amide qui possèdent dans leur partie C-terminale un résidu Ar

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7

Bjellerup, Per. "Biochemical characterisation and clinical correlation of neuropeptides in neuroblastoma with emphasis on neuropeptide Y /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4524-1/.

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8

Dubin, Thierry. "Le neuropeptide Y dans le phéochromocytome : étude à partir d'une série de 15 cas." Bordeaux 2, 1990. http://www.theses.fr/1990BOR23098.

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9

McVeigh, P. "Neuropeptide signalling in nematodes." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411747.

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10

Morgan, David Alexander. "The role of neuropeptides Y and neuropeptide Y receptors in the control of carbohydrate metabolism." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267076.

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11

Quiroga, Artigas Gonzalo. "Light-induced oocyte maturation in the hydrozoan clytia hemisphaerica." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066284/document.

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Un contrôle précis de la maturation ovocytaire et de la ponte sont essentiels au succès de la reproduction sexuée au sein le règne animal. Ces processus sont coordonnés précisément par des signaux endocriniens et/ou environnementaux, selon les espèces, mais beaucoup reste à apprendre sur leurs régulations. Chez les cnidaires, de nombreuses méduses du groupe des hydrozoaires sont connues pour produire des gamètes en réponse à la transition nuit/jour. Pour caractériser les machineries cellulaires et moléculaires liant la réception de la lumière à l'initiation de la maturation ovocytaire, j'ai ét

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12

Ammar, Ahmed A. "Intake inhibition by neuropeptide Y /." Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-308-6/.

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13

Howell, Owain W. "Neuropeptide Y modulates hippocampal neurogenesis." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403849.

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14

Abusara, Osama. "Neuropeptide antagonists for cancer treatment." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/neuropeptide-antagonists-for-cancer-treatment(e2f22b9f-f0a7-432d-89c4-7e65a2c71b69).html.

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Small Cell Lung Cancer (SCLC) is an aggressive form of cancer accounting for 25% of lung cancer deaths worldwide. Treatment relies on combination chemotherapy (etoposide and cisplatin or carboplatin) with or without radiation therapy. However, disease relapse and resistance occurs quickly, prompting unmet need for alternative treatment options. One such option is the use of broad-spectrum antagonists, known as Substance P (SP) analogues. Historically, these analogues have not succeeded clinically due to low potency and bioavailability. In this project, novel SP analogues were developed to addr

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15

Wong, Kenneth C. "Neuropeptide vascular reactivity in psoriasis." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27706.

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The skin is richly innervated with neuropeptide containing sensory nerve fibres which are involved in cutaneous inflammatory responses and augmentation of inflammation in the axonal reflex. Substance P (SP) and calcitonin generelated peptide (CGRP) are two of the most abundant neuropeptides in the skin. Neuropeptides have been postulated to play a role in the pathogenesis of psoriasis. Evidence to suggest this include: elevated levels of neuropeptides in psoriatic lesions; exacerbation of the disease with stress; improvement of psoriatic lesions with topical capsaicin, which is known to

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16

Morgat, Clément. "Imagerie des récepteurs de neuropeptides pour le ciblage tumoral." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0308/document.

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Des récepteurs de neuropeptides peuvent être fortement exprimés à la surface descellules tumorales offrant ainsi l’opportunité de les visualiser en imagerie par Tomographie d'Emissionde Positons (TEP) grâce à des analogues radiomarqués au 68Ga, 64Cu ou au 18F, mais également desélectionner des patients répondeurs à une radiothérapie métabolique à l'aide de ces mêmes analogues,radiomarqués au 177Lu ou 90Y. Un exemple phare a été le développement d’analogues radiomarqués dela somatostatine pour l'imagerie (68Ga-DOTATOC) et le traitement (177Lu-DOTATATE) des tumeursneuro-endocrines (TNE). Cette v

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17

Ehrström, Marcus. "Studies on the effect of orexin on upper gastrointestinal function in rats and man /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-957-9/.

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18

Dadgar, Anoushiravan. "Studies on rat gastrointestinal neuropeptide Y." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27410.

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A sensitive and specific radioimmunoassay (RIA) for Neuropeptide Y (NPY) was developed and quantitation, characterization and release studies were performed. The development of the RIA required the purification of the NPY tracer due to both multiple iodinated products resulting from the five tyrosine residues in its amino acid sequence, and the presence of unlabelled NPY. Ion-exchange and reverse phase high performance chromatography (HPLC) purification of ¹²⁵I-NPY were performed. Optimal purification of ¹²⁵I-NPY was achieved using a HPLC with a μBondapak C₈ column and a 45-50% acetonitrile c

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19

Poole, Sarah Louise. "Neuropeptide modulation of medullary autonomic circuits." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434147.

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20

Burnet, Philip William John. "Studies on a novel neuropeptide, cerebellin." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47371.

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21

Nunes, Ana Filipa Duarte. "Influence of transthyretin on neuropeptide processing." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7209.

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22

Choi, Yohan. "Neuropeptide Y in early kidney development." Diss., [La Jolla, Calif.] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3344676.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed March 18, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 146-154).

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23

Nunes, Ana Filipa Duarte. "Influence of transthyretin on neuropeptide processing." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7209.

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24

Duroux, Stéphane. "Neuropeptides et muqueuse nasale." Bordeaux 2, 1994. http://www.theses.fr/1994BOR23014.

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25

Phan, Toan Anh. "Ocular immunomodulating neuropeptides alpha-MSH and neuropeptide Y modulate phagocytic activity of the microphage cell line RAW 246.7." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12591.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>The eye is an immune privileged tissue. Within the ocular microenvironment, there are regulatory mechanisms that suppress inflammation. These anti-inflammatory mechanisms are partly mediated by immunomodulating

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26

Eckard, Christophe. "Characterisation of neuropeptide Y receptors by antibodies /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13120.

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27

Fälth, Savitski Maria. "Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9400.

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Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. SwePep can be used for identification and validation of endogenous peptides by comparing experimentally derived masses of peptides and their fragments with information in the database. To improve automatic peptide identification of neuropeptides, targeted sequence collections that better mimic the

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28

Pearce, Craig M. "Central neuropeptide Y control of gastric function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24554.pdf.

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29

Broberger, Christian. "Neuropeptide circuitries regulating food and water intake /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3625-0/.

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30

Price, John Stephen. "Receptor binding and metabolism of neuropeptide Y." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335180.

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31

Hamdan, Suhail A. El-Ghani. "The neuropeptide ACTH and the immune system." Thesis, University of Strathclyde, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366747.

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32

Lin, Ming. "Identification and functional characterization of relaxin-type and pedal peptide/orcokinin-type neuropeptides in the starfish Asterias rubens." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/30715.

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Neuropeptides are neuronal signaling molecules that regulate many physiological and behavioural processes in vertebrates and invertebrates. Investigation of neuropeptide signaling in echinoderms (e.g. starfish) can provide insights into the evolution of neuropeptide systems because as deuterostomian invertebrates they occupy an "intermediate" phylogenetic position between vertebrates and protostomian invertebrates. Recent analysis of neural transcriptome data from the starfish Asterias rubens has identified 40 transcripts encoding neuropeptide precursors. Here the expression and function of ne

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33

Xu, Isabella Shi. "The role of neuropeptides in spinal nociceptive mechanisms with special emphasis on galanin, neuropeptide Y and orphanin FQ/nociceptin /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3973-X/.

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34

Pickavance, Lucy Cecilia. "Somatostatin, neuropeptide Y and galanin: Immunohistochemical detection and mapping of neuropeptide distributions in goldfish brain, with reference to rat." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/5626.

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The biochemical neuroanatomy of the goldfish brain, with some reference to that in the rat brain, was investigated. Retrograde tracing immunofluorescence techniques reveal that the efferents of the somatostatin (SRIF)-positive cells of the entopeduncular nucleus of the rat do not project to the ventroanterior/ventrolateral nuclei of the thalamus. Using of immunohistochemical staining techniques, the distributions of the neurotransmitters SRIF, NPY and galanin (Gal) were mapped throughout the brain of the goldfish. Single-label immunohistochemistry was used to determine the distribution of Gal

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35

Guo, Ningning. "GSH : a new candidate neuropeptide in the CNS." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29856.

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The physiological significance of glutathione (GSH) in the mammalian central nervous system is still uncertain, although some evidence has indicated that GSH may play an important role in the CNS. To address the question of whether GSH may be a candidate for a neuropeptide in the CNS, one step is to establish that GSH receptors are present. In the present study, biotinyl-GSH was synthesized and purified to detect the GSH receptor in the CNS. Histochemical experiments showed that GSH binding sites appeared on the white matter ( such as cingulum, dorsal hippocampal commissure, cerebral peduncl

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36

Salaneck, Erik. "Molecular Evolution of Neuropeptide Y Receptors in Vertebrates." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4988-3/.

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37

Zachrisson, Olof. "On the neuropeptide mRNA expression following neuropsychopharmacological treatments /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980925zach.

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38

Morales, Medina Julio. "Role of neuropeptide Y in emotional dysfunctional conditions." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107774.

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Anxiety and depression are two highly debilitating disorders with high prevalence and co-morbidity with other mental and physical disorders. Current available treatments for these diseases present major caveats, thus the search for novel targets of treatment are the foremost challenges in health research. In this regard, the neuropeptide Y (NPY) system has emerged as a neuromodulator of emotional processing. This peptide mediates its effects by acting on its Y1, Y2 and Y5 receptor subtypes in the brain. However the contribution of each receptor subtype in emotional processes is still not clear

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39

Chaloin, Olivier. "Synthèse d'analogues peptidiques et pseudopeptidiques du neuropeptide Y." Montpellier 2, 1996. http://www.theses.fr/1996MON20100.

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Ce travail est consacre a la synthese d'analogues peptidiques et pseudopeptidiques du neuropeptide y. Une etude sur les relations structure-activite a ete developpee. Dans un premier temps, nous avons synthetise des analogues modifies au niveau du pentapeptide c terminal par des substitutions d'aminoacides et introduction de liaisons pseudopeptidiques. Dans une deuxieme partie, nous avons synthetise des analogues dimerises de la partie c terminale du neuropeptide y. La derniere partie de ce travail a ete la synthese d'analogues du bibp 3226, un puissant antagoniste selectif des recepteurs y1 d

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40

GELOT, AGATHE. "Neuropeptide ff et nociception ; role des systemes opioides." Toulouse 3, 1998. http://www.theses.fr/1998TOU30190.

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Les systeme neuropeptide ff (npff) est un systeme neuronal a part entiere compose de voies neuronales et de recepteurs specifiques. Le npff module les sytemes opioides de facon complexe, activites pro- ou anti-opioides, suivant des modalites encore peu connues. Le but de ce travail est de caracteriser le systeme npff au plan pharmacologique chez la souris a l'aide de deux analogues ayant des proprietes differentes et d'etudier ses modalites de fonctionnement chez des animaux traitees chroniquement par les opioides. Pour cela nous avons recherche 1) les relations entre le npff et differents typ

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41

Marco, Heather G. "Neuropeptide hormones from the eyestalks of Jasus Lalandii." Doctoral thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/7692.

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Bibliography: p. 242-264.<br>The X-organ sinus gland complex, situated in the eyestalks of decapod crustaceans, are known to be a source of a variety of neuropeptide hormones that regulate a number of diverse physiological processes. This neuroendocrine complex was investigated in 3 crustacean species, viz. the European shore crab Carcinus maellas, and 2 spiny lobster species Jasus lalandii and Panulirus homarus by means of tissue immunocytochemistry and an enzyme-linked immunosorbent assay (ELISA). Positive immunoreactions, associated with the X-organ - sinus gland system only, were obtained

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42

EATON, KATHERINE L. "NEUROPEPTIDE RECEPTORS IN THE AMYGDALA: RELEVANCE TO STRESS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1193098999.

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43

Eaton, Katherine L. "Neuropeptide receptors in the amygdala relevance to stress /." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc//view?acc_num=ucin1193098999.

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Thesis (Ph.D.)--University of Cincinnati, 2007.<br>Advisor: Dr. Floyd R Sallee. Title from electronic thesis title page (viewed Mar. 29, 2009). Keywords: amygdala; neuropeptide; NPY receptor; CRH receptor; chronic stress; glucocorticoid; GIR. Includes abstract. Includes bibliographical references.

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44

Krause, Katharina Isabelle [Verfasser]. "Neuropeptide und Lipide der Haut / Katharina Isabelle Krause." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023817861/34.

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45

DEL, ZOPPO Luisa. "Analoghi del Neuropeptide S modificati in posizione 5." Doctoral thesis, Università degli studi di Ferrara, 2013. http://hdl.handle.net/11392/2388923.

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Neuropeptide S (NPS) is the last neuropeptide identified via Reverse Pharmacology techniques. NPS selectively binds and activates a previously orphan GPCR 154, now named NPSR, producing intracellular calcium mobilization and cAMP levels. Biological functions modulated by the NPS/NPSR system include anxiety, arousal, locomotion, food intake, memory, and drug addiction. The primary sequence of NPS (in humans SFRNGVGTGMKKTSFQRAKS) is highly conserved among vertebrates especially at the N-terminus. Ala- and D-scan together with truncation studies demonstrated that the N-teminal sequence of t

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46

Nagy, Dóra. "Peptidergic control of dormancy in Drosophila melanogaster." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426310.

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Organisms, especially those living in temperate zones, are constantly exposed to the cyclical changes of environmental factors due to the alternating seasons. In order to increase their chances of survival, they evolved different adaptive mechanisms to withstand the stress of harsh periods. Among insects, diapause is the most commonly used strategy to achieve seasonal synchronization. Diapause is a neuro-hormonally regulated state of dormancy that enables insects to switch to an alternative developmental program when external conditions are not suitable for normal development. In the fruit f

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47

Chan, Pui-shan. "Effects of NPY-Y1 receptor activation or inhibition on free radical generation during in vitro or in vivo cerebral ischemia." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B35760825.

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48

Sickinger, Marlene. "Neuropeptidgehalt der bovinen Labmagenwand in Abhängigkeit von Rasse und Verlagerungszustand." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4790/index.html.

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49

Spada, Janek, Christian Sander, Ralph Burkhardt, et al. "Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-144927.

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Background: The neuropeptide S receptor (NPSR1) and its ligand neuropeptide S (NPS) have received increased attention in the last few years, as both establish a previously unknown system of neuromodulation. Animal research studies have suggested that NPS may be involved in arousal/wakefulness and may also have a crucial role in sleep regulation. The single nucleotide polymorphism (SNP) rs324981 in NPSR1 has begun to shed light on a function of the NPS-system in human sleep regulation. Due to an amino acid exchange, the T-allele leads to an increased sensitivity of the NPSR1. In the only genome

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50

Stricker-Krongrad, Alain. "Recherches sur les fonctions orexigenes du neuropeptide y cérébral." Nancy 1, 1993. http://www.theses.fr/1993NAN10385.

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Le contrôle du comportement alimentaire est le résultat de l'intégration dans le système nerveux central d'informations multiples. Le système constitué du noyau arque et du noyau paraventriculaire est un circuit intrahypothalamique à neuropeptide y implique dans la régulation de la préférence alimentaire et de l'hyperphagie. La mise en évidence d'une libération de neuropeptide y dans ce dernier noyau montre que son action centrale peut être comprise comme associée et non pas dépendante des circuits monoaminergiques cérébraux dans la mise en œuvre des phénomènes impliques dans les fonctions ore

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