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Journal articles on the topic 'Neuropeptide Y'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Veenstra, Jan A. "Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species." PeerJ 7 (June 17, 2019): e7144. http://dx.doi.org/10.7717/peerj.7144.

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Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence

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2

Southey, Bruce R., and Sandra L. Rodriguez-Zas. "Changes in Neuropeptide Prohormone Genes among Cetartiodactyla Livestock and Wild Species Associated with Evolution and Domestication." Veterinary Sciences 9, no. 5 (2022): 247. http://dx.doi.org/10.3390/vetsci9050247.

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The impact of evolution and domestication processes on the sequences of neuropeptide prohormone genes that participate in cell–cell signaling influences multiple biological process that involve neuropeptide signaling. This information is important to understand the physiological differences between Cetartiodactyla domesticated species such as cow, pig, and llama and wild species such as hippopotamus, giraffes, and whales. Systematic analysis of changes associated with evolutionary and domestication forces in neuropeptide prohormone protein sequences that are processed into neuropeptides was un

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Pidsudko, Z., J. Kaleczyc, J. Zmudzki, et al. "Changes in the tissue concentrations of several neuropeptides in porcine intestines and intestine-innervating ganglia in the course of porcine proliferative enteropathy." Veterinární Medicína 63, No. 5 (2018): 210–15. http://dx.doi.org/10.17221/62/2017-vetmed.

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Inflammatory processes are associated with changes in the interplay of different pro- and anti-inflammatory factors, including neuropeptides, in tissue. This study was performed to investigate the influence of proliferative enteropathy on the concentration of several neuropeptides known to be involved in the regulation of the inflammatory process in porcine intestine and intestine-innervating ganglia. The concentration of galanin, vasoactive intestinal polypeptide, somatostatin, neuropeptide Y, substance P and calcitonin gene-related peptide were assayed with ELISA in the coeliac-superior mese

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Avgan, Nesli, Heidi G. Sutherland, Rod A. Lea, Larisa M. Haupt, David H. K. Shum, and Lyn R. Griffiths. "Association Study of a Comprehensive Panel of Neuropeptide-Related Polymorphisms Suggest Potential Roles in Verbal Learning and Memory." Genes 15, no. 1 (2023): 30. http://dx.doi.org/10.3390/genes15010030.

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Neuropeptides are mostly expressed in regions of the brain responsible for learning and memory and are centrally involved in cognitive pathways. The majority of neuropeptide research has been performed in animal models; with acknowledged differences between species, more research into the role of neuropeptides in humans is necessary to understand their contribution to higher cognitive function. In this study, we investigated the influence of genetic polymorphisms in neuropeptide genes on verbal learning and memory. Variants in genes encoding neuropeptides and neuropeptide receptors were tested

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Zandawala, Meet, Ismail Moghul, Luis Alfonso Yañez Guerra, et al. "Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms." Open Biology 7, no. 9 (2017): 170129. http://dx.doi.org/10.1098/rsob.170129.

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Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae , Amphiura filiformis and Ophiopsila aranea , has enabled the first comprehensive identification of neu

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Semmens, Dean C., Isabel Beets, Matthew L. Rowe, Liisa M. Blowes, Paola Oliveri, and Maurice R. Elphick. "Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family." Open Biology 5, no. 4 (2015): 150030. http://dx.doi.org/10.1098/rsob.150030.

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Neuropeptides are ancient regulators of physiology and behaviour, but reconstruction of neuropeptide evolution is often difficult owing to lack of sequence conservation. Here, we report that the receptor for the neuropeptide NGFFFamide in the sea urchin Strongylocentrotus purpuratus (phylum Echinodermata) is an orthologue of vertebrate neuropeptide-S (NPS) receptors and crustacean cardioactive peptide (CCAP) receptors. Importantly, this has facilitated reconstruction of the evolution of two bilaterian neuropeptide signalling systems. Genes encoding the precursor of a vasopressin/oxytocin-type

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Ryznar, Rebecca, Nathan Andrews, Kyle Emery, et al. "Specific Salivary Neuropeptides Shift Synchronously during Acute Stress in Fire Recruits." Brain Sciences 14, no. 5 (2024): 492. http://dx.doi.org/10.3390/brainsci14050492.

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Once thought of as an immune-privileged site, we now know that the nervous system communicates in a bidirectional manner with the immune system via the neuroimmune axis. Neuropeptides constitute a component of this axis, playing critical roles in the brain and periphery. The function of salivary neuropeptides in the acute stress response is not well understood. The purpose of this study is to investigate salivary neuropeptide levels during acute stress. Salivary samples were collected from fire recruits engaged in a stress training exercise previously shown to induce acute stress, at three sep

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Wang, Zhengbing, Wenwu Zhou, Muhammad Hameed, Jiali Liu, and Xinnian Zeng. "Characterization and Expression Profiling of Neuropeptides and G-Protein-Coupled Receptors (GPCRs) for Neuropeptides in the Asian Citrus Psyllid, Diaphorina citri (Hemiptera: Psyllidae)." International Journal of Molecular Sciences 19, no. 12 (2018): 3912. http://dx.doi.org/10.3390/ijms19123912.

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Neuropeptides are endogenous active substances that widely exist in multicellular biological nerve tissue and participate in the function of the nervous system, and most of them act on neuropeptide receptors. In insects, neuropeptides and their receptors play important roles in controlling a multitude of physiological processes. In this project, we sequenced the transcriptome from twelve tissues of the Asian citrus psyllid, Diaphorina citri Kuwayama. A total of 40 candidate neuropeptide genes and 42 neuropeptide receptor genes were identified. Among the neuropeptide receptor genes, 35 of them

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Zhang, Long, Lichao Sun, Guanghao Song, et al. "Genome-Wide Identification and Expression of Neuropeptides and Their Expression Patterns After RNAi of CHH Genes in Pacific White Shrimp Litopenaeus vannamei." Biology 13, no. 12 (2024): 1038. https://doi.org/10.3390/biology13121038.

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Neuropeptides are pivotal in regulating a broad spectrum of developmental, physiological, and behavioral processes throughout the life cycle of crustaceans. In this comprehensive study, we utilized a multiomics approach to characterize neuropeptide precursors and to assess the expression profiles of neuropeptide-encoding genes across various tissues and developmental stages in the Pacific white shrimp, Litopenaeus vannamei. Additionally, we explored the differential expression of neuropeptide genes in the eyestalk before and after the RNA interference-mediated suppression of crustacean hypergl

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Veenstra, Jan A. "Similarities between decapod and insect neuropeptidomes." PeerJ 4 (May 26, 2016): e2043. http://dx.doi.org/10.7717/peerj.2043.

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Background.Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts.Methods.The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed t

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Shiraishi, Akira, Toshimi Okuda, Natsuko Miyasaka, et al. "Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides." Proceedings of the National Academy of Sciences 116, no. 16 (2019): 7847–56. http://dx.doi.org/10.1073/pnas.1816640116.

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Neuropeptides play pivotal roles in various biological events in the nervous, neuroendocrine, and endocrine systems, and are correlated with both physiological functions and unique behavioral traits of animals. Elucidation of functional interaction between neuropeptides and receptors is a crucial step for the verification of their biological roles and evolutionary processes. However, most receptors for novel peptides remain to be identified. Here, we show the identification of multiple G protein-coupled receptors (GPCRs) for species-specific neuropeptides of the vertebrate sister group, Ciona

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Liu, Yining, and Min Zhao. "Decode the Stable Cell Communications Based on Neuropeptide-Receptors Network in 36746 Tumor Cells." Biomedicines 10, no. 1 (2021): 14. http://dx.doi.org/10.3390/biomedicines10010014.

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Background: As chemical signals of hormones, neuropeptides are essential to regulate cell growth by interacting with their receptors to achieve cell communications in cancer tissues. Previously, neuropeptide transcriptome analysis was limited to tissue-based bulk expression levels. The molecular mechanisms of neuropeptides and their receptors at the single-cell level remain unclear. We conducted a systematic single-cell transcriptome data integration analysis to clarify the similarities and variations of neuropeptide-mediated cell communication between various malignancies. Methods: Based on t

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Zheng, Yingqiu, Xiao Cong, Huachen Liu, Yixin Wang, Kenneth B. Storey, and Muyan Chen. "Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus." Biology 11, no. 10 (2022): 1538. http://dx.doi.org/10.3390/biology11101538.

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Here, we described the complex nervous system at five early developmental stages (blastula, gastrula, auricularia, doliolaria and pentactula) of a holothurian species with highly economic value, Apostichopus japonicus. The results revealed that the nervous system of embryos and larvae is mainly distributed in the anterior apical region, ciliary bands or rings, and the feeding and attachment organs, and that serotonergic immunoreactivity was not observed until the embryo developed into the late gastrula; these are evolutionarily conserved features of echinoderm, hemichordate and protostome larv

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Lei, Quanxing, Ziming Wang, Shuangyan Yao, et al. "Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted Ladybird Henosepilachna vigintioctopunctata." Insects 16, no. 6 (2025): 624. https://doi.org/10.3390/insects16060624.

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The ladybird beetle, Henosepilachna vigintioctopunctata, is an oligophagous pest with significant economic impact. This pest causes considerable economic damage on numerous Solanaceae crops. Neuropeptides, along with their designated receptors, play a pivotal role in regulating diverse biological processes in insects, presenting a promising avenue for innovative pest management strategies. Herein, the transcriptome of the central nervous system (CNS) of H. vigintioctopunctata was sequenced. Overall, our analysis identified 58 neuropeptide precursor genes, from which 98 diverse mature peptides

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Mateos-Hernández, Lourdes, Natália Pipová, Eléonore Allain, et al. "Enlisting the Ixodes scapularis Embryonic ISE6 Cell Line to Investigate the Neuronal Basis of Tick—Pathogen Interactions." Pathogens 10, no. 1 (2021): 70. http://dx.doi.org/10.3390/pathogens10010070.

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Neuropeptides are small signaling molecules expressed in the tick central nervous system, i.e., the synganglion. The neuronal-like Ixodes scapularis embryonic cell line, ISE6, is an effective tool frequently used for examining tick–pathogen interactions. We detected 37 neuropeptide transcripts in the I. scapularis ISE6 cell line using in silico methods, and six of these neuropeptide genes were used for experimental validation. Among these six neuropeptide genes, the tachykinin-related peptide (TRP) of ISE6 cells varied in transcript expression depending on the infection strain of the tick-born

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Josefsson, Malin, Magnus Becker, Fritz Stroman, Daniel G. Brenner, and Göran Petersson. "Effect of Recombinant Neutral Endopeptidase (EC 3.4.24.11) on Neuropeptide-Mediated Nasal Fluid Secretion and Plasma Exudation in the Rat." American Journal of Rhinology 12, no. 2 (1998): 135–42. http://dx.doi.org/10.2500/105065898781390244.

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The nasal mucosa harbors sensory nerves containing neuropeptides such as substance P (SP), which are released by capsaicin. The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa. We studied the effect of enzymatically active recombinant NEP (rNEP) on neuropeptide-evoked secretion of nasal fluid and plasma exudation in rats. rNEP administered intranasally (i.n.) reduced the capsaicin-evoked nasal fluid secretion but failed to reduce the secretion evoked by SP (exogenous) under the experimental conditions used. rNEP reduced the increa

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Kong, Xue, Zhen-Xiang Li, Yu-Qing Gao, et al. "Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp, Aphidius gifuensi." Insects 12, no. 8 (2021): 745. http://dx.doi.org/10.3390/insects12080745.

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In insects, neuropeptides and their receptors not only play a critical role in insect physiology and behavior but also are the potential targets for novel pesticide discoveries. Aphidius gifuensis is one of the most important and widespread aphid parasitoids, and has been successfully used to control aphid. In the present work, we systematically identified neuropeptides and their receptors from the genome and head transcriptome of A. gifuensis. A total of 35 neuropeptide precursors and 49 corresponding receptors were identified. The phylogenetic analyses demonstrated that 35 of these receptors

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Fehér, Erzsébet. "Neuropeptid Y és P anyag immunreaktív idegrostok és immunkompetens sejtek változása hepatitisben." Orvosi Hetilap 156, no. 47 (2015): 1892–97. http://dx.doi.org/10.1556/650.2015.30300.

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Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes. In hepatitis the number of both neuropeptide Y and substance P immunoreactive nerve fibres are increased, where the increase of neoropeptide Y is significant. A large number of lymphocytes and mast cells are also stained for neuropeptide Y and substance P. Very close associations (less than 1 µm) were observed between neuropeptide Y immunoreactive nerve fibres and immune cells stained also with neuropeptide Y. Some immune cells were also

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Bodea, Alina, and Amorin Remus Popa. "Orectic And Anorectic Peptides And Their Implication In Obesity And The Metabolic Syndrome." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 22, no. 2 (2015): 187–91. http://dx.doi.org/10.1515/rjdnmd-2015-0023.

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AbstractBackground and aims: Cardiovascular diseases, diabetes mellitus, the metabolic syndrome and obesity are now globally widespread clinical conditions, addressing different ages, lately extending to young and children. The causes are multiple, involving an interaction between individual genetic risk factors and environmental factors. Many studies showed the importance of the hypothalamic neuropeptides and other neuropeptides in the regulation of the balance between food intake and energy consumption. We reviewed 25 recent research studies describing the physiological and physiopathologica

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Li, Honghao, Liangzhen Jiang, Kaixiang Yang, Shulin Shang, Mingxin Li, and Zhibin Lv. "iNP_ESM: Neuropeptide Identification Based on Evolutionary Scale Modeling and Unified Representation Embedding Features." International Journal of Molecular Sciences 25, no. 13 (2024): 7049. http://dx.doi.org/10.3390/ijms25137049.

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Neuropeptides are biomolecules with crucial physiological functions. Accurate identification of neuropeptides is essential for understanding nervous system regulatory mechanisms. However, traditional analysis methods are expensive and laborious, and the development of effective machine learning models continues to be a subject of current research. Hence, in this research, we constructed an SVM-based machine learning neuropeptide predictor, iNP_ESM, by integrating protein language models Evolutionary Scale Modeling (ESM) and Unified Representation (UniRep) for the first time. Our model utilized

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Vörös, Imre, Zsófia Onódi, Viktória Éva Tóth, et al. "Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone." Biomedicines 10, no. 7 (2022): 1573. http://dx.doi.org/10.3390/biomedicines10071573.

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Dipeptidyl-peptidase-4 (DPP4) inhibitors are novel medicines for diabetes. The SAVOR-TIMI-53 clinical trial revealed increased heart-failure-associated hospitalization in saxagliptin-treated patients. Although this side effect could limit therapeutic use, the mechanism of this potential cardiotoxicity is unclear. We aimed to establish a cellular platform to investigate DPP4 inhibition and the role of its neuropeptide substrates substance P (SP) and neuropeptide Y (NPY), and to determine the expression of DDP4 and its neuropeptide substrates in the human heart. Western blot, radio-, enzyme-link

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Klose, Markus K., Marcel P. Bruchez, David L. Deitcher, and Edwin S. Levitan. "Temporally and spatially partitioned neuropeptide release from individual clock neurons." Proceedings of the National Academy of Sciences 118, no. 17 (2021): e2101818118. http://dx.doi.org/10.1073/pnas.2101818118.

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Neuropeptides control rhythmic behaviors, but the timing and location of their release within circuits is unknown. Here, imaging in the brain shows that synaptic neuropeptide release by Drosophila clock neurons is diurnal, peaking at times of day that were not anticipated by prior electrical and Ca2+ data. Furthermore, hours before peak synaptic neuropeptide release, neuropeptide release occurs at the soma, a neuronal compartment that has not been implicated in peptidergic transmission. The timing disparity between release at the soma and terminals results from independent and compartmentalize

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Hsu, I.-Uen, Jeremy W. Linsley, Xiaoli Zhang, et al. "Stac protein regulates release of neuropeptides." Proceedings of the National Academy of Sciences 117, no. 47 (2020): 29914–24. http://dx.doi.org/10.1073/pnas.2009224117.

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Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca2+. However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca2+channels (CaChs) and excitation–contraction coupling in vertebrate skeletal muscles. There is a small family ofstacgenes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood.Dros

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Lestanova, Z., Z. Bacova, and Jan Bakos. "Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview." Endocrine Regulations 50, no. 2 (2016): 72–82. http://dx.doi.org/10.1515/enr-2016-0011.

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AbstractThe present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particul

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Muschter, Dominique, Anna-Sophie Beiderbeck, Tanja Späth, Christian Kirschneck, Agnes Schröder, and Susanne Grässel. "Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages." International Journal of Molecular Sciences 20, no. 3 (2019): 503. http://dx.doi.org/10.3390/ijms20030503.

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This study aimed to analyze if the sensory neuropeptide SP (SP) and the neurokinin receptor 1 (NK1R) are involved in macrophage mechano-transduction, similar to chondrocytes, and if alpha-calcitonin gene-related peptide (αCGRP) and the CGRP receptor (CRLR/Ramp1) show comparable activity. Murine RAW264.7 macrophages were subjected to a cyclic stretch for 1–3 days and 4 h/day. Loading and neuropeptide effects were analyzed for gene and protein expression of neuropeptides and their receptors, adhesion, apoptosis, proliferation and ROS activity. Murine bone marrow-derived macrophages (BMM) were is

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Josef, Troger. "Neuropeptide Research in the Eye." Journal of Clinical Research and Ophthalmology 2, no. 2 (2015): 030. https://doi.org/10.17352/2455-1414.000015.

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The neuropeptide research in the eye is the main topic of our scientific group in Innsbruck. Most of the neuropeptides have been discovered more than 30 years ago and the presence and distribution of some of them has been explored in the eye in the 80´s mainly by Richard Stone. This concerns particularly substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Whereas SP and CGRP have been found to be constituents of the sensory innervation of the eye, VIP is present in the parasympathetic and NPY in the sympathetic inner

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Ma, Tianlu, Shinya Matsuoka, and Daniela Drummond-Barbosa. "RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance." PLOS ONE 15, no. 12 (2020): e0243756. http://dx.doi.org/10.1371/journal.pone.0243756.

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Reproduction is highly sensitive to changes in physiology and the external environment. Neuropeptides are evolutionarily conserved signaling molecules that regulate multiple physiological processes. However, the potential reproductive roles of many neuropeptide signaling pathways remain underexplored. Here, we describe the results of RNAi-based screens in Drosophila melanogaster to identify neuropeptides/neuropeptide receptors with potential roles in oogenesis. The screen read-outs were either the number of eggs laid per female per day over time or fluorescence microscopy analysis of dissected

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Colmers, William F., and Bouchaïb El Bahh. "Neuropeptide Y and Epilepsy." Epilepsy Currents 3, no. 2 (2003): 53–58. http://dx.doi.org/10.1111/j.1535-7597.2003.03208.x.

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It is a central tenet of the epilepsy field that seizures result from the imbalance of excitation over inhibition ( 1 ). The bulk of excitation is mediated by the neurotransmitter glutamate, whereas inhibition results mainly from the actions of γ-aminobutyric acid (GABA). In the neocortex and hippocampus, the intrinsic sources of GABA are the interneurons, which lately have come under intense scrutiny. It has become clear that a large number of distinct types of interneurons can be differentiated in part by the array of neuropeptides they coexpress (cf. 2). Evidence is emerging that the neurop

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DARMER, Dorothea, Frank HAUSER, Hans-Peter NOTHACKER, Thomas C. G. BOSCH, Michael WILLIAMSON, and Cornelis J. P. GRIMMELIKHUIJZEN. "Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata." Biochemical Journal 332, no. 2 (1998): 403–12. http://dx.doi.org/10.1042/bj3320403.

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The freshwater polyp Hydra is the most frequently used model for the study of development in cnidarians. Recently we isolated four novel Arg-Phe-NH2 (RFamide) neuropeptides, the Hydra-RFamides I–IV, from Hydra magnipapillata. Here we describe the molecular cloning of three different preprohormones from H. magnipapillata, each of which gives rise to a variety of RFamide neuropeptides. Preprohormone A contains one copy of unprocessed Hydra-RFamide I (QWLGGRFG), II (QWFNGRFG), III/IV [(KP)HLRGRFG] and two putative neuropeptide sequences (QLMSGRFG and QLMRGRFG). Preprohormone B has the same genera

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Lee, James Siho, Pei-Yin Shih, Oren N. Schaedel, Porfirio Quintero-Cadena, Alicia K. Rogers, and Paul W. Sternberg. "FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system." Proceedings of the National Academy of Sciences 114, no. 50 (2017): E10726—E10735. http://dx.doi.org/10.1073/pnas.1710374114.

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Animals, including humans, can adapt to environmental stress through phenotypic plasticity. The free-living nematode Caenorhabditis elegans can adapt to harsh environments by undergoing a whole-animal change, involving exiting reproductive development and entering the stress-resistant dauer larval stage. The dauer is a dispersal stage with dauer-specific behaviors for finding and stowing onto carrier animals, but how dauers acquire these behaviors, despite having a physically limited nervous system of 302 neurons, is poorly understood. We compared dauer and reproductive development using whole

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Chandrasekharan, Bindu, Behtash Ghazi Nezami, and Shanthi Srinivasan. "Emerging neuropeptide targets in inflammation: NPY and VIP." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 11 (2013): G949—G957. http://dx.doi.org/10.1152/ajpgi.00493.2012.

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The enteric nervous system (ENS), referred to as the “second brain,” comprises a vast number of neurons that form an elegant network throughout the gastrointestinal tract. Neuropeptides produced by the ENS play a crucial role in the regulation of inflammatory processes via cross talk with the enteric immune system. In addition, neuropeptides have paracrine effects on epithelial secretion, thus regulating epithelial barrier functions and thereby susceptibility to inflammation. Ultimately the inflammatory response damages the enteric neurons themselves, resulting in deregulations in circuitry an

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Cadena-Caballero, Cristian E., Nestor Munive-Argüelles, Lina M. Vera-Cala, et al. "APGW/AKH Precursor from Rotifer Brachionus plicatilis and the DNA Loss Model Explain Evolutionary Trends of the Neuropeptide LWamide, APGWamide, RPCH, AKH, ACP, CRZ, and GnRH Families." Journal of Molecular Evolution 91, no. 6 (2023): 882–96. http://dx.doi.org/10.1007/s00239-023-10146-9.

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AbstractIn the year 2002, DNA loss model (DNA-LM) postulated that neuropeptide genes to emerged through codons loss via the repair of damaged DNA from ancestral gene namely Neuropeptide Precursor Predictive (NPP), which organization correspond two or more neuropeptides precursors evolutive related. The DNA-LM was elaborated according to amino acids homology among LWamide, APGWamide, red pigment-concentrating hormone (RPCH), adipokinetic hormones (AKHs) and in silico APGW/RPCH NPPAPGW/AKH NPP were proposed. With the above principle, it was proposed the evolution of corazonin (CRZ), gonadotropin

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Sun, Changsheng, Jiatong Han, Yixin Bai, Zhaowei Zhong, Yingtao Song, and Yu Sun. "Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder." Disease Markers 2021 (October 21, 2021): 1–13. http://dx.doi.org/10.1155/2021/3683189.

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Background. The aim of this study was at investigating the association between major depressive disorder (MDD) and periodontitis based on crosstalk genes and neuropeptides. Methods. Datasets for periodontitis (GSE10334, GSE16134, and GSE23586) and MDD (GSE38206 and GSE39653) were downloaded from GEO. Following batch correction, a differential expression analysis was applied (MDD: ∣ log 2 FC ∣ > 0 and periodontitis ∣ log 2 FC ∣ ≥ 0.5 , p < 0.05 ). The neuropeptide data were downloaded from NeuroPep and NeuroPedia. Intersected genes were potential crosstalk genes. The correlation between n

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Kaur, Rimanpreet, Naina Arora, Meera G. Nair, and Amit Prasad. "The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation." Biochemical Society Transactions 50, no. 1 (2022): 107–18. http://dx.doi.org/10.1042/bst20210405.

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Neuropeptides comprise a diverse and broad group of neurotransmitters in vertebrates and invertebrates, with critical roles in neuronal signal transduction. While their role in controlling learning and memory in the brains of mammals is known, their extra-synaptic function in infection and inflammation with effects on distinct tissues and immune cells is increasingly recognized. Helminth infections especially of the central nervous system (CNS), such as neurocysticercosis, induce neuropeptide production by both host and helminth, but their role in host–parasite interplay or host inflammatory r

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Chalmers, John, Vimal Kapoor, Eric Mills, et al. "Do pressor neurons in the ventrolateral medulla release amines and neuropeptides?" Canadian Journal of Physiology and Pharmacology 65, no. 8 (1987): 1598–604. http://dx.doi.org/10.1139/y87-251.

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Activation of neurons arising in the rostral ventrolateral medulla evokes a pressor response in the rat and the rabbit. This region of the medulla gives rise to bulbospinal neurons containing many different neurotransmitters, including amines such as adrenaline, noradrenaline and serotonin, and neuropeptides such as substance P and neuropeptide Y. Colocalization of amines and neuropeptides has been described in some neurons descending from the rostral ventrolateral medulla. In this paper we discuss the evidence that bulbospinal serotonin-containing neurons (B3) and adrenaline-containing neuron

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Nosova, Olga, Igor Bazov, Victor Karpyak, Mathias Hallberg, and Georgy Bakalkin. "Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain." Molecules 26, no. 11 (2021): 3458. http://dx.doi.org/10.3390/molecules26113458.

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Neuropeptides serve as neurohormones and local paracrine regulators that control neural networks regulating behavior, endocrine system and sensorimotor functions. Their expression is characterized by exceptionally restricted profiles. Circuit-specific and adaptive expression of neuropeptide genes may be defined by transcriptional and epigenetic mechanisms controlled by cell type and subtype sequence-specific transcription factors, insulators and silencers. The opioid peptide dynorphins play a critical role in neurological and psychiatric disorders, pain processing and stress, while their mutat

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Taghert, Paul H. "FMRFamide neuropeptides and neuropeptide-associated enzymes inDrosophila." Microscopy Research and Technique 45, no. 2 (1999): 80–95. http://dx.doi.org/10.1002/(sici)1097-0029(19990415)45:2<80::aid-jemt3>3.0.co;2-x.

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Sharma, Suresh D., Gayatri Raghuraman, Myeong-Seon Lee, Nanduri R. Prabhakar та Ganesh K. Kumar. "Intermittent hypoxia activates peptidylglycine α-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing". Journal of Applied Physiology 106, № 1 (2009): 12–19. http://dx.doi.org/10.1152/japplphysiol.90702.2008.

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Intermittent hypoxia (IH) associated with sleep apneas leads to cardiorespiratory abnormalities that may involve altered neuropeptide signaling. The effects of IH on neuropeptide synthesis have not been investigated. Peptidylglycine α-amidating monooxygenase (PAM; EC 1.14.17.3) catalyzes the α-amidation of neuropeptides, which confers biological activity to a large number of neuropeptides. PAM consists of O2-sensitive peptidylglycine α-hydroxylating monooxygenase (PHM) and peptidyl-α-hydroxyglycine α-amidating lyase (PAL) activities. Here, we examined whether IH alters neuropeptide synthesis b

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Schéle, Erik, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, and John-Olov Jansson. "The Gut Microbiota Reduces Leptin Sensitivity and the Expression of the Obesity-Suppressing Neuropeptides Proglucagon (Gcg) and Brain-Derived Neurotrophic Factor (Bdnf) in the Central Nervous System." Endocrinology 154, no. 10 (2013): 3643–51. http://dx.doi.org/10.1210/en.2012-2151.

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The gut microbiota contributes to fat mass and the susceptibility to obesity. However, the underlying mechanisms are not completely understood. To investigate whether the gut microbiota affects hypothalamic and brainstem body fat-regulating circuits, we compared gene expression of food intake-regulating neuropeptides between germ-free and conventionally raised (CONV-R) mice. We found that CONV-R mice had decreased expression of the antiobesity neuropeptide glucagon-like peptide-1 (GLP-1) precursor proglucagon (Gcg) in the brainstem. Moreover, in both the hypothalamus and the brainstem, CONV-R

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Shen, Yi-Chen, Xiao Sun, Lei Li, Hu-Yunlong Zhang, Zhi-Li Huang, and Yi-Qun Wang. "Roles of Neuropeptides in Sleep–Wake Regulation." International Journal of Molecular Sciences 23, no. 9 (2022): 4599. http://dx.doi.org/10.3390/ijms23094599.

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Sleep and wakefulness are basic behavioral states that require coordination between several brain regions, and they involve multiple neurochemical systems, including neuropeptides. Neuropeptides are a group of peptides produced by neurons and neuroendocrine cells of the central nervous system. Like traditional neurotransmitters, neuropeptides can bind to specific surface receptors and subsequently regulate neuronal activities. For example, orexin is a crucial component for the maintenance of wakefulness and the suppression of rapid eye movement (REM) sleep. In addition to orexin, melanin-conce

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Semmens, Dean C., Olivier Mirabeau, Ismail Moghul, Mahesh R. Pancholi, Yannick Wurm, and Maurice R. Elphick. "Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution." Open Biology 6, no. 2 (2016): 150224. http://dx.doi.org/10.1098/rsob.150224.

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Neuropeptides are evolutionarily ancient mediators of neuronal signalling in nervous systems. With recent advances in genomics/transcriptomics, an increasingly wide range of species has become accessible for molecular analysis. The deuterostomian invertebrates are of particular interest in this regard because they occupy an ‘intermediate' position in animal phylogeny, bridging the gap between the well-studied model protostomian invertebrates (e.g. Drosophila melanogaster , Caenorhabditis elegans ) and the vertebrates. Here we have identified 40 neuropeptide precursors in the starfish Asterias

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Zestos, Alexander George, Nadiah Alyamni, and Jandro L. Abot. "Measurement of Neuropeptides and Amino Acids with Carbon-Fiber Multielectrode Array Enzyme-Modified Biosensors." ECS Meeting Abstracts MA2024-01, no. 49 (2024): 2673. http://dx.doi.org/10.1149/ma2024-01492673mtgabs.

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Carbon fiber microelectrodes (CFMEs) have been used to detect neurotransmitters and other biomolecules using fast-scan cyclic voltammetry (FSCV) for the past few decades. These assays typically measure small molecule neurotransmitters such as dopamine and serotonin. The carbon fiber is relatively small, biocompatible, and makes minimally invasive measurements at high spatial and temporal resolution. Carbon Fiber Multielectrode arrays have been utilized to measure multiple neurotransmitters in several brain regions simultaneously with multi-waveform application on each electrode. We have extend

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Wang, Ying, Juanjuan Kang, Ning Li, et al. "NeuroCS: A Tool to Predict Cleavage Sites of Neuropeptide Precursors." Protein & Peptide Letters 27, no. 4 (2020): 337–45. http://dx.doi.org/10.2174/0929866526666191112150636.

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Background: Neuropeptides are a class of bioactive peptides produced from neuropeptide precursors through a series of extremely complex processes, mediating neuronal regulations in many aspects. Accurate identification of cleavage sites of neuropeptide precursors is of great significance for the development of neuroscience and brain science. Objective: With the explosive growth of neuropeptide precursor data, it is pretty much needed to develop bioinformatics methods for predicting neuropeptide precursors’ cleavage sites quickly and efficiently. Method : We started with processing the neuropep

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Tu, Shisheng, Rui Xu, Mengen Wang, Xi Xie, Chenchang Bao, and Dongfa Zhu. "Identification and characterization of expression profiles of neuropeptides and their GPCRs in the swimming crab, Portunus trituberculatus." PeerJ 9 (September 15, 2021): e12179. http://dx.doi.org/10.7717/peerj.12179.

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Neuropeptides and their G protein-coupled receptors (GPCRs) regulate multiple physiological processes. Currently, little is known about the identity of native neuropeptides and their receptors in Portunus trituberculatus. This study employed RNA-sequencing and reverse transcription-polymerase chain reaction (RT-PCR) techniques to identify neuropeptides and their receptors that might be involved in regulation of reproductive processes of P. trituberculatus. In the central nervous system transcriptome data, 47 neuropeptide transcripts were identified. In further analyses, the tissue expression p

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Zhang, Lin, Fang Yang, Jinhong Cai, Chunmei Huang, Zhengkun Wang, and Wanlong Zhu. "The role of photoperiod on the expression of hypothalamic genes regulating appetite in Chevrier’s field mouse (Apodemus chevrieri)." Animal Biology 65, no. 1 (2015): 45–56. http://dx.doi.org/10.1163/15707563-00002460.

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The hypothalamus and leptin play a key role in the regulation of food intake. The present study investigated the effects of 4 weeks of short- or long-photoperiod on serum leptin levels and food intake in relation to mRNA expression levels of neuropeptide Y, agouti-related protein, pro-opiomelanocortin, and cocaine- and amphetamine-regulated transcript in the hypothalamus of Chevrier’s field mouse (Apodemus chevrieri). There was a significant difference in body fat mass, food intake and neuropeptide Y mRNA expression between the two groups, but serum leptin level, agouti-related protein, pro-op

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Bascal, Z. A., A. Montgomery, L. Holden-Dye, R. G. Williams, M. C. Thorndyke, and R. J. Walker. "NADPH diaphorase activity in peptidergic neurones of the parasitic nematode, Ascaris suum." Parasitology 112, no. 1 (1996): 125–34. http://dx.doi.org/10.1017/s0031182000065161.

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SUMMARYThe histochemical marker for nitric oxide synthase, NADPH diaphorase, is known to co-localize in mammalian neurones with various classical neurotransmitters and neuropeptides. The nervous system of the parasitic nematode Ascaris suum has previously been shown to contain both NADPH diaphorase activity and neuropeptide immunoreactivity. This study examined the possibility that NADPH diaphorase and neuropeptide immunoreactivity may co-exist in the same neurones. Two antisera were used, one raised to KYSALMFamide, a C-terminal synthetic analogue of SALMFamide 1 (GFNSALMFamide), and another

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Bowker, Robert M., Raymond H. Abhold, John P. Caron, Ioana M. Sonea, Kelly B. Vex, and Rebecca Kotyk. "Neuropeptidergic innervation of equine synovial joints." American Journal of Veterinary Research 54, no. 11 (1993): 1831–39. http://dx.doi.org/10.2460/ajvr.1993.54.11.1831.

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Summary Immunocytochemical analysis of equine synovial membranes revealed presence of several neuropeptides, including substance P (sp), neurokinin A, and neuropeptide Y, in nerves of the radiocarpal, middle carpal, and metacarpophalangeal (fetlock) joints. Within the subsynovium, these neuropeptides were located perivascularly, whereas in the fronds, only neuropeptide Y was restricted to the vessels of the synovial membrane. Only sp and neurokinin A were found in the intimal layer. The intimal layer of the metacarpophalangeal joint contained more sp-immunoreactive fibers than were observed in

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Feng, Jiao, Sinda Lepetre-Mouelhi, Anne Gautier, et al. "A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine." Science Advances 5, no. 2 (2019): eaau5148. http://dx.doi.org/10.1126/sciadv.aau5148.

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The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metabolized Leu-enkephalin (LENK) neuropeptide may become pharmacologically efficient owing to a simple conjugation with the lipid squalene (SQ). The corresponding LENK-SQ bioconjugates were synthesized using different chemical linkers in order to modulate the LENK release after their formulation into nanoparticles. This new SQ-based nanoformulation prevented rapid plasma degradation of

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Ertl, G., B. Bauer, H. H. Becker, and G. Rose. "Effects of neurotensin and neuropeptide Y on coronary circulation and myocardial function in dogs." American Journal of Physiology-Heart and Circulatory Physiology 264, no. 4 (1993): H1062—H1068. http://dx.doi.org/10.1152/ajpheart.1993.264.4.h1062.

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This study analyzed the effects of the neuropeptides, neurotensin, and human and porcine analogue, neuropeptide Y, in anesthetized open-chest dogs. The left anterior descending coronary artery was cannulated and perfused at constant pressure via a blood reservoir. Flow to the coronary cannula was measured by an electromagnetic flowmeter, and regional segment lengths were measured by sonomicrometer crystals. Neurotensin injected into the coronary cannula resulted in a dose-dependent increase of coronary flow; neuropeptide Y resulted in a decrease of coronary flow. Because these changes in flow

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Puri, Sudan, Brendan M. Kenyon, and Pedram Hamrah. "Immunomodulatory Role of Neuropeptides in the Cornea." Biomedicines 10, no. 8 (2022): 1985. http://dx.doi.org/10.3390/biomedicines10081985.

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The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their immunomodulatory functions in the

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